Sarah Delaney
Professor of Chemistry at Brown University
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Chemistry
Sarah Delaney's Degrees
- PhD Chemistry Stanford University
Why Is Sarah Delaney Influential?
(Suggest an Edit or Addition)According to Wikipedia, Sarah Delaney is an American chemist who is a professor and Associate Dean of Academic Affairs at Brown University. Her research investigates DNA damage and how it is related to human disease. Early life and education Delaney was an undergraduate student at Middlebury College, where she majored in chemistry, researching cisplatin anti-cancer analogs. She moved to the California Institute of Technology for graduate research, where she worked alongside Jacqueline Barton on the role of DNA in charge-transfer reactions. In particular, she investigated whether the helical stack of base pairs in the double helix impact charge transport.
Sarah Delaney's Published Works
Published Works
- Reduction and Anticancer Activity of Platinum(IV) Complexes (1998) (210)
- Oxidative damage by ruthenium complexes containing the dipyridophenazine ligand or its derivatives: a focus on intercalation. (2002) (186)
- Long-range DNA charge transport. (2003) (163)
- Chemical and biological consequences of oxidatively damaged guanine in DNA (2012) (91)
- A Chemical and Kinetic Perspective on Base Excision Repair of DNA (2014) (72)
- Charge transport in DNA duplex/quadruplex conjugates. (2003) (71)
- Structure-dependent DNA damage and repair in a trinucleotide repeat sequence. (2009) (70)
- DNA Polymerase V Allows Bypass of Toxic Guanine Oxidation Products in Vivo* (2007) (63)
- The substrate specificity of MutY for hyperoxidized guanine lesions in vivo. (2007) (49)
- Incidence and persistence of 8-oxo-7,8-dihydroguanine within a hairpin intermediate exacerbates a toxic oxidation cycle associated with trinucleotide repeat expansion. (2011) (47)
- Transient-state kinetics of apurinic/apyrimidinic (AP) endonuclease 1 acting on an authentic AP site and commonly used substrate analogs: the effect of diverse metal ions and base mismatches. (2013) (36)
- Differential Ability of Five DNA Glycosylases to Recognize and Repair Damage on Nucleosomal DNA. (2017) (34)
- Charge equilibration between two distinct sites in double helical DNA. (2004) (33)
- Substitution and Reduction of Platinum(IV) Complexes by a Nucleotide, Guanosine 5'-Monophosphate. (1999) (33)
- A platinum(IV) complex oxidizes guanine to 8-oxo-guanine in DNA and RNA. (2001) (32)
- AGG interruptions in (CGG)(n) DNA repeat tracts modulate the structure and thermodynamics of non-B conformations in vitro. (2010) (31)
- Rapid radical formation by DNA charge transport through sequences lacking intervening guanines. (2003) (28)
- Human Oxoguanine Glycosylase 1 Removes Solution Accessible 8-Oxo-7,8-dihydroguanine Lesions from Globally Substituted Nucleosomes Except in the Dyad Region. (2018) (26)
- Chemical-biological fingerprinting: probing the properties of DNA lesions formed by peroxynitrite. (2007) (26)
- Trinucleotide repeat DNA alters structure to minimize the thermodynamic impact of 8-oxo-7,8-dihydroguanine. (2012) (26)
- Structure of even/odd trinucleotide repeat sequences modulates persistence of non-B conformations and conversion to duplex. (2011) (25)
- A Comparison of Methods for the Extraction of Plasmids Capable of Conferring Antibiotic Resistance in a Human Pathogen From Complex Broiler Cecal Samples (2018) (22)
- CAG/CTG repeats alter the affinity for the histone core and the positioning of DNA in the nucleosome. (2012) (22)
- Human OGG1 activity in nucleosomes is facilitated by transient unwrapping of DNA and is influenced by the local histone environment. (2017) (22)
- Mechanistic Studies of Hairpin to Duplex Conversion for Trinucleotide Repeat Sequences* (2010) (18)
- Initiating base excision repair in chromatin. (2018) (16)
- The global repair profile of human alkyladenine DNA glycosylase on nucleosomes reveals DNA packaging effects. (2019) (16)
- Nucleosomes and the three glycosylases: High, medium, and low levels of excision by the uracil DNA glycosylase superfamily. (2018) (15)
- AGG/CCT interruptions affect nucleosome formation and positioning of healthy-length CGG/CCG triplet repeats (2013) (14)
- Unique Length-Dependent Biophysical Properties of Repetitive DNA. (2016) (12)
- Histone H2A Variants Enhance the Initiation of Base Excision Repair in Nucleosomes. (2019) (11)
- Thermodynamic consequences of the hyperoxidized guanine lesion guanidinohydantoin in duplex DNA. (2012) (11)
- Chromatin and other obstacles to base excision repair: potential roles in carcinogenesis. (2019) (10)
- Development of a DNA-damaging ferrocene amino acid (2011) (10)
- 16S rRNA gene based bacterial community structure of wastewater treatment plant effluents (2019) (10)
- Rate-determining Step of Flap Endonuclease 1 (FEN1) Reflects a Kinetic Bias against Long Flaps and Trinucleotide Repeat Sequences* (2015) (9)
- A small unstructured nucleic acid disrupts a trinucleotide repeat hairpin. (2011) (8)
- Klenow Fragment Discriminates against the Incorporation of the Hyperoxidized dGTP Lesion Spiroiminodihydantoin into DNA. (2015) (7)
- Challenges for base excision repair enzymes: Acquiring access to damaged DNA in chromatin. (2019) (6)
- Comparison of the Base Excision and Direct Reversal Repair Pathways for Correcting 1,N6-Ethenoadenine in Strongly Positioned Nucleosome Core Particles (2020) (6)
- Premutation huntingtin allele adopts a non-B conformation and contains a hot spot for DNA damage. (2011) (3)
- Obstacles and opportunities for base excision repair in chromatin. (2022) (3)
- Nucleosome Core Particles Lacking H2B or H3 Tails Are Altered Structurally and Have Differential Base Excision Repair Fingerprints. (2021) (2)
- Oxidative DNA Damage by Long-Range Charge Transport (2004) (2)
- More than what we eat: Investigating an alternative pathway for intact starch granules in dental calculus using Experimental Archaeology (2022) (2)
- 1,N6-Ethenoadenine: From Molecular to Biological Consequences†. (2020) (2)
- Histone variants H3.3 and H2A.Z/H3.3 facilitate excision of uracil from nucleosome core particles. (2022) (2)
- The Domino Effect: Nucleosome Dynamics and the Regulation of Base Excision Repair Enzymes (2022) (1)
- 115 The rate of hOGG1-mediated 8-oxoG removal from nucleosomal DNA (2013) (1)
- Investigation into the effect of mannan-rich fraction supplementation on the metagenome of broiler chickens (2021) (1)
- Microbiome and resistome of the gastrointestinal tract of broiler chickens (2019) (1)
- The Importance of Intercalation in Long-range Guanine Oxidation in DNA Duplexes. (2001) (0)
- 79 Thermodynamic and kinetic studies of trinucleotide repeat (TNR) DNA (2013) (0)
- 105 Activity of DNA ligase on substrates containing non-canonical structures (2013) (0)
- 122 Kinetics of apurinic/apyrimidinic endonuclease 1 (APE1) on an authentic AP site or an AP site analog (2013) (0)
- The Trouble with Triples: Elucidating the Behavior of Trinucleotide Repeats in Chromatin (2013) (0)
- Transposon-Aided Capture of Antibiotic Resistance Plasmids from Complex Samples. (2019) (0)
- 109 The road to genome expansion is paved with good intentions: when DNA repair goes awry (2015) (0)
- Long‐Range DNA Charge Transport. (2003) (0)
- Investigation of Trinucleotide Repeat Structure in Nucleosome Core Particles (2011) (0)
- Ionic strength modulates excision of uracil by SMUG1 from nucleosome core particles. (2023) (0)
- 58 Packaging trinucleotide repeats: the effect of CAG/CTG repeats on nucleosome formation (2013) (0)
- Kinetic Analysis of the Effect of N-Terminal Acetylation on Thymine DNA Glycosylase. (2022) (0)
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