Shane Crotty | Academic Influence

Shane Crotty's AcademicInfluence.com Rankings

Shane Crotty

Biology

#3515

World Rank

#5367

Historical Rank

#1417

USA Rank

Virology

#76

World Rank

#79

Historical Rank

#26

USA Rank

Immunology

#153

World Rank

#161

Historical Rank

#50

USA Rank

biology Degrees

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Biology

Shane Crotty's Degrees

PhD Immunology University of California, San Francisco
Bachelors Biology University of California, San Diego

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Why Is Shane Crotty Influential?

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According to Wikipedia, Shane Patrick Crotty is a professor of immunology in the Center for Infectious Disease and Vaccine Research at La Jolla Institute for Immunology. Education and academic posts Crotty completed B.S. degrees in Biology and Writing from Massachusetts Institute of Technology in 1996. He then completed his Ph.D. in 2001 at the University of California, San Francisco with Raul Andino.

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Shane Crotty's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals (2020) (2848)
Follicular helper CD4 T cells (TFH). (2011) (2483)
Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection (2021) (1934)
Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation (2009) (1440)
T follicular helper cell differentiation, function, and roles in disease. (2014) (1368)
Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity (2020) (1215)
Adaptive immunity to SARS-CoV-2 and COVID-19 (2021) (1040)
Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans (2020) (899)
ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6. (2011) (856)
RNA virus error catastrophe: Direct molecular test by using ribavirin (2001) (810)
The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen (2000) (802)
Human circulating PD-1+CXCR3-CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses. (2013) (747)
T Follicular Helper Cell Biology: A Decade of Discovery and Diseases. (2019) (699)
Cutting Edge: Long-Term B Cell Memory in Humans after Smallpox Vaccination 1 (2003) (650)
Resolution of a chronic viral infection after interleukin-10 receptor blockade (2006) (574)
Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation (2010) (510)
IL-21 and IL-6 Are Critical for Different Aspects of B Cell Immunity and Redundantly Induce Optimal Follicular Helper CD4 T Cell (Tfh) Differentiation (2011) (500)
The transcription factor NFAT promotes exhaustion of activated CD8⁺ T cells. (2015) (465)
STAT5 is a potent negative regulator of TFH cell differentiation (2012) (445)
Tracking human antigen-specific memory B cells: a sensitive and generalized ELISPOT system. (2004) (440)
SAP is required for generating long-term humoral immunity (2003) (436)
A brief history of T cell help to B cells (2015) (431)
Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen (1999) (404)
Profiling the humoral immune response to infection by using proteome microarrays: high-throughput vaccine and diagnostic antigen discovery. (2005) (400)
Germinal Center T Follicular Helper Cell IL-4 Production Is Dependent on Signaling Lymphocytic Activation Molecule Receptor (CD150) (2010) (398)
A Blueprint for HIV Vaccine Discovery. (2012) (372)
Impact of SARS-CoV-2 variants on the total CD4+ and CD8+ T cell reactivity in infected or vaccinated individuals (2021) (369)
Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumors (2017) (367)
Inadequate T follicular cell help impairs B cell immunity during HIV infection (2013) (357)
SARS-CoV-2 vaccination induces immunological T cell memory able to cross-recognize variants from Alpha to Omicron (2022) (353)
Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen (1999) (336)
HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen (2016) (333)
Pre-existing immunity to SARS-CoV-2: the knowns and unknowns (2020) (319)
Bcl6 and Maf Cooperate To Instruct Human Follicular Helper CD4 T Cell Differentiation (2012) (304)
Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes (2015) (301)
In Vivo Regulation of Bcl6 and T Follicular Helper Cell Development (2010) (283)
Cutting Edge: STAT1 Is Required for IL-6–Mediated Bcl6 Induction for Early Follicular Helper Cell Differentiation (2013) (270)
Comprehensive analysis of T cell immunodominance and immunoprevalence of SARS-CoV-2 epitopes in COVID-19 cases (2020) (261)
Immunological memory in humans. (2004) (245)
CXCL13 is a plasma biomarker of germinal center activity (2016) (240)
Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches (2017) (236)
Dengue virus infection elicits highly polarized CX3CR1+ cytotoxic CD4+ T cells associated with protective immunity (2015) (233)
Ribavirin's antiviral mechanism of action: lethal mutagenesis? (2002) (230)
Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination (2016) (227)
Immunity and immunological memory following smallpox vaccination (2006) (224)
LEF-1 and TCF-1 orchestrate TFH differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6 (2015) (220)
Broadly Neutralizing Antibody Responses in a Large Longitudinal Sub-Saharan HIV Primary Infection Cohort (2016) (215)
Precursor Frequency and Affinity Determine B Cell Competitive Fitness in Germinal Centers, Tested with Germline‐Targeting HIV Vaccine Immunogens (2018) (212)
Vaccinia Virus H3L Envelope Protein Is a Major Target of Neutralizing Antibodies in Humans and Elicits Protection against Lethal Challenge in Mice (2005) (207)
Cross-reactive memory T cells and herd immunity to SARS-CoV-2 (2020) (207)
Bcl6 Expressing Follicular Helper CD4 T Cells Are Fate Committed Early and Have the Capacity To Form Memory (2013) (207)
Comprehensive analysis of T cell immunodominance and immunoprevalence of SARS-CoV-2 epitopes in COVID-19 cases (2021) (200)
BCL6 orchestrates Tfh cell differentiation via multiple distinct mechanisms (2015) (192)
Selective CD4+ T cell help for antibody responses to a large viral pathogen: deterministic linkage of specificities. (2008) (182)
Comparative analysis of activation induced marker (AIM) assays for sensitive identification of antigen-specific CD4 T cells (2017) (174)
A Cytokine-Independent Approach To Identify Antigen-Specific Human Germinal Center T Follicular Helper Cells and Rare Antigen-Specific CD4+ T Cells in Blood (2016) (173)
SARS-CoV-2 human T cell epitopes: Adaptive immune response against COVID-19 (2021) (164)
Negligible impact of SARS-CoV-2 variants on CD4+ and CD8+ T cell reactivity in COVID-19 exposed donors and vaccinees. (2021) (159)
Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance (2019) (159)
SAP regulates T cell–mediated help for humoral immunity by a mechanism distinct from cytokine regulation (2006) (158)
Hybrid immunity (2021) (157)
Low-dose mRNA-1273 COVID-19 vaccine generates durable memory enhanced by cross-reactive T cells (2021) (156)
Immunological memory to SARS-CoV-2 assessed for up to eight months after infection (2020) (152)
The receptor Ly108 functions as a SAP adaptor-dependent on-off switch for T cell help to B cells and NKT cell development. (2012) (145)
A distinct subpopulation of CD25− T-follicular regulatory cells localizes in the germinal centers (2017) (139)
Proteome‐wide analysis of the serological response to vaccinia and smallpox (2007) (139)
Direct Probing of Germinal Center Responses Reveals Immunological Features and Bottlenecks for Neutralizing Antibody Responses to HIV Env Trimer. (2016) (138)
Epigenetic landscapes reveal transcription factors regulating CD8+ T cell differentiation (2017) (137)
A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses (2019) (136)
Tfh cells and HIV bnAbs, an immunodominance model of the HIV neutralizing antibody generation problem (2017) (133)
Immune responses to Bacillus anthracis protective antigen in patients with bioterrorism-related cutaneous or inhalation anthrax. (2004) (131)
Murine Antibody Responses to Cleaved Soluble HIV-1 Envelope Trimers Are Highly Restricted in Specificity (2015) (125)
Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers (2019) (118)
Cytokine-Independent Detection of Antigen-Specific Germinal Center T Follicular Helper Cells in Immunized Nonhuman Primates Using a Live Cell Activation-Induced Marker Technique (2016) (113)
Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding (2017) (109)
SAP Regulation of Follicular Helper CD4 T Cell Development and Humoral Immunity Is Independent of SLAM and Fyn Kinase1 (2007) (108)
Apolipoprotein AI prevents regulatory to follicular helper T cell switching during atherosclerosis (2018) (104)
Engineered immunogen binding to alum adjuvant enhances humoral immunity (2020) (104)
The Transcription Factor Runx3 Establishes Chromatin Accessibility of cis-Regulatory Landscapes that Drive Memory Cytotoxic T Lymphocyte Formation. (2018) (103)
Protection against Simian Immunodeficiency Virus Vaginal Challenge by Using Sabin Poliovirus Vectors (2001) (103)
Vaccinia Virus-Specific CD4+ T Cell Responses Target a Set of Antigens Largely Distinct from Those Targeted by CD8+ T Cell Responses1 (2007) (103)
Vaccinia Virus Extracellular Enveloped Virion Neutralization In Vitro and Protection In Vivo Depend on Complement (2008) (102)
Poliovirus RNA-dependent RNA Polymerase (3Dpol) (2000) (101)
The E3 ubiquitin ligase Itch is required for the differentiation of follicular helper T cells (2014) (101)
NKT cells prevent chronic joint inflammation after infection with Borrelia burgdorferi (2008) (100)
Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance (2018) (99)
Harnessing CD4+ T cell responses in HIV vaccine development (2013) (98)
The transcription factor Foxp1 is a critical negative regulator of the differentiation of follicular helper T cells (2014) (98)
Monkeypox-Induced Immunity and Failure of Childhood Smallpox Vaccination To Provide Complete Protection (2007) (95)
SARS-CoV-2 infection generates tissue-localized immunological memory in humans (2021) (94)
Activin A programs the differentiation of human TFH cells (2016) (94)
Quantitative PCR technique for detecting lymphocytic choriomeningitis virus in vivo. (2008) (94)
Implications of high RNA virus mutation rates: lethal mutagenesis and the antiviral drug ribavirin. (2002) (93)
Dynamic regulation of Bcl6 in follicular helper CD4 T (Tfh) cells. (2013) (92)
In vivo RNA interference screens identify regulators of antiviral CD4(+) and CD8(+) T cell differentiation. (2014) (92)
Multifaceted Effects of Antigen Valency on B Cell Response Composition and Differentiation In Vivo (2020) (91)
The human naive B cell repertoire contains distinct subclasses for a germline-targeting HIV-1 vaccine immunogen (2018) (90)
Inhibition of NK cell activity by IL-17 allows vaccinia virus to induce severe skin lesions in a mouse model of eczema vaccinatum (2009) (89)
Humoral and cellular immune memory to four COVID-19 vaccines (2022) (87)
Epitopes for neutralizing antibodies induced by HIV-1 envelope glycoprotein BG505 SOSIP trimers in rabbits and macaques (2018) (86)
OX40 Drives Protective Vaccinia Virus-Specific CD8 T Cells12 (2008) (84)
Redundancy and Plasticity of Neutralizing Antibody Responses Are Cornerstone Attributes of the Human Immune Response to the Smallpox Vaccine (2008) (84)
Mucosal Immunization of Cynomolgus Macaques with Two Serotypes of Live Poliovirus Vectors Expressing Simian Immunodeficiency Virus Antigens: Stimulation of Humoral, Mucosal, and Cellular Immunity (1999) (82)
Omicron spike function and neutralizing activity elicited by a comprehensive panel of vaccines (2022) (81)
Humoral and cellular immune memory to four COVID-19 vaccines (2022) (79)
Germinal center enhancement by extended antigen availability. (2017) (77)
Th1/Th17 polarization persists following whole-cell pertussis vaccination despite repeated acellular boosters (2018) (76)
Poliovirus pathogenesis in a new poliovirus receptor transgenic mouse model: age-dependent paralysis and a mucosal route of infection. (2002) (76)
B Cell-Specific Expression of B7-2 Is Required for Follicular Th Cell Function in Response to Vaccinia Virus (2011) (73)
Reversible Reprogramming of Circulating Memory T Follicular Helper Cell Function during Chronic HIV Infection (2015) (70)
Recurrent group A Streptococcus tonsillitis is an immunosusceptibility disease involving antibody deficiency and aberrant TFH cells (2019) (69)
Th1 versus Th2 T cell polarization by whole-cell and acellular childhood pertussis vaccines persists upon re-immunization in adolescence and adulthood. (2016) (66)
Uncovering the interplay between CD8, CD4 and antibody responses to complex pathogens. (2010) (66)
Id2 reinforces TH1 cell differentiation and inhibits E2A to repress TFH cell differentiation (2016) (66)
Adjuvanting a Simian Immunodeficiency Virus Vaccine with Toll-Like Receptor Ligands Encapsulated in Nanoparticles Induces Persistent Antibody Responses and Enhanced Protection in TRIM5α Restrictive Macaques (2016) (66)
Correlates of protection against SARS‐CoV‐2 infection and COVID‐19 disease (2022) (66)
LEF-1 and TCF-1 orchestrate T follicular helper cell differentiation by regulating differentiation circuits upstream of Bcl6 (2015) (65)
OX40 Facilitates Control of a Persistent Virus Infection (2012) (65)
3M-052, a synthetic TLR-7/8 agonist, induces durable HIV-1 envelope–specific plasma cells and humoral immunity in nonhuman primates (2020) (64)
SARS-CoV-2 vaccination induces immunological memory able to cross-recognize variants from Alpha to Omicron (2021) (61)
Using a combined computational-experimental approach to predict antibody-specific B cell epitopes. (2014) (58)
Immunological memory to SARS‐CoV‐2 infection and COVID‐19 vaccines (2022) (57)
Hypogammaglobulinemia and exacerbated CD8 T-cell-mediated immunopathology in SAP-deficient mice with chronic LCMV infection mimics human XLP disease. (2006) (56)
Heavily Isotype-Dependent Protective Activities of Human Antibodies against Vaccinia Virus Extracellular Virion Antigen B5 (2009) (55)
Ly9 (CD229)-Deficient Mice Exhibit T Cell Defects yet Do Not Share Several Phenotypic Characteristics Associated with SLAM- and SAP-Deficient Mice1 (2006) (55)
The Poliovirus Replication Machinery Can Escape Inhibition by an Antiviral Drug That Targets a Host Cell Protein (2004) (55)
Increased peripheral blood neutrophil activation phenotypes and NETosis in critically ill COVID-19 patients: a case series and review of the literature (2021) (54)
Cutting Edge: NFAT Transcription Factors Promote the Generation of Follicular Helper T Cells in Response to Acute Viral Infection (2016) (54)
Combination therapy of vaccinia virus infection with human anti-H3 and anti-B5 monoclonal antibodies in a small animal model (2010) (51)
Ly9 (CD229)-deficient mice exhibit T cell defects yet do not share several phenotypic characteristics associated with SLAM- and SAP-deficient mice. (2006) (50)
Bcl6-Mediated Transcriptional Regulation of Follicular Helper T cells (TFH). (2021) (49)
BALDR: a computational pipeline for paired heavy and light chain immunoglobulin reconstruction in single-cell RNA-seq data (2018) (49)
Bcl-6 is the nexus transcription factor of T follicular helper cells (TFH) via repressor-of-repressor circuits (2020) (47)
Definition of Human Epitopes Recognized in Tetanus Toxoid and Development of an Assay Strategy to Detect Ex Vivo Tetanus CD4+ T Cell Responses (2017) (47)
Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b (2018) (46)
When designing vaccines, consider the starting material: the human B cell repertoire (2018) (46)
A TRAF-like motif of the inducible costimulator ICOS controls development of germinal center TFH cells via the kinase TBK1 (2016) (46)
T cells control the generation of nanomolar-affinity anti-glycan antibodies (2017) (46)
Differential T-Cell Reactivity to Endemic Coronaviruses and SARS-CoV-2 in Community and Health Care Workers (2021) (46)
Definition of epitopes and antigens recognized by vaccinia specific immune responses: their conservation in variola virus sequences, and use as a model system to study complex pathogens. (2009) (45)
Dances with cytokines, featuring TFH cells, IL-21, IL-4 and B cells (2016) (45)
Ezh2 programs TFH differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf (2018) (44)
Factors in B cell competition and immunodominance (2020) (43)
Modulation of SAP dependent T:B cell interactions as a strategy to improve vaccination. (2013) (41)
Chronic Lymphocytic Choriomeningitis Virus Infection Actively Down-Regulates CD4+ T Cell Responses Directed against a Broad Range of Epitopes1 (2007) (40)
Optimal Replication of Poliovirus within Cells (2005) (40)
Do Memory CD4 T Cells Keep Their Cell-Type Programming: Plasticity versus Fate Commitment? Complexities of Interpretation due to the Heterogeneity of Memory CD4 T Cells, Including T Follicular Helper Cells. (2018) (38)
Early Lymphoid Responses and Germinal Center Formation Correlate with Lower Viral Load Set Points and Better Prognosis of Simian Immunodeficiency Virus Infection (2014) (37)
Allergen-specific immunotherapy modulates the balance of circulating Tfh and Tfr cells. (2017) (35)
Exogenous OX40 Stimulation during Lymphocytic Choriomeningitis Virus Infection Impairs Follicular Th Cell Differentiation and Diverts CD4 T Cells into the Effector Lineage by Upregulating Blimp-1 (2013) (35)
Activin A programs human TFH cell differentiation (2016) (35)
Poliovirus vaccine strains as mucosal vaccine vectors and their potential use to develop an AIDS vaccine. (2004) (35)
Altering the context of an RNA bulge switches the binding specificities of two viral Tat proteins. (1998) (35)
Rapid Germinal Center and Antibody Responses in Non-human Primates after a Single Nanoparticle Vaccine Immunization (2019) (33)
The smallpox vaccine induces an early neutralizing IgM response. (2009) (33)
Structural and Biochemical Characterization of the Vaccinia Virus Envelope Protein D8 and Its Recognition by the Antibody LA5 (2012) (33)
Potent Neutralization of Vaccinia Virus by Divergent Murine Antibodies Targeting a Common Site of Vulnerability in L1 Protein (2014) (33)
tovirus-infected non-haematopoietic cells requires presentation of exogenous antigen (1999) (32)
Omicron BA.1 and BA.2 neutralizing activity elicited by a comprehensive panel of human vaccines (2022) (30)
B cells expressing authentic naive human VRC01-class BCRs can be recruited to germinal centers and affinity mature in multiple independent mouse models (2020) (30)
Structural and Functional Characterization of Anti-A33 Antibodies Reveal a Potent Cross-Species Orthopoxviruses Neutralizer (2015) (29)
Low dose mRNA-1273 COVID-19 vaccine generates durable T cell memory and antibodies enhanced by pre-existing crossreactive T cell memory (2021) (28)
Cutting Edge: T Follicular Helper Cell Differentiation Is Defective in the Absence of Bcl6 BTB Repressor Domain Function (2015) (28)
From perception to public policy: translating social constructions into policy designs (2005) (27)
Unusual Features of Vaccinia Virus Extracellular Virion Form Neutralization Resistance Revealed in Human Antibody Responses to the Smallpox Vaccine (2012) (27)
Bcl6 middle domain repressor function is required for T follicular helper cell differentiation and utilizes the corepressor MTA3 (2015) (26)
Manganese-Dependent Polioviruses Caused by Mutations within the Viral Polymerase (2003) (26)
Modulating the quantity of HIV Env-specific CD4 T cell help promotes rare B cell responses in germinal centers (2020) (24)
AI-guided discovery of the invariant host response to viral pandemics (2020) (24)
A particulate saponin/TLR agonist vaccine adjuvant alters lymph flow and modulates adaptive immunity (2021) (24)
Normal human lymph node T follicular helper cells and germinal center B cells accessed via fine needle aspirations (2019) (23)
Vaccine genetics of IGHV1-2 VRC01-class broadly neutralizing antibody precursor naïve human B cells (2021) (20)
An epitope conserved in orthopoxvirus A13 envelope protein is the target of neutralizing and protective antibodies (2011) (20)
Polyfunctional CD4+ T cell responses to a set of pathogenic arenaviruses provide broad population coverage (2010) (20)
In vivo RNAi screens: concepts and applications. (2015) (20)
Correction: Definition of Human Epitopes Recognized in Tetanus Toxoid and Development of an Assay Strategy to Detect Ex Vivo Tetanus CD4+ T Cell Responses (2017) (19)
Targeting HIV Env immunogens to B cell follicles in nonhuman primates through immune complex or protein nanoparticle formulations (2020) (18)
HIV vaccinology: 2021 update. (2021) (18)
Murine Anti-vaccinia Virus D8 Antibodies Target Different Epitopes and Differ in Their Ability to Block D8 Binding to CS-E (2014) (17)
Protection of Rabbits and Immunodeficient Mice against Lethal Poxvirus Infections by Human Monoclonal Antibodies (2012) (17)
Vaccination induces HIV broadly neutralizing antibody precursors in humans (2022) (17)
Chronic E-Cigarette Aerosol Inhalation Alters the Immune State of the Lungs and Increases ACE2 Expression, Raising Concern for Altered Response and Susceptibility to SARS-CoV-2 (2021) (17)
Linear Epitopes in Vaccinia Virus A27 Are Targets of Protective Antibodies Induced by Vaccination against Smallpox (2016) (17)
CRISPR-Mediated Slamf1Δ/Δ Slamf5Δ/Δ Slamf6Δ/Δ Triple Gene Disruption Reveals NKT Cell Defects but Not T Follicular Helper Cell Defects (2016) (16)
AI-guided discovery of the invariant host response to viral pandemics (2021) (16)
Bromodomain protein BRD4 directs and sustains CD8 T cell differentiation during infection (2021) (16)
Reinvigorating NIH Grant Peer Review. (2020) (15)
Multiplexed CRISPR/CAS9‐mediated engineering of pre‐clinical mouse models bearing native human B cell receptors (2020) (14)
Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM (2021) (14)
Systems Biology Methods Applied to Blood and Tissue for a Comprehensive Analysis of Immune Response to Hepatitis B Vaccine in Adults (2020) (13)
Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques (2021) (13)
Long-primed germinal centres with enduring affinity maturation and clonal migration (2022) (13)
Targeting HIV Env immunogens to B cell follicles in nonhuman primates through immune complex or protein nanoparticle formulations (2020) (13)
A TRAF-like motif of ICOS controls development of germinal center T follicular helper cells via TBK1 (2016) (12)
CD4+ follicular helper-like T cells are key players in anti-tumor immunity (2020) (11)
Protective Murine and Human Monoclonal Antibodies against Eczema Vaccinatum (2011) (11)
Structure–function characterization of three human antibodies targeting the vaccinia virus adhesion molecule D8 (2017) (11)
Retroviral vector expression in TCR transgenic CD4⁺ T cells. (2015) (11)
SARS-CoV-2 spike conformation determines plasma neutralizing activity elicited by a wide panel of human vaccines (2022) (11)
Author Correction: Pre-existing immunity to SARS-CoV-2: the knowns and unknowns (2020) (10)
NVX-CoV2373 vaccination induces functional SARS-CoV-2–specific CD4+ and CD8+ T cell responses (2022) (10)
Erratum: CCL19-CCR7–dependent reverse transendothelial migration of myeloid cells clears Chlamydia muridarum from the arterial intima (2017) (10)
Development of a T cell-based immunodiagnostic system to effectively distinguish SARS-CoV-2 infection and COVID-19 vaccination status (2022) (10)
Innovative approaches to track lymph node germinal center responses to evaluate development of broadly neutralizing antibodies in human HIV vaccine trials. (2018) (9)
Long-lasting germinal center responses to a priming immunization with continuous proliferation and somatic mutation (2021) (9)
Erratum: Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours (2018) (8)
Antibody responses induced by SHIV infection are more focused than those induced by soluble native HIV-1 envelope trimers in non-human primates (2021) (8)
Increased peripheral blood neutrophil activation phenotypes and NETosis in critically ill COVID-19 patients (2021) (7)
OX 40 Drives Protective Vaccinia Virus-Specific CD 8 T Cells 1 , 2 (2008) (6)
Response to Comment on “A Cytokine-Independent Approach To Identify Antigen-Specific Human Germinal Center T Follicular Helper Cells and Rare Antigen-Specific CD4+ T Cells in Blood” (2016) (6)
From structure to sequence: Antibody discovery using cryoEM (2022) (5)
Vaccine genetics of IGHV1-2 VRC01-class broadly neutralizing antibody precursor naïve human B cells (2021) (5)
Observations and perspectives on adaptive immunity to SARS-CoV-2. (2022) (4)
Raging evolution of a B cell response to a viral infection (2018) (4)
B cells expressing authentic naive human VRC01-class BCRs can be primed and recruited to germinal centers in multiple independent mouse models (2020) (4)
Memory B-Cell Development After Asymptomatic or Mild Symptomatic SARS-CoV-2 Infection (2022) (4)
Erratum: Activin A programs the differentiation of human TFH cells (2016) (4)
Differential T cell reactivity to seasonal coronaviruses and SARS-CoV-2 in community and health care workers (2021) (4)
Bcl-6 is the nexus transcription factor of T follicular helper cells via repressor-of-repressor circuits (2020) (4)
Harnessing Activin A Adjuvanticity to Promote Antibody Responses to BG505 HIV Envelope Trimers (2020) (4)
Phosphate-mediated coanchoring of RBD immunogens and molecular adjuvants to alum potentiates humoral immunity against SARS-CoV-2 (2021) (4)
Immune memory and vaccines : great debates (2018) (3)
Author Correction: A Engineered immunogen binding to alum adjuvant enhances humoral immunity (2020) (3)
Development of host immune response to bacteriophage in a lung transplant recipient on adjunctive phage therapy for a multidrug resistant pneumonia. (2022) (3)
Erratum: Ly9 (CD229)-deficient mice exhibit T cell defects yet do not share several phenotypic characteristics associated with SLAM- and SAP-deficient mice (Journal of Immunology (2006) 176 (291-300)) (2006) (3)
Vaccine-induced protection from homologous Tier 2 simian-human immunodeficiency virus challenge in nonhuman primates (2018) (3)
Development of an animal model of progressive vaccinia in nu/nu mice and the use of bioluminescence imaging for assessment of the efficacy of monoclonal antibodies against vaccinial B5 and L1 proteins (2017) (2)
T Cell Responses to SARS-CoV-2. (2022) (2)
Revealing T follicular helper cells with BCL6 (2021) (2)
Profiling Transcription Initiation in Peripheral Leukocytes Reveals Severity-Associated Cis-Regulatory Elements in Critical COVID-19 (2021) (2)
Increased IL-8, Neutrophil Activation Phenotypes and NETosis in Critically Ill COVID-19 Patients (2020) (2)
Distinguishing COVID-19 infection and vaccination history by T cell reactivity (2021) (2)
Correction to: Increased Peripheral Blood Neutrophil Activation Phenotypes and Neutrophil Extracellular Trap Formation in Critically Ill Coronavirus Disease 2019 Patients: A Case Series and Review of the Literature (2022) (2)
Characterization of murine antibody responses to vaccinia virus envelope protein A14 reveals an immunodominant antigen lacking of effective neutralization targets. (2018) (2)
Recent Advances in Immunology That Impact Vaccine Development (2009) (2)
Shane Crotty: exploring immune memory. Interview by Kira Heller. (2009) (2)
Mucosal and systemic responses to SARS-CoV-2 vaccination in infection naïve and experienced individuals (2021) (2)
Editorial overview: Vaccine immunology: what is seen and not seen. (2019) (2)
Single-cell lineage trajectories and chromatin regulators that initialize antiviral CD8 T cell ontogeny (2021) (2)
Bcl 6 BTB Repressor Domain Function Differentiation Is Defective in the Absence of Cutting Edge : T Follicular Helper Cell (2015) (1)
Bamlanivimab therapy for acute COVID-19 does not blunt SARS-CoV-2–specific memory T cell responses (2022) (1)
Activation Molecule Receptor IL-4 Production Is Dependent on Signaling Germinal Center T Follicular Helper Cell (2010) (1)
Comprehensive analysis of Tcell immunodominance and immunoprevalence of SARS-CoV-2 epitopes in COVID-19 cases (2021) (1)
T cell independent B cell response to an RNA‐binding viral protein (Vaccinia E3) (2008) (1)
S-4: Differentiation and function of follicular helper T cells (Tfh) (2013) (1)
From Structure to Sequence: Identification of polyclonal antibody families using cryoEM (2021) (1)
Longitudinally Tracked, Rapid and Robust Antigen-Specific Germinal Center Responses in Non-Human Primates after a Single Nanoparticle Vaccine Immunization (2019) (1)
Highly mutated antibodies capable of neutralizing N276 glycan-deficient HIV after a single immunization with an Env trimer (2022) (1)
Complement dependence of vaccinia virus extracellular enveloped virion ( EV ) neutralization in vitro and protection in vivo (2008) (1)
Quantitative PCR (QPCR) technique for detecting lymphocytic choriomeningitis virus (LCMV) in vivo (2009) (1)
A role for inactivation of the Foxo1 transcription factor in the differentiation of T follicular helper cells (P1131) (2013) (1)
Highly Mutated Antibodies Capable of Neutralizing N276-Glycan Deficient HIV after a Single Immunization with an Env Trimer (2021) (1)
Observations and Perspectives on Adaptive Immunity to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) (2022) (1)
The persistence of memory: defining, engineering, and measuring vaccine durability (2022) (1)
miR-146a as a negative regulator in controlling humoral immunity (IRM10P.612) (2015) (1)
BCL6 Orchestrates Tfh Differentiation Via Multiple Distinct Mechanisms (2014) (1)
Virus-based vectors for gene expression in mammalian cells: Poliovirus (2003) (1)
pathogenic arenaviruses provide broad population coverage (2010) (1)
The Transcription Factor YY-1 Is an Essential Regulator of T Follicular Helper Cell Differentiation (2022) (1)
Exploration of roles of CD4 T cell help in recruitment of rare B cells to germinal centers (2020) (1)
Erratum: Inflammatory triggers associated with exacerbations of COPD orchestrate plasticity of group 2 innate lymphoid cells in the lungs (2016) (1)
Deterministic linkage between CD4 T cell and B cell specificities to a large virus: vaccinia virus (43.1) (2007) (1)
Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b (2018) (0)
Design and validation of HIV peptide pools for detection of HIV-specific CD4+ and CD8+ T cells (2022) (0)
Author Correction: Long-primed germinal centres with enduring affinity maturation and clonal migration (2023) (0)
Asymptomatic or symptomatic SARS-CoV-2 infection plus vaccination confers increased adaptive immunity to variants of concern (2022) (0)
Ezh2 programs TFH differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf (2018) (0)
Epigenetic targeting of Brd4 constrains CD8+ T cell differentiation during infection and cancer (2019) (0)
Identification of MLL1 as a novel regulator of Tfh cell differentiation (2020) (0)
Dynamic activity in cis-regulatory elements of leukocytes identifies transcription factor activation and stratifies COVID-19 severity in ICU patients (2023) (0)
Mixed Lineage Leukemia (Mll1) establishes global histone H3K4 trimethylation and stem like memory Cd8 T cell formation (2023) (0)
The Immunology of Recurrent Group A Streptococcus Tonsillitis (2017) (0)
Author Correction: A Engineered immunogen binding to alum adjuvant enhances humoral immunity (2020) (0)
ResearchPolyfunctional CD 4 + T cell responses to a set of pathogenic arenaviruses provide broad population coverage (2010) (0)
Resource Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches Graphical Abstract Highlights (0)
African Early Infection Cohort as a Platform for Vaccine Discovery: The IAVI Protocol C Experience (2014) (0)
Dynamic regulation of Bcl6 in follicular helper T cells, Tfh (2013) (0)
DNA architectural protein CTCF facilitates subset-specific chromatin interactions to limit the formation of memory CD8+ T cells. (2023) (0)
Acute and Post-Acute COVID-19 Outcomes Among Immunologically Naïve Adults During Delta Versus Omicron Waves (2022) (0)
SARS-CoV-2 human T cell epitopes: Adaptive immune response against COVID-19 (2022) (0)
Bromodomain protein BRD4 directs CD8 T cell differentiation during infection and cancer (2021) (0)
Bcl6 is the nexus transcription factor of T follicular helper cell (TFH) differentiation via a set of repressor-of-repressor gene circuits (2020) (0)
Selective CD4 T cell help for B cell and antibody responses to vaccinia (2008) (0)
Protection from vaccinia virus‐induced severe skin lesions by natural killer cells in a mouse model of eczema vaccinatum (2008) (0)
Mucosal and Systemic Responses to Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination Determined by Severity of Primary Infection (2022) (0)
Independent of SLAM and Fyn Kinase Cell Development and Humoral Immunity Is SAP Regulation of Follicular Helper CD4 T (2006) (0)
MLL1-COMPASS establishes developmental patterning of the memory CD8 T cell compartment and ensures regenerative immunity. (2021) (0)
Follicular Helper CD4 T Cell Differentiation Bcl6 and Maf Cooperate To Instruct Human (2012) (0)
Blimp-1the Effector Lineage by Upregulating Differentiation and Diverts CD4 T Cells into Infection Impairs Follicular Th Cell Lymphocytic Choriomeningitis Virus Exogenous OX40 Stimulation during (2013) (0)
SARS-CoV-2 vaccination induces T cell memory responses able to cross-recognize ongoing SARS-CoV-2 variants including omicron. (2022) (0)
Roles of Bcl6 and Blimp1 in CD4 T follicular helper (Tfh) lineage commitment (99.11) (2010) (0)
CD8 T Cells OX40 Drives Protective Vaccinia Virus-Specific (2011) (0)
Follicular helper CD4 T cell (T FH ) differentiation and their role in protective immunity (2010) (0)
miR-146a restricts germinal center B cell responses through targeting CD40 signaling pathway (2016) (0)
Mpox vaccine and infection-driven human immune signatures (2023) (0)
Apolipoprotein AI prevents regulatory to follicular helper T cell switching during atherosclerosis (2018) (0)
Title: Increased peripheral blood neutrophil activation phenotypes and NETosis in critically ill COVID-19 patients (2021) (0)
Structure Resource Using a Combined Computational-Experimental Approach to Predict Antibody-Specific B Cell Epitopes (2014) (0)
BALDR: a computational pipeline for paired heavy and light chain immunoglobulin reconstruction in single-cell RNA-seq data (2018) (0)
Engineered immunogen binding to alum adjuvant enhances humoral immunity (2020) (0)
This information is current as Activation-Induced Marker Technique Nonhuman Primates Using a Live Cell Follicular Helper Cells in Immunized Antigen-Specific Germinal Center T Cytokine-Independent Detection of Silvestri and (2016) (0)
the Capacity To Form Memory Cells Are Fate Committed Early and Have Bcl6 Expressing Follicular Helper CD4 T (2013) (0)
Virologist and published author Shane Crotty sees immune memory as the key to making a better vaccine. (2009) (0)
Humans after Smallpox Vaccination Cutting Edge: Long-Term B Cell Memory in (2003) (0)
Author Correction: The persistence of memory: defining, engineering, and measuring vaccine durability (2022) (0)
Acute and Postacute COVID-19 Outcomes Among Immunologically Naive Adults During Delta vs Omicron Waves (2023) (0)
Important roles for Fyn in CD4 T cell activation and helper functions in vivo (2008) (0)
Vaccinia Virus Follicular Th Cell Function in Response to B Cell-Specific Expression of B7-2 Is Required for (2011) (0)
Structural basis for antibody-mediated neutralization of Lymphocytic choriomeningitis virus (2022) (0)
How T-Cells Control Antibody Responses (2018) (0)
Human blood Tfh cells (P4534) (2013) (0)
Antigen valency dictates the affinity of B cells recruited to germinal centers and the magnitude of extrafollicular B cell responses (2020) (0)
Evidence that recurrent Group A streptococcus tonsillitis is an immunosusceptibility disease involving antibody deficiency and aberrant Tfh cells (2018) (0)
High levels of endemic coronaviruses reactive CD4+ T cells in SARS-CoV-2 seronegative health care workers (2021) (0)
THE HIV VACCINE PROBLEM : WHY HAVE PAST APPROACHES TO DEVELOP AN HIV VACCINE FAILED ? (0)
Range of Epitopes T Cell Responses Directed against a Broad + CD 4 Virus Infection Actively Down-Regulates Chronic Lymphocytic (2007) (0)
IL-2 secreting T helper cells promote EF B cell maturation via intrinsic regulation of B cell mTOR/AKT/Blimp-1 axis (2022) (0)
Ets1 governs the differential formation of circulating and tissue-resident memory CD8 T cells (2021) (0)
Understanding Leader-Member Exchange in International Contexts (2016) (0)
IL-2 Mediates Generalized Tfh Downregulation during Allergen-Specific Immunotherapy (2016) (0)
Identifying key transcriptional regulators that establish T cell memory during viral infection (2020) (0)
Human antibody responses to vaccinia virus D 8 1 Structure-function characterization of three human antibodies targeting the vaccinia virus adhesion molecule D 8 (2017) (0)
Diversity of neutralizing antibody responses in human smallpox vaccinees (2008) (0)
Mll1 pioneers histone H3K4me3 deposition and promotes formation of CD8+ T stem cell memory (2023) (0)
The transcription factor Mef2d regulates B:T synapse–dependent GC-TFH differentiation and IL-21–mediated humoral immunity (2023) (0)
Development of Follicular Helper T Cells (2014) (0)
Dengue virus infection elicits highly polarized CX3CR1+ cytotoxic CD4+ T cells associated with protective immunity (VIR1P.1126) (2015) (0)
STAT5 is a negative regulator of Bcl6-mediated TFH differentiation (63.2) (2011) (0)
POLIOVIRUS: AN INTERLUDE (2019) (0)
Johnston Follicular Helper Cell Differentiation Bcl 6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T (2014) (0)
Differences in T cell responses to Bordetella Pertussis in adults as a function of whole cell versus acellular childhood vaccination (2019) (0)
The Chromatin Regulator Mll1 Supports T Follicular Helper Cell Differentiation by Controlling Expression of Bcl6, LEF-1, and TCF-1. (2023) (0)
Germinal center reaction (WS-031) Chairpersons: Nobuo Sakaguchi, Garnett Kelsoe (2010) (0)
Pre-existing immunity to SARS-CoV-2: the knowns and unknowns (2020) (0)
Erratum: A TRAF-like motif of the inducible costimulator ICOS controls development of germinal center TFH cells via the kinase TBK1 (2016) (0)
Simian Immunodeficiency Virus Infection Viral Load Set Points and Better Prognosis of Center Formation Correlate with Lower Early Lymphoid Responses and Germinal (2014) (0)
Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding (2017) (0)

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