Scott A. Armstrong
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American pediatric oncologist and cancer biologist
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Why Is Scott A. Armstrong Influential?
(Suggest an Edit or Addition)According to Wikipedia, Scott Allen Armstrong is an American pediatric oncologist and cancer biologist focused on chromatin-based control of gene expression in cancer and therapeutic discovery. Armstrong and his team were the first to isolate rare leukemia stem cells in a mouse model of leukemia.
Scott A. Armstrong's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease (2006) (4224)
- FoxOs Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress (2007) (1564)
- MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia (2002) (1509)
- Transformation from committed progenitor to leukaemia stem cell initiated by MLL–AF9 (2006) (1433)
- Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members. (2006) (1204)
- MLL translocations, histone modifications and leukaemia stem-cell development (2007) (1137)
- High-throughput oncogene mutation profiling in human cancer (2007) (1041)
- Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor. (2011) (859)
- MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L. (2011) (787)
- The Wnt/β-Catenin Pathway Is Required for the Development of Leukemia Stem Cells in AML (2010) (732)
- Chromatin modifying enzymes as modulators of reprogramming (2012) (621)
- H3K79 methylation profiles define murine and human MLL-AF4 leukemias. (2008) (534)
- Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance. (2006) (501)
- Defective forebrain development in mice lacking gp330/megalin. (1996) (498)
- Molecular genetics of acute lymphoblastic leukemia. (2005) (437)
- Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification. (2003) (417)
- The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia. (2005) (377)
- Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation. (2003) (350)
- Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies (2014) (320)
- Cytogenetics for the model system Arabidopsis thaliana. (1998) (316)
- cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort protein (1993) (314)
- HOXA9 is required for survival in human MLL-rearranged acute leukemias. (2009) (310)
- Acute myelogenous leukemia-induced sympathetic neuropathy promotes malignancy in an altered hematopoietic stem cell niche. (2014) (284)
- Loss of BAP1 function leads to EZH2-dependent transformation (2015) (275)
- Mediator Kinase Inhibition Further Activates Super-Enhancer Associated Genes in AML (2015) (274)
- Functional expression of low density lipoprotein receptor-related protein is controlled by receptor-associated protein in vivo. (1995) (266)
- FLT3 mutations in childhood acute lymphoblastic leukemia. (2004) (256)
- AKT/FOXO Signaling Enforces Reversible Differentiation Blockade in Myeloid Leukemias (2011) (251)
- The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia. (2018) (245)
- Genetic and pharmacologic inhibition of β-catenin targets imatinib-resistant leukemia stem cells in CML. (2012) (236)
- Genomic and functional analysis of leukemic transformation of myeloproliferative neoplasms (2014) (229)
- Polycomb repressive complex 2 is required for MLL-AF9 leukemia (2012) (214)
- Integrated genomic DNA/RNA profiling of hematologic malignancies in the clinical setting. (2016) (209)
- BCL-2 dependence and ABT-737 sensitivity in acute lymphoblastic leukemia. (2008) (202)
- PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D (2017) (198)
- A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies (2019) (195)
- Differential mRNA expression of Ara-C-metabolizing enzymes explains Ara-C sensitivity in MLL gene-rearranged infant acute lymphoblastic leukemia. (2003) (194)
- DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling (2016) (186)
- DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia (2015) (183)
- Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands. (2017) (180)
- Modulation of splicing catalysis for therapeutic targeting of leukemias with spliceosomal mutations (2016) (179)
- Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis. (2009) (178)
- Mutations in epigenetic regulators including SETD2 are gained during relapse in pediatric acute lymphoblastic leukemia (2014) (174)
- Cell of origin determines clinically relevant subtypes of MLL-rearranged AML (2013) (173)
- CAAX Geranylgeranyl Transferase Transfers Farnesyl as Efficiently as Geranylgeranyl to RhoB (*) (1995) (173)
- DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier (2014) (169)
- REP-2, a Rab escort protein encoded by the choroideremia-like gene. (1994) (165)
- Targeting FLT3 in primary MLL-gene-rearranged infant acute lymphoblastic leukemia. (2005) (165)
- mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis. (2012) (164)
- A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia. (2019) (163)
- Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies (2014) (161)
- Notch pathway activation targets AML-initiating cell homeostasis and differentiation (2013) (156)
- Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l. (2013) (156)
- Differential niche and Wnt requirements during acute myeloid leukemia progression. (2011) (154)
- In Vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling. (2013) (152)
- CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma (2014) (150)
- AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes. (2014) (142)
- Requirement for CDK6 in MLL-rearranged acute myeloid leukemia. (2013) (141)
- Nonidentical subunits of p21H-ras farnesyltransferase. Peptide binding and farnesyl pyrophosphate carrier functions. (1991) (137)
- ENL links histone acetylation to oncogenic gene expression in AML (2017) (137)
- Depletion of Jak2V617F myeloproliferative neoplasm-propagating stem cells by interferon-α in a murine model of polycythemia vera. (2013) (137)
- Myeloid progenitor cluster formation drives emergency and leukemic myelopoiesis (2017) (131)
- A UTX-MLL4-p300 Transcriptional Regulatory Network Coordinately Shapes Active Enhancer Landscapes for Eliciting Transcription. (2017) (127)
- Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia. (2016) (123)
- MLL-AF9 and FLT3 cooperation in acute myelogenous leukemia: development of a model for rapid therapeutic assessment (2008) (122)
- Exploiting the Epigenome to Control Cancer-Promoting Gene-Expression Programs. (2016) (121)
- Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains. (2012) (120)
- Conditional MLL‐CBP targets GMP and models therapy‐related myeloproliferative disease (2005) (114)
- miR-128b is a potent glucocorticoid sensitizer in MLL-AF4 acute lymphocytic leukemia cells and exerts cooperative effects with miR-221. (2008) (103)
- Therapeutic targeting of preleukemia cells in a mouse model of NPM1 mutant acute myeloid leukemia (2020) (102)
- Abrogation of MLL–AF10 and CALM–AF10-mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l (2013) (101)
- Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma (2018) (101)
- Targeting epigenetic programs in MLL-rearranged leukemias. (2011) (100)
- Genomewide identification of prednisolone-responsive genes in acute lymphoblastic leukemia cells. (2005) (98)
- Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyond. (2015) (96)
- Hematopoietic Differentiation Is Required for Initiation of Acute Myeloid Leukemia. (2015) (91)
- NUP98 Fusion Proteins Interact with the NSL and MLL1 Complexes to Drive Leukemogenesis. (2016) (86)
- SETD2 alterations impair DNA damage recognition and lead to resistance to chemotherapy in leukemia. (2017) (85)
- A novel mutation in the miR-128b gene reduces miRNA processing and leads to glucocorticoid resistance of MLL-AF4 Acute Lymphocytic Leukemia cells (2010) (82)
- Deletion of ribosomal protein genes is a common vulnerability in human cancer, especially in concert with TP53 mutations (2017) (80)
- MLL-rearranged leukemias: insights from gene expression profiling. (2003) (79)
- Association of high-level MCL-1 expression with in vitro and in vivo prednisone resistance in MLL-rearranged infant acute lymphoblastic leukemia. (2010) (78)
- A Non-catalytic Function of SETD1A Regulates Cyclin K and the DNA Damage Response (2018) (77)
- HOXA9 Reprograms the Enhancer Landscape to Promote Leukemogenesis. (2018) (76)
- cDNA cloning and expression of the alpha and beta subunits of rat Rab geranylgeranyl transferase. (1993) (76)
- Targeting epigenetic regulators for cancer therapy (2014) (76)
- The PZP Domain of AF10 Senses Unmodified H3K27 to Regulate DOT1L-Mediated Methylation of H3K79. (2015) (75)
- LSD1 inhibition exerts its antileukemic effect by recommissioning PU.1- and C/EBPα-dependent enhancers in AML. (2018) (72)
- EVI1 is critical for the pathogenesis of a subset of MLL-AF9-rearranged AMLs. (2012) (71)
- Telomerase inhibition effectively targets mouse and human AML stem cells and delays relapse following chemotherapy. (2014) (71)
- Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells (2017) (69)
- JMJD1C is required for the survival of acute myeloid leukemia by functioning as a coactivator for key transcription factors (2015) (69)
- MLL-AF9- and HOXA9-mediated acute myeloid leukemia stem cell self-renewal requires JMJD1C. (2016) (68)
- Sequencing histone-modifying enzymes identifies UTX mutations in acute lymphoblastic leukemia (2012) (66)
- PGBD5 promotes site-specific oncogenic mutations in human tumors (2017) (64)
- Silencing of the tumor suppressor gene FHIT is highly characteristic for MLL gene rearranged infant acute lymphoblastic leukemia (2006) (63)
- Chromatin maps, histone modifications and leukemia (2009) (63)
- Recent progress toward epigenetic therapies: the example of mixed lineage leukemia. (2013) (63)
- The JAK 2 V 617 F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia , but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia (2005) (62)
- Peptidomimetic blockade of MYB in acute myeloid leukemia (2016) (60)
- Chromatin modifications as therapeutic targets in MLL-rearranged leukemia. (2012) (60)
- Common and overlapping oncogenic pathways contribute to the evolution of acute myeloid leukemias. (2011) (57)
- Final Report of Phase 1 Study of the DOT1L Inhibitor, Pinometostat (EPZ-5676), in Children with Relapsed or Refractory MLL-r Acute Leukemia (2016) (56)
- Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL-rearranged AML (2016) (55)
- Amplification of AML1 in childhood acute lymphoblastic leukemias (2001) (53)
- Ezh2 Controls an Early Hematopoietic Program and Growth and Survival Signaling in Early T Cell Precursor Acute Lymphoblastic Leukemia (2016) (53)
- IKZF2 Drives Leukemia Stem Cell Self-Renewal and Inhibits Myeloid Differentiation. (2019) (53)
- Patient-derived xenotransplants can recapitulate the genetic driver landscape of acute leukemias (2016) (52)
- Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis. (2008) (52)
- A Phase 1 Study of the DOT1L Inhibitor, Pinometostat (EPZ-5676), in Adults with Relapsed or Refractory Leukemia: Safety, Clinical Activity, Exposure and Target Inhibition (2015) (51)
- A role for DOT1L in MLL-rearranged leukemias. (2011) (50)
- Leukemia stem cells and human acute lymphoblastic leukemia. (2009) (50)
- Drugging Chromatin in Cancer: Recent Advances and Novel Approaches. (2015) (50)
- Selective Inhibition of HDAC1 and HDAC2 as a Potential Therapeutic Option for B-ALL (2015) (49)
- MLL partial tandem duplication leukemia cells are sensitive to small molecule DOT1L inhibition (2015) (49)
- MEF2C Phosphorylation Is Required for Chemotherapy Resistance in Acute Myeloid Leukemia. (2018) (47)
- Mixed-Lineage Leukemia Fusions and Chromatin in Leukemia. (2017) (46)
- Synergistic Targeting of FLT3 Mutations in AML via Combined Menin-MLL and FLT3 Inhibition. (2020) (45)
- Self-renewal related signaling in myeloid leukemia stem cells (2011) (44)
- The cell fate determinant Llgl1 influences HSC fitness and prognosis in AML (2013) (44)
- NCI first International Workshop on the biology, prevention, and treatment of relapse after allogeneic hematopoietic stem cell transplantation: report from the committee on the biological considerations of hematological relapse following allogeneic stem cell transplantation unrelated to graft-versus (2010) (43)
- The DOT1L Inhibitor EPZ-5676: Safety and Activity in Relapsed/Refractory Patients with MLL-Rearranged Leukemia (2014) (43)
- Targeting chromatin complexes in fusion protein-driven malignancies (2019) (42)
- Crebbp haploinsufficiency in mice alters the bone marrow microenvironment, leading to loss of stem cells and excessive myelopoiesis. (2011) (41)
- The role of DOT1L in the maintenance of leukemia gene expression. (2016) (40)
- The active site of membrane-bound meizothrombin. A fluorescence determination of its distance from the phospholipid surface and its conformational sensitivity to calcium and factor Va. (1990) (40)
- MLL-Rearranged B Lymphoblastic Leukemias Selectively Express the Immunoregulatory Carbohydrate-Binding Protein Galectin-1 (2010) (39)
- A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence (2015) (34)
- Transformation from Committed Progenitor to Leukemia Stem Cells (2009) (34)
- Impact of FLT3-ITD location on sensitivity to TKI-therapy in vitro and in vivo (2016) (34)
- DOT1L-Mediated H3K79 Methylation in Chromatin Is Dispensable for Wnt Pathway-Specific and Other Intestinal Epithelial Functions (2013) (34)
- Linking miRNA regulation to BCR-ABL expression: the next dimension. (2008) (34)
- The clathrin-binding domain of CALM and the OM-LZ domain of AF10 are sufficient to induce acute myeloid leukemia in mice (2011) (33)
- AACR Cancer Progress Report 2016 (2016) (32)
- Histone Acetyltransferase Activity of MOF Is Required for MLL-AF9 Leukemogenesis. (2017) (31)
- The Stem Cell Discovery Engine: an integrated repository and analysis system for cancer stem cell comparisons (2011) (30)
- Tumor-specific HSP90 inhibition as a therapeutic approach in JAK-mutant acute lymphoblastic leukemias. (2015) (30)
- FLT 3 mutations in childhood acute lymphoblastic leukemia (2004) (30)
- MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia. (2016) (30)
- Histone acetyltransferase activity of MOF is required for adult but not early fetal hematopoiesis in mice. (2017) (29)
- Genome-wide SNP analysis in cancer: leukemia shows the way. (2007) (29)
- miR-99 regulates normal and malignant hematopoietic stem cell self-renewal (2017) (29)
- Preparation of recombinant Rab geranylgeranyltransferase and Rab escort proteins. (1995) (29)
- Inhibition Of LSD1 As a Therapeutic Strategy For The Treatment Of Acute Myeloid Leukemia (2013) (29)
- Cancer: inappropriate expression of stem cell programs? (2008) (28)
- Abrogation of MLL-AF10 and CALM-AF10 Mediated Transformation Through Genetic Inactivation or Pharmacological Inhibition of the H3K79 Methyltransferase DOT1L. (2012) (28)
- Therapeutic Implications of Leukemia Stem Cell Development (2007) (27)
- Gene Expression Profiling Identifies BAX-δ as a Novel Tumor Antigen in Acute Lymphoblastic Leukemia (2005) (25)
- Resistance mechanisms to SYK inhibition in acute myeloid leukemia. (2019) (25)
- HELP for AML: methylation profiling opens new avenues. (2010) (23)
- Discovery and Characterization of a Peptoid with Antifungal Activity against Cryptococcus neoformans. (2016) (23)
- FLT3 as a therapeutic target in childhood acute leukemia. (2007) (22)
- Inactivation of Eed impedes MLL-AF9-mediated leukemogenesis through Cdkn2a-dependent and Cdkn2a-independent mechanisms in a murine model. (2015) (21)
- 212 Novel anti-tumor activity of targeted LSD1 inhibition by GSK2879552 (2014) (20)
- Designed to kill: novel menin-MLL inhibitors target MLL-rearranged leukemia. (2015) (20)
- Novel Inhibitors of the Histone-Methyltransferase DOT1L Show Potent Antileukemic Activity in Patient-derived Xenografts. (2020) (20)
- Gastrointestinal stromal tumor enhancers support a transcription factor network predictive of clinical outcome (2018) (20)
- Evolutionarily Conserved Signaling Pathways: Acting in the Shadows of Acute Myelogenous Leukemia's Genetic Diversity (2015) (20)
- Oncogenic Gene-Expression Programs in Leiomyosarcoma and Characterization of Conventional, Inflammatory, and Uterogenic Subtypes (2020) (19)
- Microarrays to identify new therapeutic strategies for cancer. (2007) (18)
- Gene expression profiling identifies BAX-delta as a novel tumor antigen in acute lymphoblastic leukemia. (2005) (18)
- DNA methylation profiling in acute myeloid leukemia: from recent technological advances to biological and clinical insights. (2010) (18)
- Structure-Guided DOT1L Probe Optimization by Label-Free Ligand Displacement (2014) (17)
- Leukemia cell of origin influences apoptotic priming and sensitivity to LSD1 inhibition (2020) (17)
- Genetics, epigenetics, and leukemia. (2010) (17)
- Cancer: The flipside of Notch (2011) (17)
- Transmembrane Inhibitor of RICTOR/mTORC2 in Hematopoietic Progenitors (2014) (17)
- Rearranged Infant Acute Lymphoblastic Leukemia. (2008) (15)
- Erratum: Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins (2016) (15)
- Targeting FLT 3 in primary MLL-gene – rearranged infant acute lymphoblastic leukemia (2005) (15)
- Enhancer Domains in Gastrointestinal Stromal Tumor Regulate KIT Expression and Are Targetable by BET Bromodomain Inhibition. (2019) (14)
- Rationale for targeting BCL6 in MLL-rearranged acute lymphoblastic leukemia (2019) (14)
- Paediatric Strategy Forum for medicinal product development of epigenetic modifiers for children: ACCELERATE in collaboration with the European Medicines Agency with participation of the Food and Drug Administration. (2020) (14)
- Pathprinting: An integrative approach to understand the functional basis of disease (2013) (14)
- Mixed lineage leukemia translocations and a leukemia stem cell program. (2007) (13)
- Preliminary Report of the Phase 1 Study of the DOT1L Inhibitor, Pinometostat, EPZ-5676, in Children with Relapsed or Refractory MLL-r Acute Leukemia: Safety, Exposure and Target Inhibition (2015) (13)
- Cancer stem cells in hematopoietic malignancies. (2008) (13)
- Targeting Chromatin Complexes in Myeloid Malignancies and Beyond: From Basic Mechanisms to Clinical Innovation (2020) (12)
- Haploinsufficiency of Dnmt1 Impairs Leukemia Stem Cell Function Through Derepression of Bivalent Chromatin Domains (2011) (12)
- Distinctive IGH gene segment usage and minimal residual disease detection in infant acute lymphoblastic leukaemias (2005) (12)
- Cancer Stem Cells in Hematopoietic Malignancies. (2008) (12)
- iCanPlot: Visual Exploration of High-Throughput Omics Data Using Interactive Canvas Plotting (2012) (12)
- High-resolution characterization of gene function using single-cell CRISPR tiling screen (2021) (12)
- Genomic approaches to the pathogenesis and treatment of acute lymphoblastic leukemias (2002) (11)
- The menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML (2021) (11)
- Menin Inhibitors in Acute Myeloid Leukemia—What Does the Future Hold? (2022) (11)
- Forward genetic screen of human transposase genomic rearrangements (2016) (11)
- Controlled stem cell amplification by HOXB4 depends on its unique proline-rich region near the N terminus. (2017) (11)
- Global Increase in H3K79 Dimethylation in Murine and Human MLL-AF4 Lymphoblastic Leukemias. (2007) (10)
- Improved potency and reduced toxicity of the antifungal peptoid AEC5 through submonomer modification. (2018) (10)
- Chromatin Complexes Maintain Self-Renewal of Myeloid Progenitors in AML: Opportunities for Therapeutic Intervention (2020) (9)
- MLL::AF9 degradation induces rapid changes in transcriptional elongation and subsequent loss of an active chromatin landscape. (2022) (9)
- Antigen presentation safeguards the integrity of the hematopoietic stem cell pool. (2022) (9)
- MLL-AF 9 – and HOXA 9-mediated acute myeloid leukemia stem cell self-renewal requires JMJD 1 C (2018) (9)
- HAND1 and BARX1 Act as Transcriptional and Anatomic Determinants of Malignancy in Gastrointestinal Stromal Tumor (2021) (9)
- Myeloid Leukemia Cells With MLL partial Tandem Duplication Are Sensitive To Pharmacological Inhibition Of The H3K79 Methyltransferase DOT1L (2013) (8)
- Inhibition of MEK and ATR is effective in a B-cell acute lymphoblastic leukemia model driven by Mll-Af4 and activated Ras. (2018) (8)
- MLL-Menin Inhibition Reverses Pre-Leukemic Progenitor Self-Renewal Induced By NPM1 Mutations and Prevents AML Development (2018) (8)
- Gene expression profiling of leukemia stem cells. (2009) (7)
- Erratum: High-throughput oncogene mutation profiling in human cancer (Nature Genetics (2007) 39, (347-351)) (2007) (7)
- Abstract 3513: Inhibition of LSD1 for the treatment of cancer (2015) (7)
- Erratum: Corrigendum: High-throughput oncogene mutation profiling in human cancer (2007) (7)
- Functional screen of MSI 2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells (2017) (7)
- YBX1 mediates translation of oncogenic transcripts to control cell competition in AML (2021) (7)
- Reply to "Uveal melanoma cells are resistant to EZH2 inhibition regardless of BAP1 status" (2016) (7)
- A Phase Ib/II Study of the Histone Methyltransferase Inhibitor Pinometostat in Combination with Azacitidine in Patients with 11q23-Rearranged Acute Myeloid Leukemia (2019) (7)
- Genomic dark matter sheds light on EVI1-driven leukemia. (2014) (6)
- A Molecular Switch between Mammalian MLL Complexes Dictates Response to Menin–MLL Inhibition (2022) (6)
- It's Not What You Say But How You Say It: Targeting RNA Methylation in AML. (2020) (5)
- Molecular transformation from committed progenitor to leukemia stem cell initiated by MLL-AF 9 (2006) (5)
- DOT1L and Histone H3 Lysine79 Methylation as a Therapeutic Target in Mixed Lineage Leukemia. (2009) (5)
- Loss of H3K36 Methyltransferase SETD2 Impairs V(D)J Recombination during Lymphoid Development (2020) (5)
- Selective Inhibition of HDAC 1 and HDAC 2 as a Potential Therapeutic Option for BALL Short title : BALLs are sensitive to an HDAC 1 / HDAC 2 inhibitor (2015) (5)
- Erratum: PGBD5 promotes site-specific oncogenic mutations in human tumors (2017) (5)
- Acute myeloid leukemia driven by the CALM-AF10 fusion gene is dependent on BMI1. (2019) (5)
- MEN1 mutations mediate clinical resistance to menin inhibition (2023) (5)
- Mtor Complex 1 Plays Critical Roles in Hematopoiesis and Pten-Loss-Evoked Leukemogenesis (2011) (5)
- eXframe: reusable framework for storage, analysis and visualization of genomics experiments (2011) (5)
- Acute Myeloid Leukemia Driven by the CALM-AF10 Fusion Gene is Dependent on BMI1 (2019) (5)
- Location, Location, Location: Mutant NPM1c Cytoplasmic Localization Is Required to Maintain Stem Cell Genes in AML. (2018) (4)
- Can One Cell Influence Cancer Heterogeneity? (2012) (4)
- MOZ and Menin-MLL Complexes are Complementary Regulators of Chromatin Association and Transcriptional Output in Gastrointestinal Stromal Tumor. (2022) (4)
- Bone marrow surveillance of pediatric cancer survivors identifies clones that predict therapy-related leukemia. (2022) (4)
- IKAROS and MENIN Coordinate Therapeutically Actionable Leukaemogenic Gene Expression in MLL-r Acute Myeloid Leukaemia (2022) (4)
- Histone PTM Crosstalk Stimulates Dot1 Methyltransferase Activity. (2021) (4)
- β-Catenin Determines Developmental Stage Specific Transformation by Hox Genes. (2009) (4)
- A Gene Expression Connectivity Map Identifies Rapamycin as a Glucocorticoid Resistance Reversal Agent in Lymphoblastic Leukemia. (2005) (4)
- The menin inhibitor revumenib in KMT2A-rearranged or NPM1-mutant leukaemia (2023) (4)
- In Vivo RNA Interference Screening Identifies a Leukemia-Specific Dependence on Integrin Beta 3 Signaling (2011) (3)
- A Pilot Trial of Rapamycin with Glucocorticoids In Children and Adults with Relapsed ALL (2010) (3)
- Identification Of Actionable Genomic Alterations In Hematologic Malignancies By a Clinical Next Generation Sequencing-Based Assay (2013) (3)
- AKT/FOXO Signaling Enforces Reversible Differentiation Blockade in Myeloid Leukemias (2011) (3)
- A JAK/STAT-Mediated Inflammatory Signaling Cascade Drives Oncogenesis In AF10-Rearranged AML (2020) (3)
- Demonstration of a Role for Dot1l In MLL-Rearranged Leukemia Using a Conditional Loss of Function Model (2010) (3)
- Selective Inhibition of HDAC1 and HDAC2 Is a Potential Therapeutic Option for B-All (2010) (3)
- Patient Derived Xenograft (PDX) Models Recapitulate the Genomic-Driver Composition of Acute Leukemia Samples (2014) (3)
- Human PGBD5 DNA transposase promotes site-specific oncogenic mutations in rhabdoid tumors (2017) (2)
- Chapter 64 – Pathobiology of Acute Lymphoblastic Leukemia (2018) (2)
- The Myocyte Enhancer Factor 2C ( MEF2C ) Is a Direct Transcriptional Target of HOXA9 and Mediates Leukemia Survival in Human Mixed-Lineage Leukemias. (2007) (2)
- SETD2 haploinsufficiency enhances germinal center-associated AICDA somatic hypermutation to drive B cell lymphomagenesis. (2022) (2)
- Genomic and Proteomic Profiling of AF10-Fusion Oncoproteins Reveal Mechanisms of Leukemogenesis and Actionable Targets (2018) (2)
- Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor (2010) (2)
- Defining leukemia stem cells in MLL-translocated leukemias: implications for novel therapeutic strategies. (2007) (2)
- HOXA9 Represses Bim Expression in MLL Rearranged Leukemia: Implications for Drug Therapy. (2007) (2)
- Mutant NPM1 directly regulates oncogenic transcription in acute myeloid leukemia. (2022) (2)
- Targeting MYC-Driven B-Cell Lymphoma By Inhibition of the Histone Methyltransferase DOT1L (2018) (2)
- Patient Derived Xenograft (PDX) Models Faithfully Recapitulate The Genetic Composition Of Primary AML (2013) (2)
- Identification Of BCL6 As a Therapeutic Target In MLL-Rearranged ALL (2013) (1)
- MEF2C phosphorylation is required for chemotherapy resistance in acute myeloid leukemia (2017) (1)
- MLL Rearranged Infant Acute Lymphoblastic Leukemia Is Characterized by Silencing of the Putative Tumor Suppressor Gene FHIT. (2004) (1)
- Bio-Macromolecular Liquid Chromatography Yesterday and Today: Advancements in the Separation and Study of Nucleic Acids and Their Related Proteins (1989) (1)
- Epithelial Functions Pathway-Specific and Other Intestinal Chromatin Is Dispensable for Wnt DOT 1 L-Mediated H 3 K 79 Methylation in (2013) (1)
- Abstract 885: Epigenetic regulation of estrogen receptor transcription by the PI3K pathway in breast cancer (2016) (1)
- Taspase1 orchestrates fetal liver hematopoietic stem cell and vertebrae fates by cleaving TFIIA (2021) (1)
- SETD2 Heterozygous Loss in Leukemia Leads to Chemotherapy Resistance through Attenuation of the DNA Damage Response (2015) (1)
- HoxA9 Knockdown Inhibits Proliferation and Induces Cell Death in Human MLL-Rearranged Leukemias. (2006) (1)
- Regulation Of Normal and Malignant Hoxa Gene Expression Through Higher H3K79 Methylated States (2013) (1)
- β-Catenin Suppression Targets Imatinib Resistant Leukemia Stem Cells In Mice with BCR-ABL Induced Myeloproliferative Disease (2010) (1)
- A JAK/STAT-MEDIATED INFLAMMATORY SIGNALING CASCADE DRIVES ONCOGENESIS IN AF10-REARRANGED AML. (2021) (1)
- hepatocellular carcinoma CDK 9-mediated transcription elongation is required for MYC addiction Material Supplemental (2014) (1)
- MLL-AF6 Mediated Transformation Is Dependent On the H3K79 Methyl-transferase Dot1l (2012) (1)
- Comparison of Human Genomics and Genetic Models of Cancer to Identify Novel Therapeutic Targets (2003) (1)
- Stem cells: Dual response to Ras mutation (2013) (1)
- MLL-AF9 and FLT3 Cooperation during Myeloid Leukemogenesis: Development of a Model for Rapid Testing of New Therapeutics. (2005) (1)
- Abstract 4958: VTP50469 is a novel, orally available menin-MLL1 inhibitor effective againstMLL-rearranged and NPM1-mutant leukemia (2018) (1)
- Pathprinting: An integrative approach to understand the functional basis of disease (2013) (1)
- Cell of Origin Influences Leukemia Stem Cell Phenotype. (2009) (1)
- Leukemia gene expression: MLL rearrangements in AML and ALL (2004) (1)
- Combined Targeting of the Menin-MLL1 Chromatin Complex and FLT3 As a Novel Therapeutic Concept Against NPM1 Mutant or MLL-Rearranged AML with Mutated FLT3 (2019) (1)
- The Menin Inhibitor Ziftomenib (KO-539) Synergizes with Agents Targeting Chromatin Regulation or Apoptosis and Sensitizes AML with MLL Rearrangement or NPM1 Mutation to Venetoclax (2022) (1)
- Loss of Lysine Histone Methyltransferase Setd2 Disrupts Normal Hematopoiesis, Lineage Commitment and Reveals a Novel Role for H3K36me3 in Immunoglobulin VDJ Recombination (2016) (1)
- The Interaction Between DOT1L and AF10 Is Required for H3K79 Dimethylation and MLL-AF9 Leukemia (2012) (0)
- Selective Expression of the Immunoregulatory Lectin, Galectin-1, in Precursor B Cell Acute Lymphoblastic Leukemias (ALLs) with MLL Rearrangements (2008) (0)
- Targeting BCL6-Mediated Drug-Resistance in High-Risk Childhood ALL (2012) (0)
- GSM679711: Bone marrow transduced with CALM-AF10, biological replicate-2 (2011) (0)
- Akt/foxo signaling pathway enforces the differentiation blockade in myeloid leukemias (2011) (0)
- Abstract 3457: Characterization of acquired resistance mutations to menin inhibitors (2023) (0)
- GSM679709: Bone marrow transduced with MIG, biological replicate-3 (2011) (0)
- acute lymphoblastic The JAK 2 V 617 F activating mutation occurs in chronic myelomonocytic (2005) (0)
- Hedgehog Signaling Is Dispensable for Adult Murine Hematopoiesis and Leukemogenesis. (2008) (0)
- lineage leukemia Recent progress toward epigenetic therapies: the example of mixed (2013) (0)
- Common Self-Renewal Pathways Contribute to the Induction of Acute Myeloid Leukemias Associated with Different Oncogenes (2008) (0)
- Context Dependent Role of Polycomb Repressive Complex 2 in Acute Leukemia (2014) (0)
- Inhibition Of Telomerase Is a Novel and Effective Therapy In MLL-Rearranged Acute Myeloid Leukemia (AML) (2013) (0)
- Comprehensive genomic profiling of hematologic malignancies by a clinical next generation sequencing-based assay (2013) (0)
- Genome-Wide RNAi Screen Identifies The Mechanistic Role For DOT1L In MLL-Rearranged Leukemia (2013) (0)
- Bmi-1 Is Dispensable for the Development of Acute Myeloid Leukemia Mediated by MLL-AF9 (2010) (0)
- Myeloid progenitor cluster formation drives regenerative and leukemic myelopoiesis (2016) (0)
- Acute Myeloid Leukemia Alters The Mesenchymal Stem Cell Potential Of The HSC Niche: Evidence For Modulation By β-Adrenergic Signals (2013) (0)
- MLL-AF9 Initiates Leukemia from a Single Committed Hematopoietic Progenitor. (2006) (0)
- Abstract SY35-03: Gene expression and epigenetic programs in leukemia stem cell development (2012) (0)
- Translocations de mll indiquant un profil d'expression genique distinct qui permet de distinguer une leucemie unique (2002) (0)
- UBR5 Is a Hect E3 Ubiquitin Ligase That Regulates Chromatin Bound Nuclear Hormone Receptor Stability (2022) (0)
- Pathway guided modules − Searching for causality in expression data in cancer cells (2010) (0)
- Leukemia Cell of Origin Influences p53 Activity and Therapeutic Sensitivity Via an Evi1-Dependent Mechanism (2019) (0)
- Table of Contents (1990) (0)
- Early Detection and Molecular Characterization of Therapy-Related Leukemia in Children Reveals Patterns of Disease Transformation and Guides Future Surveillance Protocols (2018) (0)
- Epitope Engineered Hematopoietic Stem and Progenitor Cells to Enable CAR-T Cell Immunotherapy for Acute Myeloid Leukemia (2022) (0)
- Development of the Stem Cell Discovery Engine (SCDE) (2010) (0)
- Abstract 883: NUP98-fusion proteins interact with the NSL/MLL1 complexes to drive leukemogenesis (2016) (0)
- Abstract 2694: Histone acetyltransferase activity of MOF is required for MLL-AF9 leukemogenesis (2016) (0)
- GSM679703: Bone marrow transduced with CALM-AF10 [delta]OM-LZ, biological replicate-3 (2011) (0)
- Abstract IA13: RNA regulators and the control of self-renewal (2017) (0)
- The Lysine Histone Methyltransferase SETD2 Is Required for Appropriate Immunoglobulin VDJ Recombination (2018) (0)
- Chasing leukemia stem cells (2014) (0)
- Peptidomimetic blockade of MYB in acute myeloid leukemia (2018) (0)
- MLL-Fusion Proteins Induce a Stem Cell Program in Committed Progenitors To Generate Leukemia Stem Cells. (2005) (0)
- Distinct Metabolic Dependency of Normal and Leukemic Cells in a Mouse Model (2011) (0)
- Utility of Combined DNA and RNA Next Generation Sequencing in Leukemias for Identification of Prognostic and Therapeutically Relevant Genomic Alterations in Clinical Practice (2014) (0)
- Meningeoma-1 Cooperates with MLL and DOT1L to Induce Leukemia (2015) (0)
- Mutant NPM1 Is Recruited to MLL Target Genes Via Its Acidic Stretch and Nuclear Export Factor CRM1 and Regulates Oncogenic Transcription in Acute Myeloid Leukemia (2022) (0)
- Targeting chromatin complexes in fusion protein-driven malignancies (2019) (0)
- Inhibition of MEK and DDR Pathways Induces Synergistic Killing of Novel Mll-Af4 B-ALL Model Harboring Activated Ras Mutations (2016) (0)
- leukemia rearranged infant acute lymphoblastic - Ara-C sensitivity in MLL gene metabolizing enzymes explains - Differential mRNA expression of Ara-C (2013) (0)
- An Epigenetic Regulator Screen Identifies Novel Targets That Sensitize MLL-Rearranged Leukemia to DOT1L Inhibition (2016) (0)
- IKZF2 Drives Self-Renewal and Blocks Myeloid Differentiation Programs in Myeloid Leukemic Stem Cells (2018) (0)
- lymphoblastic leukemia cells Genomewide identification of prednisolone-responsive genes in acute (2013) (0)
- Inherited Blood Cancer Predisposition through Altered Transcription Elongation (2021) (0)
- GSM679695: Bone marrow transduced with MIG, biological replicate-1 (2011) (0)
- GSM679704: Bone marrow transduced with CALM(400-648)+AF10 (677-758), biological replicate-1 (2011) (0)
- Aberrant Phosphorylation of MEF2C Is Dispensable for Hematopoiesis, and Induces Chemotherapy Resistance and Susceptibility to MARK Kinase Inhibition Therapy in Acute Myeloid Leukemia (2016) (0)
- Abstract IA22: Targeting histone modifying enzymes in leukemia (2014) (0)
- Abstract LB-23: In vivo exposure of infant leukemia to the BH3-mimetic ABT-263 selects for a cell death-resistant phenotype (2011) (0)
- Rationale for Targeting BCL6 in MLL-Rearranged B-ALL (2019) (0)
- Non-Catalytic Role of SETD1A Regulates DNA Repair in Leukemia (2016) (0)
- Comprehensive Genomic Profiling for Improved Diagnosis and Therapy of Pediatric Acute Leukemias (2016) (0)
- Suppression of HOX A cluster genes inhibits proliferation and induces cell death in human mixed-lineage leukemias (2007) (0)
- GSM679714: Bone marrow transduced with CALM-AF10 [delta]OM-LZ, biological replicate-2 (2011) (0)
- Editorial overview: Differentiation and disease. (2015) (0)
- Abstract 3841: Therapeutic targeting ofFLT3mutations in AML via menin-MLL1 and FLT3 inhibition (2019) (0)
- GSM679706: Bone marrow transduced with CALM(400-648)+AF10 (677-758), biological replicate-3 (2011) (0)
- Abstract 681: Targeted MLL-AF9 degradation is phenocopied by combined DOT1L and Menin inhibition (2022) (0)
- Author Correction: PGBD5 promotes site-specific oncogenic mutations in human tumors (2020) (0)
- leukemias -rearranged acute MLL HOXA9 is required for survival in human (2009) (0)
- 1 MEF 2 C phosphorylation is required for chemotherapy resistance in acute myeloid leukemia (2017) (0)
- MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer (2022) (0)
- Targeting Chromatin Complexes in MLL Rearranged Leukemia (2018) (0)
- Cell Stem Cell Genetic and Pharmacologic Targeting of CML LSCs of BCR-ABL ( by a retroviral fusion (2012) (0)
- AMLs rearranged MLL-AF 9 is critical for the pathogenesis of a subset of EVI 1 (2012) (0)
- Clinical Utility of Comprehensive Profiling of Genomic Alterations in Hematologic Malignancies (2014) (0)
- Oncogenic Feedback Activation Between BCL6 and MLL Promotes Malignant Transformation in MLL-RearrangedAcute Lymphoblastic Leukemia (2016) (0)
- B-Lymphoid Transcription Factors Restrict Glycolytic Energy Supply for Oncogenic Signaling (2015) (0)
- GSM679696: Bone marrow transduced with MIG, biological replicate-2 (2011) (0)
- Potent Ikaros Degradation By the Cereblon E3 Ligase Modulator CC-92480 Is Effective in Combination with Menin-MLL1 Inhibition in MLL1-Rearranged and NPM1-Mutant AML (2021) (0)
- GSM679705: Bone marrow transduced with CALM(400-648)+AF10 (677-758), biological replicate-2 (2011) (0)
- Aldehyde Dehydrogenase 3a2 (Aldh3a2) Represents a Distinct Metabolic Vulnerability in MLL-AF9 AML Leukemia Initiating Cells (2012) (0)
- Hoxa9+Meis1a Efficiently Transform Hematopoietic Stem Cells but Not Committed Progenitors. (2007) (0)
- Distinct and non-overlapping functions of Llgl1 and scribble in hematopoietic stem cells (2015) (0)
- Role of p21 in a Mouse Model of NUP98-HOXD13 Fusion Driven Myelodysplastic Syndromes (MDS) (2014) (0)
- leukemia or chronic lymphocytic leukemia leukemia and acute myeloid leukemia, but not in acute lymphoblastic The JAK2V617F activating mutation occurs in chronic myelomonocytic (2013) (0)
- Targeting Meningeoma-1 Driven AML through Epigenetic Modulation of the Cell of Origin (2014) (0)
- Abstract IA08: Targeting histone methylation in leukemia (2013) (0)
- Induction of Bim Facilitates Apoptosis in Leukemia Cells Treated with HDAC Inhibitors. (2006) (0)
- GSM679698: Bone marrow transduced with CALM-AF10, biological replicate-1 (2011) (0)
- 1 Targeting FLT 3 in primary MLL gene rearranged infant acute lymphoblastic leukemia (2005) (0)
- Genomic and Proteomic Analysis of Primary Chemoresistance and Induction Failure in Acute Myeloid Leukemia (2015) (0)
- LYMPHOID NEOPLASIA Integrated genomic DNA/RNA pro fi ling of hematologic malignancies in the clinical setting (2016) (0)
- Genetic or Pharmacological Inhibition of the Polycomb Group Protein BMI1 Impairs Leukemic Transformation Mediated By the CALM-AF10 Fusion Oncoprotein (2018) (0)
- RNA Binding Protein Syncrip Regulates the Leukemia Stem Cell Program (2016) (0)
- Epigenetic Resistance to Menin-MLL1 Inhibition Is Driven By Loss of the Non-Canonical Polycomb Repressive Complex 1.1 in NUP98-Rearranged AML (2022) (0)
- GSE27512: Identification of a Potently Oncogenic CALM-AF10 Minimal-Fusion Mutant (miRNA) (2011) (0)
- GSM679712: Bone marrow transduced with CALM-AF10, biological replicate-3 (2011) (0)
- Abstract IA020: Therapeutic targeting of MLL complexes in cancer (2022) (0)
- Regulation of HOX gene expression by AF10-mediated conversion of H3K79me1 to H3K79me2 (2014) (0)
- Tudor Domain-Focused CRISPR Dropout Screen Identifies SGF29 As a Novel Essential Gene in MLL-Rearranged Leukemias (2019) (0)
- Inactivation of the Cell Fate Determinate Llgl1 (Lethal Giant Larvae Homolog 1) Leads to Enhanced HSC Fitness and Predicts a Poor Prognosis in AML. (2012) (0)
- Forward genetic screen of human transposase genomic rearrangements (2016) (0)
- Structure-Guided Design of DOT1L Methyltransferase Inhibitors By a Novel, Label Free Assay Platform (2014) (0)
- BAP1 Loss Results in EZH2-Dependent Transformation in Myelodysplastic Syndromes (2015) (0)
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