Sérgio Pena
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Brazilian physician
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Sérgio Pena biology Degrees
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#10491
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Genetics
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Sérgio Pena philosophy Degrees
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Biology Philosophy
Sérgio Pena 's Degrees
- Bachelors Medicine Federal University of Minas Gerais
- PhD Genetics University of São Paulo
Why Is Sérgio Pena Influential?
(Suggest an Edit or Addition)According to Wikipedia, Sérgio Danilo Junho Pena is a Brazilian human geneticist and professor in the Department of Biochemistry and Immunology at the Federal University of Minas Gerais in Belo Horizonte, Brazil. He began researching the population genetics of the Brazilian population in the late 1980s. His research on this subject has highlighted the ways that physical characteristics of Brazilians are often discordant with their genetic ancestry. On the basis of his research showing extensive genetic diversity in the Brazilian population, he has vocally advocated for the view that race is a social construct rather than a biological reality. For instance, he received significant media coverage when he led a research team which analyzed the genetic profiles of nine prominent black Brazilian celebrities in May 2007 for a project organized by BBC Brasil. The results showed that one of these celebrities, Neguinho da Beija-Flor, had predominantly European ancestry despite identifying as black. He was described as "one of Brazil’s best-known and most media-savvy geneticists" in a 2015 academic journal article.
Sérgio Pena 's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Color and genomic ancestry in Brazilians (2002) (914)
- The ancestry of Brazilian mtDNA lineages. (2000) (619)
- Trypanosoma cruzi: genetic structure of populations and relevance of genetic variability to the pathogenesis of chagas disease. (2004) (280)
- Genetic characterization of Trypanosoma cruzi directly from tissues of patients with chronic Chagas disease: differential distribution of genetic types into diverse organs. (2000) (251)
- Ancestral Genomes, Sex, and the Population Structure of Trypanosoma cruzi (2006) (241)
- Genetic Variability of Trypanosoma cruzi:Implications for the Pathogenesis of Chagas Disease. (1998) (228)
- Probing the genetic population structure of Trypanosoma cruzi with polymorphic microsatellites. (1998) (188)
- DNA tests probe the genomic ancestry of Brazilians. (2009) (170)
- Color and Genomic Ancestry in Brazilians: A Study with Forensic Microsatellites (2006) (157)
- Differential tissue distribution of diverse clones of Trypanosoma cruzi in infected mice. (1999) (156)
- Virus-Host Coevolution: Common Patterns of Nucleotide Motif Usage in Flaviviridae and Their Hosts (2009) (145)
- Chagas' disease diagnosis: comparative analysis of parasitologic, molecular, and serologic methods. (1999) (143)
- Trypanosoma cruzi: optimization of polymerase chain reaction for detection in human blood. (1998) (139)
- DNA fingerprinting of Trypanosoma cruzi: a new tool for characterization of strains and clones. (1992) (122)
- Identification of new Schistosoma mansoni genes by the EST strategy using a directional cDNA library. (1995) (113)
- Kinetoplast DNA signatures of Trypanosoma cruzi strains obtained directly from infected tissues. (1996) (111)
- Phylogeography of the human mitochondrial haplogroup L3e: a snapshot of African prehistory and Atlantic slave trade (2001) (100)
- The random amplification of polymorphic DNA allows the identification of strains and species of schistosome. (1993) (99)
- Color, Race, and Genomic Ancestry in Brazil (2009) (99)
- Up-regulation of the error-prone DNA polymerase {kappa} promotes pleiotropic genetic alterations and tumorigenesis. (2005) (98)
- Trypanosoma cruzi: role of host genetic background in the differential tissue distribution of parasite clonal populations. (2002) (86)
- Pharmacogenomics in the Americas: the impact of genetic admixture. (2006) (84)
