Shahriar Mobashery

Shahriar Mobashery's AcademicInfluence.com Rankings

Shahriar Mobashery

Chemistry

#2959

World Rank

#3936

Historical Rank

Polymer Chemistry

#75

World Rank

#78

Historical Rank

Chemical Engineering

#317

World Rank

#331

Historical Rank

Organic Chemistry

#455

World Rank

#531

Historical Rank

chemistry Degrees

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Chemistry

Shahriar Mobashery's Degrees

PhD Chemistry University of California, Berkeley
Masters Chemical Engineering Stanford University
Bachelors Chemical Engineering Stanford University

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Shahriar Mobashery's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Matrix metalloproteinases: structures, evolution, and diversification (1998) (757)
Bacterial resistance to beta-lactam antibiotics: compelling opportunism, compelling opportunity. (2005) (698)
Tackling antibiotic resistance (2011) (653)
Versatility of Aminoglycosides and Prospects for Their Future (2003) (577)
Aminoglycosides: Perspectives on Mechanisms of Action and Resistance and Strategies to Counter Resistance (2000) (463)
Kinship and Diversification of Bacterial Penicillin-Binding Proteins and β-Lactamases (1998) (416)
A Highly Specific Inhibitor of Matrix Metalloproteinase-9 Rescues Laminin from Proteolysis and Neurons from Apoptosis in Transient Focal Cerebral Ischemia (2005) (389)
Three-dimensional structure of the bacterial cell wall peptidoglycan. (2006) (377)
Activation of progelatinase B (MMP-9) by gelatinase A (MMP-2). (1995) (353)
Kinetic Analysis of the Binding of Human Matrix Metalloproteinase-2 and -9 to Tissue Inhibitor of Metalloproteinase (TIMP)-1 and TIMP-2* (1997) (290)
Bacterial cell‐wall recycling (2013) (250)
Recent advances in MMP inhibitor design (2006) (240)
Bacterial Resistance to β‐Lactam Antibiotics: Compelling Opportunism, Compelling Opportunity (2005) (223)
Critical involvement of a carbamylated lysine in catalytic function of class D β-lactamases (2001) (210)
How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function (2013) (207)
The Basis for Resistance to β-Lactam Antibiotics by Penicillin-binding Protein 2a of Methicillin-resistant Staphylococcus aureus* (2004) (202)
β-Lactam resistance in Staphylococcus aureus: the adaptive resistance of a plastic genome (2005) (198)
Potent and Selective Mechanism-Based Inhibition of Gelatinases (2000) (186)
Substrate Hydrolysis by Matrix Metalloproteinase-9* (2001) (183)
Discoidin Domain Receptors: Unique Receptor Tyrosine Kinases in Collagen-mediated Signaling* (2013) (173)
Cell surface association of matrix metalloproteinase-9 (gelatinase B) (2003) (161)
Mechanism of anchoring of OmpA protein to the cell wall peptidoglycan of the gram‐negative bacterial outer membrane (2012) (157)
Penicillin‐binding protein 2a of methicillin‐resistant Staphylococcus aureus (2014) (157)
The future of the β-lactams. (2010) (154)
Characterization of the Monomeric and Dimeric Forms of Latent and Active Matrix Metalloproteinase-9 (2000) (148)
Ab initio QM/MM study of class A beta-lactamase acylation: dual participation of Glu166 and Lys73 in a concerted base promotion of Ser70. (2005) (146)
Aminoglycosides modified by resistance enzymes display diminished binding to the bacterial ribosomal aminoacyl-tRNA site. (2002) (144)
Design of novel antibiotics that bind to the ribosomal acyltransfer site. (2002) (136)
Tissue Inhibitor of Metalloproteinase (TIMP)-2 Acts Synergistically with Synthetic Matrix Metalloproteinase (MMP) Inhibitors but Not with TIMP-4 to Enhance the (Membrane Type 1)-MMP-dependent Activation of Pro-MMP-2* (2000) (136)
Aminoglycoside antibiotics. Structures, functions, and resistance. (1998) (133)
Molecular Basis and Phenotype of Methicillin Resistance in Staphylococcus aureus and Insights into New β-Lactams That Meet the Challenge (2009) (131)
Structural Basis for Clinical Longevity of Carbapenem Antibiotics in the Face of Challenge by the Common Class A Beta-Lactamases from Antibiotic-Resistant Bacteria (1998) (129)
Inactivation of class A β-lactamases by clavulanic acid : the role of arginine-244 in a proposed nonconcerted sequence of events (1993) (129)
Antimetastatic activity of a novel mechanism-based gelatinase inhibitor. (2005) (125)
Cell-Wall Recycling of the Gram-Negative Bacteria and the Nexus to Antibiotic Resistance. (2018) (124)
Effect of ablation or inhibition of stromal matrix metalloproteinase-9 on lung metastasis in a breast cancer model is dependent on genetic background. (2008) (124)
Potent Mechanism-based Inhibitors for Matrix Metalloproteinases* (2005) (123)
Complex Pattern of Membrane Type 1 Matrix Metalloproteinase Shedding (2002) (120)
Aminoglycoside-modifying enzymes: mechanisms of catalytic processes and inhibition. (2001) (117)
Co-opting the cell wall in fighting methicillin-resistant Staphylococcus aureus: potent inhibition of PBP 2a by two anti-MRSA beta-lactam antibiotics. (2008) (112)
Elucidation of the role of arginine-244 in the turnover processes of class A beta-lactamases. (1992) (110)
Synergistic, collaterally sensitive β-lactam combinations suppress resistance in MRSA (2015) (110)
Acceleration of diabetic wound healing using a novel protease–anti-protease combination therapy (2015) (107)
Dynamics of the Lipopolysaccharide Assembly on the Surface of Escherichia coli (1999) (107)
Short Alkylated Peptoid Mimics of Antimicrobial Lipopeptides (2010) (104)
Discovery of a New Class of Non-β-lactam Inhibitors of Penicillin-Binding Proteins with Gram-Positive Antibacterial Activity (2014) (103)
Insights into class D beta-lactamases are revealed by the crystal structure of the OXA10 enzyme from Pseudomonas aeruginosa. (2000) (103)
Discovery of antibiotic (E)-3-(3-carboxyphenyl)-2-(4-cyanostyryl)quinazolin-4(3H)-one. (2015) (101)
The use of triphosgene in preparation of N-carboxy .alpha.-amino acid anhydrides (1992) (99)
Lytic transglycosylases: concinnity in concision of the bacterial cell wall (2017) (97)
Inhibition of MMP-9 by a selective gelatinase inhibitor protects neurovasculature from embolic focal cerebral ischemia (2012) (95)
Selective Inhibition of Matrix Metalloproteinase-9 Attenuates Secondary Damage Resulting from Severe Traumatic Brain Injury (2013) (92)
Inhibition of human prostate cancer growth, osteolysis and angiogenesis in a bone metastasis model by a novel mechanism‐based selective gelatinase inhibitor (2006) (88)
Structural basis for carbapenemase activity of the OXA-23 β-lactamase from Acinetobacter baumannii. (2013) (88)
The basis for resistance to beta-lactam antibiotics by penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus. (2004) (87)
Crystal Structure of 6Alpha-Hydroxymethylpenicillanate Complexed to the Tem-1 Beta-Lactamase from Escherichia Coli: Evidence on the Mechanism of Action of a Novel Inhibitor Designed by a Computer-Aided Process (1996) (84)
A 1.2-A snapshot of the final step of bacterial cell wall biosynthesis. (2001) (82)
Structure–Activity Relationship for the 4(3H)-Quinazolinone Antibacterials (2016) (82)
Messenger functions of the bacterial cell wall-derived muropeptides. (2012) (82)
Extracellular proteases as targets for treatment of cancer metastases. (2004) (82)
Molecular structures and dynamics of the stepwise activation mechanism of a matrix metalloproteinase zymogen: challenging the cysteine switch dogma. (2007) (80)
Recognition of peptidoglycan and β‐lactam antibiotics by the extracellular domain of the Ser/Thr protein kinase StkP from Streptococcus pneumoniae (2011) (79)
Design, Synthesis, and Characterization of Potent, Slow-binding Inhibitors That Are Selective for Gelatinases* (2002) (78)
How β-Lactamases Have Driven Pharmaceutical Drug Discovery (1998) (78)
Shedding of Discoidin Domain Receptor 1 by Membrane-type Matrix Metalloproteinases* (2013) (77)
Reactions of all Escherichia coli lytic transglycosylases with bacterial cell wall. (2013) (76)
Synthesis and evaluation of 1,2,4-triazolo[1,5-a]pyrimidines as antibacterial agents against Enterococcus faecium. (2015) (76)
Structural insights into the bactericidal mechanism of human peptidoglycan recognition proteins (2007) (76)
The complex of a designer antibiotic with a model aminoacyl site of the 30S ribosomal subunit revealed by X-ray crystallography. (2003) (75)
Insertion of Epicatechin Gallate into the Cytoplasmic Membrane of Methicillin-resistant Staphylococcus aureus Disrupts Penicillin-binding Protein (PBP) 2a-mediated β-Lactam Resistance by Delocalizing PBP2* (2010) (71)
Pharmacological Stabilization of Intracranial Aneurysms in Mice: A Feasibility Study (2012) (70)
A chemical biological strategy to facilitate diabetic wound healing. (2014) (70)
Prostate cancer-associated membrane type 1-matrix metalloproteinase: a pivotal role in bone response and intraosseous tumor growth. (2007) (70)
The sentinel role of peptidoglycan recycling in the β-lactam resistance of the Gram-negative Enterobacteriaceae and Pseudomonas aeruginosa. (2014) (70)
Structure-activity relationship for the oxadiazole class of antibiotics. (2015) (70)
Activation for catalysis of penicillin-binding protein 2a from methicillin-resistant Staphylococcus aureus by bacterial cell wall. (2005) (70)
A structure-based analysis of the inhibition of class A beta-lactamases by sulbactam. (1994) (69)
Structural aspects for evolution of beta-lactamases from penicillin-binding proteins. (2003) (69)
The Importance of a Critical Protonation State and the Fate of the Catalytic Steps in Class A β-Lactamases and Penicillin-binding Proteins* (2004) (69)
Structural consequences of the inhibitor-resistant Ser130Gly substitution in TEM beta-lactamase. (2005) (68)
Resistance to β-Lactam Antibiotics and Its Mediation by the Sensor Domain of the Transmembrane BlaR Signaling Pathway in Staphylococcus aureus * 210 (2003) (68)
Quest for selectivity in inhibition of matrix metalloproteinases. (2004) (67)
Crystal structures of penicillin-binding protein 6 from Escherichia coli. (2009) (65)
Roles of Matrix Metalloproteinases in Flow-Induced Outward Vascular Remodeling (2009) (65)
Structural and Functional Insights into Peptidoglycan Access for the Lytic Amidase LytA of Streptococcus pneumoniae (2014) (64)
Insights into pneumococcal fratricide from the crystal structures of the modular killing factor LytC (2010) (64)
Disruption of Allosteric Response as an Unprecedented Mechanism of Resistance to Antibiotics (2014) (64)
Effects on Substrate Profile by Mutational Substitutions at Positions 164 and 179 of the Class A TEMpUC19 β-Lactamase from Escherichia coli* (1999) (63)
Effect of synthetic matrix metalloproteinase inhibitors on lipopolysaccharide-induced blood–brain barrier opening in rodents: Differences in response based on strains and solvents (2007) (63)
Mechanistic Basis for the Emergence of Catalytic Competence against Carbapenem Antibiotics by the GES Family of β-Lactamases (2009) (63)
Elucidation of the Molecular Recognition of Bacterial Cell Wall by Modular Pneumococcal Phage Endolysin CPL-1* (2007) (61)
High-resolution X-ray structure of an acyl-enzyme species for the class D OXA-10, β-lactamase (2002) (61)
Three Decades of the Class A β-Lactamase Acyl-Enzyme (2009) (59)
Resolving the antibiotic paradox: progress in understanding drug resistance and development of new antibiotics. (1998) (59)
Selection and Characterization of β-Lactam–β-Lactamase Inactivator-Resistant Mutants following PCR Mutagenesis of the TEM-1 β-Lactamase Gene (1998) (59)
Matrix metalloproteinase 2 inhibition: combined quantum mechanics and molecular mechanics studies of the inhibition mechanism of (4-phenoxyphenylsulfonyl)methylthiirane and its oxirane analogue. (2009) (58)
Activation of BlaR1 Protein of Methicillin-resistant Staphylococcus aureus, Its Proteolytic Processing, and Recovery from Induction of Resistance* (2011) (58)
LOSS OF INDIVIDUAL ELECTROSTATIC INTERACTIONS BETWEEN AMINOGLYCOSIDE ANTIBIOTICS AND RESISTANCE ENZYMES AS AN EFFECTIVE MEANS TO OVERCOMING BACTERIAL DRUG RESISTANCE (1995) (57)
Bacterial AmpD at the crossroads of peptidoglycan recycling and manifestation of antibiotic resistance. (2009) (56)
An Antibiotic Cloaked by Its Own Resistance Enzyme (1999) (56)
Characterization of the bifunctional aminoglycoside-modifying enzyme ANT(3'')-Ii/AAC(6')-IId from Serratia marcescens. (2006) (55)
Validation of Matrix Metalloproteinase-9 (MMP-9) as a Novel Target for Treatment of Diabetic Foot Ulcers in Humans and Discovery of a Potent and Selective Small-Molecule MMP-9 Inhibitor That Accelerates Healing. (2018) (55)
An antibiotic-resistance enzyme from a deep-sea bacterium. (2010) (54)
Crystal Structures of Bacterial Peptidoglycan Amidase AmpD and an Unprecedented Activation Mechanism* (2011) (54)
Crystal structure of CbpF, a bifunctional choline‐binding protein and autolysis regulator from Streptococcus pneumoniae (2009) (54)
Conformational Dynamics in Penicillin-Binding Protein 2a of Methicillin-Resistant Staphylococcus aureus, Allosteric Communication Network and Enablement of Catalysis. (2017) (53)
A Convenient Triphosgene-Mediated Synthesis of Symmetric Carboxylic Acid Anhydrides (1994) (53)
X-ray Absorption Studies of Human Matrix Metalloproteinase-2 (MMP-2) Bound to a Highly Selective Mechanism-based Inhibitor (2001) (52)
β-Lactam antibiotics, β-lactamases and bacterial resistance (1998) (52)
Discrete steps in sensing of beta-lactam antibiotics by the BlaR1 protein of the methicillin-resistant Staphylococcus aureus bacterium. (2006) (52)
β-Lactam Resistance Mechanisms: Gram-Positive Bacteria and Mycobacterium tuberculosis. (2016) (51)
Synthetic Peptidoglycan Motifs for Germination of Bacterial Spores (2010) (51)
Total synthesis of N-acetylglucosamine-1,6-anhydro-N-acetylmuramylpentapeptide and evaluation of its turnover by AmpD from Escherichia coli. (2009) (51)
Mechanistic characterization of the bifunctional aminoglycoside-modifying enzyme AAC(3)-Ib/AAC(6')-Ib' from Pseudomonas aeruginosa. (2007) (50)
Synthesis of chiral 2-(4-phenoxyphenylsulfonylmethyl)thiiranes as selective gelatinase inhibitors. (2005) (50)
Molecular dynamics at the root of expansion of function in the M69L inhibitor-resistant TEM beta-lactamase from Escherichia coli. (2002) (50)
Roles of Matrix Metalloproteinases in Cutaneous Wound Healing (2016) (50)
X-ray crystal structure of the acylated beta-lactam sensor domain of BlaR1 from Staphylococcus aureus and the mechanism of receptor activation for signal transduction. (2004) (49)
MECHANISM OF TURNOVER OF IMIPENEM BY THE TEM BETA -LACTAMASE REVISITED (1995) (48)
Catalytic mechanism of penicillin-binding protein 5 of Escherichia coli. (2007) (47)
MOLECULAR BASES FOR INTERACTIONS BETWEEN BETA -LACTAM ANTIBIOTICS AND BETA-LACTAMASES (1997) (47)
A Novel β-Lactamase Activity from a Penicillin-binding Protein of Treponema pallidum and Why Syphilis Is Still Treatable with Penicillin* (2004) (46)
Mechanistic Basis for the Action of New Cephalosporin Antibiotics Effective against Methicillin- and Vancomycin-resistant Staphylococcus aureus* (2006) (46)
Reversal of clavulanate resistance conferred by a Ser-244 mutant of TEM-1 beta-lactamase as a result of a second mutation (Arg to Ser at position 164) that enhances activity against ceftazidime (1994) (46)
Cleavage at the stem region releases an active ectodomain of the membrane type 1 matrix metalloproteinase. (2005) (45)
Resolving the Antibiotic Paradox (1998) (45)
X-ray structure of the Asn276Asp variant of the Escherichia coli TEM-1 beta-lactamase: direct observation of electrostatic modulation in resistance to inactivation by clavulanic acid. (1999) (45)
Nuances of Mechanisms and Their Implications for Evolution of the Versatile β-Lactamase Activity: From Biosynthetic Enzymes to Drug Resistance Factors (1997) (44)
The First Structural and Mechanistic Insights for Class D beta-Lactamases: Evidence for a Novel Catalytic Process for Turnover of beta-Lactam Antibiotics (2000) (44)
Synthetic peptidoglycan substrates for penicillin-binding protein 5 of Gram-negative bacteria. (2004) (44)
Reactions of the three AmpD enzymes of Pseudomonas aeruginosa. (2013) (43)
Structural Basis for Potent Slow Binding Inhibition of Human Matrix Metalloproteinase-2 (MMP-2)* (2003) (43)
Lytic transglycosylase MltB of Escherichia coli and its role in recycling of peptidoglycan strands of bacterial cell wall. (2008) (43)
Cell-wall remodeling by the zinc-protease AmpDh3 from Pseudomonas aeruginosa. (2013) (42)
Structure and Cell Wall Cleavage by Modular Lytic Transglycosylase MltC of Escherichia coli (2014) (42)
MECHANISM-BASED INACTIVATION OF BACTERIAL AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASES (1995) (42)
High-resolution crystal structure of MltE, an outer membrane-anchored endolytic peptidoglycan lytic transglycosylase from Escherichia coli. (2011) (42)
Lysine carboxylation in proteins: OXA‐10 β‐lactamase (2005) (42)
Inhibition of the NMC-A β-Lactamase by a Penicillanic Acid Derivative and the Structural Bases for the Increase in Substrate Profile of This Antibiotic Resistance Enzyme (1998) (41)
Testosterone-Induced Matrix Metalloproteinase Activation Is a Checkpoint for Neuronal Addition to the Adult Songbird Brain (2008) (41)
Design, synthesis, and evaluation of a mechanism-based inhibitor for gelatinase A. (2005) (41)
Effects of Asp-179 mutations in TEMpUC19 beta-lactamase on susceptibility to beta-lactams (1995) (41)
Source of Phosphate in the Enzymic Reaction as a Point of Distinction among Aminoglycoside 2″-Phosphotransferases* (2009) (40)
Structural Analysis of the Role of Pseudomonas aeruginosa Penicillin-Binding Protein 5 in β-Lactam Resistance (2013) (40)
Active Site Ring‐Opening of a Thiirane Moiety and Picomolar Inhibition of Gelatinases (2009) (40)
A mechanism-based inhibitor targeting the DD-transpeptidase activity of bacterial penicillin-binding proteins. (2003) (40)
Selective water-soluble gelatinase inhibitor prodrugs. (2011) (39)
Restoration of Susceptibility of Methicillin-resistant Staphylococcus aureus to β-Lactam Antibiotics by Acidic pH (2008) (39)
Interactions of designer antibiotics and the bacterial ribosomal aminoacyl-tRNA site. (2006) (39)
Phosphoryl transfer by aminoglycoside 3'-phosphotransferases and manifestation of antibiotic resistance. (2005) (39)
N-Glycosylation pattern of the zymogenic form of human matrix metalloproteinase-9. (2002) (38)
Mutational Replacement of Leu-293 in the Class C Enterobacter cloacae P99 β-Lactamase Confers Increased MIC of Cefepime (2002) (38)
The bifunctional enzymes of antibiotic resistance. (2009) (38)
Purification, characterization, and investigation of the mechanism of aminoglycoside 3'-phosphotransferase type Ia. (1995) (38)
Strategy in inhibition of cathepsin B, a target in tumor invasion and metastasis. (2004) (37)
Synthesis of a fragment of bacterial cell wall. (2004) (37)
Endless Resistance. Endless Antibiotics? (2016) (37)
From Genome to Proteome to Elucidation of Reactions for All Eleven Known Lytic Transglycosylases from Pseudomonas aeruginosa. (2017) (37)
Metabolism of a Highly Selective Gelatinase Inhibitor Generates Active Metabolite (2007) (37)
Investigation of the mechanism of the cell wall DD-carboxypeptidase reaction of penicillin-binding protein 5 of Escherichia coli by quantum mechanics/molecular mechanics calculations. (2008) (37)
Properties of a Bifunctional Bacterial Antibiotic Resistance Enzyme That Catalyzes ATP-Dependent 2‘‘-Phosphorylation and Acetyl-CoA-Dependent 6‘-Acetylation of Aminoglycosides (1997) (36)
A light-inactivated antibiotic. (2000) (36)
Endogenous matrix metalloproteinases 2 and 9 regulate activation of CD4+ and CD8+ T cells. (2011) (36)
Class C β-Lactamases Operate at the Diffusion Limit for Turnover of Their Preferred Cephalosporin Substrates (1999) (36)
Facilitation of the .DELTA.2 .fwdarw. .DELTA.1 pyrroline tautomerization of carbapenem antibiotics by the highly conserved arginine-244 of class A .beta.-lactamases during the course of turnover (1992) (35)
The oxadiazole antibacterials. (2016) (35)
Muropeptides in Pseudomonas aeruginosa and their Role as Elicitors of β-Lactam-Antibiotic Resistance. (2016) (35)
Glycosylation at Asn211 Regulates the Activation State of the Discoidin Domain Receptor 1 (DDR1)* (2014) (35)
Pronounced Diversity in Electronic and Chemical Properties between the Catalytic Zinc Sites of Tumor Necrosis Factor-α-converting Enzyme and Matrix Metalloproteinases despite Their High Structural Similarity* (2004) (35)
Identification of colchicine in placental blood from patients using herbal medicines. (2001) (35)
Three decades of the class A beta-lactamase acyl-enzyme. (2009) (35)
Design, Synthesis, and Evaluation of a Potent Mechanism-Based Inhibitor for the TEM .beta.-Lactamase with Implications for the Enzyme Mechanism (1995) (35)
Reaction products and the X-ray structure of AmpDh2, a virulence determinant of Pseudomonas aeruginosa. (2013) (34)
Inhibitors for Bacterial Cell-Wall Recycling. (2012) (34)
Constructing and deconstructing the bacterial cell wall (2019) (33)
Three-dimensional QSAR analysis and design of new 1,2,4-oxadiazole antibacterials. (2016) (33)
Conscripting β-Lactamase for Use in Drug Delivery. Synthesis and Biological Activity of a Cephalosporin C10-Ester of an Antibiotic Dipeptide. (1986) (33)
Mechanism-based profiling of MMPs. (2010) (32)
Selective gelatinase inhibitor neuroprotective agents cross the blood-brain barrier. (2012) (32)
Critical hydrogen bonding by serine 235 for cephalosporinase activity of TEM-1 beta-lactamase (1993) (32)
Exploration of the structure-activity relationship of 1,2,4-oxadiazole antibiotics. (2015) (32)
Substrate recognition and catalysis by LytB, a pneumococcal peptidoglycan hydrolase involved in virulence (2015) (32)
Structural and mechanistic aspects of evolution of beta-lactamases and penicillin-binding proteins. (1999) (32)
A Potent Gelatinase Inhibitor with Anti‐Tumor‐Invasive Activity and its Metabolic Disposition (2009) (31)
O-phenyl carbamate and phenyl urea thiiranes as selective matrix metalloproteinase-2 inhibitors that cross the blood-brain barrier. (2013) (31)
A practical synthesis of nitrocefin. (2005) (31)
Catalytic Spectrum of the Penicillin-Binding Protein 4 of Pseudomonas aeruginosa, a Nexus for the Induction of β-Lactam Antibiotic Resistance (2014) (30)
How beta-lactamases have driven pharmaceutical drug discovery. From mechanistic knowledge to clinical circumvention. (1998) (30)
Sulfonate-containing thiiranes as selective gelatinase inhibitors. (2011) (30)
Recognition of aminoglycoside antibiotics by enterococcal-staphylococcal aminoglycoside 3'-phosphotransferase type IIIa: role of substrate amino groups (1996) (30)
Complications from dual roles of sodium hydride as a base and as a reducing agent. (2009) (30)
Fluorinated aminoglycosides and their mechanistic implication for aminoglycoside 3'-phosphotransferases from Gram-negative bacteria. (2004) (29)
Reactions of Escherichia coli TEM beta-lactamase with cephalothin and with C10-dipeptidyl cephalosporin esters. (1986) (29)
The Quinazolinone Allosteric Inhibitor of PBP 2a Synergizes with Piperacillin and Tazobactam against Methicillin-Resistant Staphylococcus aureus (2019) (29)
Thermodynamics of interactions of vancomycin and synthetic surrogates of bacterial cell wall. (2006) (29)
Purification and characterization of aminoglycoside 3'-phosphotransferase type IIa and kinetic comparison with a new mutant enzyme (1994) (29)
Structural basis for progression toward the carbapenemase activity in the GES family of β-lactamases. (2012) (29)
Conformational Transition in the Aminoacyl t‐RNA Site of the Bacterial Ribosome both in the Presence and Absence of an Aminoglycoside Antibiotic (2007) (28)
Lytic transglycosylases LtgA and LtgD perform distinct roles in remodeling, recycling and releasing peptidoglycan in Neisseria gonorrhoeae (2016) (28)
Facile chloride substitution of activated alcohols by triphosgene : application to cephalosporin chemistry (1991) (28)
Phosphorylation of BlaR1 in Manifestation of Antibiotic Resistance in Methicillin-Resistant Staphylococcus aureus and Its Abrogation by Small Molecules. (2015) (28)
Tethered bisubstrate derivatives as probes for mechanism and as inhibitors of aminoglycoside 3'-phosphotransferases. (2000) (28)
β-Lactams against the Fortress of the Gram-Positive Staphylococcus aureus Bacterium. (2020) (28)
Insight into the complex and dynamic process of activation of matrix metalloproteinases. (2001) (28)
Lysine N(zeta)-decarboxylation in the BlaR1 protein from Staphylococcus aureus at the root of its function as an antibiotic sensor. (2007) (28)
Design and characterization of a metalloproteinase inhibitor-tethered resin for the detection of active MMPs in biological samples. (2006) (27)
Dissection of events in the resistance to β-lactam antibiotics mediated by the protein BlaR1 from Staphylococcus aureus. (2012) (26)
Orthologous and Paralogous AmpD Peptidoglycan Amidases from Gram-Negative Bacteria (2016) (26)
Regulation of the Expression of the β-Lactam Antibiotic-Resistance Determinants in Methicillin-Resistant Staphylococcus aureus (MRSA) (2014) (26)
QM/MM Studies of the Matrix Metalloproteinase 2 (MMP2) Inhibition Mechanism of (S)-SB-3CT and its Oxirane Analogue. (2010) (26)
Muropeptide Binding and the X-ray Structure of the Effector Domain of the Transcriptional Regulator AmpR of Pseudomonas aeruginosa. (2017) (25)
Evidence for Structural Elasticity of Class A β-Lactamases in the Course of Catalytic Turnover of the Novel Cephalosporin Cefepime (1996) (25)
A computational evaluation of the mechanism of penicillin-binding protein-catalyzed cross-linking of the bacterial cell wall. (2011) (25)
X-ray Absorption Studies of Human Matrix Metalloproteinase-2 (MMP-2) Bound to a Highly Selective Mechanism-based Inhibitor COMPARISON WITH THE LATENT AND ACTIVE FORMS OF THE ENZYME* (2001) (25)
The external PASTA domain of the essential serine/threonine protein kinase PknB regulates mycobacterial growth (2015) (24)
Synthesis of an inhibitor-tethered resin for detection of active matrix metalloproteinases involved in disease. (2006) (24)
Structure-Activity Relationship for Thiirane-Based Gelatinase Inhibitors. (2012) (24)
The use of neamine as a molecular template: inactivation of bacterial antibiotic resistance enzyme aminoglycoside 3'-phosphotransferase type IIa. (1998) (24)
Structural insight into the binding motifs for the calcium ion and the non-catalytic zinc in matrix metalloproteases. (1998) (24)
DFT studies of the ring-opening mechanism of SB-3CT, a potent inhibitor of matrix metalloproteinase 2. (2009) (24)
Matrix metalloproteinase 2 (MMP2) inhibition: DFT and QM/MM studies of the deprotonation-initialized ring-opening reaction of the sulfoxide analogue of SB-3CT. (2010) (24)
Shared functional attributes between the mecA gene product of Staphylococcus sciuri and penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus. (2007) (24)
PENEM BRL 42715 : AN EFFECTIVE INACTIVATOR FOR BETA -LACTAMASES (1995) (24)
The Tipper-Strominger Hypothesis and Triggering of Allostery in Penicillin-Binding Protein 2a of Methicillin-Resistant Staphylococcus aureus (MRSA). (2015) (24)
Activation by Allostery in Cell-Wall Remodeling by a Modular Membrane-Bound Lytic Transglycosylase from Pseudomonas aeruginosa. (2016) (23)
Whole-Genome Shotgun Sequencing of Two β-Proteobacterial Species in Search of the Bulgecin Biosynthetic Cluster (2017) (23)
Resistance to the third-generation cephalosporin ceftazidime by a deacylation-deficient mutant of the TEM β-lactamase by the uncommon covalent-trapping mechanism. (2011) (23)
Lysine Nζ-Decarboxylation Switch and Activation of the β-Lactam Sensor Domain of BlaR1 Protein of Methicillin-resistant Staphylococcus aureus* (2011) (23)
Allostery, Recognition of Nascent Peptidoglycan, and Cross-linking of the Cell Wall by the Essential Penicillin-Binding Protein 2x of Streptococcus pneumoniae. (2018) (23)
Characterization of the β-Lactam Antibiotic Sensor Domain of the MecR1 Signal Sensor/Transducer Protein from Methicillin-Resistant Staphylococcus aureus† (2007) (23)
Purification of recombinant pp60v-src protein tyrosine kinase and phosphorylation of peptides with different secondary structure preference. (1989) (23)
Amidase Activity of AmiC Controls Cell Separation and Stem Peptide Release and Is Enhanced by NlpD in Neisseria gonorrhoeae* (2016) (23)
Inactivation of alanine racemase by beta-chloro-L-alanine released enzymatically from amino acid and peptide C10-esters of deacetylcephalothin. (1987) (22)
Kinetic mechanism of enterococcal aminoglycoside phosphotransferase 2"-Ib. (2007) (22)
A new approach to the preparation of N-carboxy .alpha.-amino acid anhydrides (1985) (22)
Exolytic and endolytic turnover of peptidoglycan by lytic transglycosylase Slt of Pseudomonas aeruginosa (2018) (22)
β-Lactam Antibiotics (2010) (22)
Total Syntheses of Bulgecins A, B, and C and Their Bactericidal Potentiation of the β-Lactam Antibiotics (2018) (22)
Potent mechanism-based inhibition of the TEM-1 .beta.-lactamase by novel N-sulfonyloxy .beta.-lactams (1995) (22)
A dynamic structure for the acyl-enzyme species of the antibiotic aztreonam with the Citrobacter freundii beta-lactamase revealed by infrared spectroscopy and molecular dynamics simulations. (2003) (22)
Identification of Products of Inhibition of GES-2 β-Lactamase by Tazobactam by X-ray Crystallography and Spectrometry* (2011) (22)
The Cell Shape-determining Csd6 Protein from Helicobacter pylori Constitutes a New Family of l,d-Carboxypeptidase* (2015) (22)
Structural Insights into the Catalytic Domains of Human Matrix Metalloprotease-2 and Human Matrix Metalloprotease-9: Implications for Substrate Specificities (1997) (21)
Characterization of the Dimerization Interface of Membrane Type 4 (MT4)-Matrix Metalloproteinase* (2011) (21)
Investigation of signal transduction routes within the sensor/transducer protein BlaR1 of Staphylococcus aureus. (2015) (21)
Identification and Role of the Homodimerization Interface of the Glycosylphosphatidylinositol-anchored Membrane Type 6 Matrix Metalloproteinase (MMP25)* (2008) (21)
A Type VI secretion system delivers a cell-wall amidase to target bacterial competitors. (2020) (21)
Structural basis of denuded glycan recognition by SPOR domains in bacterial cell division (2019) (20)
Hydrolysis of ATP by Aminoglycoside 3′-Phosphotransferases (2006) (20)
Slt, MltD, and MltG of Pseudomonas aeruginosa as Targets of Bulgecin A in Potentiation of β-Lactam Antibiotics. (2019) (20)
Preparation of ceph-3-em esters unaccompanied by .DELTA.3 .fwdarw. .DELTA.2 isomerization of the cephalosporin (1986) (20)
1H-NMR analysis of copper-aminoglycoside complexes in solution and its implication for regioselective modification of multifunctional aminoglycoside antibiotics (1998) (20)
Exploration of the Structural Space in 4(3H)-Quinazolinone Antibacterials. (2020) (20)
Catalytic Cycle of the N-Acetylglucosaminidase NagZ from Pseudomonas aeruginosa. (2017) (20)
N-Sulfonyloxy-β-lactam Inhibitors for β-Lactamases (2000) (19)
Mechanism of the Escherichia coli MltE lytic transglycosylase, the cell-wall-penetrating enzyme for Type VI secretion system assembly (2018) (19)
Transferase Versus Hydrolase: The Role of Conformational Flexibility in Reaction Specificity. (2017) (19)
Conscripting the Active-Site Zinc Ion in Carboxypeptidase A in Inactivation Chemistry by a New Type of Irreversible Enzyme Inactivator (1994) (19)
Bacterial Antibiotic Resistance (2003) (19)
Inhibition of the Broad Spectrum Nonmetallocarbapenamase of Class A (NMC-A) β-Lactamase from Enterobacter cloacae by Monocyclic β-Lactams* 210 (1999) (18)
A convenient synthesis of a selective gelatinase inhibitor as an antimetastatic agent. (2004) (18)
In Vitro and In Vivo Synergy of the Oxadiazole Class of Antibacterials with β-Lactams (2016) (18)
Structure of Csd3 from Helicobacter pylori, a cell shape-determining metallopeptidase (2015) (18)
Design and synthesis of a structurally constrained aminoglycoside. (2007) (18)
6-(Hydroxyalkyl)penicillanates as Probes for Mechanisms of β-Lactamases (2000) (17)
Why clinically used tazobactam and sulbactam are poor inhibitors of OXA-10 beta-lactamase: Raman crystallographic evidence. (2008) (17)
The Allosteric Site for the Nascent Cell Wall in Penicillin-Binding Protein 2a: An Achilles' Heel of Methicillin-Resistant Staphylococcus aureus. (2015) (17)
Early Abrogation of Gelatinase Activity Extends the Time Window for tPA Thrombolysis after Embolic Focal Cerebral Ischemia in Mice (2018) (17)
Structural Basis of the Heterodimer Formation between Cell Shape-Determining Proteins Csd1 and Csd2 from Helicobacter pylori (2016) (17)
Identification of amino acid residues involved in substrate recognition by the catalytic subunit of bovine cyclic AMP dependent protein kinase: peptide-based affinity labels. (1988) (17)
Host-guest chemistry of the peptidoglycan. (2010) (16)
Binding of the gene repressor BlaI to the bla operon in methicillin-resistant Staphylococcus aureus. (2010) (16)
Structural basis for the recognition of muramyltripeptide by Helicobacter pylori Csd4, a d,l-carboxypeptidase controlling the helical cell shape (2014) (16)
Water-Soluble MMP-9 Inhibitor Reduces Lesion Volume after Severe Traumatic Brain Injury. (2015) (16)
The crystal structure of the major pneumococcal autolysin LytA in complex with a large peptidoglycan fragment reveals the pivotal role of glycans for lytic activity (2016) (16)
Crystallographic and computational insight on the mechanism of zinc-ion-dependent inactivation of carboxypeptidase a by 2-benzyl-3-iodopropanoate. (1996) (15)
Computational investigation of irreversible inactivation of the zinc-dependent protease carboxypeptidase A. (2005) (15)
Aminoglycoside Antibiotics: Structures and Mechanisms of Action (2001) (14)
Selection and characterization of beta-lactam-beta-lactamase inactivator-resistant mutants following PCR mutagenesis of the TEM-1 beta-lactamase gene. (1998) (14)
Mechanistic and clinical aspects of beta-lactam antibiotics and beta-lactamases. (1999) (14)
Metabolism of (4‐Phenoxyphenylsulfonyl)methylthiirane, a Selective Gelatinase Inhibitor (2008) (14)
Revealing cell-surface intramolecular interactions in the BlaR1 protein of methicillin-resistant Staphylococcus aureus by NMR spectroscopy. (2014) (14)
Synthesis, Kinetic Characterization and Metabolism of Diastereomeric 2‐(1‐(4‐Phenoxyphenylsulfonyl)ethyl)thiiranes as Potent Gelatinase and MT1‐MMP Inhibitors (2009) (14)
Use of silver carbonate in the Wittig reaction. (2013) (14)
From genes to sequences to antibiotics: prospects for future developments from microbial genomics. (2000) (14)
AAC(3)-XI, a New Aminoglycoside 3-N-Acetyltransferase from Corynebacterium striatum (2015) (14)
An Amino Acid Position at Crossroads of Evolution of Protein Function (2012) (13)
Regioselective Control of the SNAr Amination of 5-Substituted-2,4-Dichloropyrimidines Using Tertiary Amine Nucleophiles. (2015) (13)
Turnover of Bacterial Cell Wall by SltB3, a Multidomain Lytic Transglycosylase of Pseudomonas aeruginosa. (2016) (13)
N-(tert-Butoxycarbonyloxy)-5-norbornene-endo-2,3-dicarboximide, a Reagent for the Regioselective Introduction of the tert-Butoxycarbonyl (BOC) Protective Group at Unhindered Amines: Application to Amino glycoside Chemistry (1994) (13)
Conjoint molecules of cephalosporins and aminoglycosides (2001) (13)
Aminoglycoside 2″-Phosphotransferase Type IIIa from Enterococcus* (2008) (13)
Potentiation of the activity of β-lactam antibiotics by farnesol and its derivatives. (2018) (12)
Peptidoglycan reshaping by a noncanonical peptidase for helical cell shape in Campylobacter jejuni (2020) (12)
The first mechanism-based inactivators for angiotensin-converting enzyme. (1992) (12)
Mutational and Structural Analyses of the Hinge Region of Membrane Type 1-Matrix Metalloproteinase and Enzyme Processing* (2005) (12)
Structure-Activity Relationship for the Oxadiazole Class of Antibacterials. (2019) (12)
The Basis for Resistance to b -Lactam Antibiotics by Penicillin-Binding Protein 2a (PBP2a) of Methicillin-Resistant Staphylococcus aureus (2004) (12)
Mechanism-based inhibition of zinc proteases. (2001) (12)
MT1-MMP shedding involves an ADAM and is independent of its localization in lipid rafts. (2006) (12)
Quantification of the extent of attenuation of the rate of turnover chemistry of the TEM-1 β-lactamase by the α-1R-hydroxyethyl group in substrates (1996) (12)
Selective Inhibition of MMP-2 Does Not Alter Neurological Recovery after Spinal Cord Injury. (2016) (12)
Design of an effective mechanism-based inactivator for a zinc protease. (1990) (12)
Elucidation of the structure of the membrane anchor of penicillin-binding protein 5 of Escherichia coli. (2010) (11)
Targeting renal dipeptidase (dehydropeptidase I) for inactivation by mechanism-based inactivators. (1991) (11)
13 Bacterial Cell Wall Morphology and Biochemistry (2009) (11)
Regiospecific syntheses of 6alpha-(1R-Hydroxyoctyl)penicillanic acid and 6beta-(1R-hydroxyoctyl)penicillanic acid as mechanistic probes of class D beta-lactamases. (2009) (11)
Sulfonylation-induced N- to O-acetyl migration in 2-acetamidoethanol derivatives. (2010) (11)
Metabolism of (4-phenoxyphenylsulfonyl) methylthiirane, a selective gelatinase inhibitor. (2008) (11)
Transition State Stabilization (2002) (10)
Expression of active matrix metalloproteinase‐9 as a likely contributor to the clinical failure of aclerastide in treatment of diabetic foot ulcers (2018) (10)
The future of the b-lactams (2010) (10)
Conformational analyses of thiirane-based gelatinase inhibitors. (2008) (10)
8.13 – Enzymology of Bacterial Resistance (2010) (10)
Selective MMP-9 Inhibitor (R)-ND-336 Alone or in Combination with Linezolid Accelerates Wound Healing in Infected Diabetic Mice. (2020) (10)
Synthesis and NMR characterization of (Z,Z,Z,Z,E,E,ω)-heptaprenol. (2012) (10)
Unconventional Antibacterials and Adjuvants. (2021) (10)
Peptidic mechanism-based inactivators for carboxypeptidase A. (1991) (10)
Strategies to Counter Resistance Mechanisms of Action and Resistance and Aminoglycosides : Perspectives on (2000) (10)
Are matrix metalloproteinases relevant therapeutic targets for prostate cancer bone metastasis? (2008) (10)
The X‐Ray Structure of Carboxypeptidase A Inhibited by a Thiirane Mechanism‐Based Inhibitor (2010) (10)
Mutations in mmpL and in the Cell Wall Stress Stimulon Contribute to Resistance to Oxadiazole Antibiotics in Methicillin-Resistant Staphylococcus aureus (2014) (9)
MMP-9 inhibitors impair learning in spontaneously hypertensive rats (2018) (9)
Turnover of Bacterial Cell Wall by SltB3, a Multidomain Lytic Transglycosylase of Pseudomonas aeruginosa. (2016) (9)
Catalytic Cycle of Glycoside Hydrolase BglX from Pseudomonas aeruginosa and Its Implication in Biofilm Formation. (2019) (9)
Lysine carboxylation in proteins: OXA-10 beta-lactamase. (2005) (9)
The Use of Triphosgene in Preparation of N-Carboxy-α-amino Acid Anhydrides. (1992) (9)
Insights into the three-dimensional structure of crotalase: Implications for biological activity and substrate specificity (1997) (9)
High-resolution X-ray structure of an acyl-enzyme species for the class D OXA-10 beta-lactamase. (2002) (9)
Protonation states of active‐site lysines of penicillin‐binding protein 6 from Escherichia coli and the mechanistic implications (2014) (9)
Allosteric Inhibition of Bacterial Targets: An Opportunity for Discovery of Novel Antibacterial Classes (2017) (8)
Stereoselective reduction of alpha-bromopenicillanates by tributylphosphine. (2000) (8)
Cinnamonitrile Adjuvants Restore Susceptibility to β-Lactams against Methicillin-Resistant Staphylococcus aureus. (2019) (8)
Crystallization and preliminary X-ray diffraction analysis of the lytic transglycosylase MltE from Escherichia coli. (2011) (8)
The Natural Product Essramycin and Three of Its Isomers Are Devoid of Antibacterial Activity. (2016) (8)
Exploring the functional space of thiiranes as gelatinase inhibitors using click chemistry. (2011) (8)
Molecular Bases for Interactions Between β‐Lactam Antibiotics and β‐Lactamases (1997) (8)
b -Lactam Resistance Mechanisms: Gram-Positive Bacteria and Mycobacterium tuberculosis (2016) (8)
Characterization of a selective inhibitor for matrix metalloproteinase-8 (MMP-8) (2014) (8)
Hyperbaric oxygen therapy accelerates wound healing in diabetic mice by decreasing active matrix metalloproteinase‐9 (2019) (8)
A novel approach to deacylation of ceph-3-em esters (1986) (8)
Resistance to beta-Lactam Antibiotics Mediated by beta-Lactamases: Structure, Mechanism, and Evolution (2007) (7)
Methodologies in Syntheses of Aminoglycoside Antibiotics (2001) (7)
Activities of Oxadiazole Antibacterials against Staphylococcus aureus and Other Gram-Positive Bacteria (2018) (7)
Chapter 3:The β-Lactam (Azetidin-2-one) as a Privileged Ring in Medicinal Chemistry (2015) (7)
X-ray Structure of Catenated Lytic Transglycosylase SltB1. (2017) (7)
Evaluation of inhibition of the carbenicillin‐hydrolyzing β‐lactamase PSE‐4 by the clinically used mechanism‐based inhibitors (2000) (7)
Discovery of Mechanism-Based Inactivators for Human Pancreatic Carboxypeptidase A from a Focused Synthetic Library. (2017) (7)
Cytoplasmic-Membrane Anchoring of a Class A β-Lactamase and Its Capacity in Manifesting Antibiotic Resistance (2007) (7)
Templates for design of inhibitors for serine proteases: application of the program DOCK to the discovery of novel inhibitors for thrombin. (1998) (7)
Nanomolecular and Supramolecular Paths toward Peptidoglycan Structure (2006) (6)
Reactions of All E . coli Lytic Transglycosylases with Bacterial Cell (2013) (6)
Deciphering the Nature of Enzymatic Modifications of Bacterial Cell Walls (2017) (6)
HYDROLYSIS OF ATP BY AMINOGLYCOSIDE 3’- PHOSPHOTRANSFERASES: AN UNEXPECTED COST TO BACTERIA FOR HARBORING AN ANTIBIOTIC RESISTANCE ENZYME (2005) (6)
Characterization of the beta-lactam antibiotic sensor domain of the MecR1 signal sensor/transducer protein from methicillin-resistant Staphylococcus aureus. (2007) (6)
Crystal structure of CbpF, a bifunctional choline‐binding protein and autolysis regulator from Streptococcus pneumoniae (2009) (5)
A mechanism-based inactivation study of neutral endopeptidase 24.11. (1993) (5)
Monitoring beta-lactamase activity in vivo by 13C nuclear magnetic resonance spectroscopy (1988) (5)
Preparation of Ceph-3-em Esters Unaccompanied by δ3 → δ2 Isomerization of the Cephalosporin. (1987) (5)
Corrigendum: Muropeptides in Pseudomonas aeruginosa and their Role as Elicitors of β-Lactam-Antibiotic Resistance. (2016) (5)
Faculty Opinions recommendation of Ultra-large library docking for discovering new chemotypes. (2019) (5)
Exploitation of Conformational Dynamics in Imparting Selective Inhibition for Related Matrix Metalloproteinases. (2017) (5)
Inhibition of β-Lactamases by 6,6-Bis(hydroxylmethyl)penicillanate (2001) (5)
Hydrogen Bonding and Attenuation of the Rate of Enzymic Catalysis (1998) (4)
Inactivation of the catalytic subunit of bovine cAMP‐dependent protein kinase by a peptide‐based affinity inactivator (1990) (4)
Discovery of a potent picolinamide antibacterial active against Clostridioides difficile. (2020) (4)
Selection and Characterization of b-Lactam – b-Lactamase Inactivator-Resistant Mutants following PCR Mutagenesis of the TEM-1 b-Lactamase Gene (1998) (4)
A Structural Dissection of the Active Site of the Lytic Transglycosylase MltE from Escherichia coli. (2018) (4)
Antibiotics as physiological stress inducers and bacterial response to the challenge. (2012) (4)
The β-Lactam Antibiotics: Their Future in the Face of Resistance (2014) (4)
Properties of analogues of an intermediate in the process of mechanism-based inactivation of carboxypeptidase A. (1996) (4)
B -lactamases And Resistance To B-lactam Antibiotics (2001) (4)
Bacterial Cell Wall (2015) (4)
Evidence for a new enzyme-catalyzed reaction other than .beta.-lactam hydrolysis in turnover of a penem by the TEM-1 .beta.-lactamase (1993) (4)
Horizontal-Acquisition of a Promiscuous Peptidoglycan-Recycling Enzyme Enables Aphids To Influence Symbiont Cell Wall Metabolism (2021) (3)
Susceptibility of Methicillin-Resistant Staphylococcus aureus to Five Quinazolinone Antibacterials (2019) (3)
Bacterial Cell Wall: Morphology and Biochemistry (3)
MMP-1 and ADAM10 as Targets for Therapeutic Intervention in Idiopathic Pulmonary Fibrosis. (2022) (3)
Facile Chloride Substitution of Activated Alcohols by Triphosgene: Application to Cephalosporin Chemistry. (1992) (3)
Prospects of therapies targeting resistant bacteria-New challenges 20 years post emergence of vancomycin-resistant enterococcus. (2007) (3)
Production of Proteins of the SARS-CoV-2 Proteome for Drug Discovery (2021) (3)
Mechanistic support for the stepwise process for inactivation of class A β-lactamases by clavulanate (1995) (3)
Synthesis and shift-reagent-assisted full NMR assignment of bacterial (Z8,E2,ω)-undecaprenol. (2017) (3)
In Search of Selectivity in Inhibition of ADAM10. (2018) (3)
The use of neamine as a molecular template: identification of active site residues in the bacterial antibiotic resistance enzyme aminoglycoside 3'-phosphotransferase type IIa by mass spectroscopy. (1998) (3)
Crystal Structure of an Outer Membrane-Anchored Endolytic Peptidoglycan Lytic Transglycosylase (MltE) from Escherichia coli (2011) (3)
Fluorescence Assessment of the AmpR-Signaling Network of Pseudomonas aeruginosa to Exposure to β-Lactam Antibiotics. (2020) (3)
An Atypical ABC Transporter Is Involved in Antifungal Resistance and Host Interactions in the Pathogenic Fungus Cryptococcus neoformans (2022) (3)
Structure-activity relationship of the cinnamamide family of antibiotic potentiators for methicillin-resistant Staphylococcus aureus (MRSA). (2018) (3)
A Convenient Triphosgene‐Mediated Synthesis of Symmetric Carboxylic Acid Anhydrides. (1994) (3)
Chapter 10:Thiirane Class of Gelatinase Inhibitors as a Privileged Template that Crosses the Blood–Brain Barrier (2015) (2)
Crystal Structures of Bacterial (2011) (2)
A NEW APPROACH TO THE PREPARATION OF N-CARBOXY α-AMINO ACID ANHYDRIDES (1985) (2)
Facile preparation of a highly functionalized tetrahydropyran by catalytic hydrogenation of an oxazoline. (2008) (2)
Integrative structural biology of the penicillin-binding protein-1 from Staphylococcus aureus, an essential component of the divisome machinery (2021) (2)
Insertion of Epicatechin Gallate into the Cytoplasmic Membrane of Methicillin-resistantStaphylococcus aureus Disrupts Penicillin-binding Protein (PBP) 2a-mediated (2010) (2)
Faculty Opinions recommendation of Total synthesis of Escherichia coli with a recoded genome. (2019) (2)
Key side products due to reactivity of dimethylmaleoyl moiety as amine protective group (2009) (2)
6-(Hydroxyalkyl)penicillanates as Probes for Mechanisms of β-Lactamases. (2001) (2)
Synthetic Efforts in Preparations of Components of the Bacterial Cell Wall (2008) (2)
Side reaction of significance in preparation of peptide- or peptidomimetic-based hydroxamate enzyme inhibitors. (2006) (2)
Exploration of mild copper-mediated coupling of organotrifluoroborates in the synthesis of thiirane-based inhibitors of matrix metalloproteinases. (2011) (2)
Binding of Antibiotics to the Aminoacyl-Trna Site of Bacterial Ribosome (2007) (2)
Inhibition of Class A β-Lactamases (2007) (2)
Methoxycarbonylsulfamoyl)triethylammonium Hydroxide (2008) (2)
Matrix Metalloproteinase 2 ( MMP 2 ) Inhibition : DFT and QM / MM Studies of the Deprotonation-Initialized Ring-Opening Reaction of the Sulfoxide Analogue of SB-3 CT (2010) (2)
Medicinal Chemistry of β‐Lactam Antibiotics (2021) (2)
Crystal structure of Penicillin-Binding Protein 6 (PBP6) from E. coli in apo state (2009) (1)
Inhibition of human prostate cancer growth and osteolysis in a bone metastasis model by a mechanism-based specific gelatinase inhibitor (SB-3CT) (2005) (1)
1 Substrate Hydrolysis by Matrix Metalloproteinase-9 (2001) (1)
Structural and Mechanistic Aspects of Evolution of β-Lactamases and Penicillin-Binding Proteins (1999) (1)
Structure-based inhibitor design for reshaping bacterial morphology (2022) (1)
Bis(trichloromethyl) Carbonate (2006) (1)
Complex biological processes and their central chemical events. (2003) (1)
Pharmacological Stabilization of Intracranial Aneurysms in Mice (2012) (1)
Inhibition of MMP-9 by a selective gelatinase inhibitor protects neurovasculature from embolic focal cerebral ischemia (2012) (1)
Matrix Metalloproteinase-14 as an Instigator of Fibrosis in Human Pterygium and Its Pharmacological Intervention. (2022) (1)
Turnover Chemistry and Structural Characterization of the Cj0843c Lytic Transglycosylase of Campylobacter jejuni. (2021) (1)
6-(hydroxyalkyl)penicillanates as probes for mechanisms of beta-lactamases. (2000) (1)
Strategies for Circumventing Bacterial Resistance Mechanisms (2014) (1)
Structural basis of the Escherichi coli outer-membrane permeability (1999) (1)
The Use of Neamine as a Molecular Template: Inactivation of Bacterial Antibiotic Resistance Enzyme Aminoglycoside 3′-Phosphotransferase Type IIa. (1999) (1)
OXA 10 class D beta-lactamase at pH 6.0 (2001) (1)
Proteomics Identification of Targets for Intervention in Pressure Ulcers. (2022) (1)
N-(tert-Butoxycarbonyloxy)-5-norbornene-endo-2,3-dicarboximide, a Reagent for the Regioselective Introduction of the tert-Butoxycarbonyl (BOC) Protective Group at Unhindered Amines: Application to Aminoglycoside Chemistry. (2010) (1)
Enantiomers of a selective gelatinase inhibitor: (R)- and (S)-2-[(4-phenoxyphenyl)sulfonylmethyl]thiirane. (2014) (1)
A rational approach for the design of mechanism-based inactivators for zinc proteases (1994) (1)
Denitrogenation of shale oil by oxime formation from pyrroles (1998) (1)
A positive positive to negative (2018) (1)
1-(t-Butoxycarbonyl)imidazole (2001) (1)
Metabolism of the Selective Matrix Metalloproteinase-9 Inhibitor (R)-ND-336. (2021) (1)
Antibacterials: Volume II (2018) (1)
Sulfonylation‐Induced N‐ to O‐Acetyl Migration in 2‐Acetamidoethanol Derivatives. (2010) (1)
A Renaissance of Interest in Amino Glycoside Antibiotics (2001) (1)
Crystal structure of Penicillin-Binding Protein 6 (PBP6) from E. coli in complex with a substrate fragment (2009) (0)
Meropenem acylated BlaR1 sensor domain from Staphylococcus aureus (2011) (0)
Faculty Opinions recommendation of Mechanistic Insights into β-Lactamase-Catalysed Carbapenem Degradation Through Product Characterisation. (2020) (0)
Synthesis of Muramyl-δ-Lactam in Spore Peptidoglycan of Clostridioides difficile. (2023) (0)
A-site RNA in complex with neamine (2006) (0)
Faculty Opinions recommendation of From coarse to fine: the absolute Escherichia coli proteome under diverse growth conditions. (2021) (0)
Faculty Opinions recommendation of Microplate-based surface area assay for rapid phenotypic antibiotic susceptibility testing. (2019) (0)
CRYSTAL STRUCTURE OF CHOLINE BINDING PROTEIN F FROM STREPTOCOCCUS PNEUMONIAE IN THE PRESENCE OF A PEPTIDOGLYCAN ANALOGUE (TETRASACCHARIDE-PENTAPEPTIDE) (2009) (0)
High-resolution crystal structure of an outer membrane-anchored endolytic peptidoglycan lytic transglycosylase (MltE) fromEscherichia coli (2011) (0)
Synthetic Strategies for Regioselective Structural Modifications of Multifunctional Amino Glycoside Antibiotics (1999) (0)
Penetration through Outer Membrane and Efflux Potential in Pseudomonas aeruginosa of Bulgecin A as an Adjuvant to β-Lactam Antibiotics (2023) (0)
Crystal structure of TEM-76 beta-lactamase at 1.4 Angstrom resolution (2005) (0)
OXA-10 class D beta-lactamase partially acylated with reacted 6beta-(1-hydroxy-1-methylethyl) penicillanic acid (2001) (0)
Penicillin-Binding Protein 5 of Escherichia coli (2013) (0)
Mechanism of the Escherichia coli MltE lytic transglycosylase, the cell-wall-penetrating enzyme for Type VI secretion system assembly (2018) (0)
OXA 10 class D beta-lactamase at pH 6.5 (2001) (0)
MAD structure of OXA10 class D beta-lactamase (2001) (0)
Erratum (1974) (0)
Crystal structure of NagZ from Pseudomonas aeruginosa in complex with N-acetylglucosamine (2017) (0)
β-Lactams from the Ocean (2023) (0)
Faculty Opinions recommendation of Promysalin Elicits Species-Selective Inhibition of Pseudomonas aeruginosa by Targeting Succinate Dehydrogenase. (2018) (0)
Crystal structure of AmpDh2 from Pseudomonas aeruginosa in complex with pentapeptide (2013) (0)
Faculty Opinions recommendation of Genetically Encoded Quinone Methides Enabling Rapid, Site-Specific, and Photocontrolled Protein Modification with Amine Reagents. (2021) (0)
Structure of a Penicillin Binding Protein Complexed with a Cephalosporin-Peptidoglycan Mimic (2002) (0)
Faculty Opinions recommendation of Implementation of permeation rules leads to a FabI inhibitor with activity against Gram-negative pathogens. (2020) (0)
CRYSTAL STRUCTURE OF THE IMIPENEM INHIBITED TEM-1 BETA-LACTAMASE FROM ESCHERICHIA COLI (1999) (0)
Faculty Opinions recommendation of A broad-spectrum antibiotic adjuvant reverses multidrug-resistant Gram-negative pathogens. (2020) (0)
Collagen-mediated Signaling Receptor Tyrosine Kinases in Discoidin Domain Receptors : Unique Minireviews : (2013) (0)
Matrix metalloproteinase proteolysis after stroke : a surrogate indicator for early diagnosis and validation of treatment (2010) (0)
1‐N‐(t‐Butoxycarbonyl)‐1H‐benzotriazole 3‐N‐Oxide (2001) (0)
A mechanism-based inactivation study of neutral endopeptidase 24.11. [Erratum to document cited in CA119(13):134114z] (1993) (0)
crystal structure of AmpD holoenzyme (2011) (0)
Regioselective Control of the SNAr Amination of 5‐Substituted‐2,4‐dichloropyrimidines Using Tertiary Amine Nucleophiles. (2015) (0)
Faculty Opinions recommendation of A Staphylococcus pro-apoptotic peptide induces acute exacerbation of pulmonary fibrosis. (2020) (0)
crystal structure of AmpD in complex with reaction products (2011) (0)
Crystal structure of AmpDh2 from Pseudomonas aeruginosa in complex with NAG-NAM-NAG-NAM tetrasaccharide (2013) (0)
Faculty Opinions recommendation of Bio-Orthogonal Chemistry and Reloadable Biomaterial Enable Local Activation of Antibiotic Prodrugs and Enhance Treatments against Staphylococcus aureus Infections. (2019) (0)
Faculty Opinions recommendation of Engineering bromodomains with a photoactive amino acid by engaging 'Privileged' tRNA synthetases. (2021) (0)
A Novel Approach to Deacylation of Ceph-3-em Esters. (1986) (0)
Crystal structure of NagZ H174A mutant from Pseudomonas aeruginosa (2017) (0)
Matrix metalloproteinase inhibitors (2001) (0)
CBAP-acylated BlaR1 sensor domain from Staphylococcus aureus (2011) (0)
Resistance -Lactam β Penicillin-Binding Protein 5 in Pseudomonas aeruginosa Structural Analysis of the Role of (2014) (0)
Stereoselective Reduction of α‐Bromopenicillanates by Tributylphosphine. (2001) (0)
New Antibiotics For The Post‐Antibiotic Era (2016) (0)
Erratum: A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia (Journal of Neuroscience (July 6, 2005) (6401-6408)) (2005) (0)
Aminoglycoside 2 Reaction as a Point of Distinction among Source of Phosphate in the Enzymic Enzyme Catalysis and Regulation (2009) (0)
Novel and Selective Inactivators for Matrix Metalloproteases Involved in Breast Cancer Metastasis (1998) (0)
Turnover chemistry and structural characterization of the Cj0843c lytic transglycosylase of Campylobacter jejuni (2021) (0)
Crystal structure of Zn-containing NagZ H174A mutant from Pseudomonas aeruginosa (2017) (0)
Crystal structure of NagZ from Pseudomonas aeruginosa in complex with N-acetylglucosamine and L-Ala-1,6-anhydroMurNAc (2017) (0)
Turapov 2015 supplemental material figures revised (2015) (0)
Crystal structure of NagZ from Pseudomonas aeruginosa (2017) (0)
Structural basis of the peptidoglycan binding to LytA, the major pneumococcal autolysin (2015) (0)
Crystal structure of NagZ H174A mutant from Pseudomonas aeruginosa in complex with the inhibitor 2-acetamido-1,2-dideoxynojirimycin (2017) (0)
Structure of Helicobacter pylori Csd3 from the hexagonal crystal (2015) (0)
Monitoring 1-Lactamase Activity In Vivo by 13C Nuclear Magnetic Resonance Spectroscopy (0)
Structure of OXA10 beta-lactamase at pH 8.3 (2001) (0)
Asite RNA + designer antibiotic (2006) (0)
Inhibition of beta-lactamases by 6,6-bis(hydroxylmethyl)penicillanate. (2001) (0)
1‐t‐Butoxycarbonyl‐1,2,4‐triazole (2001) (0)
Crystal structure of Penicillin-Binding Protein 6 (PBP6) from E. coli in acyl-enzyme complex with ampicillin (2009) (0)
Extracellular Proteases as Targets for Treatment of Cancer Metatases (2005) (0)
The Type VI Secretion System of Pseudomonas aeruginosa Delivers a Cell-Wall Amidase to Target Bacterial Competitors (2019) (0)
Beta-Lactam-Sensor Domain of BlaR1 (Apo) from Staphylococcus Aureus with Carboxylated Lys392 (2011) (0)
Molecular Mechanism of Peptidoglycan Recognition by OmpA in Gram-negative Bacteria (2012) (0)
AD Award Number : DAMD 1797-1-7174 TITLE : Novel and Selective Inactivators for Matrix . Metalloproteases Involved in Breast Cancer Metastasis (0)
Faculty Opinions recommendation of Specific fluorescence labeling of target proteins by using a ligand-4-azidophthalimide conjugate. (2018) (0)
Faculty Opinions recommendation of Vancomycin-Arginine Conjugate Inhibits Growth of Carbapenem-Resistant E. coli and Targets Cell-Wall Synthesis. (2020) (0)
Antibacterials: Volume I (2018) (0)
6ALPHA-(HYDROXYPROPYL)PENICILLANATE ACYLATED ON NMC-A BETA-LACTAMASE FROM ENTEROBACTER CLOACAE (1998) (0)
Faculty Opinions recommendation of Structural and mechanistic analysis of a β-glycoside phosphorylase identified by screening a metagenomic library. (2018) (0)
Glyoxylyl Chloride p‐Toluenesulfonylhydrazone (2009) (0)
Monitoring β-Lactamase Activity In Vivo by 13C Nuclear Magnetic Resonance Spectroscopy (1988) (0)
Application of 2D-ITC to the Elucidation of the Enzymatic Mechanism of N-Acetylmuramic Acid/N-Acetylglucosamine Kinase (AmgK) from Pseudomonas aeruginosa. (2023) (0)
CRYSTAL STRUCTURE OF STREPTOMYCES R61 DD-PEPTIDASE COMPLEXED WITH A NOVEL CEPHALOSPORIN ANALOG OF CELL WALL PEPTIDOGLYCAN (2001) (0)
Structural analysis of the tripeptide-bound form of Helicobacter pylori Csd4, a D,L-carboxypeptidase (2014) (0)
In vitro studies of the protein-interaction network of cell-wall lytic transglycosylase RlpA of Pseudomonas aeruginosa (2022) (0)
30S ribosome + designer antibiotic (2006) (0)
aureusstant Staphylococcus to Oxadiazole Antibiotics in Stress Stimulon Contribute to Resistance and in the Cell Wall mmpL Mutations in (2014) (0)
Structure of Lytic Transglycosylase MltC from Escherichia coli in complex with tetrasaccharide at 2.9 A resolution. (2014) (0)
Synthetic Efforts in Preparation of Components of the Bacterial Cell Wall (2009) (0)
OXA 10 class D beta-lactamase at pH 7.5 (2001) (0)
crystal structure of Se-Met AmpD derivative (2011) (0)
715. Bulgecin A lowers Imipenem MICs in Clinical MDR Acinetobacter baumannii (ACB) Strains (2019) (0)
Erratum to “The sentinel role of peptidoglycan recycling in the β-lactam resistance of the Gram-negative Enterobacteriaceae and Pseudomonas aeruginosa” [Bioorg. Chem. 56C (2014) 41–48] (2014) (0)
Mechanism-based Inhibitor of Matrix Metalloproteinase-9 Rescues Brain from Focal Cerebral Ischemia-induced Damage and Improve Neurological Outcomes in Mice [abstract] (2010) (0)
Crystal structure of the acylated beta-lactam sensor domain of Blar1 from S. aureus (2004) (0)
Structure of Lytic Transglycosylase MltC from Escherichia coli at 2.3 A resolution. (2014) (0)
crystal structure of AmpD grown at pH 5.5 (2011) (0)
Crystal structure of Penicillin-Binding Protein 5 (PBP5) from Pseudomonas aeruginosa in apo state (2013) (0)
Antibacterials as wonder drugs and how their effectiveness is being compromised (2002) (0)
Structural analysis of the mDAP-bound form of Helicobacter pylori Csd4, a D,L-carboxypeptidase (2014) (0)
Structure-Activity Relationship for the Picolinamide Antibacterials that Selectively Target Clostridioides difficile. (2021) (0)
Crystal Structure of the complex between Q120L/Y150E mutant of AmpC and a beta-lactam inhibitor (MXG) (2003) (0)
Structure of Helicobacter pylori Csd3 from the orthorhombic crystal (2015) (0)
2007 Foundation Host-Guest Chemistry of the Peptidoglycan (2011) (0)
Faculty Opinions recommendation of Compound Uptake into E. coli Can Be Facilitated by N-Alkyl Guanidiniums and Pyridiniums. (2021) (0)
6 ALPHA HYDROXYMETHYL PENICILLOIC ACID ACYLATED ON THE TEM-1 BETA-LACTAMASE FROM ESCHERICHIA COLI (1997) (0)
Targeting extracellular matrix remodeling sensitizes glioblastoma to ionizing radiation (2022) (0)

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What Schools Are Affiliated With Shahriar Mobashery?

Shahriar Mobashery is affiliated with the following schools:

University of California, Berkeley
Weizmann Institute of Science
Wayne State University
University of Notre Dame
University of Chicago
Stanford University
University of Birmingham
University of California, San Francisco
Notre Dame University

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