Shahriar Mobashery
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Shahriar Mobasherychemistry Degrees
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Chemistry
Shahriar Mobashery's Degrees
- PhD Chemistry University of California, Berkeley
- Masters Chemical Engineering Stanford University
- Bachelors Chemical Engineering Stanford University
Why Is Shahriar Mobashery Influential?
(Suggest an Edit or Addition)Shahriar Mobashery's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Matrix metalloproteinases: structures, evolution, and diversification (1998) (757)
- Bacterial resistance to beta-lactam antibiotics: compelling opportunism, compelling opportunity. (2005) (698)
- Tackling antibiotic resistance (2011) (653)
- Versatility of Aminoglycosides and Prospects for Their Future (2003) (577)
- Aminoglycosides: Perspectives on Mechanisms of Action and Resistance and Strategies to Counter Resistance (2000) (463)
- Kinship and Diversification of Bacterial Penicillin-Binding Proteins and β-Lactamases (1998) (416)
- A Highly Specific Inhibitor of Matrix Metalloproteinase-9 Rescues Laminin from Proteolysis and Neurons from Apoptosis in Transient Focal Cerebral Ischemia (2005) (389)
- Three-dimensional structure of the bacterial cell wall peptidoglycan. (2006) (377)
- Activation of progelatinase B (MMP-9) by gelatinase A (MMP-2). (1995) (353)
- Kinetic Analysis of the Binding of Human Matrix Metalloproteinase-2 and -9 to Tissue Inhibitor of Metalloproteinase (TIMP)-1 and TIMP-2* (1997) (290)
- Bacterial cell‐wall recycling (2013) (250)
- Recent advances in MMP inhibitor design (2006) (240)
- Bacterial Resistance to β‐Lactam Antibiotics: Compelling Opportunism, Compelling Opportunity (2005) (223)
- Critical involvement of a carbamylated lysine in catalytic function of class D β-lactamases (2001) (210)
- How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function (2013) (207)
- The Basis for Resistance to β-Lactam Antibiotics by Penicillin-binding Protein 2a of Methicillin-resistant Staphylococcus aureus* (2004) (202)
- β-Lactam resistance in Staphylococcus aureus: the adaptive resistance of a plastic genome (2005) (198)
- Potent and Selective Mechanism-Based Inhibition of Gelatinases (2000) (186)
- Substrate Hydrolysis by Matrix Metalloproteinase-9* (2001) (183)
- Discoidin Domain Receptors: Unique Receptor Tyrosine Kinases in Collagen-mediated Signaling* (2013) (173)
- Cell surface association of matrix metalloproteinase-9 (gelatinase B) (2003) (161)
- Mechanism of anchoring of OmpA protein to the cell wall peptidoglycan of the gram‐negative bacterial outer membrane (2012) (157)
- Penicillin‐binding protein 2a of methicillin‐resistant Staphylococcus aureus (2014) (157)
- The future of the β-lactams. (2010) (154)
- Characterization of the Monomeric and Dimeric Forms of Latent and Active Matrix Metalloproteinase-9 (2000) (148)
- Ab initio QM/MM study of class A beta-lactamase acylation: dual participation of Glu166 and Lys73 in a concerted base promotion of Ser70. (2005) (146)
- Aminoglycosides modified by resistance enzymes display diminished binding to the bacterial ribosomal aminoacyl-tRNA site. (2002) (144)
- Design of novel antibiotics that bind to the ribosomal acyltransfer site. (2002) (136)
- Tissue Inhibitor of Metalloproteinase (TIMP)-2 Acts Synergistically with Synthetic Matrix Metalloproteinase (MMP) Inhibitors but Not with TIMP-4 to Enhance the (Membrane Type 1)-MMP-dependent Activation of Pro-MMP-2* (2000) (136)
- Aminoglycoside antibiotics. Structures, functions, and resistance. (1998) (133)
- Molecular Basis and Phenotype of Methicillin Resistance in Staphylococcus aureus and Insights into New β-Lactams That Meet the Challenge (2009) (131)
- Structural Basis for Clinical Longevity of Carbapenem Antibiotics in the Face of Challenge by the Common Class A Beta-Lactamases from Antibiotic-Resistant Bacteria (1998) (129)
- Inactivation of class A β-lactamases by clavulanic acid : the role of arginine-244 in a proposed nonconcerted sequence of events (1993) (129)
- Antimetastatic activity of a novel mechanism-based gelatinase inhibitor. (2005) (125)
- Cell-Wall Recycling of the Gram-Negative Bacteria and the Nexus to Antibiotic Resistance. (2018) (124)
- Effect of ablation or inhibition of stromal matrix metalloproteinase-9 on lung metastasis in a breast cancer model is dependent on genetic background. (2008) (124)
- Potent Mechanism-based Inhibitors for Matrix Metalloproteinases* (2005) (123)
- Complex Pattern of Membrane Type 1 Matrix Metalloproteinase Shedding (2002) (120)
- Aminoglycoside-modifying enzymes: mechanisms of catalytic processes and inhibition. (2001) (117)
- Co-opting the cell wall in fighting methicillin-resistant Staphylococcus aureus: potent inhibition of PBP 2a by two anti-MRSA beta-lactam antibiotics. (2008) (112)
- Elucidation of the role of arginine-244 in the turnover processes of class A beta-lactamases. (1992) (110)
- Synergistic, collaterally sensitive β-lactam combinations suppress resistance in MRSA (2015) (110)
- Acceleration of diabetic wound healing using a novel protease–anti-protease combination therapy (2015) (107)
- Dynamics of the Lipopolysaccharide Assembly on the Surface of Escherichia coli (1999) (107)
- Short Alkylated Peptoid Mimics of Antimicrobial Lipopeptides (2010) (104)
- Discovery of a New Class of Non-β-lactam Inhibitors of Penicillin-Binding Proteins with Gram-Positive Antibacterial Activity (2014) (103)
- Insights into class D beta-lactamases are revealed by the crystal structure of the OXA10 enzyme from Pseudomonas aeruginosa. (2000) (103)
- Discovery of antibiotic (E)-3-(3-carboxyphenyl)-2-(4-cyanostyryl)quinazolin-4(3H)-one. (2015) (101)
- The use of triphosgene in preparation of N-carboxy .alpha.-amino acid anhydrides (1992) (99)
- Lytic transglycosylases: concinnity in concision of the bacterial cell wall (2017) (97)
- Inhibition of MMP-9 by a selective gelatinase inhibitor protects neurovasculature from embolic focal cerebral ischemia (2012) (95)
- Selective Inhibition of Matrix Metalloproteinase-9 Attenuates Secondary Damage Resulting from Severe Traumatic Brain Injury (2013) (92)
- Inhibition of human prostate cancer growth, osteolysis and angiogenesis in a bone metastasis model by a novel mechanism‐based selective gelatinase inhibitor (2006) (88)
- Structural basis for carbapenemase activity of the OXA-23 β-lactamase from Acinetobacter baumannii. (2013) (88)
- The basis for resistance to beta-lactam antibiotics by penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus. (2004) (87)
- Crystal Structure of 6Alpha-Hydroxymethylpenicillanate Complexed to the Tem-1 Beta-Lactamase from Escherichia Coli: Evidence on the Mechanism of Action of a Novel Inhibitor Designed by a Computer-Aided Process (1996) (84)
- A 1.2-A snapshot of the final step of bacterial cell wall biosynthesis. (2001) (82)
- Structure–Activity Relationship for the 4(3H)-Quinazolinone Antibacterials (2016) (82)
- Messenger functions of the bacterial cell wall-derived muropeptides. (2012) (82)
- Extracellular proteases as targets for treatment of cancer metastases. (2004) (82)
- Molecular structures and dynamics of the stepwise activation mechanism of a matrix metalloproteinase zymogen: challenging the cysteine switch dogma. (2007) (80)
- Recognition of peptidoglycan and β‐lactam antibiotics by the extracellular domain of the Ser/Thr protein kinase StkP from Streptococcus pneumoniae (2011) (79)
- Design, Synthesis, and Characterization of Potent, Slow-binding Inhibitors That Are Selective for Gelatinases* (2002) (78)
- How β-Lactamases Have Driven Pharmaceutical Drug Discovery (1998) (78)
- Shedding of Discoidin Domain Receptor 1 by Membrane-type Matrix Metalloproteinases* (2013) (77)
- Reactions of all Escherichia coli lytic transglycosylases with bacterial cell wall. (2013) (76)
- Synthesis and evaluation of 1,2,4-triazolo[1,5-a]pyrimidines as antibacterial agents against Enterococcus faecium. (2015) (76)
- Structural insights into the bactericidal mechanism of human peptidoglycan recognition proteins (2007) (76)
- The complex of a designer antibiotic with a model aminoacyl site of the 30S ribosomal subunit revealed by X-ray crystallography. (2003) (75)
- Insertion of Epicatechin Gallate into the Cytoplasmic Membrane of Methicillin-resistant Staphylococcus aureus Disrupts Penicillin-binding Protein (PBP) 2a-mediated β-Lactam Resistance by Delocalizing PBP2* (2010) (71)
- Pharmacological Stabilization of Intracranial Aneurysms in Mice: A Feasibility Study (2012) (70)
- A chemical biological strategy to facilitate diabetic wound healing. (2014) (70)
- Prostate cancer-associated membrane type 1-matrix metalloproteinase: a pivotal role in bone response and intraosseous tumor growth. (2007) (70)
- The sentinel role of peptidoglycan recycling in the β-lactam resistance of the Gram-negative Enterobacteriaceae and Pseudomonas aeruginosa. (2014) (70)
- Structure-activity relationship for the oxadiazole class of antibiotics. (2015) (70)
- Activation for catalysis of penicillin-binding protein 2a from methicillin-resistant Staphylococcus aureus by bacterial cell wall. (2005) (70)
- A structure-based analysis of the inhibition of class A beta-lactamases by sulbactam. (1994) (69)
- Structural aspects for evolution of beta-lactamases from penicillin-binding proteins. (2003) (69)
- The Importance of a Critical Protonation State and the Fate of the Catalytic Steps in Class A β-Lactamases and Penicillin-binding Proteins* (2004) (69)
- Structural consequences of the inhibitor-resistant Ser130Gly substitution in TEM beta-lactamase. (2005) (68)
- Resistance to β-Lactam Antibiotics and Its Mediation by the Sensor Domain of the Transmembrane BlaR Signaling Pathway in Staphylococcus aureus * 210 (2003) (68)
- Quest for selectivity in inhibition of matrix metalloproteinases. (2004) (67)
- Crystal structures of penicillin-binding protein 6 from Escherichia coli. (2009) (65)
- Roles of Matrix Metalloproteinases in Flow-Induced Outward Vascular Remodeling (2009) (65)
- Structural and Functional Insights into Peptidoglycan Access for the Lytic Amidase LytA of Streptococcus pneumoniae (2014) (64)
- Insights into pneumococcal fratricide from the crystal structures of the modular killing factor LytC (2010) (64)
- Disruption of Allosteric Response as an Unprecedented Mechanism of Resistance to Antibiotics (2014) (64)
- Effects on Substrate Profile by Mutational Substitutions at Positions 164 and 179 of the Class A TEMpUC19 β-Lactamase from Escherichia coli* (1999) (63)
- Effect of synthetic matrix metalloproteinase inhibitors on lipopolysaccharide-induced blood–brain barrier opening in rodents: Differences in response based on strains and solvents (2007) (63)
- Mechanistic Basis for the Emergence of Catalytic Competence against Carbapenem Antibiotics by the GES Family of β-Lactamases (2009) (63)
- Elucidation of the Molecular Recognition of Bacterial Cell Wall by Modular Pneumococcal Phage Endolysin CPL-1* (2007) (61)
- High-resolution X-ray structure of an acyl-enzyme species for the class D OXA-10, β-lactamase (2002) (61)
- Three Decades of the Class A β-Lactamase Acyl-Enzyme (2009) (59)
- Resolving the antibiotic paradox: progress in understanding drug resistance and development of new antibiotics. (1998) (59)
- Selection and Characterization of β-Lactam–β-Lactamase Inactivator-Resistant Mutants following PCR Mutagenesis of the TEM-1 β-Lactamase Gene (1998) (59)
- Matrix metalloproteinase 2 inhibition: combined quantum mechanics and molecular mechanics studies of the inhibition mechanism of (4-phenoxyphenylsulfonyl)methylthiirane and its oxirane analogue. (2009) (58)
- Activation of BlaR1 Protein of Methicillin-resistant Staphylococcus aureus, Its Proteolytic Processing, and Recovery from Induction of Resistance* (2011) (58)
- LOSS OF INDIVIDUAL ELECTROSTATIC INTERACTIONS BETWEEN AMINOGLYCOSIDE ANTIBIOTICS AND RESISTANCE ENZYMES AS AN EFFECTIVE MEANS TO OVERCOMING BACTERIAL DRUG RESISTANCE (1995) (57)
- Bacterial AmpD at the crossroads of peptidoglycan recycling and manifestation of antibiotic resistance. (2009) (56)
- An Antibiotic Cloaked by Its Own Resistance Enzyme (1999) (56)
- Characterization of the bifunctional aminoglycoside-modifying enzyme ANT(3'')-Ii/AAC(6')-IId from Serratia marcescens. (2006) (55)
- Validation of Matrix Metalloproteinase-9 (MMP-9) as a Novel Target for Treatment of Diabetic Foot Ulcers in Humans and Discovery of a Potent and Selective Small-Molecule MMP-9 Inhibitor That Accelerates Healing. (2018) (55)
- An antibiotic-resistance enzyme from a deep-sea bacterium. (2010) (54)
- Crystal Structures of Bacterial Peptidoglycan Amidase AmpD and an Unprecedented Activation Mechanism* (2011) (54)
- Crystal structure of CbpF, a bifunctional choline‐binding protein and autolysis regulator from Streptococcus pneumoniae (2009) (54)
- Conformational Dynamics in Penicillin-Binding Protein 2a of Methicillin-Resistant Staphylococcus aureus, Allosteric Communication Network and Enablement of Catalysis. (2017) (53)
- A Convenient Triphosgene-Mediated Synthesis of Symmetric Carboxylic Acid Anhydrides (1994) (53)
- X-ray Absorption Studies of Human Matrix Metalloproteinase-2 (MMP-2) Bound to a Highly Selective Mechanism-based Inhibitor (2001) (52)
- β-Lactam antibiotics, β-lactamases and bacterial resistance (1998) (52)
- Discrete steps in sensing of beta-lactam antibiotics by the BlaR1 protein of the methicillin-resistant Staphylococcus aureus bacterium. (2006) (52)
- β-Lactam Resistance Mechanisms: Gram-Positive Bacteria and Mycobacterium tuberculosis. (2016) (51)
- Synthetic Peptidoglycan Motifs for Germination of Bacterial Spores (2010) (51)
- Total synthesis of N-acetylglucosamine-1,6-anhydro-N-acetylmuramylpentapeptide and evaluation of its turnover by AmpD from Escherichia coli. (2009) (51)
- Mechanistic characterization of the bifunctional aminoglycoside-modifying enzyme AAC(3)-Ib/AAC(6')-Ib' from Pseudomonas aeruginosa. (2007) (50)
- Synthesis of chiral 2-(4-phenoxyphenylsulfonylmethyl)thiiranes as selective gelatinase inhibitors. (2005) (50)
- Molecular dynamics at the root of expansion of function in the M69L inhibitor-resistant TEM beta-lactamase from Escherichia coli. (2002) (50)
- Roles of Matrix Metalloproteinases in Cutaneous Wound Healing (2016) (50)
- X-ray crystal structure of the acylated beta-lactam sensor domain of BlaR1 from Staphylococcus aureus and the mechanism of receptor activation for signal transduction. (2004) (49)
- MECHANISM OF TURNOVER OF IMIPENEM BY THE TEM BETA -LACTAMASE REVISITED (1995) (48)
- Catalytic mechanism of penicillin-binding protein 5 of Escherichia coli. (2007) (47)
- MOLECULAR BASES FOR INTERACTIONS BETWEEN BETA -LACTAM ANTIBIOTICS AND BETA-LACTAMASES (1997) (47)
- A Novel β-Lactamase Activity from a Penicillin-binding Protein of Treponema pallidum and Why Syphilis Is Still Treatable with Penicillin* (2004) (46)
- Mechanistic Basis for the Action of New Cephalosporin Antibiotics Effective against Methicillin- and Vancomycin-resistant Staphylococcus aureus* (2006) (46)
- Reversal of clavulanate resistance conferred by a Ser-244 mutant of TEM-1 beta-lactamase as a result of a second mutation (Arg to Ser at position 164) that enhances activity against ceftazidime (1994) (46)
- Cleavage at the stem region releases an active ectodomain of the membrane type 1 matrix metalloproteinase. (2005) (45)
- Resolving the Antibiotic Paradox (1998) (45)
- X-ray structure of the Asn276Asp variant of the Escherichia coli TEM-1 beta-lactamase: direct observation of electrostatic modulation in resistance to inactivation by clavulanic acid. (1999) (45)
- Nuances of Mechanisms and Their Implications for Evolution of the Versatile β-Lactamase Activity: From Biosynthetic Enzymes to Drug Resistance Factors (1997) (44)
- The First Structural and Mechanistic Insights for Class D beta-Lactamases: Evidence for a Novel Catalytic Process for Turnover of beta-Lactam Antibiotics (2000) (44)
- Synthetic peptidoglycan substrates for penicillin-binding protein 5 of Gram-negative bacteria. (2004) (44)
- Reactions of the three AmpD enzymes of Pseudomonas aeruginosa. (2013) (43)
- Structural Basis for Potent Slow Binding Inhibition of Human Matrix Metalloproteinase-2 (MMP-2)* (2003) (43)
- Lytic transglycosylase MltB of Escherichia coli and its role in recycling of peptidoglycan strands of bacterial cell wall. (2008) (43)
- Cell-wall remodeling by the zinc-protease AmpDh3 from Pseudomonas aeruginosa. (2013) (42)
- Structure and Cell Wall Cleavage by Modular Lytic Transglycosylase MltC of Escherichia coli (2014) (42)
- MECHANISM-BASED INACTIVATION OF BACTERIAL AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASES (1995) (42)
- High-resolution crystal structure of MltE, an outer membrane-anchored endolytic peptidoglycan lytic transglycosylase from Escherichia coli. (2011) (42)
- Lysine carboxylation in proteins: OXA‐10 β‐lactamase (2005) (42)
- Inhibition of the NMC-A β-Lactamase by a Penicillanic Acid Derivative and the Structural Bases for the Increase in Substrate Profile of This Antibiotic Resistance Enzyme (1998) (41)
- Testosterone-Induced Matrix Metalloproteinase Activation Is a Checkpoint for Neuronal Addition to the Adult Songbird Brain (2008) (41)
- Design, synthesis, and evaluation of a mechanism-based inhibitor for gelatinase A. (2005) (41)
- Effects of Asp-179 mutations in TEMpUC19 beta-lactamase on susceptibility to beta-lactams (1995) (41)
- Source of Phosphate in the Enzymic Reaction as a Point of Distinction among Aminoglycoside 2″-Phosphotransferases* (2009) (40)
- Structural Analysis of the Role of Pseudomonas aeruginosa Penicillin-Binding Protein 5 in β-Lactam Resistance (2013) (40)
- Active Site Ring‐Opening of a Thiirane Moiety and Picomolar Inhibition of Gelatinases (2009) (40)
- A mechanism-based inhibitor targeting the DD-transpeptidase activity of bacterial penicillin-binding proteins. (2003) (40)
- Selective water-soluble gelatinase inhibitor prodrugs. (2011) (39)
- Restoration of Susceptibility of Methicillin-resistant Staphylococcus aureus to β-Lactam Antibiotics by Acidic pH (2008) (39)
- Interactions of designer antibiotics and the bacterial ribosomal aminoacyl-tRNA site. (2006) (39)
- Phosphoryl transfer by aminoglycoside 3'-phosphotransferases and manifestation of antibiotic resistance. (2005) (39)
- N-Glycosylation pattern of the zymogenic form of human matrix metalloproteinase-9. (2002) (38)
- Mutational Replacement of Leu-293 in the Class C Enterobacter cloacae P99 β-Lactamase Confers Increased MIC of Cefepime (2002) (38)
- The bifunctional enzymes of antibiotic resistance. (2009) (38)
- Purification, characterization, and investigation of the mechanism of aminoglycoside 3'-phosphotransferase type Ia. (1995) (38)
- Strategy in inhibition of cathepsin B, a target in tumor invasion and metastasis. (2004) (37)
- Synthesis of a fragment of bacterial cell wall. (2004) (37)
- Endless Resistance. Endless Antibiotics? (2016) (37)
- From Genome to Proteome to Elucidation of Reactions for All Eleven Known Lytic Transglycosylases from Pseudomonas aeruginosa. (2017) (37)
- Metabolism of a Highly Selective Gelatinase Inhibitor Generates Active Metabolite (2007) (37)
- Investigation of the mechanism of the cell wall DD-carboxypeptidase reaction of penicillin-binding protein 5 of Escherichia coli by quantum mechanics/molecular mechanics calculations. (2008) (37)
- Properties of a Bifunctional Bacterial Antibiotic Resistance Enzyme That Catalyzes ATP-Dependent 2‘‘-Phosphorylation and Acetyl-CoA-Dependent 6‘-Acetylation of Aminoglycosides (1997) (36)
- A light-inactivated antibiotic. (2000) (36)
- Endogenous matrix metalloproteinases 2 and 9 regulate activation of CD4+ and CD8+ T cells. (2011) (36)
- Class C β-Lactamases Operate at the Diffusion Limit for Turnover of Their Preferred Cephalosporin Substrates (1999) (36)
- Facilitation of the .DELTA.2 .fwdarw. .DELTA.1 pyrroline tautomerization of carbapenem antibiotics by the highly conserved arginine-244 of class A .beta.-lactamases during the course of turnover (1992) (35)
- The oxadiazole antibacterials. (2016) (35)
- Muropeptides in Pseudomonas aeruginosa and their Role as Elicitors of β-Lactam-Antibiotic Resistance. (2016) (35)
- Glycosylation at Asn211 Regulates the Activation State of the Discoidin Domain Receptor 1 (DDR1)* (2014) (35)
- Pronounced Diversity in Electronic and Chemical Properties between the Catalytic Zinc Sites of Tumor Necrosis Factor-α-converting Enzyme and Matrix Metalloproteinases despite Their High Structural Similarity* (2004) (35)
- Identification of colchicine in placental blood from patients using herbal medicines. (2001) (35)
- Three decades of the class A beta-lactamase acyl-enzyme. (2009) (35)
- Design, Synthesis, and Evaluation of a Potent Mechanism-Based Inhibitor for the TEM .beta.-Lactamase with Implications for the Enzyme Mechanism (1995) (35)
- Reaction products and the X-ray structure of AmpDh2, a virulence determinant of Pseudomonas aeruginosa. (2013) (34)
- Inhibitors for Bacterial Cell-Wall Recycling. (2012) (34)
- Constructing and deconstructing the bacterial cell wall (2019) (33)
- Three-dimensional QSAR analysis and design of new 1,2,4-oxadiazole antibacterials. (2016) (33)
- Conscripting β-Lactamase for Use in Drug Delivery. Synthesis and Biological Activity of a Cephalosporin C10-Ester of an Antibiotic Dipeptide. (1986) (33)
- Mechanism-based profiling of MMPs. (2010) (32)
- Selective gelatinase inhibitor neuroprotective agents cross the blood-brain barrier. (2012) (32)
- Critical hydrogen bonding by serine 235 for cephalosporinase activity of TEM-1 beta-lactamase (1993) (32)
- Exploration of the structure-activity relationship of 1,2,4-oxadiazole antibiotics. (2015) (32)
- Substrate recognition and catalysis by LytB, a pneumococcal peptidoglycan hydrolase involved in virulence (2015) (32)
- Structural and mechanistic aspects of evolution of beta-lactamases and penicillin-binding proteins. (1999) (32)
- A Potent Gelatinase Inhibitor with Anti‐Tumor‐Invasive Activity and its Metabolic Disposition (2009) (31)
- O-phenyl carbamate and phenyl urea thiiranes as selective matrix metalloproteinase-2 inhibitors that cross the blood-brain barrier. (2013) (31)
- A practical synthesis of nitrocefin. (2005) (31)
- Catalytic Spectrum of the Penicillin-Binding Protein 4 of Pseudomonas aeruginosa, a Nexus for the Induction of β-Lactam Antibiotic Resistance (2014) (30)
- How beta-lactamases have driven pharmaceutical drug discovery. From mechanistic knowledge to clinical circumvention. (1998) (30)
- Sulfonate-containing thiiranes as selective gelatinase inhibitors. (2011) (30)
- Recognition of aminoglycoside antibiotics by enterococcal-staphylococcal aminoglycoside 3'-phosphotransferase type IIIa: role of substrate amino groups (1996) (30)
- Complications from dual roles of sodium hydride as a base and as a reducing agent. (2009) (30)
- Fluorinated aminoglycosides and their mechanistic implication for aminoglycoside 3'-phosphotransferases from Gram-negative bacteria. (2004) (29)
- Reactions of Escherichia coli TEM beta-lactamase with cephalothin and with C10-dipeptidyl cephalosporin esters. (1986) (29)
- The Quinazolinone Allosteric Inhibitor of PBP 2a Synergizes with Piperacillin and Tazobactam against Methicillin-Resistant Staphylococcus aureus (2019) (29)
- Thermodynamics of interactions of vancomycin and synthetic surrogates of bacterial cell wall. (2006) (29)
- Purification and characterization of aminoglycoside 3'-phosphotransferase type IIa and kinetic comparison with a new mutant enzyme (1994) (29)
- Structural basis for progression toward the carbapenemase activity in the GES family of β-lactamases. (2012) (29)
- Conformational Transition in the Aminoacyl t‐RNA Site of the Bacterial Ribosome both in the Presence and Absence of an Aminoglycoside Antibiotic (2007) (28)
- Lytic transglycosylases LtgA and LtgD perform distinct roles in remodeling, recycling and releasing peptidoglycan in Neisseria gonorrhoeae (2016) (28)
- Facile chloride substitution of activated alcohols by triphosgene : application to cephalosporin chemistry (1991) (28)
- Phosphorylation of BlaR1 in Manifestation of Antibiotic Resistance in Methicillin-Resistant Staphylococcus aureus and Its Abrogation by Small Molecules. (2015) (28)
- Tethered bisubstrate derivatives as probes for mechanism and as inhibitors of aminoglycoside 3'-phosphotransferases. (2000) (28)
- β-Lactams against the Fortress of the Gram-Positive Staphylococcus aureus Bacterium. (2020) (28)
- Insight into the complex and dynamic process of activation of matrix metalloproteinases. (2001) (28)
- Lysine N(zeta)-decarboxylation in the BlaR1 protein from Staphylococcus aureus at the root of its function as an antibiotic sensor. (2007) (28)
- Design and characterization of a metalloproteinase inhibitor-tethered resin for the detection of active MMPs in biological samples. (2006) (27)
- Dissection of events in the resistance to β-lactam antibiotics mediated by the protein BlaR1 from Staphylococcus aureus. (2012) (26)
- Orthologous and Paralogous AmpD Peptidoglycan Amidases from Gram-Negative Bacteria (2016) (26)
- Regulation of the Expression of the β-Lactam Antibiotic-Resistance Determinants in Methicillin-Resistant Staphylococcus aureus (MRSA) (2014) (26)
- QM/MM Studies of the Matrix Metalloproteinase 2 (MMP2) Inhibition Mechanism of (S)-SB-3CT and its Oxirane Analogue. (2010) (26)
- Muropeptide Binding and the X-ray Structure of the Effector Domain of the Transcriptional Regulator AmpR of Pseudomonas aeruginosa. (2017) (25)
- Evidence for Structural Elasticity of Class A β-Lactamases in the Course of Catalytic Turnover of the Novel Cephalosporin Cefepime (1996) (25)
- A computational evaluation of the mechanism of penicillin-binding protein-catalyzed cross-linking of the bacterial cell wall. (2011) (25)
- X-ray Absorption Studies of Human Matrix Metalloproteinase-2 (MMP-2) Bound to a Highly Selective Mechanism-based Inhibitor COMPARISON WITH THE LATENT AND ACTIVE FORMS OF THE ENZYME* (2001) (25)
- The external PASTA domain of the essential serine/threonine protein kinase PknB regulates mycobacterial growth (2015) (24)
- Synthesis of an inhibitor-tethered resin for detection of active matrix metalloproteinases involved in disease. (2006) (24)
- Structure-Activity Relationship for Thiirane-Based Gelatinase Inhibitors. (2012) (24)
- The use of neamine as a molecular template: inactivation of bacterial antibiotic resistance enzyme aminoglycoside 3'-phosphotransferase type IIa. (1998) (24)
- Structural insight into the binding motifs for the calcium ion and the non-catalytic zinc in matrix metalloproteases. (1998) (24)
- DFT studies of the ring-opening mechanism of SB-3CT, a potent inhibitor of matrix metalloproteinase 2. (2009) (24)
- Matrix metalloproteinase 2 (MMP2) inhibition: DFT and QM/MM studies of the deprotonation-initialized ring-opening reaction of the sulfoxide analogue of SB-3CT. (2010) (24)
- Shared functional attributes between the mecA gene product of Staphylococcus sciuri and penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus. (2007) (24)
- PENEM BRL 42715 : AN EFFECTIVE INACTIVATOR FOR BETA -LACTAMASES (1995) (24)
- The Tipper-Strominger Hypothesis and Triggering of Allostery in Penicillin-Binding Protein 2a of Methicillin-Resistant Staphylococcus aureus (MRSA). (2015) (24)
- Activation by Allostery in Cell-Wall Remodeling by a Modular Membrane-Bound Lytic Transglycosylase from Pseudomonas aeruginosa. (2016) (23)
- Whole-Genome Shotgun Sequencing of Two β-Proteobacterial Species in Search of the Bulgecin Biosynthetic Cluster (2017) (23)
- Resistance to the third-generation cephalosporin ceftazidime by a deacylation-deficient mutant of the TEM β-lactamase by the uncommon covalent-trapping mechanism. (2011) (23)
- Lysine Nζ-Decarboxylation Switch and Activation of the β-Lactam Sensor Domain of BlaR1 Protein of Methicillin-resistant Staphylococcus aureus* (2011) (23)
- Allostery, Recognition of Nascent Peptidoglycan, and Cross-linking of the Cell Wall by the Essential Penicillin-Binding Protein 2x of Streptococcus pneumoniae. (2018) (23)
- Characterization of the β-Lactam Antibiotic Sensor Domain of the MecR1 Signal Sensor/Transducer Protein from Methicillin-Resistant Staphylococcus aureus† (2007) (23)
- Purification of recombinant pp60v-src protein tyrosine kinase and phosphorylation of peptides with different secondary structure preference. (1989) (23)
- Amidase Activity of AmiC Controls Cell Separation and Stem Peptide Release and Is Enhanced by NlpD in Neisseria gonorrhoeae* (2016) (23)
- Inactivation of alanine racemase by beta-chloro-L-alanine released enzymatically from amino acid and peptide C10-esters of deacetylcephalothin. (1987) (22)
- Kinetic mechanism of enterococcal aminoglycoside phosphotransferase 2"-Ib. (2007) (22)
- A new approach to the preparation of N-carboxy .alpha.-amino acid anhydrides (1985) (22)
- Exolytic and endolytic turnover of peptidoglycan by lytic transglycosylase Slt of Pseudomonas aeruginosa (2018) (22)
- β-Lactam Antibiotics (2010) (22)
- Total Syntheses of Bulgecins A, B, and C and Their Bactericidal Potentiation of the β-Lactam Antibiotics (2018) (22)
- Potent mechanism-based inhibition of the TEM-1 .beta.-lactamase by novel N-sulfonyloxy .beta.-lactams (1995) (22)
- A dynamic structure for the acyl-enzyme species of the antibiotic aztreonam with the Citrobacter freundii beta-lactamase revealed by infrared spectroscopy and molecular dynamics simulations. (2003) (22)
- Identification of Products of Inhibition of GES-2 β-Lactamase by Tazobactam by X-ray Crystallography and Spectrometry* (2011) (22)
- The Cell Shape-determining Csd6 Protein from Helicobacter pylori Constitutes a New Family of l,d-Carboxypeptidase* (2015) (22)
- Structural Insights into the Catalytic Domains of Human Matrix Metalloprotease-2 and Human Matrix Metalloprotease-9: Implications for Substrate Specificities (1997) (21)
- Characterization of the Dimerization Interface of Membrane Type 4 (MT4)-Matrix Metalloproteinase* (2011) (21)
- Investigation of signal transduction routes within the sensor/transducer protein BlaR1 of Staphylococcus aureus. (2015) (21)
- Identification and Role of the Homodimerization Interface of the Glycosylphosphatidylinositol-anchored Membrane Type 6 Matrix Metalloproteinase (MMP25)* (2008) (21)
- A Type VI secretion system delivers a cell-wall amidase to target bacterial competitors. (2020) (21)
- Structural basis of denuded glycan recognition by SPOR domains in bacterial cell division (2019) (20)
- Hydrolysis of ATP by Aminoglycoside 3′-Phosphotransferases (2006) (20)
- Slt, MltD, and MltG of Pseudomonas aeruginosa as Targets of Bulgecin A in Potentiation of β-Lactam Antibiotics. (2019) (20)
- Preparation of ceph-3-em esters unaccompanied by .DELTA.3 .fwdarw. .DELTA.2 isomerization of the cephalosporin (1986) (20)
- 1H-NMR analysis of copper-aminoglycoside complexes in solution and its implication for regioselective modification of multifunctional aminoglycoside antibiotics (1998) (20)
- Exploration of the Structural Space in 4(3H)-Quinazolinone Antibacterials. (2020) (20)
- Catalytic Cycle of the N-Acetylglucosaminidase NagZ from Pseudomonas aeruginosa. (2017) (20)
- N-Sulfonyloxy-β-lactam Inhibitors for β-Lactamases (2000) (19)
- Mechanism of the Escherichia coli MltE lytic transglycosylase, the cell-wall-penetrating enzyme for Type VI secretion system assembly (2018) (19)
- Transferase Versus Hydrolase: The Role of Conformational Flexibility in Reaction Specificity. (2017) (19)
- Conscripting the Active-Site Zinc Ion in Carboxypeptidase A in Inactivation Chemistry by a New Type of Irreversible Enzyme Inactivator (1994) (19)
- Bacterial Antibiotic Resistance (2003) (19)
- Inhibition of the Broad Spectrum Nonmetallocarbapenamase of Class A (NMC-A) β-Lactamase from Enterobacter cloacae by Monocyclic β-Lactams* 210 (1999) (18)
- A convenient synthesis of a selective gelatinase inhibitor as an antimetastatic agent. (2004) (18)
- In Vitro and In Vivo Synergy of the Oxadiazole Class of Antibacterials with β-Lactams (2016) (18)
- Structure of Csd3 from Helicobacter pylori, a cell shape-determining metallopeptidase (2015) (18)
- Design and synthesis of a structurally constrained aminoglycoside. (2007) (18)
- 6-(Hydroxyalkyl)penicillanates as Probes for Mechanisms of β-Lactamases (2000) (17)
- Why clinically used tazobactam and sulbactam are poor inhibitors of OXA-10 beta-lactamase: Raman crystallographic evidence. (2008) (17)
- The Allosteric Site for the Nascent Cell Wall in Penicillin-Binding Protein 2a: An Achilles' Heel of Methicillin-Resistant Staphylococcus aureus. (2015) (17)
- Early Abrogation of Gelatinase Activity Extends the Time Window for tPA Thrombolysis after Embolic Focal Cerebral Ischemia in Mice (2018) (17)
- Structural Basis of the Heterodimer Formation between Cell Shape-Determining Proteins Csd1 and Csd2 from Helicobacter pylori (2016) (17)
- Identification of amino acid residues involved in substrate recognition by the catalytic subunit of bovine cyclic AMP dependent protein kinase: peptide-based affinity labels. (1988) (17)
- Host-guest chemistry of the peptidoglycan. (2010) (16)
- Binding of the gene repressor BlaI to the bla operon in methicillin-resistant Staphylococcus aureus. (2010) (16)
- Structural basis for the recognition of muramyltripeptide by Helicobacter pylori Csd4, a d,l-carboxypeptidase controlling the helical cell shape (2014) (16)
- Water-Soluble MMP-9 Inhibitor Reduces Lesion Volume after Severe Traumatic Brain Injury. (2015) (16)
- The crystal structure of the major pneumococcal autolysin LytA in complex with a large peptidoglycan fragment reveals the pivotal role of glycans for lytic activity (2016) (16)
- Crystallographic and computational insight on the mechanism of zinc-ion-dependent inactivation of carboxypeptidase a by 2-benzyl-3-iodopropanoate. (1996) (15)
- Computational investigation of irreversible inactivation of the zinc-dependent protease carboxypeptidase A. (2005) (15)
- Aminoglycoside Antibiotics: Structures and Mechanisms of Action (2001) (14)
- Selection and characterization of beta-lactam-beta-lactamase inactivator-resistant mutants following PCR mutagenesis of the TEM-1 beta-lactamase gene. (1998) (14)
- Mechanistic and clinical aspects of beta-lactam antibiotics and beta-lactamases. (1999) (14)
- Metabolism of (4‐Phenoxyphenylsulfonyl)methylthiirane, a Selective Gelatinase Inhibitor (2008) (14)
- Revealing cell-surface intramolecular interactions in the BlaR1 protein of methicillin-resistant Staphylococcus aureus by NMR spectroscopy. (2014) (14)
- Synthesis, Kinetic Characterization and Metabolism of Diastereomeric 2‐(1‐(4‐Phenoxyphenylsulfonyl)ethyl)thiiranes as Potent Gelatinase and MT1‐MMP Inhibitors (2009) (14)
- Use of silver carbonate in the Wittig reaction. (2013) (14)
- From genes to sequences to antibiotics: prospects for future developments from microbial genomics. (2000) (14)
- AAC(3)-XI, a New Aminoglycoside 3-N-Acetyltransferase from Corynebacterium striatum (2015) (14)
- An Amino Acid Position at Crossroads of Evolution of Protein Function (2012) (13)
- Regioselective Control of the SNAr Amination of 5-Substituted-2,4-Dichloropyrimidines Using Tertiary Amine Nucleophiles. (2015) (13)
- Turnover of Bacterial Cell Wall by SltB3, a Multidomain Lytic Transglycosylase of Pseudomonas aeruginosa. (2016) (13)
- N-(tert-Butoxycarbonyloxy)-5-norbornene-endo-2,3-dicarboximide, a Reagent for the Regioselective Introduction of the tert-Butoxycarbonyl (BOC) Protective Group at Unhindered Amines: Application to Amino glycoside Chemistry (1994) (13)
- Conjoint molecules of cephalosporins and aminoglycosides (2001) (13)
- Aminoglycoside 2″-Phosphotransferase Type IIIa from Enterococcus* (2008) (13)
- Potentiation of the activity of β-lactam antibiotics by farnesol and its derivatives. (2018) (12)
- Peptidoglycan reshaping by a noncanonical peptidase for helical cell shape in Campylobacter jejuni (2020) (12)
- The first mechanism-based inactivators for angiotensin-converting enzyme. (1992) (12)
- Mutational and Structural Analyses of the Hinge Region of Membrane Type 1-Matrix Metalloproteinase and Enzyme Processing* (2005) (12)
- Structure-Activity Relationship for the Oxadiazole Class of Antibacterials. (2019) (12)
- The Basis for Resistance to b -Lactam Antibiotics by Penicillin-Binding Protein 2a (PBP2a) of Methicillin-Resistant Staphylococcus aureus (2004) (12)
- Mechanism-based inhibition of zinc proteases. (2001) (12)
- MT1-MMP shedding involves an ADAM and is independent of its localization in lipid rafts. (2006) (12)
- Quantification of the extent of attenuation of the rate of turnover chemistry of the TEM-1 β-lactamase by the α-1R-hydroxyethyl group in substrates (1996) (12)
- Selective Inhibition of MMP-2 Does Not Alter Neurological Recovery after Spinal Cord Injury. (2016) (12)
- Design of an effective mechanism-based inactivator for a zinc protease. (1990) (12)
- Elucidation of the structure of the membrane anchor of penicillin-binding protein 5 of Escherichia coli. (2010) (11)
- Targeting renal dipeptidase (dehydropeptidase I) for inactivation by mechanism-based inactivators. (1991) (11)
- 13 Bacterial Cell Wall Morphology and Biochemistry (2009) (11)
- Regiospecific syntheses of 6alpha-(1R-Hydroxyoctyl)penicillanic acid and 6beta-(1R-hydroxyoctyl)penicillanic acid as mechanistic probes of class D beta-lactamases. (2009) (11)
- Sulfonylation-induced N- to O-acetyl migration in 2-acetamidoethanol derivatives. (2010) (11)
- Metabolism of (4-phenoxyphenylsulfonyl) methylthiirane, a selective gelatinase inhibitor. (2008) (11)
- Transition State Stabilization (2002) (10)
- Expression of active matrix metalloproteinase‐9 as a likely contributor to the clinical failure of aclerastide in treatment of diabetic foot ulcers (2018) (10)
- The future of the b-lactams (2010) (10)
- Conformational analyses of thiirane-based gelatinase inhibitors. (2008) (10)
- 8.13 – Enzymology of Bacterial Resistance (2010) (10)
- Selective MMP-9 Inhibitor (R)-ND-336 Alone or in Combination with Linezolid Accelerates Wound Healing in Infected Diabetic Mice. (2020) (10)
- Synthesis and NMR characterization of (Z,Z,Z,Z,E,E,ω)-heptaprenol. (2012) (10)
- Unconventional Antibacterials and Adjuvants. (2021) (10)
- Peptidic mechanism-based inactivators for carboxypeptidase A. (1991) (10)
- Strategies to Counter Resistance Mechanisms of Action and Resistance and Aminoglycosides : Perspectives on (2000) (10)
- Are matrix metalloproteinases relevant therapeutic targets for prostate cancer bone metastasis? (2008) (10)
- The X‐Ray Structure of Carboxypeptidase A Inhibited by a Thiirane Mechanism‐Based Inhibitor (2010) (10)
- Mutations in mmpL and in the Cell Wall Stress Stimulon Contribute to Resistance to Oxadiazole Antibiotics in Methicillin-Resistant Staphylococcus aureus (2014) (9)
- MMP-9 inhibitors impair learning in spontaneously hypertensive rats (2018) (9)
- Turnover of Bacterial Cell Wall by SltB3, a Multidomain Lytic Transglycosylase of Pseudomonas aeruginosa. (2016) (9)
- Catalytic Cycle of Glycoside Hydrolase BglX from Pseudomonas aeruginosa and Its Implication in Biofilm Formation. (2019) (9)
- Lysine carboxylation in proteins: OXA-10 beta-lactamase. (2005) (9)
- The Use of Triphosgene in Preparation of N-Carboxy-α-amino Acid Anhydrides. (1992) (9)
- Insights into the three-dimensional structure of crotalase: Implications for biological activity and substrate specificity (1997) (9)
- High-resolution X-ray structure of an acyl-enzyme species for the class D OXA-10 beta-lactamase. (2002) (9)
- Protonation states of active‐site lysines of penicillin‐binding protein 6 from Escherichia coli and the mechanistic implications (2014) (9)
- Allosteric Inhibition of Bacterial Targets: An Opportunity for Discovery of Novel Antibacterial Classes (2017) (8)
- Stereoselective reduction of alpha-bromopenicillanates by tributylphosphine. (2000) (8)
- Cinnamonitrile Adjuvants Restore Susceptibility to β-Lactams against Methicillin-Resistant Staphylococcus aureus. (2019) (8)
- Crystallization and preliminary X-ray diffraction analysis of the lytic transglycosylase MltE from Escherichia coli. (2011) (8)
- The Natural Product Essramycin and Three of Its Isomers Are Devoid of Antibacterial Activity. (2016) (8)
- Exploring the functional space of thiiranes as gelatinase inhibitors using click chemistry. (2011) (8)
- Molecular Bases for Interactions Between β‐Lactam Antibiotics and β‐Lactamases (1997) (8)
- b -Lactam Resistance Mechanisms: Gram-Positive Bacteria and Mycobacterium tuberculosis (2016) (8)
- Characterization of a selective inhibitor for matrix metalloproteinase-8 (MMP-8) (2014) (8)
- Hyperbaric oxygen therapy accelerates wound healing in diabetic mice by decreasing active matrix metalloproteinase‐9 (2019) (8)
- A novel approach to deacylation of ceph-3-em esters (1986) (8)
- Resistance to beta-Lactam Antibiotics Mediated by beta-Lactamases: Structure, Mechanism, and Evolution (2007) (7)
- Methodologies in Syntheses of Aminoglycoside Antibiotics (2001) (7)
- Activities of Oxadiazole Antibacterials against Staphylococcus aureus and Other Gram-Positive Bacteria (2018) (7)
- Chapter 3:The β-Lactam (Azetidin-2-one) as a Privileged Ring in Medicinal Chemistry (2015) (7)
- X-ray Structure of Catenated Lytic Transglycosylase SltB1. (2017) (7)
- Evaluation of inhibition of the carbenicillin‐hydrolyzing β‐lactamase PSE‐4 by the clinically used mechanism‐based inhibitors (2000) (7)
- Discovery of Mechanism-Based Inactivators for Human Pancreatic Carboxypeptidase A from a Focused Synthetic Library. (2017) (7)
- Cytoplasmic-Membrane Anchoring of a Class A β-Lactamase and Its Capacity in Manifesting Antibiotic Resistance (2007) (7)
- Templates for design of inhibitors for serine proteases: application of the program DOCK to the discovery of novel inhibitors for thrombin. (1998) (7)
- Nanomolecular and Supramolecular Paths toward Peptidoglycan Structure (2006) (6)
- Reactions of All E . coli Lytic Transglycosylases with Bacterial Cell (2013) (6)
- Deciphering the Nature of Enzymatic Modifications of Bacterial Cell Walls (2017) (6)
- HYDROLYSIS OF ATP BY AMINOGLYCOSIDE 3’- PHOSPHOTRANSFERASES: AN UNEXPECTED COST TO BACTERIA FOR HARBORING AN ANTIBIOTIC RESISTANCE ENZYME (2005) (6)
- Characterization of the beta-lactam antibiotic sensor domain of the MecR1 signal sensor/transducer protein from methicillin-resistant Staphylococcus aureus. (2007) (6)
- Crystal structure of CbpF, a bifunctional choline‐binding protein and autolysis regulator from Streptococcus pneumoniae (2009) (5)
- A mechanism-based inactivation study of neutral endopeptidase 24.11. (1993) (5)
- Monitoring beta-lactamase activity in vivo by 13C nuclear magnetic resonance spectroscopy (1988) (5)
- Preparation of Ceph-3-em Esters Unaccompanied by δ3 → δ2 Isomerization of the Cephalosporin. (1987) (5)
- Corrigendum: Muropeptides in Pseudomonas aeruginosa and their Role as Elicitors of β-Lactam-Antibiotic Resistance. (2016) (5)
- Faculty Opinions recommendation of Ultra-large library docking for discovering new chemotypes. (2019) (5)
- Exploitation of Conformational Dynamics in Imparting Selective Inhibition for Related Matrix Metalloproteinases. (2017) (5)
- Inhibition of β-Lactamases by 6,6-Bis(hydroxylmethyl)penicillanate (2001) (5)
- Hydrogen Bonding and Attenuation of the Rate of Enzymic Catalysis (1998) (4)
- Inactivation of the catalytic subunit of bovine cAMP‐dependent protein kinase by a peptide‐based affinity inactivator (1990) (4)
- Discovery of a potent picolinamide antibacterial active against Clostridioides difficile. (2020) (4)
- Selection and Characterization of b-Lactam – b-Lactamase Inactivator-Resistant Mutants following PCR Mutagenesis of the TEM-1 b-Lactamase Gene (1998) (4)
- A Structural Dissection of the Active Site of the Lytic Transglycosylase MltE from Escherichia coli. (2018) (4)
- Antibiotics as physiological stress inducers and bacterial response to the challenge. (2012) (4)
- The β-Lactam Antibiotics: Their Future in the Face of Resistance (2014) (4)
- Properties of analogues of an intermediate in the process of mechanism-based inactivation of carboxypeptidase A. (1996) (4)
- B -lactamases And Resistance To B-lactam Antibiotics (2001) (4)
- Bacterial Cell Wall (2015) (4)
- Evidence for a new enzyme-catalyzed reaction other than .beta.-lactam hydrolysis in turnover of a penem by the TEM-1 .beta.-lactamase (1993) (4)
- Horizontal-Acquisition of a Promiscuous Peptidoglycan-Recycling Enzyme Enables Aphids To Influence Symbiont Cell Wall Metabolism (2021) (3)
- Susceptibility of Methicillin-Resistant Staphylococcus aureus to Five Quinazolinone Antibacterials (2019) (3)
- Bacterial Cell Wall: Morphology and Biochemistry (3)
- MMP-1 and ADAM10 as Targets for Therapeutic Intervention in Idiopathic Pulmonary Fibrosis. (2022) (3)
- Facile Chloride Substitution of Activated Alcohols by Triphosgene: Application to Cephalosporin Chemistry. (1992) (3)
- Prospects of therapies targeting resistant bacteria-New challenges 20 years post emergence of vancomycin-resistant enterococcus. (2007) (3)
- Production of Proteins of the SARS-CoV-2 Proteome for Drug Discovery (2021) (3)
- Mechanistic support for the stepwise process for inactivation of class A β-lactamases by clavulanate (1995) (3)
- Synthesis and shift-reagent-assisted full NMR assignment of bacterial (Z8,E2,ω)-undecaprenol. (2017) (3)
- In Search of Selectivity in Inhibition of ADAM10. (2018) (3)
- The use of neamine as a molecular template: identification of active site residues in the bacterial antibiotic resistance enzyme aminoglycoside 3'-phosphotransferase type IIa by mass spectroscopy. (1998) (3)
- Crystal Structure of an Outer Membrane-Anchored Endolytic Peptidoglycan Lytic Transglycosylase (MltE) from Escherichia coli (2011) (3)
- Fluorescence Assessment of the AmpR-Signaling Network of Pseudomonas aeruginosa to Exposure to β-Lactam Antibiotics. (2020) (3)
- An Atypical ABC Transporter Is Involved in Antifungal Resistance and Host Interactions in the Pathogenic Fungus Cryptococcus neoformans (2022) (3)
- Structure-activity relationship of the cinnamamide family of antibiotic potentiators for methicillin-resistant Staphylococcus aureus (MRSA). (2018) (3)
- A Convenient Triphosgene‐Mediated Synthesis of Symmetric Carboxylic Acid Anhydrides. (1994) (3)
- Chapter 10:Thiirane Class of Gelatinase Inhibitors as a Privileged Template that Crosses the Blood–Brain Barrier (2015) (2)
- Crystal Structures of Bacterial (2011) (2)
- A NEW APPROACH TO THE PREPARATION OF N-CARBOXY α-AMINO ACID ANHYDRIDES (1985) (2)
- Facile preparation of a highly functionalized tetrahydropyran by catalytic hydrogenation of an oxazoline. (2008) (2)
- Integrative structural biology of the penicillin-binding protein-1 from Staphylococcus aureus, an essential component of the divisome machinery (2021) (2)
- Insertion of Epicatechin Gallate into the Cytoplasmic Membrane of Methicillin-resistantStaphylococcus aureus Disrupts Penicillin-binding Protein (PBP) 2a-mediated (2010) (2)
- Faculty Opinions recommendation of Total synthesis of Escherichia coli with a recoded genome. (2019) (2)
- Key side products due to reactivity of dimethylmaleoyl moiety as amine protective group (2009) (2)
- 6-(Hydroxyalkyl)penicillanates as Probes for Mechanisms of β-Lactamases. (2001) (2)
- Synthetic Efforts in Preparations of Components of the Bacterial Cell Wall (2008) (2)
- Side reaction of significance in preparation of peptide- or peptidomimetic-based hydroxamate enzyme inhibitors. (2006) (2)
- Exploration of mild copper-mediated coupling of organotrifluoroborates in the synthesis of thiirane-based inhibitors of matrix metalloproteinases. (2011) (2)
- Binding of Antibiotics to the Aminoacyl-Trna Site of Bacterial Ribosome (2007) (2)
- Inhibition of Class A β-Lactamases (2007) (2)
- Methoxycarbonylsulfamoyl)triethylammonium Hydroxide (2008) (2)
- Matrix Metalloproteinase 2 ( MMP 2 ) Inhibition : DFT and QM / MM Studies of the Deprotonation-Initialized Ring-Opening Reaction of the Sulfoxide Analogue of SB-3 CT (2010) (2)
- Medicinal Chemistry of β‐Lactam Antibiotics (2021) (2)
- Crystal structure of Penicillin-Binding Protein 6 (PBP6) from E. coli in apo state (2009) (1)
- Inhibition of human prostate cancer growth and osteolysis in a bone metastasis model by a mechanism-based specific gelatinase inhibitor (SB-3CT) (2005) (1)
- 1 Substrate Hydrolysis by Matrix Metalloproteinase-9 (2001) (1)
- Structural and Mechanistic Aspects of Evolution of β-Lactamases and Penicillin-Binding Proteins (1999) (1)
- Structure-based inhibitor design for reshaping bacterial morphology (2022) (1)
- Bis(trichloromethyl) Carbonate (2006) (1)
- Complex biological processes and their central chemical events. (2003) (1)
- Pharmacological Stabilization of Intracranial Aneurysms in Mice (2012) (1)
- Inhibition of MMP-9 by a selective gelatinase inhibitor protects neurovasculature from embolic focal cerebral ischemia (2012) (1)
- Matrix Metalloproteinase-14 as an Instigator of Fibrosis in Human Pterygium and Its Pharmacological Intervention. (2022) (1)
- Turnover Chemistry and Structural Characterization of the Cj0843c Lytic Transglycosylase of Campylobacter jejuni. (2021) (1)
- 6-(hydroxyalkyl)penicillanates as probes for mechanisms of beta-lactamases. (2000) (1)
- Strategies for Circumventing Bacterial Resistance Mechanisms (2014) (1)
- Structural basis of the Escherichi coli outer-membrane permeability (1999) (1)
- The Use of Neamine as a Molecular Template: Inactivation of Bacterial Antibiotic Resistance Enzyme Aminoglycoside 3′-Phosphotransferase Type IIa. (1999) (1)
- OXA 10 class D beta-lactamase at pH 6.0 (2001) (1)
- Proteomics Identification of Targets for Intervention in Pressure Ulcers. (2022) (1)
- N-(tert-Butoxycarbonyloxy)-5-norbornene-endo-2,3-dicarboximide, a Reagent for the Regioselective Introduction of the tert-Butoxycarbonyl (BOC) Protective Group at Unhindered Amines: Application to Aminoglycoside Chemistry. (2010) (1)
- Enantiomers of a selective gelatinase inhibitor: (R)- and (S)-2-[(4-phenoxyphenyl)sulfonylmethyl]thiirane. (2014) (1)
- A rational approach for the design of mechanism-based inactivators for zinc proteases (1994) (1)
- Denitrogenation of shale oil by oxime formation from pyrroles (1998) (1)
- A positive positive to negative (2018) (1)
- 1-(t-Butoxycarbonyl)imidazole (2001) (1)
- Metabolism of the Selective Matrix Metalloproteinase-9 Inhibitor (R)-ND-336. (2021) (1)
- Antibacterials: Volume II (2018) (1)
- Sulfonylation‐Induced N‐ to O‐Acetyl Migration in 2‐Acetamidoethanol Derivatives. (2010) (1)
- A Renaissance of Interest in Amino Glycoside Antibiotics (2001) (1)
- Crystal structure of Penicillin-Binding Protein 6 (PBP6) from E. coli in complex with a substrate fragment (2009) (0)
- Meropenem acylated BlaR1 sensor domain from Staphylococcus aureus (2011) (0)
- Faculty Opinions recommendation of Mechanistic Insights into β-Lactamase-Catalysed Carbapenem Degradation Through Product Characterisation. (2020) (0)
- Synthesis of Muramyl-δ-Lactam in Spore Peptidoglycan of Clostridioides difficile. (2023) (0)
- A-site RNA in complex with neamine (2006) (0)
- Faculty Opinions recommendation of From coarse to fine: the absolute Escherichia coli proteome under diverse growth conditions. (2021) (0)
- Faculty Opinions recommendation of Microplate-based surface area assay for rapid phenotypic antibiotic susceptibility testing. (2019) (0)
- CRYSTAL STRUCTURE OF CHOLINE BINDING PROTEIN F FROM STREPTOCOCCUS PNEUMONIAE IN THE PRESENCE OF A PEPTIDOGLYCAN ANALOGUE (TETRASACCHARIDE-PENTAPEPTIDE) (2009) (0)
- High-resolution crystal structure of an outer membrane-anchored endolytic peptidoglycan lytic transglycosylase (MltE) fromEscherichia coli (2011) (0)
- Synthetic Strategies for Regioselective Structural Modifications of Multifunctional Amino Glycoside Antibiotics (1999) (0)
- Penetration through Outer Membrane and Efflux Potential in Pseudomonas aeruginosa of Bulgecin A as an Adjuvant to β-Lactam Antibiotics (2023) (0)
- Crystal structure of TEM-76 beta-lactamase at 1.4 Angstrom resolution (2005) (0)
- OXA-10 class D beta-lactamase partially acylated with reacted 6beta-(1-hydroxy-1-methylethyl) penicillanic acid (2001) (0)
- Penicillin-Binding Protein 5 of Escherichia coli (2013) (0)
- Mechanism of the Escherichia coli MltE lytic transglycosylase, the cell-wall-penetrating enzyme for Type VI secretion system assembly (2018) (0)
- OXA 10 class D beta-lactamase at pH 6.5 (2001) (0)
- MAD structure of OXA10 class D beta-lactamase (2001) (0)
- Erratum (1974) (0)
- Crystal structure of NagZ from Pseudomonas aeruginosa in complex with N-acetylglucosamine (2017) (0)
- β-Lactams from the Ocean (2023) (0)
- Faculty Opinions recommendation of Promysalin Elicits Species-Selective Inhibition of Pseudomonas aeruginosa by Targeting Succinate Dehydrogenase. (2018) (0)
- Crystal structure of AmpDh2 from Pseudomonas aeruginosa in complex with pentapeptide (2013) (0)
- Faculty Opinions recommendation of Genetically Encoded Quinone Methides Enabling Rapid, Site-Specific, and Photocontrolled Protein Modification with Amine Reagents. (2021) (0)
- Structure of a Penicillin Binding Protein Complexed with a Cephalosporin-Peptidoglycan Mimic (2002) (0)
- Faculty Opinions recommendation of Implementation of permeation rules leads to a FabI inhibitor with activity against Gram-negative pathogens. (2020) (0)
- CRYSTAL STRUCTURE OF THE IMIPENEM INHIBITED TEM-1 BETA-LACTAMASE FROM ESCHERICHIA COLI (1999) (0)
- Faculty Opinions recommendation of A broad-spectrum antibiotic adjuvant reverses multidrug-resistant Gram-negative pathogens. (2020) (0)
- Collagen-mediated Signaling Receptor Tyrosine Kinases in Discoidin Domain Receptors : Unique Minireviews : (2013) (0)
- Matrix metalloproteinase proteolysis after stroke : a surrogate indicator for early diagnosis and validation of treatment (2010) (0)
- 1‐N‐(t‐Butoxycarbonyl)‐1H‐benzotriazole 3‐N‐Oxide (2001) (0)
- A mechanism-based inactivation study of neutral endopeptidase 24.11. [Erratum to document cited in CA119(13):134114z] (1993) (0)
- crystal structure of AmpD holoenzyme (2011) (0)
- Regioselective Control of the SNAr Amination of 5‐Substituted‐2,4‐dichloropyrimidines Using Tertiary Amine Nucleophiles. (2015) (0)
- Faculty Opinions recommendation of A Staphylococcus pro-apoptotic peptide induces acute exacerbation of pulmonary fibrosis. (2020) (0)
- crystal structure of AmpD in complex with reaction products (2011) (0)
- Crystal structure of AmpDh2 from Pseudomonas aeruginosa in complex with NAG-NAM-NAG-NAM tetrasaccharide (2013) (0)
- Faculty Opinions recommendation of Bio-Orthogonal Chemistry and Reloadable Biomaterial Enable Local Activation of Antibiotic Prodrugs and Enhance Treatments against Staphylococcus aureus Infections. (2019) (0)
- Faculty Opinions recommendation of Engineering bromodomains with a photoactive amino acid by engaging 'Privileged' tRNA synthetases. (2021) (0)
- A Novel Approach to Deacylation of Ceph-3-em Esters. (1986) (0)
- Crystal structure of NagZ H174A mutant from Pseudomonas aeruginosa (2017) (0)
- Matrix metalloproteinase inhibitors (2001) (0)
- CBAP-acylated BlaR1 sensor domain from Staphylococcus aureus (2011) (0)
- Resistance -Lactam β Penicillin-Binding Protein 5 in Pseudomonas aeruginosa Structural Analysis of the Role of (2014) (0)
- Stereoselective Reduction of α‐Bromopenicillanates by Tributylphosphine. (2001) (0)
- New Antibiotics For The Post‐Antibiotic Era (2016) (0)
- Erratum: A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia (Journal of Neuroscience (July 6, 2005) (6401-6408)) (2005) (0)
- Aminoglycoside 2 Reaction as a Point of Distinction among Source of Phosphate in the Enzymic Enzyme Catalysis and Regulation (2009) (0)
- Novel and Selective Inactivators for Matrix Metalloproteases Involved in Breast Cancer Metastasis (1998) (0)
- Turnover chemistry and structural characterization of the Cj0843c lytic transglycosylase of Campylobacter jejuni (2021) (0)
- Crystal structure of Zn-containing NagZ H174A mutant from Pseudomonas aeruginosa (2017) (0)
- Crystal structure of NagZ from Pseudomonas aeruginosa in complex with N-acetylglucosamine and L-Ala-1,6-anhydroMurNAc (2017) (0)
- Turapov 2015 supplemental material figures revised (2015) (0)
- Crystal structure of NagZ from Pseudomonas aeruginosa (2017) (0)
- Structural basis of the peptidoglycan binding to LytA, the major pneumococcal autolysin (2015) (0)
- Crystal structure of NagZ H174A mutant from Pseudomonas aeruginosa in complex with the inhibitor 2-acetamido-1,2-dideoxynojirimycin (2017) (0)
- Structure of Helicobacter pylori Csd3 from the hexagonal crystal (2015) (0)
- Monitoring 1-Lactamase Activity In Vivo by 13C Nuclear Magnetic Resonance Spectroscopy (0)
- Structure of OXA10 beta-lactamase at pH 8.3 (2001) (0)
- Asite RNA + designer antibiotic (2006) (0)
- Inhibition of beta-lactamases by 6,6-bis(hydroxylmethyl)penicillanate. (2001) (0)
- 1‐t‐Butoxycarbonyl‐1,2,4‐triazole (2001) (0)
- Crystal structure of Penicillin-Binding Protein 6 (PBP6) from E. coli in acyl-enzyme complex with ampicillin (2009) (0)
- Extracellular Proteases as Targets for Treatment of Cancer Metatases (2005) (0)
- The Type VI Secretion System of Pseudomonas aeruginosa Delivers a Cell-Wall Amidase to Target Bacterial Competitors (2019) (0)
- Beta-Lactam-Sensor Domain of BlaR1 (Apo) from Staphylococcus Aureus with Carboxylated Lys392 (2011) (0)
- Molecular Mechanism of Peptidoglycan Recognition by OmpA in Gram-negative Bacteria (2012) (0)
- AD Award Number : DAMD 1797-1-7174 TITLE : Novel and Selective Inactivators for Matrix . Metalloproteases Involved in Breast Cancer Metastasis (0)
- Faculty Opinions recommendation of Specific fluorescence labeling of target proteins by using a ligand-4-azidophthalimide conjugate. (2018) (0)
- Faculty Opinions recommendation of Vancomycin-Arginine Conjugate Inhibits Growth of Carbapenem-Resistant E. coli and Targets Cell-Wall Synthesis. (2020) (0)
- Antibacterials: Volume I (2018) (0)
- 6ALPHA-(HYDROXYPROPYL)PENICILLANATE ACYLATED ON NMC-A BETA-LACTAMASE FROM ENTEROBACTER CLOACAE (1998) (0)
- Faculty Opinions recommendation of Structural and mechanistic analysis of a β-glycoside phosphorylase identified by screening a metagenomic library. (2018) (0)
- Glyoxylyl Chloride p‐Toluenesulfonylhydrazone (2009) (0)
- Monitoring β-Lactamase Activity In Vivo by 13C Nuclear Magnetic Resonance Spectroscopy (1988) (0)
- Application of 2D-ITC to the Elucidation of the Enzymatic Mechanism of N-Acetylmuramic Acid/N-Acetylglucosamine Kinase (AmgK) from Pseudomonas aeruginosa. (2023) (0)
- CRYSTAL STRUCTURE OF STREPTOMYCES R61 DD-PEPTIDASE COMPLEXED WITH A NOVEL CEPHALOSPORIN ANALOG OF CELL WALL PEPTIDOGLYCAN (2001) (0)
- Structural analysis of the tripeptide-bound form of Helicobacter pylori Csd4, a D,L-carboxypeptidase (2014) (0)
- In vitro studies of the protein-interaction network of cell-wall lytic transglycosylase RlpA of Pseudomonas aeruginosa (2022) (0)
- 30S ribosome + designer antibiotic (2006) (0)
- aureusstant Staphylococcus to Oxadiazole Antibiotics in Stress Stimulon Contribute to Resistance and in the Cell Wall mmpL Mutations in (2014) (0)
- Structure of Lytic Transglycosylase MltC from Escherichia coli in complex with tetrasaccharide at 2.9 A resolution. (2014) (0)
- Synthetic Efforts in Preparation of Components of the Bacterial Cell Wall (2009) (0)
- OXA 10 class D beta-lactamase at pH 7.5 (2001) (0)
- crystal structure of Se-Met AmpD derivative (2011) (0)
- 715. Bulgecin A lowers Imipenem MICs in Clinical MDR Acinetobacter baumannii (ACB) Strains (2019) (0)
- Erratum to “The sentinel role of peptidoglycan recycling in the β-lactam resistance of the Gram-negative Enterobacteriaceae and Pseudomonas aeruginosa” [Bioorg. Chem. 56C (2014) 41–48] (2014) (0)
- Mechanism-based Inhibitor of Matrix Metalloproteinase-9 Rescues Brain from Focal Cerebral Ischemia-induced Damage and Improve Neurological Outcomes in Mice [abstract] (2010) (0)
- Crystal structure of the acylated beta-lactam sensor domain of Blar1 from S. aureus (2004) (0)
- Structure of Lytic Transglycosylase MltC from Escherichia coli at 2.3 A resolution. (2014) (0)
- crystal structure of AmpD grown at pH 5.5 (2011) (0)
- Crystal structure of Penicillin-Binding Protein 5 (PBP5) from Pseudomonas aeruginosa in apo state (2013) (0)
- Antibacterials as wonder drugs and how their effectiveness is being compromised (2002) (0)
- Structural analysis of the mDAP-bound form of Helicobacter pylori Csd4, a D,L-carboxypeptidase (2014) (0)
- Structure-Activity Relationship for the Picolinamide Antibacterials that Selectively Target Clostridioides difficile. (2021) (0)
- Crystal Structure of the complex between Q120L/Y150E mutant of AmpC and a beta-lactam inhibitor (MXG) (2003) (0)
- Structure of Helicobacter pylori Csd3 from the orthorhombic crystal (2015) (0)
- 2007 Foundation Host-Guest Chemistry of the Peptidoglycan (2011) (0)
- Faculty Opinions recommendation of Compound Uptake into E. coli Can Be Facilitated by N-Alkyl Guanidiniums and Pyridiniums. (2021) (0)
- 6 ALPHA HYDROXYMETHYL PENICILLOIC ACID ACYLATED ON THE TEM-1 BETA-LACTAMASE FROM ESCHERICHIA COLI (1997) (0)
- Targeting extracellular matrix remodeling sensitizes glioblastoma to ionizing radiation (2022) (0)
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