Scott Sieburth
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American chemist
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Chemistry
Scott Sieburth's Degrees
- PhD Chemistry University of California, Berkeley
- Bachelors Chemistry University of California, Berkeley
Why Is Scott Sieburth Influential?
(Suggest an Edit or Addition)According to Wikipedia, Scott McNeill Sieburth is an American chemist. Sieburth's parents were the librarian Janice Fae Boston and the biologist John McNeill Sieburth. Sieburth completed a Bachelor of Science degree at Worcester Polytechnic Institute in 1977, and obtained a doctorate from Harvard University in 1983. He is a professor at Temple University. He was elected a fellow of the American Chemical Society in 2010.
Scott Sieburth's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Silicon-based metalloprotease inhibitors: synthesis and evaluation of silanol and silanediol peptide analogues as inhibitors of angiotensin-converting enzyme. (2002) (120)
- Silanediol Protease Inhibitors: From Conception to Validation (2006) (113)
- Intramolecular Reactions of Temporarily Silicon-Tethered Molecules (1997) (112)
- Silanediols: A New Class of Potent Protease Inhibitors. (1998) (81)
- Drug design with a new transition state analog of the hydrated carbonyl: silicon-based inhibitors of the HIV protease. (2001) (62)
- The [4 + 4] cycloaddition and its strategic application in natural product synthesis (1996) (60)
- Macroexpansion methodology : Medium ring synthesis based on an eight unit ring expansion process (1981) (50)
- Silanol synthesis: reaction of hexaphenylcyclotrisiloxane with organometallic reagents (1993) (49)
- Silanediol inhibitors of angiotensin-converting enzyme. Synthesis and evaluation of four diastereomers of Phe[Si]Ala dipeptide analogues. (2005) (46)
- Practical method for .alpha.-alkenyl ketone synthesis based on a facile reductive rearrangement of alkynyl halohydrins (1983) (44)
- Structural analysis of silanediols as transition-state-analogue inhibitors of the benchmark metalloprotease thermolysin. (2005) (39)
- An intramolecular Diels-Alder reaction of vinylsilanes (1992) (38)
- Efficient, enantioselective assembly of silanediol protease inhibitors. (2011) (36)
- Serine protease inhibition by a silanediol peptidomimetic. (2012) (35)
- Enantioselective α-Silyl Amino Acid Synthesis by Reverse-Aza-Brook Rearrangement (2003) (34)
- A silanediol inhibitor of the metalloprotease thermolysin: synthesis and comparison with a phosphinic acid inhibitor. (2004) (34)
- Asymmetric synthesis of alpha-amino allyl, benzyl, and propargyl silanes by metalation and rearrangement. (2003) (32)
- Post-Ugi Cascade Transformations for Accessing Diverse Chromenopyrrole Collections. (2018) (30)
- Silanol reactivity : evaluation of silanolate as a metalation-directing group (1993) (29)
- Organosilane insecticides. Part I: Biological and physical effects of isosteric replacement of silicon for carbon in etofenprox and MTI‐800 (1990) (27)
- A photochemical [4 + 4] method for the construction of annulated eight-membered rings (1991) (25)
- Synthesis and properties of a sterically unencumbered δ-silanediol amino acid. (2012) (24)
- Multidirectional desymmetrization of pluripotent building block en route to diastereoselective synthesis of complex nature-inspired scaffolds (2018) (23)
- Fusicoccin Ring System by [4 + 4] Cycloaddition. Control of Diastereoselectivity through Hydrogen Bonding (1998) (22)
- Tetraquinanes via [4 + 4] photocycloaddition/transannular ring closure. (2010) (22)
- α-Trialkylsilyl Amino Acid Stability (2005) (21)
- Enyne [4 + 4] photocycloaddition: bridged 1,2,5-cyclooctatrienes. (2010) (20)
- Studies in bicyclo[3.1.0]hexane methanolysis. Ring opening of activated cyclopropanes under acidic and basic conditions. (2002) (19)
- Silanediol peptidomimetics. Evaluation of four diastereomeric ACE inhibitors. (2004) (18)
- Intramolecular [4 + 4] photocycloaddition of 2-pyridones tethered by a three-carbon chain: studies on the formation of cycloadducts and control of stereogenesis. 3 (1994) (18)
- Photoreactivity of 2-pyridones with furan, benzene, and naphthalene. Inter- and intramolecular photocycloadditions. (2000) (18)
- Sequencing [4+1]-Cycloaddition and Aza-Michael Addition Reactions: A Diastereoselective Cascade for the Rapid Access of Pyrido[2',1':2,3]/Thiazolo[2',3':2,3]imidazo[1,5-a]quinolone Scaffolds as Potential Antibacterial and Anticancer Motifs. (2019) (17)
- Efficient asymmetric synthesis of silanediol precursors from 1,5-dihydrosiloles. (2007) (17)
- Stereocontrol of 2-Pyridone [4 + 4] Photocycloaddition: A Thermal-Photochemical Cycle To Produce Exclusively Trans Cycloadducts (1994) (16)
- α-Alkyl-α-aminosilanes. 1. Metalation and alkylation between silicon and nitrogen (1996) (16)
- Intramolecular pyridone/enyne photocycloaddition: partitioning of the [4 + 4] and [2 + 2] pathways. (2011) (15)
- Polyquinanes by [4 + 4] cycloaddition-transannular cyclization. (2001) (15)
- MACROEXPANSION METHODOLOGY: AN EFFICIENT EIGHT UNIT RING EXPANSION (1981) (15)
- A [4 + 4] 2-pyridone approach to taxol. 3. Stereocontrol during elaboration of the cyclooctane. (2000) (14)
- Distributed Heuristic Synthesis Search (1998) (14)
- A 2-PYRIDONE PHOTO-4 + 4 APPROACH TO THE TAXANES (1996) (14)
- Enyne-2-pyrone [4 + 4]-Photocycloaddition: Sesquiterpene Synthesis and a Low-Temperature Cope Rearrangement. (2015) (14)
- Selective Intermolecular Photo-[4 + 4]-cycloaddition with 2-Pyridone Mixtures. 2. Preparation of (1α,2β,5β,6α)-3-Butyl- 9-methoxy-3,7-diazatricyclo[4.2.2.22,5]dodeca-9,11-diene-4,8-dione (1999) (13)
- Synthesis of α-alkyl-α-aminosilanes by rhodium-catalyzed hydrosilylation of Boc-protected vinyl amines (2000) (13)
- A Practical Synthesis of Difunctional Organosilane Reagents and Their Application to the Diels-Alder Reaction. (1999) (12)
- Solvent-dependent stereoselectivity of bis-2-pyridone [4 + 4] photocycloaddition is due to H-bonded dimers. (1999) (11)
- Organosilane insecticides. Part II: Chemistry and structure—activity relationships (1990) (11)
- Novel reaction pathways for 2-pyridone [4+4] photoadducts. (2006) (11)
- 3-4'-Bipiperidines via sequential [4 + 4]-[3,3]-retro-Mannich reactions. (2009) (10)
- ?-Alkyl-?-aminosilanes: Synthesis via Alkylation and Hydrosilylation (1997) (10)
- Asymmetric Synthesis of Silanediol Inhibitors for the Serine Protease Coagulation Cascade Enzyme FXIa. (2018) (10)
- An enolate-accelerated Cope rearrangement (1985) (9)
- Carbocyclic Amino Ketones by Bredt's Rule-Arrested Kulinkovich-de Meijere Reaction. (2016) (9)
- α-Alkyl-α-aminosilanes. 2. A2H NMR study of organolithium stabilization by silicon and by phenyl in solution (1996) (9)
- Drug development post COVID-19 pandemic: toward a better system to meet current and future global health challenges (2020) (9)
- Fusicoccin Synthesis by Intramolecular [4+4] Photocycloaddition of 2-Pyridones: Stereocontrol of the Cycloaddition and Elaboration of the Pentacyclic Product (2001) (9)
- Formation and isomerization of polycyclic 1,5-enynes ☆ (2015) (8)
- A short synthesis of the tricyclo[3.3.21,4.0]decane ring system (1994) (8)
- Enyne [4 + 4] photocycloaddition with polycyclic aromatics (2014) (8)
- The BC rings of taxol by [4+4] photocycloaddition (1994) (8)
- Photocycloaddition of four-carbon-tethered pyridones. Intramolecular hydrogen bonding and facilitated amide hydrolysis by a proximal secondary alcohol. (2002) (8)
- Intermolecularly selective [4+4] photocycloaddition of 2-pyridone mixtures (1996) (8)
- New insecticides by replacement of carbon by other Group IV elements (1990) (8)
- Fusicoccin ring system by [4+4] cycloaddition. 2. A model study (1999) (8)
- A practical, two-step synthesis of 2-substituted 1,3-butadienes. (2009) (7)
- Enyne [4+4] Cycloaddition/Oxidation: Ring Contraction via Cyclopropanones and Their Anionic Ring-Opening Reactions. (2017) (7)
- Divergent Strategy for Diastereocontrolled Synthesis of Small- and Medium-Ring Architectures. (2020) (7)
- Diastereoselectivity during 2-pyridone photo-[4+4] cycloaddition. The tribenzylsilyl protecting group (2001) (7)
- Evidence for helicity in insect diuretic peptide hormones: computational analysis, spectroscopic studies, and biological assays. (1999) (7)
- β-Peptide coatings by surface-initiated polymerization. (2012) (6)
- Intramolecular photocycloaddition of 1,3-dienes with 2-pyridones (1999) (6)
- Intramolecular [4 + 4] photocycloadditions: substituent-mediated product control (1993) (6)
- Photo-[4+4]-cycloaddition ( para ) of meta -substituted benzenes with 2-pyridones (2015) (6)
- TANDEM ASYMMETRIC ALKYLATION-DIECKMANN CONDENSATION (1995) (6)
- Pyridone annulation by 4 + 2 coupling of dienolates with nitriles and nitrile equivalents. A solution to the acetonitrile problem. (2001) (5)
- Tether-enforced reversal of regioselectivity: head-to-head [4 + 4] photocycloaddition of 2-pyridones (1996) (5)
- Studies in silanol synthesis: internal nucleophiles and steric hindrance (2001) (5)
- Silicon Mimics of Unstable Carbon (2014) (5)
- Stereoselective Late-Stage Transformations of Indolo[2,3-a]quinolizines Skeleta to Nature-Inspired Scaffolds. (2021) (5)
- Stabilization, isomerization and rearrangement of enyne [4 + 4]-cycloadducts. (2014) (5)
- A New β-Keto Amide Synthesis (2002) (4)
- Selective Intermolecular Photo-[4 + 4]-cycloaddition with 2-Pyridone Mixtures. 3. Synthetic Transformations of the Trans Cross-Product (1alpha,2beta,5beta,6alpha)-3-Butyl-9- methoxy-3,7-diazatricyclo[4.2.2.2(2,5)]dodeca-9,11-diene-4,8-dione. (1999) (4)
- Isosteric Replacement of Carbon with Silicon in the Design of Safer Chemicals (1997) (4)
- Boat versus half-chair cyclohexyl rings: determinants of conformational preference (1994) (4)
- Asymmetry by electrophilic rearrangement of symmetric 2-pyridone photodimers. (2005) (4)
- The Inter- and Intramolecular [4 + 4] Photocycloaddition of 2-Pyridones and Its Application to Natural Product Synthesis (1999) (3)
- Alpha-amino silanes via metalated imines as an approach to the synthesis of silanediol protease inhibitors (2013) (3)
- Photochemical Reactivity of Pyridones (2004) (3)
- Bioactive Amino Acids, Peptides and Peptidomimetics Containing Silicon (2014) (3)
- Beyond the medium ring: A [4 + 4] cycloaddition/fragmentation synthesis of eleven-membered rings (1997) (3)
- Stereoselective synthesis of hydroxylated bifenthrin isomers (1992) (2)
- Highly efficacious non-ester pyrethroid insecticides with low toxicity to fish. (1992) (2)
- Intramolecular Reactions of Temporarily Silicon‐Tethered Molecules (1998) (2)
- 1,4-Diaryl-1-cyclopropylbutanes: Highly Efficacious Insecticides with Low Fish Toxicity (1992) (2)
- Silanediol‐Based Inhibitor of Thermolysin. (2003) (2)
- A Quantitative NMR Method for Silyllithium Analysis (2017) (1)
- Insecticidal 1-Cyclopropyl-1,4-diarylbutenes and 1,4-Diarylbutanes (1995) (1)
- Photocycloaddition of Alkenes (Dienes) to Dienes ([4+2]/[4+4]) (2004) (1)
- A 2-Pyridone Photo-(4 + 4) Approach to the Taxanes. (1997) (1)
- Enantioselective alpha-silyl amino acid synthesis by reverse-aza-Brook rearrangement. (2003) (1)
- 2‐Alkenyl Carbinols from 2‐Halo Ketones: 2‐E‐Propenylcyclohexanol (2003) (1)
- Intramolecular (4 + 4) Photocycloaddition of 2-Pyridones Tethered by a Three-Carbon Chain: Studies on the Formation of Cycloadducts and Control of Stereogenesis. Part 3. (1994) (1)
- A Practical Synthesis of Difunctional Organosilane Reagents and Their Application to the Diels—Alder Reaction. (1999) (1)
- A Short Synthesis of the Tricyclo(3.3.21,4.0)decane Ring System. (1995) (1)
- Asymmetric Synthesis of α-Amino Allyl, Benzyl, and Propargyl Silanes by Metalation and Rearrangement. (2003) (1)
- An Intramolecular Diels‐Alder Reaction of Vinylsilanes. (1993) (0)
- Pyridone Annulation by [4 + 2] Coupling of Dienolates with Nitriles and Nitrile Equivalents. A Solution to the Acetonitrile Problem. (2002) (0)
- PRACTICAL METHOD FOR α‐ALKENYL KETONE SYNTHESIS BASED ON A FACILE REDUCTIVE REARRANGEMENT OF ALKYNYL HALOHYDRINS (1983) (0)
- Selective Intermolecular Photo-[4 + 4]-cycloaddition with 2-Pyridone Mixtures. 2. Preparation of (1alpha,2beta,5beta,6alpha)-3-Butyl- 9-methoxy-3,7-diazatricyclo[4.2.2.2(2,5)]dodeca-9,11-diene-4,8-dione. (1999) (0)
- Novel 1-Cyclopropyl-1-(4-substituted phenyl)-4-cyano-(4-fluoro-3-phenoxyphenyl)butane Insecticides (1995) (0)
- α-Alkyl-α-aminosilanes: Synthesis via Alkylation and Hydrosilylation (2010) (0)
- A New β‐Keto Amide Synthesis. (2003) (0)
- α‐Alkyl‐α‐aminosilanes. Part 1. Metalation and Alkylation Between Silicon and Nitrogen. (1996) (0)
- Crystal Structure of a Silanediol Protease Inhibitor Bound to Thermolysin (2006) (0)
- Tether‐Enforced Reversal of Regioselectivity: Head‐to‐Head (4 + 4) Photocycloaddition of 2‐Pyridones. (1997) (0)
- Intermolecularly Selective (4 + 4) Photocycloaddition of 2-Pyridone Mixtures. (1996) (0)
- Correction: Enyne [4 + 4] photocycloaddition with polycyclic aromatics (2015) (0)
- Stereocontrol of 2-Pyridone (4 + 4) Photocycloaddition: A Thermal- Photochemical Cycle to Produce Exclusively Trans Cycloadducts. (1994) (0)
- The (4 + 4) Cycloaddition and Its Strategic Application in Natural Product Synthesis (1996) (0)
- A SHORT SYNTHESIS OF THE TRICYCLO3.3.21,4.0DECANE RING SYSTEM (1994) (0)
- α-Alkyl-α-aminosilanes. Part 2. A 2H NMR Study of Organolithium Stabilization by Silicon and by Phenyl in Solution. (1996) (0)
- ALPHA -ALKYL-ALPHA -AMINOSILANES. 1. METALATION AND ALKYLATION BETWEEN SILICON AND NITROGEN (1996) (0)
- 2,2,2‐Trichloro‐t‐butoxycarbonyl Chloride (2001) (0)
- An intramolecular Diels-Alder reaction of vinylsilanes. [Erratum to document cited in CA117(15):151058k] (1993) (0)
- 2‐Methyl‐1‐propenyl Trifluoromethanesulfonate (2001) (0)
- Multidirectional desymmetrization of pluripotent building block en route to diastereoselective synthesis of complex nature-inspired scaffolds (2018) (0)
- Chemistry of Silicon‐Containing Amino Acids (2010) (0)
- Divergent Protocol for the Synthesis of Isoquinolino[1,2-b]quinazolinone and Isoquinolino[2,1-a]quinazolinone Derivatives. (2023) (0)
- Synthesis of α-Alkyl-α-aminosilanes by Rhodium-Catalyzed Hydrosilylation of Boc-Protected Vinyl Amines. (2001) (0)
- The BC Rings of Taxol by (4 + 4) Photocycloaddition. (1994) (0)
- Intramolecular Reactivity of trans [4+4] Photodimers of 2-Pyridones (2007) (0)
- Studies in Silanol Synthesis: Internal Nucleophiles and Steric Hindrance. (2001) (0)
- Macroexpansion Methodology. Part 5. An Enolate‐Accelerated Cope Rearrangement. (1986) (0)
- Tandem Asymmetric Alkylation-Dieckmann Condensation. (1996) (0)
- A Photochemical (4 + 4) Method for the Construction of Annulated Eight‐ Membered Rings. (1992) (0)
- Carbocyclic Amino Ketones by Bredt′s Rule-Arrested Kulinkovich-de Meijere Reaction. (2016) (0)
- Diastereoselective Synthesis of Camptothecin‐like Scaffolds: Construction of a New Class of Pseudo‐Natural Products (2023) (0)
- Practical Synthesis of Ambiphilic Silyl Intermediates (2008) (0)
- Unraveling the stereochemically rich 2-pyridone [4+4] photodimer (2010) (0)
- Book Review:Aspartic Proteinases: Retroviral and Cellular Enzymes Michael N. G. James (1999) (0)
- Alpha-trialkylsilyl amino acid stability. (2005) (0)
- MACROEXPANSION METHODOLOGY. PART 2. MEDIUM-RING SYNTHESIS BASED ON AN EIGHT-UNIT RING-EXPANSION PROCESS (1982) (0)
- CCDC 170720: Experimental Crystal Structure Determination (2001) (0)
- Cover Picture: Silanediol Protease Inhibitors: From Conception to Validation (Eur. J. Org. Chem. 2/2006) (2006) (0)
- Fusicoccin Ring System by [4 + 4] Cycloaddition. Control of Diastereoselectivity Through Hydrogen Bonding. (2010) (0)
- CCDC 170721: Experimental Crystal Structure Determination (2001) (0)
- Panel Discussion: Role of Biochemical, Physiological, and Neurochemical Research in the Insecticide Discovery Process (1987) (0)
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