Serena Nik-Zainal
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British-Malaysian clinician
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Why Is Serena Nik-Zainal Influential?
(Suggest an Edit or Addition)According to Wikipedia, Serena Nik-Zainal is a British-Malaysian clinician who is a consultant in clinical genetics and Cancer Research UK advanced clinician scientist at the University of Cambridge. She makes use of genomics for clinical applications. She was awarded the Crick Lecture by the Royal Society in 2021. Serena Nik-Zainal was also recognized as one of the 100 Influential Women in Oncology by OncoDaily.
Serena Nik-Zainal's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Signatures of mutational processes in human cancer (2013) (7589)
- Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development (2011) (2047)
- Mutational Processes Molding the Genomes of 21 Breast Cancers (2012) (1622)
- The landscape of cancer genes and mutational processes in breast cancer (2012) (1610)
- Landscape of somatic mutations in 560 breast cancer whole genome sequences (2016) (1574)
- The patterns and dynamics of genomic instability in metastatic pancreatic cancer (2010) (1271)
- The Life History of 21 Breast Cancers (2012) (1180)
- Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts. (2011) (1090)
- A small-cell lung cancer genome with complex signatures of tobacco exposure (2010) (1031)
- Deciphering Signatures of Mutational Processes Operative in Human Cancer (2013) (981)
- Heterogeneity of genomic evolution and mutational profiles in multiple myeloma (2014) (743)
- Clock-like mutational processes in human somatic cells (2015) (729)
- Mutational signatures associated with tobacco smoking in human cancer (2016) (722)
- Mechanisms underlying mutational signatures in human cancers (2014) (675)
- Subclonal diversification of primary breast cancer revealed by multiregion sequencing (2015) (656)
- HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures (2017) (644)
- Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone (2013) (605)
- Recurrent rearrangements of chromosome 1q21.1 and variable pediatric phenotypes. (2008) (578)
- Analysis of the Genetic Phylogeny of Multifocal Prostate Cancer Identifies Multiple Independent Clonal Expansions in Neoplastic and Morphologically Normal Prostate Tissue (2015) (399)
- Patterns of somatic structural variation in human cancer genomes (2020) (377)
- Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer (2014) (358)
- A Compendium of Mutational Signatures of Environmental Agents (2019) (329)
- DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis (2013) (312)
- RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia (2013) (301)
- Genome sequencing of normal cells reveals developmental lineages and mutational processes (2014) (297)
- Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer (2017) (291)
- Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes (2014) (289)
- Association of a germline copy number polymorphism of APOBEC3A and APOBEC3B with burden of putative APOBEC-dependent mutations in breast cancer (2014) (248)
- Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis (2019) (242)
- Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells (2018) (230)
- Whole exome sequencing of adenoid cystic carcinoma. (2013) (226)
- Mutational signatures of ionizing radiation in second malignancies (2016) (207)
- Somatic mutations reveal asymmetric cellular dynamics in the early human embryo (2017) (204)
- The topography of mutational processes in breast cancer genomes (2016) (198)
- Comprehensive molecular characterization of mitochondrial genomes in human cancers (2017) (197)
- The genomic landscape of metastatic breast cancer highlights changes in mutation and signature frequencies (2019) (179)
- Arterial tortuosity syndrome: clinical and molecular findings in 12 newly identified families (2008) (176)
- The Life History of 21 Breast Cancers (2015) (173)
- The genome as a record of environmental exposure (2015) (161)
- Frequent mutation of the major cartilage collagen gene COL2A1 in chondrosarcoma (2013) (160)
- ESMO recommendations on predictive biomarker testing for homologous recombination deficiency and PARP inhibitor benefit in ovarian cancer. (2020) (158)
