Sekar Kathiresan

Q: What Schools Are Affiliated With Sekar Kathiresan

Sekar Kathiresan is affiliated with the following schools: Stanford University, Lund University, Queen Mary University of London, Cleveland State University, Massachusetts General Hospital, University of Pennsylvania, Harvard University, University of Western Ontario, University of Lübeck, Boston University, Université de Montréal, Jackson State University

Sekar Kathiresan's AcademicInfluence.com Rankings

Sekar Kathiresan

Philosophy

#6388

World Rank

#9419

Historical Rank

Logic

#3563

World Rank

#4746

Historical Rank

philosophy Degrees

Sekar Kathiresan

Biology

#8686

World Rank

#11803

Historical Rank

Genetics

#873

World Rank

#968

Historical Rank

biology Degrees

Download Badge

Philosophy
Biology

Sekar Kathiresan's Degrees

Doctorate Medicine Harvard University
PhD Genetics Harvard University

Why Is Sekar Kathiresan Influential?

(Suggest an Edit or Addition)

(See a Problem?)

Sekar Kathiresan's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Genetic studies of body mass index yield new insights for obesity biology (2015) (3549)
Biological, Clinical, and Population Relevance of 95 Loci for Blood Lipids (2010) (3485)
Age-related clonal hematopoiesis associated with adverse outcomes. (2014) (2967)
Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels (2007) (2888)
Discovery and Refinement of Loci Associated with Lipid Levels (2013) (2475)
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index (2010) (2011)
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study (2012) (2002)
Hundreds of variants clustered in genomic loci and biological pathways affect human height (2010) (1961)
Genetic Variants in Novel Pathways Influence Blood Pressure and Cardiovascular Disease Risk (2011) (1928)
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes (2012) (1839)
Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (2018) (1716)
A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease (2015) (1567)
Large-scale association analysis identifies new risk loci for coronary artery disease (2012) (1507)
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans (2008) (1392)
Common variants at 30 loci contribute to polygenic dyslipidemia (2009) (1380)
Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease (2017) (1358)
Genome-wide association study identifies eight loci associated with blood pressure (2009) (1225)
Association analyses of 249,796 individuals reveal eighteen new loci associated with body mass index (2010) (1179)
Genome-wide meta-analyses identify multiple loci associated with smoking behavior (2010) (1107)
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants (2009) (1100)
From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus (2010) (1048)
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility (2014) (933)
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease (2011) (894)
Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores. (2015) (858)
Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease. (2016) (847)
Visceral and Subcutaneous Adipose Tissue Volumes Are Cross-Sectionally Related to Markers of Inflammation and Oxidative Stress: The Framingham Heart Study (2007) (841)
Loss-of-function mutations in APOC3, triglycerides, and coronary disease. (2014) (799)
Common variants associated with plasma triglycerides and risk for coronary artery disease (2013) (767)
Identification of seven loci affecting mean telomere length and their association with disease (2013) (761)
Genetic associations with valvular calcification and aortic stenosis. (2013) (723)
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits (2018) (659)
Exome sequencing, ANGPTL3 mutations, and familial combined hypolipidemia. (2010) (630)
Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia. (2016) (630)
Testing for an Unusual Distribution of Rare Variants (2011) (595)
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture (2013) (568)
Searching for missing heritability: Designing rare variant association studies (2014) (564)
Polymorphisms associated with cholesterol and risk of cardiovascular events. (2008) (561)
HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials (2015) (559)
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium (2009) (551)
Meta-analysis identifies six new susceptibility loci for atrial fibrillation (2012) (535)
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study (2015) (532)
A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses (2010) (531)
Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials (2015) (515)
Rare and low-frequency coding variants alter human adult height (2016) (511)
New susceptibility locus for coronary artery disease on chromosome 3q22.3 (2009) (510)
The Metabochip, a Custom Genotyping Array for Genetic Studies of Metabolic, Cardiovascular, and Anthropometric Traits (2012) (506)
Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies (2011) (490)
Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia (2010) (455)
Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease (2016) (434)
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk (2017) (428)
Exome-wide association study of plasma lipids in >300,000 individuals (2017) (428)
Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction (2014) (426)
Multi-ethnic genome-wide association study for atrial fibrillation (2018) (425)
Concept, Design and Implementation of a Cardiovascular Gene-Centric 50 K SNP Array for Large-Scale Genomic Association Studies (2008) (416)
Mendelian Randomization. (2017) (413)
Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis (2012) (411)
FTO genotype is associated with phenotypic variability of body mass index (2012) (407)
Loss-of-function mutations in SLC30A8 protect against type 2 diabetes (2014) (405)
Genetics of Human Cardiovascular Disease (2012) (403)
Genetics of coronary artery disease: discovery, biology and clinical translation (2017) (397)
A structural variation reference for medical and population genetics (2020) (394)
A structural variation reference for medical and population genetics (2020) (394)
Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood (2019) (391)
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function (2016) (388)
Genetics of Blood Lipids Among ~300,000 Multi-Ethnic Participants of the Million Veteran Program (2018) (387)
Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure (2009) (370)
Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits (2013) (365)
Small Dense Low-Density Lipoprotein-Cholesterol Concentrations Predict Risk for Coronary Heart Disease: The Atherosclerosis Risk in Communities (ARIC) Study (2014) (355)
Genetic fine-mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci (2015) (349)
Distribution and Medical Impact of Loss-of-Function Variants in the Finnish Founder Population (2014) (348)
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals (2016) (347)
Forty-Three Loci Associated with Plasma Lipoprotein Size, Concentration, and Cholesterol Content in Genome-Wide Analysis (2009) (345)
Novel Associations of Multiple Genetic Loci With Plasma Levels of Factor VII, Factor VIII, and von Willebrand Factor: The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium (2010) (344)
Polygenic Risk Score Identifies Subgroup With Higher Burden of Atherosclerosis and Greater Relative Benefit From Statin Therapy in the Primary Prevention Setting (2017) (338)
A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study (2007) (331)
Genome-Wide Association Study of Coronary Heart Disease and Its Risk Factors in 8,090 African Americans: The NHLBI CARe Project (2011) (325)
Increased Small Low-Density Lipoprotein Particle Number: A Prominent Feature of the Metabolic Syndrome in the Framingham Heart Study (2005) (312)
A Genetic Variant Associated with Five Vascular Diseases Is a Distal Regulator of Endothelin-1 Gene Expression (2017) (308)
Shared Genetic Susceptibility to Ischemic Stroke and Coronary Artery Disease: A Genome-Wide Analysis of Common Variants (2014) (303)
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes (2017) (294)
Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks. (2014) (292)
Inactivating mutations in NPC1L1 and protection from coronary heart disease. (2014) (289)
A brief history of human disease genetics (2020) (288)
Genome-Wide Association Study for Coronary Artery Calcification With Follow-Up in Myocardial Infarction (2011) (286)
Vitamin K and vitamin D status: associations with inflammatory markers in the Framingham Offspring Study. (2007) (285)
Genome-Wide Association Study of Blood Pressure Extremes Identifies Variant near UMOD Associated with Hypertension (2010) (285)
Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease (2012) (283)
ANGPTL3 Deficiency and Protection Against Coronary Artery Disease. (2017) (278)
Common Missense Variant in the Glucokinase Regulatory Protein Gene Is Associated With Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations (2008) (272)
Genetic Association of Waist-to-Hip Ratio With Cardiometabolic Traits, Type 2 Diabetes, and Coronary Heart Disease (2017) (266)
Best Practices and Joint Calling of the HumanExome BeadChip: The CHARGE Consortium (2013) (250)
In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates (2021) (247)
Inflammatory biomarkers are associated with total brain volume (2007) (246)
Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity (2017) (244)
Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation (2017) (243)
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. (2012) (238)
Contribution of Clinical Correlates and 13 C-Reactive Protein Gene Polymorphisms to Interindividual Variability in Serum C-Reactive Protein Level (2006) (235)
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension (2016) (234)
Dysfunctional nitric oxide signalling increases risk of myocardial infarction (2013) (234)
CCL2 Polymorphisms Are Associated With Serum Monocyte Chemoattractant Protein-1 Levels and Myocardial Infarction in the Framingham Heart Study (2005) (231)
Genetic determinants of plasma triglycerides (2011) (229)
Large-Scale Gene-Centric Analysis Identifies Novel Variants for Coronary Artery Disease (2011) (228)
The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports (2007) (227)
Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms (2017) (224)
Genetically determined height and coronary artery disease. (2015) (220)
Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis (2015) (214)
Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque (2011) (214)
Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci (2016) (214)
Risk prediction by genetic risk scores for coronary heart disease is independent of self-reported family history (2015) (210)
Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism. (2012) (209)
Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease (2017) (204)
Design of the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Study: A Genome-Wide Association Meta-analysis Involving More Than 22 000 Cases and 60 000 Controls (2010) (203)
Genetic evidence of assortative mating in humans (2017) (199)
Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol. (2014) (197)
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure underpinning obesity (2017) (193)
Assessment of 2q23.1 microdeletion syndrome implicates MBD5 as a single causal locus of intellectual disability, epilepsy, and autism spectrum disorder. (2011) (190)
Integrative Genomics Reveals Novel Molecular Pathways and Gene Networks for Coronary Artery Disease (2014) (187)
Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans. (2009) (186)
Association of low-density lipoprotein cholesterol-related genetic variants with aortic valve calcium and incident aortic stenosis. (2014) (186)
Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions (2020) (186)
Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study (2011) (185)
Inherited Causes of Clonal Hematopoiesis in 97,691 TOPMed Whole Genomes (2020) (184)
Clinical and Genetic Correlates of Aldosterone-to-Renin Ratio and Relations to Blood Pressure in a Community Sample (2007) (183)
Genetic Interleukin 6 Signaling Deficiency Attenuates Cardiovascular Risk in Clonal Hematopoiesis (2019) (183)
Meta-Analysis of Gene Level Tests for Rare Variant Association (2013) (183)
Genetics and causality of triglyceride-rich lipoproteins in atherosclerotic cardiovascular disease. (2014) (183)
Biological and clinical insights from genetics of insomnia symptoms (2018) (175)
Prospective functional classification of all possible missense variants in PPARG (2016) (167)
Genetic Analysis in UK Biobank Links Insulin Resistance and Transendothelial Migration Pathways to Coronary Artery Disease (2017) (166)
A PCSK9 missense variant associated with a reduced risk of early-onset myocardial infarction. (2008) (165)
A comparison of cardiac troponin T and creatine kinase-MB for patient evaluation after cardiac surgery. (2002) (164)
Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels. (2016) (164)
Polymorphisms Associated With Cholesterol and Risk of Cardiovascular Events (2008) (163)
Association of sickle cell trait with chronic kidney disease and albuminuria in African Americans. (2014) (163)
Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease. (2013) (160)
Whole-Genome Sequencing to Characterize Monogenic and Polygenic Contributions in Patients Hospitalized With Early-Onset Myocardial Infarction (2019) (160)
Exome sequencing and complex disease: practical aspects of rare variant association studies (2012) (155)
Clinical and Genetic Association of Serum Paraoxonase and Arylesterase Activities With Cardiovascular Risk (2012) (154)
Cardiovascular Event Prediction and Risk Reclassification by Coronary, Aortic, and Valvular Calcification in the Framingham Heart Study (2016) (151)
Ion Mobility Analysis of Lipoprotein Subfractions Identifies Three Independent Axes of Cardiovascular Risk (2009) (150)
Increased Burden of Cardiovascular Disease in Carriers of APOL1 Genetic Variants (2014) (149)
Multiple rare alleles at LDLR and APOA5 confer risk for early-onset myocardial infarction (2014) (147)
Candidate Gene Association Resource (CARe): Design, Methods, and Proof of Concept (2010) (143)
Single Cell Analysis of the Normal Mouse Aorta Reveals Functionally Distinct Endothelial Cell Populations. (2019) (142)
A Genome-Wide Association Study Identifies LIPA as a Susceptibility Gene for Coronary Artery Disease (2011) (141)
Relation of multiple inflammatory biomarkers to incident atrial fibrillation. (2009) (139)
Mutations of CASK cause an X-linked brain malformation phenotype with microcephaly and hypoplasia of the brainstem and cerebellum (2008) (138)
Novel genetic markers associate with atrial fibrillation risk in Europeans and Japanese. (2014) (137)
Biomarkers of the Osteoprotegerin Pathway: Clinical Correlates, Subclinical Disease, Incident Cardiovascular Disease, and Mortality (2010) (137)
Association of Rare and Common Variation in the Lipoprotein Lipase Gene With Coronary Artery Disease (2017) (135)
Trib1 is a lipid- and myocardial infarction-associated gene that regulates hepatic lipogenesis and VLDL production in mice. (2010) (135)
Causal Assessment of Serum Urate Levels in Cardiometabolic Diseases Through a Mendelian Randomization Study. (2016) (134)
Association Study of Common Genetic Variants and HIV-1 Acquisition in 6,300 Infected Cases and 7,200 Controls (2013) (133)
Multiethnic Meta-Analysis of Genome-Wide Association Studies in >100 000 Subjects Identifies 23 Fibrinogen-Associated Loci but No Strong Evidence of a Causal Association Between Circulating Fibrinogen and Cardiovascular Disease (2013) (133)
The power of genetic diversity in genome-wide association studies of lipids (2021) (129)
Assessing the phenotypic effects in the general population of rare variants in genes for a dominant Mendelian form of diabetes (2013) (128)
Power in the phenotypic extremes: a simulation study of power in discovery and replication of rare variants (2011) (128)
Genetics of Common, Complex Coronary Artery Disease (2019) (128)
Surprises From Genetic Analyses of Lipid Risk Factors for Atherosclerosis. (2016) (127)
Genome-wide Association Study of Peripheral Artery Disease in the Million Veteran Program (2019) (125)
Deep-coverage whole genome sequences and blood lipids among 16,324 individuals (2017) (124)
Large, Diverse Population Cohorts of hiPSCs and Derived Hepatocyte-like Cells Reveal Functional Genetic Variation at Blood Lipid-Associated Loci. (2017) (121)
Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney (2017) (121)
Burden of rare sarcomere gene variants in the Framingham and Jackson Heart Study cohorts. (2012) (120)
Inflammation, kidney function and albuminuria in the Framingham Offspring cohort. (2011) (120)
Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores (2015) (116)
Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data. (2009) (115)
Genome-wide association with select biomarker traits in the Framingham Heart Study (2007) (114)
Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease. (2017) (112)
Cross-Sectional Relations of Multiple Biomarkers From Distinct Biological Pathways to Brachial Artery Endothelial Function (2006) (108)
Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy (2020) (107)
Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis (2015) (106)
Association Between Titin Loss-of-Function Variants and Early-Onset Atrial Fibrillation (2018) (106)
Genome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease (2019) (105)
Genetic Differences between the Determinants of Lipid Profile Phenotypes in African and European Americans: The Jackson Heart Study (2009) (105)
Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants contributing to lipid levels and coronary artery disease (2017) (103)
Description of a Large Family with Autosomal Dominant Hypercholesterolemia Associated with the APOE p.Leu167del Mutation (2013) (102)
Comparing strategies to fine-map the association of common SNPs at chromosome 9p21 with type 2 diabetes and myocardial infarction (2011) (101)
Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study (2007) (99)
Exome Sequencing and Directed Clinical Phenotyping Diagnose Cholesterol Ester Storage Disease Presenting as Autosomal Recessive Hypercholesterolemia (2013) (98)
Twelve–Single Nucleotide Polymorphism Genetic Risk Score Identifies Individuals at Increased Risk for Future Atrial Fibrillation and Stroke (2014) (97)
Associations of long-term and early adult atherosclerosis risk factors with aortic and mitral valve calcium. (2010) (95)
Loss of Function of GALNT2 Lowers High-Density Lipoproteins in Humans, Nonhuman Primates, and Rodents. (2016) (95)
Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation. (2012) (93)
Association of Novel Genetic Loci With Circulating Fibrinogen Levels: A Genome-Wide Association Study in 6 Population-Based Cohorts (2009) (93)
Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole genome sequencing studies at scale (2020) (93)
Phenotypic Refinement of Heart Failure in a National Biobank Facilitates Genetic Discovery (2019) (92)
A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease (2016) (92)
Cardiac troponin T elevation after coronary artery bypass grafting is associated with increased one-year mortality. (2004) (91)
Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes (2018) (91)
A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease (2019) (90)
Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies. (2010) (89)
An Increased Burden of Common and Rare Lipid-Associated Risk Alleles Contributes to the Phenotypic Spectrum of Hypertriglyceridemia (2011) (89)
Transcript expression-aware annotation improves rare variant interpretation (2020) (89)
Eight blood pressure loci identified by genome-wide association study of 34,433 people of European ancestry (2009) (88)
Lp(a) (Lipoprotein[a]) Concentrations and Incident Atherosclerotic Cardiovascular Disease (2020) (88)
Multiple Inflammatory Biomarkers in Relation to Cardiovascular Events and Mortality in the Community (2013) (87)
Evaluating drug targets through human loss-of-function genetic variation (2019) (86)
A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels (2017) (86)
Advances in genetics show the need for extending screening strategies for autosomal dominant hypercholesterolaemia. (2012) (85)
Mapping and characterization of structural variation in 17,795 human genomes (2020) (84)
Comprehensive Survey of Common Genetic Variation at the Plasminogen Activator Inhibitor-1 Locus and Relations to Circulating Plasminogen Activator Inhibitor-1 Levels (2005) (81)
Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals. (2016) (81)
Excess of Rare Variants in Non–Genome-Wide Association Study Candidate Genes in Patients With Hypertriglyceridemia (2012) (81)
Myocardial Infarction–Associated SNP at 6p24 Interferes With MEF2 Binding and Associates With PHACTR1 Expression Levels in Human Coronary Arteries (2015) (80)
An open resource of structural variation for medical and population genetics (2019) (80)
Ultra-rare disruptive and damaging mutations influence educational attainment in the general population (2016) (79)
Common Genetic Variation in Five Thrombosis Genes and Relations to Plasma Hemostatic Protein Level and Cardiovascular Disease Risk (2006) (79)
Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study (2007) (79)
Genetic Association of Albuminuria with Cardiometabolic Disease and Blood Pressure. (2018) (79)
APOE p.Leu167del mutation in familial hypercholesterolemia. (2013) (78)
Causal Effect of Plasminogen Activator Inhibitor Type 1 on Coronary Heart Disease (2017) (78)
Influence of 9p21.3 genetic variants on clinical and angiographic outcomes in early-onset myocardial infarction. (2011) (78)
Characterising the loss-of-function impact of 5’ untranslated region variants in 15,708 individuals (2019) (78)
Genetic Risk Prediction of Atrial Fibrillation (2017) (77)
Quantifying the Impact of Rare and Ultra-rare Coding Variation across the Phenotypic Spectrum. (2018) (76)
Genetic Predisposition to Higher Blood Pressure Increases Coronary Artery Disease Risk (2013) (75)
Pericardial Fat Volume Correlates With Inflammatory Markers: The Framingham Heart Study (2010) (75)
Clinical and genetic correlates of serum aldosterone in the community: the Framingham Heart Study. (2005) (74)
A Novel APOB Mutation Identified by Exome Sequencing Cosegregates With Steatosis, Liver Cancer, and Hypocholesterolemia (2013) (74)
Genetic Analysis of Venous Thromboembolism in UK Biobank Identifies the ZFPM2 Locus and Implicates Obesity as a Causal Risk Factor (2017) (73)
Bayesian meta-analysis of genetic association studies with different sets of markers. (2007) (72)
DASH: a method for identical-by-descent haplotype mapping uncovers association with recent variation. (2011) (72)
Prevalence of ANGPTL3 and APOB Gene Mutations in Subjects With Combined Hypolipidemia (2012) (70)
Phenotypic Consequences of a Genetic Predisposition to Enhanced Nitric Oxide Signaling (2018) (70)
Role of angiopoietin-like 3 (ANGPTL3) in regulating plasma level of low-density lipoprotein cholesterol. (2018) (69)
Surface expression of a T cell receptor beta (TCR-beta) chain in the absence of TCR-alpha, -delta, and -gamma proteins (1991) (69)
The effect of LRRK2 loss-of-function variants in humans (2020) (69)
Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries (2017) (68)
Author Correction: Inherited causes of clonal haematopoiesis in 97,691 whole genomes (2021) (68)
Systems Genetics Analysis of Genome-Wide Association Study Reveals Novel Associations Between Key Biological Processes and Coronary Artery Disease (2015) (68)
Inherited myeloproliferative neoplasm risk impacts hematopoietic stem cells (2020) (67)
Association of Blood Lipids With Common DNA Sequence Variants at 19 Genetic Loci in the Multiethnic United States National Health and Nutrition Examination Survey III (2009) (66)
Limitations of Contemporary Guidelines for Managing Patients at High Genetic Risk of Coronary Artery Disease. (2020) (66)
An exome array study of the plasma metabolome (2016) (66)
Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits. (2016) (64)
Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease (2017) (64)
Genetic analysis for a shared biological basis between migraine and coronary artery disease (2015) (64)
Heritability of Atrial Fibrillation (2017) (60)
Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease (2018) (59)
CCL 2 Polymorphisms Are Associated With Serum Monocyte Chemoattractant Protein-1 Levels and Myocardial Infarction in the Framingham Heart Study (2005) (58)
Phenotypic extremes in rare variant study designs (2015) (58)
Clinical characteristics and plasma lipids in subjects with familial combined hypolipidemia: a pooled analysis[S] (2013) (56)
Aggregate penetrance of genomic variants for actionable disorders in European and African Americans (2016) (56)
Predicting Stroke Through Genetic Risk Functions: The CHARGE Risk Score Project (2014) (56)
The Human Cell Atlas White Paper (2018) (55)
The association of factor V Leiden with myocardial infarction is replicated in 1880 patients with premature disease (2010) (55)
Association of Rare Pathogenic DNA Variants for Familial Hypercholesterolemia, Hereditary Breast and Ovarian Cancer Syndrome, and Lynch Syndrome With Disease Risk in Adults According to Family History. (2020) (54)
Genetics of coronary artery disease. (2010) (53)
Assessment by cardiovascular magnetic resonance, electron beam computed tomography, and carotid ultrasonography of the distribution of subclinical atherosclerosis across Framingham risk strata. (2007) (53)
Effects of PCSK9 genetic variants on plasma LDL cholesterol levels and risk of premature myocardial infarction in the Italian population (2010) (52)
Recurring exon deletions in the haptoglobin (HP) gene associate with lower blood cholesterol levels (2016) (52)
hREC2, a RAD51-like gene, is disrupted by t(12;14) (q15;q24.1) in a uterine leiomyoma. (1999) (52)
Gene-Centric Meta-Analysis of Lipid Traits in African, East Asian and Hispanic Populations (2012) (51)
Strong association of the APOA5-1131T>C gene variant and early-onset acute myocardial infarction. (2011) (50)
Association of Habitual Alcohol Intake With Risk of Cardiovascular Disease (2022) (49)
Defining the spectrum of alleles that contribute to blood lipid concentrations in humans (2008) (49)
Low coverage whole genome sequencing enables accurate assessment of common variants and calculation of genome-wide polygenic scores (2019) (49)
Systematic Cell-Based Phenotyping of Missense Alleles Empowers Rare Variant Association Studies: A Case for LDLR and Myocardial Infarction (2015) (48)
Increased plasma osteoprotegerin concentrations are associated with indices of bone strength of the hip. (2008) (47)
Multi-Ethnic Analysis of Lipid-Associated Loci: The NHLBI CARe Project (2012) (47)
Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states. (2009) (47)
Clonal Hematopoiesis of Indeterminate Potential Reshapes Age-Related CVD: JACC Review Topic of the Week. (2019) (46)
Rare Protein-Truncating Variants in APOB, Lower Low-Density Lipoprotein Cholesterol, and Protection Against Coronary Heart Disease (2019) (46)
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (2019) (45)
Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants (2021) (45)
Association of genetic variation with cirrhosis: a multi-trait genome-wide association and gene-environment interaction study. (2020) (45)
Validation of a Genome-Wide Polygenic Score for Coronary Artery Disease in South Asians. (2020) (45)
Exome Sequencing in Suspected Monogenic Dyslipidemias (2015) (44)
Heritability, Linkage, and Genetic Associations of Exercise Treadmill Test Responses (2007) (43)
Vascular Stiffness and Genetic Variation at the Endothelial Nitric Oxide Synthase Locus: The Framingham Heart Study (2007) (43)
Genome-Wide Polygenic Score, Clinical Risk Factors, and Long-Term Trajectories of Coronary Artery Disease (2020) (43)
Developing medicines that mimic the natural successes of the human genome: lessons from NPC1L1, HMGCR, PCSK9, APOC3, and CETP. (2015) (42)
Association of APOC3 Loss-of-Function Mutations With Plasma Lipids and Subclinical Atherosclerosis: The Multi-Ethnic BioImage Study. (2015) (42)
Triglyceride response to an intensive lifestyle intervention is enhanced in carriers of the GCKR Pro446Leu polymorphism. (2011) (41)
New opportunities for identification and reduction of coronary risk: treatment of vulnerable patients, arteries, and plaques. (2006) (41)
Genetic Architecture of Abdominal Aortic Aneurysm in the Million Veteran Program (2020) (41)
Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions (2017) (41)
Association of exome sequences with plasma C-reactive protein levels in >9000 participants. (2015) (40)
Relations of long-term and contemporary lipid levels and lipid genetic risk scores with coronary artery calcium in the framingham heart study. (2012) (39)
Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis (2016) (39)
Diagnostic Yield of Sequencing Familial Hypercholesterolemia Genes in Patients with Severe Hypercholesterolemia. (2016) (39)
Genome-Wide Association Study for Circulating Tissue Plasminogen Activator Levels and Functional Follow-Up Implicates Endothelial STXBP5 and STX2 (2014) (39)
Clonal hematopoiesis associated with epigenetic aging and clinical outcomes (2021) (38)
Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study (2016) (37)
Mining the LIPG Allelic Spectrum Reveals the Contribution of Rare and Common Regulatory Variants to HDL Cholesterol (2011) (36)
On the interpretation of genetic association studies. (2004) (36)
Genetic variants in CETP increase risk of intracerebral hemorrhage (2016) (36)
Fine-Mapping in African Americans of 8 Recently Discovered Genetic Loci for Plasma Lipids: The Jackson Heart Study (2010) (36)
Large-scale genome-wide association study of coronary artery disease in genetically diverse populations (2022) (36)
Genome-wide polygenic score to identify a monogenic risk-equivalent for coronary disease (2017) (35)
Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms (2016) (35)
Kinetin and Gibberellic acid (GA3) act synergistically to produce high value polyunsaturated fatty acids in Nannochloropsis oceanica CASA CC201 (2018) (34)
Clonal Hematopoiesis: Somatic Mutations in Blood Cells and Atherosclerosis (2018) (32)
Leveraging human genetics to guide drug target discovery. (2017) (32)
Multiple Associated Variants Increase the Heritability Explained for Plasma Lipids and Coronary Artery Disease (2014) (32)
Is Coronary Atherosclerosis One Disease or Many? Setting Realistic Expectations for Precision Medicine. (2017) (31)
An eMERGE Clinical Center at Partners Personalized Medicine (2016) (30)
A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response (2021) (30)
The mouse QTL map helps interpret human genome-wide association studies for HDL cholesterol[S] (2011) (29)
Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes (2018) (29)
Genetics of lipid disorders (2010) (29)
Integrative analysis of the plasma proteome and polygenic risk of cardiometabolic diseases (2019) (29)
Recall by genotype and cascade screening for familial hypercholesterolemia in a population-based biobank from Estonia (2018) (29)
Aging syndrome genes and premature coronary artery disease (2005) (28)
Association of Genome-Wide Variation With Highly Sensitive Cardiac Troponin-T Levels in European Americans and Blacks: A Meta-Analysis From Atherosclerosis Risk in Communities and Cardiovascular Health Studies (2013) (28)
Evaluation of the Pooled Cohort Equations for Prediction of Cardiovascular Risk in a Contemporary Prospective Cohort. (2017) (27)
Common Genetic Variation at the Endothelial Nitric Oxide Synthase Locus and Relations to Brachial Artery Vasodilator Function in the Community (2005) (27)
Genetic variants primarily associated with type 2 diabetes are related to coronary artery disease risk. (2015) (26)
Non-parametric polygenic risk prediction using partitioned GWAS summary statistics (2018) (26)
Rare Genetic Variants Associated With Sudden Cardiac Death in Adults. (2019) (25)
No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis (2016) (25)
Whole exome sequencing combined with integrated variant annotation prediction identifies a causative myosin essential light chain variant in hypertrophic cardiomyopathy. (2016) (25)
Genome-wide association of early-onset myocardial infarction with common single nucleotide polymorphisms, common copy number variants, and rare copy number variants (2009) (25)
Genetically Elevated LDL Associates with Lower Risk of Intracerebral Hemorrhage (2020) (24)
PAI‐1 Gene 4G/5G Polymorphism and Risk of Type 2 Diabetes in a Population‐based Sample (2006) (24)
Glycated albumin and direct low density lipoprotein cholesterol levels in type 2 diabetes mellitus. (2009) (24)
Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (2018) (23)
Inherited Causes of Clonal Hematopoiesis of Indeterminate Potential in TOPMed Whole Genomes (2019) (23)
Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease (2020) (22)
Polygenic background modifies penetrance of monogenic variants conferring risk for coronary artery disease, breast cancer, or colorectal cancer (2019) (22)
Genetic invalidation of Lp-PLA2 as a therapeutic target: Large-scale study of five functional Lp-PLA2-lowering alleles (2016) (22)
Inherited causes of clonal haematopoiesis in 97,691 whole genomes (2020) (21)
Will cholesteryl ester transfer protein inhibition succeed primarily by lowering low-density lipoprotein cholesterol? Insights from human genetics and clinical trials. (2012) (21)
DNA Sequence Variation in ACVR1C Encoding the Activin Receptor-Like Kinase 7 Influences Body Fat Distribution and Protects Against Type 2 Diabetes (2018) (21)
Hypothesis-Based Analysis of Gene-Gene Interactions and Risk of Myocardial Infarction (2012) (21)
Genetic Variation at the Sulfonylurea Receptor, Type 2 Diabetes, and Coronary Heart Disease (2017) (21)
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (2017) (20)
Titin Truncating Variants in Adults Without Known Congestive Heart Failure. (2020) (20)
Lp(a) lipoprotein redux--from curious molecule to causal risk factor. (2009) (20)
Leveraging Human Genetics to Estimate Clinical Risk Reductions Achievable by Inhibiting Factor XI (2019) (20)
CLINICAL CHARACTERISTICS AND PLASMALIPIDS IN SUBJECTS WITH FAMILIALCOMBINED HYPOLIPIDEMIA:A POOLED ANALYSIS (2013) (19)
HapMap and Mapping Genes for Cardiovascular Disease (2008) (18)
Common and Rare Genetic Variation in CCR2, CCR5, or CX3CR1 and Risk of Atherosclerotic Coronary Heart Disease and Glucometabolic Traits (2016) (18)
Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits (2018) (17)
Polymorphisms in the endothelial nitric oxide synthase gene and bone density/ultrasound and geometry in humans. (2008) (17)
Genome-Wide Association Study for Circulating Tissue Plasminogen Activator Levels and Functional Follow-Up Implicates Endothelial STXBP 5 and STX 2 (2014) (17)
Association of common DNA sequence variants at 33 genetic loci with blood lipids in individuals of African ancestry from Jamaica (2010) (17)
Cardiovascular endocrinology: Is ANGPTL3 the next PCSK9? (2017) (16)
PCSK9 Inhibitors (2016) (16)
Transethnic Transferability of a Genome-wide Polygenic Score for Coronary Artery Disease. (2020) (16)
Association of APOL1 Risk Alleles with Cardiovascular Disease in African Americans in the Million Veteran Program. (2019) (15)
Off-pump coronary bypass grafting is associated with less myocardial injury than coronary bypass surgery with cardiopulmonary bypass. (2003) (14)
Gene-gene Interaction Analyses for Atrial Fibrillation (2016) (14)
Genetic analysis of over one million people identifies 535 novel loci for blood pressure (2017) (14)
Human knockouts in a cohort with a high rate of consanguinity (2015) (13)
An electronic cardiac rehabilitation referral system increases cardiac rehabilitation referrals (2017) (12)
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans (Nature Genetics (2008) 40, (189-197)) (2008) (12)
Targeted exonic sequencing of GWAS loci in the high extremes of the plasma lipids distribution. (2016) (12)
On the significance of linkage studies of complex traits. (2004) (12)
Heterozygous ABCG5 Gene Deficiency and Risk of Coronary Artery Disease (2020) (11)
A high-resolution HLA reference panel capturing global population diversity enables multi-ethnic fine-mapping in HIV host response (2020) (11)
Heterozygous ATP-binding Cassette Transporter G5 Gene Deficiency and Risk of Coronary Artery Disease. (2020) (11)
Functional characterization and substrate specificity analysis of Δ6-desaturase from marine microalga Isochrysis sp. (2018) (11)
Case records of the Massachusetts General Hospital. Case 14-2005. A 38-year-old man with fever and blurred vision. (2005) (11)
Candidate Gene Association Resource (CARe)Clinical Perspective (2010) (10)
Clinician Update: Direct Thrombin Inhibitors in Acute Coronary Syndromes (2003) (10)
Association of Exome Sequences With Cardiovascular Traits Among Blacks in the Jackson Heart Study (2016) (10)
Analysis of Gene-Gene Interactions among Common Variants in Candidate Cardiovascular Genes in Coronary Artery Disease (2015) (10)
ANGPTL 3 De fi ciency and Protection Against Coronary Artery Disease (2017) (10)
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (2018) (10)
Randomized prospective evaluation of genome sequencing versus standard-of-care as a first molecular diagnostic test (2020) (9)
A null mutation in ANGPTL8 does not associate with either plasma glucose or type 2 diabetes in humans (2016) (9)
Genome-wide association analysis identifies six new loci associated with blood low-density lipoprotein cholesterol , high-density lipoprotein cholesterol , or triglycerides in humans (2008) (9)
Rare coding variants in 35 genes associate with circulating lipid levels—A multi-ancestry analysis of 170,000 exomes (2021) (9)
Coronary Disease Association With ADAMTS7 Is Due to Protease Activity (2021) (9)
Correction: The Metabochip, a Custom Genotyping Array for Genetic Studies of Metabolic, Cardiovascular, and Anthropometric Traits (2013) (8)
The future of low-density lipoprotein cholesterol lowering therapy: An end to statin exceptionalism? (2016) (8)
Rare coding variants in 35 genes associate with circulating lipid levels – a multi-ancestry analysis of 170,000 exomes (2020) (8)
Erratum to: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits : (Nature Genetics, (2018), 50, 10, (1412-1425), 10.1038/s41588-018-0205-x) (2018) (8)
Genome-wide Polygenic Score and Cardiovascular Outcomes with Evacetrapib in Patients with High-risk Vascular Disease: A Nested Case-control Study. (2020) (8)
Efficacy and Safety of an Investigational Single-Course CRISPR Base-Editing Therapy Targeting PCSK9 in Nonhuman Primate and Mouse Models (2022) (8)
Identification and Functional Characterization of Two Novel Fatty Acid Genes from Marine Microalgae for Eicosapentaenoic Acid Production (2020) (7)
Response by Aragam et al to Letter Regarding Article, "Phenotypic Refinement of Heart Failure in a National Biobank Facilitates Genetic Discovery". (2019) (7)
Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices (2021) (7)
Frequency of silent myocardial ischemia following coronary stenting. (1999) (7)
P Lack of Association Between the Trp 719 Arg Polymorphism in Kinesin-Like Protein-6 and Coronary Artery Disease in 19 Case-Control Studies (2010) (7)
A large-scale multi-ethnic genome-wide association study of coronary artery disease (2021) (7)
An APOO Pseudogene on Chromosome 5q Is Associated With Low-Density Lipoprotein Cholesterol Levels (2018) (7)
Meta-Analysis of Gene Level Association Tests (2013) (6)
Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children with asthma. (2019) (6)
Plasma HDL cholesterol and risk of myocardial infarction – Authors' reply (2012) (6)
Genome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease (2019) (6)
Rare variants lowering the levels of coagulation factor X are protective against ischemic heart disease (2019) (6)
A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids (2021) (6)
HeterozygousABCG5Gene Deficiency and Risk of Coronary Artery Disease (2020) (5)
Heart disease: Putative medicines that mimic mutations (2017) (5)
Heterologous Production of Polyunsaturated Fatty Acids in E. coli Using Δ5-Desaturase Gene from Microalga Isochrysis Sp. (2020) (5)
Non-invasive imaging of plaque vulnerability: an important tool for the assessment of agents to stabilise atherosclerotic plaques (2002) (5)
Rare, Damaging DNA Variants in CORIN and Risk of Coronary Artery Disease (2021) (5)
Using the mouse model to confirm genes identified by genomewide association studies for the complex trait HDL cholesterol (2008) (5)
Antimicrobial activity of different tissues of snakehead fish Channa striatus (Bloch) (2012) (5)
EDEM3 Modulates Plasma Triglyceride Level through Its Regulation of LRP1 Expression (2019) (4)
Lipid nanoparticles incorporating a GalNAc ligand enable in vivo liver ANGPTL3 editing in wild-type and somatic LDLR knockout non-human primates (2021) (4)
Loss-of-function genomic variants with impact on liver-related blood traits highlight potential therapeutic targets for cardiovascular disease (2019) (4)
South Asian Patient Population Genetics Reveal Strong Founder Effects and High Rates of Homozygosity – New Resources for Precision Medicine (2020) (4)
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (2018) (4)
Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells (2020) (4)
Abstract 16565: Integration Of A Genome-wide Polygenic Score With ACC/AHA Pooled Cohorts Equation In Prediction Of Coronary Artery Disease Events In >285,000 Participants (2019) (4)
Supplementary Material 3 (2015) (3)
Supplementary Material 7 (2014) (3)
Multi-ethnic genome-wide association study for atrial fibrillation (2018) (3)
Correction: A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease (2021) (3)
Analysis of cardiac magnetic resonance imaging traits in 29,000 individuals reveals shared genetic basis with dilated cardiomyopathy (2020) (3)
Author Correction: The mutational constraint spectrum quantified from variation in 141,456 humans (2021) (3)
Algorithms for assessing cardiovascular risk in women. (2007) (3)
Author Correction: A structural variation reference for medical and population genetics (2021) (3)
Supplementary Material 5 (2014) (3)
Genetic predisposition to myeloproliferative neoplasms implicates hematopoietic stem cell biology (2019) (3)
Supplementary Material 6 (2014) (3)
Publisher Correction: Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries (2018) (3)
Genetic and clinical determinants of abdominal aortic diameter: genome-wide association studies, exome array data and Mendelian randomization study (2022) (2)
Analysis of gene-gene interactions among common variants in coronary artery disease (2014) (2)
Observational and Genetic Associations of Resting Heart Rate With Aortic Valve Calcium. (2018) (2)
Cholesterol gene polymorphisms and cardiovascular events - Reply (2008) (2)
Troponin T Elevation Following Cardiac Surgery Is Associated With Increased One-Year Mortality and Morbidity (2003) (2)
CLINICAL CHARACTERISTICS AND TREATMENT PATTERNS OF PATIENTS AT HIGH POLYGENIC RISK FOR CORONARY ARTERY DISEASE (2019) (2)
Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney (2017) (2)
Surface Expression of a T Cell Receptor Chain in the Absence of TCR-cr and "3' Proteins By Jennifer A. Punt,* Ralph T. Kubo, Takashi Saito, S (1991) (2)
Genetic Predisposition to Abdominal Obesity and Cardiometabolic Risk-Reply. (2017) (2)
Abstract 17380: Genetic Variation in PCSK9 and Protection From Peripheral Artery Disease (2017) (2)
Erratum: Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation (2017) (2)
Role of angiopoietin-like 3 (ANGPTL3) in regulating plasma level of low-density lipoproteins (2018) (2)
Heterozygous ATP-binding Cassette Transporter G5 Gene Deficiency and Risk of Coronary Artery Disease (2019) (2)
Genome-wide association study of peripheral artery disease in the Million Veteran Program (2019) (2)
Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus (2020) (1)
Transcript expression-aware annotation improves rare variant interpretation (2020) (1)
Genome-Wide Association Study of Over One Million Participants Identifies 49 Novel Loci Associated With Coronary Artery Disease (2019) (1)
RARE VARIANT ASSOCIATION STUDY FINDS NO LARGE-EFFECT, LOW-FREQUENCY VARIANTS FOR AORTIC AND MITRAL VALVE CALCIFICATION (2015) (1)
Enhanced Myocardial Repair with CardioChimeras (2013) (1)
Developing Genome-wide Polygenic Risk Scores for Coronary Artery Disease in South Asians (2020) (1)
Abstract 15044: Risk of Myocardial Infarction in Carriers of Familial Hypercholesterolemia Mutations is Modified by Common Variant Genetic Background or Adherence to a Healthy Lifestyle (2019) (1)
Abstract 4882: Factor V Leiden, But Not Prothrombin G20120A, Is Associated With Premature Myocardial Infarction (2008) (1)
GENETIC RISK, ADHERENCE TO A HEALTHY LIFESTYLE, AND RISK OF CORONARY ARTERY DISEASE (2017) (1)
A MULTI-LOCUS GENETIC RISK SCORE IS ASSOCIATED WITH INCIDENT ATRIAL FIBRILLATION AND ISCHEMIC STROKE AMONG 27,471 PARTICIPANTS FROM A PROSPECTIVE COHORT STUDY (2014) (1)
Abstract 056: Alcohol Increases Risk Of Cardiovascular Disease At All Levels Of Intake (2021) (1)
Abstract 17557: Genetic Variants Primarily Associated eith Type 2 Diabetes Also Affect Coronary Artery Disease Risk (2012) (1)
Publisher Correction: Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries (2018) (1)
JCL roundtable: Lessons from genetic variants altering lipoprotein metabolism. (2016) (1)
SEQUENTIAL IN VIVO CRISPR BASE EDITING OF THE PCSK9 AND ANGPTL3 GENES IN NON-HUMAN PRIMATES (2022) (1)
Supplementary Material 9 (2013) (1)
Endothelial ARHGEF26 is an angiogenic factor promoting VEGF signaling. (2021) (1)
Reply: Loss-of-Function Mutations to Estimate Pharmacological ANGPTL3 Inhibition. (2017) (1)
ANGPTL3 De ﬁ ciency and Protection Against Coronary Artery Disease (1)
Abstract 126: Genome Wide Association Study in the Million Veteran Program Identifies a Novel Role for Thrombosis in the Pathogenesis of Peripheral Artery Disease (2018) (1)
Supplementary Material 4 (2015) (1)
RARE PROTEIN-TRUNCATING VARIANTS IN APOB ASSOCIATE WITH LOWER LOW-DENSITY LIPOPROTEIN CHOLESTEROL, LOWER TRIGLYCERIDES, AND REDUCED RISK OF CORONARY HEART DISEASE (2019) (1)
Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries (2018) (1)
Abstract 35: Transcriptome-wide Association Study of Circulating Lipid Levels (2014) (1)
Neurocognitive trajectory and proteomic signature of inherited risk for Alzheimer’s disease (2022) (1)
Supplementary Material 15 (2013) (1)
Chapter 23 – Lipoprotein Disorders (2010) (1)
Abstract 14097: Cardiovascular Event Prediction and Risk Reclassification by Coronary, Aortic, and Valvular Calcification in the Framingham Heart Study (2013) (1)
Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program (2021) (1)
Gene Sequencing Identifies Perturbation in Nitric Oxide Signaling as a Nonlipid Molecular Subtype of Coronary Artery Disease (2022) (1)
Discovery and Refinement Supplementary (2015) (1)
Prevalence and clinical importance of titin truncating variants in adults without known congestive heart failure (2019) (1)
Clonal Hematopoiesis with Somatic Mutations Is a Common, Age-Related Condition Associated with Adverse Outcomes (2014) (1)
Author Correction: Landscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes (2021) (1)
Author Correction: Characterising the loss-of-function impact of 5’ untranslated region variants in 15,708 individuals (2021) (0)
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (2019) (0)
Quantifying the impact of rare and ultra-rare coding variation across the phenotypic spectrum (2017) (0)
Deep-coverage whole genome sequences and blood lipids among 16,324 individuals (2018) (0)
Genetic and non-genetic factors affecting the expression of COVID-19-relevant genes in the large airway epithelium (2021) (0)
SNPs and coronary heart disease Reply (2011) (0)
Publisher Correction: Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries (2018) (0)
Evaluating drug targets through human loss-of-function genetic variation (2020) (0)
Abstract 14241: A Meta-Analysis of Genome Wide Association Studies Identifies Novel Loci for Aortic Valvular and Mitral Annular Calcium and Implicates LPA in the Development of Aortic Stenosis (2011) (0)
Errata (2011) (0)
SNPs and coronary heart disease – Authors' reply (2011) (0)
Reply: Familial Hypercholesterolemia: Independent Malignity and LDLR Variant Databases. (2017) (0)
Contents (2020) (0)
Abstract 75: Somatic Overexpression and Knockdown in Mice to Identify Causal Genes Underlying 26 Lipid-associated Loci (2013) (0)
Abstract P100: Heritability of Atrial Fibrillation (2017) (0)
Author Correction: Evaluating drug targets through human loss-of-function genetic variation (2021) (0)
CHAPTER 55 – Lipoprotein Disorders (2009) (0)
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (2018) (0)
GENETICALLY ELEVATED LOW-DENSITY LIPOPROTEIN CHOLESTEROL IS ASSOCIATED WITH AORTIC VALVE CALCIFICATION AND INCIDENT AORTIC STENOSIS: A MENDELIAN RANDOMIZATION STUDY (2014) (0)
Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits (2018) (0)
Interactomics Analyses of Wild-type and Mutant A1CF Reveal Diverged Functions in Regulating Cellular Lipid Metabolism. (2020) (0)
O2-06-03: Inflammatory biomarkers are associated with total brain volume: The Framingham Heart Study (2006) (0)
A brief history of human disease genetics (2020) (0)
Recall by genotype and cascade screening for familial hypercholesterolemia in a population-based biobank from Estonia (2018) (0)
Title: Biological and clinical insights from genetics of insomnia symptoms Short Title: Insights from genetics of insomnia symptoms (2018) (0)
Abstract 4053: Serum Osteoprotegerin Levels are Related to Vascular Risk Factors and Vascular Calcification in the Community: The Framingham Heart Study (2006) (0)
The Unforgettable Cornerstone (0)
Evidence for a shared genetic determination of Ischemic Stroke And Coronary Artery Disease - a genome-wide analysis (2013) (0)
Abstract 16492: A Study of 63,253 Cases and 126,820 Controls Identifies Multiple Novel Loci for Coronary Artery Disease and Detects Independent Signals in Many of the Established Ones (2011) (0)
Author Correction: Transcript expression-aware annotation improves rare variant interpretation (2021) (0)
Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy (2020) (0)
Abstract 012: Performance of Polygenic Risk Scores for Coronary Artery Disease in the Million Veteran Program (2019) (0)
2018 Curt Stern Award Address. (2019) (0)
Exome sequencing as a tool to discover genes for heart attack risk and blood lipids (2011) (0)
Abstract 148: Initial Results from Electronic Referrals for Cardiac Rehabilitation (2014) (0)
the Signiﬁcance of Linkage Studies of Complex (2004) (0)
3 Clinician Update: Direct Thrombin Inhibitors and Low Molecular Weight Heparins in Acute Coronary Syndromes (2005) (0)
Mendelian Randomization as a Promising Approach to Define Which Biomarkers are Causal for Myocardial Infarction (2013) (0)
Factor V Leiden Is Associated with Premature Myocardial Infarction. (2008) (0)
1937-P: ALK-7: A Validated Target for the Treatment of Obesity (2020) (0)
Human knockouts and phenotypic analysis 1 in a cohort with a high rate of consanguinity 2 3 (2016) (0)
Author Correction: A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response (2021) (0)
A structural variation reference for medical and population genetics (2020) (0)
Whole-exome sequencing in patients with familial hypercholesterolemia without functional mutation in candidate genes. (2019) (0)
Genetic Risk, Lifestyle, and Coronary Artery Disease. (2017) (0)
Abstract 15260: Function of G Protein-Coupled Receptor 146 in Regulation of Blood Lipid Levels (2016) (0)
Apoe P.Leu167Del Mutation in Familial Hypercholesterolemia (2013) (0)
A structural variation reference for medical and population genetics (2020) (0)
CORONARY COMPUTED TOMOGRAPHY ANGIOGRAPHY AND WHOLE GENOME SEQUENCING AS AN APPROACH TO DISCOVER THE GENETIC BASIS OF DISEASE IN A FAMILY PRONE TO MYOCARDIAL INFARCTION (2014) (0)
Characterising the loss-of-function impact of 5’ untranslated region variants in 15,708 individuals (2020) (0)
Follow-Up in Myocardial Infarction Genome-Wide Association Study for Coronary Artery Calcification With (2011) (0)
A loss-of-function mutation in scarb1 severely impairs sr-bi processing and activity in humans (2014) (0)
Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes (2018) (0)
Genetics of Cardiovascular Disease and Its Role in Risk Prediction (2011) (0)
Abstract 217: Long-Term Follow-Up of an Electronic System for Referral to Cardiac Rehabilitation Shows Increase in Referrals and Utilization (2016) (0)
Addendum: The mutational constraint spectrum quantified from variation in 141,456 humans (2021) (0)
Abstract 18767: Association of Protein-Coding Genetic Variants with Coronary Arterial Calcification in 21,000 Individuals of European and African Ancestries (2014) (0)
Abstract 14476: Glycosylation-Dependent Lipoprotein Binding of Low-Density Lipoprotein Receptor-Like Domain of Perlecan and Implications for Atherosclerosis (2012) (0)
Abstract 18535: Rare Variants Identified With Whole Exome Chip Genotyping Are Associated With Insulin Resistance and Glycemic Control (2013) (0)
Prediction and Risk Reclassi fi cation by Coronary , Aortic , and Valvular Calci fi cation in the Framingham Heart Study (2016) (0)
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes (2018) (0)
Abstract 154: Genetic Variants in CETP That Increase HDL Levels also Increase Risk of Intracerebral Hemorrhage (2017) (0)
Abstract 11169: Whole Exome Sequencing in Subjects With Mendelian Form of Primary Severe Hypertriglyceridemia (2016) (0)
Distribution of ancestry in each cohort. (2020) (0)
Clinical value of Non Invasive assessment of Endothelial function in the Management of Coronary Artery Disease. (2008) (0)
Abstract 19854: Whole Genome Sequences and Plasma Lipids in 2,255 Participants (2016) (0)
Association of MARC1 A165T with metabolic traits. (2020) (0)
Rare loss of function variants in candidate genes and risk of colorectal cancer (2018) (0)
Coronary artery disease-protective A43T variant in APOC3 alters circulating ApoC-III levels in vivo (2015) (0)
Abstract 15407: Humanity in a Dish: Investigating a Common Genetic Basis for Human Metabolic Disease With Induced Pluripotent Stem Cells (2016) (0)
The effect of LRRK2 loss-of-function variants in humans (2020) (0)
2. Chemokines and their Receptors as Therapeutic Targets (2012) (0)
PLASMA HISTAMINE AND RISK OF MYOCARDIAL INFARCTION – BIOMARKER AND GENOTYPE ASSOCIATION ANALYSES (2014) (0)
Polygenic Risk Score Identifies Patients at Increased Risk for Abdominal Aortic Aneurysm and May Benefit from Ultrasound Screening (2020) (0)
for Blood Pressure Genome-Wide Association Studies, (2018). Genetic association of albuminuria with cardiometabolic disease and blood pressure. Human Genetics (2018) (0)
Identification of a new mutation in the N-terminal region of the apolipoprotein B gene in familial hypercholesterolemia (2016) (0)
Lack of Association Between the Trp 719 Arg Polymorphism in Kinesin-Like Protein-6 and Coronary Artery Disease in 19 Case-Control (2017) (0)
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits (2018) (0)
Protein-6 and Coronary Artery Disease in 19 Case-Control Studies Lack of Association Between the Trp719Arg Polymorphism in Kinesin-Like (2012) (0)
Methods in Genetics and Clinical Interpretation HapMap and Mapping Genes for Cardiovascular Disease (2008) (0)
Abstract 116: A Targeted Sequencing Approach in Subjects with Extremely High HDL-C Identifies individuals with Potentially Causal Mutations in Both Alleles of 53 Genes (2013) (0)
Biological and clinical insights from genetics of insomnia symptoms (2019) (0)
PRECLINICAL DATA SUPPORTING POTENTIAL EFFICACY OF VERVE-201 - AN INVESTIGATIONAL CRISPR BASE EDITING MEDICINE TARGETING ANGPTL3 - IN PRIMARY HUMAN CELLS, MICE, AND NON-HUMAN PRIMATES (2023) (0)
Abstract 16514: Interpretation of Whole Genome Sequences for Risk of Early-Onset Myocardial Infarction (2017) (0)
Author Correction: Inherited causes of clonal haematopoiesis in 97,691 whole genomes (2021) (0)
Abstract 17262: Identification of a Rare Variant Near Neurexin 1 Associated with Coronary Artery Disease (2010) (0)
ION Mobility Analysis Of Lipoprotein Subfractions Suggests Three Independent Mechanisms Of Cardiovascular Risk (2009) (0)
Abstract 233: Genetic Evidence for Overlap in the Pathogenesis of Peripheral Artery Disease and Coronary Artery Disease (2017) (0)
Abstract 18321: Analysis of a Consanguineous Cohort to Identify and Characterize Human Knockouts (2015) (0)
Abstract 18064: Lipid Reduction Measurements in a Veteran Population - Implications for Genetic Modeling in the Million Veteran Program (2016) (0)
Chapter 45 – Lipoprotein Disorders (2013) (0)
Publisher Correction: Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries (2020) (0)
3 – Genetics of Coronary Atherosclerosis (2018) (0)
Abstract 024: Association of APOL1 Risk Alleles with Coronary Heart Disease in Million Veteran Program (2018) (0)
Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program (2018) (0)
Supplementary Material (nature09270-s1) (2012) (0)
Abstract 47: Genetically Elevated Low-Density Lipoprotein Cholesterol is Associated with Aortic Valve Calcification and Incident Aortic Stenosis (2014) (0)
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (2018) (0)
Will Cholesteryl Ester Transfer Protein Inhibition Succeed Primarily by Lowering Low-Density Lipoprotein Cholesterol? (2020) (0)
Abstract 11298: Absence of Rare Coding Sequence Variants of Large Effect in GWAS Loci for High-Density Lipoprotein Cholesterol (2013) (0)
Short title: Musunuru et al; Design of NHLBI CARe (2017) (0)
Abstract MP055: Early and Long-Term Average Lipid Levels, As Compared With Contemporary Lipid Levels, Are More Strongly Associated with Coronary Artery Calcium in the Framingham Heart Study (2012) (0)
Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease (2018) (0)
Mendelian Randomization Study of ACLY and Cardiovascular Disease. (2020) (0)
DNA Sequence Variants Related to Plasma Triglycerides or High-Density Lipoprotein Cholesterol and Risk of Myocardial Infarction (2009) (0)
603 COMBINING EXOME SEQUENCING WITH EXCLUSION LINKAGE ANALYSIS AS A TOOL TO UNRAVEL THE MOLECULAR BASIS OF A COMMON GENETIC DISEASE (2011) (0)
Autism Sequencing Consortium (ASC) iPSYCH-BROAD Consortium Broad Institute Center for Common Disease Genomics (Broad-CCDG) (2021) (0)
Abstract 126: Identification of an Individual With Extremely High HDL-C Who is Homozygous for a Loss-of-function Mutation in Scavenger Receptor BI (SR-BI) and Functional Characterization of the Mutation (2013) (0)
Child-Parent Familial Hypercholesterolemia Screening in Primary Care. (2017) (0)
Author Correction: A structural variation reference for medical and population genetics (2021) (0)
Abstract 2739: The Proprotein Convertase Subtilisin-kexin Type 9 (PCSK9) R46L Variant Is Associated With Reduced Serum Low-density Lipoprotein Cholesterol In The Italian Population (2007) (0)
Abstract 332: Coronary Artery Disease-Protective Variant A43T in APOC3 Alters Circulating ApoC-III Levels In vivo (2015) (0)
2002 – GENETIC PREDISPOSITION TO MYELOPROLIFERATIVE NEOPLASMS IMPLICATES HEMATOPOIETIC STEM CELL BIOLOGY (2020) (0)
Landscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes (2020) (0)
PREVALENCE OF FAMILIAL HYPERCHOLESTEROLEMIA AND LDL CHOLESTEROL REDUCTION AMONG YOUNG ADULTS WITH MYOCARDIAL INFARCTION (2018) (0)
Leading Edge Review GeneticsofCommon , ComplexCoronaryArteryDisease (2019) (0)
Abstract # 10083: From Genotype to Phenotype at a Novel Cholesterol and Myocardial Infarction Locus (2010) (0)
POST-MYOCARDIAL INFARCTION MORTALITY IS ASSOCIATED WITH A GENETIC RISK SCORE (2014) (0)
Abstract 291: Association of Single Nucleotide Polymorphisms in Inflammatory Candidate Genes with Circulating Inflammatory Biomarker Concentrations: The Framingham Heart Study (2007) (0)
Rare loss-of-function mutations in the APOC3 gene, plasma triglycerides, and risk for coronary heart disease (2014) (0)
Author Correction: A structural variation reference for medical and population genetics (2021) (0)
Abstract 18993: Genetic Variants Primarily Associated With Inflammatory Bowel Disease Do Not Associate With Coronary Artery Disease (2014) (0)
Clonal Hematopoiesis of Indeterminate Potential Reshapes Biology of Age-Related CVD: JACC Topic of the Week (2019) (0)
Abstract 14363: Genetics of Coronary Atherosclerotic Plaque Rupture and Myocardial Infarction (2010) (0)
COMMON OR RARE GENETIC VARIATION IN THE CHEMOKINE RECEPTORS CCR2, CCR5, AND CX3CR1 DOES NOT RELATE TO CORONARY HEART DISEASE OR MYOCARDIAL INFARCTION IN HUMANS (2016) (0)
Interpretation of genome wide association data for lipoprotein traits using systems biology approach (2010) (0)
Abstract 021: ARHGEF26 is a Novel Genetic Risk Factor for Vascular Inflammation and Coronary Artery Disease (2018) (0)
Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale (2020) (0)
Abstract 3910: Long-term Exposure to Traditional Atherosclerotic Risk Factors and Presence of Aortic Valve Calcification (2006) (0)
Low coverage whole genome sequencing enables accurate assessment of common variants and calculation of genome-wide polygenic scores (2019) (0)
Abstract 18832: Trans-ethnic Genome-wide Association Study of Peripheral Artery Disease in the VA Million Veteran Program (2017) (0)
The mutational constraint spectrum quantified from variation in 141,456 humans (2020) (0)

This paper list is powered by the following services:

What Schools Are Affiliated With Sekar Kathiresan?

Sekar Kathiresan is affiliated with the following schools:

Sekar Kathiresan's Academic­Influence.com Rankings

Sekar Kathiresan's Degrees

Why Is Sekar Kathiresan Influential?

Sekar Kathiresan's Published Works

Published Works

What Schools Are Affiliated With Sekar Kathiresan?

Sekar Kathiresan's AcademicInfluence.com Rankings