Samuel J. Danishefsky
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American chemist
Samuel J. Danishefsky's AcademicInfluence.com Rankings
Samuel J. Danishefskychemistry Degrees
Chemistry
#129
World Rank
#304
Historical Rank
#65
USA Rank
Organic Chemistry
#18
World Rank
#30
Historical Rank
#9
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Chemistry
Samuel J. Danishefsky's Degrees
- Bachelors Chemistry Yeshiva University
Why Is Samuel J. Danishefsky Influential?
(Suggest an Edit or Addition)According to Wikipedia, Samuel J. Danishefsky is an American chemist working as a professor at both Columbia University and the Memorial Sloan-Kettering Cancer Center in New York City. Birth and education Samuel J. Danishefsky was born in 1936 in the United States. He completed his B.S. from Yeshiva University in 1956. He earned his Ph.D. in chemistry from Harvard University in 1962 with Peter Yates, which partially overlapped with a National Institutes of Health postdoctoral fellowship in the laboratory of Gilbert Stork at Columbia University.
Samuel J. Danishefsky's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Papers
- The B-Alkyl Suzuki-Miyaura Cross-Coupling Reaction: Development, Mechanistic Study, and Applications in Natural Product Synthesis A list of abbreviations can be found at the end of the article. (2001) (584)
- Free-radical-based, specific desulfurization of cysteine: a powerful advance in the synthesis of polypeptides and glycopolypeptides. (2007) (570)
- Gelsemine: a thought-provoking target for total synthesis. (2003) (499)
- Glycals in Organic Synthesis: The Evolution of Comprehensive Strategies for the Assembly of Oligosaccharides and Glycoconjugates of Biological Consequence (1996) (481)
- Electrophilic cyclopropanes in organic synthesis (1979) (373)
- Useful diene for the Diels-Alder reaction (1974) (342)
- Total Synthesis of Spirotryprostatin A, Leading to the Discovery of Some Biologically Promising Analogues (1999) (336)
- On the direct epoxidation of glycals: application of a reiterative strategy for the synthesis of .beta.-linked oligosaccharides (1989) (325)
- Small molecule natural products in the discovery of therapeutic agents: the synthesis connection. (2006) (290)
- Carbohydrate vaccines in cancer: immunogenicity of a fully synthetic globo H hexasaccharide conjugate in man. (1999) (236)
- A strategy for the solid-phase synthesis of oligosaccharides. (1993) (213)
- Siloxy dienes in total synthesis (1981) (210)
- Immunization of metastatic breast cancer patients with a fully synthetic globo H conjugate: A phase I trial (2001) (190)
- Totally Synthetic Routes to the Higher Monosaccharides (1987) (189)
- Native chemical ligation at valine: a contribution to peptide and glycopeptide synthesis. (2008) (185)
- Toward fully synthetic glycoproteins by ultimately convergent routes: a solution to a long-standing problem. (2004) (179)
- Staged induction of HIV-1 glycan–dependent broadly neutralizing antibodies (2017) (176)
- Erythropoietin Derived by Chemical Synthesis (2013) (169)
- Synthetic and Immunological Studies on Clustered Modes of Mucin-Related Tn and TF O-Linked Antigens: The Preparation of a Glycopeptide-Based Vaccine for Clinical Trials against Prostate Cancer† (1998) (168)
- The Total Synthesis of Dynemicin A Leading to Development of a Fully Contained Bioreductively Activated Enediyne Prodrug (1996) (163)
- Mild Lewis acid catalysis: tris(6,6,7,7,8,8,8-heptafluoro-2,2-dimethyl-3,5-octanedionato)europium-mediated hetero-Diels-Alder reaction (1983) (163)
- Total Syntheses of Epothilones A and B (1997) (161)
- Fully synthetic carbohydrate-based vaccines in biochemically relapsed prostate cancer: clinical trial results with alpha-N-acetylgalactosamine-O-serine/threonine conjugate vaccine. (2003) (160)
- Total Synthesis of Epothilone A. (1996) (159)
- Lewis acid catalyzed cyclocondensations of functionalized dienes with aldehydes (1982) (151)
- Development of Globo-H cancer vaccine. (2015) (150)
- Interactivity of chiral catalysts and chiral auxiliaries in the cycloaddition of activated dienes with aldehydes: a synthesis of L-glucose (1986) (147)
- Synthetic analogues of migrastatin that inhibit mammary tumor metastasis in mice. (2005) (146)
- The migrastatin family: discovery of potent cell migration inhibitors by chemical synthesis. (2004) (139)
- Principles of mucin architecture: structural studies on synthetic glycopeptides bearing clustered mono-, di-, tri-, and hexasaccharide glycodomains. (2002) (138)
- Discovery of potent cell migration inhibitors through total synthesis: lessons from structure-activity studies of (+)-migrastatin. (2004) (138)
- Preparation and evaluation of unimolecular pentavalent and hexavalent antigenic constructs targeting prostate and breast cancer: a synthetic route to anticancer vaccine candidates. (2006) (136)
- Sulfonamidoglycosylation of glycals. A route to oligosaccharides with 2-aminohexose subunits (1990) (135)
- Total Synthesis of (–)‐Epothilone B: An Extension of the Suzuki Coupling Method and Insights into Structure–Activity Relationships of the Epothilones (1997) (134)
- Total Synthesis of Gypsetin, Deoxybrevianamide E, Brevianamide E, and Tryprostatin B: Novel Constructions of 2,3-Disubstituted Indoles (1999) (133)
- Total synthesis of (±)-pancratistatin (1989) (129)
- Building complex glycopeptides: Development of a cysteine-free native chemical ligation protocol. (2006) (128)
- New efficient synthesis of resorcinylic macrolides via ynolides: establishment of cycloproparadicicol as synthetically feasible preclinical anticancer agent based on Hsp90 as the target. (2004) (125)
- Total synthesis of TMC-95A and -B via a new reaction leading to Z-enamides. Some preliminary findings as to SAR. (2004) (124)
- On the scope, mechanism and stereochemistry of the Lewis acid catalyzed cyclocondensation of activated dienes with aldehydes: an application to the erythronolide problem (1985) (124)
- Vaccination of Patients with Small-Cell Lung Cancer with Synthetic Fucosyl GM-1 Conjugated to Keyhole Limpet Hemocyanin (2004) (119)
- Concise asymmetric syntheses of radicicol and monocillin I. (2001) (118)
- Reactions of silyl enol ethers and lactone enolates with dimethyl(methylene)ammonium iodide. The bis-.alpha.-methylenation of pre-vernolepin and pre-vernomenin (1976) (116)
- Immunization of ovarian cancer patients with a synthetic Lewisy‐protein conjugate vaccine: A phase 1 trial (2000) (116)
- A program for ligation at threonine sites: application to the controlled total synthesis of glycopeptides. (2010) (116)
- Stereoselective Total Syntheses of Amauromine and 5-N-Acetylardeemin. A Concise Route to the Family of "Reverse-Prenylated" Hexahydropyrroloindole Alkaloids (1994) (115)
- An oligosaccharide-based HIV-1 2G12 mimotope vaccine induces carbohydrate-specific antibodies that fail to neutralize HIV-1 virions (2008) (112)
- REMOTE EFFECTS IN MACROLIDE FORMATION THROUGH RING-FORMING OLEFIN METATHESIS : AN APPLICATION TO THE SYNTHESIS OF FULLY ACTIVE EPOTHILONE CONGENERS (1997) (112)
- A vision for vaccines built from fully synthetic tumor-associated antigens: from the laboratory to the clinic. (2013) (111)
- Experimental Diels-Alder reactivities of cycloalkenones and cyclic dienes explained through transition-state distortion energies. (2011) (111)
- Chiral induction in the cyclocondensation of aldehydes with siloxydienes (1984) (110)
- New chemistry with old functional groups: on the reaction of isonitriles with carboxylic acids--a route to various amide types. (2008) (109)
- Total synthesis of allosamidin : an application of the sulfonamidoglycosylation of glycals (1991) (108)
- Stereoselective total syntheses of the naturally occurring enantiomers of N-acetylneuraminic acid and 3-deoxy-D-manno-2-octulosonic acid. A new and stereospecific approach to sialo and 3-deoxy-D-manno-2-octulosonic acid conjugates (1988) (107)
- Diels-Alder reactions of trans-1-methoxy-3-trimethylsilyloxy-1,3-butadiene (1979) (107)
- The synthesis, discovery, and development of a highly promising class of microtubule stabilization agents: Curative effects of desoxyepothilones B and F against human tumor xenografts in nude mice (2001) (107)
- Pursuit of optimal carbohydrate-based anticancer vaccines: preparation of a multiantigenic unimolecular glycopeptide containing the Tn, MBr1, and Lewis(y) antigens. (2001) (107)
- Thomsen-Friedenreich (TF) antigen as a target for prostate cancer vaccine: clinical trial results with TF cluster (c)-KLH plus QS21 conjugate vaccine in patients with biochemically relapsed prostate cancer (2005) (106)
- An advance in proline ligation. (2011) (106)
- Antibody-Catalyzed Enantioselective Robinson Annulation (1997) (106)
- The total synthesis of avermectin A1a (1989) (106)
- Total synthesis of (±)-maoecrystal V. (2012) (106)
- First Total Synthesis of Staurosporine and ent-Staurosporine (1995) (105)
- The Total Synthesis of Eleutherobin (1999) (105)
- On the remarkable antitumor properties of fludelone: how we got there. (2005) (103)
- The total synthesis of dl-vernolepin and dl-vernomenin (1977) (102)
- Staurosporine and ent-Staurosporine: The First Total Syntheses, Prospects for a Regioselective Approach, and Activity Profiles1 (1996) (101)
- Toward optimized carbohydrate-based anticancer vaccines: Epitope clustering, carrier structure, and adjuvant all influence antibody responses to Lewisy conjugates in mice (2001) (101)
- The total synthesis of zincophorin (1987) (101)
- Chelation-controlled facially selective cyclocondensation reactions of chiral alkoxy aldehydes: syntheses of a mouse androgen and of a carbon-linked disaccharide (1985) (100)
- Insights into the finer issues of native chemical ligation: an approach to cascade ligations. (2010) (100)
- In pursuit of carbohydrate-based HIV vaccines, part 2: The total synthesis of high-mannose-type gp120 fragments--evaluation of strategies directed to maximal convergence. (2004) (99)
- A strategy for a convergent synthesis of N-linked glycopeptides on a solid support. (1995) (98)
- Major Simplifications in Oligosaccharide Syntheses Arising from a Solid-Phase Based Method: An Application to the Synthesis of the Lewis b Antigen (1995) (98)
- Structure–Activity Relationship of the Epothilones and the First In Vivo Comparison with Paclitaxel† (1997) (98)
- Synthesis of two useful, enantiomerically pure derivatives of (S)-4-hydroxy-2-cyclohexenone (1989) (96)
- Fully synthetic carbohydrate HIV antigens designed on the logic of the 2G12 antibody. (2007) (94)
- Comparison of antigen constructs and carrier molecules for augmenting the immunogenicity of the monosaccharide epithelial cancer antigen Tn (2005) (94)
- Concise total syntheses of dl-camptothecin and related anticancer drugs (1993) (92)
- Total synthesis and determination of the absolute configuration of frondosin B. (2001) (91)
- Complex Target-Oriented Synthesis in the Drug Discovery Process: A Case History in the dEpoB Series (1999) (90)
- Advances in proline ligation. (2012) (90)
- A fascinating journey into history: exploration of the world of isonitriles en route to complex amides. (2012) (90)
- Origins of stereoselectivity in the trans Diels-Alder paradigm. (2010) (90)
- On the power of chemical synthesis: Immunological evaluation of models for multiantigenic carbohydrate-based cancer vaccines (2002) (90)
- In pursuit of carbohydrate-based HIV vaccines, part 1: The total synthesis of hybrid-type gp120 fragments. (2004) (90)
- On the interactivity of chiral auxiliaries with chiral catalysts in the hetero Diels-Alder reaction: a new route to L-glycolipids (1983) (89)
- On the lewis acid catalyzed cyclocondensation of imines with a siloxydiene (1983) (88)
- Prospects for total synthesis: a vision for a totally synthetic vaccine targeting epithelial tumors. (2004) (88)
- A stereoselective synthesis of indole-.beta.-N-glycosides: an application to the synthesis of rebeccamycin (1993) (88)
- Toward fully synthetic carbohydrate-based HIV antigen design: on the critical role of bivalency. (2004) (88)
- TOTAL SYNTHESIS OF A HUMAN BREAST TUMOR ASSOCIATED ANTIGEN (1995) (86)
- Optically specific synthesis of estrone and 19-norsteroids from 2,6-lutidine. (1976) (86)
- On the addition of allyltrimethylsilane to glycal acetates (1982) (86)
- Total Synthesis of (±)-Garsubellin A (2005) (85)
- A Broadly Applicable Method for the Efficient Synthesis of α-O-Linked Glycopeptides and Clustered Sialic Acid Residues (1999) (85)
- Thio FCMA intermediates as strong acyl donors: a general solution to the formation of complex amide bonds. (2009) (84)
- The total synthesis of proteasome inhibitors TMC-95A and TMC-95B: discovery of a new method to generate cis-propenyl amides. (2002) (84)
- A concise and stereoselective route to the predominant stereochemical pattern of the tetrahydropyranoid antibiotics: an application to indanomycin (1987) (83)
- From the Laboratory to the Clinic: A Retrospective on Fully Synthetic Carbohydrate-Based Anticancer Vaccines (2000) (83)
- Calicheamicin-DNA complexes: warhead alignment and saccharide recognition of the minor groove. (1995) (83)
- Applications of total synthesis to problems in neurodegeneration: Fascinating chemistry along the way. (2006) (82)
- Discovery of (E)-9,10-dehydroepothilones through chemical synthesis: on the emergence of 26-trifluoro-(E)-9,10-dehydro-12,13-desoxyepothilone B as a promising anticancer drug candidate. (2004) (81)
- A potentially valuable advance in the synthesis of carbohydrate-based anticancer vaccines through extended cycloaddition chemistry. (2006) (81)
- Discovery through total synthesis: a retrospective on the himastatin problem. (2001) (81)
- The total synthesis of (+/-)-11-O-debenzoyltashironin. (2006) (80)
- Total synthesis of salinosporamide A. (2005) (80)
- Highly activated cyclopropane for homoconjugate reactions (1975) (79)
- The total synthesis of (+)-migrastatin. (2003) (78)
- A Fully Synthetic Globo H Carbohydrate Vaccine Induces a Focused Humoral Response in Prostate Cancer Patients: A Proof of Principle. (1999) (78)
- The total synthesis of the aglycon of avermectin A1a (1987) (78)
- Toward fully synthetic homogeneous beta-human follicle-stimulating hormone (beta-hFSH) with a biantennary N-linked dodecasaccharide. synthesis of beta-hFSH with chitobiose units at the natural linkage sites. (2009) (78)
- Total synthesis of rapamycin via a novel titanium-mediated aldol macrocyclization reaction (1993) (78)
- Total synthesis of cyclosporine: access to N-methylated peptides via isonitrile coupling reactions. (2010) (78)
- From synthesis to biologics: preclinical data on a chemistry derived anticancer vaccine. (2009) (78)
- Solid-Phase Synthesis of Oligosaccharides and Glycoconjugates by the Glycal Assembly Method: A Five Year Retrospective (1998) (77)
- A Rapid Total Synthesis of Spirotryprostatin B: Proof of Its Relative and Absolute Stereochemistry (2000) (77)
- Highly concise routes to epothilones: the total synthesis and evaluation of epothilone 490. (2002) (77)
- A bivalent conjugate vaccine in the treatment of biochemically relapsed prostate cancer: a study of glycosylated MUC-2-KLH and Globo H-KLH conjugate vaccines given with the new semi-synthetic saponin immunological adjuvant GPI-0100 OR QS-21. (2005) (77)
- Total Synthesis of Himastatin: Confirmation of the Revised Stereostructure. (1998) (77)
- Pattern recognition in retrosynthetic analysis: snapshots in total synthesis. (2007) (76)
- Derivatives of 1-methoxy-3-trimethylsilyloxy-1,3-butadiene for Diels-Alder reactions (1979) (75)
- Total syntheses of ML-236A and compactin by combining the lactonic (silyl) enolate rearrangement and aldehyde-diene cyclocondensation technologies (1989) (73)
- The carbohydrate domain of calicheamicin gamma I1 determines its sequence specificity for DNA cleavage. (1991) (73)
- On the reach of chemical synthesis: creation of a mini-pipeline from an academic laboratory. (2010) (73)
- The Total Synthesis of Spirotryprostatin A. (1998) (73)
- Differentiation of nonconventional "carbanions"-the total synthesis of nemorosone and clusianone. (2007) (73)
- Total synthesis of calicheamicinone: new arrangements for actuation of the reductive cycloaromatization of aglycon congeners (1991) (72)
- Cram rule selectivity in the Lewis acid catalyzed cyclocondensation of chiral aldehydes. A convenient route to chiral systems of biological interest (1982) (72)
- Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide (2017) (72)
- Displacement reactions of a 1,2-anhydro-alpha-D-hexopyranose: installation of useful functionality at the anomeric carbon. (1990) (72)
- On the communication of chirality from furanose and pyranose rings to monosaccharide side chains: anomalous results in the glucose series (1986) (71)
- Novel stereospecific silyl group transfer reactions: practical routes to the prostaglandins (1989) (70)
- Development of efficient methods for accomplishing cysteine-free peptide and glycopeptide coupling. (2007) (70)
- Immunization of Mice with a Fully Synthetic Globo H Antigen Results in Antibodies against Human Cancer Cells: A Combined Chemical—Immunological Approach to the Fashioning of an Anticancer Vaccine (1997) (70)
- A novel α,β-unsaturated nitrone-aryne [3+2] cycloaddition and its application in the synthesis of the cortistatin core. (2008) (70)
- Convergent total synthesis of a tumour-associated mucin motif (1997) (70)
- Recognition of synthetic glycopeptides by HIV-1 broadly neutralizing antibodies and their unmutated ancestors (2013) (70)
- Conformational influences of glycosylation of a peptide: a possible model for the effect of glycosylation on the rate of protein folding. (1996) (70)
- Observations in the Chemistry and Biology of Cyclic Enediyne Antibiotics: Total Syntheses of Calicheamicin γ1I and Dynemicin A (1996) (70)
- The total synthesis of indolizomycin (1993) (69)
- Application of the Ibuka-Yamamoto reaction to a problem in stereochemical communication: a strategy for the stereospecific synthesis and stabilization of the triene substructure of rapamycin through sulfone substitution (1991) (69)
- Studies toward a Synthesis of Epothilone A: Stereocontrolled Assembly of the Acyl Region and Models for Macrocyclization. (1996) (69)
- Total Synthesis and Proof of Structure of a Human Breast Tumor (Globo-H) Antigen (1996) (69)
- Total synthesis of (-)-scabronine G, an inducer of neurotrophic factor production. (2005) (68)
- At last: erythropoietin as a single glycoform. (2012) (67)
- Total synthesis of UCS1025A. (2006) (67)
- On the potential of natural products in the discovery of pharma leads: a case for reassessment. (2010) (67)
- Total Synthesis of (±)‐Dynemicin A (1995) (67)
- Stereospecific formal total synthesis of ecteinascidin 743. (2006) (67)
- The Total Synthesis of Eleutherobin: A Surprise Ending. (1998) (67)
- Chemical synthesis of normal and transformed PSA glycopeptides. (2004) (66)
- Complex target-oriented total synthesis in the drug discovery process: the discovery of a highly promising family of second generation epothilones. (2003) (66)
- A stereospecific route to 2-deoxy-β-glycosides (1991) (65)
- Total synthesis of (.+-.)-3-deoxy-D-manno-2-octulopyranosate (1985) (65)
- Stereospecific synthesis of aryl .beta.-glucosides: an application to the synthesis of a prototype corresponding to the aryloxy carbohydrate domain of vancomycin (1992) (65)
- The total synthesis of chilenine: Novel constructions of cyclic enamides (1989) (64)
- COUPLING OF GLYCAL DERIVED THIOETHYL GLYCOSYL DONORS WITH GLYCAL ACCEPTORS. AN ADVANCE IN THE SCOPE OF THE GLYCAL ASSEMBLY (1997) (64)
- Total synthesis of cribrostatin IV: fine-tuning the character of an amide bond by remote control. (2005) (64)
- Total Syntheses of (+)- and (−)-Peribysin E (2008) (63)
- Explorations in organic chemistry leading to the total synthesis of (+/-)-gelsemine. (2002) (63)
- Total synthesis of the novel benzopentathiepin varacinium trifluoroacetate: the viability of "varacin-free base" (1993) (63)
- The use of trans-methyl .beta.-nitroacrylate in Diels-Alder reactions (1978) (63)
- Total synthesis as a resource in the discovery of potentially valuable antitumor agents: cycloproparadicicol. (2003) (63)
- Transannular macrocyclization via intramolecular B-alkyl Suzuki reaction. (2000) (63)
- Synthetic carbohydrate-based anticancer vaccines: the Memorial Sloan-Kettering experience (2009) (63)
- Total synthesis of (+/-)-aplykurodinone-1: traceless stereochemical guidance. (2010) (62)
- Application of Glycals to the Synthesis of Oligosaccharides: Convergent Total Syntheses of the Lewis X Trisaccharide Sialyl Lewis X Antigenic Determinant and Higher Congeners (1995) (62)
- Diverted total synthesis leads to the generation of promising cell-migration inhibitors for treatment of tumor metastasis: in vivo and mechanistic studies on the migrastatin core ether analog. (2010) (62)
- A highly convergent total synthetic route to glycopeptides carrying a high-mannose core pentasaccharide domain N-linked to a natural peptide motif (1997) (62)
- Biologics through chemistry: total synthesis of a proposed dual-acting vaccine targeting ovarian cancer by orchestration of oligosaccharide and polypeptide domains. (2009) (62)
- Stereochemical consequences of the Lewis acid catalyzed cyclocondensation of oxygenated dienes with aldehydes. A rapid and stereoselective entry to various natural products derived from propionate (1982) (62)
- Stereospecific Vorbrueggen-like reactions of 1,2-anhydro sugars. An alternative route to the synthesis of nucleosides (1990) (62)
- Total synthesis of aigialomycin D. (2004) (62)
- Synthetic carbohydrate-based antitumor vaccines: challenges and opportunities (2005) (61)
- Promising general solution to the problem of ligating peptides and glycopeptides. (2010) (61)
- A concise total synthesis of dysidiolide through application of a dioxolenium-mediated Diels-Alder reaction (1998) (61)
- A formal synthesis of FK-506. Exploration of some alternatives to macrolactamization (1990) (61)
- Claisen rearrangements of lactonic (silyl) enolates: a new route to functionalized cycloalkenes (1980) (61)
- Total synthesis of vineomycinone B2 methyl ester (1985) (60)
- Total synthesis of enantiopure phalarine via a stereospecific Pictet-Spengler reaction: traceless transfer of chirality from L-tryptophan. (2010) (60)
- Fully synthetic stereoselective routes to the differentially protected subunits of the tunicamycins (1989) (60)
- On the conversion of biologically interesting amines to hydroxylamines (1990) (59)
- Vaccine Elicitation of High Mannose-Dependent Neutralizing Antibodies against the V3-Glycan Broadly Neutralizing Epitope in Nonhuman Primates. (2017) (59)
- An advance in the chemical synthesis of homogeneous N-linked glycopolypeptides by convergent aspartylation. (2012) (59)
- A new approach to the synthesis of hexoses: an entry to (.+-.)-fucose and (.+-.)-daunosamine (1985) (59)
- Specificity, inhibition, and synthetic utility of a recombinant human α-1,3-fucosyltransferase (1992) (59)
- A totally synthetic route to lincosamine: some observations on the diastereofacial selectivity of electrophilic reactions on the double bonds of various 5-(1-alkenyl)arabinopyranosides (1985) (59)
- Total synthesis of (+/-)-jiadifenin and studies directed to understanding its SAR: probing mechanistic and stereochemical issues in palladium-mediated allylation of enolate-like structures. (2006) (59)
- Total synthesis of the Fusarium toxin Equisetin : Proof of the stereochemical relationship of the tetramate and terpenoid sectors (1989) (58)
- Total synthesis of (+-)-camptothecine (1971) (58)
- Oxo-ester mediated native chemical ligation: concept and applications. (2008) (58)
- On the rearrangement of an azaspiroindolenine to a precursor to phalarine: mechanistic insights. (2007) (58)
- A preclinical study comparing approaches for augmenting the immunogenicity of a heptavalent KLH-conjugate vaccine against epithelial cancers (2003) (57)
- Totalsynthesen höherer Monosaccharide (1987) (57)
- Application of the Glycal Assembly Method to the Concise Synthesis of Neoglycoconjugates of Ley and Leb Blood Group Determinants and of H-Type I and H-Type II Oligosaccharides (1995) (57)
- Toward homogeneous erythropoietin: non-NCL-based chemical synthesis of the Gln78-Arg166 glycopeptide domain. (2009) (57)
- Total Synthesis of (.+-.)-FR-900482 (1995) (57)
- Chemical synthesis of highly congested gp120 V1V2 N-glycopeptide antigens for potential HIV-1-directed vaccines. (2013) (57)
- Exploration of Modalities in Building α-O-Linked Systems through Glycal Assembly: A Total Synthesis of the Mucin-Related F1α Antigen (1998) (57)
- Enantioselective synthesis of the oxadecalin core of phomactin A via a highly stereoselective Diels-Alder reaction. (2001) (56)
- The total synthesis of (+/-)-rishirilide B. (2001) (56)
- Total syntheses of KS-501, KS-502, and their enantiomers (1992) (56)
- Isoxazole annelation reaction. Method for the construction of cyclohexenone rings in polycyclic systems (1967) (56)
- Route from Glycals to Mannose .beta.-Glycosides (1994) (55)
- Straightforward synthesis of panaxytriol: an active component of Red Ginseng. (2003) (55)
- Total synthesis of guanacastepene a: a route to enantiomeric control. (2005) (55)
- A Remarkable Cross Coupling Reaction to Construct the Enediyne Linkage Relevant to Dynemicin A: Synthesis of the Deprotected ABC System (1994) (55)
- Insights into long-range structural effects on the stereochemistry of aldol condensations: a practical total synthesis of desoxyepothilone F. (2001) (55)
- Therapeutic effect against human xenograft tumors in nude mice by the third generation microtubule stabilizing epothilones (2008) (55)
- Design and Synthesis of Ley-Bearing Glycopeptides that Mimic Cell Surface Ley Mucin Glycoprotein Architecture (2000) (55)
- Total synthesis of calicheamicinone: a solution to the problem of the elusive urethane (1990) (55)
- An approach to the synthesis of bactobolin and the total synthesis of N-acetylactinobolamine: some remarkably stable hemiacetals (1987) (55)
- Synthesis of the Core Trisaccharide of Esperamicin: Corroboration of the Proposed Structure for Its Rearrangement Product and Stabilization of the Core Trisaccharide Domain. (1991) (54)
- Studies in the Total Synthesis of Himastatin: A Revision of the Stereochemical Assignment. (1998) (54)
- A stereospecific route to aziridinomitosanes: the synthesis of novel mitomycin congeners (1985) (54)
- Design and total synthesis of a superior family of epothilone analogues, which eliminate xenograft tumors to a nonrelapsable state. (2003) (54)
- Application of the logic of cysteine-free native chemical ligation to the synthesis of Human Parathyroid Hormone (hPTH) (2011) (53)
- A stereoselective route from glycals to asparagine-linked N-protected glycopeptides (1992) (53)
- Azaglycosylation of complex stannyl alkoxides with glycal-derived iodo sulfonamides: a straightforward synthesis of sialyl-Lewis X antigen and other oligosaccharide domains (1992) (53)
- New Chemical Synthesis of the Promising Cancer Chemotherapeutic Agent 12,13-Desoxyepothilone B: Discovery of a Surprising Long-Range Effect on the Diastereoselectivity of an Aldol Condensation (1999) (53)
- A stereoselective route to guanacastepene A through a surprising epoxidation. (2002) (53)
- Tetrahydropyridones via intramolecular ureidomercuration (1983) (53)
- Total synthesis of the potential anticancer vaccine KH-1 adenocarcinoma antigen (1997) (53)
- Studies related to the relative thermodynamic stability of C-terminal peptidyl esters of O-hydroxy thiophenol: emergence of a doable strategy for non-cysteine ligation applicable to the chemical synthesis of glycopeptides. (2006) (53)
- Total synthesis as a resource in drug discovery: the first in vivo evaluation of panaxytriol and its derivatives. (2005) (52)
- Toward fully synthetic N-linked glycoproteins. (2003) (52)
- Synthetic studies toward aflavinine: a synthesis of 3-demethylaflavinine via a [2 + 2 + 2] annulation (1985) (52)
- Comparison of antibody titers after immunization with monovalent or tetravalent KLH conjugate vaccines. (2002) (52)
- Addressing mechanistic issues in the coupling of isonitriles and carboxylic acids: potential routes to peptidic constructs. (2008) (51)
- Lanthanide catalysis of cycloadditions of heterodienes with enol ethers (1984) (51)
- A route to glycals in the allal and gulal series: synthesis of the thiosugar of esperamicin A1 (1990) (51)
- A striking example of the interfacing of glycal chemistry with enzymatically mediated sialylation: a concise synthesis of ganglioside GM3 (1993) (51)
- Total Synthesis of Tryprostatin B: Generation of a Nucleophilic Prenylating Species from a Prenylstannane (1996) (51)
- Cyclizations of mercury and palladium substituted acyrylanilides (1983) (51)
- Synthesis of a cyanobacterial sulfolipid: confirmation of its structure, stereochemistry and anti-HIV-1 activity (1992) (51)
- A Fully Synthetic Route to the Neurotrophic Illicinones: Syntheses of Tricycloillicinone and Bicycloillicinone Aldehyde (2000) (51)
- Total synthesis of (.+-.)-3-demethoxyerythratidinone: demonstration of a radical cyclization route to a site specific enol derivative (1987) (50)
- A Convergent Total Synthesis of Calicheamicin γ (1994) (50)
- The Total Synthesis of Allosamidin. Expansions of the Methodology of Azaglycosylation Pursuant to the Total Synthesis of Allosamidin. A Surprising Enantiotopic Sense for a Lipase-Induced Deacetylation (1996) (50)
- The epothilones, eleutherobins, and related types of molecules. (2001) (50)
- The total synthesis of dl-indolizomycin (1990) (50)
- A second generation synthesis of the MBr1 (globo-H) breast tumor antigen: new application of the n-pentenyl glycoside method for achieving complex carbohydrate protein linkages. (2000) (50)
- NEW ROUTES TO FUNCTIONALIZED BENZAZEPINE SUBSTRUCTURES : A NOVEL TRANSFORMATION OF AN ALPHA -DIKETONE THIOAMIDE INDUCED BY TRIMETHYL PHOSPHITE (1990) (50)
- Interaction of the aryl tetrasaccharide domain of calicheamicin .gamma.1I with DNA: influence on aglycon and methidiumpropyl-EDTA.cntdot.iron(II)-mediated DNA cleavage (1992) (50)
- Immunogenicity of synthetic conjugates of Lewisy oligosaccharide with proteins in mice: towards the design of anticancer vaccines (1998) (49)
- Reductive cyclization of mercurial enones (1982) (49)
- Concise route to the calichemicin-esperamicin series: the crystal structure of an aglycone prototype (1988) (49)
- A Novel Aldol Condensation with 2-Methyl-4-pentenal and Its Application to an Improved Total Synthesis of Epothilone B. (1998) (49)
- Stereospecific total synthesis of dl-pentalenolactone (1978) (49)
- Studies Related to the Carbohydrate Sectors of Esperamicin and Calicheamicin: Definition of the Stability Limits of the Esperamicin Domain and Fashioning of a Glycosyl Donor from the Calicheamicin Domain (1995) (48)
- Communications- Preparation of α-Diazo Ketones (1961) (48)
- On the two-component microwave-mediated reaction of isonitriles with carboxylic acids: regarding alleged formimidate carboxylate mixed anhydrides. (2008) (48)
- Chemical Explorations Driven by an Enchantment With Mitomycinoids - A Twenty Year Account (1995) (48)
- A fully synthetic route to tunicaminyluracil (1985) (48)
- Total synthesis of dl-quadrone (1980) (48)
- Total synthesis of dl-coriolin (1980) (48)
- Total synthesis of the 2,6-sialylated immunoglobulin G glycopeptide fragment in homogeneous form. (2009) (48)
- Studies directed to the total synthesis of ET 743 and analogues thereof: an expeditious route to the ABFGH subunit. (2002) (47)
- Effects of temperature and concentration in some ring closing metathesis reactions (2003) (47)
- Application of ring-closing metathesis reactions in the synthesis of epothilones. (2004) (47)
- A total synthesis of xestodecalactone a and proof of its absolute stereochemistry: interesting observations on dienophilic control with 1,3-disubstituted nonequivalent allenes. (2006) (47)
- Preparation of activated cyclopropanes by phase transfer alkylation (1975) (47)
- A CONVERGENT ROUTE FOR THE TOTAL SYNTHESIS OF THE ELEUTHESIDES (1998) (47)
- On the diastereofacial selectivity of Lewis acid-catalyzed carbon-carbon bond forming reactions of conjugated cyclic enones bearing electron-withdrawing substituents at the .gamma.-position (1991) (47)
- Synthesis of pluraflavin A "aglycone". (2008) (47)
- First Synthesis of a Digitalis Saponin. Demonstration of the Scope and Limitations of a Convergent Scheme for Branched Oligosaccharide Synthesis by the Logic of Glycal Assembly (1995) (46)
- Stereospecific total syntheses of dl-coriolin and dl-coriolin B (1981) (46)
- Total synthesis of paecilomycine A. (2007) (46)
- Free‐Radical‐Based, Specific Desulfurization of Cysteine: A Powerful Advance in the Synthesis of Polypeptides and Glycopolypeptides. (2008) (45)
- The total synthesis of octosyl acid A: a new departure in organostannylene chemistry. (1986) (45)
- Toward homogeneous erythropoietin: chemical synthesis of the Ala1-Gly28 glycopeptide domain by "alanine" ligation. (2009) (45)
- Studies relating to the synthesis of the immunosuppressive agent FK-506: coupling of fragments via a stereoselective trisubstituted olefin forming reaction sequence (1989) (45)
- New Applications of the n-Pentenyl Glycoside Method in the Synthesis and Immunoconjugation of Fucosyl GM1: A Highly Tumor-Specific Antigen Associated with Small Cell Lung Carcinoma (1999) (45)
- Monitoring the Progress of Solid‐Phase Oligosaccharide Synthesis by High‐Resolution Magic Angle Spinning NMR: Observations of Enhanced Selectivity for β‐Glycoside Formation from α‐1,2‐Anhydrosugar Donors in Solid‐Phase Couplings (1997) (45)
- Emergence of potent inhibitors of metastasis in lung cancer via syntheses based on migrastatin (2011) (44)
- Cyclobutenone as a highly reactive dienophile: expanding upon Diels-Alder paradigms. (2010) (44)
- Encouraging progress in the ω-aspartylation of complex oligosaccharides as a general route to β-N-linked glycopolypeptides. (2011) (44)
- Probing cell-surface architecture through synthesis: an NMR-determined structural motif for tumor-associated mucins. (1999) (44)
- The first synthesis of a fully functionalized core structure of staurosporine : sequential indolyl glycosidation by endo and exo glycals (1993) (43)
- Toward homogeneous erythropoietin: fine tuning of the C-terminal acyl donor in the chemical synthesis of the Cys29-Gly77 glycopeptide domain. (2009) (43)
- Development of a fully synthetic stereoselective route to 6-deoxyerythronolide B by reiterative applications of the Lewis acid catalyzed diene aldehyde cyclocondensation reaction: a remarkable instance of diastereofacial selectivity (1990) (43)
- Expeditious synthesis of the polypropionate sector of rifamycin S by reiterative Diene-Aldehyde cyclocondensation reactions (1987) (43)
- Synthesis of 18-Noranhydrocamptothecin Analogs Which Retain Topoisomerase I Inhibitory Function (1994) (43)
- Studies toward the total synthesis of phalarine: a survey of some biomimetic possibilities (2006) (43)
- Recent Departures in the Synthesis of Peptides and Glycopeptides. (2009) (43)
- The total synthesis of avermectin A1a. New protocols for the synthesis of novel 2-deoxypyranose systems and their axial glycosides (1987) (42)
- Polyclonal antibodies from patients immunized with a globo H-keyhole limpet hemocyanin vaccine: isolation, quantification, and characterization of immune responses by using totally synthetic immobilized tumor antigens. (2000) (42)
- A route to artificial glycoconjugates and oligosaccharides via enzymatically resolved glycals: Dramatic effects of the handedness of the sugar domain upon the properties of an anthracycline drug (1992) (42)
- Synthesis of the Functionalized Macrocyclic Core of Proteasome Inhibitors TMC‐95A and B (2001) (42)
- Synthesis of an enantiomerically pure intermediate containing the CD substructure of taxol (1993) (42)
- The winding pathway to erythropoietin along the chemistry-biology frontier: a success at last. (2013) (42)
- The coupling of isonitriles and carboxylic acids occurring by sequential concerted rearrangement mechanisms. (2008) (42)
- Bis annelations via 6-methyl-2-vinylpyridine. An efficient synthesis of dl-D-homoestrone. (1975) (41)
- Remarkable regioselectivity in the chemical glycosylation of glycal acceptors: a concise solution to the synthesis of sialyl-Lewis X glycal. (1992) (41)
- Rational development of a strategy for modifying the aggregatibility of proteins (2011) (41)
- Strategy in Oligosaccharide Synthesis: An Application to a Concise Total Synthesis of the KH-1(adenocarcinoma) Antigen (1998) (41)
- A synthetic pathway to either enantiomer of merrilactone A. (2005) (41)
- Experiments Directed toward a Total Synthesis of Dynemicin A: A Solution to the Stereochemical Problem (1994) (41)
- Application of hitherto unexplored macrocyclization strategies in the epothilone series: novel epothilone analogs by total synthesis. (2002) (41)
- An Interactive Strategy for the Assembly of Complex, Branched Oligosaccharide Domains on a Solid Support: A Concise Synthesis of the Lewisb Domain in Bioconjugatable Form (1994) (41)
- Total synthesis of (+/-)-jiadifenin, a non-peptidyl neurotrophic modulator. (2004) (41)
- Total synthesis of the α-subunit of human glycoprotein hormones: toward fully synthetic homogeneous human follicle-stimulating hormone. (2012) (41)
- On the interactivity of complex synthesis and tumor pharmacology in the drug discovery process: total synthesis and comparative in vivo evaluations of the 15-aza epothilones. (2001) (41)
- A four-step synthesis of the hydroazulene core of guanacastepene. (2001) (41)
- Synthesis of the fucosylated biantennary N-glycan of erythropoietin (2006) (41)
- Total synthesis of (.+-.)-heptelidic acid (1988) (40)
- A concise synthesis of the cortistatin core. (2008) (40)
- On the characterization of intermediates in the mitomycin activation cascade: a practical synthesis of an aziridinomitosene (1986) (40)
- Total Synthesis of (.+-.)-Myrocin C (1994) (40)
- RITTER-LIKE REACTIONS OF 1,2-ANHYDROPYRANOSE DERIVATIVES (1991) (40)
- Synthesis of the functionalized tricyclic core of lactonamycin by oxidative dearomatization. (2000) (40)
- Characterization of 2-siloxyoxiranes formed by epoxidation of silyl enol ethers with dimethyldioxirane (1989) (40)
- Specific inhibition of formation of transcription complexes by a calicheamicin oligosaccharide: a paradigm for the development of transcriptional antagonists. (1994) (40)
- Total Synthesis of Gypsetin (1995) (40)
- Toward Fully Synthetic Homogeneous Glycoproteins: A High Mannose Core Containing Glycopeptide Carrying Full H‐Type 2 Human Blood Group Specificity (2001) (39)
- Building biologics by chemical synthesis: practical preparation of di- and triantennary N-linked glycoconjugates. (2013) (39)
- Toward fully synthetic, homogeneous glycoproteins: advances in chemical ligation. (2010) (39)
- A novel Heck arylation reaction: rapid access to congeners of FR 900482 (1993) (39)
- Synthetic studies toward Maoecrystal V (2009) (39)
- Studies in the Total Synthesis of Heliquinomycinone: Proof of Concept and Assembly of a Fully Mature Spirocyclization Precursor (2001) (39)
- Studies toward a Synthesis of Epothilone A: Use of Hydropyran Templates for the Management of Acyclic Stereochemical Relationships. (1996) (39)
- Application of substituent-controlled oxidative coupling of glycals in a synthesis and structural corroboration of ciclamycin 0: new possibilities for the construction of hybrid anthracyclines (1990) (39)
- A concise total synthesis of (±)-ipalbidine by application of the aldimine-diene cyclocondensation reaction (1986) (39)
- Solving the convergence problem in the synthesis of triantennary N-glycan relevant to prostate-specific membrane antigen (PSMA). (2012) (39)
- The aza-Robinson annulation: an application to the synthesis of iso-A58365A (1989) (39)
- A Remarkable Glycosidation Reaction: The Total Synthesis of Calicheamicin .gamma.1I (1995) (39)
- Kinetically controlled total syntheses of dl-trachelanthamidine and dl-isoretronecanol (1977) (39)
- A Powerful o-Quinone Dimethide Strategy for Intermolecular Diels−Alder Cycloadditions (2000) (38)
- Studies towards the total synthesis of halichlorine: asymmetric synthesis of the spiroquinolizidine subunit (1999) (38)
- Probing the frontiers of glycoprotein synthesis: the fully elaborated β-subunit of the human follicle-stimulating hormone. (2012) (38)
- A straightforward route to functionalized intermediates containing the CD substructure of taxol. (1992) (38)
- Total synthesis of quinocarcinol methyl ester (1985) (38)
- Synthetic studies toward rapamycin : a solution to a problem in chirality merger through use of the Ireland reaction (1991) (38)
- Stereoselective syntheses of FK-506 subunits by the Rhodium(I)-catalyzed hydrogenation of dienes. The synthesis and coupling of a C10-C19 fragment (1989) (38)
- Stereochemical variations in the cyclocondensation of aldehydes with siloxydienes. An application to the erythronolide series (1982) (38)
- A concise route to benzofused macrolactones via ynolides: cycloproparadicicol. (2003) (38)
- The Total Synthesis of Heliquinomycinone (2001) (38)
- A fully synthetic route to the papulacandins. Stereo-specific spiroacetalization of a C-1-arylated methyl glycoside. (1987) (38)
- Use of .beta.-phenylsulfinyl-.alpha.,.beta.-unsaturated carbonyl dienophiles in Diels-Alder reactions (1979) (38)
- A Concise Total Synthesis of (±)‐Mamanuthaquinone by Using an exo‐Diels–Alder Reaction (1994) (38)
- Intramolecular cycloaddition reactions of dienyl nitroso compounds: application to the synthesis of mitomycin K (1993) (38)
- Total syntheses of [17]- and [18]dehydrodesoxyepothilones B via a concise ring-closing metathesis-based strategy: correlation of ring size with biological activity in the epothilone series. (2002) (38)
- Total synthesis of dl-pentalenolactone (1979) (38)
- Synthesis of the functionalized tricyclic skeleton of guanacastepene A: a tandem epoxide-opening beta-elimination/knoevenagel cyclization. (2002) (38)
- Regioselective mannich reactions via trimethylsilyl enol ethers (1980) (37)
- Preparation and reactions of N-thioformyl peptides from amino thioacids and isonitriles. (2009) (37)
- A simple synthesis of L-.gamma.-carboxyglutamate and derivatives thereof (1979) (37)
- A concise total synthesis of defucogilvocarcin V by application of the meyers biaryl strategy: ortho- and para-selective functionalizations of the A ring (1988) (37)
- Remarkable stereoselectivity in the alkylation of a hydroazulenone: progress towards the total synthesis of guanacastepene (2001) (37)
- Stereoselective syntheses and evaluation of compounds in the 8-desmethylepothilone a series: Some surprising observations regarding their chemical and biological properties (1997) (37)
- Solid Support Oligosaccharide Synthesis: Construction of β-Linked Oligosaccharides by Coupling of Glycal Derived Thioethyl Glycosyl Donors (1998) (37)
- Synthesis of competent nucleophiles for delivering the A ring of taxol (1993) (37)
- Intramolecular Diels–Alder Reactions of Cycloalkenones: Stereoselectivity, Lewis Acid Acceleration, and Halogen Substituent Effects (2014) (37)
- A ready synthesis of intermediates containing the A-ring substructure of taxol : a Diels-Alder route to the B-seco taxane series (1992) (37)
- Letter: The pyridine route to optically active estrone and 19-norsteroids. (1975) (37)
- Coupling Of Glycals: A New Strategy For The Rapid Assembly Of Oligosaccharides (1989) (36)
- A new strategy for the synthesis of spiroketals (1983) (36)
- Synthesis of the macrolide core of migrastatin (2002) (36)
- Cycloaddition reactions of aromatic nitroso compounds with oxygenated dienes. An approach to the synthesis of the FR-900482 family of antibiotics (1991) (36)
- The Synthesis of CP‐263,114 and CP‐225,917: Striking Long‐Range Stereocontrol in the Fashioning of C7 (2000) (36)
- A direct route to fluostatin C by a fascinating Diels-Alder reaction. (2008) (36)
- Total synthesis of peribysin E necessitates revision of the assignment of its absolute configuration. (2007) (36)
- Control of remote relative chiralities: a stereospecific total synthesis of dl-widdrol (1980) (36)
- The B‐Alkyl Suzuki—Miyaura Cross‐Coupling Reaction: Development, Mechanistic Study, and Applications in Natural Product Synthesis (2010) (36)
- A concise synthesis of a highly functionalized C-aryl taxol analog by an intramolecular Heck olefination reaction (1993) (35)
- Structure-activity profiles of eleutherobin analogs and their cross-resistance in Taxol-resistant cell lines (1999) (35)
- THE PYRIDINE ROUTE TO OPTICALLY ACTIVE ESTRONE AND 19-NORSTEROIDS (1975) (35)
- En route to a plant scale synthesis of the promising antitumor agent 12,13-desoxyepothilone B. (2000) (35)
- Therapeutic cure against human tumor xenografts in nude mice by a microtubule stabilization agent, fludelone, via parenteral or oral route. (2005) (35)
- On the Preparation of Enantiomerically Pure Isonitriles from Amino Acid Esters and Peptides. (2009) (35)
- Synthesis of the Calicheamicin Aryltetrasaccharide Domain Bearing a Reducing Terminus: Coupling of Fully Synthetic Aglycone and Carbohydrate Domains by the Schmidt Reaction (1992) (35)
- The total synthesis of (.+-.)-N-acetylneuraminic acid (NANA). A remarkable hydroxylation of a (Z)-enoate (1986) (35)
- Investigation of antitumor effects of synthetic epothilone analogs in human myeloma models in vitro and in vivo. (2005) (35)
- Diels-Alder reactions of 1,1-dimethoxy-3-trimethylsilyloxy-1,3-butadiene (1978) (34)
- Application of the glycal assembly strategy to the synthesis of a branched oligosaccharide: the first synthesis of a complex saponin (1993) (34)
- Total synthesis of lactonamycinone. (2003) (34)
- The Total Synthesis of (±)‐Mitomycin K (1992) (34)
- A Simple Method for the Conversion of Carboxylic Acids into Thioacids with Lawesson's Reagent. (2009) (34)
- Mechanistic variations in the Lewis acid-catalyzed cyclocondensation of siloxydienes with aldehydes (1982) (34)
- Efficient preparation of intermediates corresponding to C22-C27 and C28-C34 of FK-506 (1990) (34)
- A remarkable cyclopropanation: the total synthesis of myrocin C (1992) (34)
- Ring construction through transpositions of activated cyclopropanes (1974) (34)
- Synthesis and biological evaluation of DE-AB-camptothecin. (1974) (34)
- Improved dienophilicity of nitrocycloalkenes: prospects for the development of a trans-Diels-Alder paradigm. (2009) (33)
- Potent reversal of multidrug resistance by ningalins and its use in drug combinations against human colon carcinoma xenograft in nude mice (2005) (33)
- On the use of the imine-diene cyclocondensation reaction in the synthesis of yohimbine congeners (1985) (33)
- A total synthesis of N-acetylactinobolamine (1985) (33)
- Torsional steering controls the stereoselectivity of epoxidation in the guanacastepene a synthesis. (2006) (33)
- A practical total synthesis of globo-H for use in anticancer vaccines. (2009) (33)
- Studies directed toward the total synthesis of lactonamycin: control of the sense of cycloaddition of a quinone through directed intramolecular catalysis. (2003) (33)
- Toward the total synthesis of maoecrystal V: an intramolecular Diels-Alder route to the maoecrystal V pentacyclic core with the appropriate relative stereochemistry. (2011) (33)
- Synthesis and conformational analysis of (E)-9,10-dehydroepothilone B: a suggestive link between the chemistry and biology of epothilones. (2003) (33)
- Total Syntheses of CP-225,917 and CP-263,114: Creation of a Matrix Structure By Sequential Aldol Condensation and Intramolecular Heck Ring Closure (1998) (32)
- Total synthesis of phalarine. (2007) (32)
- An unexpected sialylation: Total syntheses of GM4 and a positional isomer (1993) (32)
- Stereospecific Sulfur-Mediated Cleavage of a Spirocyclobutanone: Synthesis of a Fully Functional Precursor to the CP Compounds. (1999) (32)
- Modeling of the electrophilic activation of mitomycins: chemical evidence for the intermediacy of a mitosene semiquinone as the active electrophile (1987) (32)
- Stereoselective routes to the C10−C19 fragment of FK-506 (1990) (32)
- Synthesis of selected LeY and KH-1 analogues: a medicinal chemistry approach to vaccine optimization. (2005) (32)
- The origin of endo stereoselectivity in the hetero-Diels-Alder reactions of aldehydes with ortho-xylylenes: CH-pi, pi-pi, and steric effects on stereoselectivity. (2002) (32)
- Synthesis of non-natural glycosylamino acids containing tumor-associated carbohydrate antigens (2003) (32)
- On the introduction of a trifluoromethyl substituent in the epothilone setting: chemical issues related to ring forming olefin metathesis and earliest biological findings. (2002) (32)
- From Glycals to Glycopeptides: A Convergent and Stereoselective Total Synthesis of a High Mannose N‐Linked Glycopeptide (2001) (31)
- A Phase I Study of Unimolecular Pentavalent (Globo-H-GM2-sTn-TF-Tn) Immunization of Patients with Epithelial Ovarian, Fallopian Tube, or Peritoneal Cancer in First Remission (2016) (31)
- Diels-Alder route to cis-fused .DELTA.1-3-octalones (1975) (31)
- A total synthesis of the methyl glycoside of ganglioside GM(1). (2000) (31)
- Applications of total synthesis toward the discovery of clinically useful anticancer agents. (2007) (31)
- Intramolecular Diels-Alder reactions of cycloalkenones: translation of high endo selectivity to trans junctions. (2012) (31)
- Studies in the benzannulation of a cycloalkynone: an approach to the synthesis of antibiotics containing the benz[a]anthracene core structure (1992) (31)
- Letter: A remarkable epoxide opening. An expeditious synthesis of vernolepin and vernomenin. (1976) (31)
- Construction of carbohydrate-based antitumor vaccines: synthesis of glycosyl amino acids by olefin cross-metathesis (2002) (31)
- Total synthesis of (+)-isomigrastatin. (2007) (31)
- A Fully Synthetic Route to the Neurotrophic Illicinones by Sequential Aromatic Claisen Rearrangements (1998) (31)
- Specific directing effects in the opening of vicinal hydroxy epoxides (1977) (30)
- ON THE REMARKABLE PROPENSITY FOR CARBON-CARBON BOND CLEAVAGE REACTIONS IN THE C2-C10 REGION OF FK-506 (1991) (30)
- Total synthesis of glycosylated proteins. (2015) (30)
- A new model for the presentation of tumor-associated antigens and the quest for an anticancer vaccine: a solution to the synthesis challenge via ring-closing metathesis. (2009) (30)
- Total synthesis of vineomycin B2 aglycon (1984) (30)
- A fully synthetic route to hikosamine (1985) (30)
- Total synthesis of the angiotensin-converting enzyme inhibitor A58365A: On the use of pyroglutamate as a chiral educt (1989) (30)
- Model studies directed toward the avermectins: A route to the spiroketal subunit (1987) (30)
- Total synthesis and antitumor activity of 12,13-desoxyepothilone F: an unexpected solvolysis problem at C15, mediated by remote substitution at C21. (2000) (30)
- An interesting issue of Diels-Alder selectivity discovered en route to 11-O-debenzoyltashironin. (2006) (29)
- Total Chemical Synthesis and Folding of All-l and All-d Variants of Oncogenic KRas(G12V). (2017) (29)
- Synthesis of Asialo GM1. New Insights in the Application of Sulfonamidoglycosylation in Oligosaccharide Assembly: Subtle Proximity Effects in the Stereochemical Governance of Glycosidation (1998) (29)
- A systematic degradation of zincophorin: a stereoselective synthesis of the C17-C25 fragment (1986) (29)
- Asymmetric induction via a catalytic antibody (1991) (29)
- A concise route to the core pentasaccharide of N-linked glycoproteins (2003) (29)
- Efficient asymmetric synthesis of radicicol dimethyl ether: a novel application of ring-forming olefin metathesis. (2000) (29)
- On the Lewis acid catalyzed cyclocondensation of silyloxydienes with .alpha.,.beta.-unsaturated aldehydes (1982) (29)
- Total syntheses of tumor-related antigens N3: probing the feasibility limits of the glycal assembly method. (2001) (29)
- Synthesis of disodium prephenate and disodium epiprephenate. Stereochemistry of prephenic acid and an observation on the base-catalyzed rearrangement of prephenic acid to p-hydroxyphenyllactic acid (1979) (29)
- Highly selective Diels-Alder reactions of directly connected enyne dienophiles. (2007) (29)
- Chemical biology of glycoproteins: From chemical synthesis to biological impact. (2019) (29)
- Effects of substituents on the nucleophilic ring opening of activated cyclopropanes (1975) (29)
- Defining the Molecular Recognition of MBr1 (Human Breast Cancer) Antigen by the MBr1 Antibody through Probe Structures Prepared by Total Synthesis (1995) (29)
- The synthesis and preliminary biological evaluation of a novel steroid with neurotrophic activity: NGA0187. (2005) (28)
- Amidoglycosylation of Polymer-Bound Glycals: A Complete Solid-Phase Synthesis of the Oligosaccharide Domain of the Lewisb Blood Group Determinant. (1998) (28)
- Total synthesis and structural revision of (+/-)-tricholomalides A and B. (2009) (28)
- Stereocontrolled Syntheses of C-Aryl Taxanes By Intramolecular Heck Olefination. Novel Instances of Diastereofacial Guidance By Proximal Coordination (1995) (28)
- A total synthesis of magallanesine: DMF acetal mediated cyclodehydration of a methyl ketone thioimide (1989) (28)
- On the total synthesis and determination of the absolute configuration of rishirilide B: exploitation of subtle effects to control the sense of cycloaddition of o-quinodimethides. (2003) (27)
- Constructing an adenocarcinoma vaccine: Immunization of mice with synthetic KH‐1 nonasaccharide stimulates anti‐KH‐1 and anti‐Ley antibodies (2002) (27)
- A core system that simulates the cycloaromatization and DNA cleavage properties of calicheamicin-esperamicin: a correlation experiment (1989) (27)
- Chemical Synthesis of the β-Subunit of Human Luteinizing (hLH) and Chorionic Gonadotropin (hCG) Glycoprotein Hormones (2014) (27)
- Halocycloalkenones as Diels-Alder dienophiles. Applications to generating useful structural patterns. (2013) (27)
- Simplified Synthetic TMC‐95A/B Analogues Retain the Potency of Proteasome Inhibitory Activity (2003) (26)
- Evaluation of Diene hierarchies for Diels--Alder reactions en route to xestocyclamine A: elaboration of an Ansa bridge by B-alkyl Suzuki macrocyclization. (2002) (26)
- Total synthesis of octosyl acid A. Intramolecular Williamson reaction via a cyclic stannylene derivative (1988) (26)
- On the relationship of topological and diastereofacial control in the Lewis acid catalyzed cyclocondensation reaction of alkoxyaldehydes with activated dienes: metal tunable asymmetric induction (1984) (26)
- The total synthesis of (+/-)-merrilactone A. (2002) (26)
- On the use of the haloetherification method to synthesize fully functionalized disaccharides (1990) (26)
- A Direct Route from 1.alpha.,2.alpha.-Anhydroglucose Derivatives to .alpha.-Glucosides (1994) (26)
- Multiple chirality transfers in the enantioselective synthesis of 11-O-debenzoyltashironin. Chiroptical analysis of the key cascade. (2008) (26)
- Synthesis and cytotoxic evaluation of some cribrostatin-ecteinascidin analogues. (2008) (26)
- A new approach to polypropionates: routes to subunits of monensin and tirandamycin (1985) (26)
- A highly convergent synthesis of an N-linked glycopeptide presenting the H-type 2 human blood group determinant (2006) (26)
- A concise route to enantiomerically pure 2-arylcyclohexenones of relevance to the pancratistatin problem (1995) (26)
- A synthetic route to the tricarbonyl region of FK-506 (1989) (26)
- Installation of the allylic trisulfide functionality of the enediyne antibiotics. Thiol-induced reductive actuation of the Bergman process (1990) (26)
- DNA cross-linking by intermediates in the mitomycin activation cascade. (1989) (26)
- Functionalized alanes for the conversion of epoxides to trans-fused .gamma.-lactones (1976) (26)
- Catalysis of homo diels-alder reactions by Yb(fod)3 (1985) (25)
- Experimental modeling of the priming mechanism of the calicheamicin/esperamicin antibiotics: actuation by the addition of intramolecular nucleophiles to the bridgehead double bond (1989) (25)
- An oxidative dearomatization cyclization model for cortistatin A (2009) (25)
- .beta.-Chloroethyl vinyl ketone, a useful reagent for the facile construction of fused ring systems (1969) (25)
- Reaction of piperidone enamines with methyl .beta.-vinylacrylate. A route to quinolines and isoquinolines (1968) (25)
- Expanding the limits of isonitrile-mediated amidations: on the remarkable stereosubtleties of macrolactam formation from synthetic seco-cyclosporins. (2012) (25)
- Probing Cell Surface “Glyco-Architecture” through Total Synthesis. Immunological Consequences of a Human Blood Group Determinant in a Clustered Mucin-like Context (1999) (25)
- Designing synthetic vaccines for HIV (2015) (24)
- A SIMPLE SYNTHESIS OF DL-CHALCOSE (1982) (24)
- Mature Homogeneous Erythropoietin-Level Building Blocks by Chemical Synthesis: The EPO 114-166 Glycopeptide Domain, Presenting the O-Linked Glycophorin. (2006) (24)
- A rapid route to ergot precursors via aza-claisen rearrangement (1984) (24)
- A stereospecific synthesis of griseofulvin (1979) (24)
- Diastereofacial control in the Lewis acid catalyzed cyclocondensation reaction of aldehydes with activated dienes: a synthesis of the Mus musculus pheromone (1984) (24)
- An efficient stereoselective total synthesis of DL-sesquicillin, a glucocorticoid antagonist. (2002) (24)
- Mature homogeneous erythropoietin building blocks by chemical synthesis: the EPO 22–37 glycopeptide domain presenting the full N-linked dodecasaccharide (2006) (24)
- The direction of base-catalyzed aldol cyclization of 1,5 diketones (1976) (24)
- A Stereospecific Geminal Alkylation Scheme En Route To CP‐225, 917 and CP‐263,114 (1998) (24)
- Stereospecific total synthesis of dl-hastanecine and dl-dihydroxyheliotridane (1977) (24)
- Synthetic Glycopeptide-Based Vaccines (2006) (24)
- A totally synthetic route to lincosamine (1983) (24)
- Simultaneous determination of helical unwinding angles and intrinsic association constants in ligand-DNA complexes: the interaction between DNA and calichearubicin B. (1998) (23)
- Synthetic explorations in the saframycin-ecteinascidin series: construction of major chiral subunits through catalytic asymmetric induction (2000) (23)
- Total Synthesis of Spirotenuipesines A and B (2007) (23)
- Total synthesis of pretyrosine (arogenate) (1981) (23)
- Expeditious routes to multiply functionalized pyrans (1984) (23)
- Synthetic explorations in the saframycin-ecteinascidin series: construction of major chiral subunits through catalytic asymmetric induction (2000) (23)
- Antibodies Against Specific MUC16 Glycosylation Sites Inhibit Ovarian Cancer Growth. (2017) (23)
- HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope (2018) (23)
- Advances in the development of convergent schemes for the synthesis of biologically important glycoconjugates (1995) (22)
- Engineering of therapeutic polypeptides through chemical synthesis: early lessons from human parathyroid hormone and analogues. (2012) (22)
- A stereoselective totally synthetic route to methyl .alpha.-peracetylhikosaminide (1989) (22)
- A Novel Intramolecular Heck Reaction: Synthesis of a Cholesterol ‐ Baccatin III Hybrid (1995) (22)
- Probing the stability of nonglycosylated wild-type erythropoietin protein via reiterative alanine ligations (2012) (22)
- Total Synthesis of Spirotryprostatin A, Leading to the Discovery of Some Biologically Promising Analogues. (1999) (22)
- Total synthesis of (+)-suaveolindole: establishment of its absolute configuration. (2007) (22)
- Concise synthesis of a lactonamycin model system by diastereoselective dihydroxylation of a highly functionalized naphthoquinone. (2001) (22)
- A straightforward route to functionalized trans-Diels-Alder motifs. (2010) (22)
- Total synthesis of dl-tazettine and 6a-epipretazettine: a formal synthesis of dl-pretazettine. Some observations on the relationship of 6a-epipretazettine and tazettine (1982) (21)
- A useful α, α′ - annulation reaction of enamines (1998) (21)
- Simple synthetic route to lasiodiplodin (1979) (21)
- Chemistry as an expanding resource in protein science: fully synthetic and fully active human parathyroid hormone-related protein (1-141). (2012) (21)
- On the acetoxylation of 2,3-dihydro-4-pyrones: a concise, fully synthetic route to the glucal stereochemical series (1985) (21)
- The Reaction of Enamines with Activated Butadienes. A One-Step Synthesis of Benzenes1 (1965) (21)
- Second generation epothilones: Discovery of fludelone and its extraordinary antitumor properties (2005) (21)
- An approach to the synthesis of carbon-carbon linked disaccharides (1984) (21)
- Total synthesis of garsubellin A. (2005) (21)
- Model studies directed toward the avermectins: A route to the oxahydrindene subunit (1987) (21)
- On the emerging role of chemistry in the fashioning of biologics: synthesis of a bidomainal fucosyl GM1-based vaccine for the treatment of small cell lung cancer. (2009) (21)
- Degradation of rapamycin : synthesis of a rapamycin derived fragment containing the tricarbonyl and triene sectors (1993) (21)
- A general route to 1-alkoxy-3-[(trimethylsilyl)oxy]-1,3-butadienes: vinylogous transesterification (1984) (21)
- A Highly Stereoselective Total Synthesis of Hispidospermidin: Derivation of a Pharmacophore Model (2000) (21)
- Human Cancer Antigen Globo H Is a Cell-Surface Ligand for Human Ribonuclease 1 (2015) (21)
- A NEW POLYMER SUPPORT SILYLENE LINKING METHOD FOR HINDERED HYDROXYL-BEARING SYSTEMS (1999) (21)
- A route to cyclic peptides and glycopeptides by native chemical ligation using in situ derived thioesters (2006) (21)
- Enediyne Quinone Imines: Truncated, Biologically Active Dynemicin Congeners (1995) (21)
- Synthesis of granulocyte–macrophage colony-stimulating factor as homogeneous glycoforms and early comparisons with yeast cell-derived material (2014) (20)
- The solution to a deep stereochemical conundrum: studies toward the tetrahydroisoquinoline alkaloids. (2006) (20)
- Efficient Synthesis of a Novel Resorcyclide as Anticancer Agent Based on Hsp90 Inhibition. (2008) (20)
- Regiospecific synthesis of isogabaculine (1979) (20)
- A synthetic route to valienamine: An interesting observation concerning stereoelectronic preferences in the SN2′ reaction (1994) (20)
- A novel photochemical route to the mitomycin and FR-900482 series (1991) (20)
- Studies directed toward the synthesis of terreulactone A: rapid construction of the A, B, C rings. (2006) (20)
- Studies directed toward the synthesis of the guanidine alkaloid, spiroleucettadine: some observations at the level of structure (2006) (20)
- Olefin Cross‐Metathesis: A Powerful Tool for Constructing Vaccines Composed of Multimeric Antigens (2005) (20)
- Bis annelation with 6-vinyl-2-picoline (1968) (20)
- A Three-Step Entry to the Aspirochlorine Family of Antifungal Agents. (2000) (20)
- Origins of the regioselectivities in the Diels-Alder reactions of vinylindenes with 1,4-quinone monoketal and acrolein dienophiles. (2009) (20)
- The total synthesis of spirotenuipesines A and B. (2007) (19)
- Solid-phase peptide synthesis and solid-phase fragment coupling mediated by isonitriles (2013) (19)
- Toward a Prostate Specific Antigen-Based Prostate Cancer Diagnostic Assay: Preparation of Keyhole Limpet Hemocyanin -Conjugated Normal and Transformed Prostate Specific Antigen Fragments (2008) (19)
- Organic synthesis in pursuit of immunology: large-scale synthesis of peracetylated GM2 glycosylamino acid for preparation of a multiantigenic prostate cancer vaccine. (2005) (19)
- Approaches to the synthesis of the mitomycins. A route to the mitosanes involving activated cyclopropanes (1981) (19)
- A Highly Convergent Synthesis of the Lewisy Blood Group Determinant in Conjugatable Form (1994) (19)
- Regiospecific Michael reactions to an enedione (1981) (19)
- On the total synthesis and preliminary biological evaluations of 15(R) and 15(S) aza-dEpoB: a Mitsunobu inversion at C15 in pre-epothilone fragments. (2000) (19)
- Conversion of androstenolone to pregnenolone. (1975) (19)
- Reiterative cysteine-based coupling leading to complex, homogeneous glycopeptides (2006) (19)
- Characterization of a mouse monoclonal IgG3 antibody to the tumor-associated globo H structure produced by immunization with a synthetic glycoconjugate (1998) (19)
- Degradation and manipulations of the immunosuppressant FK506: preparation of potential synthetic intermediates (1989) (19)
- Reactions of 3,4-benzopyrrolidinones with .beta.-ketoesters (1975) (19)
- Synthesis and a Preliminary DNA Binding Study of Hybrids of the Carbohydrate Domain of Calicheamicin γ 1I and the Aglycone of Daunorubicin: Calichearubicins A and B (1996) (19)
- On the DNA Recognition Role of the Carbohydrate Sector in Calicheamicin: A Comparison of DNA Cleaving Capacity of Enantiomeric Calicheamicinones (1994) (19)
- Reducing oligosaccharides via glycal assembly: on the remarkable stability of anomeric hydroxyl groups to global deprotection with sodium in liquid ammonia (2002) (18)
- On the mode of action of myrocin C: Evidence for a CC-1065 connection (1993) (18)
- Synthetic studies toward (+)-cortistatin A. (2011) (18)
- Degradation of rapamycin: Retrieval of major intact subunits. (1992) (18)
- Diels-Alder reactions of o-benzoquinones (1974) (18)
- Biomimetic total synthesis of tricycloillicinone and mechanistic studies toward the rearrangement of prenyl phenyl ethers. (2008) (18)
- En route to the total synthesis of tashironin: on the exercise of stereochemical control by a methyl group in mediating remote cyclization reactions (2005) (18)
- Toward the synthesis of xestocyclamine A: investigation of double Michael reaction and direct aza Diels–Alder reaction (2006) (18)
- A Diels-Alder route to functionalized cyclohexadienones (1977) (18)
- Studies in the synthesis of vernolepin. A Diels-Alder approach to the angularly functionalized AB system. (1976) (18)
- Straightforward synthesis of 1,2,3-tricarbonyl systems (1991) (18)
- Esperamicin A1 Intercalates into Duplex DNA from the Minor Groove (1994) (18)
- Chemical synthesis of the ATAD2 bromodomain (2014) (18)
- On the synthesis of conformationally modified peptides through isonitrile chemistry: implications for dealing with polypeptide aggregation. (2011) (18)
- Thio-mediated two-component coupling reaction of carboxylic acids and isonitriles under mild conditions. (2009) (18)
- Binding affinity and site selectivity of daunomycin analogues. (1994) (18)
- Chemistry and biology in search of antimetastatic agents. (2007) (18)
- Revisiting oxytocin through the medium of isonitriles. (2012) (18)
- Probing the SAR of dEpoB via chemical synthesis: a total synthesis evaluation of C26-(1,3-dioxolanyl)-12,13-desoxyepothilone B. (2002) (17)
- Thio-mediated synthesis of derivatized N-linked glycopeptides using isonitrile chemistry. (2009) (17)
- New syntheses of the novel immunoactivator FR900483 (1990) (17)
- Degradative routes to electrophilic CD-substructures of taxol (1993) (17)
- Confirmation of the Structures of Synthetic Derivatives of Migrastatin in the Light of Recently Disclosed Crystallographically Based Claims. (2010) (17)
- Nucleophilic additions to allenes. New synthesis of .alpha.-pyridones (1971) (17)
- Substrate specificity in enzymatically mediated trans acetylation reactions of calicheamicinone intermediates (1991) (17)
- The reaction of enamines with activated cyclopropanes (1966) (17)
- Generation and carbonyl addition reactions of Z-dilithiohex-3-ene-1,5-diyne (1988) (17)
- (3R, 9R, 10R)-Panaxytriol: A molecular-based nutraceutical with possible application to cancer prevention and treatment. (2008) (17)
- Pyridine route to .alpha.-substituted cyclohexenones (1975) (17)
- On the use of deuterium isotope effects in chemical synthesis (2002) (17)
- Stereospecific allylation of ribo and galacto aldosulose derivatives (1985) (17)
- Stereoselective reactions of alkenylpyranosides: the effect of double bond geometry on conformation (1988) (17)
- Studies toward the total synthesis of pluraflavin A. (2014) (16)
- Novel synthetic approach to the 8,10-dimethyl anti-syn-anti-perhydrophenanthrene skeleton. (2003) (16)
- A remarkable stereochemical inversion in some Heck arylation reactions. A mechanistic proposal (1994) (16)
- Multiple condensations with methyl .beta.-vinylacrylate (1973) (16)
- Conjugate and Diels-Alder reactions of an activated allylidenedithiane (1976) (16)
- Diels-Alder reactions of o-benzoquinones. A route to derivatives of .DELTA.2-1-octalone (1976) (16)
- Regioselective imide reduction : An issue in the total synthesis of staurosporine (1994) (16)
- Enantiomerically homogeneous intermediates toward the synthesis of descarbamoylcalicheamicinone (1991) (16)
- Induction of chemoprotective phase 2 enzymes by ginseng and its components. (2009) (16)
- Total synthesis of disodium prephenate. (1977) (16)
- Complex Target‐Oriented Synthesis in the Drug Discovery Process: A Case History in the dEpoB Series (2000) (16)
- Direct Epoxidation of Glycals: Application of a Reiterative Strategy for the Synthesis of β-Linked Oligosaccharides. (1989) (16)
- Enantioselective synthesis of protected forms of (3R,5R)-5-hydroxypiperazic acid useful for synthesis (2000) (15)
- The total synthesis of renierone (1981) (15)
- A mercury mediated route to the mitosenes (1982) (15)
- Coupling reactions of hindered isonitriles and hindered alkyl thioacids: Mechanistic studies. (2009) (15)
- Noncatalytic reaction of isonitriles and carboxylic acids en route to amide-type linkages (2008) (15)
- Total Syntheses of Epothilones A and B. (1998) (15)
- A Novel Type of Alkyl Shift (1962) (15)
- An approach to the synthesis of the naphthyridinomycin alkaloids: The synthesis of two subunits (1984) (15)
- Regiospecificity in the Diels-Alder reactions of an enedione (1981) (15)
- Chemo- and stereoselective epoxidation of 12,13-desoxyepothilone B using 2,2′-dimethyldioxirane (2001) (15)
- A novel face specific Mannich closure providing access to the saframycin-ecteinascidin series of piperazine based alkaloids (2000) (15)
- Intramolecular homoconjugate addition. Simple entry to functionalized pyrrolizidines and indolizidines (1974) (15)
- Enzymatic resolution of racemic glycals : an application of the wong acylation method (1991) (15)
- Regiospecific ureidoalkylation of silyl enol ethers (1980) (15)
- Creating quaternary centers with high exo stereoselectivity using activated alpha-alkynyl dienophiles. (2007) (15)
- THE FIRST SUCCESSFUL INTRAMOLECULAR DIELS-ALDER REACTION LEADING TO A BACCATIN III CONSTRUCT BEARING OXYGEN FUNCTIONALITY AT C10 (1995) (14)
- Glycopeptides and glycoproteins : synthesis, structure, and application (2007) (14)
- Diels-Alder reactions of .alpha.-phenylsulfinylmethylenecarbonyl compounds. The synthesis of disodium prephenate dimethyl acetal (1977) (14)
- Iterative Assembly of Glycate and Glycal Derivatives: The Synthesis of Glycosylated Natural Products and Complex Oligosaccharides (2008) (14)
- "Biologic" level structures through chemistry: A total synthesis of a unimolecular pentavalent MUCI glycopeptide construct. (2009) (14)
- Conformational locking through allylic strain as a device for stereocontrol--total synthesis of grandisine A. (2007) (14)
- The synthesis and evaluation of 12,13-benzodesoxyepothilone B: A highly convergent route (1999) (14)
- An advanced dynemicin A model: Stabilization of the 3,8-epoxide by anthraquinone functionality in the absence of the bridging enediyne (1994) (14)
- Interaction of calicheamicin γ1I and its related carbohydrates with DNA–protein complexes (1999) (14)
- An application of the suárez reaction to the regiospecific and stereospecific synthesis of the C28-C42 segment of rapamycin (1993) (14)
- Synthetic studies in the mevinoid field. The total synthesis of ML236A (1988) (14)
- Mechanism of cis-enamide formation from N-(alpha-silyl)allyl amides: synthetic potential of stepwise dyotropic rearrangements. (2003) (14)
- Multifaceted cytoprotection by synthetic polyacetylenes inspired by the ginseng-derived natural product, panaxytriol (2011) (14)
- A Diels-Alder Route to Angularly Functionalized Bicyclic Structures. (2010) (14)
- Novel construction of steroid skeleton. Utility of di-tert-butyl acetonedicarboxylate (1971) (14)
- On the reaction of leucomitosenes with osmium tetraoxide. A route to novel mitomycins (1988) (14)
- Fully Synthetic Granulocyte Colony-Stimulating Factor Enabled by Isonitrile-Mediated Coupling of Large, Side-Chain-Unprotected Peptides. (2015) (14)
- Concise Synthesis of the Xenibellols Core. (2009) (13)
- Antarafacial mediation of oxygen delivery by a phenylsulfinyl group in the epoxidation of proximal double bonds: intramolecular trapping of an early Pummerer intermediate with stereoelectronic control. (2011) (13)
- Synthesis of the pentasaccharide core structure of asparagine-linked glycoprotein oligosaccharides by the glycal assembly method. (1996) (13)
- On the mechanism of the lewis acid catalyzed cyclocondensation of aldehydes with siloxydienes (1982) (13)
- Total synthesis of dl-tazettine (1980) (13)
- On the Conformations of Halichlorine and the Pinnaic Acids: Nitrogen Inversion as a Possible Determinant of Biological Profile (2000) (13)
- Toward a potential total synthesis of gelsemine: A regioselective hydroboration directed by a remote olefin (1998) (13)
- On the synthesis and extraordinary configurational stability of the C9a-hydroxylated mitomycins in the 10-decarbamoyloxy-9-dehydro series: fully synthetic routes to novel mitomycin congeners (1988) (13)
- An application of the ireland reaction to the stereospecific synthesis of fused carbocyclic systems. (1988) (13)
- Hydroxynorleucine as a glycosyl acceptor is an efficient means for introducing amino acid functionality into complex carbohydrates (2003) (13)
- A stereospecific 2+2+2 annulation (1983) (13)
- Permuting Diels-Alder and Robinson Annulation Stereopatterns. (2012) (13)
- The cyclopropane route to trans-fused .gamma.-lactones (1976) (13)
- Stereospecific syntheses of coriolin, coriolin B and diketocoriolin B (1980) (13)
- A ready synthesis of (±)-D-homo-oestrone (1972) (13)
- Total Chemical Synthesis of Human Thyroid-Stimulating Hormone (hTSH) β-Subunit: Application of Arginine-tagged Acetamidomethyl (AcmR) Protecting Groups. (2018) (12)
- Staurosporine and ent-Staurosporine: The First Total Syntheses, Prospects for a Regioselective Approach, and Activity Profiles. (1996) (12)
- The Potential of Natural Products in the Discovery of Pharma Leads: A Case for Reassessment (2010) (12)
- An application of the evans-prasad 1,3-syn diol synthesis to a stereospecific synthesis of the C10-C27 segment of rapamycin (1993) (12)
- A notable stereochemical variation in the 2+2+2 annulation reaction (1984) (12)
- Variations in the stereochemistry of the boron trifluoride mediated cyclocondensation reaction of aldehydes with siloxy dienes (1985) (12)
- A Useful Divinyl Ketone Equivalent (1978) (12)
- Synthetic and Immunological Studies on Clustered Modes of Mucin‐Related Tn and TF O‐Linked Antigens: The Preparation of a Glycopeptide‐Based Vaccine for Clinical Trials Against Prostate Cancer. (1999) (12)
- Promising agents at the interface of biology and oncology derived through chemical synthesis (2007) (12)
- Dianion equivalents corresponding to the polypropionate domain of epothilone B (1999) (12)
- An entry to the ring B:ring C bishydroquinone leucodaumomycin series containing an intact carbohydrate (1991) (11)
- A remarkable pyranose to furanose isomerization mediated by an “anomeric" silyloxy function (1999) (11)
- Total Synthesis and Proof of Structure of a Human Breast Tumor (Globo‐ H) Antigen (1997) (11)
- Remote Effects in Macrolide Formation Through Ring-Forming Olefin Metathesis: An Application to the Synthesis of Fully Active Epothilone Congeners. (1997) (11)
- The total synthesis of racemic patchouli and epi-patchouli alcohol (1968) (11)
- Lessons from the total synthesis of (±)-phalarine: Insights into the mechanism of the Pictet–Spengler reaction (2010) (11)
- A dramatic solvent effect in the Diels-Alder reactions of o-benzoquinones (1977) (11)
- Pattern recognition analysis in complex molecule synthesis and the preparation of iso-Diels–Alder motifs (2013) (11)
- A Fully Synthetic Route to Tunichminyluracil (X). (1986) (11)
- A protocol to accomplish ‘homo-Robinson’ annulation: application to the guanacastepene problem (2005) (10)
- A novel transformation in the quadrone series (1980) (10)
- The synthesis of a key intermediate en route to gelsemine: a program based on intramolecular displacement of the carbonoxygen bond of a strategic oxetane (2002) (10)
- A TOTAL SYNTHESIS OF A STAGE SPECIFIC PENTASACCHARIDE EMBRYOGENESIS MARKER (1995) (10)
- Probing the formation and chemistry of enoxyoxirane derivatives in the C-ring en route to guanacastepene (2004) (10)
- On the steric course of the reduction of 2-alkoxy-4-pyranones: a remarkable demonstration of anomeric control (1985) (10)
- Studies in the synthesis of a baccatin III-steroid hybrid : a remarkably rapid intramolecular Diels Alder reaction (1994) (10)
- On the conversion of 1-glutamate to 1-dopa (1981) (10)
- Total Synthesis of Allosamidin: An Application of the Sulfonamidoglycosylation of Glycals. (1991) (10)
- Syntheses of Isomerically Pure Reference Octalins and Hydrindanes. (2009) (10)
- The synthesis of polyoxygenated natural products via fully synthetic branched pyranose derivatives: application to the erythronolide problem (1989) (10)
- Diels-Alder routes to angularly halogenated cis-fused bicyclic ketones: Readily accessible cyclynone intermediates. (2010) (9)
- Toward Homogeneous Erythropoietin: Application of Metal Free Dethiylation in the Chemical Synthesis of the Ala79-Arg166 Glycopeptide Domain. (2011) (9)
- Stereocontrolled Total Synthesis of Hispidospermidin (1997) (9)
- A strategy for probing the autonomy of cross-domain stereochemical communication in glycoconjugates. (2001) (9)
- Synthetic Carbohydrate‐Based Vaccines (2005) (9)
- In pursuit of an anticancer vaccine: a monomolecular construct containing multiple carbohydrate antigens (2000) (9)
- Route to furanoid system by intramolecular homoconjugate addition (1974) (9)
- An anomalous mannich reaction of a trimethylsilyl enol ether (1982) (9)
- The synthesis of (±)-gelsemine (2002) (9)
- Intramolecular opening of an activated vinylcyclopropane: an entry to the bicyclo[3,3,0]octenone series (1975) (9)
- Ring-opening of diethyl 2-vinylcyclopropane-1,1-dicarboxylate (1972) (9)
- Synthesis of dl-epigriseofulvin (1978) (9)
- Studies directed toward the total synthesis of acarbose : the trisaccharide domain (1994) (9)
- Cascade resulting in the reductive ethynylation of aldehydes: dissection of its components. (2010) (9)
- Synthetic Development of Radicicol and Cycloproparadicicol: Highly Promising Anticancer Agents Targeting Hsp90 (2004) (8)
- Stereospecific synthesis and ring closure of a racemic actinospectose equivalent: a concise route to the spectinomycin series (1986) (8)
- Total synthesis of 13-oxygenated prostanoids derived from arachidonate: an instance of extraordinary variability in the stereochemical sense of a Mukaiyama aldol reaction (1989) (8)
- Reactions of methyl β-vinylacrylate with β-dicarbonyl compounds--a new route to functionalized bridged ring systems (1968) (8)
- A Convergent Total Synthesis of Calicheamicin γI 1. (1994) (8)
- Phase I clinical, pharmacokinetic, and pharmacodynamic study of KOS-862 (Epothilone D) in patients with advanced solid tumors and lymphoma (2012) (8)
- The Methylation of 1,2-Diarylethylenes by Dimethylsulfinyl Carbanion (1966) (8)
- Synthesis and biological activity in the camptothecin series (1973) (8)
- A Paradigm Case for the Merging of Glycal and Enzymatic Assembly Methods in Glycoconjugate Synthesis: A Highly Efficient Chemo‐Enzymatic Synthesis of GM3 (1996) (8)
- Remarkable stability of derivatives of leucomitomycin F. Novel mitomycin analogs (1987) (8)
- SYNTHESIS AND BIOLOGICAL EVALUATION OF DE-AB-CAMPTOTHECIN (1975) (8)
- Total Synthesis and Proof of Stereochemistry of Natural and Unnatural Pinnaic Acids: A Remarkable Long‐Range Stereochemical Effect in the Reduction of 17‐Oxo Precursors of the Pinnaic Acids (2001) (8)
- Concise Stereoselective Routes to Advanced Intermediates Related to Natural and Unnatural Pinnaic Acid (2001) (8)
- Lewis acid catalyzed cyclocondensations of formaldehyde with activated dienes: a direct route to pyranosidal pentoses (1984) (8)
- Preparation and reactions of a tris annelating agent (1974) (8)
- Defining the Molecular Recognition of Globo H (Human Breast Cancer) Antigen Through Probe Structures Prepared by Total Synthesis. (1996) (8)
- 1,7-Addition of enamines to 1,1-bisethoxycarbonyl-2-vinylcyclopropane: a useful method of introducing a six carbon fragment α to a ketone (1969) (8)
- Annulative route to enediones (1982) (7)
- Total Syntheses of KS‐501, KS‐502, and Their Enantiomers. (1992) (7)
- Subtle Variations in the Long-Range Transmission of Stereochemical Information: Matched and Mismatched Aldol Reactions This work was supported by the National Institutes of Health (Grant Nos. CA-28824 and HL-25848). (2000) (7)
- A mannich-like approach to naphthyridinomycin (1984) (7)
- Epoxides derived from pyranosyl dienes: Unusually stable glycosyl donors (1994) (7)
- An Approach to the Synthesis of Tricholomalide A: An Effective Means for Achieving Homo-Robinson Annulation. (2008) (7)
- Observations on the state of synthesis: Some magic moments revisited (1997) (7)
- Stereochemistry of the ring-opening of an activated vinylcyclopropane (1972) (7)
- Fluxional isomerism of a malonate anion – an instance of intramolecular homoconjugate addition (1973) (7)
- Cyclobutenone as a Highly Reactive Dienophile: Expanding Upon Diels—Alder Paradigms. (2010) (7)
- SOLID SUPPORT OLIGOSACCHARIDE SYNTHESIS AND COMBINATORIAL CARBOHYDRATE LIBRARIES (2003) (7)
- Ethol carbonates: weakly nucleophilic precursors of site-specific enolates (1982) (7)
- Total syntheses of polycyclic polyp renylated acylphloroglucinols (2010) (7)
- Specificity, Inhibition, and Synthetic Utility of a Recombinant Human . alpha.‐1,3‐Fucosyltransferase. (1992) (7)
- Catalytic antibodies and disfavored reactions. (1993) (7)
- REDUCTIVE DESILANOLATION AS A ROUTE TO BENZONITRILES. AN APPLICATION TO A CONCISE SYNTHESIS OF THE AROMATIC SECTOR OF CALICHEAMICIN (1994) (7)
- Polonovski reactions of mitosane derivatives (1987) (6)
- A route to functionalized mitosones (1977) (6)
- Exploration of Modalities in Building α-O-Linked Systems Through Glycal Assembly: A Total Synthesis of the Mucin-Related F1α Antigen. (1998) (6)
- Observations in the Chemistry and Biology of Cyclic Enediyne Antibiotics: Total Syntheses of Calicheamicin γI 1 and Dynemicin A (1996) (6)
- Polonovski reactions of mitosane derivatives (1987) (6)
- Further Expansion of the trans-Diels-Alder Paradigm: Reductive Alkylation of α-Cyanoketones. (2011) (6)
- A novel degradation in the avermectin series: A stereospecific osmylation reaction (1987) (6)
- Remarkable long range effects on the diastereoface selectivity in an aldol condensation (1999) (6)
- Nucleophilic additions to diethyl cyclopropylmethylidenemalonate (1974) (6)
- Enantiotopic Synthesis of Natural Products: Merrilactone and Guanacastepene (2005) (6)
- Applications of Total Synthesis to Problems in Neurodegeneration: Fascinating Chemistry Along the Way (2006) (6)
- Unrecognized benzoyl migrations in the lincosamine series: modeling of the electrophilic reactions of an alkenyl pyranoside (1987) (5)
- An Ionic Diels-Alder Route to cis-Fused Octalins Containing an All-Carbon Quaternary Stereocenter in an Angular Position. (2010) (5)
- First Total Synthesis of Staurosporine and ent‐Staurosporine. (1995) (5)
- Probing competitive pathways in building a hydroazulene moiety by reductive cyclization (2004) (5)
- A Rapid Total Synthesis of Spirotryprostatin B: Proof of Its Relative and Absolute Stereochemistry. (2000) (5)
- Coupling of Glycal Derived Thioethyl Glycosyl Donors with Glycal Acceptors. An Advance in the Scope of the Glycal Assembly. (1998) (5)
- Synthetic Carbohydrate-Based Antitumor Vaccines (2008) (5)
- Reductive cyclization of disubstituted pyridines and intramolecular aldolization of unsymmetrical diketones (1972) (5)
- Additions and Corrections - On the Addition of Allytrimethylsilane to Glycal Acetates. (1982) (5)
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- Asymmetric Synthesis of Merrilactone A (2010) (0)
- Intramolecular Cycloaddition Reactions of Dienyl Nitroso Compounds: Application to the Synthesis of Mitomycin K. (2010) (0)
- Toward a Potential Total Synthesis of Gelsemine: A Regioselective Hydroboration Directed by a Remote Olefin. (1998) (0)
- Terpenes and Related Structures (1971) (0)
- Total Syntheses of Polyprenylated Acylphloroglucinols (2010) (0)
- Synthesis of Spirotenuipesine A (2007) (0)
- A Formal Synthesis of FK-506. Exploration of Some Alternatives to Macrolactamization. (1990) (0)
- MULTIPLE KONDENSATIONEN MIT BETA-VINYL-ACRYLSAEUREMETHYLESTER (1973) (0)
- A Total Synthesis of N-Acetylactinobolamine (I). (1986) (0)
- NUCLEOPHILE ADDITION AN ALLENE, NEUE SYNTH. VON ALPHA-PYRIDONEN (1971) (0)
- A Fully Synthetic Route to the Neurotrophic Illicinones by Sequential Aromatic Claisen Rearrangement. (1999) (0)
- CYCLIZATIONS OF MERCURY AND PALLADIUM SUBSTITUTED ACRYLANILIDES (1983) (0)
- A ROUTE TO FUNCTIONALIZED MITOSANES (1977) (0)
- Vignette 3: Radicicol and the Epothilones: Total Synthesis of Novel Anticancer Agents Using Ring‐Closing Metathesis (2008) (0)
- Total Synthesis of (.+-.)-Heptelidic Acid. (1989) (0)
- Total Synthesis of (.+‐.)‐Dynemicin A. (1995) (0)
- Application of Hitherto Unexplored Macrocyclization Strategies in the Epothilone Series: Novel Epothilone Analogues by Total Synthesis. (2003) (0)
- Unrecognized Benzoyl Migrations in the Lincosamine Series: Modeling of the Electrophilic Reactions of an Alkenyl Pyranoside. (1987) (0)
- Epoxides Derived from Pyranosyl Dienes: Unusually Stable Glycosyl Donors. (2010) (0)
- Total Synthesis of Calicheamicinone: New Arrangements for Actuation of the Reductive Cycloaromatization of Aglycon Congeners. (1991) (0)
- Synthesis of the Functionalized Tricyclic Skeleton of Guanacastepene A (IV): A Tandem Epoxide‐Opening β‐Elimination/Knoevenagel Cyclization. (2002) (0)
- Stereoselective Route to the C10-C19 Fragment of FK-506. (1990) (0)
- Chemical Synthesis and Biological Studies of the Epothilones: Microtubule Stabilizing Agents with Enhanced Activity Against Multidrug-Resistant Cell Lines and Tumors (2002) (0)
- New endiyn-quinone and process for their preparation and use (1995) (0)
- Differentiation of Nonconventional “Carbanions” — The Total Synthesis of Nemorosone (I) and Clusianone (II). (2008) (0)
- A Concise Total Synthesis of Defucogilvocarcin V by Application of the Meyers Biaryl Strategy: Ortho- and Para-Selective Functionalizations of the A Ring. (1988) (0)
- The Total Synhesis of Dynemicin A Leading to Development of a Fully Contained Bioreductively Activated Enediyne Prodrug. (2010) (0)
- Highly Selective Diels—Alder Reactions of Directly Connected Enyne Dienophiles. (2007) (0)
- Degradative Routes to Electrophilic CD-Substructures of Taxol. (2010) (0)
- Construction of Carbohydrate-Based Antitumor Vaccines: Synthesis of Glycosyl Amino Acids by Olefin Cross-Metathesis. (2002) (0)
- Synthesis of (+)-Suaveolindole (2008) (0)
- Enhancing the Scope of the Diels—Alder Reaction Through Isonitrile Chemistry: Emergence of a New Class of Acyl-Activated Dienophiles. (2012) (0)