- Whole-genome-sequencing of triple negative breast cancers in a population-based clinical study (2019) (148)
- A mutational signature in gastric cancer suggests therapeutic strategies (2015) (145)
- cgpCaVEManWrapper: Simple Execution of CaVEMan in Order to Detect Somatic Single Nucleotide Variants in NGS Data (2016) (145)
- Ductal carcinoma in situ: to treat or not to treat, that is the question (2019) (131)
- Estimation of rearrangement phylogeny for cancer genomes. (2012) (128)
- A practical guide for mutational signature analysis in hematological malignancies (2019) (122)
- Homologous recombination DNA repair deficiency and PARP inhibition activity in primary triple negative breast cancer (2020) (119)
- Validating the concept of mutational signatures with isogenic cell models (2018) (114)
- A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns (2020) (113)
- A whole-genome sequence and transcriptome perspective on HER2-positive breast cancers (2016) (110)
- High incidence of recurrent copy number variants in patients with isolated and syndromic Müllerian aplasia (2011) (108)
- A practical framework and online tool for mutational signature analyses show intertissue variation and driver dependencies (2020) (107)
- Mutational Signatures in Breast Cancer: The Problem at the DNA Level (2017) (101)
- cgpPindel: Identifying Somatically Acquired Insertion and Deletion Events from Paired End Sequencing (2015) (94)
- ascatNgs: Identifying Somatically Acquired Copy‐Number Alterations from Whole‐Genome Sequencing Data (2016) (91)
- Processed pseudogenes acquired somatically during cancer development (2014) (87)
- Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration (2016) (86)
- Mutational History of a Human Cell Lineage from Somatic to Induced Pluripotent Stem Cells (2016) (80)
- Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells (2015) (75)
- Uncovering the genomic heterogeneity of multifocal breast cancer (2015) (73)
- The Genomic and Immune Landscapes of Lethal Metastatic Breast Cancer (2019) (73)
- Noncanonical secondary structures arising from non-B DNA motifs are determinants of mutagenesis (2017) (73)
- The circular RNome of primary breast cancer (2019) (70)
- A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers (2017) (67)
- Whole-Genome Sequencing Reveals Breast Cancers with Mismatch Repair Deficiency. (2017) (67)
- Mutational signatures: emerging concepts, caveats and clinical applications (2021) (67)
- A small cell lung cancer genome reports complex tobacco exposure signatures (2009) (58)
- A systematic CRISPR screen defines mutational mechanisms underpinning signatures caused by replication errors and endogenous DNA damage (2021) (51)
- Substitution mutational signatures in whole-genome–sequenced cancers in the UK population (2022) (46)
- The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models (2013) (45)
- Sex differences in oncogenic mutational processes (2019) (41)
- Low rates of mutation in clinical grade human pluripotent stem cells under different culture conditions (2020) (40)
- Exclusion of the GNAS locus in PHP‐Ib patients with broad GNAS methylation changes: Evidence for an autosomal recessive form of PHP‐Ib? (2011) (37)
- Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation (2018) (37)
- Direct Transcriptional Consequences of Somatic Mutation in Breast Cancer (2016) (36)
- Comprehensive molecular comparison of BRCA1 hypermethylated and BRCA1 mutated triple negative breast cancers (2020) (35)
- APOBEC3A/B deletion polymorphism and cancer risk (2017) (33)
- Whole-genome sequencing reveals clinically relevant insights into the aetiology of familial breast cancers (2019) (32)
- Dramatic response of metastatic cutaneous angiosarcoma to an immune checkpoint inhibitor in a patient with xeroderma pigmentosum: whole-genome sequencing aids treatment decision in end-stage disease (2019) (29)
- Whole-genome sequencing reveals clinically relevant insights into the aetiology of familial breast cancers. (2019) (28)
- Mutational mechanisms of amplifications revealed by analysis of clustered rearrangements in breast cancers (2018) (25)
- Signatures of mutational processes in human cancer this access benefits you. Your matters (2013) (23)
- Mutational signatures: experimental design and analytical framework (2020) (22)
- Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples (2020) (22)
- Preclinical In Vivo Validation of the RAD51 Test for Identification of Homologous Recombination-Deficient Tumors and Patient Stratification. (2022) (21)
- Familial Adrenocortical Carcinoma in Association With Lynch Syndrome (2016) (21)
- Epigenetic modifiers DNMT3A and BCOR are recurrently mutated in CYLD cutaneous syndrome (2019) (21)
- Spectrum of mutational signatures in T-cell lymphoma reveals a key role for UV radiation in cutaneous T-cell lymphoma (2021) (18)
- VAGrENT: Variation Annotation Generator (2015) (16)
- Corrigendum: Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue (2015) (16)
- Short inverted repeats contribute to localized mutability in human somatic cells (2017) (16)
- Substantial somatic genomic variation and selection for BCOR mutations in human induced pluripotent stem cells (2021) (16)
- Genomic analysis defines clonal relationships of ductal carcinoma in situ and recurrent invasive breast cancer (2022) (16)
- Transcription-coupled repair and mismatch repair contribute towards preserving genome integrity at mononucleotide repeat tracts (2019) (16)
- Cellular survival over genomic perfection (2019) (14)
- Dissecting mutational mechanisms underpinning signatures caused by replication errors and endogenous DNA damage (2020) (13)
- Corrigendum: Signatures of mutational processes in human cancer (2013) (13)
- Basal expression of RAD51 foci predicts olaparib response in patient-derived ovarian cancer xenografts (2021) (10)
- Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences (2019) (10)
- Whole-Genome Sequencing of Retinoblastoma Reveals the Diversity of Rearrangements Disrupting RB1 and Uncovers a Treatment-Related Mutational Signature (2021) (9)
- Two Secreted Proteoglycans, Activators of Urothelial Cell–Cell Adhesion, Negatively Contribute to Bladder Cancer Initiation and Progression (2020) (8)
- FANCD2-Associated Nuclease 1 Partially Compensates for the Lack of Exonuclease 1 in Mismatch Repair (2021) (7)
- Abstract 2: Metabolomics analysis reveals distinct profiles of non-muscle invasive and muscle-invasive bladder cancer (2016) (7)
- Adrenal-permissive HSD3B1 genetic inheritance and risk of estrogen-driven postmenopausal breast cancer (2021) (7)
- Holistic cancer genome profiling for every patient. (2020) (7)
- Cardiac glycosides inhibit detubulation in amphibian skeletal muscle fibres exposed to osmotic shock (2004) (7)
- Corrigendum: Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells. (2016) (6)
- Ring chromosome 12 with inverted microduplication of 12p13.3 involving the Von Willebrand Factor gene associated with cryptogenic stroke in a young adult male. (2011) (6)
- 5 Proffered Paper: The Life History of 21 Breast Cancers (2012) (6)
- Genomic profiling defines variable clonal relatedness between invasive breast cancer and primary ductal carcinoma in situ (2021) (6)
- From genome integrity to cancer (2019) (5)
- Erratum: The Life History of 21 Breast Cancers (Cell 149 (994-1007)) (2015) (5)
- Learning to distinguish progressive and non-progressive ductal carcinoma in situ (2022) (5)
- Supplementary file 3. (2014) (4)
- 1O Detection of homologous recombination repair deficiency (HRD) in treatment-naive early triple-negative breast cancer (TNBC) by RAD51 foci and comparison with DNA-based tests (2021) (4)
- Bullying investigations need a code of conduct (2019) (4)
- Analysis of Mutational Signatures Suggest That Aid Has an Early and Driver Role in Multiple Myeloma (2016) (4)
- Functional RECAP (REpair CAPacity) assay identifies homologous recombination deficiency undetected by DNA-based BRCAness tests (2022) (4)
- Insights into cancer biology through next-generation sequencing. (2014) (4)
- Supplementary file 1. (2015) (4)
- The integrated genomic and immune landscapes of lethal metastatic breast cancer (MBC). (2018) (3)
- Targeting the DNA Damage Response Pathways and Replication Stress in Colorectal Cancer (2022) (3)
- Keipert syndrome: two further cases and review of the literature. (2008) (3)
- A living biobank of canine mammary tumor organoids as a comparative model for human breast cancer (2022) (2)
- Supplementary file 2. (2014) (2)