- Real time PCR strategy for the identification of major lineages of Trypanosoma cruzi directly in chronically infected human tissues. (2005) (80)
- Razões para banir o conceito de raça da medicina brasileira (2005) (76)
- Relationship between Trypanosoma cruzi and human chagasic megaesophagus: blood and tissue parasitism. (2001) (75)
- Sequence-specific "gene signatures" can be obtained by PCR with single specific primers at low stringency. (1994) (72)
- Unveiling Benznidazole's mechanism of action through overexpression of DNA repair proteins in Trypanosoma cruzi (2014) (71)
- Pode a genética definir quem deve se beneficiar das cotas universitárias e demais ações afirmativas (2004) (71)
- The Phylogeography of African Brazilians (2007) (70)
- Self-reported skin color, genomic ancestry and the distribution of GST polymorphisms (2007) (69)
- Niger-Congo speaking populations and the formation of the Brazilian gene pool: mtDNA and Y-chromosome data. (2007) (69)
- Oxidative Stress and DNA Lesions: The Role of 8-Oxoguanine Lesions in Trypanosoma cruzi Cell Viability (2013) (66)
- Evaluation of cDNA libraries from different developmental stages of Schistosoma mansoni for production of expressed sequence tags (ESTs). (1997) (65)
- Two ancient human genomes reveal Polynesian ancestry among the indigenous Botocudos of Brazil (2014) (64)
- Leishmania (Viannia) braziliensis: genetic relationships between strains isolated from different areas of Brazil as revealed by DNA fingerprinting and RAPD. (1995) (64)
- Usefulness of microsatellite typing in population genetic studies of Trypanosoma cruzi. (2001) (61)
- PCR amplification of the mitochondrial DNA minisatellite region to detect Schistosoma mansoni infection in Biomphalaria glabrata snails. (1997) (57)
- Tracing the genomic ancestry of Peruvians reveals a major legacy of pre-Columbian ancestors (2013) (57)
- No association found between gr/gr deletions and infertility in Brazilian males. (2006) (57)
- Pharmacogenomic Diversity among Brazilians: Influence of Ancestry, Self-Reported Color, and Geographical Origin (2012) (55)
- Genetic profiling of Trypanosoma cruzi directly in infected tissues using nested PCR of polymorphic microsatellites. (2008) (54)
- Microsatellite instability as a tool for the classification of gastric cancer. (2001) (54)
- An alternative approach to evaluating the intraspecific genetic variability of parasites. (1997) (52)
- Pre- and Post-Columbian Gene and Cultural Continuity: The Case of the Gaucho from Southern Brazil (2007) (52)
- Global pharmacogenomics: Impact of population diversity on the distribution of polymorphisms in the CYP2C cluster among Brazilians (2010) (51)
- Characterization of the Trypanosoma cruzi Rad51 gene and its role in recombination events associated with the parasite resistance to ionizing radiation. (2006) (50)
- Variability of Kinetoplast DNA Gene Signatures of Trypanosoma cruzi II Strains from Patients with Different Clinical Forms of Chagas' Disease in Brazil (2006) (50)
- Low-stringency single specific primer PCR for identification of Leptospira. (2003) (50)
- Differential tissue tropism of Trypanosoma cruzi strains: an in vitro study. (2010) (49)
- DNA fingerprints: a tool for identification and determination of the relationships between species and strains of Leishmania. (1992) (49)
- Distribution of CYP2D6 Alleles and Phenotypes in the Brazilian Population (2014) (48)
- Association of Genetic Variants with Self-Assessed Color Categories in Brazilians (2014) (46)
- Analysis of the gene expression profile of Schistosoma mansoni cercariae using the expressed sequence tag approach. (1999) (45)
- Coinfection with Different Trypanosoma cruzi Strains Interferes with the Host Immune Response to Infection (2010) (45)
- Genetic relationships between Trypanosoma cruzi strains isolated from chronic chagasic patients in southern Brazil as revealed by RAPD and SSR-PCR analysis. (1998) (45)
- Impact of population admixture on the distribution of the CYP3A5*3 polymorphism. (2007) (43)
- Minilibraries constructed from cDNA generated by arbitrarily primed RT-PCR: an alternative to normalized libraries for the generation of ESTs from nanogram quantities of mRNA. (1997) (42)
- Lack of association between Y chromosome haplogroups and male infertility in Japanese men (2003) (41)
- DNA polymerase kappa from Trypanosoma cruzi localizes to the mitochondria, bypasses 8‐oxoguanine lesions and performs DNA synthesis in a recombination intermediate (2009) (41)
- Identification of Polynesian mtDNA haplogroups in remains of Botocudo Amerindians from Brazil (2013) (40)
- Kinetoplast DNA from Trypanosoma rangeli contains two distinct classes of minicircles with different size and molecular organization. (1994) (40)
- Influence of genomic ancestry on the distribution of SLCO1B1, SLCO1B3 and ABCB1 gene polymorphisms among Brazilians. (2012) (38)
- DNA bioprints: Simple nonisotopic DNA fingerprints with biotinylated probes (1991) (38)
- Intracellular promiscuity in Schistosoma mansoni: nuclear transcribed DNA sequences are part of a mitochondrial minisatellite region. (1995) (38)
- Characterization of promoter regulatory elements involved in downexpression of the DNA polymerase κ in colorectal cancer (2007) (36)
- Global Pharmacogenomics: Distribution of CYP3A5 Polymorphisms and Phenotypes in the Brazilian Population (2014) (35)
- The population structure of Trypanosoma cruzi: expanded analysis of 54 strains using eight polymorphic CA-repeat microsatellites. (1999) (34)
- Cell culture and animal infection with distinct Trypanosoma cruzi strains expressing red and green fluorescent proteins. (2008) (33)
- Functional Characterization of 8-Oxoguanine DNA Glycosylase of Trypanosoma cruzi (2012) (33)
- Yeast artificial chromosome (YAC)-based genome mapping of Schistosoma mansoni. (1995) (33)
- DNA fingerprinting reveals relationships between strains of Trypanosoma rangeli and Trypanosoma cruzi. (1993) (32)
- The MHC Gene Region of Murine Hosts Influences the Differential Tissue Tropism of Infecting Trypanosoma cruzi Strains (2009) (31)
- Evidence of substantial recombination among Trypanosoma cruzi II strains from Minas Gerais. (2014) (30)
- The genetic structure of human populations studied through short insertion-deletion polymorphisms. (2006) (29)
- Biochemical studies with DNA polymerase beta and DNA polymerase beta-PAK of Trypanosoma cruzi suggest the involvement of these proteins in mitochondrial DNA maintenance. (2008) (29)
- New native South American Y chromosome lineages (2016) (27)
- Mitochondrial D-loop "signatures" produced by low-stringency single specific primer PCR constitute a simple comparative human identity test. (1996) (27)
- Extraction of DNA from human skeletal remains: practical applications in forensic sciences. (1997) (27)
- Characterization of a Schistosoma mansoni gene encoding a homologue of the Y-box binding protein. (1997) (26)
- Homo brasilis : aspectos genéticos, lingüísticos, históricos e socioantropológicos da formação do povo brasileiro (2002) (26)
- Frequent detection of parental consanguinity in children with developmental disorders by a combined CGH and SNP microarray (2013) (26)
- DNA polymerase beta from Trypanosoma cruzi is involved in kinetoplast DNA replication and repair of oxidative lesions. (2012) (25)
- Early polymerase chain reaction detection of Chagas disease reactivation in heart transplant patients. (2017) (25)
- Trypanosoma cruzi: ancestral genomes and population structure. (2009) (24)
- A inexistência biológica versus a existência social de raças humanas: pode a ciência instruir o etos social? (2006) (23)
- Application of the F(ST) statistics to explore pharmacogenomic diversity in the Brazilian population. (2012) (22)
- Cloning and characterization of DNA polymerase η from Trypanosoma cruzi: Roles for translesion bypass of oxidative damage (2009) (22)
- Unequivocal Identification of Subpopulations in Putative Multiclonal Trypanosoma cruzi Strains by FACs Single Cell Sorting and Genotyping (2012) (21)
- The use of RAPDs for the analysis of parasites. (1993) (21)
- VKORC1 polymorphisms in Brazilians: comparison with the Portuguese and Portuguese-speaking Africans and pharmacogenetic implications. (2010) (21)
- The recombinase Rad51 plays a key role in events of genetic exchange in Trypanosoma cruzi (2018) (20)
- The use of RAPDs for the study of the genetic diversity of Schistosoma mansoni and Trypanosoma cruzi. (1993) (18)
- Mismatch repair in Trypanosoma brucei: heterologous expression of MSH2 from Trypanosoma cruzi provides new insights into the response to oxidative damage. (2008) (18)
- An approach to human papillomavirus identification using low stringency single specific primer PCR. (1995) (17)
- Y-box binding protein from Schistosoma mansoni: interaction with DNA and RNA. (2002) (16)
- Clustering of Schistosoma mansoni mRNA sequences and analysis of the most transcribed genes: implications in metabolism and biology of different developmental stages. (2002) (16)
- Multiple geographic sources of region V 9-bp deletion haplotypes in Brazilians. (1999) (16)
- Sex-biased gene flow in African Americans but not in American Caucasians. (2007) (16)
- Catalase expression impairs oxidative stress-mediated signalling in Trypanosoma cruzi (2017) (16)
- Characterization and comparative functional analysis in yeast of a Schistosoma mansoni Rho1 GTPase gene. (2002) (15)
- Host-related DNA sequences in the schistosome genome? (1991) (15)
- The Influence of Recombinational Processes to Induce Dormancy in Trypanosoma cruzi (2020) (15)
- DNA polymorphism of schistosomes and their snail hosts. (1995) (15)
- F10, the gene for the glycine-rich major eggshell protein of Schistosoma mansoni recognizes a family of hypervariable minisatellites in the human genome. (1990) (14)
- A simple non-isotopic method for DNA fingerprinting with M13 phage. (1988) (13)
- The in vivo and in vitro roles of Trypanosoma cruzi Rad51 in the repair of DNA double strand breaks and oxidative lesions (2018) (12)
- Lactate dehydrogenase: sequence and analysis of its expression during the life cycle of Schistosoma mansoni. (1998) (12)
- A general method for efficient non-isotopic labeling of DNA probes cloned in M13 vectors: application to DNA fingerprinting. (1989) (12)
- Detection of CYP2C9*5 in a White Brazilian Subject (2005) (12)
- Recovering mitochondrial DNA lineages of extinct Amerindian nations in extant homopatric Brazilian populations (2010) (12)
- The fallacy of racial pharmacogenomics. (2011) (11)
- Evidentiation of paramyosin (Sm-97) as a modulating antigen on granulomatous hypersensitivity to Schistosoma mansoni eggs. (1997) (11)
- Schistosoma mansoni: Heterologous complementation of a yeast null mutant by SmRbx, a protein similar to a RING box protein involved in ubiquitination. (2007) (11)
- Analysis of DNA polymerase activity in vitro using non-radioactive primer extension assay in an automated DNA sequencer. (2007) (10)
- Effect of ionizing radiation exposure on Trypanosoma cruzi ubiquitin-proteasome system. (2017) (9)
- Identification in Portugal and Brazil of a mtDNA Lineage Containing a 9-bp Triplication of the Intergenic COII/tRNALys Region (1999) (9)
- Molecular Characterization of the Schistosoma mansoni Zinc Finger Protein SmZF1 as a Transcription Factor (2009) (9)
- Assessment of genetic mutation frequency induced by oxidative stress in Trypanosoma cruzi (2018) (9)
- Update of the gene discovery program in Schistosoma mansoni with the expressed sequence tag approach. (1997) (8)
- A simple laboratory method for distinguishing between Trypanosoma cruzi and Trypanosoma rangeli. (1993) (8)
- DNA Topoisomerase 3α Is Involved in Homologous Recombination Repair and Replication Stress Response in Trypanosoma cruzi (2021) (7)
- Schistosoma mansoni: the IMP4 gene is involved in DNA repair/tolerance after treatment with alkylating agent methyl methane sulfonate. (2007) (7)
- Biochemical and immunochemical identification of the fetal polypeptides of human amniotic fluid during the second trimester of pregnancy. (1990) (7)
- A probability model for the meiosis I non‐disjunction fraction in numerical chromosomal anomalies (2003) (7)
- Cloning and molecular characterization of the Schistosoma mansoni genes RbAp48 and histone H4. (2002) (7)
- Sequencing and identification of expressed Schistosoma mansoni genes by random selection of cDNA clones from a directional library. (1995) (7)
- The schistosome genome project: RNA arbitrarily primed PCR allows the accelerated generation of expressed sequence tags. (1996) (7)
- Characterization of a Schistosoma mansoni homologue of the gene encoding the breast basic conserved protein 1/L13 ribosomal protein. (1998) (5)
- Functional complementation of a yeast knockout strain by Schistosoma mansoni Rho1 GTPase in the presence of caffeine, an agent that affects mutants defective in the protein kinase C signal transduction pathway. (2006) (5)
- The Biological Nonexistence versus the Social Existence of Human Races: Can Science Instruct the Social Ethos? (2011) (5)
- Nucleic acid binding properties of SmZF1, a zinc finger protein of Schistosoma mansoni. (2004) (5)
- M13 Bioprints: non-isotopic detection of individual-specific human DNA fingerprints with biotinylated M13 bacteriophage. (1989) (5)
- Human papillomavirus detection in cervical dysplasias or neoplasias and in condylomata acuminata by in situ hybridization with biotinylated DNA probes. (1992) (4)
- Identification of genes encoding Schistosoma mansoni antigens using an antigenic sequence tag strategy. (1998) (4)
- O estado da ciência no Brasil: como dar um salto de qualidade? (2012) (3)
- UTILIZAÇÃO DE POLIMORFISMOS DE DNA DO CROMOSSOMO Y NO ESTUDO DO POVOAMENTO DAS AMÉRICAS (1997) (3)
- Partially degraded DNA of parasitological interest serves as an adequate template for the production of random amplified polymorphic DNAs (RAPDs). (1997) (3)
- LSSP-PCR of Trypanosoma cruzi: how the single primer sequence affects the kDNA signature (2013) (3)
- Characterization of an abundant Schistosoma mansoni transcript with no homologs in the databases. (1998) (3)
- Para remover a palavra raça dos prontuários médicos no Brasil (2007) (3)
- Conflitos paradigmáticos e a ética do Projeto Genoma Humano (1995) (3)
- O DNA como (Única) Testemunha em Determinação de Paternidade (2009) (3)
- Molecular biological techniques for the diagnosis of infectious diseases. (1992) (2)
- Identification of Stage‐Specific Genes in Schistosoma mansoni (2000) (2)
- O triste caso do vestibular da Universidade de Brasília (2005) (2)
- LSSP-PCR of Trypanosoma cruzi: how the single primer sequence affects the kDNA signature (2013) (1)
- Recognizing the unconscious (2014) (1)
- Isolation and characterization of HC1: a novel human DNA repair gene. (2009) (1)
- Frequent detection of parental consanguinity in children with developmental disorders by a combined CGH and SNP microarray (2013) (1)
- Sequencing and expression analysis of a Schistosoma mansoni gene homologue to a Drosophila gene involved in germ plasm assembly. (1998) (1)
- Erratum: New native South American Y chromosome lineages (2016) (0)
- Reply to Rothhammer and Moraga (2001) (0)
- RESEARCH NOTE - Characterization of an Abundant Schistosoma mansoniTranscript with No Homologs in the Databases (1998) (0)
- Peeking into the mysterious world of Trypanosoma cruzi and Chagas disease (2022) (0)
- Mendel,MD: a user-friendly online program for clinical exome analysis (2015) (0)
- Contents Vol. 62, 2006 (2006) (0)
- Subject Index Vol. 62, 2006 (2006) (0)
- DNA and the criminal justice system: The technology of justice. Edited by David Lazer. MIT Press, Cambridge, Massachusetts, 2004, 414 p. (2007) (0)
- RESEARCH NOTE - Lactate Dehydrogenase: Sequence and Analysis of itsExpression during the Life Cycle of Schistosoma mansoni (1998) (0)
- The recombinase Rad51 plays a key role in events of genetic exchange in Trypanosoma cruzi (2018) (0)
- Negros, mas nem tão africanos (2006) (0)
- ARTIGO DE REVISÃO MOLECULAR BIOLOGICAL TECHNIQUES FOR THE DIAGNOSIS OF INFECTIOUS DISEASES (2013) (0)
- Mitochondrial D-loop {open_quotes}signatures{close_quotes} produced by low-stringency single specific primer PCR constitute a simple comparative human identity test (1996) (0)
- Indication of a biparental mitochondrial DNA inheritance in Schistosoma mansoni (1997) (0)
- Cloning and Molecular Characterization of the Schistosoma mansoni Genes RbAp 48 and Histone H 4 (0)
- Analysis of a cDNA clone encoding a S. mansoni annexin (1999) (0)
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Sérgio Pena is affiliated with the following schools:
