Santiago Schnell | Academic Influence

Santiago Schnell's AcademicInfluence.com Rankings

Santiago Schnell

Biology

#2359

World Rank

#3757

Historical Rank

Systems Biology

#41

World Rank

#41

Historical Rank

Computational Biology

#354

World Rank

#356

Historical Rank

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Biology

Santiago Schnell's Degrees

Bachelors Biology University of Carabobo
PhD Computational Biology University of California, San Diego

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Why Is Santiago Schnell Influential?

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According to Wikipedia, Santiago Schnell FRSB FRSC is a scientist and academic leader, currently serving as the William K. Warren Foundation Dean of the College of Science at the University of Notre Dame, as well as a professor in the Department of Biological Sciences, and Department of Applied and Computational Mathematics and Statistics.

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Santiago Schnell's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Reaction kinetics in intracellular environments with macromolecular crowding: simulations and rate laws. (2004) (348)
Stochastic approaches for modelling in vivo reactions (2004) (328)
Closed Form Solution for Time-dependent Enzyme Kinetics (1997) (254)
A multiscale mathematical model of cancer, and its use in analyzing irradiation therapies (2006) (217)
Enzyme kinetics at high enzyme concentration (2000) (183)
Mathematical and computational techniques to deduce complex biochemical reaction mechanisms. (2004) (170)
A Century of Enzyme Kinetics: Reliability of the K M and v v max Estimates (2003) (156)
Hedgehog-responsive mesenchymal clusters direct patterning and emergence of intestinal villi (2012) (126)
Connecting the dots: the effects of macromolecular crowding on cell physiology. (2014) (125)
A clock and wavefront mechanism for somite formation. (2006) (122)
Validity of the Michaelis–Menten equation – steady‐state or reactant stationary assumption: that is the question (2014) (116)
A systematic investigation of the rate laws valid in intracellular environments. (2006) (111)
Logic-based models in systems biology: a predictive and parameter-free network analysis method. (2012) (110)
Villification in the mouse: Bmp signals control intestinal villus patterning (2016) (105)
Multiscale modeling in biology (2007) (95)
Modelling reaction kinetics inside cells. (2008) (85)
Unraveling intestinal stem cell behavior with models of crypt dynamics. (2014) (83)
Use and abuse of the quasi-steady-state approximation. (2006) (80)
Reactant stationary approximation in enzyme kinetics. (2008) (77)
Dynamic recruitment of single RNAs to processing bodies depends on RNA functionality (2018) (76)
Circadian rhythms regulate amelogenesis. (2013) (73)
Enzymological considerations for a theoretical description of the quantitative competitive polymerase chain reaction (QC-PCR). (1997) (68)
A cell cycle model for somitogenesis: mathematical formulation and numerical simulation. (2000) (66)
Theoretical description of the polymerase chain reaction. (1997) (65)
The Circadian Clock in Oral Health and Diseases (2014) (65)
Expression of clock proteins in developing tooth. (2011) (57)
Single‐molecule enzymology à la Michaelis–Menten (2013) (57)
Novel Hybrid Phenotype Revealed in Small Cell Lung Cancer by a Transcription Factor Network Model That Can Explain Tumor Heterogeneity. (2017) (56)
Do Cellular Condensates Accelerate Biochemical Reactions? Lessons from Microdroplet Chemistry. (2018) (55)
Enzyme kinetics far from the standard quasi-steady-state and equilibrium approximations (2002) (54)
The condition for pseudo-first-order kinetics in enzymatic reactions is independent of the initial enzyme concentration. (2003) (51)
On the estimation errors of KM and V from time-course experiments using the Michaelis-Menten equation. (2016) (51)
Mathematical models for somite formation. (2008) (50)
Reconstructing biochemical pathways from time course data (2007) (50)
A mathematical investigation of a Clock and Wavefront model for somitogenesis (2006) (45)
Time-dependent closed form solutions for fully competitive enzyme reactions (2000) (45)
The mechanism distinguishability problem in biochemical kinetics: the single-enzyme, single-substrate reaction as a case study. (2006) (44)
Coordinated action of N-CAM, N-cadherin, EphA4, and ephrinB2 translates genetic prepatterns into structure during somitogenesis in chick. (2008) (41)
Enzyme kinetics of multiple alternative substrates (2000) (40)
Follow-the-leader cell migration requires biased cell–cell contact and local microenvironmental signals (2013) (40)
The importance of accurately correcting for the natural abundance of stable isotopes. (2017) (39)
Molecular and circadian controls of ameloblasts. (2011) (39)
Waves and patterning in developmental biology: vertebrate segmentation and feather bud formation as case studies. (2009) (38)
From segment to somite: Segmentation to epithelialization analyzed within quantitative frameworks (2007) (38)
Estimation of the lag time in a subsequent monomer addition model for fibril elongation. (2016) (37)
Should digestion assays be used to estimate persistence of potential allergens in tests for safety of novel food proteins? (2009) (37)
Systems biologists seek fuller integration of systems biology approaches in new cancer research programs. (2010) (37)
Models for pattern formation in somitogenesis: a marriage of cellular and molecular biology. (2002) (32)
Can tissue surface tension drive somite formation? (2007) (32)
Gonadotropin-Releasing Hormone (GnRH) Neuron Excitability Is Regulated by Estradiol Feedback and Kisspeptin (2017) (31)
Network motifs provide signatures that characterize metabolism. (2013) (31)
Coordination of signaling and tissue mechanics during morphogenesis of murine intestinal villi: a role for mitotic cell rounding. (2016) (31)
Ten Simple Rules for a Computational Biologist’s Laboratory Notebook (2015) (29)
Why substrate depletion has apparent first-order kinetics in enzymatic digestion (2006) (29)
Computational modelling of cell chain migration reveals mechanisms that sustain follow-the-leader behaviour (2012) (29)
STRENDA DB: enabling the validation and sharing of enzyme kinetics data (2018) (28)
Correction: Novel Hybrid Phenotype Revealed in Small Cell Lung Cancer by a Transcription Factor Network Model That Can Explain Tumor Heterogeneity. (2017) (27)
RhoC GTPase Is a Potent Regulator of Glutamine Metabolism and N-Acetylaspartate Production in Inflammatory Breast Cancer Cells* (2016) (25)
Loss of the Ubiquitin-conjugating Enzyme UBE2W Results in Susceptibility to Early Postnatal Lethality and Defects in Skin, Immune, and Male Reproductive Systems* (2015) (24)
How reaction kinetics with time-dependent rate coefficients differs from generalized mass action. (2006) (23)
A Model of the Unfolded Protein Response: Pancreatic β-Cell as a Case Study (2009) (23)
New approaches to modelling and analysis of biochemical reactions, pathways and networks. (2004) (22)
Globalization and changing trends of biomedical research output. (2017) (22)
Is the intrinsic disorder of proteins the cause of the scale‐free architecture of protein–protein interaction networks? (2006) (22)
Multiscale modeling of developmental systems (2008) (22)
A test for measuring the effects of enzyme inactivation. (2007) (22)
Network representations and methods for the analysis of chemical and biochemical pathways. (2013) (22)
On the origin of non-membrane-bound organelles, and their physiological function. (2017) (21)
The Quasi-State-State Approximations revisited: Timescales, small parameters, singularities, and normal forms in enzyme kinetics. (2019) (21)
Approaches for the estimation of timescales in nonlinear dynamical systems: Timescale separation in enzyme kinetics as a case study. (2017) (20)
Formation of Vertebral Precursors: Past Models and Future Predictions (2003) (20)
The effects of time delays in a phosphorylation-dephosphorylation pathway. (2007) (20)
Extracting Biochemical Reaction Kinetics from Time Series Data (2004) (19)
Stability of open pathways. (2010) (19)
A mathematical formulation for the cell-cycle model in somitogenesis: analysis, parameter constraints and numerical solutions. (2004) (19)
Unraveling the contribution of pancreatic beta-cell suicide in autoimmune type 1 diabetes. (2015) (19)
Multiscale Modeling in Biology New insights into cancer illustrate how mathematical tools are enhancing the understanding of life from the smallest scale to the grandest (19)
Development, growth and maintenance of β-cell mass: models are also part of the story. (2015) (18)
Characteristic, completion or matching timescales? An analysis of temporary boundaries in enzyme kinetics. (2018) (18)
Integration of Steady-State and Temporal Gene Expression Data for the Inference of Gene Regulatory Networks (2013) (18)
Modeling the World (2005) (18)
Radial WNT5A-Guided Post-mitotic Filopodial Pathfinding Is Critical for Midgut Tube Elongation. (2018) (17)
A collection of intrinsic disorder characterizations from eukaryotic proteomes (2016) (16)
Unravelling the impact of obstacles in diffusion and kinetics of an enzyme catalysed reaction. (2014) (16)
On the validity and errors of the pseudo-first-order kinetics in ligand-receptor binding. (2017) (16)
On the estimation errors of KM and V from time-course experiments using the Michaelis–Menten equation (2016) (16)
A Mesoscopic Simulation Approach for Modeling Intracellular Reactions (2007) (16)
How can mathematics help us explore vertebrate segmentation? (2009) (16)
“Reproducible” Research in Mathematical Sciences Requires Changes in our Peer Review Culture and Modernization of our Current Publication Approach (2018) (15)
An empirical analysis of enzyme function reporting for experimental reproducibility: Missing/incomplete information in published papers. (2018) (15)
Inferring the Effects of Honokiol on the Notch Signaling Pathway in SW480 Colon Cancer Cells (2014) (14)
A Kinetic Analysis of Coupled (or Auxiliary) Enzyme Reactions (2018) (13)
A theory of reactant-stationary kinetics for a mechanism of zymogen activation. (2018) (13)
Distributions-per-Level: A Means of Testing Level Detectors and Models of Patch-Clamp Data (2003) (13)
A century of enzyme kinetics. Should we believe in the Km and vmax estimates (2003) (13)
Unraveling the nature of the segmentation clock: Intrinsic disorder of clock proteins and their interaction map (2006) (12)
Interpreting SARS-CoV-2 seroprevalence, deaths, and fatality rate — Making a case for standardized reporting to improve communication (2021) (12)
Changes in Both Neuron Intrinsic Properties and Neurotransmission Are Needed to Drive the Increase in GnRH Neuron Firing Rate during Estradiol-Positive Feedback (2019) (11)
SPATIOTEMPORAL PATTERN FORMATION IN EARLY DEVELOPMENT: A REVIEW OF PRIMITIVE STREAK FORMATION AND SOMITOGENESIS (2001) (11)
A Fast Method to Estimate Kinetic Constants for Enzyme Inhibitors (2001) (11)
A model of threshold behavior reveals rescue mechanisms of bystander proteins in conformational diseases. (2011) (11)
A multiscale mathematical model of cancer growth and radiotherapy eﬃcacy : The role of cel l cycle regulation in response to irradiation (2006) (11)
Quantitative proteome-based guidelines for intrinsic disorder characterization. (2016) (10)
Enzyme catalyzed reactions: From experiment to computational mechanism reconstruction (2010) (10)
The intranuclear environment. (2008) (10)
Phase-plane geometries in coupled enzyme assays. (2018) (9)
Predicting neuroblastoma using developmental signals and a logic-based model. (2018) (9)
Unraveling the complex regulatory relationships between metabolism and signal transduction in cancer. (2012) (9)
Expression of sodium channels with different saxitoxin affinity during rat forebrain development. (1994) (9)
Limit cycles in the presence of convection: a traveling wave analysis. (2007) (8)
On the quasi-steady-state approximation in an open Michaelis–Menten reaction mechanism (2021) (7)
A Graphical User Interface for a Method to Infer Kinetics and Network Architecture (MIKANA) (2011) (7)
Autoantibodies Directed Toward a Novel IA-2 Variant Protein Enhance Prediction of Type 1 Diabetes (2019) (7)
On the Need to Develop Guidelines for Characterizing and Reporting Intrinsic Disorder in Proteins (2019) (7)
Macroscopic simulations of microtubule dynamics predict two steady-state processes governing array morphology (2011) (7)
Trends in NIH-supported career development funding: implications for institutions, trainees, and the future research workforce (2020) (7)
Turing pattern outside of the Turing domain (2007) (6)
Multiscale modeling of developmental systems. Introduction. (2008) (6)
Enhancing career development of postdoctoral trainees: act locally and beyond (2019) (6)
84.20 A formula for integrating inverse functions (2000) (6)
Information processing by endoplasmic reticulum stress sensors (2019) (5)
Mapping protein-protein interactions in homodimeric CYP102A1 by crosslinking and mass spectrometry. (2021) (5)
EnzymeML—a data exchange format for biocatalysis and enzymology (2021) (5)
Disorder Atlas: web-based software for the proteome-based interpretation of intrinsic disorder predictions (2016) (5)
Estimation of the lag time in a subsequent monomer addition model for fibril elongation (2016) (5)
Clathrin Heavy Chain Knockdown Impacts CXCR4 Signaling and Post-translational Modification (2019) (5)
Competitive inhibition reaction mechanisms for the two-step model of protein aggregation. (2014) (4)
Surveying the floodgates: estimating protein flux into the endoplasmic reticulum lumen in Saccharomyces cerevisiae (2014) (4)
Formation of monocarboxylic acids and polyols on a graphite surface (2008) (4)
Metabolic network motifs can provide novel insights into evolution: The evolutionary origin of Eukaryotic organelles as a case study (2014) (4)
Bulletin of mathematical biology—facts, figures and comparisons (2004) (3)
Rethinking Models of Pattern Formation in Somitogenesis. (2015) (3)
Optimal Experimental Design to Estimate Statistically Significant Periods of Oscillations in Time Course Data (2014) (3)
Molecular aspects of pancreatic beta cell failure and diabetes. (2015) (3)
A computational approach to studying ageing at the individual level (2016) (3)
How to design an optimal sensor network for the unfolded protein response (2018) (3)
Computational Modeling of Genetic and Biochemical Networks.Edited by James M. Bower and Hamid BolouriComputational Molecular Biology, A Bradford Book, The MIT Press, Cambridge, Massachusetts; 2004;ISBN: 0 262 52423 6; Paperback; 390pp.;£22.95/$35.00. (2006) (2)
Are the biomedical sciences ready for synthetic biology? (2020) (2)
β-arrestin mediates communication between plasma membrane and intracellular GPCRs to regulate signaling (2020) (2)
Hunting ε: The Origin and Validity of Quasi-Steady-State Reductions in Enzyme Kinetics (2021) (2)
On the anti-quasi-steady-state conditions of enzyme kinetics. (2021) (2)
Inferring Intracellular Signal Transduction Circuitry from Molecular Perturbation Experiments (2017) (2)
A mathematical basis for the clock and wavefront model for somitogenesis (2007) (2)
A quantitative description of the competitive polymerase chain reaction (1996) (2)
Theory of the reactant-stationary kinetics for a coupled enzyme assay (2018) (2)
A transcription factor network model explains heterogeneity and reveals a novel hybrid phenotype in Small-Cell Lung Cancer . Authors / Affiliations (2016) (2)
Stochastic enzyme kinetics and the quasi-steady-state reductions: Application of the slow scale linear noise approximation à la Fenichel (2021) (2)
Explaining inter-lab variance in C. elegans N2 lifespan: Making a case for standardized reporting to enhance reproducibility (2021) (2)
On the validity and errors of the pseudo-first-order kinetics in ligand–receptor binding (2016) (2)
Systems biologists hope for a full integration of their field into cancer research. (2010) (1)
Effects of Protein Quality Control Machinery on Protein Homeostasis (2011) (1)
7 Coordinated Action of N-CAM , N-cadherin , EphA 4 , and ephrinB 2 Translates Genetic (2007) (1)
The embryonic trunk neural crest microenvironment regulates the plasticity and invasion of human neuroblastoma via TrkB signaling. (2021) (1)
The Nature of Information (2005) (1)
A Kinetic Analysis of Coupled (or Auxiliary) Enzyme Reactions (2018) (1)
Theory of the reactant-stationary kinetics for a coupled auxiliary enzyme assay (2018) (1)
6 Models for Somite Formation (2008) (1)
Concentration Sensing in Crowded Environments. (2021) (1)
The Art of Mathematical Biology: a Foreword for the Launch of BIOMATH (2012) (1)
The human disease gene CLEC16A encodes an intrinsically disordered protein region required for mitochondrial quality control (2021) (1)
A kinetic analysis of coupled sequential enzyme reactions (2018) (1)
On the Validity of the Stochastic Quasi-Steady-State Approximation in Open Enzyme Catalyzed Reactions: Timescale Separation or Singular Perturbation? (2021) (1)
Are the biomedical sciences ready for synthetic biology? (2020) (1)
Interpreting Sars-Cov-2 Fatality Rate Estimates — A Case for Introducing Standardized Reporting to Improve Communication (2020) (1)
A Mesoscopic Simulation Approach for Modeling (2007) (1)
More than Skew: Asymmetric Wave Propagation in a Reaction-Diffusion-Convection System. (2013) (1)
Evidence for Residual and Partly Reparable Insulin Secretory Function and Maintained β-Cell Gene Expression in Islets From Patients With Type 1 Diabetes (2015) (1)
6 Mathematical Models for Somite Formation (2007) (0)
Concentration Sensing in Crowded Environments (2020) (0)
Abstract 20311: MYBPC3 Mutations Causative for Hypertrophic Cardiomyopathy Result in Locus-Dependent Alterations in Cellular Localization and Contractility (2014) (0)
Computational Cell Biology (2003) (0)
A TWO-STEP KINETIC MODEL OF INSULIN AGGREGATION WITH A COMPETITIVE INHIBITOR (2014) (0)
Abstract 1203: Metastasis-associated oncogene RhoC as a regulator of glutamine metabolism in the inflammatory breast cancer cell line SUM149 (2015) (0)
IN20 FROM SINGLE CELL MOTILITY TO SIGNALLING AND METABOLIC INTEGRATION: HOW MATHEMATICAL AND PHYSICAL MODELS CAN HELP CONTROL METASTASES IN PERSONALIZED MEDICINE (2013) (0)
Protein Interactions and Transition Times that Influence the Pathogenesis of Protein Folding Diseases (2014) (0)
Theory of the reactant-stationary kinetics for zymogen activation coupled to an enzyme catalyzed reaction (2018) (0)
Natural Parameter Conditions for Singular Perturbations of Chemical and Biochemical Reaction Networks (2022) (0)
Tyrosine phosphorylation is critical for ACLY activity in lipid metabolism and cancer (2020) (0)
Information Processing by ER Stress Sensors (2019) (0)
Manuscript Title: Concentration Sensing in Crowded Environments (2020) (0)
Tyrosine phosphorylation of ACLY regulates lipid metabolism and oncogenesis in ALK positive Anaplastic Large Cell Lymphoma (2020) (0)
Varing chemical equilibrium gives kinetic parameters (2013) (0)
Erratum to “Enzyme Kinetics Far from the Standard Quasi-Steady-State and Equilibrium Approximations” (2002) (0)
Supplementary material from "Information processing by endoplasmic reticulum stress sensors" (2019) (0)
WITHDRAWN: A mathematical basis for the clock and wavefront model for somitogenesis (2007) (0)
Applying the quasi-steady-state approximation to the autocatalytic zymogen activation: A novel general methodology for scaling analysis (2020) (0)
Book review (2004) (0)
Supplementary Information : Network motifs provide signatures that characterize metabolism (2012) (0)
Inferring Intracellular Signal Transduction Circuitry from Molecular Perturbation Experiments (2017) (0)
Quantitative proteome-based guidelines for intrinsic disorder characterization (2015) (0)
Abstract 5239: Unraveling the complex regulatory relationship between PI3K signaling and metabolic transformation in breast cancer. (2013) (0)
806 Notch Pathway Regulation of Intestinal Stem Cell Self-Renewal (2016) (0)
Firing patterns of gonadotropin-releasing hormone neurons are sculpted by their biologic state (2020) (0)
Effects of Crowding Agents and Volume Exclusion on Amyloid Beta Fibrillation (2015) (0)
Knitting Proteins (2020) (0)
The Quasi-Steady-State Approximations revisited: Timescales, small parameters, singularities, and normal forms in enzyme kinetic. (2019) (0)
Abstract 5223: Elucidating the complex cross-talk between the MAPK and PIK3 pathways. (2013) (0)
Abstract 357: A systems biology approach for rational molecular network inference (2014) (0)
Unravelling the function and kinetics of biochemical networks (2006) (0)
The standard, reverse and total Quasi-Steady-State Approximations revised: Timescale, small parameters, normal forms and singularities in enzyme kinetics (2019) (0)
Steady-State Kinetics of the Autocatalytic Zymogen Activation: A Comparison with the Michaelis-Menten Reaction Mechanism (2019) (0)
“Reproducible” Research in Mathematical Sciences Requires Changes in our Peer Review Culture and Modernization of our Current Publication Approach (2018) (0)
Assumptions of biological measurements: important considerations when evaluating western blot data (2021) (0)
Philip K. Maini's 60th Birthday Meeting (2020) (0)
EffEcts Of thE circADiAn clOcK in sAlivArY glAnDs AnD sAlivA flOW (2013) (0)
Front Cover: On the Need to Develop Guidelines for Characterizing and Reporting Intrinsic Disorder in Proteins (2019) (0)
Dynamic Recruitment of S ingle RNAs to Processing Bodies Depends on RNA Functionality Graphical (2019) (0)
Designing nanoparticle treatment of autoimmunity with quantitative biology (2013) (0)
Clathrin heavy chain knockdown impacts CXCR 4 signaling and steady-state protein expression (0)
Parametric sensitivity in chemical systems by Arvind Varma, Massimo Morbidelli and Hua Wu, 1999. Cambridge series in chemical engineering, Cambridge University Press. £60.00/$90.00, ISBN: 0-521-62171-2 (2004) (0)

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