Sheldon Pinnell
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American dermatologist
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Why Is Sheldon Pinnell Influential?
(Suggest an Edit or Addition)According to Wikipedia, Sheldon R. Pinnell was an American dermatologist and physician-scientist who served as the J. Lamar Callaway Professor of Dermatology at Duke University. His research involves sun protection, photoaging, collagen chemistry, and topical percutaneous absorption of antioxidants. In 2013, he was made an honorary member of the Society of Investigative Dermatology.
Sheldon Pinnell's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Cutaneous photodamage, oxidative stress, and topical antioxidant protection. (2003) (489)
- Regulation of collagen synthesis by ascorbic acid. (1981) (465)
- The cross-linking of collagen and elastin: enzymatic conversion of lysine in peptide linkage to alpha-aminoadipic-delta-semialdehyde (allysine) by an extract from bone. (1968) (415)
- A heritable disorder of connective tissue. Hydroxylysine-deficient collagen disease. (1972) (367)
- Topical vitamin C protects porcine skin from ultraviolet radiation‐induced damage (1992) (330)
- Cross-linking of collagen and elastin. Properties of lysyl oxidase. (1970) (310)
- UV photoprotection by combination topical antioxidants vitamin C and vitamin E. (2003) (294)
- Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin. (2005) (259)
- Evidence supporting zinc as an important antioxidant for skin (2002) (252)
- The Ehlers-Danlos syndromes. (1993) (226)
- Ascorbic acid specifically increases type I and type III procollagen messenger RNA levels in human skin fibroblast. (1988) (205)
- Keloids: a review. (1981) (202)
- Effects of ascorbic acid on proliferation and collagen synthesis in relation to the donor age of human dermal fibroblasts. (1994) (184)
- Microfine zinc oxide (Z-cote) as a photostable UVA/UVB sunblock agent. (1999) (182)
- Effectiveness of antioxidants (vitamin C and E) with and without sunscreens as topical photoprotectants. (1996) (182)
- A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation. (2008) (173)
- Topical L‐Ascorbic Acid: Percutaneous Absorption Studies (2001) (173)
- Tranilast, a selective inhibitor of collagen synthesis in human skin fibroblasts. (1994) (152)
- Lysyl-protocollagen hydroxylase deficiency in fibroblasts from siblings with hydroxylysine-deficient collagen. (1972) (150)
- Protective effects of a topical antioxidant mixture containing vitamin C, ferulic acid, and phloretin against ultraviolet‐induced photodamage in human skin (2008) (132)
- Topical minoxidil in early male pattern baldness. (1985) (131)
- Urinary excretion of hydroxylysine and its glycosides as an index of collagen degradation. (1977) (124)
- Once-weekly fluconazole (150, 300, or 450 mg) in the treatment of distal subungual onychomycosis of the toenail. (1998) (122)
- Ehlers-Danlos syndrome type VI: clinical manifestations of collagen lysyl hydroxylase deficiency. (1989) (120)
- Topical vitamin C in aging. (1996) (116)
- Regulation of collagen biosynthesis by ascorbic acid: a review. (1985) (106)
- Regulation of collagen synthesis by ascorbic acid. Ascorbic acid increases type I procollagen mRNA. (1982) (100)
- A double-blind, randomized, prospective trial to evaluate topical vitamin C solution for the prevention of radiation dermatitis☆ (1993) (94)
- Altered collagen composition in a prolapsing mitral valve with ruptured chordae tendineae. (1979) (88)
- Ascorbic acid preferentially enhances type I and III collagen gene transcription in human skin fibroblasts. (1996) (88)
- Human collagens: differences in glycosylated hydroxylysines in skin and bone. (1971) (87)
- Vitamin C abrogates the deleterious effects of UVB radiation on cutaneous immunity by a mechanism that does not depend on TNF-alpha. (1997) (80)
- Collagen synthesis in cultured human skin fibroblasts: effect of ascorbic acid and its analogs. (1983) (77)
- Suppression of fibroblast proliferation and lysyl hydroxylase activity by minoxidil. (1987) (72)
- Ascorbic acid and transforming growth factor-β1 increase collagen biosynthesis via different mechanisms: Coordinate regulation of proα1(I) and proα1(III) collagens☆ (1992) (70)
- Regulation of collagen synthesis. (1982) (66)
- A patient with Ehlers-Danlos syndrome type VI is a compound heterozygote for mutations in the lysyl hydroxylase gene. (1994) (62)
- Collagen synthesis by human skin fibroblasts in culture: studies of fibroblasts explanted from papillary and reticular dermis. (1981) (61)
- Inherited human collagen lysyl hydroxylase deficiency: ascorbic acid response. (1978) (56)
- Modern approaches to photoprotection. (2000) (55)
- Ubiquinone, idebenone, and kinetin provide ineffective photoprotection to skin when compared to a topical antioxidant combination of vitamins C and E with ferulic acid. (2006) (55)
- Characterization of a partial cDNA for lysyl hydroxylase from human skin fibroblasts; lysyl hydroxylase mRNAs are regulated differently by minoxidil derivatives and hydralazine. (1992) (51)
- Regulation of lysyl oxidase mRNA in dermal fibroblasts from normal donors and patients with inherited connective tissue disorders. (1994) (48)
- Regulation of prolyl and lysyl hydroxylase activities in cultured human skin fibroblasts by ascorbic acid. (1981) (48)
- Desmosine Biosynthesis: Nature of Inhibition by D-Penicillamine (1968) (46)
- Procollagen I synthesis in human skin fibroblasts: effect on culture conditions on biosynthesis. (1980) (45)
- Generalized microsporum audoninii infection and depressed cellular immunity associated with a missing plasma factor required for lymphocyte blastogenesis. (1977) (41)
- Inhibition of collagen hydroxylation by lithospermic acid magnesium salt, a novel compound isolated from Salviae miltiorrhizae Radix. (1994) (40)
- A familial cutis laxa syndrome with ultrastructural abnormalities of collagen and elastin. (1980) (39)
- Pharmacokinetics of three doses of once-weekly fluconazole (150, 300, and 450 mg) in distal subungual onychomycosis of the toenail. (1998) (39)
- Calcofluor White Combination Antifungal Treatments for Trichophyton rubrum and Candida albicans (2012) (39)
- Investigation of the nature of the intermediates involved in desmosine biosynthesis. (1967) (38)
- Protection of Chinese hamster ovary cells from paraquat-mediated cytotoxicity by a low molecular weight mimic of superoxide dismutase (DF-Mn). (1988) (36)
- COMPARATIVE STUDY OF WOUND HEALING IN PORCINE SKIN WITH CO2 LASER AND OTHER SURGICAL MODALITIES: PRELIMINARY FINDINGS (1995) (35)
- Minoxidil stimulates elastin expression in aortic smooth muscle cells. (1994) (35)
- Ascorbic acid and collagen synthesis: rethinking a role for lipid peroxidation. (1993) (34)
- Hereditary C2 deficiency associated with cutaneous lupus erythematosus: clinical, laboratory, and genetic studies. (1979) (34)
- Prolyl and lysyl hydroxylase activities of human skin fibroblasts: effect of donor age and ascorbate. (1980) (31)
- Delayed healing in full-thickness wounds treated with aluminum chloride solution. A histologic study with evaporimetry correlation. (1986) (30)
- A substitution at a non-glycine position in the triple-helical domain of pro alpha 2(I) collagen chains present in an individual with a variant of the Marfan syndrome. (1990) (30)
- Isolation of type III collagen from human adult parenchymal lung tissue. (1977) (29)
- In vitro inhibition of chick embryo lysyl hydroxylase by homogentisic acid. A proposed connective tissue defect in alkaptonuria. (1977) (28)
- Sequence analysis of a cDNA for lysyl hydroxylase isolated from human skin fibroblasts from a normal donor: differences from human placental lysyl hydroxylase cDNA. (1994) (27)
- A double-blind, randomized, prospective trial to evaluate topical vitamin C solution for the prevention of radiation dermatitis. CNS Cancer Consortium. (1993) (25)
- Ichthyosis, mental retardation, and asymptomatic spasticity. A new neurocutaneous syndrome with normal fatty alcohol:NAD+ oxidoreductase activity. (1990) (25)
- Ascorbic acid and transforming growth factor-beta 1 increase collagen biosynthesis via different mechanisms: coordinate regulation of pro alpha 1(I) and Pro alpha 1(III) collagens. (1992) (25)
- A comparison of lysyl hydroxylation in various types of collagen from type VI Ehlers-Danlos syndrome fibroblasts. (1983) (23)
- Minimum structural requirements for minoxidil inhibition of lysyl hydroxylase in cultured fibroblasts. (1994) (23)
- Double-blind study of levamisole in aphthous stomatitis. (1978) (22)
- Effects of minoxidil on cultured human skin fibroblasts. (1987) (22)
- Low molecular weight L-chain components related to Bence-Jones proteins. (1966) (22)
- Clobetasol Propionate Versus Fluocinonide Creams in Psoriasis and Eczema (1985) (22)
- The structure and function of dermal connective tissue in normal individuals and patients with inherited connective tissue disorders. (1982) (21)
- The collagen of heart valve. (1977) (21)
- Clobetasol Propionate Versus Fluocinonide Creams in Psoriasis and Eczema (1985) (21)
- Serum stimulation of lysyl hydroxylase activity in cultured human skin fibroblasts. (1985) (20)
- The expression of a functional, secreted human lysyl hydroxylase in a baculovirus system. (1996) (19)
- Structure-activity relationship of minoxidil analogs as inhibitors of lysyl hydroxylase in cultured fibroblasts. (1992) (18)
- Degradation of porcine dermal connective tissue by collagenase and hyaluronidase (1986) (18)
- α-Lipoic Acid Is Ineffective as a Topical Antioxidant for Photoprotection of Skin1 (2004) (18)
- A 38 base pair insertion in the proα2(I) collagen gene of a patient with Marfan syndrome (1985) (17)
- Ascorbic acid stimulates collagen production without altering intracellular degradation in cultured human skin fibroblasts. (1986) (17)
- Molecular defects in the Ehlers-Danlos syndrome. (1982) (16)
- Hydralazine differentially increases mRNAs for the α and β subunits of prolyl 4-hydroxylase whereas it decreases proα1(I) collagen mRNAs in human skin fibroblasts (1991) (15)
- A common duplication in the lysyl hydroxylase gene of patients with Ehlers Danlos syndrome type VI results in preferential stimulation of lysyl hydroxylase activity and mRNA by hydralazine. (1997) (14)
- Construction of a Full-Length Murine Proα2(I) Collagen cDNA by the Polymerase Chain Reaction (1991) (13)
- Ascorbyl-6-palmitate is not ascorbic acid. (2002) (12)
- Isolation and Characterization of a Human Pro α2(I) Collagen Gene Segment (1984) (12)
- Alpha-lipoic acid is ineffective as a topical antioxidant for photoprotection of skin. (2004) (10)
- Inhibition of lysyl hydroxylase by catechol analogs. (1977) (10)
- A paradoxical effect of hydralazine on prolyl and lysyl hydroxylase activities in cultured human skin fibroblasts. (1985) (10)
- Studies on the inhibition of collagen synthesis in fibroblasts treated with paraquat. (1993) (10)
- LEVAMISOLE AND SKIN DISEASE (1978) (10)
- Mixed lymphocyte responses in a four-generation C2 deficiency family. (1977) (9)
- Abnormal collagens in connective tissue diseases. (1975) (9)
- THE BENEFITS OF TOPICAL VITAMIN C (L-ASCORBIC ACID) FOR SKIN CARE ANO UV PROTECTION (1999) (8)
- Regarding d-alpha-tocopherol. (1999) (8)
- Antioxidants can reverse the deleterious effects of ultraviolet B (UVB) radiation on cutaneous immunity. (1995) (7)
- Topical vitamin C in skin care. (1998) (7)
- Bioavailability of selenium from the selenotrisulphide derivative of lipoic acid (2006) (7)
- The mRNA and the activity of lysyl hydroxylase are up-regulated by the administration of ascorbate and hydralazine to human skin fibroblasts from a patient with Ehlers-Danlos syndrome type VI. (1995) (7)
- The skin in Ehlers-Danlos syndrome. (1987) (7)
- Hydralazine differentially increases mRNAs for the alpha and beta subunits of prolyl 4-hydroxylase whereas it decreases pro alpha 1(I) collagen mRNAs in human skin fibroblasts. (1991) (7)
- In vitro inhibition of collagen cross links by catechol analogs. (1977) (6)
- Connective tissue diseases. (1983) (5)
- Effects of minoxidil on human skin fibroblasts in culture. (1988) (5)
- Proceedings of 31st Annual Symposium on the Biology of Skin Structural Elements of the Dermis (1982) (5)
- Effectiveness of a combination of vitamins C and E in inhibiting UV damage to porcine skin (1993) (3)
- Normal and Mutant Human Collagen Genes (1985) (3)
- Lysyl oxidase the enzymatic step in collagen and elastin cross linking (1970) (3)
- Clinical and laboratory studies Topical minoxidil in early male pattern baldness (1985) (3)
- Keloids and hypertrophic scars. (1984) (2)
- Dermal fibroblasts from a subset of patients with ehlers danlos syndrome type VI exhibit and abnormally large 4.2-kb mRNA for lysyl hydroxylase (1994) (2)
- New and Improved Daily Photoprotection: Microfine Oxide (Z-Cote®) (1999) (2)
- Isolation and characterization of a human pro alpha 2(I) collagen gene segment. (1984) (2)
- Ehlers-Danlos syndrome type VI: manifestations of collagen lysyl hydroxylase deficiency Clinical (1989) (2)
- Using topical antioxidants to protect against photodamage and improve skin care (2001) (2)
- Levamisole and agrandulocytosis. (1979) (1)
- Microfine zinc oxide (Z-Cote®): A new broad spectrum sunscreen ingredient (1998) (1)
- Connective tissue disease: Molecular pathology of the extracellular matrix (The biochemistry of disease series, vol. 12) (1987) (1)
- Identification of the Target Genes of Atopic Dermatitis by Real-Time PCR (2006) (1)
- Lysyl hydroxylase exhibits reduced stimulation by ascorbate and hydralazine in dermal fibroblasts from a patient with Ehlers Danlos syndrome type VI compared with a normal donor (1994) (0)
- Contents, Vol. 175, Supplement 2, 1987 (1987) (0)
- A patient with ehlers danlos syndrome type VI is a compound heterozygote for the lysyl hydroxylase gene (1993) (0)
- A 38 base pair insertion in the pro alpha 2(I) collagen gene of a patient with Marfan syndrome. (1985) (0)
- Stable compositions of ascorbic acid (1990) (0)
- Clinical review Keloids: A review* (1981) (0)
- Topical vitamin C: A new photo-protectant (1998) (0)
- Construction of a full-length murine pro alpha 2(I) collagen cDNA by the polymerase chain reaction. (1991) (0)
- Collagen and Collagen Abnormalities (1988) (0)
- Compositions d'acide ascorbique stabilisees et methodes associees (2005) (0)
- Baculovirus expression confirms that deletion of cysteine 369 in lysyl hydroxylase (LH) results in loss of LH activity in two patients with Ehlers Danlos type VI (1998) (0)
- Ascorbic acid compositions stabilized and procedures therefor. (2005) (0)
- Compound heterozygosity for a nonsense mutations and an exon deletion in the lysyl hydroxylase gene of a patient with ehlers danlos syndrome type VI (1996) (0)
- Author Index/Subject Index (2021) (0)
- Cellecx-C®-Topical vitamin C solution* (1995) (0)
- A TOPICAL FORMULATION CONTAINING L-TYROSINE DOES NOT INTENSIFY PIGMENTATION IN HUMAN SKIN (1999) (0)
- Characterization of the regulatory and minoxidil-responsive elements in the 5′ flanking region of the lysyl hydroxylase gene (1998) (0)
- Structural analogs of pyridoxal benzoyl hydrazone with improved fibrosuppressive activity in cell culture (1998) (0)
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