- Covers ion of amine to hydroxylamine (1991) (0)
- TOTAL SYNTHESIS OF DISODIUM PREPHENATE (1978) (0)
- Synthesis of Fluostatin C (2008) (0)
- Total Syntheses of (+)‐ and (‐)‐Peribysin E. (2009) (0)
- Total Synthesis of Gypsetin, Deoxybrevianamide E, Brevianamide E, and Tryprostatin B: Novel Constructions of 2,3-Disubstituted Indoles. (2000) (0)
- Abstract #5565: The therapeutic effects against refractory and multiple drug resistant xenograft tumors by the third generation microtubule targeting epothilone: Iso-oxazole-fludelone (2009) (0)
- ENOL CARBONATES: WEAKLY NUCLEOPHILIC PRECURSORS OF SITE-SPECIFIC ENOLATES (1982) (0)
- A Concise and Stereoselective Route to the Predominant Stereochemical Pattern of the Tetrahydropyranoid Antibiotics: An Application to Indanomycin. (1987) (0)
- Total Synthesis of Octosyl Acid A. Intramolecular Williamson Reaction via a Cyclic Stannylene Derivative. (1989) (0)
- The Total Synthesis of (.+-.)-Mitomycin K. (1992) (0)
- The Total Synthesis of (.+-.)-N-Acetylneuraminic Acid (NANA): A Remarkable Hydroxylation of a (Z)-Enoate. (1987) (0)
- Other Natural Products (1971) (0)
- On the Use of the Haloetherification Method to Synthesize Fully Functionalized Disaccharides. (1990) (0)
- Application of the Glycal Assembly Strategy to the Synthesis of a Branched Oligosaccharide: The First Synthesis of a Complex Saponin. (1994) (0)
- Cycloaddition Reactions of Aromatic Nitroso Compounds with Oxygenated Dienes. An Approach to the Synthesis of the FR-900482 Family of Antibiotics. (1991) (0)
- INTERCONVERSIONS OF BETA-DICARBONYL ANIONS THROUGH ACTIVATED CYCLOPROPANES (1975) (0)
- Abstract 3527: Therapeutic cure against five human xenograft tumors and strongly suppressed drug-resistant and refractory xenograft tumors in nude mice by the third generation epothilone: Iso-oxazole fludelone (2011) (0)
- Total Synthesis of dl-Indolizomycin. (1990) (0)
- Synthetic Studies towards Maoecrystal V. (2009) (0)
- Synthesis of Grandisine A (2008) (0)
- Preparation and Diels–Alder Reaction of a Highly Nucleophilic Diene: trans‐1‐Methoxy‐3‐Trimethylsiloxy‐1,3‐Butadiene and 5β‐Methoxycyclohexan‐1‐One‐3β,4β‐Dicarboxylic Acid Anhydride (2003) (0)
- A Concise Route to Enantiomerically Pure 2-Arylcyclohexenones of Relevance to the Pancratistatin Problem. (1995) (0)
- One part heat curable organopolysiloxane composition (1991) (0)
- Erratum to: Phase I clinical, pharmacokinetic, and pharmacodynamic study of KOS-862 (Epothilone D) in patients with advanced solid tumors and lymphoma (2011) (0)
- Development of a Fully Synthetic Stereoselective Route to 6-Deoxyerythronolide B (I) by Reiterative Applications of the Lewis Acid Catalyzed Diene Aldehyde Cyclocondensation Reaction: A Remarkable Instance of Diastereofacial Selectivi (1990) (0)
- In Pursuit of Carbohydrate‐Based HIV Vaccines. Part 2. The Total Synthesis of High‐Mannose‐Type gp120 Fragments — Evaluation of Strategies Directed to Maximal Convergence. (2004) (0)
- The Total Synthesis of (.+‐.)‐Merrilactone A. (2002) (0)
- A Novel α,β-Unsaturated Nitrone-aryne [3 + 2] Cycloaddition and Its Application in the Synthesis of the Cortistatin Core. (2009) (0)
- Synthesis of Immunomodulatory Marine Natural Products (2001) (0)
- Stereospecific Vorbrueggen-Like Reactions of 1,2-Anhydro Sugars. An Alternative Route to the Synthesis of Nucleosides. (1990) (0)
- Conversion of Biologically Interesting Amines to Hydroxylamines. (1990) (0)
- A Synthetic Route to Valienamine: An Interesting Observation Concerning Stereoelectronic Preference in the SN2′ Reaction. (1994) (0)
- Synthesis and Evaluation of Geldanamycin—Testosterone Hybrids. (2000) (0)
- Total Syntheses of CP‐225,917 and CP‐263,114: Creation of a Matrix Structure by Sequential Aldol Condensation and Intramolecular Heck Ring Closure. (1998) (0)
- Abstract 3521: Alleviation of cancer chemotherapeutic agent-induced toxicity by the synthetic panaxytriol analogues of Panax Ginseng (2011) (0)
- A Synthetic Pathway to Either Enantiomer of Merrilactone A (I). (2005) (0)
- Enantioselective Synthesis of the Oxadecalin Core of Phomactin A via a Highly Stereoselective Diels—Alder Reaction. (2002) (0)
- Total Synthesis as a Resource in Drug Discovery: The First in vivo Evaluation of Panaxytriol (I) and Its Derivatives. (2006) (0)
- The direction of enamine formation from 2-alkyl cycloalkanones - internal enamine formation (1965) (0)
- New Routes to Functionalized Benzazepine Substructures: A Novel Transformation of an α-Diketone Thioamide Induced by Trimethyl Phosphite. (1990) (0)
- Polonovski Reactions of Mitosane Derivatives. (1987) (0)
- A letter from Professor Samuel J. Danishefsky (2019) (0)
- Studies Directed Toward the Total Synthesis of Acarbose: The Trisaccharide Domain. (1994) (0)
- An Interactive Strategy for the Assembly of Complex, Branched Oligosaccharide Domains on a Solid Support: A Concise Synthesis of the Lewisb Domain in Bioconjugatable Form. (1994) (0)
- Studies in the Benzannulation of a Cycloalkynone: An Approach to the Synthesis of Antibiotics Containing the Benz(a)anthracene Core Structure. (1993) (0)
- Explorations in Organic Chemistry Leading to the Total Synthesis of (.+‐.)‐Gelsemine. (2010) (0)
- Glycoconjuges a specificite de sequence antagonistes de transcription (1994) (0)
- SYNTHETIC STUDIES TOWARD AFLAVININE: A SYNTHESIS OF 3-DEMETHYLAFLAVININE VIA A (2 + 2 + 2) ANNULATION (1985) (0)
- Preparation of Enantiomerically Pure Isonitriles from Amino Acid Esters and Peptides. (2009) (0)
- Total Synthesis of Heliquinomycinone. (2002) (0)
- Total Synthesis of Heliquinomycinone: Proof of Concept and Assembly of a Fully Mature Spirocyclization Precursor. (2002) (0)
- A Solid Support Synthesis and Novel Conjugation Methods of Breast Tumor Associated Antigen: Toward the Development of Cancer Vaccines (1998) (0)
- Total Synthesis of (.+-.)-Pancratistatin. (1989) (0)
- STEREOSPECIFIC 2 + 2 + 2 ANNULATION (1984) (0)
- Synthesis and Conformational Analysis of (E)‐9,10‐Dehydroepothilone B: A Suggestive Link Between the Chemistry and Biology of Epothilones. (2003) (0)
- Generation and Carbonyl Addition Reactions of Z-Dilithiohex-3-ene-1,5-diyne. (1989) (0)
- Experiments Directed Toward a Total Synthesis of Dynemicin A: A Solution to the Stereochemical Problem. (1994) (0)
- Advances in Brief Identification of a Geldanamycin Dimer That Induces the Selective Degradation of HER-Family Tyrosine Kinases 1 (2000) (0)
- AN EXPEDITIOUS SYNTHESIS OF ESTRONE (1976) (0)
- Total Synthesis of (‐)‐Epothilone B (VIII): An Extension of the Suzuki Coupling Method and Insights into Structure‐Activity Relationships of the Epothilones. (1997) (0)
- A Concise Total Synthesis of Dysidiolide Through Application of a Dioxolenium‐Mediated Diels—Alder Reaction. (1998) (0)
- Titelbild: At Last: Erythropoietin as a Single Glycoform (Angew. Chem. 46/2012) (2012) (0)
- The Synthesis of (.+‐.)‐Gelsemine. (2002) (0)
- Total Synthesis and Proof of Stereochemistry of Natural and Unnatural Pinnaic Acids: A Remarkable Long-Range Stereochemical Effect in the Reduction of 17-Oxo Precursors of the Pinnaic Acids. (2002) (0)
- Synthesis of Non‐Natural Glycosylamino Acids Containing Tumor‐Associated Carbohydrate Antigens. (2003) (0)
- A process for the preparation of allal glycals in and gulalserierne (1991) (0)
- Glycoconjugates glycoamino whose intermediates, and their use (2000) (0)
- Foreword by S. Danishefsky (2012) (0)
- Various mechanisms of immunosuppression " Removal " of tumor antigen from context of tumor cell Tumor Antigen Carrier / Immunostimulant Chemical synthesis Immunization " training phase " Activation (0)
- ISOCAMPTOTHECIN, SYNTHESIS AND BIOLOGICAL ACTIVITY IN THE CAMPTOTHECIN SERIES (1973) (0)
- Total Synthesis of (+)‐Halichlorine: An Inhibitor of VCAM‐1 Expression. (2010) (0)
- On the Synthesis and Extraordinary Configurational Stability of the C9a‐Hydroxylated Mitomycins in the 10‐Decarbamoyloxy‐9‐dehydro Series: Fully Synthetic Routes to Mitomycin Congeners. (1988) (0)
- On the Reaction of Leucomitosenes with Osmium Tetraoxide: A Route to Novel Mitomycins. (1988) (0)
- Studies Directed to the Total Synthesis of ET 743 (I) and Analogues Thereof: An Expeditious Route to the ABFGH Subunit (II). (2002) (0)
- Pharmacological evaluation of iso-oxazole-dehydelone as a potent third generation microtubule stabilization epothilone antitumor agent (2006) (0)
- A Concise Route to the Core Pentasaccharide of N‐Linked Glycoproteins. (2003) (0)
- Total Synthesis of Calicheamicinone: A Solution to the Problem of the Elusive Urethane. (1990) (0)
- SYNTHESIS OF VERNOLEPIN. DIELS-ALDER APPROACH TO THE ANGULARLY FUNCTIONALIZED AB SYSTEM (1976) (0)
- Synthesis of the Macrolide Core (I) of Migrastatin (II). (2003) (0)
- A Direct Route from 1α,2α-Anhydroglucose Derivatives to . alpha.-Glucosides. (1994) (0)
- Recent Departures in the Synthesis of Peptides and Glycopeptides (2010) (0)
- On the Use of the Imine-Diene Cyclocondensation Reaction in the Synthesis of Yohimbine Congeners. (1986) (0)
- Importance of the Stereochemistry at C10 in Governing the Feasibility of the Intramolecular Diels‐Alder Route to Baccatin III Constructs: Surprising Results in the 10R‐9‐Deoxy Series. (1995) (0)
- Peptides de liaison à hdc-sign (2012) (0)
- New Generation Taxoids and Hybrids of Microtuble-Stabilizing Anticancer Agents (2001) (0)
- Strategy in Oligosaccharide Synthesis: An Application to a Concise Total Synthesis of the KH-1(adenocarcinoma) Antigen. (1998) (0)
- Synthesis of epothilones, intermediates thereof, analogs and their use (2003) (0)
- CONVERSION OF ANDROSTENOLONE TO PREGNENOLONE (1975) (0)
- Stereocontrolled Syntheses of C‐Aryl Taxanes by Intramolecular Heck Olefination. Novel Instances of Diastereofacial Guidance by Proximal Coordination. (1995) (0)
- Synthesis of Ecteinascidin 743 (2006) (0)
- Total Synthesis of Gypsetin. (2010) (0)
- On the Communication of Chirality from Furanose and Pyranose Rings to Monosaccharide Side Chains: Anomalous Results in the Glucose Series. (1986) (0)
- INTRAMOLECULAR HOMOCONJUGATE ADDITION, A SIMPLE ENTRY TO FUNCTIONALIZED PYRROLIZIDINES AND INDOLIZIDINES (1974) (0)
- A Concise Route to the Calicheamicin-Esperamicin Series: The Crystal Structure of a Core Subunit. (1989) (0)
- Total Synthesis of (.+-.)-3-Demethoxyerythratidinone: Demonstration of a Radical Cyclization Route to a Site Specific Enol Derivative. (1987) (0)
- A Paradigm Case for the Merging of Glycal and Enzymatic Assembly Methods in Glycoconjugate Synthesis: A Highly Efficient Chemo- Enzymatic Synthesis of GM3 (I). (1997) (0)
- An Approach to the Synthesis of Bactobolin (I) and the Total Synthesis of N-Acetylactinobolamine (II): Some Remarkably Stable Hemiacetals. (1987) (0)
- The Synthesis and Evaluation of 12,13-Benzodesoxyepothilone B: A Highly Convergent Route. (1999) (0)
- Total Synthesis of the Fusarium Toxin Equisetin: Proof of the Stereochemical Relationship of the Tetramate and Terpenoid Sectors. (1990) (0)
- Synthesis of Two Useful, Enantiomerically Pure Derivatives of (S)-4-Hydroxy-2-cyclohexenone. (1990) (0)
- Synthesis of Nemorosone and Clusianone (2008) (0)
- The Total Synthesis of the Aglycon of Avermectin A1a. (1988) (0)
- Cover Picture: On the Reach of Chemical Synthesis: Creation of a Mini‐Pipeline from an Academic Laboratory (Angew. Chem. Int. Ed. 35/2010) (2010) (0)
- A Diels—Alder Route to Angularly Functionalized Bicyclic Structures. (2010) (0)
- Efficient Preparation of Intermediates Corresponding to C22-C27 and C28-C34 of FK-506. (1990) (0)
- A Remarkable Stereochemical Inversion in Some Heck Arylation Reactions. A Mechanistic Proposal. (2010) (0)
- A Concise Total Synthesis of (.+-.)-Ipalbidine by Application of the Aldimine-Diene Cyclocondensation Reaction. (1987) (0)
- The thermosetting organopolysiloxane (1992) (0)
- Total Synthesis of Cribrostatin IV (2005) (0)
- An Approach to the Synthesis of the Naphthyridinomycin Alkaloids: the Synthesis of Two Subunits. A Mannich‐Like Approach to Naphthyridinomycin. (1985) (0)
- A DIELS‐ALDER ROUTE TO CIS‐FUSED DELTA(1)‐3‐OCTALONES (1975) (0)
- Total Syntheses of Higher Monosaccharides (1987) (0)
- Total Synthesis of (.+-.)-N-Acetylneuraminic Acid. A New Strategy for the Synthesis of Glycosides of Sialic Acids (1990) (0)
- Permuting Diels—Alder and Robinson Annulation Stereopatterns. (2013) (0)
- On the Steric Course of the Reduction of 2-Alkoxy-4-pyranones: A Remarkable Demonstration of Anomeric Control. (1986) (0)
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