Scott N. Keeney
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Computer Science
Scott N. Keeney's Degrees
- PhD Computer Science Stanford University
- Masters Computer Science University of California, Berkeley
- Bachelors Computer Science University of California, Berkeley
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Why Is Scott N. Keeney Influential?
(Suggest an Edit or Addition)According to Wikipedia, Scott Neal Keeney is an American molecular biologist. Early life and education Keeney was born on December 3, 1965, in Baltimore, Maryland. Growing up, he attended the Baltimore Polytechnic Institute and was allowed to use the laboratories at Johns Hopkins Bloomberg School of Public Health due to his mother's position as secretary in the Biochemistry Department. While attending Virginia Tech, Keeney came out as gay and enrolled at the University of California, Berkeley for his PhD. After receiving his PhD from UC Berkeley in 1993, Keeney decided to switch fields and change his focus from mammalian cells to yeast. While attending a presentation on a paper written by Nancy Kleckner, he was inspired to apply for a post-doctoral position in her laboratory.
Scott N. Keeney's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Meiosis-Specific DNA Double-Strand Breaks Are Catalyzed by Spo11, a Member of a Widely Conserved Protein Family (1997) (1689)
- Recombinational DNA double-strand breaks in mice precede synapsis (2001) (856)
- Chromosome synapsis defects and sexually dimorphic meiotic progression in mice lacking Spo11. (2000) (655)
- Mechanism and control of meiotic recombination initiation. (2001) (655)
- Endonucleolytic processing of covalent protein-linked DNA double-strand breaks (2005) (566)
- A Hierarchical Combination of Factors Shapes the Genome-wide Topography of Yeast Meiotic Recombination Initiation (2011) (482)
- Clarifying the mechanics of DNA strand exchange in meiotic recombination (2006) (394)
- Mouse HORMAD1 and HORMAD2, Two Conserved Meiotic Chromosomal Proteins, Are Depleted from Synapsed Chromosome Axes with the Help of TRIP13 AAA-ATPase (2009) (345)
- Where the crossovers are: recombination distributions in mammals (2004) (338)
- Mechanism and regulation of meiotic recombination initiation. (2014) (337)
- Crossover Homeostasis in Yeast Meiosis (2006) (330)
- Spo11 and the Formation of DNA Double-Strand Breaks in Meiosis. (2008) (290)
- Initiation of meiotic recombination by formation of DNA double-strand breaks: mechanism and regulation. (2006) (229)
- ATM controls meiotic double-strand break formation (2011) (227)
- Progression of meiotic DNA replication is modulated by interchromosomal interaction proteins, negatively by Spo11p and positively by Rec8p. (2000) (226)
- Distinct DNA-damage-dependent and -independent responses drive the loss of oocytes in recombination-defective mouse mutants. (2005) (218)
- Characterization of a human DNA damage binding protein implicated in xeroderma pigmentosum E. (1993) (217)
- Homeostatic control of recombination is implemented progressively in mouse meiosis (2012) (217)
- Covalent protein-DNA complexes at the 5' strand termini of meiosis-specific double-strand breaks in yeast. (1995) (216)
- Distinct Properties of the XY Pseudoautosomal Region Crucial for Male Meiosis (2011) (211)
- Comparative analysis of binding of human damaged DNA-binding protein (XPE) and Escherichia coli damage recognition protein (UvrA) to the major ultraviolet photoproducts: T[c,s]T, T[t,s]T, T[6-4]T, and T[Dewar]T. (1993) (205)
- Self-organization of meiotic recombination initiation: general principles and molecular pathways. (2014) (202)
- Meiotic homologue alignment and its quality surveillance are controlled by mouse HORMAD1 (2011) (199)
- Surveillance of Different Recombination Defects in Mouse Spermatocytes Yields Distinct Responses despite Elimination at an Identical Developmental Stage (2005) (198)
- Genome destabilization by homologous recombination in the germ line (2010) (198)
- The Landscape of Mouse Meiotic Double-Strand Break Formation, Processing, and Repair (2016) (195)
- Computed structures of core eukaryotic protein complexes (2021) (176)
- Homologue engagement controls meiotic DNA break number and distribution (2014) (172)
- Mouse TRIP13/PCH2 Is Required for Recombination and Normal Higher-Order Chromosome Structure during Meiosis (2010) (169)
- Chromosomal localization and cDNA cloning of the genes (DDB1 and DDB2) for the p127 and p48 subunits of a human damage-specific DNA binding protein. (1995) (167)
- Antiviral protein Ski8 is a direct partner of Spo11 in meiotic DNA break formation, independent of its cytoplasmic role in RNA metabolism. (2004) (158)
- Tying synaptonemal complex initiation to the formation and programmed repair of DNA double-strand breaks. (2004) (154)
- Numerical constraints and feedback control of double-strand breaks in mouse meiosis. (2013) (152)
- Cyclin-Dependent Kinase Directly Regulates Initiation of Meiotic Recombination (2006) (148)
- Correction of the DNA repair defect in xeroderma pigmentosum group E by injection of a DNA damage-binding protein. (1994) (123)
- A global view of meiotic double-strand break end resection (2016) (116)
- Interactions between Mei4, Rec114, and other proteins required for meiotic DNA double-strand break formation in Saccharomyces cerevisiae (2007) (116)
- ketu mutant mice uncover an essential meiotic function for the ancient RNA helicase YTHDC2 (2017) (112)
- Meiotic DNA break formation requires the unsynapsed chromosome axis-binding protein IHO1 (CCDC36) in mice (2016) (112)
- A mouse homolog of the Saccharomyces cerevisiae meiotic recombination DNA transesterase Spo11p. (1999) (110)
- Temporospatial Coordination of Meiotic DNA Replication and Recombination via DDK Recruitment to Replisomes (2014) (103)
- ATM Promotes the Obligate XY Crossover and both Crossover Control and Chromosome Axis Integrity on Autosomes (2008) (102)
- Identification of Residues in Yeast Spo11p Critical for Meiotic DNA Double-Strand Break Formation (2002) (101)
- Mouse tetrad analysis provides insights into recombination mechanisms and hotspot evolutionary dynamics (2014) (100)
- Comprehensive, fine-scale dissection of homologous recombination outcomes at a hot spot in mouse meiosis. (2010) (94)
- The kinetochore prevents centromere-proximal crossover recombination during meiosis (2015) (94)
- Evolutionary conservation of meiotic DSB proteins: more than just Spo11. (2010) (93)
- Nonparadoxical evolutionary stability of the recombination initiation landscape in yeast (2015) (91)
- Evolutionarily diverse determinants of meiotic DNA break and recombination landscapes across the genome (2014) (87)
- Spatial organization and dynamics of the association of Rec102 and Rec104 with meiotic chromosomes (2004) (81)
- The ATM Signaling Cascade Promotes Recombination-Dependent Pachytene Arrest in Mouse Spermatocytes (2015) (77)
- The E3 ubiquitin ligase Cullin 4A regulates meiotic progression in mouse spermatogenesis. (2011) (76)
- Functional interactions between SPO11 and REC102 during initiation of meiotic recombination in Saccharomyces cerevisiae. (2002) (70)
- Biochemical heterogeneity in xeroderma pigmentosum complementation group E. (1992) (70)
- Regulating the formation of DNA double-strand breaks in meiosis. (2008) (70)
- Synaptonemal complex formation: where does it start? (2005) (68)
- Communication between homologous chromosomes: genetic alterations at a nuclease‐hypersensitive site can alter mitotic chromatin structure at that site both in cis and in trans (1996) (68)
- H2B (Ser10) Phosphorylation is Induced during Apoptosis and Meiosis in S. cerevisiae (2005) (64)
- REC114 partner ANKRD31 controls number, timing and location of meiotic DNA breaks (2018) (62)
- The tricky path to recombining X and Y chromosomes in meiosis (2012) (58)
- Ensuring meiotic DNA break formation in the mouse pseudoautosomal region (2019) (57)
- DNA polymerase β is critical for mouse meiotic synapsis (2010) (53)
- Genomic and chromatin features shaping meiotic double-strand break formation and repair in mice (2017) (49)
- Numerical and spatial patterning of yeast meiotic DNA breaks by Tel1 (2016) (49)
- The Rad50 hook domain regulates DNA damage signaling and tumorigenesis (2014) (46)
- Gel electrophoresis assays for analyzing DNA double-strand breaks in Saccharomyces cerevisiae at various spatial resolutions. (2009) (45)
- Exploiting Spore-Autonomous Fluorescent Protein Expression to Quantify Meiotic Chromosome Behaviors in Saccharomyces cerevisiae (2011) (44)
- High-Resolution Global Analysis of the Influences of Bas1 and Ino4 Transcription Factors on Meiotic DNA Break Distributions in Saccharomyces cerevisiae (2015) (43)
- The Configuration of RPA, RAD51, and DMC1 Binding in Meiosis Reveals the Nature of Critical Recombination Intermediates (2020) (43)
- rahu is a mutant allele of Dnmt3c, encoding a DNA methyltransferase homolog required for meiosis and transposon repression in the mouse male germline (2017) (43)
- ATR is a multifunctional regulator of male mouse meiosis (2017) (42)
- Mechanisms of germ line genome instability. (2016) (40)
- DNA-driven condensation assembles the meiotic DNA break machinery (2021) (40)
- ATR is required to complete meiotic recombination in mice (2017) (39)
- A critical review of permeabilized cell systems for studying mammalian DNA repair. (1990) (39)
- Local and sex-specific biases in crossover vs. noncrossover outcomes at meiotic recombination hot spots in mice (2015) (39)
- p53 and TAp63 participate in the recombination-dependent pachytene arrest in mouse spermatocytes (2017) (38)
- Preaching about the converted: how meiotic gene conversion influences genomic diversity (2012) (38)
- Persistent DNA-break potential near telomeres increases initiation of meiotic recombination on short chromosomes (2018) (38)
- Cyclin B3 promotes anaphase I onset in oocyte meiosis (2019) (37)
- Multilayered mechanisms ensure that short chromosomes recombine in meiosis (2018) (37)
- Molecular basis for enhancement of the meiotic DMC1 recombinase by RAD51 associated protein 1 (RAD51AP1) (2011) (36)
- Mouse BAZ1A (ACF1) Is Dispensable for Double-Strand Break Repair but Is Essential for Averting Improper Gene Expression during Spermatogenesis (2013) (34)
- Shu complex SWS1-SWSAP1 promotes early steps in mouse meiotic recombination (2018) (34)
- Molecular structures and mechanisms of DNA break processing in mouse meiosis (2019) (33)
- Scale matters (2012) (33)
- Distinct DNA-binding surfaces in the ATPase and linker domains of MutLγ determine its substrate specificities and exert separable functions in meiotic recombination and mismatch repair (2017) (32)
- Expression of Arf Tumor Suppressor in Spermatogonia Facilitates Meiotic Progression in Male Germ Cells (2011) (32)
- A role for histone H2B during repair of UV-induced DNA damage in Saccharomyces cerevisiae. (2002) (31)
- End-labeling and analysis of Spo11-oligonucleotide complexes in Saccharomyces cerevisiae. (2009) (31)
- Meiotic recombination: Making and breaking go hand in hand (2001) (29)
- Meiotic Recombination Initiation in and around Retrotransposable Elements in Saccharomyces cerevisiae (2013) (28)
- Dynamics of DOT1L localization and H3K79 methylation during meiotic prophase I in mouse spermatocytes (2014) (26)
- Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages. (2006) (25)
- Histone methylation sets the stage for meiotic DNA breaks (2009) (25)
- Histone H3 Threonine 11 Phosphorylation Is Catalyzed Directly by the Meiosis-Specific Kinase Mek1 and Provides a Molecular Readout of Mek1 Activity in Vivo (2017) (23)
- Control of meiotic double-strand-break formation by ATM: local and global views (2017) (23)
- Structural and functional characterization of the Spo11 core complex (2020) (22)
- Meiotic crossover hotspots contained in haplotype block boundaries of the mouse genome (2007) (22)
- Chromosome-autonomous feedback down-regulates meiotic DNA break competence upon synaptonemal complex formation (2020) (21)
- Mechanistic insight into crossing over during mouse meiosis (2019) (20)
- Molecular Cartography: Mapping the Landscape of Meiotic Recombination (2007) (18)
- YTHDC2 is essential for pachytene progression and prevents aberrant microtubule-driven telomere clustering in male meiosis (2021) (17)
- Mice deficient for the type II topoisomerase‐like DNA transesterase Spo11 show normal immunoglobulin somatic hypermutation and class switching (2002) (17)
- Exo1 recruits Cdc5 polo kinase to MutLγ to ensure efficient meiotic crossover formation (2020) (16)
- Structures of core eukaryotic protein complexes (2021) (15)
- Modifying Histones and Initiating Meiotic Recombination New Answers to an Old Question (2004) (15)
- Concerted cutting by Spo11 illuminates meiotic DNA break mechanics (2021) (14)
- Sex and the single (double-strand) break. (2002) (14)
- How much is enough? Control of DNA double-strand break numbers in mouse meiosis (2013) (14)
- Probing meiotic recombination decisions. (2008) (13)
- YTHDC2 control of gametogenesis requires helicase activity but not m6A binding (2022) (12)
- Sequencing Spo11 Oligonucleotides for Mapping Meiotic DNA Double-Strand Breaks in Yeast. (2017) (12)
- S1-seq Assay for Mapping Processed DNA Ends. (2018) (10)
- Homologous Recombination: Needing to Have My Say (2005) (9)
- The Joy of Six: How to Control Your Crossovers (2012) (8)
- Cyclin B3 is dispensable for mouse spermatogenesis (2019) (8)
- DDK links replication and recombination in meiosis (2014) (8)
- DNA-dependent macromolecular condensation drives self-assembly of the meiotic DNA break machinery (2020) (8)
- De novo deletions and duplications at recombination hotspots in mouse germlines (2021) (8)
- Detection of SPO11-oligonucleotide complexes from mouse testes. (2009) (7)
- Meiosis. Volume 2, cytological methods. Preface. (2009) (7)
- Breaking DNA (2016) (6)
- Meiosis : Volume 1, Molecular and Genetic Methods (2009) (5)
- shani mutation in mouse affects splicing of Spata22 and leads to impaired meiotic recombination (2020) (5)
- Mechanism of in vivo activation of the MutLγ-Exo1 complex for meiotic crossover formation (2019) (5)
- Cisplatin-induced alterations in the expression of the mRNAs for UV-damage recognition protein. (1996) (5)
- Homologous Recombination During Meiosis (2016) (5)
- Dynamics of DOT1L localization and H3K79 methylation during meiotic prophase I in mouse spermatocytes (2013) (5)
- MEIOB and SPATA22 resemble RPA subunits and interact with the RPA complex to promote meiotic recombination (2018) (5)
- Concerted cutting by Spo11 illuminates DNA break mechanisms and initiates gap repair during meiosis (2019) (5)
- Triple-helix potential of the mouse genome (2022) (5)
- Zip it up to shut it down (2014) (4)
- yama, a mutant allele of Mov10l1, disrupts retrotransposon silencing and piRNA biogenesis (2020) (4)
- Special issue on “recent advances in meiotic chromosome structure, recombination and segregation” (2016) (4)
- How do small chromosomes know they are small? Maximizing meiotic break formation on the shortest yeast chromosomes (2021) (4)
- Meiosis. Volume 1, molecular and genetic methods. Preface. (2009) (4)
- Analysis of recombinants in female mouse meiosis. (2013) (4)
- PCH'ing Together an Understanding of Crossover Control (2009) (3)
- De novo deletions and duplications at recombination hotspots in mouse germlines (2020) (2)
- Structural and functional characterization of the Spo11 core complex (2021) (2)
- Shu complex SWS1-SWSAP1 promotes early steps in mouse meiotic recombination (2018) (1)
- Non-paradoxical evolutionary stability of the recombination initiation landscape in Saccharomycetes (2015) (1)
- UvA-DARE ( Digital Academic Repository ) Mouse TRIP 13 / PCH 2 Is Required for Recombination and Normal Higher-Order Chromosome Structure during (2010) (1)
- Chromosome-autonomous feedback downregulates meiotic DSB competence upon synaptonemal complex formation (2020) (1)
- Structure and DNA bridging activity of the essential Rec114–Mei4 trimer interface (2023) (1)
- ATM suppresses c-Myc overexpression in the mammary epithelium in response to estrogen (2022) (0)
- Persistent DNA-break potential near telomeres increases initiation of meiotic recombination on short chromosomes (2019) (0)
- Molecular Basis for Enhancement of the Meiotic DMCI Recombinase by RAD51AP1 (2011) (0)
- Special issue on “recent advances in meiotic chromosome structure, recombination and segregation” (2016) (0)
- Cyclin B3 promotes APC/C activation and anaphase I onset in oocyte meiosis (2018) (0)
- Molecular and genetic methods (2009) (0)
- S1-seq assay for mapping processed DNA ends (2017) (0)
- A long-sou g ht prot e in tha t help s t o bre ak DN A is fi nal l y disc o v ere d (2016) (0)
- The tricky path to recombining sex chromosomes in meiosis (2012) (0)
- Editorial: Meiosis: From Molecular Basis to Medicine (2021) (0)
- Abstract A07: The RAD51 paralog complex SWS1-SWSAP1 is critical for homologous recombination in the mouse (2017) (0)
- Ensuring meiotic DNA break formation in the mouse pseudoautosomal region (2020) (0)
- shani mutation in mouse affects splicing of Spata22 and leads to impaired meiotic recombination (2020) (0)
- ATR is a multifunctional regulator of male mouse meiosis (2018) (0)
- Meiosis: Disentangling polyploid chromosomes with supercharged crossover interference (2021) (0)
- Shu complex SWS1-SWSAP1 is required for mouse meiotic recombination in concert with the BRCA2 C terminus (2017) (0)
- Meiotic machinations (2000) (0)
- ATR is required to complete meiotic recombination in mice (2018) (0)
- Essential roles of the ANKRD31-REC114 interaction in meiotic recombination and mouse spermatogenesis (2023) (0)
- Multilayered mechanisms ensure that short chromosomes recombine in meiosis (2020) (0)
- Meiotic crossover control - from DNA breakage to DNA repair (2013) (0)
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