Sarah Spiegel

Q: What Schools Are Affiliated With Sarah Spiegel

Sarah Spiegel is affiliated with the following schools: Niigata University, Virginia Commonwealth University, Pennsylvania State University, Stanford University, University System of Maryland, Georgetown University, Yokohama City University, University of Connecticut, Thomas Jefferson University, Uniformed Services University of the Health Sciences

Sarah Spiegel's AcademicInfluence.com Rankings

Sarah Spiegel

Biology

#4638

World Rank

#6895

Historical Rank

Biochemistry

#487

World Rank

#571

Historical Rank

biology Degrees

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Biology

Sarah Spiegel's Degrees

PhD Biology Stanford University

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Sarah Spiegel's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Sphingosine-1-phosphate: an enigmatic signalling lipid (2003) (2053)
Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate (1996) (1485)
Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. (2000) (1180)
Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1. (1998) (1014)
Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens (1993) (882)
Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate (2009) (881)
Sphingosine-1-phosphate signaling and its role in disease. (2012) (870)
Sphingolipid metabolites in inflammatory disease (2014) (855)
The outs and the ins of sphingosine-1-phosphate in immunity (2011) (723)
Essential Role for Sphingosine Kinases in Neural and Vascular Development (2005) (721)
SPHINGOSINE-1-PHOSPHATE: A MISSING COFACTOR FOR THE E3 UBIQUITIN LIGASE TRAF2 (2010) (691)
Sphingolipid metabolism and cell growth regulation (1996) (687)
“Inside-Out” Signaling of Sphingosine-1-Phosphate: Therapeutic Targets (2008) (682)
Molecular Cloning and Functional Characterization of a Novel Mammalian Sphingosine Kinase Type 2 Isoform* (2000) (659)
Sphingolipids--the enigmatic lipid class: biochemistry, physiology, and pathophysiology. (1997) (643)
Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation (1991) (605)
Sphingosine 1-Phosphate, a Key Cell Signaling Molecule* (2002) (584)
SphK1 and SphK2, Sphingosine Kinase Isoenzymes with Opposing Functions in Sphingolipid Metabolism* (2005) (577)
Sphingosine kinase, sphingosine-1-phosphate, and apoptosis. (2002) (544)
Molecular Cloning and Functional Characterization of Murine Sphingosine Kinase* (1998) (544)
Sphingosine Kinase Expression Increases Intracellular Sphingosine-1-Phosphate and Promotes Cell Growth and Survival (1999) (542)
Dual Actions of Sphingosine-1-Phosphate: Extracellular through the Gi-coupled Receptor Edg-1 and Intracellular to Regulate Proliferation and Survival (1998) (487)
Signal transduction through lipid second messengers. (1996) (482)
Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases. (2006) (473)
Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer. (2013) (466)
Role of the Sphingosine-1-Phosphate Receptor EDG-1 in PDGF-Induced Cell Motility (2001) (442)
Mice Deficient in Sphingosine Kinase 1 Are Rendered Lymphopenic by FTY720* (2004) (440)
Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling (2005) (431)
Role of ABCC1 in export of sphingosine-1-phosphate from mast cells (2006) (421)
Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond (2013) (384)
Sphingosine Kinase Type 2 Is a Putative BH3-only Protein That Induces Apoptosis* (2003) (358)
Sphingosine 1-Phosphate Stimulates Cell Migration through a Gi-coupled Cell Surface Receptor (1999) (355)
Sphingolipid signalling in Arabidopsis guard cells involves heterotrimeric G proteins (2003) (349)
Transactivation of Sphingosine-1–Phosphate Receptors by FcɛRI Triggering Is Required for Normal Mast Cell Degranulation and Chemotaxis (2004) (346)
Apoptosis induces expression of sphingosine kinase 1 to release sphingosine‐1‐phosphate as a “come‐and‐get‐me” signal (2008) (330)
Extracellular and intracellular actions of sphingosine-1-phosphate. (2010) (327)
Sphingosine 1‐phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma (2001) (321)
International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid Receptor Nomenclature (2010) (319)
Sphingosine‐1‐phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration (2011) (312)
Ceramide Kinase, a Novel Lipid Kinase (2002) (301)
Autocrine and paracrine roles of sphingosine-1-phosphate (2007) (296)
Targeting SphK1 as a new strategy against cancer. (2008) (293)
The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2 (2003) (293)
Sphingosine‐1‐phosphate: signaling inside and out (2000) (286)
Sphingosine 1-Phosphate Inhibits Activation of Caspases that Cleave Poly(ADP-ribose) Polymerase and Lamins during Fas- and Ceramide-mediated Apoptosis in Jurkat T Lymphocytes* (1998) (280)
Involvement of Sphingosine 1-Phosphate in Nerve Growth Factor-Mediated Neuronal Survival and Differentiation (1997) (277)
Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway. (1994) (266)
Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis. (2012) (262)
Lysophospholipid receptor nomenclature review: IUPHAR Review 8 (2014) (261)
Sphingoid base 1-phosphate phosphatase: a key regulator of sphingolipid metabolism and stress response. (1998) (250)
Estradiol Induces Export of Sphingosine 1-Phosphate from Breast Cancer Cells via ABCC1 and ABCG2* (2010) (249)
A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia. (2008) (240)
Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells. (2002) (234)
N,N-Dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: modulation of cellular levels of sphingosine 1-phosphate and ceramide. (1998) (233)
Conjugated bile acids activate the sphingosine‐1‐phosphate receptor 2 in primary rodent hepatocytes (2012) (228)
A GTPase-independent Mechanism of p21-activated Kinase Activation (1998) (220)
Purification and Characterization of Rat Kidney Sphingosine Kinase* (1998) (218)
Ceramide Kinase Mediates Cytokine- and Calcium Ionophore-induced Arachidonic Acid Release* (2003) (212)
Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species. (2005) (212)
Sphingosine‐1‐Phosphate in Cell Growth and Cell Death a (1998) (210)
Sphingosine‐1‐phosphate: dual messenger functions (2002) (208)
Sphingosine kinase 1 is required for migration, proliferation and survival of MCF‐7 human breast cancer cells (2005) (207)
Functions of a new family of sphingosine-1-phosphate receptors. (2000) (203)
Sphingosine stimulates cellular proliferation via a protein kinase C-independent pathway. (1990) (202)
Functions of the Multifaceted Family of Sphingosine Kinases and Some Close Relatives* (2007) (199)
Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells (2001) (194)
Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death. (2000) (193)
Revisiting the sphingolipid rheostat: Evolving concepts in cancer therapy. (2015) (192)
Generation and metabolism of bioactive sphingosine‐1‐phosphate (2004) (191)
Sphingosine 1‐phosphate: a prototype of a new class of second messengers (1999) (189)
Ligand-induced trafficking of the sphingosine-1-phosphate receptor EDG-1. (1999) (189)
Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6. (2000) (188)
Enzymatic measurement of sphingosine 1-phosphate. (1999) (187)
Involvement of Sphingosine in Mitochondria-dependent Fas-induced Apoptosis of Type II Jurkat T Cells* (2000) (184)
A novel acylglycerol kinase that produces lysophosphatidic acid modulates cross talk with EGFR in prostate cancer cells (2005) (182)
Export and functions of sphingosine-1-phosphate. (2009) (181)
Sphingosine 1-Phosphate-induced Cell Rounding and Neurite Retraction Are Mediated by the G Protein-coupled Receptor H218* (1999) (181)
Differential transactivation of sphingosine-1-phosphate receptors modulates NGF-induced neurite extension (2004) (180)
Sphingosine 1-phosphate rapidly activates the mitogen-activated protein kinase pathway by a G protein-dependent mechanism (1995) (178)
Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts. (2009) (177)
EDG‐1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration (2001) (177)
The Immunomodulator FTY720 Has a Direct Cytoprotective Effect in Oligodendrocyte Progenitors (2007) (173)
KSR stimulates Raf-1 activity in a kinase-independent manner. (1997) (172)
Sphingosine-1-phosphate phosphohydrolase in regulation of sphingolipid metabolism and apoptosis (2002) (171)
Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation (2008) (171)
Sphingosine kinases: a novel family of lipid kinases. (2002) (167)
Genome-wide in vivo screen identifies novel host regulators of metastatic colonization (2017) (166)
Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory (2014) (165)
The lipid phosphatase LPP3 regulates extra-embryonic vasculogenesis and axis patterning (2003) (164)
Exogenous and intracellularly generated sphingosine 1-phosphate can regulate cellular processes by divergent pathways. (2003) (163)
Role of Sphingosine Kinase 2 in Cell Migration toward Epidermal Growth Factor* (2005) (162)
Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin. (2007) (162)
Sphingosine Kinase Type 2 Activation by ERK-mediated Phosphorylation* (2007) (161)
Involvement of a Pertussis Toxin-sensitive G Protein in the Mitogenic Signaling Pathways of Sphingosine 1-Phosphate (*) (1995) (159)
Sphingosine enhances apoptosis of radiation-resistant prostate cancer cells. (2000) (157)
Preferential Signaling and Induction of Allergy-promoting Lymphokines Upon Weak Stimulation of the High Affinity IgE Receptor on Mast Cells (2003) (156)
Sphingosine Kinase Type 1 Induces G12/13-mediated Stress Fiber Formation, yet Promotes Growth and Survival Independent of G Protein-coupled Receptors* (2003) (156)
The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors. (2007) (154)
Identification of Edg1 Receptor Residues That Recognize Sphingosine 1-Phosphate* (2000) (153)
Sphingosine Kinase Modulates Microvascular Tone and Myogenic Responses Through Activation of RhoA/Rho Kinase (2003) (152)
Sphingosine kinase: a mediator of vital cellular functions. (2001) (150)
Arabidopsis Sphingosine Kinase and the Effects of Phytosphingosine-1-Phosphate on Stomatal Aperture1[w] (2005) (147)
Conjugated bile acid–activated S1P receptor 2 is a key regulator of sphingosine kinase 2 and hepatic gene expression (2015) (145)
Sphingosine kinase activity counteracts ceramide-mediated cell death in human melanoma cells: role of Bcl-2 expression (2005) (144)
The S1P2 Receptor Negatively Regulates Platelet-Derived Growth Factor-Induced Motility and Proliferation (2005) (144)
Sphingosine 1-phosphate signaling: providing cells with a sense of direction. (2002) (143)
The nuclear matrix protein, numatrin (B23), is associated with growth factor-induced mitogenesis in Swiss 3T3 fibroblasts and with T lymphocyte proliferation stimulated by lectins and anti-T cell antigen receptor antibody (1988) (140)
Sphingosine-1-phosphate, a metabolite of sphingosine, increases phosphatidic acid levels by phospholipase D activation. (1992) (140)
Export of sphingosine-1-phosphate and cancer progression (2014) (139)
Spns2, a transporter of phosphorylated sphingoid bases, regulates their blood and lymph levels, and the lymphatic network (2013) (137)
Sphingosine generation, cytochrome c release, and activation of caspase-7 in doxorubicin-induced apoptosis of MCF7 breast adenocarcinoma cells (2001) (137)
Endogenous modulators and pharmacological inhibitors of histone deacetylases in cancer therapy (2012) (137)
Nrg-1 Belongs to the Endothelial Differentiation Gene Family of G Protein-coupled Sphingosine-1-phosphate Receptors* (2001) (137)
The Histone Deacetylase Inhibitor MS-275 Interacts Synergistically with Fludarabine to Induce Apoptosis in Human Leukemia Cells (2004) (136)
Essential roles of sphingosine-1–phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema (2010) (133)
Neuropeptide Y induces migration, proliferation, and tube formation of endothelial cells bimodally via Y1, Y2, and Y5 receptors (2006) (132)
The role of sphingosine-1-phosphate in smooth muscle contraction. (2005) (132)
A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell-dependent murine model of allergic asthma. (2013) (130)
Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion. (2008) (128)
Sphingosine 1-phosphate as a therapeutic agent (2002) (128)
Sphingosine‐1‐phosphate stimulates contraction of human airway smooth muscle cells (2003) (128)
Distinct roles of sphingosine kinases 1 and 2 in human mast-cell functions. (2008) (125)
NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress (2019) (124)
Divergence in Signal Transduction Pathways of Platelet-derived Growth Factor (PDGF) and Epidermal Growth Factor (EGF) Receptors (1997) (123)
Targeting the SphK1/S1P/S1PR1 Axis That Links Obesity, Chronic Inflammation, and Breast Cancer Metastasis. (2018) (119)
Conjugated bile acids promote ERK1/2 and AKT activation via a pertussis toxin–sensitive mechanism in murine and human hepatocytes (2005) (119)
Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy (2011) (118)
The roles of sphingosine-1-phosphate in asthma. (2002) (118)
1Alpha,25-dihydroxyvitamin D3 inhibits programmed cell death in HL-60 cells by activation of sphingosine kinase. (1998) (116)
Targeting sphingosine-1-phosphate: a novel avenue for cancer therapeutics. (2006) (115)
Sphingomyelinase and cell-permeable ceramide analogs stimulate cellular proliferation in quiescent Swiss 3T3 fibroblasts. (1992) (115)
Tumor necrosis factor-alpha sensitizes prostate cancer cells to gamma-irradiation-induced apoptosis. (1999) (112)
Regulation of fibroblast functions by lysophospholipid mediators: Potential roles in wound healing (2007) (112)
Sphingosine 1-phosphate stimulates rho-mediated tyrosine phosphorylation of focal adhesion kinase and paxillin in Swiss 3T3 fibroblasts. (1997) (111)
Sphingosine-1-phosphate and lipid phosphohydrolases. (2002) (110)
Involvement of sphingosine kinase in plant cell signalling. (2008) (109)
Ceramide kinase regulates growth and survival of A549 human lung adenocarcinoma cells (2007) (109)
Functional characterization of human sphingosine kinase‐1 (2000) (108)
Gangliosides as bimodal regulators of cell growth. (1987) (108)
Ceramide 1-Phosphate, a Mediator of Phagocytosis* (2005) (108)
Signaling pathways for sphingosylphosphorylcholine-mediated mitogenesis in Swiss 3T3 fibroblasts (1993) (107)
Recycling of Sphingosine Is Regulated by the Concerted Actions of Sphingosine-1-phosphate Phosphohydrolase 1 and Sphingosine Kinase 2* (2007) (107)
Pleiotropic actions of sphingosine-1-phosphate. (2003) (107)
Sphingosylphosphorylcholine is a remarkably potent mitogen for a variety of cell lines. (1991) (106)
Sphingolipid metabolites: Members of a new class of lipid second messengers (1995) (106)
Activation of sphingosine kinase in pheochromocytoma PC12 neuronal cells in response to trophic factors (1997) (103)
K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5 (2014) (100)
Effect of acidic phospholipids on sphingosine kinase (1996) (100)
Direct visualization of redistribution and capping of fluorescent gangliosides on lymphocytes (1984) (98)
RETRACTION: The Histone Deacetylase Inhibitor LAQ824 Induces Human Leukemia Cell Death through a Process Involving XIAP Down-Regulation, Oxidative Injury, and the Acid Sphingomyelinase-Dependent Generation of Ceramide (2006) (98)
Filamin A Links Sphingosine Kinase 1 and Sphingosine-1-Phosphate Receptor 1 at Lamellipodia To Orchestrate Cell Migration (2008) (97)
Sphingosine-1-phosphate in allergic responses, asthma and anaphylaxis. (2007) (96)
Regulation and functions of sphingosine kinases in the brain. (2008) (95)
Fidelity of translesional synthesis past benzo[a]pyrene diol epoxide-2'-deoxyguanosine DNA adducts: marked effects of host cell, sequence context, and chirality. (1996) (93)
Increases in phosphatidic acid levels accompany sphingosine-stimulated proliferation of quiescent Swiss 3T3 cells. (1990) (93)
Dysregulation of sphingolipid metabolism contributes to bortezomib-induced neuropathic pain (2018) (93)
Direct evidence that endogenous GM1 ganglioside can mediate thymocyte proliferation. (1985) (92)
Interleukin-1 Regulates the Expression of Sphingosine Kinase 1 in Glioblastoma Cells* (2009) (91)
Deoxycholic Acid Activates the c-Jun N-terminal Kinase Pathway via FAS Receptor Activation in Primary Hepatocytes (2004) (91)
Vorinostat and sorafenib increase CD95 activation in gastrointestinal tumor cells through a Ca(2+)-de novo ceramide-PP2A-reactive oxygen species-dependent signaling pathway. (2010) (91)
Sphingosine-1-phosphate inhibits motility of human breast cancer cells independently of cell surface receptors. (1999) (91)
Characterization of Murine Sphingosine-1-phosphate Phosphohydrolase* (2002) (90)
Transmembrane signaling by the B subunit of cholera toxin: increased cytoplasmic free calcium in rat lymphocytes (1987) (90)
PERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7/IL-24-induced killing of primary human glioblastoma multiforme cells. (2010) (89)
Sphingosine 1-Phosphate, Present in Serum-derived Lipoproteins, Activates Matriptase* (2002) (86)
Sphingosine-1-phosphate: the Swiss army knife of sphingolipid signaling Supported by National Institutes of Health Grants R37GM043880, RO1CA61774, RO1AI050094, and U19AI077435-018690 (SS) and the NIMH Intramural Research Program (SM). Published, JLR Papers in Press, November 5, 2008. (2009) (86)
Glycosphingolipids and cell death (2003) (85)
Resection of the primary tumor improves survival in metastatic breast cancer by reducing overall tumor burden. (2013) (85)
The phosphorylated prodrug FTY720 is a histone deacetylase inhibitor that reactivates ERα expression and enhances hormonal therapy for breast cancer (2015) (84)
Cloning and Characterization of a Protein Kinase A Anchoring Protein (AKAP)-related Protein That Interacts with and Regulates Sphingosine Kinase 1 Activity* (2002) (84)
Lysophospholipid Receptors in the Nervous System (2002) (83)
Aberrant ORM (yeast)-like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in mice. (2015) (83)
Assaying sphingosine kinase activity. (2000) (81)
Cross-talk at the crossroads of sphingosine-1-phosphate, growth factors, and cytokine signaling. (2008) (81)
Radiation-induced apoptosis mediated by retinoblastoma protein. (1998) (80)
EGF regulates plasminogen activator inhibitor‐1 (PAI‐1) by a pathway involving c‐Src, PKCδ, and sphingosine kinase 1 in glioblastoma cells (2008) (80)
Platelet‐derived growth factor‐induced activation of sphingosine kinase requires phosphorylation of the PDGF receptor tyrosine residue responsible for binding of PLCγ (1999) (79)
Autophagy Induced by Deficiency of Sphingosine-1-phosphate Phosphohydrolase 1 Is Switched to Apoptosis by Calpain-mediated Autophagy-related Gene 5 (Atg5) Cleavage* (2011) (79)
Sphingosine Kinases and Sphingosine-1-Phosphate Are Critical for Transforming Growth Factor β-Induced Extracellular Signal-Regulated Kinase 1 and 2 Activation and Promotion of Migration and Invasion of Esophageal Cancer Cells (2008) (79)
Sphingosine kinase from Swiss 3T3 fibroblasts: a convenient assay for the measurement of intracellular levels of free sphingoid bases. (1994) (78)
Role of Sphingosine-1-Phosphate Phosphohydrolase 1 in the Regulation of Resistance Artery Tone (2008) (78)
Sphingosine 1-phosphate, a novel signaling molecule, stimulates DNA binding activity of AP-1 in quiescent Swiss 3T3 fibroblasts. (1994) (78)
Is tail vein injection a relevant breast cancer lung metastasis model? (2013) (78)
Sphingosine-1-phosphate in chronic intestinal inflammation and cancer. (2014) (76)
OSU-03012 Stimulates PKR-Like Endoplasmic Reticulum-Dependent Increases in 70-kDa Heat Shock Protein Expression, Attenuating Its Lethal Actions in Transformed Cells (2008) (76)
Carnitine palmitoyltransferase 1A functions to repress FoxO transcription factors to allow cell cycle progression in ovarian cancer (2015) (76)
Involvement of focal adhesion kinase in inhibition of motility of human breast cancer cells by sphingosine 1-phosphate. (1999) (76)
Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells (2008) (75)
Novel role of sphingosine kinase 1 as a mediator of neurotrophin‐3 action in oligodendrocyte progenitors (2005) (74)
Incorporation of fluorescent gangliosides into human fibroblasts: mobility, fate, and interaction with fibronectin (1984) (72)
Lipid mediators of angiogenesis and the signalling pathways they initiate. (2002) (72)
Involvement of Sphingosine Kinase in TNF-α-stimulated Tetrahydrobiopterin Biosynthesis in C6 Glioma Cells* (2002) (70)
Biological Characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) as a Selective Sphingosine Kinase-2 Inhibitor and Anticancer Agent (2013) (69)
Ca2+/calmodulin-dependent translocation of sphingosine kinase: role in plasma membrane relocation but not activation. (2003) (68)
Sphingosine 1‐Phosphate: A Ligand for the EDG‐1 Family of G‐Protein‐Coupled Receptors (2000) (68)
A novel role for mitochondrial sphingosine-1-phosphate produced by sphingosine kinase-2 in PTP-mediated cell survival during cardioprotection (2011) (68)
Endogenous ganglioside GM1 modulates L-type calcium channel activity in N18 neuroblastoma cells (1994) (68)
Aminoacylase 1 is a sphingosine kinase 1‐interacting protein (2004) (68)
A new wound healing agent--sphingosylphosphorylcholine. (1996) (67)
Stereospecificity of sphingosine-induced intracellular calcium mobilization and cellular proliferation. (1994) (67)
Sphingosine and Its Analog, the Immunosuppressant 2-Amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol, Interact with the CB1 Cannabinoid Receptor (2006) (66)
The G protein-coupled receptor GPR4 suppresses ERK activation in a ligand-independent manner. (2003) (65)
Glycosphingolipid composition of MDA-MB-231 and MCF-7 human breast cancer cell lines (1998) (65)
Hepatic Apolipoprotein M (ApoM) Overexpression Stimulates Formation of Larger ApoM/Sphingosine 1-Phosphate-enriched Plasma High Density Lipoprotein* (2013) (65)
Ceramide‐induced cell death in primary neuronal cultures: Upregulation of ceramide levels during neuronal apoptosis (2002) (65)
Ceramide plays a prominent role in MDA‐7/IL‐24‐induced cancer‐specific apoptosis (2009) (64)
Sphingosine kinase functionally links elevated transmural pressure and increased reactive oxygen species formation in resistance arteries (2006) (64)
Roles of sphingosine-1-phosphate in cell growth, differentiation, and death. (1998) (63)
Sphingosine-1-phosphate receptor 1 activation in astrocytes contributes to neuropathic pain (2019) (62)
Gangliosides do not move from apical to basolateral plasma membrane in cultured epithelial cells. (1985) (60)
Stimulation of nuclear sphingosine kinase activity by platelet‐derived growth factor (2001) (60)
Spinster 2, a sphingosine‐1‐phosphate transporter, plays a critical role in inflammatory and autoimmune diseases (2015) (60)
Expression of SphK1 impairs degranulation and motility of RBL-2H3 mast cells by desensitizing S1P receptors. (2005) (59)
Shooting the messenger: oxidative stress regulates sphingosine-1-phosphate. (2007) (59)
Development of small-molecule inhibitors of sphingosine-1-phosphate signaling. (2011) (58)
The ORMDL3 Asthma Gene Regulates ICAM1 and Has Multiple Effects on Cellular Inflammation (2019) (57)
The role of sphingosine-1-phosphate and its receptors in asthma. (2008) (56)
Sphingosine and Sphingosine Kinase 1 Involvement in Endocytic Membrane Trafficking* (2017) (56)
The sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 axis regulates early airway T-cell infiltration in murine mast cell-dependent acute allergic responses. (2015) (56)
Role of Sphingosine-1-phosphate Phosphatase 1 in Epidermal Growth Factor-induced Chemotaxis* (2004) (54)
Sphingolipids in metabolic disease: The good, the bad, and the unknown. (2021) (53)
Molecular mechanism of sphingosine-1-phosphate action in Duchenne muscular dystrophy (2013) (53)
Sphingosine‐1‐phosphate receptors mediate neuromodulatory functions in the CNS (2009) (53)
Fluorescent gangliosides as probes for the retention and organization of fibronectin by ganglioside-deficient mouse cells (1985) (51)
Targeting the S1P/S1PR1 axis mitigates cancer-induced bone pain and neuroinflammation (2017) (51)
PERK-dependent regulation of MDA-7/IL-24-induced autophagy in primary human glioma cells (2008) (50)
Mitogenesis of 3T3 fibroblasts induced by endogenous ganglioside is not mediated by cAMP, protein kinase C, or phosphoinositides turnover. (1988) (49)
Sphingosine 1‐phosphate in neural signalling and function (2007) (49)
Copper dependence of angioproliferation in pulmonary arterial hypertension in rats and humans. (2012) (48)
MDA-7/IL-24–induced cell killing in malignant renal carcinoma cells occurs by a ceramide/CD95/PERK–dependent mechanism (2009) (48)
Sphingosine kinase and sphingosine-1-phosphate in liver pathobiology (2017) (48)
ABCC1-Exported Sphingosine-1-phosphate, Produced by Sphingosine Kinase 1, Shortens Survival of Mice and Patients with Breast Cancer (2018) (47)
Sphingosine-1-Phosphate Phosphohydrolase Regulates Endoplasmic Reticulum-to-Golgi Trafficking of Ceramide (2006) (47)
The role of sphingosine in cell growth regulation and transmembrane signaling. (1993) (46)
Sphingosine-1-Phosphate and Interleukin-1 Independently Regulate Plasminogen Activator Inhibitor-1 and Urokinase-Type Plasminogen Activator Receptor Expression in Glioblastoma Cells: Implications for Invasiveness (2008) (46)
Depolarisation induces rapid and transient formation of intracellular sphingosine‐1‐phosphate (2001) (46)
Fibrillar organization of fibronectin is expressed coordinately with cell surface gangliosides in a variant murine fibroblast (1986) (46)
The sphingosine-1-phosphate receptor EDG-1 is essential for platelet-derived growth factor-induced cell motility. (2001) (46)
New insights into functions of the sphingosine-1-phosphate transporter SPNS2 (2019) (45)
PDE5 Inhibitors Enhance Celecoxib Killing in Multiple Tumor Types (2015) (44)
An improved syngeneic orthotopic murine model of human breast cancer progression (2014) (43)
Network modelling reveals the mechanism underlying colitis-associated colon cancer and identifies novel combinatorial anti-cancer targets (2015) (43)
Niemann-Pick type C disease: The atypical sphingolipidosis. (2018) (43)
Structure-activity relationship of short-chain sphingoid bases as inhibitors of sphingosine kinase. (1999) (42)
Sphingosine kinase 1 in breast cancer. (2017) (42)
MSE55, a Cdc42 effector protein, induces long cellular extensions in fibroblasts. (1999) (41)
Sphingosine kinases, sphingosine-1-phosphate and sphingolipidomics. (2005) (41)
Fluorescent reagents for the labeling of glycoconjugates in solution and on cell surfaces. (1980) (41)
IL-4 and TGF-β1 Counterbalance One Another while Regulating Mast Cell Homeostasis (2010) (41)
Structural requirements of sphingosylphosphocholine and sphingosine-1-phosphate for stimulation of activator protein-1 activity. (1996) (41)
Divergence in Regulation of Nitric-oxide Synthase and Its Cofactor Tetrahydrobiopterin by Tumor Necrosis Factor-α (2000) (40)
Calcium influx inhibits MT1‐MMP processing and blocks MMP‐2 activation (1997) (40)
Liposomal ET-18-OCH(3) induces cytochrome c-mediated apoptosis independently of CD95 (APO-1/Fas) signaling. (1999) (39)
FTY720/fingolimod increases NPC1 and NPC2 expression and reduces cholesterol and sphingolipid accumulation in Niemann‐Pick type C mutant fibroblasts (2017) (39)
Synthesis and evaluation of a photolyzable derivative of sphingosine 1-phosphate--caged SPP. (1998) (39)
ORMDL proteins regulate ceramide levels during sterile inflammation (2016) (38)
Sphingosine‐1‐phosphate phosphatase 2 promotes disruption of mucosal integrity, and contributes to ulcerative colitis in mice and humans (2016) (38)
Interaction of ganglioside GM1 with the B subunit of cholera toxin modulates growth and differentiation of neuroblastoma N18 cells (1991) (38)
Ormdl3 and Allergic Asthma: from Physiology to Pathology. (2019) (38)
Sphingosine-1-phosphate and estrogen signaling in breast cancer. (2016) (37)
Novel Sphingolipid‐Based Cancer Therapeutics in the Personalized Medicine Era: CHAPTER TWELVE (2018) (37)
Interstitial Fluid Sphingosine-1-Phosphate in Murine Mammary Gland and Cancer and Human Breast Tissue and Cancer Determined by Novel Methods (2016) (36)
Sphingosylphosphocholine, a signaling molecule which accumulates in Niemann-Pick disease type A, stimulates DNA-binding activity of the transcription activator protein AP-1. (1995) (36)
Involvement of gangliosides in lymphocyte stimulation. (1979) (36)
Innate immune agonist, dsRNA, induces apoptosis in ovarian cancer cells and enhances the potency of cytotoxic chemotherapeutics (2012) (36)
Sphingosine 1-Phosphate Stimulates Tyrosine Phosphorylation of Crk* (1997) (36)
Membrane sialoglycolipids emerging as possible signal transducers for lymphocyte stimulation. (1981) (35)
Enzymatic method for measurement of sphingosine 1-phosphate. (2000) (35)
Inhibition of protein kinase C-dependent cellular proliferation by interaction of endogenous ganglioside GM1 with the B subunit of cholera toxin. (1989) (34)
Asymmetric distribution of gangliosides in rat renal brush-border and basolateral membranes. (1988) (34)
Genotype-Dependent Effects of TGF-β1 on Mast Cell Function: Targeting the Stat5 Pathway (2013) (33)
Lyn but Not Fyn Kinase Controls IgG-Mediated Systemic Anaphylaxis (2012) (33)
Differential effects of sphingomyelinase and cell-permeable ceramide analogs on proliferation of Swiss 3T3 fibroblasts. (1997) (33)
Gangliosides modulate sodium transport in cultured toad kidney epithelia. (1986) (33)
Role of ceramide in mediating apoptosis of irradiated LNCaP prostate cancer cells (2003) (32)
Alkaline ceramidase 1 is essential for mammalian skin homeostasis and regulating whole‐body energy expenditure (2016) (32)
Tumor‐derived exosomes (TDEs): How to avoid the sting in the tail (2019) (32)
Role of ceramide in neuronal cell death and differentiation. (2000) (31)
Sphingoid bases and phospholipase D activation. (1996) (30)
TP53 is required for BECN1- and ATG5-dependent cell death induced by sphingosine kinase 1 inhibition (2018) (30)
Lysophosphatidic acid stimulates gastric cancer cell proliferation via ERK1‐dependent upregulation of sphingosine kinase 1 transcription (2010) (29)
Host sphingosine kinase 1 worsens pancreatic cancer peritoneal carcinomatosis. (2016) (29)
Functional analysis of molecular and pharmacological modulators of mitochondrial fatty acid oxidation (2020) (29)
Sphingosine kinase. Assay and product analysis. (1998) (28)
An integrative study to identify novel scaffolds for sphingosine kinase 1 inhibitors. (2017) (28)
Fluorescent derivatives of ganglioside GM1 function as receptors for cholera toxin. (1985) (27)
Sphingosine-1-phosphate, a novel second messenger involved in cell growth regulation and signal transduction, affects growth and invasiveness of human breast cancer cells (2004) (27)
Ganglioside GM1 and sphingolipid breakdown products in cellular proliferation and signal transduction pathways. (1992) (26)
FTY720/fingolimod decreases hepatic steatosis and expression of fatty acid synthase in diet-induced nonalcoholic fatty liver disease in mice (2019) (26)
Sorafenib and pemetrexed toxicity in cancer cells is mediated via SRC-ERK signaling (2012) (26)
A Serotype 5/3 Adenovirus Expressing MDA-7/IL-24 Infects Renal Carcinoma Cells and Promotes Toxicity of Agents That Increase Ros and Ceramide Levels (2011) (26)
Uncleaved ApoM Signal Peptide Is Required for Formation of Large ApoM/Sphingosine 1-Phosphate (S1P)-enriched HDL Particles* (2015) (26)
A specific ceramide kinase assay to measure cellular levels of ceramide. (2003) (25)
CERAMIDE IN APOPTOSIS AND OXIDATIVE STRESS IN ALLERGIC INFLAMMATION AND ASTHMA. (2020) (25)
Sphingosine-1-phosphate signaling: A novel target for simultaneous adjuvant treatment of triple negative breast cancer and chemotherapy-induced neuropathic pain. (2019) (25)
Non-alcoholic fatty liver disease: Insights from sphingolipidomics. (2018) (24)
Differential regulation of autophagy and cell viability by ceramide species (2015) (24)
VEGF Potentiates GD3-Mediated Immunosuppression by Human Ovarian Cancer Cells (2016) (24)
Sphingosine-1-phosphate synthesis and functions in mast cells. (2008) (24)
Possible involvement of a GTP-binding protein in a late event during endogenous ganglioside-modulated cellular proliferation. (1989) (24)
Sphingosine‐1‐phosphate and the immunosuppressant, FTY720‐phosphate, regulate detrusor muscle tone (2007) (24)
Structural Features of EDG1 Receptor‐Ligand Complexes Revealed by Computational Modeling and Mutagenesis (2000) (24)
Structure of the First Sphingosine 1-Phosphate Receptor (2012) (23)
Sphingosine kinase 1 activation by estrogen receptor α36 contributes to tamoxifen resistance in breast cancer (2018) (23)
Fenretinide Causes Emphysema, Which Is Prevented by Sphingosine 1-Phoshate (2013) (22)
Sphingosine‐1‐phosphate induces development of functionally mature chymase‐expressing human mast cells from hematopoietic progenitors (2009) (22)
Critical role of acylglycerol kinase in epidermal growth factor-induced mitogenesis of prostate cancer cells. (2005) (22)
S1PR1 drives a feedforward signalling loop to regulate BATF3 and the transcriptional programme of Hodgkin lymphoma cells (2017) (22)
Role of Sphingosine Kinase 1 and Sphingosine-1-Phosphate Axis in Hepatocellular Carcinoma. (2019) (22)
Sphingosine-1-phosphate in the lymphatic fluid determined by novel methods (2016) (22)
The role of calcium influx in cellular proliferation induced by interaction of endogenous ganglioside GM1 with the B subunit of cholera toxin. (1995) (22)
Effect of a membrane-targeted sphingosine kinase 1 on cell proliferation and survival. (2005) (22)
The bimodal growth response of Swiss 3T3 cells to the B subunit of cholera toxin is independent of the density of its receptor, ganglioside GM1. (1990) (22)
The potent lipid mitogen sphingosylphosphocholine activates the DNA binding activity of upstream stimulating factor (USF), a basic helix-loop-helix-zipper protein. (1998) (21)
Insertion of ganglioside GM1 into rat glioma C6 cells renders them susceptible to growth inhibition by the B subunit of cholera toxin. (1988) (21)
Targeting sphingosine-1-phosphate in hematologic malignancies. (2011) (21)
A real-time high-throughput fluorescence assay for sphingosine kinases (2014) (20)
Elevated cyclic AMP suppresses ConA-induced MT1-MMP expression in MDA-MB-231 human breast cancer cells (1998) (20)
Sphingosine-1-phosphate Signalling drives an Angiogenic Transcriptional Programme in Diffuse Large B Cell Lymphoma (2019) (20)
Cautionary note on the use of the B subunit of cholera toxin as a ganglioside GM1 probe: Detection of cholera toxin A subunit in B subunit preparations by a sensitive adenylate cyclase assay (1990) (19)
Murine model of long-term obstructive jaundice. (2016) (19)
Modulation of adpative immune responses by sphingosine-1-phosphate (2004) (19)
Filamin A Expression Negatively Regulates Sphingosine-1-Phosphate-Induced NF-κB Activation in Melanoma Cells by Inhibition of Akt Signaling (2015) (19)
Sphingosine and sphingosine 1-phosphate in cellular proliferation: relationship with protein kinase C and phosphatidic acid. (1993) (19)
A novel approach for the topographical localization of glycolipids on the cell surface. (1982) (18)
Sphingosine-1-phosphate activates phospholipase D in human airway epithelial cells via a G protein-coupled receptor. (2000) (18)
Activation of sphingosine-1-phosphate receptor subtype 1 in the central nervous system contributes to morphine-induced hyperalgesia and antinociceptive tolerance in rodents. (2020) (18)
Modified breast cancer model for preclinical immunotherapy studies. (2016) (17)
Synthesis of erythro-ω-aminosphingosine and preparation of an affinity column for sphingosine kinase purification (1996) (17)
A rapid and sensitive method to measure secretion of sphingosine-1-phosphate. (2007) (16)
Measurement of mammalian sphingosine-1-phosphate phosphohydrolase activity in vitro and in vivo. (2007) (16)
Fluorescence labeling of cell surface glycoconjugates with Lucifer yellow CH. (1983) (16)
Involvement of sphingolipids metabolites in cellular proliferation modulated by ganglioside GM1 (1996) (16)
Recognition deficits in mice carrying mutations of genes encoding BLOC‐1 subunits pallidin or dysbindin (2015) (16)
Chemotherapy selection pressure alters sphingolipid composition and mitochondrial bioenergetics in resistant HL-60 cells (2019) (16)
The potential of histone deacetylase inhibitors in Niemann – Pick type C disease (2013) (16)
Sphingosine kinase 1 (2007) (14)
Memo Has a Novel Role in S1P Signaling and Crucial for Vascular Development (2014) (14)
Why is effective treatment of asthma so difficult? An integrated systems biology hypothesis of asthma (2009) (14)
Design of new quinolin-2-one-pyrimidine hybrids as sphingosine kinases inhibitors. (2019) (14)
Dynamic modeling of EDG1 receptor structural changes induced by site-directed mutations (2000) (13)
Sphingosine‐1‐phosphate inhibits IL‐1‐induced expression of C‐C motif ligand 5 via c‐Fos‐dependent suppression of IFN‐β amplification loop (2015) (13)
S1P lyase inhibition protects against sepsis by promoting disease tolerance via the S1P/S1PR3 axis (2020) (13)
Targeting the Sphingosine-1-Phosphate Axis for Developing Non-narcotic Pain Therapeutics. (2020) (13)
Sphingosine-1-phosphate: an emerging therapeutic target (2001) (13)
Sphingosine-1-phosphate: From insipid lipid to a key regulator (2020) (13)
K63-linked polyubiquitylation of IRF1 transcription factor is essential for IL-1-induced CCL5 and CXCL10 chemokine production (2014) (12)
Glycosphingolipids of rat T cells. Predominance of asialo-GM1 and GD1c. (1994) (11)
Sphingosine-1-Phosphate: A Lipid Second Messenger Regulating Cell Growth and Survival (1998) (11)
Inflammatory Conditions Disrupt Constitutive Endothelial Cell Barrier Stabilization by Alleviating Autonomous Secretion of Sphingosine 1-Phosphate (2020) (11)
Modulation of adaptive immune responses by sphingosine-1-phosphate. (2004) (11)
OSU-03012 stimulates PERK-dependent increases in HSP 70 expression , attenuating its lethal actions in transformed cells (2007) (11)
Targeting defective sphingosine kinase 1 in Niemann–Pick type C disease with an activator mitigates cholesterol accumulation (2020) (10)
Targeted lipidomics: signaling lipids and drugs of abuse. (2005) (10)
Neuronal contact upregulates astrocytic sphingosine‐1‐phosphate receptor 1 to coordinate astrocyte‐neuron cross communication (2021) (10)
Regulatory role of SphK1 in TLR7/9‐dependent type I interferon response and autoimmunity (2020) (10)
Role of sphingosine kinase 1 and sphingosine‐1‐phosphate in CD40 signaling and IgE class switching (2014) (10)
CRISPR/Cas9 deletion of ORMDLs reveals complexity in sphingolipid metabolism (2021) (9)
Examination of the role of sphingosine kinase 2 in a murine model of systemic lupus erythematosus (2019) (9)
Fingolimod augments Pemetrexed killing of non-small cell lung cancer and overcomes resistance to ERBB inhibition (2018) (9)
Binding of sphingosine 1-phosphate to cell surface receptors. (2000) (9)
Sphingosine 1-phosphate stimulates Rho-mediated tyrosine phosphorylation of focal adhesion kinase and paxillin in Swiss 3 T 3 fibroblasts (1997) (8)
Sphingosine 1-phosphate signal survival and mitogenesis are mediated by lipid-stereospecific binding of triacylglycerol-rich lipoproteins (2003) (8)
Tumor Necrosis Factor-a Sensitizes Prostate Cancer Cells to g-Irradiation-induced Apoptosis 1 (1999) (7)
[25] Fluorescent gangliosides (1987) (7)
Differential effects of free and liposome‐associated 1‐O‐octadecyl‐2‐O‐methylglycerophosphocholine on protein kinase C (1999) (6)
Synthesis and biological evaluation of sphingosine kinase 2 inhibitors with anti‐inflammatory activity (2019) (6)
A chicken-or-egg conundrum in apoptosis: which comes first? Ceramide or PKCdelta? (2002) (6)
Grafting of triggering site onto lymphocytes; distribution of grafted dinitrophenyl groups on cell surface glycoproteins and glycolipids (2004) (6)
Sphingosine kinase: a closer look at last. (2013) (6)
Thematic Review Series: Sphingolipids. Cross-talk at the crossroads of sphingosine-1-phosphate, growth factors, and cytokine signaling*1 (2008) (5)
Progress towards Understanding the Role of Gangliosides in Cell Growth Regulation (1990) (5)
Sphingosine-1-Phosphate: Member of a New Class of Lipid Second Messengers (1997) (5)
A new preclinical model of western diet‐induced progression of non‐alcoholic steatohepatitis to hepatocellular carcinoma (2022) (4)
Interaction of the B subunit of cholera toxin with endogenous ganglioside GM1 causes changes in membrane potential of rat thymocytes (1989) (4)
Lipids and apoptosis: foreword (2002) (4)
Structure—Activity Relationship of Short-Chain Sphingoid Bases as Inhibitors of Sphingosine Kinase. (2000) (4)
Dye-free spectrophotometric measurement of nucleic acid-to-protein ratio for cell-selective extracellular vesicle discrimination. (2021) (4)
Abstract 14772: A Novel Role For Sphingosine Kinase-2 In PTP-mediated Cell Survival During Cardioprotection (2011) (4)
Sphingosine-1-phosphate receptor 1 activation in the central nervous system drives cisplatin-induced cognitive impairment (2022) (3)
10 Sphingosine-1-phosphate metabolism in mammalian cell signalling (2004) (3)
Abstract P1-01-06: Targeting the SphK1/S1P/S1PR1 axis that connects obesity, chronic inflammation, and breast cancer metastasis (2018) (3)
Synthesis and Evaluation of a Photolyzable Derivative of Sphingosine 1-Phosphate—Caged SPP. (1998) (3)
Sphingosine kinases regulate ER contacts with late endocytic organelles and cholesterol trafficking (2022) (3)
Deletion or inhibition of SphK1 mitigates fulminant hepatic failure by suppressing TNFα‐dependent inflammation and apoptosis (2021) (3)
Invasion of Esophageal Cancer Cells 2 Activation and Promotion of Migration andExtracellular Signal-Regulated Kinase 1-Induced β Transforming Growth Factor Sphingosine-1-Phosphate Are Critical for Sphingosine Kinases and (2008) (2)
Targeting defective sphingosine kinase 1 in Niemann-Pick type C disease with an activator mitigates cholesterol accumulation. (2020) (2)
Specific inhibitor of sphingosine kinase 1 suppresses tumor-induced angiogenesis and lymphangiogenesis (2011) (2)
A2 independently of sphingosine-1-phosphate receptors The immunosuppressant drug FTY720 inhibits cytosolic phospholipase (2013) (2)
Sphingosine-1-Phosphate Receptors (2003) (2)
Cell membranes, methods and reviews. Volume 3. Plenum Press, New York, 1987. 417 pp. $75.00 (1989) (2)
Diacylglycerol Lipase-β Knockout Mice Display a Sex-Dependent Attenuation of Traumatic Brain Injury-Induced Mortality with No Impact on Memory or Other Functional Consequences. (2021) (2)
The distribution of BrK alpha/RbK alpha peak intensity ratio in human whole blood samples. Comparison between normal and colorectal cancer cases. (1994) (2)
Correction: S1PR1 drives a feedforward signalling loop to regulate BATF3 and the transcriptional programme of Hodgkin lymphoma cells (2019) (2)
VEGF potentiates GD 3-mediated immune suppression by human ovarian cancer cells (2016) (2)
Sphingosine, a Breakdown Product of Cellular Sphingolipids, in Cellular Proliferation and Phospholipid Metabolism (1993) (2)
Uncleaved apoM signal peptide is required for formation of large apoM/S1P-enriched HDL particles ‡ (2015) (2)
Sphingosine-1-phosphate receptor subtype 1 activation in the central nervous system contributes to morphine withdrawal in rodents (2020) (2)
Sphingosine kinase 1 mediates sexual dimorphism in fibrosis in a mouse model of NASH (2022) (2)
Activation of Sphingosine Kinase 1 (2006) (1)
Abstract P5-03-05: Sphingosine-1-phosphate produced by sphingosine kinase 1 and exported via ABCC1 shortens survival of mice and humans with breast cancer (2018) (1)
Sphingosine‐1‐Phosphate: A Bridge From Bench To Clinic (2016) (1)
Role of sphingolipid metabolites in the actions of growth factors and cytokines (1996) (1)
Sphingosine Kinase 2 and S1P in the Nucleus Regulate Histone Acetylation by Inhibition of Histone Deacetylases (2010) (1)
Sphingosine-1-Phosphate - A New Lipid Signaling Molecule (1996) (1)
Fluorescent gangliosides. (1987) (1)
Identification of Direct Intracellular Targets of Sphingosine 1‐Phosphate (S1P) (2013) (1)
Ceramide as a Key Player in Obesity Exacerbated Asthma (2019) (1)
A simple method for sphingolipid analysis of tissues embedded in optimal cutting temperature compound. (2020) (1)
Effects of N,N‐Dimethylsphingosine on Sphingosine Kinase (2006) (1)
Lysophospholipid (LPA) receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database (2019) (1)
Sphingosine-1-phosphate Inhibits Motility of Human Breast Cancer Cells Independently of Cell Surface Receptors 1 (1999) (1)
Sphingosine kinase 2 in stromal fibroblasts creates a hospitable tumor microenvironment in breast cancer. (2022) (1)
Sphingosine Kinase 2 (2007) (1)
The S1P/S1PR2 axis regulates early airway T cell infiltration in murine mast cell-dependent acute allergic responses (2015) (1)
Abstract 19183: Overexpression of Apom in Liver Stimulates Formation of Larger, Apom/S1P-Enriched Plasma HDL (2013) (1)
A simple method for sphingolipid analysis of tissues embedded in optimal cutting temperature compound[S] (2020) (1)
Editorial for BBRC lipidomics special issue. (2018) (1)
Radiation-induced Apoptosis Mediated by KetiIK Â»blastoma Protein1 (1998) (1)
Lysophospholipid (S1P) receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database (2019) (1)
Bioactive lipids and metabolic syndrome—a symposium report (2022) (1)
Expression of SphK 1 impairs degranulation and motility of RBL-2 H 3 mast cells by desensitizing S 1 P receptors (2005) (1)
The role of sphingosine kinase in plant cell signalling (2008) (1)
Regulation of p21 Expression by Sphingosine Kinase 2 (2009) (0)
Estradiol Stimulates Export of Sphingosine‐1‐Phosphate From MCF7 Breast Cancer Cells By Specific ABC Transporters (2009) (0)
Sphingosine-1-phosphate induces mitogenesis and alterations in intracellular calcium (Ca2+) in vascular smooth muscle cells (1996) (0)
Oxidative Stress Regulates Sphingosine-1-Phosphate (2006) (0)
BENZOTHOPHENES AND INDOLES AS EDG RECEPTORAGONSTS CROSS REFERENCE TO RELATED APPLICATIONS (2017) (0)
Abstract 4419: Effect of sphingosine kinase 1 inhibition in validated syngeneic mouse breast cancer metastasis model (2011) (0)
Targeting Sphingosine-1-Phosphate Signaling with FTY720 Suppresses Colon Cancer Peritoneal Carcinomatosis Progression in Both CT26 Syngeneic and HCT116 Xenograft Models (2014) (0)
New aspects of sphingosine-1-phosphate in inflammation, cancer progression, and metastasis (2017) (0)
Involvement of gangliosides in lymphocyte stimulation ( exogenous gangliosides / dinitrophenyl-gangliosides / antibodies against dinitrophenyl groups ) (0)
Lysophospholipid ( S 1 P ) receptors ( version 2019 . 4 ) in the IUPHAR / BPS Guide to Pharmacology Database (2019) (0)
Issue Information (2020) (0)
Function of Gangliosides in Cellular Proliferation (2020) (0)
FTY720, a Sphingosine-1-phosphate receptor modulator, as a novel targeted therapy against colitis-associated cancer (2014) (0)
Sunday, 18 July 2010 (2010) (0)
Sphingosine Kinase 2, an Evil Kinase? (2008) (0)
Targeting the S1P Axis and Development of a Novel Therapy for Obesity Related Triple Negative Breast Cancer (2015) (0)
Sphingosine‐1‐Phosphate Induces Contraction of Floating and Stressed Fibroblast‐Populated Collagen Matrices (2007) (0)
Abstract 4364: S1P generated by SphK1 is important not only for primary tumor growth but also for tumor-induced hemangiogenesis and lymphangiogenesis (2012) (0)
Sphingosine-1-phosphate receptor subtype 1 activation in the central nervous system contributes to morphine withdrawal in rodents (2020) (0)
CHAPTER 163 – Sphingosine-1-Phosphate Receptors (2003) (0)
Development of a New Method to Measure Sphingosine-1-phosphate in Tumor Interstitial Fuid by Liquid Chromatography-Electrospray Ionization Tandem Mass Spectrometry (2013) (0)
04-1-0393 TITLE : The Role of Sphingosine Kinase 2 in Apoptosis of Human Breast Cancer (0)
Nuclear SphK2 and S1P regulate Stat3 acetylation and transcriptional activity (2011) (0)
Introduction to the special issue on sphingolipid signaling in chronic disease. (2018) (0)
Hait Sphingosine-1-Phosphate Regulation of Histone Acetylation in the Nucleus (2010) (0)
Functional analysis of molecular and pharmacological modulators of mitochondrial fatty acid oxidation (2020) (0)
This information is current as Homeostasis Another while Regulating Mast Cell 1 Counterbalance One β IL-4 and (2010) (0)
la,25-Dihydroxyvitamin D3 Inhibits Programmed Cell Death in HL-60 Cells by Activation of Sphingosine Kinase1 (2006) (0)
Analysis of Liver Responses to Non-alcoholic Steatohepatitis by mRNA-Sequencing. (2022) (0)
Abstract P6-06-27: Expression of ATP-binding cassette transporter C1 (ABCC1) and activated sphingosine kinase 1 in breast cancer are associated with significantly shorter disease free survival (2013) (0)
Issue Information (2020) (0)
A Novel Function of the Immunosuppressant Drug FTY720 Independent of Its Phosphorylation as a Direct Cytosolic Phospholipase A2 Inhibitor (2006) (0)
Non-Genomic ER-Alpha but Not GPR30 Is Involved in Estradiol-Mediated Release of Sphingosine-1-Phosphate from Breast Cancer (2010) (0)
Regulation of Cell Survival and Motility in Human Breast Cancer Cells by Sphingosine Kinase (2002) (0)
to Promote Gastric Cancer Cell Motility and Invasion Receptors Mediates Up-regulation of Sphingosine Kinase 1 and Epidermal Growth Factor 1 Cross-talk between LPA (2008) (0)
Abstract LB-325: Sphingosine-1-phosphate links chronic intestinal inflammation to development of colitis-associated cancer. (2013) (0)
Abstract 112: FTY720-P is a potent inhibitor of class I histone deacetylases that enhances histone acetylation, reactivates ERα expression, and increases hormonal therapeutic sensitivity of breast cancer (2015) (0)
The Preclinical Development of FTY720, A Sphingosine-1-Phosphate Receptor Modulator, as a Novel Targeting Therapy Against Breast Cancer (2012) (0)
The Role of Sphingosine Kinase 2 in Apoptosis of Human Breast Cancer Cells (2007) (0)
Sphingosine‐1‐phosphate phosphohydrolase 1 functionally antagonizes the microvascular effects of sphingosine kinase 1 and its metabolite sphingosine‐1‐phosphate (2007) (0)
therapeutic targets in human leukemia A selective sphingosine kinase 1 inhibitor integrates multiple molecular (2013) (0)
Co-Expression of Activated Sphingosine Kinase 1 and ATP-Binding Cassette Transporter C1 (ABCC1) in Breast Cancer is Associated with Significantly Shorter Disease Free Survival (2014) (0)
N,N‐Dimethylsphingosine Induces Apoptosis by Inhibiting Sphingosine Kinase but Not Protein Kinase C (1998) (0)
S1727 Distinct Role of Sphingosine Kinase 2 in Dextran Sulfate Sodium-Induced Colitis (2010) (0)
Appropriateness of Models of Cancer Cell Implantation to Study Breast Cancer Lung Metastasis Evaluated by Genome-Wide Microarray Analysis (2013) (0)
Novel Animal Model For Ceramide Induced Emphysema In Rat Lung (2011) (0)
Abstract 5000: Spinster 2 exports S1P, an important player in lymph node metastasis. (2013) (0)
Copper Chelation Mediated Resolution Of Angioproliferative Lesions In Experimental Pulmonary Hypertension Is Associated With An Altered Ceramide/sphingosine-1 Phosphate Balance (2011) (0)
Targeting the Sphingosine-1-phosphate Signaling with FTY720 in Obesity Related Breast Cancer Progression (2014) (0)
The distribution of BrKα/RbKα peak intensity ratio in human whole blood samples (1994) (0)
Role of Lysophospholipids in Cell Growth and Survival (2007) (0)
Lysophosphatidic Acid Regulation and Roles in Human Prostate Cancer (2005) (0)
Primary Human Glioblastoma Multiforme Cells Induced Killing of −-7 / IL-24 mda Thioredoxin Play a Key Role in Dependent Regulation of Ceramide Synthase 6 and − (2010) (0)
Abstract 3280: The sphingosine-1-phosphate receptor modulator FTY720 synergistically inhibits colon cancer cell growth with 5-fluorouracil, irinotecan and oxaliplatin. (2013) (0)
Neutrophilia in severe asthma is reduced in Ormdl3 overexpressing mice (2023) (0)
Sphingosine-1-phosphate Receptor Modulator, FTY720, Synergizes with 5-fluorouracil and Prolongs Survival in a CT26 Syngeneic Murine Colon Cancer Carcinomatosis Model (2014) (0)
Abstract 1694: Conjugated bile acids aggravate metastatic pancreatic cancer via sphingosine-1-phosphate receptor 2 (2016) (0)
The ORMDL3-ceramide axis may be a novel therapeutic target for the control of allergic airway disease (2016) (0)
The Sphingosine-1-phosphate Receptor Modulator, FTY720, Synergizes With 5-FU to Inhibit Growth of Human Colon Cancer Cells (2013) (0)
Type 2 isoforms of sphingosine kinase mammalian cloning, expression, and methods of use thereof (2001) (0)
Novel Regulation of Cell Growth by Endogenous Gangliosides (2020) (0)
Sphingosine‐1‐Phosphate: a missing cofactor for lysine 63‐linked poly‐ubiquitinations in signaling by pro‐inflammatory cytokines (2011) (0)
Clonage, expression et procedes d'utilisation de la sphingosine kinase (1999) (0)
Sphingolipid Metabolites in Signal Transduction (2000) (0)
Abstract 407: FTY720 suppressed CT26 murine colon cancer peritoneal carcinomatosis progression by decreasing tumor associated macrophages and TNF-alpha (2015) (0)
Abstract 4503: Targeting sphingosine kinase 1 is promising novel strategy against breast cancer (2010) (0)
Iconographies supplémentaires de l'article : A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell–dependent murine model of allergic asthma (2013) (0)
Abstract 475: Resection of primary tumor improves survival in mouse metastatic breast cancer model (2010) (0)
Role of sphingosine-1-phosphate in estrogen receptor signaling in breast cancer (2017) (0)
ORMDL in metabolic health and disease. (2023) (0)
Correction (2020) (0)
Abstract 4884: Determination of sphingosine-1-phosphate levels in tissue interstitial fluid and lymphatic fluid utilizing novel collection techniques (2014) (0)
Abstract 4887: FTY720 prevent tumorigenesis and suppress the progression of colitis-associated cancer. (2013) (0)
Cancer and Inflammation (2016) (0)
Oral Presentation OR1: Myelin, Oligodendrocyte, and Schwann Cell Biology (2004) (0)
Abstract 1890: Activated SphK1 and export of S1P via ABCC1 shorten disease free survival in breast cancer (2014) (0)
Genotype-Dependent Effects of TGF- (2013) (0)
as an Effector Protein Rab 35 Controls Actin Bundling by Recruiting Fascin (2009) (0)
Erratum: FTY720/fingolimod decreases hepatic steatosis and expression of fatty acid synthase in diet-induced nonalcoholic fatty liver disease in mice (2020) (0)
Role of Sphingosine Kinase in Radiation-Induced Apoptosis of Human Prostate Cancer Cells (2000) (0)
Preclinical models of nonalcoholic steatohepatitis Leading to hepatocellular carcinoma (2022) (0)
Independently of CD95 (APO-1/Fas) Signaling Liposomal ET-18-OCH3 Induces Cytochrome c-Mediated Apoptosis (2013) (0)
Regulation of Autophagy by Sphingosine‐1‐Phosphate Phosphohydrolase 1 (2009) (0)
Abstract 5280: Activation of sphingosine kinase 1 is necessary for angiopoietin 2-induced hemangiogenesis and lymphangiogenesis (2012) (0)
Sphingosine-1-Phosphate ( S 1 P ) Stimulation Decreases Vascular Endothelial Growth Factor ( VEGF ) and Interleukin-8 ( IL-8 ) Secretion in Follicular Thyroid Cancer Cell Lines in Vitro (2008) (0)
Abstract P2-05-06: Does the lipid mediator sphingosine-1-phosphate have a role in obesity-related cancer progression? (2013) (0)
Tumor Associated Macrophages and TNF-Alpha Production in CT26 Syngeneic Murine Colon Cancer Peritoneal Carcinomatosis can be Suppressed by Inhibition of Sphingosine-1-Phosphate Signaling (2014) (0)
Targeting sphingosine‐1‐phosphate receptors regulates in vitro and in vivo mast cell functions (2008) (0)
Sphingosine-1-phosphate and its receptors in vascular endothelial and lymphatic barrier function. (2023) (0)
- 14-1-0086 TITLE : Targeting the S 1 P Axis and Development of a Novel Therapy for Obesity-Related Triple-Negative Breast Cancer (2017) (0)
Number : DAMD 17-021-0060 TITLE : Lysophosphatidic Acid Regulation and Roles in Human Prostate Cancer (0)
Award Number: W81XWH-04-1-0393 TITLE: The Role of Sphingosine Kinase 2 in Apoptosis of Human Breast Cancer Cells (2006) (0)
Abstract 4103: Sphingosine kinase-1 mediates LPA-induced gastric cancer cell proliferation (2010) (0)
Sphingosine-1-phosphate Prevents SU5416-induced Emphysema Via Endothelial Hypoxia Inducible Factor-1 Alpha Induction (2010) (0)
IgG-Mediated Systemic Anaphylaxis Lyn but Not Fyn Kinase Controls (2012) (0)
Sphingosine kinase 1 inhibition modulates crosstalk between p53 and autophagic cell death (2017) (0)
S3.2 Ganglioside GM1 and its metabolites in cell growth, differentiation and transmembrane signalling (1993) (0)
Targeting Breast Cancer Metastasis Using FTY720 (2012) (0)
Sphingosine 1-phosphate in neural signalling and function. Commentary (2007) (0)
In Memoriam: Roscoe Owen Brady (1923–2016) (2016) (0)
Effect of Sphingosine-1-Phosphate Signaling Disruption in a Murine Synergenic Metastatic Breast Cancer Model (2014) (0)
Abstract 2695: FTY720 as a novel therapeutic approach for colon cancer carcinomatosis (2014) (0)
Estradiol-Induced Sphingosine-1-Phosphate Is Released via ABCC1 and ABCG2, and Activates ERK1/2 (2010) (0)
Sphingosine-1-Phosphate: Signaling Inside and Out (2000) (0)
20th Plastics Technology Colloquium - Special issue (2000) (0)
Sphingolipids Metabolites: A New Class of Second Messengers in the Regulation of Cell Growth (1994) (0)

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