Samuel Waxman
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American oncologist
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Samuel Waxman's Degrees
- Masters Medicine University of Chicago
- Bachelors Chemistry University of Chicago
Why Is Samuel Waxman Influential?
(Suggest an Edit or Addition)According to Wikipedia, Samuel Waxman is the Zena and Michael A. Wiener Professor of Medicine , Distinguished Service Professor of Medicine, Hematology, and Medical Oncology, and the Distinguished Service Professor of Oncological Sciences at the Mount Sinai School of Medicine in New York City, where he has been a member of the faculty for over 30 years.
Samuel Waxman's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Mechanisms of action of arsenic trioxide. (2002) (961)
- Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): I. As2O3 exerts dose-dependent dual effects on APL cells. (1997) (772)
- Pivotal role of mTOR signaling in hepatocellular carcinoma. (2008) (675)
- Fusion between a novel Krüppel‐like zinc finger gene and the retinoic acid receptor‐alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia. (1993) (657)
- Genome‐wide molecular profiles of HCV‐induced dysplasia and hepatocellular carcinoma (2007) (645)
- Studies on treatment of acute promyelocytic leukemia with arsenic trioxide: remission induction, follow-up, and molecular monitoring in 11 newly diagnosed and 47 relapsed acute promyelocytic leukemia patients. (1999) (630)
- Focal gains of VEGFA and molecular classification of hepatocellular carcinoma. (2008) (566)
- Malignant cells can be sensitized to undergo growth inhibition and apoptosis by arsenic trioxide through modulation of the glutathione redox system. (1999) (555)
- Identification of an Immune-specific Class of Hepatocellular Carcinoma, Based on Molecular Features. (2017) (545)
- All-trans retinoic acid/As2O3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia. (2004) (542)
- Integrative molecular analysis of intrahepatic cholangiocarcinoma reveals 2 classes that have different outcomes. (2013) (418)
- Long-term efficacy and safety of all-trans retinoic acid/arsenic trioxide-based therapy in newly diagnosed acute promyelocytic leukemia (2009) (383)
- A molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosis. (2006) (381)
- Arsenic trioxide as an inducer of apoptosis and loss of PML/RAR alpha protein in acute promyelocytic leukemia cells. (1998) (373)
- Arsenic trioxide selectively induces acute promyelocytic leukemia cell apoptosis via a hydrogen peroxide-dependent pathway. (1999) (363)
- History of the development of arsenic derivatives in cancer therapy. (2001) (336)
- Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression. (2009) (320)
- Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia. (1998) (308)
- Induction of cell migration by pro-urokinase binding to its receptor: possible mechanism for signal transduction in human epithelial cells (1994) (291)
- Arsenic Trioxide Selectively Induces Acute Promyelocytic Leukemia Cell Apoptosis Via a Hydrogen Peroxide-Dependent Pathway (1999) (263)
- Apoptosis and growth inhibition in malignant lymphocytes after treatment with arsenic trioxide at clinically achievable concentrations. (1999) (251)
- Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. (2005) (245)
- Massive parallel sequencing uncovers actionable FGFR2–PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma (2015) (242)
- Gene expression networks underlying retinoic acid-induced differentiation of acute promyelocytic leukemia cells. (2000) (229)
- Deranged DNA Synthesis by Bone Marrow from Vitamin B12‐Deficient Humans * (1968) (229)
- Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia. (1993) (226)
- MicroRNA-based classification of hepatocellular carcinoma and oncogenic role of miR-517a. (2011) (223)
- Combined effect of all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia cells in vitro and in vivo. (2001) (204)
- The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor. (2008) (196)
- Leukemia translocation protein PLZF inhibits cell growth and expression of cyclin A (1999) (185)
- Amino-terminal protein-protein interaction motif (POZ-domain) is responsible for activities of the promyelocytic leukemia zinc finger-retinoic acid receptor-alpha fusion protein. (1996) (174)
- Sequence-specific DNA Binding and Transcriptional Regulation by the Promyelocytic Leukemia Zinc Finger Protein* (1997) (173)
- Differentiation therapy of acute myeloid leukemia: past, present and future. (2009) (173)
- PLZF-RAR alpha fusion proteins generated from the variant t(11;17)(q23;q21) translocation in acute promyelocytic leukemia inhibit ligand-dependent transactivation of wild-type retinoic acid receptors. (1994) (172)
- The Promyelocytic Leukemia Zinc Finger Protein Affects Myeloid Cell Growth, Differentiation, and Apoptosis (1998) (169)
- Arsenic trioxide inhibits growth of human multiple myeloma cells in the bone marrow microenvironment. (2002) (158)
- JNK activation is a mediator of arsenic trioxide-induced apoptosis in acute promyelocytic leukemia cells. (2004) (156)
- Acute promyelocytic leukemia: clinical relevance of two major PML-RAR alpha isoforms and detection of minimal residual disease by retrotranscriptase/polymerase chain reaction to predict relapse (1993) (155)
- The Histone Deacetylase 9 Gene Encodes Multiple Protein Isoforms* (2003) (150)
- Translocations of the RARα gene in acute promyelocytic leukemia (2001) (147)
- Leukemia translocation gene, PLZF, is expressed with a speckled nuclear pattern in early hematopoietic progenitors. (1995) (137)
- Clinical and Molecular Characterization of a Rare Syndrome of Acute Promyelocytic Leukemia Associated With Translocation (2002) (123)
- Boswellic acid acetate induces differentiation and apoptosis in leukemia cell lines. (1999) (120)
- Expression of the zinc-finger gene PLZF at rhombomere boundaries in the vertebrate hindbrain. (1995) (120)
- Inhibition of amino acid transport by cis-diamminedichloroplatinum(II) derivatives in L1210 murine leukemia cells. (1983) (117)
- Leukemia-associated retinoic acid receptor alpha fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies. (1997) (116)
- Clinical and cytogenetic features of 508 Chinese patients with myelodysplastic syndrome and comparison with those in Western countries (2005) (110)
- RIG-E, a human homolog of the murine Ly-6 family, is induced by retinoic acid during the differentiation of acute promyelocytic leukemia cell. (1996) (108)
- Translocations of the RARalpha gene in acute promyelocytic leukemia. (2001) (106)
- Influence on immunoreactive folate-binding proteins of extracellular folate concentration in cultured human cells. (1988) (105)
- Melanoma differentiation associated gene-7, mda-7/interleukin-24, induces apoptosis in prostate cancer cells by promoting mitochondrial dysfunction and inducing reactive oxygen species. (2003) (105)
- Unique genomic profile of fibrolamellar hepatocellular carcinoma. (2015) (104)
- Radioisotopic assay for measurement of serum folate levels. (1971) (104)
- De-regulation of common housekeeping genes in hepatocellular carcinoma (2007) (102)
- Distinct leukemia phenotypes in transgenic mice and different corepressor interactions generated by promyelocytic leukemia variant fusion genes PLZF-RARalpha and NPM-RARalpha. (1999) (101)
- Cellular retinol-binding protein expression and breast cancer. (2000) (100)
- Synergic effects of arsenic trioxide and cAMP during acute promyelocytic leukemia cell maturation subtends a novel signaling cross-talk. (2002) (98)
- Methylated metabolites of arsenic trioxide are more potent than arsenic trioxide as apoptotic but not differentiation inducers in leukemia and lymphoma cells. (2003) (96)
- Differentiation therapy. (1990) (93)
- Reduced and altered DNA-binding and transcriptional properties of the PLZF-retinoic acid receptor-alpha chimera generated in t(11;17)-associated acute promyelocytic leukemia. (1996) (91)
- The enhancement of 5-fluorouracil antimetabolic activity by leucovorin, menadione and α-tocopherol (1982) (90)
- Acute promyelocytic leukemia: clinical relevance of two major PML-RAR alpha isoforms and detection of minimal residual disease by retrotranscriptase/polymerase chain reaction to predict relapse. (1993) (89)
- Drugs, toxins and dietary amino acids affecting vitamin B12 or folic acid absorption or utilization. (1970) (88)
- Inhibition of mouse GATA-1 function by the glucocorticoid receptor: possible mechanism of steroid inhibition of erythroleukemia cell differentiation. (1993) (87)
- Poor response to all-trans retinoic acid therapy in a t(11;17) PLZF/RAR alpha patient. (1994) (86)
- Cloning of a gene (RIG-G) associated with retinoic acid-induced differentiation of acute promyelocytic leukemia cells and representing a new member of a family of interferon-stimulated genes. (1997) (81)
- Measurement of serum folate levels and serum folic acid-binding protein by 3H-PGA radioassay. (1973) (81)
- Rapid induction of cAMP/PKA pathway during retinoic acid-induced acute promyelocytic leukemia cell differentiation (2004) (80)
- Fibrolamellar carcinoma: a review with focus on genetics and comparison to other malignant primary liver tumors. (2011) (78)
- All-trans retinoic acid As 2 O 3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia (2004) (77)
- Occurrence of distinct PML-RAR-alpha fusion gene isoforms in patients with acute promyelocytic leukemia detected by reverse transcriptase/polymerase chain reaction. (1992) (76)
- Boswellic acid acetate induces apoptosis through caspase-mediated pathways in myeloid leukemia cells (2005) (76)
- Induction of reactive oxygen species renders mutant and wild-type K-ras pancreatic carcinoma cells susceptible to Ad.mda-7-induced apoptosis (2005) (75)
- Differentiation therapy in acute myelogenous leukemia (non-APL) (2000) (72)
- The cellular retinoic acid binding protein II is a positive regulator of retinoic acid signaling in breast cancer cells. (1997) (71)
- Evidence of an immunologic mechanism behind the therapeutical effects of arsenic trioxide (As(2)O(3)) on myeloma cells. (2001) (71)
- Buthionine sulfoximine enhancement of arsenic trioxide-induced apoptosis in leukemia and lymphoma cells is mediated via activation of c-Jun NH2-terminal kinase and up-regulation of death receptors. (2006) (66)
- Cyclin D1 overexpression and response to bortezomib treatment in a breast cancer model. (2006) (66)
- Retinoic acid is required for and potentiates differentiation of acute promyelocytic leukemia cells by nonretinoid agents. (1994) (66)
- Characteristics of folic acid-binding protein in folate-deficient serum. (1973) (65)
- Defective DNA synthesis in human megaloblastic bone marrow: effects of homocysteine and methionine. (1969) (62)
- Interference with Sin3 function induces epigenetic reprogramming and differentiation in breast cancer cells (2010) (62)
- Mechanism of pyrimethamine-induced megaloblastosis in human bone marrow. (1969) (61)
- Glutathione-S-transferase pi inhibits As2O3-induced apoptosis in lymphoma cells: involvement of hydrogen peroxide catabolism. (2005) (60)
- Down-regulation of Mcl-1 through GSK-3β activation contributes to arsenic trioxide-induced apoptosis in acute myeloid leukemia cells (2012) (60)
- Bexarotene Plus Erlotinib Suppress Lung Carcinogenesis Independent of KRAS Mutations in Two Clinical Trials and Transgenic Models (2011) (57)
- A tumor-related vitamin B12 binding protein in adolescent hepatoma. (1973) (55)
- Release of vitamin B12--binding protein by human leukocytes in vitro. (1970) (53)
- Role of folate binding proteins in folate metabolism. (1989) (51)
- Cell cycle gene expression and E2F transcription factor complexes in human melanoma cells induced to terminally differentiate. (1995) (51)
- Genomic sequence, structural organization, molecular evolution, and aberrant rearrangement of promyelocytic leukemia zinc finger gene. (1999) (51)
- Tamoxifen stimulates the growth of cyclin D1-overexpressing breast cancer cells by promoting the activation of signal transducer and activator of transcription 3. (2008) (49)
- Absorption and malabsorption of vitamin B 12. (1970) (49)
- FOLATE BINDING PROTEINS (1975) (49)
- LIM protein Ajuba functions as a nuclear receptor corepressor and negatively regulates retinoic acid signaling (2010) (48)
- Effect of retinoic acid isomers on proliferation, differentiation and PML relocalization in the APL cell line NB4. (1995) (48)
- Selective Inhibition of SIN3 Corepressor with Avermectins as a Novel Therapeutic Strategy in Triple-Negative Breast Cancer (2015) (47)
- Appearance of C‐type virus‐like particles after co‐cultivation of a human tumor‐cell line with rat (XC) cells (1975) (47)
- Upregulation of Bfl-1/A1 in leukemia cells undergoing differentiation by all-trans retinoic acid treatment attenuates chemotherapeutic agent-induced apoptosis (2006) (45)
- Targeted degradation of the AML1/MDS1/EVI1 oncoprotein by arsenic trioxide. (2006) (45)
- Lineage restriction of the RARα gene expression in myeloid differentiation (2001) (43)
- DNA methylation-independent loss of RARA gene expression in acute myeloid leukemia. (2008) (43)
- Dual effects of glutathione-S-transferase π on As2O3 action in prostate cancer cells: enhancement of growth inhibition and inhibition of apoptosis (2004) (42)
- Regrowth of 5-fluorouracil-treated human colon cancer cells is prevented by the combination of interferon gamma, indomethacin, and phenylbutyrate. (2000) (42)
- Retinoic acid receptor α2 is a growth suppressor epigenetically silenced in MCF-7 human breast cancer cells (2002) (41)
- Mechanism of triamterene-induced megaloblastosis. (1970) (41)
- Isolation and characterization of a novel vitamin B12-binding protein associated with hepatocellular carcinoma. (1975) (41)
- Defective expression of cellular retinol binding protein type 1 and retinoic acid receptors α2, β2, and ǵ2 in human breast cancer cells (1996) (40)
- SCHIZOPHRENIA, EPILEPSY, CANCER, METHIONINE, AND FOLATE METABOLISM PATHOGENESIS OF SCHIZOPHRENIA (1975) (40)
- The purification and characterization of the low molecular weight human folate binding protein using affinity chromatography. (1975) (40)
- Structural requirements for differentiation-induction and growth-inhibition of mouse erythroleukemia cells by isoflavones. (1995) (39)
- Combination cytotoxic-differentiation therapy of mouse erythroleukemia cells with 5-fluorouracil and hexamethylene bisacetamide. (1990) (38)
- Emerging Roles of Epigenetic Regulator Sin3 in Cancer. (2016) (38)
- Enhanced growth inhibition and differentiation of fluorodeoxyuridine-treated human colon carcinoma cells by phenylbutyrate. (1998) (38)
- Variant-type PML-RARα fusion transcript in acute promyelocytic leukemia: Use of a cryptic coding sequence from intron 2 of the RARα gene and identification of a new clinical subtype resistant to retinoic acid therapy (2002) (37)
- Arsenic Trioxide in Multiple Myeloma: Rationale and Future Directions (2002) (36)
- Advances in the management of acute promyelocytic leukemia and other hematologic malignancies with arsenic trioxide. (2002) (36)
- Combination of cytotoxic-differentiation therapy with 5-fluorouracil and phenylbutyrate in patients with advanced colorectal cancer. (2007) (36)
- Upregulation of cytokeratins 8 and 18 in human breast cancer T47D cells is retinoid-specific and retinoic acid receptor-dependent. (1996) (35)
- Cryoprotected Lactobacillus casei: an approach to standardization of microbiological assay of folic acid in serum. (1981) (35)
- Targeted removal of PML-RARalpha protein is required prior to inhibition of histone deacetylase for overcoming all-trans retinoic acid differentiation resistance in acute promyelocytic leukemia. (2002) (34)
- Sorafenib Inhibition of Mcl-1 Accelerates ATRA-Induced Apoptosis in Differentiation-Responsive AML Cells (2015) (32)
- Differentiation induction as a treatment for hematologic malignancies (2002) (32)
- Targeting the ubiquitin-proteasome pathway in cancer therapy. (2007) (32)
- Proteases stimulate mouse erythroleukemia cell differentiation and multiplication. (1982) (32)
- Interaction of chemotherapeutic agents with methotrexate and 5-fluorouracil and its effect on de novo DNA synthesis. (1975) (32)
- Ethacrynic Acid and a Derivative Enhance Apoptosis in Arsenic Trioxide–Treated Myeloid Leukemia and Lymphoma Cells: The Role of Glutathione S-Transferase P1-1 (2012) (31)
- Bortezomib Enhances the Efficacy of Fulvestrant by Amplifying the Aggregation of the Estrogen Receptor, Which Leads to a Proapoptotic Unfolded Protein Response (2011) (31)
- Differentiation therapy of cancer: laboratory and clinical investigations. (1993) (30)
- Dihydroartemisinin and its derivative induce apoptosis in acute myeloid leukemia through Noxa-mediated pathway requiring iron and endoperoxide moiety (2015) (30)
- Catabolism of 2-deoxyglucose by phagocytic leukocytes in the presence of 12-O-tetradecanoyl phorbol-13-acetate. (1978) (29)
- The status of differentiation therapy of cancer (1988) (29)
- Retinoic acid receptor alpha2 is a growth suppressor epigenetically silenced in MCF-7 human breast cancer cells. (2002) (28)
- Lineage restriction of the RARalpha gene expression in myeloid differentiation. (2001) (28)
- Targeting the SIN3A-PF1 interaction inhibits epithelial to mesenchymal transition and maintenance of a stem cell phenotype in triple negative breast cancer (2015) (27)
- Basic principles for utilizing combination differentiation agents. (1986) (27)
- Determination of folate by use of radioactive folate and binding proteins. (1980) (26)
- Establishment of a human acute promyelocytic leukemia-ascites model in SCID mice. (1996) (26)
- Targeting inhibition of K-ras enhances Ad.mda-7-induced growth suppression and apoptosis in mutant K-ras colorectal cancer cells (2007) (26)
- The isolation and characterization of the folate binding protein from goat milk (1977) (24)
- The enhancement of 5-fluorouracil anti-metabolic activity by leucovorin, menadione and alpha-tocopherol. (1982) (24)
- Randomized phase II trial of fulvestrant alone or in combination with bortezomib in hormone receptor-positive metastatic breast cancer resistant to aromatase inhibitors: a New York Cancer Consortium trial (2015) (24)
- The clinical and physiological implications of hepatoma B12-binding proteins. (1977) (24)
- The Role of Folic Acid Binding Proteins (FABP) in the Cellular Uptake of Folates 1 (1974) (23)
- State of the Translational Science (2004) (23)
- Measurement of Red Cell Folate Levels by 3H‐Pteroylglutamic Acid (3H‐PteGlu) Radioassay (1974) (22)
- Differential Binding of Folates by Rat Renal Cortex Brush Border and Basolateral Membrane Preparations (1985) (21)
- Cancer mortality in the elderly in 11 countries worldwide, 1970-2015. (2019) (21)
- Enhancement of differentiation and cytotoxicity of leukemia cells by combinations of fluorinated pyrimidines and differentiation inducers: development of DNA double-strand breaks. (1992) (21)
- Progress in differentiation induction as a treatment for acute promyelocytic leukemia and beyond. (2002) (21)
- Uptake of Tritiated Folates by Human Bone Marrow Cells in Vitro (1971) (21)
- The isolation of the folate binding protein from commercially purified bovine beta lactoglobulin (1975) (20)
- CD44 ligation with A3D8 antibody induces apoptosis in acute myeloid leukemia cells through binding to CD44s and clustering lipid rafts (2012) (20)
- DNA ligase and DNase activities in mouse erythroleukemia cells during dimethyl sulfoxide-induced differentiation. (1982) (18)
- Effects of extracellular matrix on the growth and casein gene expression of primary mouse mammary tumor cells in vitro. (1989) (18)
- Arsenic Trioxide and Sorafenib Induce Synthetic Lethality of FLT3-ITD Acute Myeloid Leukemia Cells (2018) (17)
- The Significance of Folate Binding Proteins in Folate Metabolism (1977) (17)
- Effect of intracellular folate concentration on the modulation of 5-fluorouracil cytotoxicity by the elevation of phosphoribosylpyrophosphate in cultured human KB cells. (1987) (16)
- Molecular target-based treatment of human cancer: summary of the 10th international conference on differentiation therapy. (2005) (16)
- Translocations of the RARa gene in acute promyelocytic leukemia (2001) (16)
- Clinical translation of epigenetics in cancer: eN-CORe—a report on the second workshop (2005) (16)
- A retinoid/butyric acid prodrug overcomes retinoic acid resistance in leukemias by induction of apoptosis. (2003) (16)
- EFFECTS OF DEXAMETHASONE AND PHORBOL MYRISTATE ACETATE ON THE INDUCTION OF DIFFERENTIATION IN MOUSE ERYTHROLEUKEMIC CELLS BY DIMETHYL SULFOXIDE, PROTEASES, AND OTHER COMPOUNDS * (1983) (15)
- Reduction in lactate accumulation correlates with differentiation-induced terminal cell division of leukemia cells. (1991) (15)
- The design of selective and non-selective combination therapy for acute promyelocytic leukemia. (2007) (15)
- Differentiate or Die: the View from Montreal (2000) (15)
- Abnormal Isoelectric Focusing Patterns of Serum Galactosyltransferase Activity in Patients with Liver Neoplasia (1984) (15)
- Characteristics of a Novel Serum Vitamin‐B12‐Binding Protein Associated with Hepatocellular Carcinoma (1974) (15)
- Effect of a folate-binding protein on the plasma transport and tissue distribution of folic acid. (1981) (14)
- Proteases act synergistically with low molecular weight inducers to stimulate mouse erythroleukemia cell differentiation. (1983) (14)
- Benzodithiophenes potentiate differentiation of acute promyelocytic leukemia cells by lowering the threshold for ligand-mediated corepressor/coactivator exchange with retinoic acid receptor alpha and enhancing changes in all-trans-retinoic acid-regulated gene expression. (2005) (13)
- Characterization of sialyltransferase activity from human placenta. (1978) (13)
- Alterations in glycosyltransferase levels in mouse erythroleukemia cells during erythrodifferentiation and cell growth. (1981) (13)
- Malabsorption of hemoglobin iron in pernicious anemia: correction with intrinsic factor--containing substances. (1968) (13)
- In situ hybridization of RD114-virus RNA with human metaphase chromosomes. (1973) (12)
- Glycosyltransferase alterations are cell type related when human promyelocytic leukemia (HL-60) cells are treated with various inducers of differentiation. (1983) (12)
- Inhibition of methionine transport by methotrexate in mitogen-stimulated human lymphocytes. (1983) (12)
- Myelodysplastic syndrome transforming to acute promyelocytic‐like leukemia with trisomy and rearrangement of chromosome II (1994) (12)
- Genomic structure of the human PLZF gene. (1999) (11)
- The cleavage product ΔPML–RARα contributes to all-trans retinoic acid-mediated differentiation in acute promyelocytic leukemia cells (2003) (11)
- Properties of a Homologous Series of o-Hydroxy Substituted Anils and Some Binary Mixtures (1973) (10)
- Aggravation or initiation of megaloblastosis by amino acids in the diet. (1970) (10)
- State of the Translational Science: Summary of Baltimore Workshop on Gene Re-expression As a Therapeutic Target in Cancer January 2003 (2004) (10)
- Management of asymptomatic rising PSA after prostatectomy or radiation therapy. (1997) (10)
- Cancer mortality in the oldest old: a global overview (2020) (10)
- Retinoblastoma protein and the leukemia-associated PLZF transcription factor interact to repress target gene promoters (2008) (9)
- Blocking the PAH2 domain of Sin3A inhibits tumorigenesis and confers retinoid sensitivity in triple negative breast cancer (2016) (9)
- Derepression in the desert: the third workshop on clinical translation of epigenetics in cancer therapeutics. (2008) (8)
- Human breast carcinoma slice cultures retain retinoic acid sensitivity. (1996) (8)
- Targeted interference of SIN3A-TGIF1 function by SID decoy treatment inhibits Wnt signaling and invasion in triple negative breast cancer cells. (2017) (8)
- Sequential use of methotrexate, folinic acid, and cytosine arabinoside in the treatment of acute leukemia. (1976) (8)
- Benzodithiophenes induce differentiation and apoptosis in human leukemia cells. (2005) (8)
- Selective Inhibition of SIN 3 Corepressor with Avermectins as a Novel Therapeutic Strategy in Triple-Negative Breast Cancer (2015) (8)
- Translocations of the RAR alpha gene in acute promyelocytic leukemia (2001) (7)
- Targeted interference of SIN3A-TGIF1 function by SID decoy treatment inhibits Wnt signaling and invasion in triple negative breast cancer cells (2016) (7)
- The specific release of sialyltransferase activity by human hepatoma cell lines (1979) (7)
- The 12th international conference on differentiation therapy: targeting the aberrant growth, differentiation and cell death programs of cancer cells (2011) (7)
- Characterization of galactosyltransferase released from human hepatoma cells. (1982) (7)
- The importance of the induction of gene expression and differentiation by cytotoxic chemotherapy. (1988) (7)
- Measurement of serum folate by 75Se-selenofolate radioassay. Results of a multi-institutional clinical trial. (1978) (7)
- Differentiation agents in cancer therapy. (1994) (7)
- Clinical pharmacologic effects of thymidine plus 5-FU. (1980) (7)
- Differential expression of retinoid receptors during multilineage differentiation of haemopoietic progenitor cells-role of the RAR alpha 2 isoform in normal granulopoiesis and leukaemia. (1997) (7)
- Limited effectiveness of in vitro high-dose methotrexate and leucovorin to overcome resistance in L1210 leukemia cells with elevations of dihydrofolate reductase. (1980) (7)
- ABNORMAL GLYCOPROTEINS AND GLYCOSYLTRANSFERASES IN HUMAN HEPATOMA (1980) (7)
- Protease induction of hemoglobin synthesis but not terminal cell division in K562 cells. (1985) (6)
- Antitumor drug interactions: additional data. (1976) (6)
- 12-O-tetradecanoyl-phorbol-13-acetate release of glycosyltransferases from human blood cells. (1980) (6)
- A possible effect of heme on the fate of DNA ligase activity extracted from differentiating mouse erythroleukemia cells. (1988) (5)
- Modified phosphoribosylpyrophosphate (PRPP) radioenzymatic assay: increased sensitivity, technical simplification and new applications. (1987) (5)
- Modulation of the antigenic phenotype of human breast carcinoma cells by modifiers of protein kinase C activity and recombinant human interferons (2005) (5)
- Down‐regulation of retinoic acid receptor activity associated with decreased α and γ isoforms expression in F9 embryonal carcinoma cells differentiated by retinoic acid (1993) (5)
- Invasive phenotype in triple negative breast cancer is inhibited by blocking SIN3A–PF1 interaction through KLF9 mediated repression of ITGA6 and ITGB1 (2021) (4)
- Artesunate improves venetoclax plus cytarabine AML cell targeting by regulating the Noxa/Bim/Mcl-1/p-Chk1 axis (2022) (4)
- The cleavage product deltaPML-RARalpha contributes to all-trans retinoic acid-mediated differentiation in acute promyelocytic leukemia cells. (2003) (4)
- resistance in acute promyelocytic leukemia retinoic acid differentiation trans histone deacetylase for overcoming all-protein is required prior to inhibition of α Targeted removal of PML-RAR (2002) (4)
- Phosphate-Induced Phosphoribosylpyrophosphate Elevations to Assess Deranged Folate and Purine Nucleotide Metabolism 1 (1987) (4)
- Dephosphorylation of Vav is associated with the induction of mouse erythroleukemia cell differentiation: effects of orthovanadate and levamisole. (1998) (3)
- The phosphatase inhibitors, orthovanadate and levamisole, inhibit induction of erythroid differentiation and abrogate the associated inhibition of glycolysis. (1998) (3)
- Interaction of methotrexate (mtx) and 5-fluorouracil (5fu), effect on de novo dna synthesis. Abstr. (1976) (3)
- Fludarabine phosphate selectively inhibits growth and modifies the antigenic phenotype of human glioblastoma-multiforme cells expressing a multidrug resistance phenotype. (1992) (3)
- Acute promyelocytic leukaemia associated PLZF protein interacts with the retinoblastoma tumour suppressor gene product. (1998) (3)
- Revisiting Three Mile Island. (1997) (3)
- Altered Methotrexate Sensitivity in Human Leukemic K562 Amino Acid Transport Mutant Cells (1983) (3)
- Evolutionary significance of persistence of latent oncogenic virus information in vertebrates. (1973) (3)
- Benzyl alcohol alters the hemoglobin phenotype of mouse erythroleukemia cells. (1989) (3)
- Arsenic Trioxide Plus ABT-737 Is Synergistic to Induce Apoptosis in AML Cells by Repression of Mcl-1 Protein and Inactivation of Bcl-2 Protein (2008) (2)
- Redundant regulation of urokinase plasminogen activator transcription by the two major isozymes of cAMP-dependent protein kinase. (1992) (2)
- Inhibition of methionine transport by methotrexate (mtx) in mouse leukemia l1210 cells. Abstr. (1980) (2)
- G-actin and F-actin levels at different stages of mouse erythroid differentiation. (1983) (2)
- The Leukemia cell (1979) (2)
- Meeting report: the 11th International Conference on Differentiation Therapy and Innovative Therapeutics in Oncology. (2007) (2)
- Abstract 2996: Overexpression of potential oncogenic microRNAs defines a new molecular subclass of hepatocellular carcinoma (2010) (2)
- The proportions of hemoglobin types induced in mouse erythroleukemia cells vary with the inducer or combination of inducers, the inducer concentration and the time of induction. (1985) (2)
- Role of a novel class II histone deacetylase in normal and leukemia-associated transcriptional repression. (2001) (2)
- Pyrimethamine effect on folate metabolism. (1969) (2)
- O100 DISCOVERY OF NOVEL MUTATIONS AND FUSION PROTEINS IN INTRAHEPATIC CHOLANGIOCARCINOMA (2014) (2)
- Differential binding of folate but not methotrexate by brush border and basal lateral membranes of rat renal cortex (1983) (1)
- DNA LIGASE ACTIVITY IN EXTRACTS OF MOUSE ERYTHROLEUKEMIA (MEL) CELLS DURING DIFFERENTIATION * (1982) (1)
- 1. The incorporation of Differentiation Induction into the Design of Cancer Therapy (1988) (1)
- Retinoblastoma Protein and the Leukemia-Associated PLZF Transcription Factor Interact To Repress Target Gene Promoters. (2007) (1)
- Chronic fatigue syndrome and channelopathies. (2000) (1)
- Abstract 1989: Targeting Sin3-Pf1 complex: Novel site-specific epigenetic therapy for triple negative breast cancer (2015) (1)
- 103. The retinoic acid receptor alpha (RARA) gene is fused with a transcription unit on chromosome 11q in an Acute promyelocytic leukemia (APL) patient with variant t(11;17) translocation (1992) (1)
- R esponse : Re: Apoptosis and Growth Inhibition in MalignantLymphocytes After Treatment With Arsenic Trioxide at Clinically AchievableConcentrations (1999) (1)
- The Sin3A/MAD1 Complex, through Its PAH2 Domain, Acts as a Second Repressor of Retinoic Acid Receptor Beta Expression in Breast Cancer Cells (2022) (1)
- Deregulation of RARγ and RARγ-Specific miRNAs in AML. (2007) (1)
- Folate Radioassay (contd.) (1974) (1)
- Mechanisms of Action of Arsenic Trioxide Updated (2002) (1)
- Abstract 807: Selamectin and ivermectin are small molecule inhibitors that interfere with Sin3A-PAH2 function and exert anti-tumor activity in triple-negative breast cancer (2014) (1)
- A Phase II Study of Arsenic Trioxide in the Treatment of Relapsed and Refractory Low-Grade Lymphomas (2002) (1)
- Dysregulation of hedgehog pathway signaling in hepatocellular carcinoma (2006) (1)
- Bortezomib Enhances the Efficacy of Fulvestrant by Promoting the Aggregation of the Estrogen Receptor in the Cytoplasm. (2009) (1)
- Altered membrane transport properties of l1210 cells resistant to cisplatin. Abstr. (1983) (1)
- Dithiophenes potentiate differentiation of APL cells by lowering the threshold for ligand mediated co-repressor/co-activator exchange with RAR alpha and enhancing changes in ATRA regulated gene expression. (2003) (1)
- Folate Normalizes Elevated PRPP Levels of Folate-Deficient HL-60 Cells (1986) (1)
- Abstract 2936: Molecular characterization of the immune subclass of hepatocellualr carcinoma (2017) (1)
- Deregulation of RAR gamma and RAR gamma-specific miRNAs in AML (2007) (1)
- Down-regulation of retinoic acid receptor activity associated with decreased alpha and gamma isoforms expression in F9 embryonal carcinoma cells differentiated by retinoic acid. (1993) (1)
- nuclear pattern in early hematopoietic progenitors Leukemia translocation gene, PLZF, is expressed with a speckled (2011) (1)
- Benzyl Alcohol Reduces the Accumulation of Hemoglobin Minor Compared to Hemoglobin Major in Mouse Erythroleukemia Cells Induced to Differentiate by Dimethyl Sulfoxide or Hexamethylene Bisacetamide a (1989) (1)
- The specific release of sialytransferase activity by human hepatoma cell lines. (1979) (1)
- Biotransformation of homofolate from a growth inhibitor to a growth-promoting derivative. (1983) (1)
- lymphoma cells : involvement of hydrogen peroxide catabolism-induced apoptosis in 3 O 2 inhibits As π-transferase S Glutathione (2004) (0)
- Myeloperoxidase Is Required for the Combined Apoptotic Effects of Arsenic Trioxide with Ascorbic Acid or Epigallocatechin-3-Gallate in Myeloid Leukemia Cells. (2007) (0)
- Abstract 4115: Inhibition of triple negative breast cancer cell invasion by the targeted interference of Sin3A function affecting Wnt and TGFβ signaling (2016) (0)
- 109. Differential regulation of PML-RARα and RARα1 mRNAs following trans-retinoic acid (tRA) treatment of acute promyelocytic leukemia (APL) cells (1992) (0)
- Replacing the tropolonic methoxyl group of colchicine with methylamino increases tubulin binding affinity with improved therapeutic index and overcomes paclitaxel cross-resistance. (2023) (0)
- Induction of differentiation in mouse erythroleukaemia cells by the action of papain at the cell surface (1987) (0)
- Abstract 5479: Mcl-1 is differentially regulated in acute myeloid leukemia cells treated with all trans retinoic acid and arsenic trioxide (2011) (0)
- Artesunate improves venetoclax plus cytarabine AML cell targeting by regulating the Noxa/Bim/Mcl-1/p-Chk1 axis (2022) (0)
- Differentiation or Death: The View from Versailles (1998) (0)
- Abstract P1-12-08: Bortezomib enhances the efficacy of fulvestrant by promoting the aggregation of the ER in the cytoplasm (2015) (0)
- Blocking the PAH 2 domain of Sin 3 A inhibits tumorigenesis and confers retinoid sensitivity in triple negative breast cancer (2016) (0)
- The Multiple Myeloma SET Domain (MMSET) Protein is a Histone Methyltransferase with Characteristics of a Transcriptional Co-repressor (2007) (0)
- Arsenic Trioxide Targets the MDS1 and EVI1- Containing Oncoproteins for Degradation by Proteasome Dependent and Independent Mechanisms. (2005) (0)
- The Histone Deacetylase 9 Gene Is Regulated by Multiple Promoters and Expresses Lymphoid-Specific Isoforms. (2004) (0)
- Abstract 2826: Reversal of the basal phenotype in triple negative (TN) breast cancer using a SID decoy (2011) (0)
- In vitro and in vivo growth and casein gene expression of mouse mammary tumor epithelial cells in response to hormones. (1990) (0)
- DMA Ligase and DNase Activities in Mouse Erythroleukemia Cells during Dimethyl Sulfoxide-induced Differentiation1 (2006) (0)
- Abstract 799: Diminishing Mcl-1 protein leads to apoptosis of acute myeloid leukemia cells responding to all trans retinoic acid differentiation (2014) (0)
- Abstract 411: Targeted PF1, JARID1B inhibition induces epigenetic reprogramming in triple negative breast cancer (2014) (0)
- The Status of Differentiation Therapy of Cancer—Vol II (Serona Symposia Publications—Vol. 82) (1992) (0)
- Abstract 2083: Development of novel targeted adjuvant therapy for triple negative breast cancer (2017) (0)
- Abstracts of the seventh International Conference on Differentiation Therapy, October 5-8, 1997, Versailles, France ; scientific programme (1997) (0)
- 266 Evidence of hedgehog signaling pathway activation in hepatocellular carcinoma (2006) (0)
- Cancer Therapy: Preclinical Bortezomib Enhances the Efficacy of Fulvestrant by Amplifying the Aggregation of the Estrogen Receptor, Which Leads to a Proapoptotic Unfolded Protein Response (2011) (0)
- Reactive Oxygen Species Target the Degradation of the EVI1 Oncoprotein. (2007) (0)
- Adaptative methionine transport and biosynthesis: an alternative mechanism for resistance to methotrexate (mtx) in mouse leukemia l1210 cells. Abstr. (1980) (0)
- Induction of Both CCAAT/Enhancer Binding Protein β and ε Are Required for All Trans Retinoic Acid-Induced Granulocytic Differentiation of Myeloid Leukemia Cells. (2007) (0)
- Levelling of cancer rates in the very old (2020) (0)
- Varying Effects of Deoxynucleosides on the Incorporation of Thymidine into the DNA of Monolayer and Suspension Cultures 1 (1977) (0)
- Promyelocytic Leukemia Zinc Finger Gene (2002) (0)
- Abstract 1030: Arsenic trioxide plus ethacrynic acid-butyl ester is synergistic to induce apoptosis in myeloid leukemia cells through upregulation of NOXA (2010) (0)
- Arsenic Trioxide (ATO) Downregulates the Expression of the AML1/MDS1/EVI-1 (AME) Oncoprotein and Induces Differentiation and Apoptosis in AME-Leukemic Cells. (2004) (0)
- Lack of evidence for activation of a serum factor in protease-induced differentiation of mouse erythroleukemia cells (1985) (0)
- Kinase and Up-regulation of Death Receptors-Terminal 2 Cells Is Mediated via Activation of c-Jun NH Trioxide-Induced Apoptosis in Leukemia and Lymphoma Buthionine Sulfoximine Enhancement of Arsenic (2006) (0)
- Microbial transformation of homo folate (1980) (0)
- Gene expression profiles of pre-neoplastic lesions and hepatocellular carcinoma in hepatitis C virus -cirrhotic patients (2005) (0)
- Studies on the DNA Ligase of Mouse Erythroleukemia Cells: Therapeutic Implications a (1989) (0)
- The MMSET Protein Is Tightly Associated with Chromatin, Mediates Methylation of Specific Histone Residues and Forms a Complex with a Histone Demethylase. (2006) (0)
- RAR alpha 2 isoform in normal granulopoiesis and leukemia. (1996) (0)
- methyltransferase with characteristics of a transcriptional co-repressor The Multiple Myeloma SET Domain (MMSET) protein is a histone (2013) (0)
- Effective and Selective Elimination of CML Stem Cells Using Novel Ethacrynic Acid Derivatives (2014) (0)
- Measurement of Serum Folate Levels and Blood (2005) (0)
- 114. Novel chimeric mRNA expressed in APL patient with a variant t(11;17) reciprocal chromosomal translocation between RAR-α and previously uncharacterised TFIIIA-like zinc-finger encoding gene on chromosome 1123 (1992) (0)
- Abstract LB-412: Combining bexarotene with erlotinib in window of opportunity and phase II trials causes lung cancer responses independent of KRAS mutations (2011) (0)
- Abstract #2796: Ligation of the CD44 adhesion molecule by the antibody A3D8 induces and enhances drug-induced apoptosis in acute myeloid leukemia cells through down-regulation of Mcl-1. (2009) (0)
- SITE-SPECIFIC FRAGMENT IDENTIFICATION GUIDED BY SINGLE-STEP FREE ENERGY PERTURBATION CALCULATIONS STATEMENT OF FEDERALLY SPONSORED RESEARCH AND DEVELOPMENT (2013) (0)
- 12-0-Tetradecanoyl-Phorbol-13-Acetate Release of Glycosyltransferases from Human Blood Cells (0)
- Isolation and Characterization of a Novel Vitamin B 12-Binding Protein Associated with Hepatocellular Carcinoma (2013) (0)
- Abstract 31: Targeted dissociation of PF1 from SIN3A chromatin regulator complex inhibits tumor growth and metastasis in triple-negative breast cancer (2018) (0)
- Effect of methotrexate (mtx) on l1210 leukemia in vitro as a function of mtx, leucovorin (le) and dihydrofolate reductase (dhfr). Abstr. (1976) (0)
- Abstract CN05-03: Cooperation between a rexinoid and EGFR-TKI for lung cancer prevention via Cyclin D1 destabilization (2015) (0)
- DNA Methylation Independent Silencing of the RARα Gene Expression in Acute Myeloid Leukemia. (2006) (0)
- Induction of erythroid differentiation is associated with inhibition of glycolysis and a decrease in fructose 2,6-bisphosphate levels. (1997) (0)
- Antimetabolic differences of 3 antifolates in vitro. Methotrexate (mtx), metoprine (ddmp), and baker's triazinate (bt). Abstr. (1978) (0)
- Retinoic Acid Receptor 2 Is a Growth Suppressor Epigenetically Silenced In MCF-7 Human Breast Cancer Cells 1 (2002) (0)
- Changes in g-actin and f-actin pools during mouse erythro- poiesis. Abstr. (1981) (0)
- Abstract 572: Interference with Sin3 PAH-2 domain function induces epigenetic reprogramming, differentiation and growth inhibition in breast cancer cells (2010) (0)
- Abstract 3511: Targeted epigenetic reprogramming reverts tumor progression in triple-negative breast cancer models by the activation of retinoic acid receptor alpha (2015) (0)
- Specific dithiophene analogs potentiate ATRA induction of acute promyelocytic leukemia cell differentiation and gene expression in vivo. (2002) (0)
- The GSK3β/Mcl-1 axis is regulated by both FLT3-ITD and Axl and determines the apoptosis induction abilities of FLT3-ITD inhibitors (2023) (0)
- of a transcriptional corepressor The MMSET protein is a histone methyltransferase with characteristics (2014) (0)
- Evaluation of X-methyl folate preparations as possible folic acid antagonists. (1982) (0)
- Hypermethylation of Retinoic Acid Receptor Alpha 2 (RARα2) Promoter in Human AML Cells Correlates with Poor RARα2 Expression and Response to Differentiation Inducers. (2004) (0)
- Abstract 1826: Anti-tumorigenic effects by targeted functional disruption of the Sin3 PAH-2 domain (2012) (0)
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