Saverio Minucci
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Biology
Saverio Minucci's Degrees
- Bachelors Biology University of Milan
- Masters Molecular Biology University of Milan
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(Suggest an Edit or Addition)Saverio Minucci's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012) (2913)
- Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer (2006) (2137)
- Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells (2001) (1785)
- The tripartite motif family identifies cell compartments (2001) (1286)
- Electron Transfer between Cytochrome c and p66Shc Generates Reactive Oxygen Species that Trigger Mitochondrial Apoptosis (2005) (1072)
- Fusion proteins of the retinoic acid receptor-α recruit histone deacetylase in promyelocytic leukaemia (1998) (1064)
- The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. (2007) (897)
- Human SIR2 deacetylates p53 and antagonizes PML/p53‐induced cellular senescence (2002) (881)
- PML regulates p53 acetylation and premature senescence induced by oncogenic Ras (2000) (865)
- Methyltransferase Recruitment and DNA Hypermethylation of Target Promoters by an Oncogenic Transcription Factor (2002) (822)
- The Tumor Suppressor p53 Regulates Polarity of Self-Renewing Divisions in Mammary Stem Cells (2009) (714)
- Aberrant Recruitment of the Nuclear Receptor Corepressor-Histone Deacetylase Complex by the Acute Myeloid Leukemia Fusion Partner ETO (1998) (533)
- Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway (2005) (529)
- Protein Kinase C ß and Prolyl Isomerase 1 Regulate Mitochondrial Effects of the Life-Span Determinant p66Shc (2007) (468)
- A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis (2002) (436)
- The histone acetylase PCAF is a nuclear receptor coactivator. (1998) (407)
- HDACs link the DNA damage response, processing of double-strand breaks and autophagy (2011) (377)
- The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery (2016) (360)
- Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells (2009) (321)
- BLUEPRINT to decode the epigenetic signature written in blood (2012) (320)
- Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer (2011) (315)
- Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation. (2000) (303)
- Biochemical, structural, and biological evaluation of tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and LSD2. (2010) (256)
- Histone deacetylase-targeted treatment restores retinoic acid signaling and differentiation in acute myeloid leukemia. (2001) (252)
- Role of the polycomb repressive complex 2 in acute promyelocytic leukemia. (2007) (248)
- Histone deacetylases: a common molecular target for differentiation treatment of acute myeloid leukemias? (2001) (204)
- Inhibition of histone deacetylases in cancer therapy: lessons from leukaemia (2016) (196)
- PML NBs associate with the hMre11 complex and p53 at sites of irradiation induced DNA damage (2002) (195)
- Retinoid X receptor (RXR) within the RXR-retinoic acid receptor heterodimer binds its ligand and enhances retinoid-dependent gene expression (1997) (175)
- ERRATUM: Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway (2005) (174)
- Activation of Rac1 and the p38 Mitogen-activated Protein Kinase Pathway in Response to All-trans-retinoic Acid* (2001) (162)
- Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis. (2019) (160)
- p66Shc-generated Oxidative Signal Promotes Fat Accumulation* (2008) (158)
- Activation of a promyelocytic leukemia–tumor protein 53 axis underlies acute promyelocytic leukemia cure (2014) (155)
- Reduced body size and decreased intestinal tumor rates in HDAC2-mutant mice. (2007) (150)
- Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis (2017) (146)
- Blood orange juice inhibits fat accumulation in mice (2010) (141)
- Involvement of the Histone Deacetylase SIRT1 in Chicken Ovalbumin Upstream Promoter Transcription Factor (COUP-TF)-interacting Protein 2-mediated Transcriptional Repression* (2003) (135)
- HDAC-regulated myomiRs control BAF60 variant exchange and direct the functional phenotype of fibro-adipogenic progenitors in dystrophic muscles (2014) (133)