- Signal: The home page of mutational signatures (2019) (2)
- 604 Cancer Genomics, Epigenetics and Genomic Instability. Mutational Processes Shaping the Genomes of Twenty-one Breast Cancers (2012) (2)
- Author Correction: A practical framework and online tool for mutational signature analyses show intertissue variation and driver dependencies (2020) (2)
- Author response: DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis (2013) (2)
- Adrenal-permissive HSD3B1 genetic inheritance and risk of estrogen-driven postmenopausal breast cancer. (2021) (2)
- Research culture must be kinder for all, not just royalty (2019) (1)
- Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences (2019) (1)
- Characterization of different foci of multifocal breast cancer using genomic, transcriptomic and epigenomic data (2012) (1)
- Whole-genome sequencing of triple-negative breast cancers in a population-based clinical study (2019) (1)
- Author Correction: A practical guide for mutational signature analysis in hematological malignancies (2019) (1)
- 11 The heterogeneous genomic and immune landscapes of lethal metastatic breast cancer (2018) (1)
- The genomic landscape of metastatic breast cancer highlights changes in mutation and signature frequencies (2019) (1)
- Author Correction: Pan-cancer analysis of whole genomes (2023) (1)
- Abstract P4-15-13: When is cancer not really cancer? The PREvent ductal carcinoma in situ invasive overtreatment now (PRECISION)* initiative (2018) (1)
- Corrigendum: Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone (2014) (1)
- Abstract CT135: Uncovering the genomic heterogeneity of multifocal breast cancer (2015) (1)
- Corrigendum: A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers (2017) (1)
- Epigenetic dysregulation underpins tumorigenesis in a cutaneous tumor syndrome (2019) (1)
- Abstract IA19: A compendium of mutational signatures due to environmental exposures (2020) (1)
- A path inspired by people (2019) (1)
- Author Correction: A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns (2020) (1)
- The duty to speak up (2018) (0)
- Exploring the subclonal architecture of breast cancer (2012) (0)
- PO-339 Implications of organ-wise extraction of cancer mutational signatures using 2577 whole genomes (2018) (0)
- Abstract IA01: Advancing the field of mutational signatures: Mechanisms and clinical applications (2017) (0)
- Abstract 611: AID/APOBEC cytidine deaminases can mimic the phenomenon of localized hypermutation in cancer orkataegis. (2013) (0)
- From genome integrity to cancer (2019) (0)
- Whole-genome-sequencing of triple negative breast cancers: a population study (2019) (0)
- Abstract P5-10-01: Using whole genome sequencing and somatic mutation signatures to unravel insight into familial breast cancer aetiology (2019) (0)
- Abstract LB-262: A somatic-mutational process in breast cancer genomes recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers (2017) (0)
- HRDetect : A mutational signature based predictor of BRCA 1 and BRCA 2 deficiency (2017) (0)
- Abstract PR006: A living biobank of patient-derived ductal carcinoma in situ (DCIS) Mouse-INtraDuctal (MIND) xenografts identifies multiple risk factors of invasive progression (2022) (0)
- Abstract 5108: Copy number analysis of pure DCIS and association with recurrence (2022) (0)
- Abstract 4978: On circular RNAs in breast cancer (2018) (0)
- Abstract PL2: Advances in the understanding and the applications of mutational signatures in human cells (2018) (0)
- Tubio retrotransposition in cancer genomes Extensive transduction of nonrepetitive DNA mediated by L 1 (2014) (0)
- Genomic characterisation of hormone receptor-positive breast cancer arising in very young women. (2023) (0)
- Familial adrenocortical carcinoma associated with HNPCC (2011) (0)
- Ductal carcinoma in situ: to treat or not to treat, that is the question (2019) (0)
- Validating the concept of mutational signatures with isogenic cell models (2018) (0)
- Abstract P6-08-10: Mutational signatures impact the breast cancer transcriptome and distinguish mitotic from immune response pathways (2016) (0)
- Abstract 5055: Exploring the subclonal architecture of breast cancer (2012) (0)
- The genome as a record for environmental exposure to polycyclic aromatic hydrocarbons (2017) (0)
- Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation (2019) (0)
- ArticleTwo Secreted Proteoglycans (2020) (0)
- Large-scale genomic analysis of human iPSCs identifies recurrent somatic driver mutations (2022) (0)
- Abstract 534: Functional drug screening of organoids from ovarian cancer patients demonstrates clinical and genomic concordance and identifies novel therapeutic vulnerabilities (2021) (0)
- Abstract PL02-02: Harnessing the value of mutational signatures in whole cancer genomes (2021) (0)
- Author Correction: The evolutionary history of 2,658 cancers (2023) (0)
- Whole Exome Sequencing Of Multiple Myeloma Reveals An Heterogeneous Clonal Architecture and Genomic Evolution (2013) (0)
- A compendium of mutational signatures of environmental and chemotherapeutic agents Kucab et al. (2019) (0)
- Abstract P1-22-05: Identifying predictors of invasive recurrence based on molecular profiles of DCIS lesions (2022) (0)
- Author Correction: Inferring structural variant cancer cell fraction (2022) (0)
- Non-BRCA1/BRCA2 High-Risk Familial Breast Cancers are Not Associated with a High Prevalence of BRCAness (2021) (0)
- The duty to speak up (2018) (0)
- Mutational signatures: experimental design and analytical framework (2020) (0)
- Abstract MS1-2: Genomics of DNA repair defects in breast cancer (2022) (0)
- Low rates of mutation in clinical grade human pluripotent stem cells under different culture conditions (2020) (0)
- Transcription-coupled repair and mismatch repair contribute towards preserving genome integrity at mononucleotide repeat tracts (2020) (0)
- ESMO Recommendations on Homologous Recombination Deficiency Testing to Predict PARP Inhibitor Benefit in Ovarian Cancer (2020) (0)
- Abstract P3-09-18: The association between genomic alterations and body mass index in patients with early breast cancer (2022) (0)
- Abstract 4887: Direct mutational consequences of CRISPR-cas9 gene-edited DNA repair genes (2020) (0)
- Abstract P1-05-02: Genomic, transcriptomic and immune features of breast cancer according to the patient's body mass index at diagnosis (2017) (0)
- Abstract CN05-01: DNA damage signatures and practical use (2018) (0)
- Homologous recombination DNA repair deficiency and PARP inhibition activity in primary triple negative breast cancer (2020) (0)
- Abstract PR002: Genomic predictor can discriminate between high- and low-risk DCIS (2022) (0)
- Basal expression of RAD51 foci predicts olaparib response in patient-derived ovarian cancer xenografts (2021) (0)
- Author Correction: Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples (2020) (0)
- Kataegis and other somatic mutational signatures in cancer (2013) (0)
- Whole-genome sequencing of triple negative breast cancers in a standard population-based clinical setting (2020) (0)
- A living biobank of patient-derived ductal carcinoma in situ mouse-intraductal xenografts identifies risk factors for invasive progression. (2023) (0)
- 462: Mutational characterisation of 400 breast cancers genomes (2014) (0)
- HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures (2017) (0)
- Author Correction: Patterns of somatic structural variation in human cancer genomes (2020) (0)
- Author Correction: Learning to distinguish progressive and non-progressive ductal carcinoma in situ (2022) (0)
- Abstract 5143: From sequencing data to mutation spectra: a high throughput analysis pipeline. (2013) (0)
- Author Correction: A practical guide for mutational signature analysis in hematological malignancies (2019) (0)
- Title A mutational signature in gastric cancer suggests therapeuticstrategies (2015) (0)
- Abstract 805: RECAP (REpair CAPacity) identifies a subset of breast cancers unable to form RAD51 foci which are undetected by DNA-based BRCAness tests (2022) (0)
- The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models (2013) (0)
- 277 DNMT3A is an epigenetic negative regulator of Wnt/ß-catenin pathway signalling in CYLD cutaneous syndrome (2019) (0)
- Abstract 3259: When is cancer not really cancer: The PREvent Ductal Carcinoma In Situ Invasive Overtreatment Now (PRECISION)* initiative (2018) (0)
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What Schools Are Affiliated With Serena Nik-Zainal?
Serena Nik-Zainal is affiliated with the following schools:
