Sekar Kathiresan
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Sekar Kathiresanbiology Degrees
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Philosophy Biology
Sekar Kathiresan's Degrees
- Doctorate Medicine Harvard University
- PhD Genetics Harvard University
Why Is Sekar Kathiresan Influential?
(Suggest an Edit or Addition)Sekar Kathiresan's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Genetic studies of body mass index yield new insights for obesity biology (2015) (3549)
- Biological, Clinical, and Population Relevance of 95 Loci for Blood Lipids (2010) (3485)
- Age-related clonal hematopoiesis associated with adverse outcomes. (2014) (2967)
- Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels (2007) (2888)
- Discovery and Refinement of Loci Associated with Lipid Levels (2013) (2475)
- Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index (2010) (2011)
- Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study (2012) (2002)
- Hundreds of variants clustered in genomic loci and biological pathways affect human height (2010) (1961)
- Genetic Variants in Novel Pathways Influence Blood Pressure and Cardiovascular Disease Risk (2011) (1928)
- Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes (2012) (1839)
- Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (2018) (1716)
- A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease (2015) (1567)
- Large-scale association analysis identifies new risk loci for coronary artery disease (2012) (1507)
- Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans (2008) (1392)
- Common variants at 30 loci contribute to polygenic dyslipidemia (2009) (1380)
- Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease (2017) (1358)
- Genome-wide association study identifies eight loci associated with blood pressure (2009) (1225)
- Association analyses of 249,796 individuals reveal eighteen new loci associated with body mass index (2010) (1179)
- Genome-wide meta-analyses identify multiple loci associated with smoking behavior (2010) (1107)
- Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants (2009) (1100)
- From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus (2010) (1048)
- Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility (2014) (933)
- Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease (2011) (894)
- Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores. (2015) (858)
- Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease. (2016) (847)
- Visceral and Subcutaneous Adipose Tissue Volumes Are Cross-Sectionally Related to Markers of Inflammation and Oxidative Stress: The Framingham Heart Study (2007) (841)
- Loss-of-function mutations in APOC3, triglycerides, and coronary disease. (2014) (799)
- Common variants associated with plasma triglycerides and risk for coronary artery disease (2013) (767)
- Identification of seven loci affecting mean telomere length and their association with disease (2013) (761)
- Genetic associations with valvular calcification and aortic stenosis. (2013) (723)
- Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits (2018) (659)
- Exome sequencing, ANGPTL3 mutations, and familial combined hypolipidemia. (2010) (630)
- Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia. (2016) (630)
- Testing for an Unusual Distribution of Rare Variants (2011) (595)
- Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture (2013) (568)
- Searching for missing heritability: Designing rare variant association studies (2014) (564)
- Polymorphisms associated with cholesterol and risk of cardiovascular events. (2008) (561)
- HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials (2015) (559)
- A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium (2009) (551)
- Meta-analysis identifies six new susceptibility loci for atrial fibrillation (2012) (535)
- The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study (2015) (532)
- A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses (2010) (531)
- Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials (2015) (515)
- Rare and low-frequency coding variants alter human adult height (2016) (511)
- New susceptibility locus for coronary artery disease on chromosome 3q22.3 (2009) (510)
- The Metabochip, a Custom Genotyping Array for Genetic Studies of Metabolic, Cardiovascular, and Anthropometric Traits (2012) (506)
- Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies (2011) (490)
- Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia (2010) (455)
- Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease (2016) (434)
- Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk (2017) (428)
- Exome-wide association study of plasma lipids in >300,000 individuals (2017) (428)
- Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction (2014) (426)
- Multi-ethnic genome-wide association study for atrial fibrillation (2018) (425)
- Concept, Design and Implementation of a Cardiovascular Gene-Centric 50 K SNP Array for Large-Scale Genomic Association Studies (2008) (416)
- Mendelian Randomization. (2017) (413)
- Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis (2012) (411)
- FTO genotype is associated with phenotypic variability of body mass index (2012) (407)
- Loss-of-function mutations in SLC30A8 protect against type 2 diabetes (2014) (405)
- Genetics of Human Cardiovascular Disease (2012) (403)
- Genetics of coronary artery disease: discovery, biology and clinical translation (2017) (397)
- A structural variation reference for medical and population genetics (2020) (394)
- A structural variation reference for medical and population genetics (2020) (394)
- Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood (2019) (391)
- Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function (2016) (388)
- Genetics of Blood Lipids Among ~300,000 Multi-Ethnic Participants of the Million Veteran Program (2018) (387)
- Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure (2009) (370)
- Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits (2013) (365)
- Small Dense Low-Density Lipoprotein-Cholesterol Concentrations Predict Risk for Coronary Heart Disease: The Atherosclerosis Risk in Communities (ARIC) Study (2014) (355)
- Genetic fine-mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci (2015) (349)
- Distribution and Medical Impact of Loss-of-Function Variants in the Finnish Founder Population (2014) (348)
- The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals (2016) (347)
- Forty-Three Loci Associated with Plasma Lipoprotein Size, Concentration, and Cholesterol Content in Genome-Wide Analysis (2009) (345)
- Novel Associations of Multiple Genetic Loci With Plasma Levels of Factor VII, Factor VIII, and von Willebrand Factor: The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium (2010) (344)
- Polygenic Risk Score Identifies Subgroup With Higher Burden of Atherosclerosis and Greater Relative Benefit From Statin Therapy in the Primary Prevention Setting (2017) (338)
- A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study (2007) (331)
- Genome-Wide Association Study of Coronary Heart Disease and Its Risk Factors in 8,090 African Americans: The NHLBI CARe Project (2011) (325)
- Increased Small Low-Density Lipoprotein Particle Number: A Prominent Feature of the Metabolic Syndrome in the Framingham Heart Study (2005) (312)
- A Genetic Variant Associated with Five Vascular Diseases Is a Distal Regulator of Endothelin-1 Gene Expression (2017) (308)
- Shared Genetic Susceptibility to Ischemic Stroke and Coronary Artery Disease: A Genome-Wide Analysis of Common Variants (2014) (303)
- Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes (2017) (294)
- Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks. (2014) (292)
- Inactivating mutations in NPC1L1 and protection from coronary heart disease. (2014) (289)
- A brief history of human disease genetics (2020) (288)
- Genome-Wide Association Study for Coronary Artery Calcification With Follow-Up in Myocardial Infarction (2011) (286)
- Vitamin K and vitamin D status: associations with inflammatory markers in the Framingham Offspring Study. (2007) (285)
- Genome-Wide Association Study of Blood Pressure Extremes Identifies Variant near UMOD Associated with Hypertension (2010) (285)
- Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease (2012) (283)
- ANGPTL3 Deficiency and Protection Against Coronary Artery Disease. (2017) (278)
- Common Missense Variant in the Glucokinase Regulatory Protein Gene Is Associated With Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations (2008) (272)
- Genetic Association of Waist-to-Hip Ratio With Cardiometabolic Traits, Type 2 Diabetes, and Coronary Heart Disease (2017) (266)
- Best Practices and Joint Calling of the HumanExome BeadChip: The CHARGE Consortium (2013) (250)
- In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates (2021) (247)
- Inflammatory biomarkers are associated with total brain volume (2007) (246)
- Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity (2017) (244)
- Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation (2017) (243)
- Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. (2012) (238)
- Contribution of Clinical Correlates and 13 C-Reactive Protein Gene Polymorphisms to Interindividual Variability in Serum C-Reactive Protein Level (2006) (235)
- Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension (2016) (234)
- Dysfunctional nitric oxide signalling increases risk of myocardial infarction (2013) (234)
- CCL2 Polymorphisms Are Associated With Serum Monocyte Chemoattractant Protein-1 Levels and Myocardial Infarction in the Framingham Heart Study (2005) (231)
- Genetic determinants of plasma triglycerides (2011) (229)
- Large-Scale Gene-Centric Analysis Identifies Novel Variants for Coronary Artery Disease (2011) (228)
- The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports (2007) (227)
- Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms (2017) (224)
- Genetically determined height and coronary artery disease. (2015) (220)
- Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis (2015) (214)
- Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque (2011) (214)
- Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci (2016) (214)
- Risk prediction by genetic risk scores for coronary heart disease is independent of self-reported family history (2015) (210)
- Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism. (2012) (209)
- Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease (2017) (204)
- Design of the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Study: A Genome-Wide Association Meta-analysis Involving More Than 22 000 Cases and 60 000 Controls (2010) (203)
- Genetic evidence of assortative mating in humans (2017) (199)
- Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol. (2014) (197)
- Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure underpinning obesity (2017) (193)
- Assessment of 2q23.1 microdeletion syndrome implicates MBD5 as a single causal locus of intellectual disability, epilepsy, and autism spectrum disorder. (2011) (190)
- Integrative Genomics Reveals Novel Molecular Pathways and Gene Networks for Coronary Artery Disease (2014) (187)
- Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans. (2009) (186)
- Association of low-density lipoprotein cholesterol-related genetic variants with aortic valve calcium and incident aortic stenosis. (2014) (186)
- Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions (2020) (186)
- Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study (2011) (185)
- Inherited Causes of Clonal Hematopoiesis in 97,691 TOPMed Whole Genomes (2020) (184)
- Clinical and Genetic Correlates of Aldosterone-to-Renin Ratio and Relations to Blood Pressure in a Community Sample (2007) (183)
- Genetic Interleukin 6 Signaling Deficiency Attenuates Cardiovascular Risk in Clonal Hematopoiesis (2019) (183)
- Meta-Analysis of Gene Level Tests for Rare Variant Association (2013) (183)
- Genetics and causality of triglyceride-rich lipoproteins in atherosclerotic cardiovascular disease. (2014) (183)
- Biological and clinical insights from genetics of insomnia symptoms (2018) (175)
- Prospective functional classification of all possible missense variants in PPARG (2016) (167)
- Genetic Analysis in UK Biobank Links Insulin Resistance and Transendothelial Migration Pathways to Coronary Artery Disease (2017) (166)
- A PCSK9 missense variant associated with a reduced risk of early-onset myocardial infarction. (2008) (165)
- A comparison of cardiac troponin T and creatine kinase-MB for patient evaluation after cardiac surgery. (2002) (164)
- Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels. (2016) (164)
- Polymorphisms Associated With Cholesterol and Risk of Cardiovascular Events (2008) (163)
- Association of sickle cell trait with chronic kidney disease and albuminuria in African Americans. (2014) (163)
- Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease. (2013) (160)
- Whole-Genome Sequencing to Characterize Monogenic and Polygenic Contributions in Patients Hospitalized With Early-Onset Myocardial Infarction (2019) (160)
- Exome sequencing and complex disease: practical aspects of rare variant association studies (2012) (155)
- Clinical and Genetic Association of Serum Paraoxonase and Arylesterase Activities With Cardiovascular Risk (2012) (154)
- Cardiovascular Event Prediction and Risk Reclassification by Coronary, Aortic, and Valvular Calcification in the Framingham Heart Study (2016) (151)
- Ion Mobility Analysis of Lipoprotein Subfractions Identifies Three Independent Axes of Cardiovascular Risk (2009) (150)
- Increased Burden of Cardiovascular Disease in Carriers of APOL1 Genetic Variants (2014) (149)
- Multiple rare alleles at LDLR and APOA5 confer risk for early-onset myocardial infarction (2014) (147)
- Candidate Gene Association Resource (CARe): Design, Methods, and Proof of Concept (2010) (143)
- Single Cell Analysis of the Normal Mouse Aorta Reveals Functionally Distinct Endothelial Cell Populations. (2019) (142)
- A Genome-Wide Association Study Identifies LIPA as a Susceptibility Gene for Coronary Artery Disease (2011) (141)
- Relation of multiple inflammatory biomarkers to incident atrial fibrillation. (2009) (139)
- Mutations of CASK cause an X-linked brain malformation phenotype with microcephaly and hypoplasia of the brainstem and cerebellum (2008) (138)
- Novel genetic markers associate with atrial fibrillation risk in Europeans and Japanese. (2014) (137)
- Biomarkers of the Osteoprotegerin Pathway: Clinical Correlates, Subclinical Disease, Incident Cardiovascular Disease, and Mortality (2010) (137)
- Association of Rare and Common Variation in the Lipoprotein Lipase Gene With Coronary Artery Disease (2017) (135)
- Trib1 is a lipid- and myocardial infarction-associated gene that regulates hepatic lipogenesis and VLDL production in mice. (2010) (135)
- Causal Assessment of Serum Urate Levels in Cardiometabolic Diseases Through a Mendelian Randomization Study. (2016) (134)
- Association Study of Common Genetic Variants and HIV-1 Acquisition in 6,300 Infected Cases and 7,200 Controls (2013) (133)
- Multiethnic Meta-Analysis of Genome-Wide Association Studies in >100 000 Subjects Identifies 23 Fibrinogen-Associated Loci but No Strong Evidence of a Causal Association Between Circulating Fibrinogen and Cardiovascular Disease (2013) (133)
- The power of genetic diversity in genome-wide association studies of lipids (2021) (129)
- Assessing the phenotypic effects in the general population of rare variants in genes for a dominant Mendelian form of diabetes (2013) (128)
- Power in the phenotypic extremes: a simulation study of power in discovery and replication of rare variants (2011) (128)
- Genetics of Common, Complex Coronary Artery Disease (2019) (128)
- Surprises From Genetic Analyses of Lipid Risk Factors for Atherosclerosis. (2016) (127)
- Genome-wide Association Study of Peripheral Artery Disease in the Million Veteran Program (2019) (125)
- Deep-coverage whole genome sequences and blood lipids among 16,324 individuals (2017) (124)
- Large, Diverse Population Cohorts of hiPSCs and Derived Hepatocyte-like Cells Reveal Functional Genetic Variation at Blood Lipid-Associated Loci. (2017) (121)
- Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney (2017) (121)
- Burden of rare sarcomere gene variants in the Framingham and Jackson Heart Study cohorts. (2012) (120)
- Inflammation, kidney function and albuminuria in the Framingham Offspring cohort. (2011) (120)
- Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores (2015) (116)
- Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data. (2009) (115)
- Genome-wide association with select biomarker traits in the Framingham Heart Study (2007) (114)
- Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease. (2017) (112)
- Cross-Sectional Relations of Multiple Biomarkers From Distinct Biological Pathways to Brachial Artery Endothelial Function (2006) (108)
- Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy (2020) (107)
- Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis (2015) (106)
- Association Between Titin Loss-of-Function Variants and Early-Onset Atrial Fibrillation (2018) (106)
- Genome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease (2019) (105)
- Genetic Differences between the Determinants of Lipid Profile Phenotypes in African and European Americans: The Jackson Heart Study (2009) (105)
- Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants contributing to lipid levels and coronary artery disease (2017) (103)
- Description of a Large Family with Autosomal Dominant Hypercholesterolemia Associated with the APOE p.Leu167del Mutation (2013) (102)
- Comparing strategies to fine-map the association of common SNPs at chromosome 9p21 with type 2 diabetes and myocardial infarction (2011) (101)
- Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study (2007) (99)
- Exome Sequencing and Directed Clinical Phenotyping Diagnose Cholesterol Ester Storage Disease Presenting as Autosomal Recessive Hypercholesterolemia (2013) (98)
- Twelve–Single Nucleotide Polymorphism Genetic Risk Score Identifies Individuals at Increased Risk for Future Atrial Fibrillation and Stroke (2014) (97)
- Associations of long-term and early adult atherosclerosis risk factors with aortic and mitral valve calcium. (2010) (95)
- Loss of Function of GALNT2 Lowers High-Density Lipoproteins in Humans, Nonhuman Primates, and Rodents. (2016) (95)
- Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation. (2012) (93)
- Association of Novel Genetic Loci With Circulating Fibrinogen Levels: A Genome-Wide Association Study in 6 Population-Based Cohorts (2009) (93)
- Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole genome sequencing studies at scale (2020) (93)
- Phenotypic Refinement of Heart Failure in a National Biobank Facilitates Genetic Discovery (2019) (92)
- A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease (2016) (92)
- Cardiac troponin T elevation after coronary artery bypass grafting is associated with increased one-year mortality. (2004) (91)
- Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes (2018) (91)
- A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease (2019) (90)
- Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies. (2010) (89)
- An Increased Burden of Common and Rare Lipid-Associated Risk Alleles Contributes to the Phenotypic Spectrum of Hypertriglyceridemia (2011) (89)
- Transcript expression-aware annotation improves rare variant interpretation (2020) (89)
- Eight blood pressure loci identified by genome-wide association study of 34,433 people of European ancestry (2009) (88)
- Lp(a) (Lipoprotein[a]) Concentrations and Incident Atherosclerotic Cardiovascular Disease (2020) (88)
- Multiple Inflammatory Biomarkers in Relation to Cardiovascular Events and Mortality in the Community (2013) (87)
- Evaluating drug targets through human loss-of-function genetic variation (2019) (86)
- A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels (2017) (86)
- Advances in genetics show the need for extending screening strategies for autosomal dominant hypercholesterolaemia. (2012) (85)
- Mapping and characterization of structural variation in 17,795 human genomes (2020) (84)
- Comprehensive Survey of Common Genetic Variation at the Plasminogen Activator Inhibitor-1 Locus and Relations to Circulating Plasminogen Activator Inhibitor-1 Levels (2005) (81)
- Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals. (2016) (81)
- Excess of Rare Variants in Non–Genome-Wide Association Study Candidate Genes in Patients With Hypertriglyceridemia (2012) (81)
- Myocardial Infarction–Associated SNP at 6p24 Interferes With MEF2 Binding and Associates With PHACTR1 Expression Levels in Human Coronary Arteries (2015) (80)
- An open resource of structural variation for medical and population genetics (2019) (80)
- Ultra-rare disruptive and damaging mutations influence educational attainment in the general population (2016) (79)
- Common Genetic Variation in Five Thrombosis Genes and Relations to Plasma Hemostatic Protein Level and Cardiovascular Disease Risk (2006) (79)
- Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study (2007) (79)
- Genetic Association of Albuminuria with Cardiometabolic Disease and Blood Pressure. (2018) (79)
- APOE p.Leu167del mutation in familial hypercholesterolemia. (2013) (78)
- Causal Effect of Plasminogen Activator Inhibitor Type 1 on Coronary Heart Disease (2017) (78)
- Influence of 9p21.3 genetic variants on clinical and angiographic outcomes in early-onset myocardial infarction. (2011) (78)
- Characterising the loss-of-function impact of 5’ untranslated region variants in 15,708 individuals (2019) (78)
- Genetic Risk Prediction of Atrial Fibrillation (2017) (77)
- Quantifying the Impact of Rare and Ultra-rare Coding Variation across the Phenotypic Spectrum. (2018) (76)
- Genetic Predisposition to Higher Blood Pressure Increases Coronary Artery Disease Risk (2013) (75)
- Pericardial Fat Volume Correlates With Inflammatory Markers: The Framingham Heart Study (2010) (75)
- Clinical and genetic correlates of serum aldosterone in the community: the Framingham Heart Study. (2005) (74)
- A Novel APOB Mutation Identified by Exome Sequencing Cosegregates With Steatosis, Liver Cancer, and Hypocholesterolemia (2013) (74)
- Genetic Analysis of Venous Thromboembolism in UK Biobank Identifies the ZFPM2 Locus and Implicates Obesity as a Causal Risk Factor (2017) (73)
- Bayesian meta-analysis of genetic association studies with different sets of markers. (2007) (72)
- DASH: a method for identical-by-descent haplotype mapping uncovers association with recent variation. (2011) (72)
- Prevalence of ANGPTL3 and APOB Gene Mutations in Subjects With Combined Hypolipidemia (2012) (70)
- Phenotypic Consequences of a Genetic Predisposition to Enhanced Nitric Oxide Signaling (2018) (70)
- Role of angiopoietin-like 3 (ANGPTL3) in regulating plasma level of low-density lipoprotein cholesterol. (2018) (69)
- Surface expression of a T cell receptor beta (TCR-beta) chain in the absence of TCR-alpha, -delta, and -gamma proteins (1991) (69)
- The effect of LRRK2 loss-of-function variants in humans (2020) (69)
- Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries (2017) (68)
- Author Correction: Inherited causes of clonal haematopoiesis in 97,691 whole genomes (2021) (68)
- Systems Genetics Analysis of Genome-Wide Association Study Reveals Novel Associations Between Key Biological Processes and Coronary Artery Disease (2015) (68)
- Inherited myeloproliferative neoplasm risk impacts hematopoietic stem cells (2020) (67)
- Association of Blood Lipids With Common DNA Sequence Variants at 19 Genetic Loci in the Multiethnic United States National Health and Nutrition Examination Survey III (2009) (66)
- Limitations of Contemporary Guidelines for Managing Patients at High Genetic Risk of Coronary Artery Disease. (2020) (66)
- An exome array study of the plasma metabolome (2016) (66)
- Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits. (2016) (64)
- Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease (2017) (64)
- Genetic analysis for a shared biological basis between migraine and coronary artery disease (2015) (64)
- Heritability of Atrial Fibrillation (2017) (60)
- Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease (2018) (59)
- CCL 2 Polymorphisms Are Associated With Serum Monocyte Chemoattractant Protein-1 Levels and Myocardial Infarction in the Framingham Heart Study (2005) (58)
- Phenotypic extremes in rare variant study designs (2015) (58)
- Clinical characteristics and plasma lipids in subjects with familial combined hypolipidemia: a pooled analysis[S] (2013) (56)
- Aggregate penetrance of genomic variants for actionable disorders in European and African Americans (2016) (56)
- Predicting Stroke Through Genetic Risk Functions: The CHARGE Risk Score Project (2014) (56)
- The Human Cell Atlas White Paper (2018) (55)
- The association of factor V Leiden with myocardial infarction is replicated in 1880 patients with premature disease (2010) (55)
- Association of Rare Pathogenic DNA Variants for Familial Hypercholesterolemia, Hereditary Breast and Ovarian Cancer Syndrome, and Lynch Syndrome With Disease Risk in Adults According to Family History. (2020) (54)
- Genetics of coronary artery disease. (2010) (53)
- Assessment by cardiovascular magnetic resonance, electron beam computed tomography, and carotid ultrasonography of the distribution of subclinical atherosclerosis across Framingham risk strata. (2007) (53)
- Effects of PCSK9 genetic variants on plasma LDL cholesterol levels and risk of premature myocardial infarction in the Italian population (2010) (52)
- Recurring exon deletions in the haptoglobin (HP) gene associate with lower blood cholesterol levels (2016) (52)
- hREC2, a RAD51-like gene, is disrupted by t(12;14) (q15;q24.1) in a uterine leiomyoma. (1999) (52)
- Gene-Centric Meta-Analysis of Lipid Traits in African, East Asian and Hispanic Populations (2012) (51)
- Strong association of the APOA5-1131T>C gene variant and early-onset acute myocardial infarction. (2011) (50)
- Association of Habitual Alcohol Intake With Risk of Cardiovascular Disease (2022) (49)
- Defining the spectrum of alleles that contribute to blood lipid concentrations in humans (2008) (49)
- Low coverage whole genome sequencing enables accurate assessment of common variants and calculation of genome-wide polygenic scores (2019) (49)
- Systematic Cell-Based Phenotyping of Missense Alleles Empowers Rare Variant Association Studies: A Case for LDLR and Myocardial Infarction (2015) (48)
- Increased plasma osteoprotegerin concentrations are associated with indices of bone strength of the hip. (2008) (47)
- Multi-Ethnic Analysis of Lipid-Associated Loci: The NHLBI CARe Project (2012) (47)
- Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states. (2009) (47)
- Clonal Hematopoiesis of Indeterminate Potential Reshapes Age-Related CVD: JACC Review Topic of the Week. (2019) (46)
- Rare Protein-Truncating Variants in APOB, Lower Low-Density Lipoprotein Cholesterol, and Protection Against Coronary Heart Disease (2019) (46)
- Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (2019) (45)
- Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants (2021) (45)
- Association of genetic variation with cirrhosis: a multi-trait genome-wide association and gene-environment interaction study. (2020) (45)
- Validation of a Genome-Wide Polygenic Score for Coronary Artery Disease in South Asians. (2020) (45)
- Exome Sequencing in Suspected Monogenic Dyslipidemias (2015) (44)
- Heritability, Linkage, and Genetic Associations of Exercise Treadmill Test Responses (2007) (43)
- Vascular Stiffness and Genetic Variation at the Endothelial Nitric Oxide Synthase Locus: The Framingham Heart Study (2007) (43)
- Genome-Wide Polygenic Score, Clinical Risk Factors, and Long-Term Trajectories of Coronary Artery Disease (2020) (43)
- Developing medicines that mimic the natural successes of the human genome: lessons from NPC1L1, HMGCR, PCSK9, APOC3, and CETP. (2015) (42)
- Association of APOC3 Loss-of-Function Mutations With Plasma Lipids and Subclinical Atherosclerosis: The Multi-Ethnic BioImage Study. (2015) (42)
- Triglyceride response to an intensive lifestyle intervention is enhanced in carriers of the GCKR Pro446Leu polymorphism. (2011) (41)
- New opportunities for identification and reduction of coronary risk: treatment of vulnerable patients, arteries, and plaques. (2006) (41)
- Genetic Architecture of Abdominal Aortic Aneurysm in the Million Veteran Program (2020) (41)
- Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions (2017) (41)
- Association of exome sequences with plasma C-reactive protein levels in >9000 participants. (2015) (40)
- Relations of long-term and contemporary lipid levels and lipid genetic risk scores with coronary artery calcium in the framingham heart study. (2012) (39)
- Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis (2016) (39)
- Diagnostic Yield of Sequencing Familial Hypercholesterolemia Genes in Patients with Severe Hypercholesterolemia. (2016) (39)
- Genome-Wide Association Study for Circulating Tissue Plasminogen Activator Levels and Functional Follow-Up Implicates Endothelial STXBP5 and STX2 (2014) (39)
- Clonal hematopoiesis associated with epigenetic aging and clinical outcomes (2021) (38)
- Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study (2016) (37)
- Mining the LIPG Allelic Spectrum Reveals the Contribution of Rare and Common Regulatory Variants to HDL Cholesterol (2011) (36)
- On the interpretation of genetic association studies. (2004) (36)
- Genetic variants in CETP increase risk of intracerebral hemorrhage (2016) (36)
- Fine-Mapping in African Americans of 8 Recently Discovered Genetic Loci for Plasma Lipids: The Jackson Heart Study (2010) (36)
- Large-scale genome-wide association study of coronary artery disease in genetically diverse populations (2022) (36)
- Genome-wide polygenic score to identify a monogenic risk-equivalent for coronary disease (2017) (35)
- Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms (2016) (35)
- Kinetin and Gibberellic acid (GA3) act synergistically to produce high value polyunsaturated fatty acids in Nannochloropsis oceanica CASA CC201 (2018) (34)
- Clonal Hematopoiesis: Somatic Mutations in Blood Cells and Atherosclerosis (2018) (32)
- Leveraging human genetics to guide drug target discovery. (2017) (32)
- Multiple Associated Variants Increase the Heritability Explained for Plasma Lipids and Coronary Artery Disease (2014) (32)
- Is Coronary Atherosclerosis One Disease or Many? Setting Realistic Expectations for Precision Medicine. (2017) (31)
- An eMERGE Clinical Center at Partners Personalized Medicine (2016) (30)
- A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response (2021) (30)
- The mouse QTL map helps interpret human genome-wide association studies for HDL cholesterol[S] (2011) (29)
- Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes (2018) (29)
- Genetics of lipid disorders (2010) (29)
- Integrative analysis of the plasma proteome and polygenic risk of cardiometabolic diseases (2019) (29)
- Recall by genotype and cascade screening for familial hypercholesterolemia in a population-based biobank from Estonia (2018) (29)
- Aging syndrome genes and premature coronary artery disease (2005) (28)
- Association of Genome-Wide Variation With Highly Sensitive Cardiac Troponin-T Levels in European Americans and Blacks: A Meta-Analysis From Atherosclerosis Risk in Communities and Cardiovascular Health Studies (2013) (28)
- Evaluation of the Pooled Cohort Equations for Prediction of Cardiovascular Risk in a Contemporary Prospective Cohort. (2017) (27)
- Common Genetic Variation at the Endothelial Nitric Oxide Synthase Locus and Relations to Brachial Artery Vasodilator Function in the Community (2005) (27)
- Genetic variants primarily associated with type 2 diabetes are related to coronary artery disease risk. (2015) (26)
- Non-parametric polygenic risk prediction using partitioned GWAS summary statistics (2018) (26)
- Rare Genetic Variants Associated With Sudden Cardiac Death in Adults. (2019) (25)
- No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis (2016) (25)
- Whole exome sequencing combined with integrated variant annotation prediction identifies a causative myosin essential light chain variant in hypertrophic cardiomyopathy. (2016) (25)
- Genome-wide association of early-onset myocardial infarction with common single nucleotide polymorphisms, common copy number variants, and rare copy number variants (2009) (25)
- Genetically Elevated LDL Associates with Lower Risk of Intracerebral Hemorrhage (2020) (24)
- PAI‐1 Gene 4G/5G Polymorphism and Risk of Type 2 Diabetes in a Population‐based Sample (2006) (24)
- Glycated albumin and direct low density lipoprotein cholesterol levels in type 2 diabetes mellitus. (2009) (24)
- Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (2018) (23)
- Inherited Causes of Clonal Hematopoiesis of Indeterminate Potential in TOPMed Whole Genomes (2019) (23)
- Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease (2020) (22)
- Polygenic background modifies penetrance of monogenic variants conferring risk for coronary artery disease, breast cancer, or colorectal cancer (2019) (22)
- Genetic invalidation of Lp-PLA2 as a therapeutic target: Large-scale study of five functional Lp-PLA2-lowering alleles (2016) (22)
- Inherited causes of clonal haematopoiesis in 97,691 whole genomes (2020) (21)
- Will cholesteryl ester transfer protein inhibition succeed primarily by lowering low-density lipoprotein cholesterol? Insights from human genetics and clinical trials. (2012) (21)
- DNA Sequence Variation in ACVR1C Encoding the Activin Receptor-Like Kinase 7 Influences Body Fat Distribution and Protects Against Type 2 Diabetes (2018) (21)
- Hypothesis-Based Analysis of Gene-Gene Interactions and Risk of Myocardial Infarction (2012) (21)
- Genetic Variation at the Sulfonylurea Receptor, Type 2 Diabetes, and Coronary Heart Disease (2017) (21)
- Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (2017) (20)
- Titin Truncating Variants in Adults Without Known Congestive Heart Failure. (2020) (20)
- Lp(a) lipoprotein redux--from curious molecule to causal risk factor. (2009) (20)
- Leveraging Human Genetics to Estimate Clinical Risk Reductions Achievable by Inhibiting Factor XI (2019) (20)
- CLINICAL CHARACTERISTICS AND PLASMALIPIDS IN SUBJECTS WITH FAMILIALCOMBINED HYPOLIPIDEMIA:A POOLED ANALYSIS (2013) (19)
- HapMap and Mapping Genes for Cardiovascular Disease (2008) (18)
- Common and Rare Genetic Variation in CCR2, CCR5, or CX3CR1 and Risk of Atherosclerotic Coronary Heart Disease and Glucometabolic Traits (2016) (18)
- Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits (2018) (17)
- Polymorphisms in the endothelial nitric oxide synthase gene and bone density/ultrasound and geometry in humans. (2008) (17)
- Genome-Wide Association Study for Circulating Tissue Plasminogen Activator Levels and Functional Follow-Up Implicates Endothelial STXBP 5 and STX 2 (2014) (17)
- Association of common DNA sequence variants at 33 genetic loci with blood lipids in individuals of African ancestry from Jamaica (2010) (17)
- Cardiovascular endocrinology: Is ANGPTL3 the next PCSK9? (2017) (16)
- PCSK9 Inhibitors (2016) (16)
- Transethnic Transferability of a Genome-wide Polygenic Score for Coronary Artery Disease. (2020) (16)
- Association of APOL1 Risk Alleles with Cardiovascular Disease in African Americans in the Million Veteran Program. (2019) (15)
- Off-pump coronary bypass grafting is associated with less myocardial injury than coronary bypass surgery with cardiopulmonary bypass. (2003) (14)
- Gene-gene Interaction Analyses for Atrial Fibrillation (2016) (14)
- Genetic analysis of over one million people identifies 535 novel loci for blood pressure (2017) (14)
- Human knockouts in a cohort with a high rate of consanguinity (2015) (13)
- An electronic cardiac rehabilitation referral system increases cardiac rehabilitation referrals (2017) (12)
- Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans (Nature Genetics (2008) 40, (189-197)) (2008) (12)
- Targeted exonic sequencing of GWAS loci in the high extremes of the plasma lipids distribution. (2016) (12)
- On the significance of linkage studies of complex traits. (2004) (12)
- Heterozygous ABCG5 Gene Deficiency and Risk of Coronary Artery Disease (2020) (11)
- A high-resolution HLA reference panel capturing global population diversity enables multi-ethnic fine-mapping in HIV host response (2020) (11)
- Heterozygous ATP-binding Cassette Transporter G5 Gene Deficiency and Risk of Coronary Artery Disease. (2020) (11)
- Functional characterization and substrate specificity analysis of Δ6-desaturase from marine microalga Isochrysis sp. (2018) (11)
- Case records of the Massachusetts General Hospital. Case 14-2005. A 38-year-old man with fever and blurred vision. (2005) (11)
- Candidate Gene Association Resource (CARe)Clinical Perspective (2010) (10)
- Clinician Update: Direct Thrombin Inhibitors in Acute Coronary Syndromes (2003) (10)
- Association of Exome Sequences With Cardiovascular Traits Among Blacks in the Jackson Heart Study (2016) (10)
- Analysis of Gene-Gene Interactions among Common Variants in Candidate Cardiovascular Genes in Coronary Artery Disease (2015) (10)
- ANGPTL 3 De fi ciency and Protection Against Coronary Artery Disease (2017) (10)
- Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (2018) (10)
- Randomized prospective evaluation of genome sequencing versus standard-of-care as a first molecular diagnostic test (2020) (9)
- A null mutation in ANGPTL8 does not associate with either plasma glucose or type 2 diabetes in humans (2016) (9)
- Genome-wide association analysis identifies six new loci associated with blood low-density lipoprotein cholesterol , high-density lipoprotein cholesterol , or triglycerides in humans (2008) (9)
- Rare coding variants in 35 genes associate with circulating lipid levels—A multi-ancestry analysis of 170,000 exomes (2021) (9)
- Coronary Disease Association With ADAMTS7 Is Due to Protease Activity (2021) (9)
- Correction: The Metabochip, a Custom Genotyping Array for Genetic Studies of Metabolic, Cardiovascular, and Anthropometric Traits (2013) (8)
- The future of low-density lipoprotein cholesterol lowering therapy: An end to statin exceptionalism? (2016) (8)
- Rare coding variants in 35 genes associate with circulating lipid levels – a multi-ancestry analysis of 170,000 exomes (2020) (8)
- Erratum to: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits : (Nature Genetics, (2018), 50, 10, (1412-1425), 10.1038/s41588-018-0205-x) (2018) (8)
- Genome-wide Polygenic Score and Cardiovascular Outcomes with Evacetrapib in Patients with High-risk Vascular Disease: A Nested Case-control Study. (2020) (8)
- Efficacy and Safety of an Investigational Single-Course CRISPR Base-Editing Therapy Targeting PCSK9 in Nonhuman Primate and Mouse Models (2022) (8)
- Identification and Functional Characterization of Two Novel Fatty Acid Genes from Marine Microalgae for Eicosapentaenoic Acid Production (2020) (7)
- Response by Aragam et al to Letter Regarding Article, "Phenotypic Refinement of Heart Failure in a National Biobank Facilitates Genetic Discovery". (2019) (7)
- Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices (2021) (7)
- Frequency of silent myocardial ischemia following coronary stenting. (1999) (7)
- P Lack of Association Between the Trp 719 Arg Polymorphism in Kinesin-Like Protein-6 and Coronary Artery Disease in 19 Case-Control Studies (2010) (7)
- A large-scale multi-ethnic genome-wide association study of coronary artery disease (2021) (7)
- An APOO Pseudogene on Chromosome 5q Is Associated With Low-Density Lipoprotein Cholesterol Levels (2018) (7)
- Meta-Analysis of Gene Level Association Tests (2013) (6)
- Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children with asthma. (2019) (6)
- Plasma HDL cholesterol and risk of myocardial infarction – Authors' reply (2012) (6)
- Genome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease (2019) (6)
- Rare variants lowering the levels of coagulation factor X are protective against ischemic heart disease (2019) (6)
- A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids (2021) (6)
- HeterozygousABCG5Gene Deficiency and Risk of Coronary Artery Disease (2020) (5)
- Heart disease: Putative medicines that mimic mutations (2017) (5)
- Heterologous Production of Polyunsaturated Fatty Acids in E. coli Using Δ5-Desaturase Gene from Microalga Isochrysis Sp. (2020) (5)
- Non-invasive imaging of plaque vulnerability: an important tool for the assessment of agents to stabilise atherosclerotic plaques (2002) (5)
- Rare, Damaging DNA Variants in CORIN and Risk of Coronary Artery Disease (2021) (5)
- Using the mouse model to confirm genes identified by genomewide association studies for the complex trait HDL cholesterol (2008) (5)
- Antimicrobial activity of different tissues of snakehead fish Channa striatus (Bloch) (2012) (5)
- EDEM3 Modulates Plasma Triglyceride Level through Its Regulation of LRP1 Expression (2019) (4)
- Lipid nanoparticles incorporating a GalNAc ligand enable in vivo liver ANGPTL3 editing in wild-type and somatic LDLR knockout non-human primates (2021) (4)
- Loss-of-function genomic variants with impact on liver-related blood traits highlight potential therapeutic targets for cardiovascular disease (2019) (4)
- South Asian Patient Population Genetics Reveal Strong Founder Effects and High Rates of Homozygosity – New Resources for Precision Medicine (2020) (4)
- Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (2018) (4)
- Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells (2020) (4)
- Abstract 16565: Integration Of A Genome-wide Polygenic Score With ACC/AHA Pooled Cohorts Equation In Prediction Of Coronary Artery Disease Events In >285,000 Participants (2019) (4)
- Supplementary Material 3 (2015) (3)
- Supplementary Material 7 (2014) (3)
- Multi-ethnic genome-wide association study for atrial fibrillation (2018) (3)
- Correction: A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease (2021) (3)
- Analysis of cardiac magnetic resonance imaging traits in 29,000 individuals reveals shared genetic basis with dilated cardiomyopathy (2020) (3)
- Author Correction: The mutational constraint spectrum quantified from variation in 141,456 humans (2021) (3)
- Algorithms for assessing cardiovascular risk in women. (2007) (3)
- Author Correction: A structural variation reference for medical and population genetics (2021) (3)
- Supplementary Material 5 (2014) (3)
- Genetic predisposition to myeloproliferative neoplasms implicates hematopoietic stem cell biology (2019) (3)
- Supplementary Material 6 (2014) (3)
- Publisher Correction: Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries (2018) (3)
- Genetic and clinical determinants of abdominal aortic diameter: genome-wide association studies, exome array data and Mendelian randomization study (2022) (2)
- Analysis of gene-gene interactions among common variants in coronary artery disease (2014) (2)
- Observational and Genetic Associations of Resting Heart Rate With Aortic Valve Calcium. (2018) (2)
- Cholesterol gene polymorphisms and cardiovascular events - Reply (2008) (2)
- Troponin T Elevation Following Cardiac Surgery Is Associated With Increased One-Year Mortality and Morbidity (2003) (2)
- CLINICAL CHARACTERISTICS AND TREATMENT PATTERNS OF PATIENTS AT HIGH POLYGENIC RISK FOR CORONARY ARTERY DISEASE (2019) (2)
- Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney (2017) (2)
- Surface Expression of a T Cell Receptor Chain in the Absence of TCR-cr and "3' Proteins By Jennifer A. Punt,* Ralph T. Kubo, Takashi Saito, S (1991) (2)
- Genetic Predisposition to Abdominal Obesity and Cardiometabolic Risk-Reply. (2017) (2)
- Abstract 17380: Genetic Variation in PCSK9 and Protection From Peripheral Artery Disease (2017) (2)
- Erratum: Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation (2017) (2)
- Role of angiopoietin-like 3 (ANGPTL3) in regulating plasma level of low-density lipoproteins (2018) (2)
- Heterozygous ATP-binding Cassette Transporter G5 Gene Deficiency and Risk of Coronary Artery Disease (2019) (2)
- Genome-wide association study of peripheral artery disease in the Million Veteran Program (2019) (2)
- Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus (2020) (1)
- Transcript expression-aware annotation improves rare variant interpretation (2020) (1)
- Genome-Wide Association Study of Over One Million Participants Identifies 49 Novel Loci Associated With Coronary Artery Disease (2019) (1)
- RARE VARIANT ASSOCIATION STUDY FINDS NO LARGE-EFFECT, LOW-FREQUENCY VARIANTS FOR AORTIC AND MITRAL VALVE CALCIFICATION (2015) (1)
- Enhanced Myocardial Repair with CardioChimeras (2013) (1)
- Developing Genome-wide Polygenic Risk Scores for Coronary Artery Disease in South Asians (2020) (1)
- Abstract 15044: Risk of Myocardial Infarction in Carriers of Familial Hypercholesterolemia Mutations is Modified by Common Variant Genetic Background or Adherence to a Healthy Lifestyle (2019) (1)
- Abstract 4882: Factor V Leiden, But Not Prothrombin G20120A, Is Associated With Premature Myocardial Infarction (2008) (1)
- GENETIC RISK, ADHERENCE TO A HEALTHY LIFESTYLE, AND RISK OF CORONARY ARTERY DISEASE (2017) (1)
- A MULTI-LOCUS GENETIC RISK SCORE IS ASSOCIATED WITH INCIDENT ATRIAL FIBRILLATION AND ISCHEMIC STROKE AMONG 27,471 PARTICIPANTS FROM A PROSPECTIVE COHORT STUDY (2014) (1)
- Abstract 056: Alcohol Increases Risk Of Cardiovascular Disease At All Levels Of Intake (2021) (1)
- Abstract 17557: Genetic Variants Primarily Associated eith Type 2 Diabetes Also Affect Coronary Artery Disease Risk (2012) (1)
- Publisher Correction: Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries (2018) (1)
- JCL roundtable: Lessons from genetic variants altering lipoprotein metabolism. (2016) (1)
- SEQUENTIAL IN VIVO CRISPR BASE EDITING OF THE PCSK9 AND ANGPTL3 GENES IN NON-HUMAN PRIMATES (2022) (1)
- Supplementary Material 9 (2013) (1)
- Endothelial ARHGEF26 is an angiogenic factor promoting VEGF signaling. (2021) (1)
- Reply: Loss-of-Function Mutations to Estimate Pharmacological ANGPTL3 Inhibition. (2017) (1)
- ANGPTL3 De fi ciency and Protection Against Coronary Artery Disease (1)
- Abstract 126: Genome Wide Association Study in the Million Veteran Program Identifies a Novel Role for Thrombosis in the Pathogenesis of Peripheral Artery Disease (2018) (1)
- Supplementary Material 4 (2015) (1)
- RARE PROTEIN-TRUNCATING VARIANTS IN APOB ASSOCIATE WITH LOWER LOW-DENSITY LIPOPROTEIN CHOLESTEROL, LOWER TRIGLYCERIDES, AND REDUCED RISK OF CORONARY HEART DISEASE (2019) (1)
- Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries (2018) (1)
- Abstract 35: Transcriptome-wide Association Study of Circulating Lipid Levels (2014) (1)
- Neurocognitive trajectory and proteomic signature of inherited risk for Alzheimer’s disease (2022) (1)
- Supplementary Material 15 (2013) (1)
- Chapter 23 – Lipoprotein Disorders (2010) (1)
- Abstract 14097: Cardiovascular Event Prediction and Risk Reclassification by Coronary, Aortic, and Valvular Calcification in the Framingham Heart Study (2013) (1)
- Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program (2021) (1)
- Gene Sequencing Identifies Perturbation in Nitric Oxide Signaling as a Nonlipid Molecular Subtype of Coronary Artery Disease (2022) (1)
- Discovery and Refinement Supplementary (2015) (1)
- Prevalence and clinical importance of titin truncating variants in adults without known congestive heart failure (2019) (1)
- Clonal Hematopoiesis with Somatic Mutations Is a Common, Age-Related Condition Associated with Adverse Outcomes (2014) (1)
- Author Correction: Landscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes (2021) (1)
- Author Correction: Characterising the loss-of-function impact of 5’ untranslated region variants in 15,708 individuals (2021) (0)
- Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (2019) (0)
- Quantifying the impact of rare and ultra-rare coding variation across the phenotypic spectrum (2017) (0)
- Deep-coverage whole genome sequences and blood lipids among 16,324 individuals (2018) (0)
- Genetic and non-genetic factors affecting the expression of COVID-19-relevant genes in the large airway epithelium (2021) (0)
- SNPs and coronary heart disease Reply (2011) (0)
- Publisher Correction: Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries (2018) (0)
- Evaluating drug targets through human loss-of-function genetic variation (2020) (0)
- Abstract 14241: A Meta-Analysis of Genome Wide Association Studies Identifies Novel Loci for Aortic Valvular and Mitral Annular Calcium and Implicates LPA in the Development of Aortic Stenosis (2011) (0)
- Errata (2011) (0)
- SNPs and coronary heart disease – Authors' reply (2011) (0)
- Reply: Familial Hypercholesterolemia: Independent Malignity and LDLR Variant Databases. (2017) (0)
- Contents (2020) (0)
- Abstract 75: Somatic Overexpression and Knockdown in Mice to Identify Causal Genes Underlying 26 Lipid-associated Loci (2013) (0)
- Abstract P100: Heritability of Atrial Fibrillation (2017) (0)
- Author Correction: Evaluating drug targets through human loss-of-function genetic variation (2021) (0)
- CHAPTER 55 – Lipoprotein Disorders (2009) (0)
- Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (2018) (0)
- GENETICALLY ELEVATED LOW-DENSITY LIPOPROTEIN CHOLESTEROL IS ASSOCIATED WITH AORTIC VALVE CALCIFICATION AND INCIDENT AORTIC STENOSIS: A MENDELIAN RANDOMIZATION STUDY (2014) (0)
- Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits (2018) (0)
- Interactomics Analyses of Wild-type and Mutant A1CF Reveal Diverged Functions in Regulating Cellular Lipid Metabolism. (2020) (0)
- O2-06-03: Inflammatory biomarkers are associated with total brain volume: The Framingham Heart Study (2006) (0)
- A brief history of human disease genetics (2020) (0)
- Recall by genotype and cascade screening for familial hypercholesterolemia in a population-based biobank from Estonia (2018) (0)
- Title: Biological and clinical insights from genetics of insomnia symptoms Short Title: Insights from genetics of insomnia symptoms (2018) (0)
- Abstract 4053: Serum Osteoprotegerin Levels are Related to Vascular Risk Factors and Vascular Calcification in the Community: The Framingham Heart Study (2006) (0)
- The Unforgettable Cornerstone (0)
- Evidence for a shared genetic determination of Ischemic Stroke And Coronary Artery Disease - a genome-wide analysis (2013) (0)
- Abstract 16492: A Study of 63,253 Cases and 126,820 Controls Identifies Multiple Novel Loci for Coronary Artery Disease and Detects Independent Signals in Many of the Established Ones (2011) (0)
- Author Correction: Transcript expression-aware annotation improves rare variant interpretation (2021) (0)
- Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy (2020) (0)
- Abstract 012: Performance of Polygenic Risk Scores for Coronary Artery Disease in the Million Veteran Program (2019) (0)
- 2018 Curt Stern Award Address. (2019) (0)
- Exome sequencing as a tool to discover genes for heart attack risk and blood lipids (2011) (0)
- Abstract 148: Initial Results from Electronic Referrals for Cardiac Rehabilitation (2014) (0)
- the Significance of Linkage Studies of Complex (2004) (0)
- 3 Clinician Update: Direct Thrombin Inhibitors and Low Molecular Weight Heparins in Acute Coronary Syndromes (2005) (0)
- Mendelian Randomization as a Promising Approach to Define Which Biomarkers are Causal for Myocardial Infarction (2013) (0)
- Factor V Leiden Is Associated with Premature Myocardial Infarction. (2008) (0)
- 1937-P: ALK-7: A Validated Target for the Treatment of Obesity (2020) (0)
- Human knockouts and phenotypic analysis 1 in a cohort with a high rate of consanguinity 2 3 (2016) (0)
- Author Correction: A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response (2021) (0)
- A structural variation reference for medical and population genetics (2020) (0)
- Whole-exome sequencing in patients with familial hypercholesterolemia without functional mutation in candidate genes. (2019) (0)
- Genetic Risk, Lifestyle, and Coronary Artery Disease. (2017) (0)
- Abstract 15260: Function of G Protein-Coupled Receptor 146 in Regulation of Blood Lipid Levels (2016) (0)
- Apoe P.Leu167Del Mutation in Familial Hypercholesterolemia (2013) (0)
- A structural variation reference for medical and population genetics (2020) (0)
- CORONARY COMPUTED TOMOGRAPHY ANGIOGRAPHY AND WHOLE GENOME SEQUENCING AS AN APPROACH TO DISCOVER THE GENETIC BASIS OF DISEASE IN A FAMILY PRONE TO MYOCARDIAL INFARCTION (2014) (0)
- Characterising the loss-of-function impact of 5’ untranslated region variants in 15,708 individuals (2020) (0)
- Follow-Up in Myocardial Infarction Genome-Wide Association Study for Coronary Artery Calcification With (2011) (0)
- A loss-of-function mutation in scarb1 severely impairs sr-bi processing and activity in humans (2014) (0)
- Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes (2018) (0)
- Genetics of Cardiovascular Disease and Its Role in Risk Prediction (2011) (0)
- Abstract 217: Long-Term Follow-Up of an Electronic System for Referral to Cardiac Rehabilitation Shows Increase in Referrals and Utilization (2016) (0)
- Addendum: The mutational constraint spectrum quantified from variation in 141,456 humans (2021) (0)
- Abstract 18767: Association of Protein-Coding Genetic Variants with Coronary Arterial Calcification in 21,000 Individuals of European and African Ancestries (2014) (0)
- Abstract 14476: Glycosylation-Dependent Lipoprotein Binding of Low-Density Lipoprotein Receptor-Like Domain of Perlecan and Implications for Atherosclerosis (2012) (0)
- Abstract 18535: Rare Variants Identified With Whole Exome Chip Genotyping Are Associated With Insulin Resistance and Glycemic Control (2013) (0)
- Prediction and Risk Reclassi fi cation by Coronary , Aortic , and Valvular Calci fi cation in the Framingham Heart Study (2016) (0)
- Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes (2018) (0)
- Abstract 154: Genetic Variants in CETP That Increase HDL Levels also Increase Risk of Intracerebral Hemorrhage (2017) (0)
- Abstract 11169: Whole Exome Sequencing in Subjects With Mendelian Form of Primary Severe Hypertriglyceridemia (2016) (0)
- Distribution of ancestry in each cohort. (2020) (0)
- Clinical value of Non Invasive assessment of Endothelial function in the Management of Coronary Artery Disease. (2008) (0)
- Abstract 19854: Whole Genome Sequences and Plasma Lipids in 2,255 Participants (2016) (0)
- Association of MARC1 A165T with metabolic traits. (2020) (0)
- Rare loss of function variants in candidate genes and risk of colorectal cancer (2018) (0)
- Coronary artery disease-protective A43T variant in APOC3 alters circulating ApoC-III levels in vivo (2015) (0)
- Abstract 15407: Humanity in a Dish: Investigating a Common Genetic Basis for Human Metabolic Disease With Induced Pluripotent Stem Cells (2016) (0)
- The effect of LRRK2 loss-of-function variants in humans (2020) (0)
- 2. Chemokines and their Receptors as Therapeutic Targets (2012) (0)
- PLASMA HISTAMINE AND RISK OF MYOCARDIAL INFARCTION – BIOMARKER AND GENOTYPE ASSOCIATION ANALYSES (2014) (0)
- Polygenic Risk Score Identifies Patients at Increased Risk for Abdominal Aortic Aneurysm and May Benefit from Ultrasound Screening (2020) (0)
- for Blood Pressure Genome-Wide Association Studies, (2018). Genetic association of albuminuria with cardiometabolic disease and blood pressure. Human Genetics (2018) (0)
- Identification of a new mutation in the N-terminal region of the apolipoprotein B gene in familial hypercholesterolemia (2016) (0)
- Lack of Association Between the Trp 719 Arg Polymorphism in Kinesin-Like Protein-6 and Coronary Artery Disease in 19 Case-Control (2017) (0)
- Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits (2018) (0)
- Protein-6 and Coronary Artery Disease in 19 Case-Control Studies Lack of Association Between the Trp719Arg Polymorphism in Kinesin-Like (2012) (0)
- Methods in Genetics and Clinical Interpretation HapMap and Mapping Genes for Cardiovascular Disease (2008) (0)
- Abstract 116: A Targeted Sequencing Approach in Subjects with Extremely High HDL-C Identifies individuals with Potentially Causal Mutations in Both Alleles of 53 Genes (2013) (0)
- Biological and clinical insights from genetics of insomnia symptoms (2019) (0)
- PRECLINICAL DATA SUPPORTING POTENTIAL EFFICACY OF VERVE-201 - AN INVESTIGATIONAL CRISPR BASE EDITING MEDICINE TARGETING ANGPTL3 - IN PRIMARY HUMAN CELLS, MICE, AND NON-HUMAN PRIMATES (2023) (0)
- Abstract 16514: Interpretation of Whole Genome Sequences for Risk of Early-Onset Myocardial Infarction (2017) (0)
- Author Correction: Inherited causes of clonal haematopoiesis in 97,691 whole genomes (2021) (0)
- Abstract 17262: Identification of a Rare Variant Near Neurexin 1 Associated with Coronary Artery Disease (2010) (0)
- ION Mobility Analysis Of Lipoprotein Subfractions Suggests Three Independent Mechanisms Of Cardiovascular Risk (2009) (0)
- Abstract 233: Genetic Evidence for Overlap in the Pathogenesis of Peripheral Artery Disease and Coronary Artery Disease (2017) (0)
- Abstract 18321: Analysis of a Consanguineous Cohort to Identify and Characterize Human Knockouts (2015) (0)
- Abstract 18064: Lipid Reduction Measurements in a Veteran Population - Implications for Genetic Modeling in the Million Veteran Program (2016) (0)
- Chapter 45 – Lipoprotein Disorders (2013) (0)
- Publisher Correction: Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries (2020) (0)
- 3 – Genetics of Coronary Atherosclerosis (2018) (0)
- Abstract 024: Association of APOL1 Risk Alleles with Coronary Heart Disease in Million Veteran Program (2018) (0)
- Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program (2018) (0)
- Supplementary Material (nature09270-s1) (2012) (0)
- Abstract 47: Genetically Elevated Low-Density Lipoprotein Cholesterol is Associated with Aortic Valve Calcification and Incident Aortic Stenosis (2014) (0)
- Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (2018) (0)
- Will Cholesteryl Ester Transfer Protein Inhibition Succeed Primarily by Lowering Low-Density Lipoprotein Cholesterol? (2020) (0)
- Abstract 11298: Absence of Rare Coding Sequence Variants of Large Effect in GWAS Loci for High-Density Lipoprotein Cholesterol (2013) (0)
- Short title: Musunuru et al; Design of NHLBI CARe (2017) (0)
- Abstract MP055: Early and Long-Term Average Lipid Levels, As Compared With Contemporary Lipid Levels, Are More Strongly Associated with Coronary Artery Calcium in the Framingham Heart Study (2012) (0)
- Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease (2018) (0)
- Mendelian Randomization Study of ACLY and Cardiovascular Disease. (2020) (0)
- DNA Sequence Variants Related to Plasma Triglycerides or High-Density Lipoprotein Cholesterol and Risk of Myocardial Infarction (2009) (0)
- 603 COMBINING EXOME SEQUENCING WITH EXCLUSION LINKAGE ANALYSIS AS A TOOL TO UNRAVEL THE MOLECULAR BASIS OF A COMMON GENETIC DISEASE (2011) (0)
- Autism Sequencing Consortium (ASC) iPSYCH-BROAD Consortium Broad Institute Center for Common Disease Genomics (Broad-CCDG) (2021) (0)
- Abstract 126: Identification of an Individual With Extremely High HDL-C Who is Homozygous for a Loss-of-function Mutation in Scavenger Receptor BI (SR-BI) and Functional Characterization of the Mutation (2013) (0)
- Child-Parent Familial Hypercholesterolemia Screening in Primary Care. (2017) (0)
- Author Correction: A structural variation reference for medical and population genetics (2021) (0)
- Abstract 2739: The Proprotein Convertase Subtilisin-kexin Type 9 (PCSK9) R46L Variant Is Associated With Reduced Serum Low-density Lipoprotein Cholesterol In The Italian Population (2007) (0)
- Abstract 332: Coronary Artery Disease-Protective Variant A43T in APOC3 Alters Circulating ApoC-III Levels In vivo (2015) (0)
- 2002 – GENETIC PREDISPOSITION TO MYELOPROLIFERATIVE NEOPLASMS IMPLICATES HEMATOPOIETIC STEM CELL BIOLOGY (2020) (0)
- Landscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes (2020) (0)
- PREVALENCE OF FAMILIAL HYPERCHOLESTEROLEMIA AND LDL CHOLESTEROL REDUCTION AMONG YOUNG ADULTS WITH MYOCARDIAL INFARCTION (2018) (0)
- Leading Edge Review GeneticsofCommon , ComplexCoronaryArteryDisease (2019) (0)
- Abstract # 10083: From Genotype to Phenotype at a Novel Cholesterol and Myocardial Infarction Locus (2010) (0)
- POST-MYOCARDIAL INFARCTION MORTALITY IS ASSOCIATED WITH A GENETIC RISK SCORE (2014) (0)
- Abstract 291: Association of Single Nucleotide Polymorphisms in Inflammatory Candidate Genes with Circulating Inflammatory Biomarker Concentrations: The Framingham Heart Study (2007) (0)
- Rare loss-of-function mutations in the APOC3 gene, plasma triglycerides, and risk for coronary heart disease (2014) (0)
- Author Correction: A structural variation reference for medical and population genetics (2021) (0)
- Abstract 18993: Genetic Variants Primarily Associated With Inflammatory Bowel Disease Do Not Associate With Coronary Artery Disease (2014) (0)
- Clonal Hematopoiesis of Indeterminate Potential Reshapes Biology of Age-Related CVD: JACC Topic of the Week (2019) (0)
- Abstract 14363: Genetics of Coronary Atherosclerotic Plaque Rupture and Myocardial Infarction (2010) (0)
- COMMON OR RARE GENETIC VARIATION IN THE CHEMOKINE RECEPTORS CCR2, CCR5, AND CX3CR1 DOES NOT RELATE TO CORONARY HEART DISEASE OR MYOCARDIAL INFARCTION IN HUMANS (2016) (0)
- Interpretation of genome wide association data for lipoprotein traits using systems biology approach (2010) (0)
- Abstract 021: ARHGEF26 is a Novel Genetic Risk Factor for Vascular Inflammation and Coronary Artery Disease (2018) (0)
- Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale (2020) (0)
- Abstract 3910: Long-term Exposure to Traditional Atherosclerotic Risk Factors and Presence of Aortic Valve Calcification (2006) (0)
- Low coverage whole genome sequencing enables accurate assessment of common variants and calculation of genome-wide polygenic scores (2019) (0)
- Abstract 18832: Trans-ethnic Genome-wide Association Study of Peripheral Artery Disease in the VA Million Veteran Program (2017) (0)
- The mutational constraint spectrum quantified from variation in 141,456 humans (2020) (0)
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