- Impairment of p53 acetylation, stability and function by an oncogenic transcription factor (2004) (129)
- Activation of Rac1 and the p38 Mitogen-activated Protein Kinase Pathway in Response to Arsenic Trioxide* (2002) (127)
- Histone deacetylases and epigenetic therapies of hematological malignancies. (2010) (120)
- MBD3, a Component of the NuRD Complex, Facilitates Chromatin Alteration and Deposition of Epigenetic Marks (2008) (118)
- Retinoid receptors in health and disease: co-regulators and the chromatin connection. (1999) (118)
- Recruitment of the Histone Methyltransferase SUV39H1 and Its Role in the Oncogenic Properties of the Leukemia-Associated PML-Retinoic Acid Receptor Fusion Protein (2006) (114)
- A dual role for Hdac1: oncosuppressor in tumorigenesis, oncogene in tumor maintenance. (2013) (113)
- A histone deacetylase inhibitor potentiates retinoid receptor action in embryonal carcinoma cells. (1997) (113)
- Retinoic acid‐mediated down‐regulation of Oct3/4 coincides with the loss of promoter occupancy in vivo. (1996) (113)
- Oligomerization of ETO Is Obligatory for Corepressor Interaction (2001) (112)
- PML-RAR induces promyelocytic leukemias with high efficiency following retroviral gene transfer into purified murine hematopoietic progenitors. (2002) (112)
- Inhibition of histone deacetylase activity on specific embryonic tissues as a new mechanism for teratogenicity. (2005) (111)
- Histone deacetylase inhibitors as a new weapon in the arsenal of differentiation therapies of cancer. (2009) (109)
- Modulation of pro- and anti-apoptotic factors in human melanoma cells exposed to histone deacetylase inhibitors (2004) (107)
- Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion (2015) (101)
- Activation of Protein Kinase Cδ by All-trans-retinoic Acid* (2003) (97)
- Common themes in the pathogenesis of acute myeloid leukemia (2001) (90)
- The methyl-CpG binding protein MBD1 is required for PML-RARα function (2006) (88)
- c-Myc Modulation and Acetylation Is a Key HDAC Inhibitor Target in Cancer (2016) (87)
- A comprehensive review of lysine-specific demethylase 1 and its roles in cancer. (2017) (83)
- A phase I–II study of the histone deacetylase inhibitor valproic acid plus chemoimmunotherapy in patients with advanced melanoma (2009) (82)
- MOZ-TIF2 Inhibits Transcription by Nuclear Receptors and p53 by Impairment of CBP Function (2005) (74)
- RAR and RXR selective ligands cooperatively induce apoptosis and neuronal differentiation in P19 embryonal carcinoma cells (1996) (73)
- Dominant negative retinoid X receptor beta inhibits retinoic acid-responsive gene regulation in embryonal carcinoma cells (1994) (73)
- Histone modification therapy of cancer. (2010) (72)
- Beclin 1 restrains tumorigenesis through Mcl-1 destabilization in an autophagy-independent reciprocal manner (2014) (72)
- SILAC-based proteomic analysis to dissect the “histone modification signature” of human breast cancer cells (2011) (72)
- Overexpression of sPRDM16 coupled with loss of p53 induces myeloid leukemias in mice. (2007) (72)
- Suppressive effects of statins on acute promyelocytic leukemia cells. (2007) (72)
- Loss of pericentromeric DNA methylation pattern in human glioblastoma is associated with altered DNA methyltransferases expression and involves the stem cell compartment (2008) (71)
- The Coiled-coil Domain Is the Structural Determinant for Mammalian Homologues of Drosophila Sina-mediated Degradation of Promyelocytic Leukemia Protein and Other Tripartite Motif Proteins by the Proteasome* (2004) (68)
- Ligand-dependent occupancy of the retinoic acid receptor beta 2 promoter in vivo (1994) (67)
- Efficient Inhibition of Activation-induced Fas Ligand Up-regulation and T Cell Apoptosis by Retinoids Requires Occupancy of both Retinoid X Receptors and Retinoic Acid Receptors (*) (1995) (66)
- Constitutive degradation of PML/RARalpha through the proteasome pathway mediates retinoic acid resistance. (1999) (66)
- Pathology tissue–chromatin immunoprecipitation, coupled with high-throughput sequencing, allows the epigenetic profiling of patient samples (2010) (63)
- Chromatin accessibility, p300, and histone acetylation define PML-RARα and AML1-ETO binding sites in acute myeloid leukemia. (2012) (62)
- Cinnamic anilides as new mitochondrial permeability transition pore inhibitors endowed with ischemia-reperfusion injury protective effect in vivo. (2014) (61)
- Acquired CYP19A1 amplification is an early specific mechanism of aromatase inhibitor resistance in ERα metastatic breast cancer (2017) (61)
- Retinoid receptors in transcriptional regulation. (1996) (61)
- Chromatin immunoprecipitation and high-throughput sequencing from paraffin-embedded pathology tissue (2011) (60)
- NA-Seq: a discovery tool for the analysis of chromatin structure and dynamics during differentiation. (2009) (59)
- New method to detect histone acetylation levels by flow cytometry (2005) (59)
- Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent. (2016) (57)
- In Vivo Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype. (2016) (57)
- Clonal evolution of acute myeloid leukemia with FLT3-ITD mutation under treatment with midostaurin. (2021) (55)
- Retinoids Induce Fibroblast Growth Factor-2 Production in Endothelial Cells via Retinoic Acid Receptor &agr; Activation and Stimulate Angiogenesis In Vitro and In Vivo (2001) (55)
- The methyl-CpG binding protein MBD1 is required for PML-RARalpha function. (2006) (55)
- Valproic acid induces differentiation and transient tumor regression, but spares leukemia-initiating activity in mouse models of APL (2012) (52)
- PML4 induces differentiation by Myc destabilization (2007) (52)
- Fragment‐based Identification of Hsp90 Inhibitors (2009) (50)
- Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 1: High-Throughput Screening and Preliminary Exploration. (2017) (49)
- Fasting-Mimicking Diet Is Safe and Reshapes Metabolism and Antitumor Immunity in Patients with Cancer (2021) (48)
- Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship. (2017) (48)
- Functional-genetic dissection of HDAC dependencies in mouse lymphoid and myeloid malignancies. (2015) (48)
- Entinostat for the treatment of breast cancer (2017) (46)
- Synthesis, biological activity and mechanistic insights of 1-substituted cyclopropylamine derivatives: a novel class of irreversible inhibitors of histone demethylase KDM1A. (2014) (46)
- Retinoid X receptor-selective ligands produce malformations in Xenopus embryos. (1996) (46)
- Epigenomic profiling of cancer cells. (2009) (46)
- Discovery, synthesis, and pharmacological evaluation of spiropiperidine hydroxamic acid based derivatives as structurally novel histone deacetylase (HDAC) inhibitors. (2011) (45)
- Epigenetic therapies in haematological malignancies: searching for true targets. (2009) (44)
- Mechanisms of Selective Anticancer Action of Histone Deacetylase Inhibitors (2005) (43)
- miR-194-5p/BCLAF1 deregulation in AML tumorigenesis (2017) (43)
- Epigenetic alterations in acute myeloid leukemias (2015) (43)
- Activation of the p70 S6 kinase by all-trans-retinoic acid in acute promyelocytic leukemia cells. (2005) (43)
- Retinoid-induced chromatin structure alterations in the retinoic acid receptor beta2 promoter (1997) (43)
- Dual modulation of MCL-1 and mTOR determines the response to sunitinib (2017) (42)
- Molecular and Biologic Analysis of Histone Deacetylase Inhibitors with Diverse Specificities (2013) (41)
- In vitro and in vivo hematopoietic potential of human stem cells residing in muscle tissue. (2002) (41)
- Activation of protein kinase C delta by all-trans-retinoic acid. (2003) (40)
- Acetylation: a novel link between double-strand break repair and autophagy. (2012) (40)
- Retinoic Acid Receptor α Fusion to PML Affects Its Transcriptional and Chromatin-Remodeling Properties (2003) (38)
- Constitutive degradation of PML/RARα through the proteasome pathway mediates retinoic acid resistance (1999) (36)
- Targeting the scaffolding role of LSD1 (KDM1A) poises acute myeloid leukemia cells for retinoic acid–induced differentiation (2020) (36)
- Pathology Tissue-quantitative Mass Spectrometry Analysis to Profile Histone Post-translational Modification Patterns in Patient Samples* (2015) (36)
- Surmounting the resistance against EGFR inhibitors through the development of thieno[2,3-d]pyrimidine-based dual EGFR/HER2 inhibitors. (2018) (35)
- PML nuclear body disruption impairs DNA double-strand break sensing and repair in APL (2016) (35)
- Diagnosis of vascular diseases. Ultrasound investigations--guidelines. (2012) (35)
- Epigenetic gene silencing in acute promyelocytic leukemia. (2004) (34)
- Next generation histone deacetylase inhibitors: the answer to the search for optimized epigenetic therapies? (2011) (33)
- Synthesis and biological evaluation of N-hydroxyphenylacrylamides and N-hydroxypyridin-2-ylacrylamides as novel histone deacetylase inhibitors. (2010) (33)
- Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356 (2016) (33)
- Molecular Pathways: Old Drugs Define New Pathways: Non-Histone Acetylation at the Crossroads of the DNA Damage Response and Autophagy (2012) (32)
- Editorial :Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). DOI: 10.1080/15548627.2015.1100356;WOS:000373595400001; 2-s2.0-85013763791&;PMID: 26799652 (2016) (31)
- Inhibition of ligand induced promoter occupancy in vivo by a dominant negative RXR (1996) (30)
- PP2A Controls Genome Integrity by Integrating Nutrient-Sensing and Metabolic Pathways with the DNA Damage Response (2017) (30)
- The self-association coiled-coil domain of PML is sufficient for the oncogenic conversion of the retinoic acid receptor (RAR) alpha (2011) (29)
- The DNA demethylating agent decitabine activates the TRAIL pathway and induces apoptosis in acute myeloid leukemia. (2013) (28)
- Extensive and systematic rewiring of histone post-translational modifications in cancer model systems (2018) (27)
- Pure enantiomers of benzoylamino-tranylcypromine: LSD1 inhibition, gene modulation in human leukemia cells and effects on clonogenic potential of murine promyelocytic blasts. (2015) (27)
- Functional characterization of a novel FGFR1OP‐RET rearrangement in hematopoietic malignancies (2014) (26)
- Identification of mutations associated with acquired resistance to sunitinib in renal cell cancer (2019) (25)
- Rad51/BRCA2 disruptors inhibit homologous recombination and synergize with olaparib in pancreatic cancer cells. (2019) (25)
- Alterations of Histone Modifications in Cancer (2012) (24)
- G1 cell-cycle arrest and apoptosis by histone deacetylase inhibition in MLL-AF9 acute myeloid leukemia cells is p21 dependent and MLL-AF9 independent (2006) (24)
- Sex-based dimorphism of anticancer immune response and molecular mechanisms of immune evasion (2021) (24)
- Synthetic Lethality in Pancreatic Cancer: Discovery of a New RAD51-BRCA2 Small Molecule Disruptor That Inhibits Homologous Recombination and Synergizes with Olaparib (2020) (23)
- Synthesis, biological characterization and molecular modeling insights of spirochromanes as potent HDAC inhibitors. (2016) (23)
- Dual inhibition of mTOR pathway and VEGF signalling in neuroendocrine neoplasms: from bench to bedside. (2015) (23)
- PAT-ChIP coupled with laser microdissection allows the study of chromatin in selected cell populations from paraffin-embedded patient samples (2014) (21)
- Synthetic Lethality Triggered by Combining Olaparib with BRCA2-Rad51 Disruptors. (2017) (21)
- Leukemia-Associated Fusion Proteins: Multiple Mechanisms of Action to Drive Cell Transformation (2005) (21)
- A redundant oncogenic potential of the retinoic receptor (RAR) alpha, beta and gamma isoforms in acute promyelocytic leukemia. (2007) (20)
- Metal binding sites of the estradiol receptor from calf uterus and their possible role in the regulation of receptor function. (1989) (20)
- Altered epigenetic signals in human disease (2004) (20)
- Quantitative increases in DNA binding affinity and positional effects determine 9-cis retinoic acid induced activation of the retinoid X receptorβ homodimer (1994) (19)
- Pyrrole- and indole-containing tranylcypromine derivatives as novel lysine-specific demethylase 1 inhibitors active on cancer cells (2015) (19)
- Self-renewal of tumor cells: epigenetic determinants of the cancer stem cell phenotype. (2016) (19)
- PML is required for telomere stability in non-neoplastic human cells (2015) (18)
- Erratum: miR-194-5p/BCLAF1 deregulation in AML tumorigenesis (2017) (18)
- A redundant oncogenic potential of the retinoic receptor (RAR) α, β and γ isoforms in acute promyelocytic leukemia (2007) (18)
- HDAC3 activity is required for initiation of leukemogenesis in acute promyelocytic leukemia (2017) (17)
- From Resistance to Sensitivity: Insights and Implications of Biphasic Modulation of Autophagy by Sunitinib (2017) (17)
- Tuning mTORC1 activity dictates the response of acute myeloid leukemia to LSD1 inhibition (2019) (17)
- Phosphorylation of SOS1 on tyrosine 1196 promotes its RAC GEF activity and contributes to BCR-ABL leukemogenesis (2017) (17)
- Pure Diastereomers of a Tranylcypromine-Based LSD1 Inhibitor: Enzyme Selectivity and In-Cell Studies. (2015) (16)
- Identification of a Novel cis-Element Required for the Constitutive Activity and Osmotic Response of the Rat Aldose Reductase Promoter* (1997) (16)
- Redundant function of retinoic acid receptor isoforms in leukemogenesis unravels a prominent function of genome topology and architecture in the selection of mutagenic events in cancer (2009) (16)
- Pharmacokinetic drug evaluation of ribociclib for the treatment of metastatic, hormone-positive breast cancer (2017) (15)
- Tranylcypromine‐Based LSD1 Inhibitors: Structure‐Activity Relationships, Antiproliferative Effects in Leukemia, and Gene Target Modulation (2020) (15)
- A novel autophagy-independent, oncosuppressive function of BECN1: Degradation of MCL1 (2015) (15)
- Long non‐coding RNA TINCR suppresses metastatic melanoma dissemination by preventing ATF4 translation (2021) (15)
- Targeting protein inactivation through an oligomerization chain reaction (2002) (15)
- Eosinophilic crystals as a distinctive morphologic feature of a hyaline droplet nephropathy in a mouse model of acute myelogenous leukaemia. (2003) (15)
- Differentiation response of acute promyelocytic leukemia cells and PML/RARα leukemogenic activity studies by real-time RT-PCR (2005) (14)
- Fish the ChIPs: a pipeline for automated genomic annotation of ChIP-Seq data (2011) (13)
- Redox-Mediated Suberoylanilide Hydroxamic Acid Sensitivity in Breast Cancer. (2015) (13)
- Quantitative Chemical Proteomics Identifies Novel Targets of the Anti-cancer Multi-kinase Inhibitor E-3810* (2014) (13)
- Synthesis and Biological Characterization of Amidopropenyl Hydroxamates as HDAC Inhibitors (2010) (13)
- Synthesis and biological characterization of spiro[2H-(1,3)-benzoxazine-2,4'-piperidine] based histone deacetylase inhibitors. (2013) (12)
- Retinoid receptor-induced alteration of the chromatin assembled on a ligand-responsive promoter in Xenopus oocytes. (1998) (12)
- Epigenomic profiling of archived FFPE tissues by enhanced PAT-ChIP (EPAT-ChIP) technology (2018) (12)
- Proteolytic activity of the purified hormone-binding subunit in the estrogen receptor. (1991) (11)
- Diagnosis of vascular diseases. Ultrasound investigations - guidelines of the italian society for vascular investigation. (2012) (11)
- Discovery of Reversible Inhibitors of KDM1A Efficacious in Acute Myeloid Leukemia Models. (2020) (11)
- Activation of Protein Kinase C-( PKC-) by All-trans-retinoic Acid (2003) (10)
- Spiro[chromane‐2,4′‐piperidine]‐Based Histone Deacetylase Inhibitors with Improved in vivo Activity (2012) (10)
- Single cell-derived spheroids capture the self-renewing subpopulations of metastatic ovarian cancer (2018) (10)
- T cell activation and increases in protein kinase C activity enhance retinoic acid-induced gene transcription. (1994) (9)
- Involvement of Heparanase in Tumor Progression and Normal Differentiation (2003) (9)
- Determinants of oncogenic transformation in acute promyelocytic leukemia: the hetero-union makes the force. (2007) (9)
- Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models. (2022) (9)
- The APL-associated fusion proteins. (1999) (9)
- The Role of Chromatin-Associated Proteins in Cancer (2017) (9)
- HDAC Inhibition as Potential Therapeutic Strategy to Restore the Deregulated Immune Response in Severe COVID-19 (2022) (8)
- Leukomogenic factors downregulate heparanase expression in acute myeloid leukemia cells. (2005) (8)
- Differential 9-cis-Retinoic Acid-dependent Transcriptional Activation by Murine Retinoid X Receptor (RXR) and RXR (1996) (8)
- Pharmacological inhibition of LSD1 triggers myeloid differentiation by targeting GSE1 oncogenic functions in AML (2021) (7)
- Semantic and Geographical Analysis of COVID-19 Trials Reveals a Fragmented Clinical Research Landscape Likely to Impair Informativeness (2020) (7)
- Sex and cancer immunotherapy: Current understanding and challenges. (2022) (7)
- Differential 9-cis-retinoic acid-dependent transcriptional activation by murine retinoid X receptor alpha (RXR alpha) and RXR beta. Role of cell type and RXR domains. (1996) (7)
- Shc-generated Oxidative Signal Promotes Fat Accumulation * (2008) (6)
- CDK12 promotes tumorigenesis but induces vulnerability to therapies inhibiting folate one-carbon metabolism in breast cancer (2022) (6)
- MicroRNA-222 Regulates Melanoma Plasticity (2020) (6)
- Mass-spectrometry analysis of histone post-translational modifications in pathology tissue using the PAT-H-MS approach (2016) (6)
- An aprotinin binding site localized in the hormone binding domain of the estrogen receptor from calf uterus. (1990) (6)
- Erratum: PML is required for telomere stability in non-neoplastic human cells (2016) (6)
- Comparing apples with oranges: studying LSD1 inhibitors in cellular assays. (2019) (5)
- SMARCA5 interacts with NUP98-NSD1 oncofusion protein and sustains hematopoietic cells transformation (2022) (5)
- Preclinical models of breast cancer: Two-way shuttles for immune checkpoint inhibitors from and to patient bedside. (2019) (5)
- G1 Cell-Cycle Arrest and Apoptosis by Histone Deacetylase Inhibition in MLL-AF9 Acute Myeloid Leukemia Cells Is MLL-AF9 Independent. (2005) (5)
- Semantic and geographical analysis of Covid-19 trials reveals a fragmented clinical research landscape likely to impair informativeness. (2020) (5)
- LSD1-directed therapy affects glioblastoma tumorigenicity by deregulating the protective ATF4-dependent integrated stress response (2021) (5)
- Chiral Resolution and Pharmacological Characterization of the Enantiomers of the Hsp90 Inhibitor 2‐Amino‐7‐[4‐fluoro‐2‐(3‐pyridyl)phenyl]‐4‐methyl‐7,8‐dihydro‐6H‐quinazolin‐5‐one Oxime (2014) (4)
- Immunocell-array for Molecular Dissection of Multiple Signaling Pathways in Mammalian Cells*S (2007) (4)
- Discovery of a Benzimidazole-based Dual FLT3/TrKA Inhibitor Targeting Acute Myeloid Leukemia (2021) (4)
- Immunohistochemical Detection of Yml/Ym2 Chitinase-like Lectins Associated with Hyalinosis and Polypoid Adenomas of the Transitional Epithelium in a Mouse with Acute Myeloid Leukemia (2006) (4)
- Endosomal trafficking and DNA damage checkpoint kinases dictate survival to replication stress by regulating amino acid uptake and protein synthesis. (2021) (3)
- Valproic Acid Plus Retinoic Acid Induce Myeloid Differentiation in Chemotherapy-Resistant Acute Myeloid Leukemia Patients. (2004) (3)
- Aprotinin inhibits the hormone binding of the estrogen receptor from calf uterus. (1989) (3)
- Novel potent inhibitors of the histone demethylase KDM1A (LSD1), orally active in a murine promyelocitic leukemia model. (2017) (3)
- Indolin-2-one derivatives as selective Aurora B kinase inhibitors targeting breast cancer. (2021) (3)
- Involvement of the Histone Deacetylase SIRT1 in COUP-TF-interacting Protein 2-mediated Transcriptional Repression (2003) (3)
- Tackling oxidative stress by a direct route: a new job for HDAC inhibitors? (2015) (2)
- Endocrine resistance and breast cancer plasticity are controlled by CoREST (2022) (2)
- Longitudinal single-cell transcriptomics reveals distinct patterns of recurrence in acute myeloid leukemia (2022) (2)
- Co-targeting leukemia-initiating cells and leukemia bulk leads to disease eradication (2022) (2)
- Anticancer innovative therapy congress: Highlights from the 10th anniversary edition. (2021) (2)
- Insights into the design of inhibitors of the EGFR family with anticancer activity overcoming resistance: a case of optimizing thieno[2,3-d]pyrimidine-based EGFR inhibitors (2022) (2)
- DNA binding modes of leukemia oncoproteins. (2016) (2)
- In vivo temporal resolution of acute promyelocytic leukemia progression reveals a role of Klf4 in suppressing early leukemic transformation (2022) (1)
- Corrigendum: From Resistance to Sensitivity: Insights and Implications of Biphasic Modulation of Autophagy by Sunitinib (2018) (1)
- PAT-ChIP coupled with laser microdissection allows the study of chromatin in selected cell populations from paraffin-embedded patient samples (2014) (1)
- Gene regulation of aldose reductase under osmotic stress. (1997) (1)
- [Primary hyperaldosteronism due to adrenocortical carcinoma. A clinical case report]. (1986) (1)
- Assessment of Histone Acetylation Levels in Relation to Cell Cycle Phase (2008) (1)
- Mass-spectrometry analysis of histone post-translational modi fi cations in pathology tissue using the PAT-HMS approach (2016) (1)
- Discovery of EMD37, a 1,2,4-oxadiazole derivative, as a novel endoplasmic reticulum stress inducer with potent anticancer activity. (2022) (0)
- LSD1(KDM1A)-CoREST in complex with 1-Phenyl-Tranylcypromine (2014) (0)
- Activation of the p 70 S 6 kinase by all-trans-retinoic acid in acute promyelocytic leukemia cells (2004) (0)
- Abstract A28: Challenging new epigenetic vulnerabilities in human metastatic melanoma PDXs (2016) (0)
- P04.84 Lysine-specific histone demethylase 1 (LSD1) contributes to the maintenance of Glioblastoma stem cell population (2018) (0)
- Author Correction: Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion (2019) (0)
- Inhibiting LSD1 suppresses coronavirus-induced inflammation but spares innate antiviral activity (2021) (0)
- Document Guidelines for the surveillance of patients with stents (2012) (0)
- Shiftworking keeps locked-down lab on track (2020) (0)
- Abstract 2452: Metformin administration in hypoglycemia compromises cancer cell viability in glioblastoma initiating cells (2021) (0)
- Improved outcomes in women with BRAF-mutant melanoma treated with BRAF/MEK-targeted therapy across randomized clinical trials. A systematic review and meta-analysis. (2022) (0)
- Prognostic and predictive role of fumarate hydratase in metastatic clear cell renal cell carcinoma. (2018) (0)
- Phase II study with histone deacetylase (HDAC) inhibitor Valproic acid (VPA) in patients with advanced melanoma (2004) (0)
- Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis (2017) (0)
- LSD1(KDM1A)-CoREST in complex with 1-Benzyl-Tranylcypromine (2014) (0)
- , V gene expression . its ligand and enhances retinoid-dependent RXR-retinoic acid receptor heterodimer binds Retinoid X receptor ( RXR ) within the (1997) (0)
- Molecular Pathways Molecular Pathways : Old Drugs De fi ne New Pathways : Non-Histone Acetylation at the Crossroads of the DNA Damage Response and Autophagy (2012) (0)
- Phenyl-substituted maleimide as medicaments for the inhibition of degenerative tissue damage by inhibiting mpt (2007) (0)
- [Use of computerized tomography as a guide in thoracic needle biopsies]. (1987) (0)
- Abstract 903: Metformin antitumoral activity is exclusively mediated by the membrane functional expression of the Chloride Intracellular Channel 1 in glioblastoma stem cells (2022) (0)
- SMARCA5 interacts with NUP98-NSD1 oncofusion protein and sustains hematopoietic cells transformation (2022) (0)
- Crystal structure of LSD1-CoREST in complex with a tranylcypromine derivative (MC2580, 14e) (2010) (0)
- Successful Healing of Hydroxyurea-Related Leg Ulcers With Topical Granulocyte-Macrophage Colony-Stimulating Factor (2017) (0)
- International International Angiology Angiology (2012) (0)
- Document Guidelines for the assessment of the visceral arteries and veins and of the renal artery (2012) (0)
- Design, Synthesis and Biological Evaluation of A Boron Containing Retinoid As a Novel Therapeutic Agent for Acute Promyelocytic Leukemia (2011) (0)
- Valproic acid to treat breast cancer, colon cancer, head and neck cancer, small cell lung cancer and blood cell cancer in combination with radiation (2002) (0)
- Advances in Brief Histone Deacetylase-targeted Treatment Restores Retinoic Acid Signaling and Differentiation in Acute Myeloid Leukemia 1 (2000) (0)
- Epigenomic profiling of archived FFPE tissues by enhanced PAT-ChIP (EPAT-ChIP) technology (2018) (0)
- New reversible inhibitors of histone lysine demethylase (KDM1A/LSD1). From high throughput screening to the identification of low nanomolar inhibitors with cellular activity (2016) (0)
- Corrigendum: Acquired CYP19A1 amplification is an early specific mechanism of aromatase inhibitor resistance in ERα metastatic breast cancer (2017) (0)
- Document Guidelines for the assessment of diagnosis of superficial vein thrombosis and diagnosis of deep vein thrombosis (2012) (0)
- Preview : Published ahead of advance online publication HDAC 3 activity is required for initiation of leukemogenesis in acute promyelocytic leukemia (2017) (0)
- A Refined Single Cell Landscape of Haematopoiesis in the Mouse Foetal Liver (2023) (0)
- Document Guidelines for the assessment of the circulation of the upper limbs and of the thoracic outlet syndrome (2012) (0)
- Crystal structure of LSD1-CoREST in complex with (+)-trans-2- phenylcyclopropyl-1-amine (2010) (0)
- Longitudinal single-cell transcriptomics reveals distinct patterns of recurrence in acute myeloid leukemia (2022) (0)
- Crystal structure of LSD1-CoREST in complex with para-bromo-(-)-trans- 2-phenylcyclopropyl-1-amine (2010) (0)
- The Value of Nonionic Contrast Media in CT (1982) (0)
- Drosophila F elements are transcribed by an internal RNA polymerase II promoter (1990) (0)
- [Obstructive syndrome of the superior vena cava caused by bronchogenic cyst. A clinical case]. (1987) (0)
- 571 Novel potent inhibitors of the Histone Demethylase KDM1A: Synthesis, pharmacological evaluation and in vivo activity (2014) (0)
- 114 Chromatin modulates DNA damage response activation in oncogene-expressing cells (2009) (0)
- Characterization of a novel KDM1A/LSD1 inhibitor DDP_38003 in preclinical models of human and murine acute myeloid leukemia (2016) (0)
- valproic for breast cancer management, colon cancer, head and neck cancer, small cell carcinoma of lung and leukemia, in combination with radiotherapy acid. (2002) (0)
- p66 Shc -generatedOxidativeSignalPromotesFatAccumulation * □ (2008) (0)
- Document Guidelines for the assessment of the arterial circulation of the lower limbs (2012) (0)
- Derives de tranylcypromine comme inhibiteurs de l'histone demethylase lsd1 et/ou lsd2 (2011) (0)
- Fumarate hydratase expression in localized, radically-resected clear cell renal cell carcinoma and its association with clinical outcomes. (2019) (0)
- Cluster assembled nanostructured TiO2 film mediates efficient and safe retroviral gene transduction in primary adult human melanocytes for ex-vivo gene therapy (2006) (0)
- Inhibition of the Histone Demethylase LSD1 Combined with Caloric Restriction or IGF1/Insulin Inhibition Leads to Durable Responses in a Preclinical Model of Acute Myeloid Leukemia (2015) (0)
- Pharmacological inhibition of LSD1 triggers myeloid differentiation by targeting GSE1, a novel oncogene in AML (2021) (0)
- Activation of Protein Kinase C- (cid:71) (PKC- (cid:71) ) by All- trans -retinoic Acid (2003) (0)
- Polypoid Adenomas of the Transitional Epithelium in a Mouse with Acute Myeloid Leukemia Immunohistochemical Detection of Yml/Ym2 Chitinase-like Lectins Associated with Hyalinosis and (2013) (0)
- Document Guidelines for the surveillance of patients with prosthesis or aortic-iliac-femoral endograft (2012) (0)
- Valproic acid for the treatment of breast cancer, cardiac cancer, head and neck cancer, small cellular lung carcinoma and blood cell cancer in combination with irradiation (2002) (0)
- Document Guidelines for the assessment of the aorta and iliac arteries (2012) (0)
- Acid Receptor Retinoids Induce Fibroblast Growth Factor-2 Production in Endothelial Cells via Retinoic (2001) (0)
- Metformin antiproliferative activity is exclusively mediated by the membrane functional expression of the Chloride Intracellular Channel 1 in glioblastoma stem cells (2022) (0)
- Oncogenicdisruption of promyelocytic leukemia nuclear bodies results in defective DNA double strand breakssensing and repair (2014) (0)
- Document Guidelines for the assessment of the intracranial circulation (2012) (0)
- LSD1(KDM1A)-CoREST in complex with 1-Methyl-Tranylcypromine (1R,2S) (2014) (0)
- Topical use of valproic acid for the treatment of psoriasis and acne (2004) (0)
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What Schools Are Affiliated With Saverio Minucci?
Saverio Minucci is affiliated with the following schools:
