Scott L. Friedman
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American physician
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Why Is Scott L. Friedman Influential?
(Suggest an Edit or Addition)According to Wikipedia, Scott L. Friedman is an American scientist, professor and physician who works in the field of hepatology. Friedman has conducted pioneering research into the underlying causes of scarring, or fibrosis, associated with chronic liver disease, by characterizing the key fibrogenic cell type, the hepatic stellate cell His laboratory has also discovered a novel tumor suppressor gene, KLF6 that is inactivated in a number of human cancers including primary liver cancer. Friedman is the Fishberg Professor of Medicine, and Chief of the Division of Liver Diseases, Mount Sinai School of Medicine in New York. Friedman has two children, a son, Leor Friedman, and a daughter, Yael Friedman.
Scott L. Friedman's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012) (2913)
- Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. (2008) (2382)
- Molecular Regulation of Hepatic Fibrosis, an Integrated Cellular Response to Tissue Injury* (2000) (2083)
- Mechanisms of NAFLD development and therapeutic strategies (2018) (1733)
- Liver fibrosis -- from bench to bedside. (2003) (1656)
- Mechanisms of hepatic fibrogenesis. (2008) (1546)
- The Cellular Basis of Hepatic Fibrosis -- Mechanisms and Treatment Strategies (1993) (1483)
- Mechanisms of hepatic stellate cell activation (2017) (1458)
- Weight Loss Through Lifestyle Modification Significantly Reduces Features of Nonalcoholic Steatohepatitis. (2015) (1386)
- Gene expression in fixed tissues and outcome in hepatocellular carcinoma. (2008) (1158)
- Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma. (2009) (900)
- p53 Activates the CD95 (APO-1/Fas) Gene in Response to DNA Damage by Anticancer Drugs (1998) (898)
- Pathogenesis of liver fibrosis. (2011) (855)
- Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis (2004) (836)
- Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 (2021) (811)
- Hepatic lipocytes: the principal collagen-producing cells of normal rat liver. (1985) (810)
- Liver Cancer Cell of Origin, Molecular Class, and Effects on Patient Prognosis. (2017) (718)
- Pathobiology of liver fibrosis: a translational success story (2015) (703)
- Hepatic stellate cells and liver fibrosis. (2013) (688)
- Hepatic stellate cells as key target in liver fibrosis. (2017) (676)
- Pivotal role of mTOR signaling in hepatocellular carcinoma. (2008) (675)
- Genome‐wide molecular profiles of HCV‐induced dysplasia and hepatocellular carcinoma (2007) (645)
- Role of the microenvironment in the pathogenesis and treatment of hepatocellular carcinoma. (2013) (595)
- Therapy for Fibrotic Diseases: Nearing the Starting Line (2013) (586)
- Focal gains of VEGFA and molecular classification of hepatocellular carcinoma. (2008) (566)
- Genomics and signaling pathways in hepatocellular carcinoma. (2007) (553)
- Identification of an Immune-specific Class of Hepatocellular Carcinoma, Based on Molecular Features. (2017) (545)
- Evolving challenges in hepatic fibrosis (2010) (540)
- Apoptosis: The nexus of liver injury and fibrosis (2004) (514)
- Hepatic fibrosis: Concept to treatment. (2015) (505)
- Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues. (2012) (502)
- A randomized, placebo‐controlled trial of cenicriviroc for treatment of nonalcoholic steatohepatitis with fibrosis (2018) (481)
- Now there are many (stages) where before there was one: In search of a pathophysiological classification of cirrhosis (2010) (473)
- Mechanisms of Disease: mechanisms of hepatic fibrosis and therapeutic implications (2004) (466)
- KLF6, a Candidate Tumor Suppressor Gene Mutated in Prostate Cancer (2001) (460)
- Activation of hepatic stellate cells--a key issue in liver fibrosis. (2002) (445)
- Risk factors and prevention of hepatocellular carcinoma in the era of precision medicine. (2017) (422)
- The Movement of Aquatic Mercury Through Terrestrial Food Webs (2008) (404)
- Mechanisms of hepatic fibrogenesis. (2011) (388)
- Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium. Direct enhancement of matrix synthesis and stimulation of cell proliferation via induction of platelet-derived growth factor receptors. (1989) (386)
- Mechanisms and disease consequences of nonalcoholic fatty liver disease (2021) (385)
- Leptin in hepatic fibrosis: Evidence for increased collagen production in stellate cells and lean littermates of ob/ob mice (2002) (381)
- A molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosis. (2006) (381)
- Apoptotic Body Engulfment by a Human Stellate Cell Line Is Profibrogenic (2003) (378)
- Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. (1993) (376)
- Reversal of hepatic fibrosis — Fact or fantasy? (2006) (375)
- Functions of autophagy in normal and diseased liver (2013) (372)
- Cytokines and fibrogenesis. (1999) (359)
- Rat hepatic lipocytes express smooth muscle actin upon activation in vivo and in culture. (1992) (347)
- Fibrosis‐dependent mechanisms of hepatocarcinogenesis (2012) (341)
- Maintenance of differentiated phenotype of cultured rat hepatic lipocytes by basement membrane matrix. (1989) (337)
- Isolation and culture of hepatic lipocytes, Kupffer cells, and sinusoidal endothelial cells by density gradient centrifugation with Stractan. (1987) (334)
- Senolytic CAR T cells reverse senescence-associated pathologies (2020) (333)
- Hepatic fibrosis -- overview. (2008) (325)
- Hepatic stellate cells. (1996) (325)
- Liver fibrogenesis and the role of hepatic stellate cells: New insights and prospects for therapy (1999) (321)
- A 7 gene signature identifies the risk of developing cirrhosis in patients with chronic hepatitis C (2007) (307)
- Induction of beta-platelet-derived growth factor receptor in rat hepatic lipocytes during cellular activation in vivo and in culture. (1994) (293)
- Isolated hepatic lipocytes and kupffer cells from normal human liver: Morphological and functional characteristics in primary culture (1992) (289)
- Challenges and opportunities in drug and biomarker development for nonalcoholic steatohepatitis: Findings and recommendations from an American Association for the Study of Liver Diseases–U.S. Food and Drug Administration Joint Workshop (2015) (284)
- An immortalized rat liver stellate cell line (HSC-T6): a new cell model for the study of retinoid metabolism in vitro. (2000) (268)
- Anti-fibrotic activity of NK cells in experimental liver injury through killing of activated HSC. (2006) (263)
- A simple diet- and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer. (2018) (262)
- Antiangiogenic treatment with Sunitinib ameliorates inflammatory infiltrate, fibrosis, and portal pressure in cirrhotic rats (2007) (261)
- Stimulation and proliferation of primary rat hepatic stellate cells by cytochrome P450 2E1–derived reactive oxygen species (2002) (259)
- Current and future therapeutic regimens for nonalcoholic fatty liver disease and nonalcoholic steatohepatitis (2018) (254)
- Activation-dependent contractility of rat hepatic lipocytes in culture and in vivo. (1993) (253)
- Phagocytosis of apoptotic bodies by hepatic stellate cells induces NADPH oxidase and is associated with liver fibrosis in vivo (2006) (253)
- Zf9, a Kruppel-like transcription factor up-regulated in vivo during early hepatic fibrosis. (1998) (250)
- DDR2 receptor promotes MMP-2-mediated proliferation and invasion by hepatic stellate cells. (2001) (249)
- Transcriptional activation of transforming growth factor beta1 and its receptors by the Kruppel-like factor Zf9/core promoter-binding protein and Sp1. Potential mechanisms for autocrine fibrogenesis in response to injury. (1998) (249)
- Diagnostic modalities for nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, and associated fibrosis (2017) (248)
- Molecular regulation of hepatic fibrogenesis. (1998) (248)
- Toll-like receptor 4 signaling in liver injury and hepatic fibrogenesis (2010) (246)
- Expression and role of Bcl‐xL in human hepatocellular carcinomas (2001) (245)
- Antifibrotic Effects of the Dual CCR2/CCR5 Antagonist Cenicriviroc in Animal Models of Liver and Kidney Fibrosis (2016) (232)
- Ras pathway activation in hepatocellular carcinoma and anti-tumoral effect of combined sorafenib and rapamycin in vivo. (2009) (227)
- Immune stimulation of hepatic fibrogenesis by CD8 cells and attenuation by transgenic interleukin-10 from hepatocytes. (2004) (227)
- Activated stellate cells express the TRAIL receptor‐2/death receptor‐5 and undergo TRAIL‐mediated apoptosis (2003) (226)
- MicroRNA-based classification of hepatocellular carcinoma and oncogenic role of miR-517a. (2011) (223)
- Discoidin Domain Receptor 2 Regulates Fibroblast Proliferation and Migration through the Extracellular Matrix in Association with Transcriptional Activation of Matrix Metalloproteinase-2* (2002) (222)
- A germline DNA polymorphism enhances alternative splicing of the KLF6 tumor suppressor gene and is associated with increased prostate cancer risk. (2005) (220)
- Fibrogenesis I. New insights into hepatic stellate cell activation: the simple becomes complex. (2000) (220)
- Adenosine A2A receptors play a role in the pathogenesis of hepatic cirrhosis (2006) (216)
- Human hepatic lipocytes synthesize tissue inhibitor of metalloproteinases-1. Implications for regulation of matrix degradation in liver. (1992) (214)
- Functional linkage of cirrhosis‐predictive single nucleotide polymorphisms of toll‐like receptor 4 to hepatic stellate cell responses (2009) (212)
- Experimental models of hepatocellular carcinoma. (2008) (210)
- Hepatic fibrosis--role of hepatic stellate cell activation. (2002) (195)
- Cellular sources of collagen and regulation of collagen production in liver. (1990) (194)
- Innate immunity in alcoholic liver disease. (2011) (193)
- Hepatic fibrosis. Pathogenesis and principles of therapy. (2001) (193)
- Proangiogenic role of tumor‐activated hepatic stellate cells in experimental melanoma metastasis (2003) (192)
- Is liver fibrosis reversible? (2001) (191)
- The Kruppel-like factor 6 genotype is associated with fibrosis in nonalcoholic fatty liver disease. (2008) (185)
- Prognostic gene expression signature for patients with hepatitis C-related early-stage cirrhosis. (2013) (185)
- Cytochrome P450 2E1-derived Reactive Oxygen Species Mediate Paracrine Stimulation of Collagen I Protein Synthesis by Hepatic Stellate Cells* (2002) (185)
- Current status of novel antifibrotic therapies in patients with chronic liver disease (2011) (185)
- Transcriptional activation of endoglin and transforming growth factor-beta signaling components by cooperative interaction between Sp1 and KLF6: their potential role in the response to vascular injury. (2002) (184)
- Early Liver Transplantation for Severe Alcoholic Hepatitis in the United States—A Single‐Center Experience (2016) (183)
- Endoplasmic reticulum stress induces fibrogenic activity in hepatic stellate cells through autophagy. (2013) (183)
- Regression of Fibrosis and Reversal of Cirrhosis in Rats by Galectin Inhibitors in Thioacetamide-Induced Liver Disease (2013) (183)
- Combination therapy for hepatocellular carcinoma: additive preclinical efficacy of the HDAC inhibitor panobinostat with sorafenib. (2012) (182)
- Scraping fibrosis: Expressway to the core of fibrosis (2011) (182)
- Inhibition of rat hepatic lipocyte activation in culture by interferon‐γ (1992) (182)
- Future research directions in idiopathic pulmonary fibrosis: summary of a National Heart, Lung, and Blood Institute working group. (2002) (181)
- Free fatty acids repress small heterodimer partner (SHP) activation and adiponectin counteracts bile acid‐induced liver injury in superobese patients with nonalcoholic steatohepatitis (2013) (179)
- Kruppel-like factor 6 (KLF6) is a tumor-suppressor gene frequently inactivated in colorectal cancer. (2004) (177)
- CYP2E1‐mediated oxidative stress induces collagen type I expression in rat hepatic stellate cells (1999) (175)
- Lipocytes from normal rat liver release a neutral metalloproteinase that degrades basement membrane (type IV) collagen. (1989) (171)
- Targeted inhibition of the KLF6 splice variant, KLF6 SV1, suppresses prostate cancer cell growth and spread. (2005) (170)
- Efficacy and safety study of cenicriviroc for the treatment of non-alcoholic steatohepatitis in adult subjects with liver fibrosis: CENTAUR Phase 2b study design. (2016) (167)
- Regression of Fibrosis after Chronic Stimulation of Cannabinoid CB2 Receptor in Cirrhotic Rats (2008) (167)
- Krüppel-like Factor-6 Promotes Preadipocyte Differentiation through Histone Deacetylase 3-dependent Repression of DLK1* (2005) (164)
- Cyclin-Dependent Kinase Inhibition by the KLF6 Tumor Suppressor Protein through Interaction with Cyclin D1 (2004) (157)
- Frequent inactivation of the tumor suppressor Kruppel‐like factor 6 (KLF6) in hepatocellular carcinoma (2004) (152)
- Molecular Liver Cancer Prevention in Cirrhosis by Organ Transcriptome Analysis and Lysophosphatidic Acid Pathway Inhibition. (2016) (150)
- Collagen measured in primary cultures of normal rat hepatocytes derives from lipocytes within the monolayer. (1988) (150)
- Detection of novel biomarkers of liver cirrhosis by proteomic analysis (2009) (148)
- Antifibrotic effects of CXCL9 and its receptor CXCR3 in livers of mice and humans. (2009) (147)
- Wnt-Pathway Activation in Two Molecular Classes of Hepatocellular Carcinoma and Experimental Modulation by Sorafenib (2012) (143)
- Acute liver failure is associated with elevated liver stiffness and hepatic stellate cell activation (2010) (142)
- Inhibition of PDGF, TGF-β, and Abl signaling and reduction of liver fibrosis by the small molecule Bcr-Abl tyrosine kinase antagonist Nilotinib. (2011) (141)
- Mechanisms and therapy of hepatic fibrosis: Report of the AASLD single topic basic research conference (2000) (140)
- Modulation of transforming growth factor beta receptors of rat lipocytes during the hepatic wound healing response. Enhanced binding and reduced gene expression accompany cellular activation in culture and in vivo. (1994) (140)
- The Role of Chemokines in Acute Liver Injury (2012) (139)
- Immunolocalization of laminin in normal rat liver and biosynthesis of laminin by hepatic lipocytes in primary culture. (1988) (137)
- Secretion of 72 kDa type IV collagenase/gelatinase by cultured human lipocytes. Analysis of gene expression, protein synthesis and proteinase activity. (1992) (137)
- Developmental regulation of yolk sac hematopoiesis by Kruppel-like factor 6. (2006) (136)
- Adenovirus-mediated expression of BMP-7 suppresses the development of liver fibrosis in rats (2006) (136)
- Transcriptional activation of urokinase by the Krüppel-like factor Zf9/COPEB activates latent TGF-beta1 in vascular endothelial cells. (2000) (134)
- Transplantation trends in primary biliary cirrhosis. (2007) (133)
- Activation of hepatic stellate cells after phagocytosis of lymphocytes: A novel pathway of fibrogenesis (2008) (133)
- PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis (2016) (132)
- Coordinated induction of VEGF receptors in mesenchymal cell types during rat hepatic wound healing (1998) (131)
- Discoidin Domain Receptor 2 Interacts with Src and Shc following Its Activation by Type I Collagen* (2002) (131)
- β-PDGF Receptor Expressed by Hepatic Stellate Cells Regulates Fibrosis in Murine Liver Injury, but Not Carcinogenesis (2015) (129)
- Phosphorylation of retinoid X receptor alpha at serine 260 impairs its metabolism and function in human hepatocellular carcinoma. (2001) (129)
- Connective tissue biology and hepatic fibrosis: Report of a conference (1990) (125)
- Impaired endothelial autophagy promotes liver fibrosis by aggravating the oxidative stress response during acute liver injury. (2019) (125)
- Dendritic cell regulation of carbon tetrachloride–induced murine liver fibrosis regression (2012) (124)
- Reversal, maintenance or progression: what happens to the liver after a virologic cure of hepatitis C? (2014) (124)
- Elevated AGE-Modified ApoB in Sera of Euglycemic, Normolipidemic Patients with Atherosclerosis: Relationship to Tissue AGEs (1997) (124)
- Ethanol and Arachidonic Acid Increase α2(I) Collagen Expression in Rat Hepatic Stellate Cells Overexpressing Cytochrome P450 2E1 (2000) (124)
- Identification of two gene variants associated with risk of advanced fibrosis in patients with chronic hepatitis C. (2006) (123)
- Evaluation of a new rapid quantitative immunoassay for serum myoglobin versus CK-MB for ruling out acute myocardial infarction in the emergency department. (1994) (120)
- Molecular basis of hepatic fibrosis (2003) (120)
- A novel murine model to deplete hepatic stellate cells uncovers their role in amplifying liver damage in mice (2013) (120)
- Stellate cells: A moving target in hepatic fibrogenesis (2004) (119)
- Gene-expression signature of vascular invasion in hepatocellular carcinoma. (2011) (115)
- Wnt-pathway activation in two molecular classes of hepatocellular carcinoma and experimental modulation by sorafenib. (2012) (115)
- Formation of extracellular matrix in normal rat liver: lipocytes as a major source of proteoglycan. (1988) (114)
- Mechanism of retarded liver regeneration in plasminogen activator‐deficient mice: Impaired activation of hepatocyte growth factor after Fas‐mediated massive hepatic apoptosis (2001) (114)
- Amelioration of hepatic fibrosis by NK cell activation (2010) (113)
- KLF6-SV1 overexpression accelerates human and mouse prostate cancer progression and metastasis. (2008) (111)
- Roles of KLF6 and KLF6-SV1 in Ovarian Cancer Progression and Intraperitoneal Dissemination (2006) (110)
- Stellate cell activation in alcoholic fibrosis--an overview. (1999) (109)
- Hepatic fibrosis 2006: Report of the third AASLD Single Topic Conference (2007) (108)
- Kupffer cell activation by ambient air particulate matter exposure may exacerbate non-alcoholic fatty liver disease (2009) (107)
- Reduced nicotinamide adenine dinucleotide phosphate oxidase 2 plays a key role in stellate cell activation and liver fibrogenesis in vivo. (2010) (107)
- Retinol release by activated rat hepatic lipocytes: regulation by Kupffer cell-conditioned medium and PDGF. (1993) (105)
- BMP-7 opposes TGF-beta1-mediated collagen induction in mouse pulmonary myofibroblasts through Id2. (2006) (105)
- Ras promotes growth by alternative splicing-mediated inactivation of the KLF6 tumor suppressor in hepatocellular carcinoma. (2008) (103)
- NRBF2 Regulates Autophagy and Prevents Liver Injury by Modulating Atg14L-Linked Phosphatidylinositol-3 Kinase III Activity (2014) (103)
- A hepatic stellate cell gene expression signature associated with outcomes in hepatitis C cirrhosis and hepatocellular carcinoma after curative resection (2015) (101)
- Current Diagnosis & Treatment in Gastroenterology (2002) (100)
- Interleukin-6 protects hepatocytes from CCl4-mediated necrosis and apoptosis in mice by reducing MMP-2 expression. (2005) (99)
- Case definitions for inclusion and analysis of endpoints in clinical trials for nonalcoholic steatohepatitis through the lens of regulatory science (2017) (97)
- Mac the knife? Macrophages- the double-edged sword of hepatic fibrosis. (2005) (97)
- Precision-cut liver slices as a new model to study toxicity-induced hepatic stellate cell activation in a physiologic milieu. (2005) (96)
- The Power of Plasticity-Metabolic Regulation of Hepatic Stellate Cells. (2020) (93)
- IL-17A Enhances the Expression of Profibrotic Genes through Upregulation of the TGF-β Receptor on Hepatic Stellate Cells in a JNK-Dependent Manner (2014) (92)
- Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap (2018) (92)
- Cellular basis of hepatic fibrosis and its role in inflammation and cancer. (2013) (92)
- Is liver fibrosis reversible (2001) (90)
- Suppression of glioblastoma tumorigenicity by the Kruppel-like transcription factor KLF6 (2004) (89)
- Downregulation of hepatic stellate cell activation by retinol and palmitate mediated by adipose differentiation‐related protein (ADRP) (2010) (86)
- Downregulation of KLF6 is an early event in hepatocarcinogenesis, and stimulates proliferation while reducing differentiation. (2007) (86)
- Transcriptional regulation in hepatic stellate cells. (2001) (85)
- Granulocyte macrophage colony-stimulating factor is required for aortic dissection/intramural haematoma (2015) (85)
- Multiple variants in toll-like receptor 4 gene modulate risk of liver fibrosis in Caucasians with chronic hepatitis C infection. (2009) (84)
- Retinoids in cancer chemoprevention. (2004) (84)
- Autophagy fuels tissue fibrogenesis (2012) (83)
- Increased 9,13-di-cis-retinoic acid in rat hepatic fibrosis: implication for a potential link between retinoid loss and TGF-beta mediated fibrogenesis in vivo. (1999) (82)
- Functional inactivation of the KLF6 tumor suppressor gene by loss of heterozygosity and increased alternative splicing in glioblastoma (2007) (82)
- Mechanisms of nitric oxide interplay with Rho GTPase family members in modulation of actin membrane dynamics in pericytes and fibroblasts. (2005) (82)
- Lhx2-/- mice develop liver fibrosis. (2004) (81)
- In vivo regulation of p21 by the Kruppel-like factor 6 tumor-suppressor gene in mouse liver and human hepatocellular carcinoma (2007) (81)
- A pilot study of ultra-deep targeted sequencing of plasma DNA identifies driver mutations in hepatocellular carcinoma (2018) (81)
- Antifibrotic Therapies: Where Are We Now? (2016) (80)
- Advances in antifibrotic therapy (2008) (80)
- Contributions of metabolic dysregulation and inflammation to nonalcoholic steatohepatitis, hepatic fibrosis, and cancer (2014) (79)
- A histone deacetylase inhibitor, largazole, decreases liver fibrosis and angiogenesis by inhibiting transforming growth factor‐β and vascular endothelial growth factor signalling (2013) (79)
- Emerging and Disease-Specific Mechanisms of Hepatic Stellate Cell Activation (2015) (77)
- E-cadherin is a novel transcriptional target of the KLF6 tumor suppressor (2006) (74)
- The XBP1 Arm of the Unfolded Protein Response Induces Fibrogenic Activity in Hepatic Stellate Cells Through Autophagy (2016) (73)
- Therapeutic targeting of the PDGF and TGF-β-signaling pathways in hepatic stellate cells by PTK787/ZK22258 (2009) (72)
- The Krüppel‐like transcriptional factors Zf9 and GKLF coactivate the human keratin 4 promoter and physically interact (2000) (70)
- Phosphorylation of retinoid X receptor suppresses its ubiquitination in human hepatocellular carcinoma (2002) (69)
- CD11b+ Gr1+ bone marrow cells ameliorate liver fibrosis by producing interleukin‐10 in mice (2012) (67)
- Impaired dermal wound healing in discoidin domain receptor 2-deficient mice associated with defective extracellular matrix remodeling (2011) (67)
- Prevalence and Profile of Nonalcoholic Fatty Liver Disease in Lean Adults: Systematic Review and Meta‐Analysis (2020) (66)
- Loss of Matrix Metalloproteinase-2 Amplifies Murine Toxin-Induced Liver Fibrosis by Upregulating Collagen I Expression (2011) (65)
- Molecular mechanism for growth suppression of human hepatocellular carcinoma cells by acyclic retinoid. (2003) (65)
- The LATS2 tumor suppressor inhibits SREBP and suppresses hepatic cholesterol accumulation (2016) (65)
- β-Catenin signaling in hepatocellular cancer: Implications in inflammation, fibrosis, and proliferation. (2014) (64)
- A genomic and clinical prognostic index for hepatitis C-related early-stage cirrhosis that predicts clinical deterioration (2014) (64)
- Discoidin domain receptor 2 deficiency predisposes hepatic tissue to colon carcinoma metastasis (2011) (64)
- Antifibrotic Agents for Liver Disease (2006) (63)
- Transcriptional activation of the insulin-like growth factor I receptor gene by the Kruppel-like factor 6 (KLF6) tumor suppressor protein: potential interactions between KLF6 and p53. (2004) (62)
- Strategies and endpoints of antifibrotic drug trials: Summary and recommendations from the AASLD Emerging Trends Conference, Chicago, June 2014 (2015) (62)
- Hepatic fibrosis 2022: Unmet needs and a blueprint for the future (2021) (61)
- Prostaglandin E2 inhibits transforming growth factor β1-mediated induction of collagen α1(I) in hepatic stellate cells (2004) (61)
- Distinct from its canonical effects, deletion of IL-12p40 induces cholangitis and fibrosis in interleukin-2Rα(-/-) mice. (2014) (60)
- Glucokinase links Krüppel‐like factor 6 to the regulation of hepatic insulin sensitivity in nonalcoholic fatty liver disease (2012) (60)
- Antifibrotic Activity of Sorafenib in Experimental Hepatic Fibrosis: Refinement of Inhibitory Targets, Dosing, and Window of Efficacy In Vivo (2012) (59)
- Obesity, inflammatory signaling, and hepatocellular carcinoma-an enlarging link. (2010) (59)
- Molecular mechanisms of hepatic fibrosis and principles of therapy (1997) (59)
- Hepatitis Outreach Network: a practical strategy for hepatitis screening with linkage to care in foreign-born communities. (2013) (59)
- Early genes induced in hepatic stellate cells during wound healing. (1997) (59)
- Hepatic fibrosis and the microenvironment: fertile soil for hepatocellular carcinoma development. (2014) (59)
- Hepatic Fibrosis: Emerging Therapies (2015) (58)
- Genome-wide transcriptome analysis identifies novel gene signatures implicated in human chronic liver disease. (2013) (58)
- Functional role of the KLF6 tumour suppressor gene in gastric cancer. (2009) (56)
- Regulation of Kruppel-like factor 6 tumor suppressor activity by acetylation. (2005) (56)
- The virtuosity of hepatic stellate cells. (1999) (56)
- Evaluation of fibrosis and hepatitis C. (1999) (56)
- Loss of discoidin domain receptor 2 promotes hepatic fibrosis after chronic carbon tetrachloride through altered paracrine interactions between hepatic stellate cells and liver-associated macrophages. (2011) (55)
- Altered Microbiota Diversity and Bile Acid Signaling in Cirrhotic and Noncirrhotic NASH-HCC (2020) (55)
- Liver fibrosis in 2012: Convergent pathways that cause hepatic fibrosis in NASH (2013) (55)
- The In Ovo Chick Chorioallantoic Membrane (CAM) Assay as an Efficient Xenograft Model of Hepatocellular Carcinoma. (2015) (54)
- Hepatocyte Growth Factor Enhances Alternative Splicing of the Krüppel-like Factor 6 (KLF6) Tumor Suppressor to Promote Growth through SRSF1 (2012) (54)
- Improvement in liver histology due to lifestyle modification is independently associated with improved kidney function in patients with non‐alcoholic steatohepatitis (2017) (53)
- Treatment of hepatic fibrosis: Almost there (2003) (53)
- Human hepatic stellate cell line (LX-2) exhibits characteristics of bone marrow-derived mesenchymal stem cells. (2011) (53)
- Molecular diagnosis of chronic liver disease and hepatocellular carcinoma: the potential of gene expression profiling. (2006) (52)
- Vascular Injury Triggers Krüppel-Like Factor 6 Mobilization and Cooperation With Specificity Protein 1 to Promote Endothelial Activation Through Upregulation of the Activin Receptor-Like Kinase 1 Gene (2013) (52)
- Prospective comparison of magnetic resonance imaging to transient elastography and serum markers for liver fibrosis detection (2016) (52)
- Genomics and proteomics in liver fibrosis and cirrhosis (2012) (51)
- Molecular characterization of hepatocellular carcinoma in patients with non-alcoholic steatohepatitis. (2021) (51)
- Development and validation of a noninvasive prediction model for nonalcoholic steatohepatitis resolution after lifestyle intervention (2016) (51)
- Post-transcriptional activation of PPAR alpha by KLF6 in hepatic steatosis. (2013) (51)
- Regulation of hepatic stellate cell activation and growth by transcription factor myocyte enhancer factor 2. (2004) (51)
- Serum biomarkers can predict a change in liver fibrosis 1 year after lifestyle intervention for biopsy‐proven NASH (2017) (50)
- Aramchol in patients with nonalcoholic steatohepatitis: a randomized, double-blind, placebo-controlled phase 2b trial (2021) (50)
- Increased alternative splicing of the KLF6 tumour suppressor gene correlates with prognosis and tumour grade in patients with pancreatic cancer. (2008) (50)
- An Immune Gene Expression Signature Associated With Development of Human Hepatocellular Carcinoma Identifies Mice That Respond to Chemopreventive Agents. (2019) (50)
- Resistance to p53-mediated growth arrest and apoptosis in Hep 3B hepatoma cells (1997) (50)
- Immunomodulatory Effects of Lenvatinib Plus Anti–Programmed Cell Death Protein 1 in Mice and Rationale for Patient Enrichment in Hepatocellular Carcinoma (2021) (49)
- Parenchymal and nonparenchymal cell interactions in the liver. (1993) (48)
- Transcription factor KLF6 upregulates expression of metalloprotease MMP14 and subsequent release of soluble endoglin during vascular injury (2016) (48)
- Using Big Data to Discover Diagnostics and Therapeutics for Gastrointestinal and Liver Diseases. (2017) (48)
- p53 does not repress hypoxia-induced transcription of the vascular endothelial growth factor gene. (1997) (47)
- p38‐MAPK‐ and caspase‐3‐mediated superoxide‐induced apoptosis of rat hepatic stellate cells: Reversal by retinoic acid (2009) (47)
- Krüppel cripples prostate cancer: KLF6 progress and prospects. (2003) (46)
- Synergistic induction of apoptosis by acyclic retinoid and interferon‐β in human hepatocellular carcinoma cells (2002) (46)
- Nonalcoholic Steatohepatitis Is Associated With Increased Mortality in Obese Patients Undergoing Bariatric Surgery. (2016) (46)
- Hepatic fibrogenesis. (2018) (46)
- Transcriptional regulation of stellate cell activation (2006) (46)
- Genetic Characteristics of the Human Hepatic Stellate Cell Line LX-2 (2013) (45)
- Central Role of Conventional Dendritic Cells in Regulation of Bone Marrow Release and Survival of Neutrophils (2014) (45)
- Embryonic expression of Krüppel-like factor 6 in neural and non-neural tissues (2001) (45)
- Programmed cell death‐1 blockade enhances response to stereotactic radiation in an orthotopic murine model of hepatocellular carcinoma (2017) (45)
- Fibrogenic cell reversion underlies fibrosis regression in liver (2012) (44)
- Why do so many NASH trials fail? (2020) (44)
- Integrin alpha 11 in the regulation of the myofibroblast phenotype: implications for fibrotic diseases (2017) (43)
- Prevention of Rat Hepatocarcinogenesis by Acyclic Retinoid Is Accompanied by Reduction in Emergence of Both TGF-α-Expressing Oval-Like Cells and Activated Hepatic Stellate Cells (2005) (43)
- Carcinogen‐induced hepatic tumors in KLF6+/− mice recapitulate aggressive human hepatocellular carcinoma associated with p53 pathway deregulation (2011) (43)
- TGF-beta regulates the expression of transcription factor KLF6 and its splice variants and promotes co-operative transactivation of common target genes through a Smad3-Sp1-KLF6 interaction. (2009) (43)
- Diagnostic Modalities for Non-alcoholic Fatty Liver Disease (NAFLD), Non-alcoholic Steatohepatitis (NASH) and Associated Fibrosis (2017) (42)
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- 24 A NOVEL MOLECULAR CLASSIFICATION OF HCV-RELATED HEPATOCELLULAR CARCINOMA (HCC) BASED ON INTEGRATIVE GENOMIC ANALYSIS (2008) (2)
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- Abstract 2996: Overexpression of potential oncogenic microRNAs defines a new molecular subclass of hepatocellular carcinoma (2010) (2)
- Megatrends in bile acid receptor research (2017) (2)
- Abstract 16670: Anterior Myocardial Infarction and Low Ejection Fraction: Should We Anticoagulate? (2011) (2)
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- 507 APRI and FIB-4 Index Scores Can Enrich for Subjects With Fibrotic Non-Alcoholic Steatohepatitis (NASH) in Clinical Trials - The CENTAUR Trial Data (2016) (1)
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- 1136 REGRESSION OF FIBROSIS AND REVERSAL OF CIRRHOSIS IN THIOACETAMIDE-INDUCED LIVER FIBROSIS FOLLOWING TREATMENT WITH GALECTIN INHIBITORS (2013) (1)
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- Hepatic Autophagy Deficiency Compromises FXR Functionality and Causes Cholestatic Injury (2019) (0)
- Krüppel-like factor 6 is a transcriptional activator of autophagy in acute liver injury (2017) (0)
- Additional file 2 Figure S2 (2013) (0)
- KLF6-SV1 accelerates prostate cancer progression and metastasis (2008) (0)
- Senolytic CAR T cells reverse senescence-associated pathologies (2020) (0)
- DYSREGULATION OF TUMOR SUPPRESSOR KLF6 INCREASES HCC RELATED MORTALITY IN HCV INFECTED PATIENTS AND INCIDENCE OF TUMOR IN MOUSE MODEL OF HEPATIC CARCINOGENESIS (2009) (0)
- Interleukin-15 Receptor α on Hepatic Stellate Cells Controls Fibrogenesis In Murine Liver Injury (2016) (0)
- Identifying Patients With Nonalcoholic Steatohepatitis That Are Nonresponders to Therapy Reply (2016) (0)
- 51 Novel growth suppressor targets of the KLF6 tumor suppressor gene identified by stringent microarray analysis (2003) (0)
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- 881 COMBINATION THERAPY WITH EGFR1–2/VEGFR INHIBITOR (XL647) AND SORAFENIB IMPROVES OUTCOMES IN A PRE-CLINICAL MODEL OF HCC (2010) (0)
- 216 Targeted and regulable expression of transgenes in hepatic stellate cells using an adenoviral CRE-loxp system (2003) (0)
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- Cell Death and Autophagy in Hepatic Stellate Cell Activation and Function (2017) (0)
- Publisher Correction: SOX9 regulated matrix proteins are increased in patients serum and correlate with severity of liver fibrosis (2019) (0)
- OL-085 A candidate genes study for the association of host single nucleotide polymorphisms with liver cirrhosis risk in Chinese hepatitis B patients (2011) (0)
- 379 Antifibrotic activity of refanlin, a hepatocyte growth factor analogue in vitro and in experimental liver fibrosis (2003) (0)
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- TGF-β regulates expression of KLF6 and its splice variants, and promotes cooperative transactivation of common target genes through a Smad3/Sp1/KLF6 interaction (2009) (0)
- A Decade of Model for End-Stage Liver Disease (MELD): Is it Time to Uncap the MELD? Initial Single-Center Experience in the United States with Early Liver Transplantation for Severe Alcoholic Hepatitis (2013) (0)
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- Prospective Comparison of IVIM DWI, MR Elastography and Transient Elastography for the detection of liver fibrosis in HCV. Initial results (2012) (0)
- Antifibrotic targets and therapy in HCV (2005) (0)
- A single nucleotide polymorphism of DDX5 that confers more rapid fibrosis progression is associated with reduced transcriptional repression of key fibrogenic genes in hepatic stellate cells (2008) (0)
- Acetylation status of KLF6 regulates its transactivation of p21 and may be a key determinant of hepatocellular growth (2001) (0)
- Survival of Neutrophils in Regulation of Bone Marrow Release and Central Role of Conventional Dendritic Cells (2014) (0)
- Hepatic Fibrosis; Noninvasive Diagnostics and Treatment Strategies (2007) (0)
- The peroxisomal transporter ABCD3 plays a major role in dicarboxylic fatty acid metabolism (2021) (0)
- Human Hepatic Stellate Cells Carry a New Splice Variant of the Human ADAMTS13 (2008) (0)
- Mechanisms of NAFLD development and therapeutic strategies (2018) (0)
- Transcription factor KLF6 upregulates gene expression of metaloprotease MMP-14 and soluble endoglin release upon vascular injury (2015) (0)
- CYP2E1-mediated oxidative stress induces COL1A2 mRNA in hepatic stellate cells and in a coculture system of HepG2 and stellate cells (1999) (0)
- SAT-234-Risk of hepatocellular carcinoma and efficacy of direct-acting antivirals in patients with concurrent hepatitis C virus (2019) (0)
- Development and Validation of a Non-Invasive Model for Predicting Fibrosis Resolution One Year after Lifestyle Intervention for Biopsy-Proven Non-Alcoholic Steatohepatitis (2016) (0)
- [202] SELECTIVE LONG-TERM ACTIVATION OF CANNABINOID CB RECEPTORS REDUCES HEPATIC FIBROSIS IN CIRRHOTIC RATS WITH ASCITES (2007) (0)
- Abstract 4718: Potent preclinical antitumor effects induced by pan-histone deacetylase inhibitor panobinostat in combination with sorafenib in hepatocellular carcinoma (2012) (0)
- Liver-specific deletion of KLF6 uncovers novel transcriptional pathways linked to lipid and glucose homeostasis (2010) (0)
- Genome-wide identification of miRNA binding-sites in primary human hepatic stellate cells IL-1 signaling regulates bile duct injury and obstruction in biliary atresia (2014) (0)
- What Are the Best Diagnostic Modalities for Non-alcoholic Fatty Liver Disease, Nonalcoholic Steatohepatitis and Associated Fibrosis? A Summary of AALSD Trend Conference in NASH (154/120) (2020) (0)
- Links from fibrosis to hepatocellular carcinoma (2013) (0)
- Chapter 7 – Liver fibrogenesis: Mechanisms and clinical relevance (2017) (0)
- Thomas D. Boyer, MD (1943-2018). (2018) (0)
- Genome-wide transcriptome analysis identifies novel gene signatures implicated in human chronic liver disease (2013) (0)
- Upregulation of Krüppel-Like Factor 6 is associated with acute liver injury in mice and humans (2015) (0)
- Reefer madness? Assessing the effects of cannabinoids with a less jaundiced eye. (2007) (0)
- 371 ENDOPLASMIC RETICULUM STRESS ACTIVATES HEPATIC STELLATE CELLS THROUGH AUTOPHAGIC SIGNALING (2012) (0)
- Artemisia capillaris Thunb. inhibits cell growth and induces apoptosis in human hepatic stellate cell line LX2 (2010) (0)
- Additional file 1 Figure S1 (2013) (0)
- Sa1606 Effect of Liver Progenitor Cells on Hepatic Stellate Cells (2016) (0)
- Hepatitis C virus infected apoptotic cells (bodies) differentially activate hepatic Stellate cells as compared to non-infected apoptotic bodies (2006) (0)
- Abstract P-542: HEAT STRESS INDUCED PERI-MYOCARDITIS DUE TO A NOVEL MUTATION IN HIKESHI NUCLEAR IMPORT CARRIER OF HEAT SHOCK PROTEIN 70 (2018) (0)
- Early identification of patients with acute myocardial infarction: The utility of a new rapid quantitative assay for serum myoglobin (1994) (0)
- KLF6 POLYMORPHISM IN PROSTATE CANCER REVEALS A NOVEL MECHANISM OF TUMOR SUPPRESSOR GENE INACTIVATION. (2003) (0)
- 66 SERUM LEVELS OF THE PRO-INFLAMMATORY CYTOKINE HMGB1 CORRELATE WITH VAGUS NERVE ACTIVITY. (2004) (0)
- Physical interaction between the kruppel-like transcriptional factors Zf9/KLF6 and GKLF/KLF4 and its effect on the human keratin 4 promoter (2000) (0)
- RESPIR ATORY EDITORIAL BOARD (2015) (0)
- Sterilization of contaminated burrs. (1994) (0)
- Introduction to the Symposium (1994) (0)
- Association of HSD17B13 and PNPLA3 with liver enzymes and fibrosis in Hispanic/Latino individuals of diverse genetic ancestries. (2023) (0)
- Shared and Tissue-Specific Genetic Features of Primary Myelofibrosis, Hepatic Fibrosis, Idiopathic Pulmonary Fibrosis and Kidney Fibrosis (2017) (0)
- P0990 : Non-alcoholic steatohepatitis is an independent predictor of mortality in a cohort of 493 morbidly obese patients undergoing bariatric surgery (2015) (0)
- Commentary Kruppel Cripples Prostate Cancer KLF6 Progress and Prospects (2003) (0)
- D-Dimer Correlates with Development and Activity of Pulmonary Fibrosis (2020) (0)
- KLF6 INTERACTS WITH FXR TARGET GENES AND EFFECTS THE OUTCOME OF PRIMARY SCLEROSING CHOLANGITIS (2019) (0)
- 110 MOLECULAR AND CLINICAL CHARACTERIZATION OF RICTOR (MTORC2) AS A CANDIDATE ONCOGENE IN HEPATOCELLULAR CARCINOMA (2009) (0)
- Secreted folate receptor-gamma drives fibrogenesis in nonalcoholic steatohepatitis by amplifying TGFβ signaling in hepatic stellate cells (2022) (0)
- Abstract 18872: Kruppel-like Factor 6 Promotes Obesity and Glucose Intolerance Through Adipocyte Differentiation (2012) (0)
- Corrigendum to: "Impaired endothelial autophagy promotes liver fibrosis by aggravating the oxidative stress response during acute liver injury" [J Hepatol (2019) 458-469]. (2020) (0)
- 266 Evidence of hedgehog signaling pathway activation in hepatocellular carcinoma (2006) (0)
- Tracking HCC pathogenesis but not the tumor cells after biopsy. (2014) (0)
- 155. Tumor Necrosis In Vivo Caused by a Novel Combination of Sorafenib and Rapamycin: Targeting the RAS and Motor Pathways ION Hepatocellular Carcinoma (2008) (0)
- A physician-scientist’s wish list for the 2016 U.S. presidential candidates (2016) (0)
- Focus. An emerging conceptual scaffold for NASH. (2012) (0)
- HSC Activation and Retinoid Metabolism (2001) (0)
- Gene expression profiles of pre-neoplastic lesions and hepatocellular carcinoma in hepatitis C virus -cirrhotic patients (2005) (0)
- Preface to BBA issue devoted to fibrosis. (2013) (0)
- Abstract 15847: Kruppel-Like Factor 6 (KLF6) Regulates Obesity and Glucose Intolerance (2011) (0)
- Spermidine Supplementation Protects the Liver Endothelium from Liver Damage in Mice (2021) (0)
- Characterisation of hepatic lipocyte type IV collagenase/gelatinase (1989) (0)
- END-STAGE LIVER DISEASE Bone marrow suppression Deteriorated liver function Portal hypertension TPO Splenic sequestration Plasma expansion Platelet production Platelet destruction Thrombocytopenia with platelets in liver FIBROGENESIS (2011) (0)
- ORIGINAL ARTICLES—LIVER, PANCREAS, AND BILIARY TRACT Transplantation Trends in Primary Biliary Cirrhosis (2007) (0)
- and activated hepatic stellate cells IL-10 receptor and coreceptor expression in quiescent (2005) (0)
- Ergocalciferol significantly inhibits profibrogenic and proinflammatory gene expression by hepatic stellate cells: Ergocalciferol a potential supplement in the therapy of liver fibrosis (2010) (0)
- NCytoskeleton of Liver Perisinusoidal Cells (Lipocytes) in Normal and Pathological Conditions (2004) (0)
- Scarring in Alcoholic Liver Disease (1997) (0)
- An integrated view of anti-inflammatory and antifibrotic targets for the treatment of NASH. (2023) (0)
- 211: OUTCOMES IN INFANTS BORN TO MOTHERS WITH AND WITHOUT NON-ALCOHOLIC FATTY LIVER DISEASE (2022) (0)
- Activin Receptor-Like Kinase 1 Gene Specificity Protein 1 to Promote Endothelial Activation Through Upregulation of the Vascular Injury Triggers Krüppel-Like Factor 6 Mobilization and Cooperation With (2012) (0)
- Hepatic stellate cells maintain liver homeostasis through paracrine neurotrophin-3 signaling (2023) (0)
- β‐Catenin and HCC phenotype in mice and men (2013) (0)
- Principles on the path to a hepatologist's enlightenment (2015) (0)
- current as in a JNK-Dependent Manner Receptor on Hepatic Stellate Cells β the TGF-Profibrotic Genes through Upregulation of IL-17 A Enhances the Expression of H . (2014) (0)
- Inhibition of P53-mediated apoptosis by BCL-XL endogenously expressed in human hepatocellular carcinoma (2000) (0)
- Signaling and Regulation Hepatocyte Growth Factor Enhances Alternative Splicing of the Kr € uppel-like Factor 6 ( KLF 6 ) Tumor Suppressor to Promote Growth Though SRSF (2012) (0)
- 1274 MEF2 regulates hepatic stellate cell activation and growth (2003) (0)
- Reply: (2005) (0)
- FORMES ALTERNATIVES D'EPISSURE DE KLF6 ET POLYMORPHISME D'ADN DE KLF6 DE CELLULES GERMINALES ASSOCIES A UN RISQUE ACCRU DE CANCER (2005) (0)
- 915 INTRIGUING RELATIONSHIP BETWEEN VITAMIN D AND LIVER FIBROSIS (2010) (0)
- Abstract #444: Molecular and clinical characterization of RICTOR (MTORC2) as a candidate oncogene in hepatocellular carcinoma (2009) (0)
- Receptor tyrosine kinase expression, a central component of rat hepatic stellate cell activation - characterization by homology PCR (1995) (0)
- Role of hepatic stellate cells in liver tumor angiogenesis (2002) (0)
- The future of hepatology. (2023) (0)
- MOLECULAR MECHANISMS OF HSC ACTIVATION AND ECM ACCUMULATION (2001) (0)
- 114 AUTOPHAGY: A NOVEL REGULATOR OF HEPATIC STELLATE CELL ACTIVATION AND FIBROGENESIS (2011) (0)
- First Amendment and "Foreign-Controlled" U.S. Corporations: Why Congress Ought to Affirm Domestic Subsidiaries' Corporate Political-Speech Rights (2013) (0)
- Transcriptional Regulation by KLF6, A Novel Tumor Suppressor Gene in Prostate Cancer, Through Interaction with HATS and HDACS (2006) (0)
- Treatment Targets and Therapeutic Regimens for Non-alcoholic Fatty Liver Disease (NAFLD) and Non-alcoholic Steatohepatitis (NASH): A Summary of AALSD Trend Conference in NASH (2020) (0)
- University of Groningen Krüppel-like factor 6 is a transcriptional activator of autophagy in acute liver injury (2017) (0)
- The future of hepatology: Embrace change (2015) (0)
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