Shigeo Ohno
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(Suggest an Edit or Addition)Shigeo Ohno's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The PAR-aPKC system: lessons in polarity (2006) (717)
- Protein Kinase C δ Activates the MEK-ERK Pathway in a Manner Independent of Ras and Dependent on Raf* (1996) (615)
- IgG1 plasmacytosis in interleukin 6 transgenic mice. (1989) (607)
- Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay. (2006) (579)
- An Atypical PKC Directly Associates and Colocalizes at the Epithelial Tight Junction with ASIP, a Mammalian Homologue of Caenorhabditis elegans Polarity Protein PAR-3 (1998) (544)
- A metalloprotease–disintegrin, MDC9/meltrin‐γ/ADAM9 and PKCδ are involved in TPA‐induced ectodomain shedding of membrane‐anchored heparin‐binding EGF‐like growth factor (1998) (527)
- Junctional adhesion molecules (JAMs): more molecules with dual functions? (2004) (508)
- Atypical Protein Kinase C Is Involved in the Evolutionarily Conserved Par Protein Complex and Plays a Critical Role in Establishing Epithelia-Specific Junctional Structures (2001) (468)
- Intercellular junctions and cellular polarity: the PAR-aPKC complex, a conserved core cassette playing fundamental roles in cell polarity. (2001) (458)
- Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity (2007) (453)
- Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cδ (2002) (426)
- Tissue-specific expression of three distinct types of rabbit protein kinase C (1987) (406)
- Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in Caenorhabditis elegans. (1998) (403)
- The cell polarity protein ASIP/PAR‐3 directly associates with junctional adhesion molecule (JAM) (2001) (398)
- Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay. (2001) (397)
- A phorbol ester receptor/protein kinase, nPKC eta, a new member of the protein kinase C family predominantly expressed in lung and skin. (1990) (394)
- PAR-6–PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1 (2005) (391)
- Mammalian Lgl Forms a Protein Complex with PAR-6 and aPKC Independently of PAR-3 to Regulate Epithelial Cell Polarity (2003) (378)
- Molecular cloning of a novel mammalian calcium-dependent protease distinct from both m- and mu-types. Specific expression of the mRNA in skeletal muscle. (1989) (360)
- Requirement of Atypical Protein Kinase Cλ for Insulin Stimulation of Glucose Uptake but Not for Akt Activation in 3T3-L1 Adipocytes (1998) (352)
- Polarity-Dependent Distribution of Angiomotin Localizes Hippo Signaling in Preimplantation Embryos (2013) (349)
- A novel phorbol ester receptor/protein kinase, nPKC, distantly related to the protein kinase C family (1988) (336)
- A new member of the protein kinase C family, nPKC theta, predominantly expressed in skeletal muscle (1992) (334)
- Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. (2003) (324)
- PAR‐6 regulates aPKC activity in a novel way and mediates cell‐cell contact‐induced formation of the epithelial junctional complex (2001) (323)
- aPKC Acts Upstream of PAR-1b in Both the Establishment and Maintenance of Mammalian Epithelial Polarity (2004) (323)
- Muscle Develops a Specific Form of Small Heat Shock Protein Complex Composed of MKBP/HSPB2 and HSPB3 during Myogenic Differentiation* (2000) (307)
- Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein. (1999) (288)
- Role of the PAR-3–KIF3 complex in the establishment of neuronal polarity (2004) (287)
- Evolutionary origin of a calcium-dependent protease by fusion of genes for a thiol protease and a calcium-binding protein? (1984) (282)
- EGF or PDGF receptors activate atypical PKClambda through phosphatidylinositol 3‐kinase. (1996) (278)
- Caveolin Interaction with Protein Kinase C (1997) (270)
- aPKC kinase activity is required for the asymmetric differentiation of the premature junctional complex during epithelial cell polarization (2002) (264)
- Tumor Necrosis Factor Signaling to Stress-activated Protein Kinase (SAPK)/Jun NH2-terminal Kinase (JNK) and p38 (1998) (251)
- Calcium‐activated neutral protease and its endogenous inhibitor Activation at the cell membrane and biological function (1987) (247)
- Two distinct cDNAs for human IMP dehydrogenase. (1990) (241)
- SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. (2009) (237)
- Generation of plasmacytomas with the chromosomal translocation t(12;15) in interleukin 6 transgenic mice. (1992) (237)
- Spatial regulation of VEGF receptor endocytosis in angiogenesis (2013) (233)
- The Mixed Lineage Kinase SPRK Phosphorylates and Activates the Stress-activated Protein Kinase Activator, SEK-1* (1996) (225)
- A Novel Integrin-Linked Kinase–Binding Protein, Affixin, Is Involved in the Early Stage of Cell–Substrate Interaction (2001) (222)
- Tumor promotion by depleting cells of protein kinase C delta (1997) (221)
- Differential activation of adenylyl cyclase by protein kinase C isoenzymes. (1994) (214)
- N- and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMD (2011) (212)
- Regulated protein–protein interaction between aPKC and PAR‐3 plays an essential role in the polarization of epithelial cells (2002) (204)
- MEK Kinase Is Involved in Tumor Necrosis Factor α-Induced NF-κB Activation and Degradation of IκB-α* (1996) (200)
- The nucleotide sequence of human fibroblast interferon cDNA. (1980) (196)
- c-Jun N-Terminal Kinase (JNK)-Interacting Protein-1b/Islet-Brain-1 Scaffolds Alzheimer's Amyloid Precursor Protein with JNK (2001) (195)
- Protein kinase C isotypes and their specific functions: prologue. (2002) (193)
- PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity. (2003) (186)
- Protein Kinase C δ Inhibits the Proliferation of Vascular Smooth Muscle Cells by Suppressing G1 Cyclin Expression* (1997) (185)
- Involvement of ASIP/PAR-3 in the promotion of epithelial tight junction formation. (2002) (181)
- MST/MLK2, a Member of the Mixed Lineage Kinase Family, Directly Phosphorylates and Activates SEK1, an Activator of c-Jun N-terminal Kinase/Stress-activated Protein Kinase* (1997) (178)
- Platelet-derived growth factor activates protein kinase C epsilon through redundant and independent signaling pathways involving phospholipase C gamma or phosphatidylinositol 3-kinase. (1996) (176)
- Inactivation of aPKCλ results in the loss of adherens junctions in neuroepithelial cells without affecting neurogenesis in mouse neocortex (2006) (176)
- The von Hippel-Lindau Tumor Suppressor Protein Mediates Ubiquitination of Activated Atypical Protein Kinase C* (2001) (169)
- Interaction between PAR-3 and the aPKC–PAR-6 complex is indispensable for apical domain development of epithelial cells (2009) (169)
- Delimitation and properties of DNA sequence: required for the regulated expression of human interferon-β gene (1985) (159)
- Asymmetric distribution of PAR proteins in the mouse embryo begins at the 8-cell stage during compaction. (2005) (153)
- Regulation of activity of calcium activated neutral protease. (1988) (150)
- MKBP, a Novel Member of the Small Heat Shock Protein Family, Binds and Activates the Myotonic Dystrophy Protein Kinase (1998) (146)
- Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C (2001) (144)
- AAA+ Proteins RUVBL1 and RUVBL2 Coordinate PIKK Activity and Function in Nonsense-Mediated mRNA Decay (2010) (143)
- The beta isoform of protein kinase C stimulates human melanogenesis by activating tyrosinase in pigment cells. (1993) (141)
- Involvement of IL-32 in activation-induced cell death in T cells. (2006) (139)
- Self-association of PAR-3-mediated by the Conserved N-terminal Domain Contributes to the Development of Epithelial Tight Junctions* (2003) (138)
- A point mutation at the putative ATP-binding site of protein kinase C alpha abolishes the kinase activity and renders it down-regulation-insensitive. A molecular link between autophosphorylation and down-regulation. (1990) (132)
- Transfection with protein kinase C alpha confers increased multidrug resistance to MCF-7 cells expressing P-glycoprotein. (1991) (131)
- Lgl mediates apical domain disassembly by suppressing the PAR-3-aPKC-PAR-6 complex to orient apical membrane polarity (2006) (130)
- Activation of the JNK pathway by distantly related protein kinases, MEKK and MUK. (1996) (130)
- Ras‐dependent signal transduction is indispensable but not sufficient for the activation of AP1/Jun by PKC delta. (1994) (126)
- An essential role of the aPKC–Aurora A–NDEL1 pathway in neurite elongation by modulation of microtubule dynamics (2009) (124)
- Protein Kinase C Regulates Integrin-induced Activation of the Extracellular Regulated Kinase Pathway Upstream of Shc* (1999) (123)
- The c-Jun N-Terminal Kinase Activator Dual Leucine Zipper Kinase Regulates Axon Growth and Neuronal Migration in the Developing Cerebral Cortex (2006) (123)
- Role of Lgl/Dlg/Scribble in the regulation of epithelial junction, polarity and growth. (2008) (122)
- Structural and functional diversities of a family of signal transducing protein kinases, protein kinase C family; two distinct classes of PKC, conventional cPKC and novel nPKC. (1991) (118)
- Association of ASIP/mPAR‐3 with adherens junctions of mouse neuroepithelial cells (2002) (114)
- PAR3 is essential for cyst-mediated epicardial development by establishing apical cortical domains (2006) (113)
- Tumor type-dependent function of the par3 polarity protein in skin tumorigenesis. (2012) (113)
- Complete amino acid sequence of the large subunit of the low‐Ca2+‐requiring form of human Ca2+‐activated neutral protease (μCANP) deduced from its cDNA sequence (1986) (112)
- Structure and expression of a cloned cDNA for mouse interferon-beta. (1983) (112)
- Expression of human IMP dehydrogenase types I and II in Escherichia coli and distribution in human normal lymphocytes and leukemic cell lines. (1991) (105)
- The Epithelial Circumferential Actin Belt Regulates YAP/TAZ through Nucleocytoplasmic Shuttling of Merlin. (2017) (104)
- Protein Kinase C λ/ι (PKCλ/ι): A PKC Isotype Essential for the Development of Multicellular Organisms (2003) (103)
- Direct interaction of the beta-domain of VHL tumor suppressor protein with the regulatory domain of atypical PKC isotypes. (1999) (101)
- Loss of von Hippel-Lindau protein causes cell density dependent deregulation of CyclinD1 expression through Hypoxia-inducible factor (2003) (99)
- The overexpression and altered localization of the atypical protein kinase C lambda/iota in breast cancer correlates with the pathologic type of these tumors. (2008) (98)
- Specificity of the high affinity interaction of protein kinase C with a physiological substrate, myristoylated alanine-rich protein kinase C substrate. (1994) (97)
- A distinct PAR complex associates physically with VE‐cadherin in vertebrate endothelial cells (2006) (95)
- Structure of a chromosomal gene for human interferon beta. (1981) (93)
- Inhibition of nonsense‐mediated mRNA decay rescues the phenotype in Ullrich's disease (2004) (93)
- Calcium activated neutral protease--structure-function relationship and functional implications. (1990) (93)
- Molecular cloning of a cDNA coding for human leukotriene A4 hydrolase. Complete primary structure of an enzyme involved in eicosanoid synthesis. (1987) (92)
- Specific inhibition of nonsense-mediated mRNA decay components, SMG-1 or Upf1, rescues the phenotype of Ullrich disease fibroblasts. (2006) (90)
- The role of SMG-1 in nonsense-mediated mRNA decay. (2005) (87)
- UCN‐01, an anti‐tumor drug, is a selective inhibitor of the conventional PKC subfamily (1995) (85)
- Expression and properties of two distinct classes of the phorbol ester receptor family, four conventional protein kinase C types, and a novel protein kinase C. (1990) (85)
- Primary structures of human protein kinase C βI and βII differ only in their C‐terminal sequences (1987) (85)
- Structure and properties of a ubiquitously expressed protein kinase C, nPKCδ (1991) (84)
- Protein kinase C lambda/iota (PKClambda/iota): a PKC isotype essential for the development of multicellular organisms. (2003) (84)
- MAPK-upstream protein kinase (MUK) regulates the radial migration of immature neurons in telencephalon of mouse embryo. (2002) (83)
- The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8. (2011) (82)
- Structures of SMG1-UPFs complexes: SMG1 contributes to regulate UPF2-dependent activation of UPF1 in NMD. (2014) (80)
- Primary Structure of a γ Subunit of G Protein, γ12, and Its Phosphorylation by Protein Kinase C * (1995) (80)
- Presenilin 1 Suppresses the Function of C-Jun Homodimers via Interaction with Qm/Jif-1 (1999) (78)
- Atypical protein kinase Clambda binds and regulates p70 S6 kinase. (1998) (77)
- Affixin interacts with α-actinin and mediates integrin signaling for reorganization of F-actin induced by initial cell–substrate interaction (2004) (77)
- A Protein Kinase Cδ-binding Protein SRBC Whose Expression Is Induced by Serum Starvation* (1997) (76)
- Overexpression of a beta-galactoside binding protein causes transformation of BALB3T3 fibroblast cells. (1991) (76)
- PKCλ regulates glucose-induced insulin secretion through modulation of gene expression in pancreatic β cells (2005) (75)
- Oral Ingestion of Collagen Hydrolysate Leads to the Transportation of Highly Concentrated Gly-Pro-Hyp and Its Hydrolyzed Form of Pro-Hyp into the Bloodstream and Skin. (2017) (75)
- Activation of novel protein kinases C delta and C epsilon upon mitogenic stimulation of quiescent rat 3Y1 fibroblasts. (1994) (75)
- ASPP2 Regulates Epithelial Cell Polarity through the PAR Complex (2010) (74)
- The androgen insensitive mouse: absence of intranuclear androgen retention in the kidney. (1971) (73)
- Differential targeting of protein kinase C and CaM kinase II signalings to vimentin (1995) (73)
- Nucleotide sequence of chick 14K β-galactoside-binding lectin mRNA (1986) (72)
- Differentiation-associated localization of nPKC eta, a Ca(++)-independent protein kinase C, in normal human skin and skin diseases. (1993) (72)
- aPKCλ/ι promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6 (2009) (71)
- Function of Atypical Protein Kinase C λ in Differentiating Photoreceptors Is Required for Proper Lamination of Mouse Retina (2005) (71)
- Conventional protein kinase C (PKC)‐α and novel PKCε, but not ‐δ, increase the secretion of an N‐terminal fragment of Alzheimer's disease amyloid precursor protein from PKC cDNA transfected 3Y1 fibroblasts (1995) (71)
- Cholesterol sulfate, a novel activator for the eta isoform of protein kinase C. (1994) (70)
- Functional divergence of protein kinase C (PKC) family members. PKC gamma differs from PKC alpha and -beta II and nPKC epsilon in its competence to mediate-12-O-tetradecanoyl phorbol 13-acetate (TPA)-responsive transcriptional activation through a TPA-response element. (1993) (70)
- An Essential Role of the Universal Polarity Protein, aPKCλ, on the Maintenance of Podocyte Slit Diaphragms (2009) (70)
- Enzymatic properties of a novel phorbol ester receptor/protein kinase, nPKC. (1989) (69)
- KIBRA Suppresses Apical Exocytosis through Inhibition of aPKC Kinase Activity in Epithelial Cells (2011) (69)
- Hyperosmolality induces activation of cPKC and nPKC, a requirement for ERK1/2 activation in NIH/3T3 cells. (2000) (67)
- Overproduction of a Ca(2+)-independent protein kinase C isozyme, nPKC epsilon, increases the secretion of prolactin from thyrotropin-releasing hormone-stimulated rat pituitary GH4C1 cells. (1994) (65)
- Axon Formation in Neocortical Neurons Depends on Stage-Specific Regulation of Microtubule Stability by the Dual Leucine Zipper Kinase–c-Jun N-Terminal Kinase Pathway (2011) (65)
- A carboxy-terminal deletion mutant of protein kinase C beta II inhibits insulin-stimulated 2-deoxyglucose uptake in L6 rat skeletal muscle cells. (1996) (63)
- The Isoform of Protein Kinase C Mediates Transcriptional Activation of the Human Transglutaminase 1 Gene (*) (1996) (63)
- Protein Kinase Cα Plays a Critical Role in Mannosylerythritol Lipid-induced Differentiation of Melanoma B16 Cells* (2001) (62)
- Behavior of tight-junction, adherens-junction and cell polarity proteins during HNF-4alpha-induced epithelial polarization. (2005) (62)
- Interaction of Nck-associated protein 1 with activated GTP-binding protein Rac. (1997) (62)
- A fourth type of rabbit protein kinase C. (1988) (61)
- Purification and characterization of protein kinase C epsilon from rabbit brain. (1992) (61)
- Four genes for the calpain family locate on four distinct human chromosomes. (1990) (60)
- Translocation of HSP27 and MKBP in ischemic heart. (1999) (57)
- Inducer-responsive expression of the cloned human interferon beta 1 gene introduced into cultured mouse cells. (1982) (57)
- The first CH domain of affixin activates Cdc42 and Rac1 through αPIX, a Cdc42/Rac1‐specific guanine nucleotide exchanging factor (2004) (56)
- The eta isoform of protein kinase C is localized on rough endoplasmic reticulum (1994) (54)
- Differential Activation of Two JNK Activators, MKK7 and SEK1, by MKN28-derived Nonreceptor Serine/Threonine Kinase/Mixed Lineage Kinase 2* (1998) (54)
- Tandemly reiterated negative enhancer-like elements regulate transcription of a human gene for the large subunit of calcium-dependent protease. (1989) (52)
- Polarity-Regulating Kinase Partitioning-Defective 1/Microtubule Affinity-Regulating Kinase 2 Negatively Regulates Development of Dendrites on Hippocampal Neurons (2007) (52)
- Gene structure of calcium‐dependent protease retains the ancestral organization of the calcium‐binding protein gene (1986) (52)
- Characterization of SMG-9, an essential component of the nonsense-mediated mRNA decay SMG1C complex (2010) (52)
- Direct Binding of Lgl2 to LGN during Mitosis and Its Requirement for Normal Cell Division* (2005) (51)
- Expression of MUK/DLK/ZPK, an activator of the JNK pathway, in the nervous systems of the developing mouse embryo. (2005) (51)
- The inhibition of differentiation caused by TGFbeta in fetal myoblasts is dependent upon selective expression of PKCtheta: a possible molecular basis for myoblast diversification during limb histogenesis. (1996) (50)
- Protein kinase C beta 1 and protein kinase C beta 2 activate p57 mitogen-activated protein kinase and block differentiation in colon carcinoma cells. (1996) (49)
- Differential induction of protein kinase C isoforms at the cardiac hypertrophy stage and congestive heart failure stage in Dahl salt-sensitive rats. (2003) (49)
- High Expression of Atypical Protein Kinase C λ/ι in Gastric Cancer as a Prognostic Factor for Recurrence (2009) (49)
- A New Protein Kinase C, nPKCη′, and nPCKθ Are Expressed in Human Platelets: Involvement of nPKCη′ and nPKCθ in Signal Transduction Stimulated by PAF (1993) (49)
- Possible role of Ca2+-independent protein kinase C isozyme, nPKCɛ, in thyrotropin- releasing hormone-stimulated signal transduction: Differential down-regulation of nPKCɛ in GH4C1 cells* (1990) (48)
- Adipocytes but Not for Akt Activation in 3 T 3L 1 for Insulin Stimulation of Glucose Uptake λ Requirement of Atypical Protein Kinase C (1998) (47)
- Rabbit brain glucose transporter responds to insulin when expressed in insulin-sensitive Chinese hamster ovary cells. (1989) (46)
- Distant N- and C-terminal Domains Are Required for Intrinsic Kinase Activity of SMG-1, a Critical Component of Nonsense-mediated mRNA Decay* (2007) (46)
- Tumor suppressor protein VHL is induced at high cell density and mediates contact inhibition of cell growth (2001) (45)
- Unique expression pattern of protein kinase C‐θ: high mRNA levels in normal mouse testes and in T‐lymphocytic cells and neoplasms (1993) (45)
- Cloning and characterization of the T‐box gene Tbx6 in Xenopus laevis (2001) (45)
- The 8th and 9th tandem spectrin-like repeats of utrophin cooperatively form a functional unit to interact with polarity-regulating kinase PAR-1b. (2010) (45)
- Heat shock protein 90 regulates phosphatidylinositol 3‐kinase‐related protein kinase family proteins together with the RUVBL1/2 and Tel2‐containing co‐factor complex (2012) (43)
- A Novel Role for hSMG-1 in Stress Granule Formation (2011) (43)
- Molecular cloning and sequencing of cDNA for rat cathepsin H Homology in pro‐peptide regions of cysteine proteinases (1987) (43)
- Meiotic maturation induces animal-vegetal asymmetric distribution of aPKC and ASIP/PAR-3 in Xenopus oocytes. (2000) (43)
- Staurosporine‐related compounds, K252a and UCN‐01, inhibit both cPKC and nPKC (1993) (42)
- Possible role of ILK-affixin complex in integrin-cytoskeleton linkage during platelet aggregation. (2002) (42)
- Regulation of expression and activity of four PKC isozymes in confluent and mechanically stimulated UMR‐108 osteoblastic cells (2001) (42)
- aPKC enables development of zonula adherens by antagonizing centripetal contraction of the circumferential actomyosin cables (2008) (42)
- Role of PKC isoforms in glucose transport in 3T3-L1 adipocytes: insignificance of atypical PKC. (2002) (41)
- Role of protein kinase C in the modulation of multidrug resistance: expression of the atypical gamma isoform of protein kinase C does not confer increased resistance to doxorubicin. (1992) (41)
- The 14‐3‐3 protein binds its target proteins with a common site located towards the C‐terminus (1997) (41)
- Calcium-Activated Neutral Protease (CANP) and its Biological and Medical Implications (1987) (40)
- Dynamic changes in protein components of the tight junction during liver regeneration (2001) (40)
- The 5'-flanking sequence of human interferon-beta 1 gene is responsible for viral induction of transcription. (1983) (39)
- Regulation of Asymmetric Division and CD8+ T Lymphocyte Fate Specification by Protein Kinase Cζ and Protein Kinase Cλ/ι (2015) (39)
- Intracellular polarity protein PAR‐1 regulates extracellular laminin assembly by regulating the dystroglycan complex (2009) (38)
- Integrated regulation of PIKK-mediated stress responses by AAA+ proteins RUVBL1 and RUVBL2 (2012) (38)
- A cell polarity protein aPKCλ is required for eye lens formation and growth (2009) (38)
- Transient up-regulation of myotonic dystrophy protein kinase-binding protein, MKBP, and HSP27 in the neonatal myocardium. (1999) (38)
- Regulation of epithelial cell polarity by PAR-3 depends on Girdin transcription and Girdin–Gαi3 signaling (2015) (38)
- Inhibition of Insulin-induced Glucose Uptake by Atypical Protein Kinase C Isotype-specific Interacting Protein in 3T3-L1 Adipocytes* (2000) (37)
- Cholesterol sulfate, an activator of protein kinase C mediating squamous cell differentiation: a review. (2000) (37)
- A domain containing the Cdc42/Rac interactive binding (CRIB) region of p65PAK inhibits transcriptional activation and cell transformation mediated by the Ras‐Rac pathway (1997) (37)
- Nucleotide exchange factor ECT2 regulates epithelial cell polarity. (2006) (37)
- The phosphorylation of HIV-1 Gag by atypical protein kinase C facilitates viral infectivity by promoting Vpr incorporation into virions (2014) (36)
- YSK1, a novel mammalian protein kinase structurally related to Ste20 and SPS1, but is not involved in the known MAPK pathways (1997) (34)
- Protein kinase C is involved in 24‐hydroxylase gene expression induced by 1,25(OH)2D3 in rat intestinal epithelial cells (1994) (34)
- Wortmannin inhibits the activation of MAP kinase following vasopressin V1 receptor stimulation (1995) (33)
- Translation-dependent unwinding of stem–loops by UPF1 licenses Regnase-1 to degrade inflammatory mRNAs (2019) (33)
- Opposite effects of the overexpression of protein kinase C gamma and delta on the growth properties of human glioma cell line U251 MG. (1994) (32)
- MTCL1 crosslinks and stabilizes non-centrosomal microtubules on the Golgi membrane (2014) (32)
- A Protein Kinase C Isozyme, NPKC-ϵ, Is Involved in the Activation of NF-κ-B by 12-O-Tetradecanoylphorbol-13-Acetate (TPA) in Rat 3Y1 Fibroblasts (1995) (32)
- The novel PAR-1-binding protein MTCL1 has crucial roles in organizing microtubules in polarizing epithelial cells (2013) (31)
- aPKC restricts the basolateral determinant PtdIns(3,4,5)P3 to the basal region. (2008) (30)
- MEK kinase is involved in tumor necrosis factor alpha-induced NF-kappaB activation and degradation of IkappaB-alpha. (1996) (30)
- Human cytomegalovirus IE1 protein activates AP-1 through a cellular protein kinase(s). (1999) (30)
- aPKCλ maintains the integrity of the glomerular slit diaphragm through trafficking of nephrin to the cell surface (2014) (29)
- Maintenance of Dendritic Spine Morphology by Partitioning-Defective 1b through Regulation of Microtubule Growth (2011) (29)
- PKClambda regulates glucose-induced insulin secretion through modulation of gene expression in pancreatic beta cells. (2005) (29)
- Differential Effects of Overexpression of PKCα and PKCδ/ϵ on Cellular E2F Activity in Late G1 Phase (1996) (29)
- Expression of human leukotriene A4 hydrolase cDNA in Escherichia coli (1988) (28)
- Inhibition of SMG-8, a subunit of SMG-1 kinase, ameliorates nonsense-mediated mRNA decay-exacerbated mutant phenotypes without cytotoxicity (2013) (28)
- Loss of partitioning-defective-3/isotype-specific interacting protein (par-3/ASIP) in the elongating spermatid of RA175 (IGSF4A/SynCAM)-deficient mice. (2007) (28)
- Over‐expression of PAR‐3 suppresses contact‐mediated inhibition of cell migration in MDCK cells (2002) (27)
- Phosphoinositide binding by par-3 involved in par-3 localization. (2011) (27)
- Stimulatory antibody-induced activation and selective translocation of protein kinase C isoenzymes in human platelets. (1995) (26)
- Intracellular Localization of the Ret Finger Protein Depends on a Functional Nuclear Export Signal and Protein Kinase C Activation* (2001) (25)
- Conventional protein kinase C (PKC)-alpha and novel PKC epsilon, but not -delta, increase the secretion of an N-terminal fragment of Alzheimer's disease amyloid precursor protein from PKC cDNA transfected 3Y1 fibroblasts. (1995) (25)
- PAR-1/MARK: a kinase essential for maintaining the dynamic state of microtubules. (2012) (25)
- The γ-Parvin-Integrin-Linked Kinase Complex Is Critically Involved in Leukocyte-Substrate Interaction1 (2006) (25)
- PAR‐3 controls endothelial planar polarity and vascular inflammation under laminar flow (2018) (24)
- Positive and negative regulation of the transcription of the human protein kinase C beta gene. (1992) (24)
- Expression and localisation of apical junctional complex proteins in lens epithelial cells. (2008) (24)
- The second phase activation of protein kinase C δ at late G1 is required for DNA synthesis in serum‐induced cell cycle progression (2003) (23)
- High expression of KIBRA in low atypical protein kinase C‐expressing gastric cancer correlates with lymphatic invasion and poor prognosis (2013) (23)
- Direct evidence that the kinase activity of protein kinase C is involved in transcriptional activation through a TPA‐responsive element (1989) (23)
- Regulation of δ protein kinase C during rat ovarian differentiation (1993) (23)
- aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA-binding ability (2018) (22)
- Tumor Necrosis Factor Signaling to Stress-activated Protein Kinase ( SAPK ) / Jun (1998) (22)
- A novel member of the calcium-dependent cysteine protease family. (1990) (21)
- The interactions of androgen receptor with poly(A)-containing RNA and polyribonucleotides. (2005) (21)
- Atypical Protein Kinase C Isoform, aPKCλ, Is Essential for Maintaining Hair Follicle Stem Cell Quiescence. (2015) (21)
- Transcriptional activation of the gene for the large subunit of human m‐calpain by 12‐o‐tetradecanoyl‐phorbol‐13‐acetate (1992) (21)
- Coexpression of aPKCλ/ι and IL‐6 in prostate cancer tissue correlates with biochemical recurrence (2011) (20)
- Increased degradation of protein kinase C without diminution of mRNA level after treatment of WEHI-231 B lymphoma cells with phorbol esters. (1988) (20)
- The binding of androgen receptor to DNA and RNA. (1981) (20)
- Proliferation in the posterior region of the lens of c-maf-/- mice (2001) (20)
- Three-dimensional studies of cytoskeletal organizations in cultured thyroid cells by quick-freezing and deep-etching method. (1989) (19)
- Phosphatidic Acid‐Dependent Phosphorylation of a 29‐kDa Protein by Protein Kinase Cα in Bovine Brain Cytosol (1998) (19)
- Requirements of follicle structure for thyroid hormone synthesis; cytoskeletons and iodine metabolism in polarized monolayer cells on collagen gel and in double layered, follicle-forming cells. (1992) (19)
- Primary structures of human protein kinase C beta I and beta II differ only in their C-terminal sequences. (1987) (19)
- Involvement of protein kinase C ε in thyrotropin‐releasing hormone‐stimulated phosphorylation of the myristoylated alanine‐rich C kinase substrate in rat pituitary clonal cells (2000) (19)
- Localization and developmental expression of a novel protein kinase C delta gene. (1992) (18)
- MEK Kinase Is Involved in Tumor Necrosis Factor a-Induced NF-kB Activation and Degradation of IkB-a* (1996) (18)
- Loss of aPKCλ in Differentiated Neurons Disrupts the Polarity Complex but Does Not Induce Obvious Neuronal Loss or Disorientation in Mouse Brains (2013) (18)
- Regulation of Transformed State by Calpastatin via PKCϵ in NIH3T3 Mouse Fibroblasts (2002) (18)
- Nicotine enhances the malignant potential of human pancreatic cancer cells via activation of atypical protein kinase C. (2016) (18)
- Analysis of interferon-beta mRNA stability control after poly(I:C) stimulation using RNA metabolic labeling by ethynyluridine. (2012) (18)
- Concanavalin A-induced attachment of spermatogenic cells to Sertoli cells in vitro. (1982) (18)
- Involvement of protein kinase C in the activation of extracellular signal-regulated kinase 1/2 by UVC irradiation. (1997) (18)
- The KIBRA-aPKC connection (2012) (17)
- Involvement of PKC βII in anti‐proliferating action of a new antitumor compound gnidimacrin (2003) (17)
- A novel yeast gene coding for a putative protein kinase. (1989) (16)
- Nucleotide sequence of the 3' portion of a human gene for protein kinase CβI/βII (1987) (16)
- Differential expression of protein kinase C genes in cultured mast cells derived from normal and mast-cell-deficient mice and mast cell lines. (1994) (16)
- Tumor suppressor protein Lgl mediates G1 cell cycle arrest at high cell density by forming an Lgl-VprBP-DDB1 complex (2015) (16)
- Polarized thyroid cells in monolayers cultured on collagen gel: their cytoskeleton organization, iodine uptake, and resting membrane potentials. (1988) (16)
- Primary structure of a gamma subunit of G protein, gamma 12, and its phosphorylation by protein kinase C. (1995) (15)
- aPKCλ/ι is a beneficial prognostic marker for pancreatic neoplasms. (2013) (15)
- Protein kinase C ε phosphorylates keratin 8 at Ser8 and Ser23 in GH4C1 cells stimulated by thyrotropin‐releasing hormone (2007) (15)
- Evidence for a new, high-molecular weight isoform of protein kinase C in rat hippocampus (1993) (15)
- A metalloprotease – disintegrin , MDC 9 / meltrin-γ / ADAM 9 and PKC δ are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor (2013) (15)
- Interactions of nuclear estrogen receptor with DNA and RNA. (1983) (14)
- A novel function of the cell polarity-regulating kinase PAR-1/MARK in dendritic spines (2011) (13)
- Renal cell carcinoma- and pheochromocytoma-specific altered gene expression profiles in VHL mutant clones. (2005) (12)
- Simple Construction of Human c‐myc Gene Implicated in B‐Cell Neoplasmas and Its Relationship with Avian v‐myc and Human Lymphokines (1983) (12)
- [30] Cloning and evolution of calcium-dependent protease, cDNA cloning of a novel family of calcium-binding proteins (1987) (12)
- Developmental changes in the expression pattern of the JNK activator kinase MUK/DLK/ZPK and active JNK in the mouse cerebellum (2006) (12)
- IDENTIFICATION AND DISTRIBUTION OF mRNA FOR CALCIUM-ACTIVATED NEUTRAL PROTEASE (CANP) (1988) (11)
- Neonatal pancreatic cells redifferentiate into both neural and pancreatic lineages. (2007) (11)
- Conformation‐dependent activation of type II adenylyl cyclase by protein kinase C (1997) (11)
- Distinct types of stem cell divisions determine organ regeneration and aging in hair follicles (2021) (11)
- Regulation of Asymmetric Division by Atypical Protein Kinase C Influences Early Specification of CD8+ T Lymphocyte Fates (2016) (11)
- Colorectal laterally spreading tumors show characteristic expression of cell polarity factors, including atypical protein kinase C λ/ι, E-cadherin, β-catenin and basement membrane component (2014) (11)
- Shank2 Binds to aPKC and Controls Tight Junction Formation with Rap1 Signaling during Establishment of Epithelial Cell Polarity. (2020) (11)
- Regulation of the alternative splicing of sarcoplasmic reticulum Ca²⁺-ATPase1 (SERCA1) by phorbol 12-myristate 13-acetate (PMA) via a PKC pathway. (2012) (11)
- The PAR3-aPKC-PAR6 Complex (2015) (11)
- A Ca(2+)-independent protein kinase C, nPKC eta: its structure, distribution and possible function. (1992) (10)
- A new protein kinase C, nPKC eta', and nPKC theta are expressed in human platelets: involvement of nPKC eta' and nPKC theta in signal transduction stimulated by PAF. (1993) (10)
- Aberrant Expression of the Cell Polarity Regulator aPKC&lgr;/&igr; is Associated With Disease Progression in Cervical Intraepithelial Neoplasia (CIN): A Possible Marker for Predicting CIN Prognosis (2016) (10)
- Symmetrically dividing cell specific division axes alteration observed in proteasome depleted C. elegans embryo (2008) (9)
- Mammalian Lectin as Transforming Growth Factor (1993) (9)
- Primary structure and evolution of calcium-activated neutral protease (CANP) (1987) (9)
- A protein kinase C isozyme, nPKC epsilon, is involved in the activation of NF-kappa B by 12-O-tetradecanoylphorbol-13-acetate (TPA) in rat 3Y1 fibroblasts. (1995) (9)
- Aberrant activation of atypical protein kinase C in carbon tetrachloride-induced oxidative stress provokes a disturbance of cell polarity and sealing of bile canalicular lumen. (2015) (9)
- Structure and properties of a ubiquitously expressed protein kinase C, nPKC delta. (1991) (8)
- A yeast gene coding for a putative protein kinase homologous to cdc25 suppressing protein kinase (1987) (8)
- The interaction of Kinesin-1 with its adaptor protein JIP1 can be regulated via proteins binding to the JIP1-PTB domain (2013) (8)
- Imaging and Antitumoral Effect of a Cyclo-oxygenase 2-specific Replicative Adenovirus for Small Metastatic Gastric Cancer Lesions. (2015) (8)
- Atypical protein kinase C isoforms differentially regulate directional keratinocyte migration during wound healing. (2019) (7)
- Structure and function of the small (30K) subunit of calcium-activated neutral protease (CANP). (1986) (7)
- Nucleotide sequence of chick 14K beta-galactoside-binding lectin mRNA. (1986) (7)
- Expression in lung tumors and genetic mapping of the novel murine protein kinase Cη (1994) (7)
- Aberrant Nuclear Localization of aPKCλ/ι is Associated With Poorer Prognosis in Uterine Cervical Cancer (2019) (7)
- Dominant negative effect of the truncated p110 subunit of phosphatidylinositol‐3 kinase (1996) (7)
- Atypical Protein Kinase C λ/ι Expression Is Associated with Malignancy of Oral Squamous Cell Carcinoma (2018) (6)
- Regulation of transformed state by calpastatin via PKCepsilon in NIH3T3 mouse fibroblasts. (2002) (6)
- Studies on the physicochemical structure and stability of an active fragment (T2A) of colicin E3. (1980) (6)
- High PKCλ expression is required for ALDH1-positive cancer stem cell function and indicates a poor clinical outcome in late-stage breast cancer patients (2020) (6)
- sPAR-3, a splicing variant of PAR-3, shows cellular localization and an expression pattern different from that of PAR-3 during enterocyte polarization. (2005) (6)
- Recurrence of 49-base decamers, nonomers, and octamers within mouse C mu gene of Ig heavy chain and its primordial building block. (1983) (6)
- Cell type-specific expression of the genes for the protein kinase C family: down regulation of mRNAs for PKC alpha and nPKC epsilon upon in vitro differentiation of a mouse neuroblastoma cell line neuro 2a. (1989) (6)
- [mRNA surveillance]. (2002) (5)
- Differential effects of overexpression of PKC alpha and PKC delta/epsilon on cellular E2F activity in late G1 phase. (1996) (5)
- Atypical protein kinase C k binds and regulates p70 S6 kinase (1998) (5)
- Conditionally replicative adenoviral vectors for imaging the effect of chemotherapy on pancreatic cancer cells (2013) (5)
- Nucleotide sequence of the 3' portion of a human gene for protein kinase C beta I/beta II. (1987) (5)
- Possible role of Ca2(+)-independent protein kinase C isozyme, nPKC epsilon, in thyrotropin-releasing hormone-stimulated signal transduction: differential down-regulation of nPKC epsilon in GH4C1 cells. (1990) (5)
- Extrinsic Wnt signalling controls the polarity component aPKC (2007) (5)
- Structure and Expression of a Cloned cDNA for Mouse Interferon-@ * (2001) (5)
- Glyoxalase 1 and protein kinase Cλ as potential therapeutic targets for late-stage breast cancer (2021) (5)
- Primary Structure of a (cid:103) Subunit of G Protein, (cid:103) 12 , and Its Phosphorylation by Protein Kinase C* (1995) (5)
- Learning-Induced Suboptimal Compensation for PKC&igr;/&lgr; Function in Mutant Mice (2017) (4)
- Activated Atypical Protein Kinase C (2001) (4)
- The Asymmetric Cell Division Regulators Par3, Scribble and Pins/Gpsm2 Are Not Essential for Erythroid Development or Enucleation (2017) (4)
- EXPRESSION OF THE CLONED GENES FOR HUMAN INTERFERON β 1 IN E. COLI AND IN CULTURED MOUSE CELLS (1982) (4)
- Molecular cloning and expression of human leukotriene A4 hydrolase cDNA. (1989) (3)
- Role of SMG-1-mediated Phosphorylation of Upf1 in NMD (2013) (3)
- Phosphatidylinositol 3-kinase is involved in TRE-dependent gene expression in response to arginine vasopressin. (1995) (3)
- Deletion Mutant of Protein Kinase Cpll Inhibits Insulin-Stimulated 2- Deoxyglucose Uptake in L6 Rat Skeletal Muscle Cells (1996) (3)
- Concentration-dependent phorbol stimulation of PKCα localization at the nucleus or subplasmalemma in A7r5 cells (2001) (3)
- Phosphorylation and dephosphorylation of Ser852 and Ser889 control the clustering, localization and function of PAR3 (2020) (3)
- Adriamycin resistance in MCF-7 cells expressing P-glycoprotein following transfection with protein kinase C alpha (1990) (3)
- Analysis of nonsense-mediated mRNA decay by monitoring mRNA half-lives in mammalian cells. (2010) (2)
- Phosphorylation and dephosphorylation of Ser852 and Ser889 control clustering, localization, and function of PAR3. (2020) (1)
- - PKC: Protein kinase C (vertebrates) (Ca2+-and phospholipid-dependent PK) (1995) (1)
- [Regulation of epithelial cell polarity mediated by aPKC-PAR complex]. (2006) (1)
- The interaction of Kinesin-1 with its adaptor protein JIP1 can be regulated via proteins binding to the JIP1-PTB domain (2013) (1)
- Regulation of Plasma Low Density Lipoprotein Levels Biopharmacological Regulation of Protein Phosphorylation Calcium-Activated Neutral Protease Microbial Iron Transport Pharmacokinetic Drug Interactions (1988) (1)
- PKC gamma gene expression is delayed in postnatal central nervous system of mi/mi mice. (1993) (1)
- Phosphorylation and dephosphorylation of Ser852 and Ser889 control clustering, localization, and function of PAR-3 (2020) (1)
- KIBRA‐aPKC Connection: High expression of KIBRA in High Invasion and Poor Prognosis. Overexpression of the aPKC‐binding region of KIBRA affects tight junction formation in epithelial cells. (2013) (1)
- INTERCELLULAR ADHESION OF MALE GERM CELLS AND SERTOLI CELLS INDUCED BY CONCANAVALIN A (1982) (1)
- PKCγ gene expression is delayed in postnatal central nervous system ofmi/mi mice (2008) (1)
- The -q Isoform of Protein Kinase C Is Localized on Rough Endoplasmic Reticulum (1)
- Founding Editor Editor-in-chief Regional Editors Editorial Board Springer International Contents Abe, Sa: Meiosis of Primary Spermatocytes and Early Sper- Miogenesis in the Resultant Spermatids in Newt, Cynops Pyrrhogaster in Vitro 65 Heterogeneity of Inter- Mediate Filament Expression in Vascular S (0)
- Predominant expression of nPKCη, a newly isolated Ca2+-independent protein kinase C in mouse skin (1991) (0)
- The role of SMG-1, a member of the PIKK [phosphoinositide 3-kinase related kinases] family, in mRNA surveillance; Molecular mechanism and therapeutic implications (2005) (0)
- Cell Polarity and Apical Junctional Complex Regulated by aPKC During Lens Formation (2006) (0)
- ASIP/PAR3 is located at the slit diaphragm in podocyte (2002) (0)
- The translational read-through reporter system for analysis of molecular mechanism (2016) (0)
- INTERCELLULAR ADHESION OF SERTOLI CELLS AND GERM CELLS INDUCED BY CONCANAVALIN A (1981) (0)
- [Studies on the molecular multiplicity, structure, and function of the protein kinase C family]. (1989) (0)
- [Structure and function of protein kinase C]. (1990) (0)
- Supplement II: Abstracts of the international symposium on Skin Carcinogenesis in man and in experimental models. Heidelberg, 29–31 October 1991 (pp S61–S88) (1991) (0)
- ABSTRACTS | Hair, Cutaneous Homeostasis and Stem Cell Functions (2010) (0)
- Table of Contents (1996) (0)
- [Identification and functional analysis of novel proteins deduced from the cDNA sequences: protein kinase C related proteins]. (1990) (0)
- ALTERATIONS IN THE EXPRESSION OF THE PROTEIN-KINASE-C ISOTYPES IN HUMAN CELL-LINES AND TISSUE BIOPSIES (1994) (0)
- A Cat-Independent Protein Kinase nPKC v : Its Structure , Distribution Possible Function (2006) (0)
- Protein-dna antigens in balb/c mice. Abstr. (1972) (0)
- Ionization yield produced in gases by heavy ions. Classical mechanical understanding of radiation action on matter, 2 (1974) (0)
- [Calcium-activated neutral protease and its endogenous inhibitor: structure and function]. (1988) (0)
- A cell polarity protein, aPKCλ, is essential for maintaining hair follicle stem cell quiescence and hair follicle regeneration (2016) (0)
- A New MemberoftheProtein Kinase C Family, nPKCO, Predominantly Expressed inSkeletal Muscle (1992) (0)
- PERIPHERAL T-CELL TOLERANCE BY ADMINISTRATION OF SUPERANTIGEN INTO ANTERIOR CHAMBER (1994) (0)
- Figure 3, [Hypothetical model showing the roles...]. (2013) (0)
- 663 Differential roles of atypical protein kinase C isoforms in wound healing (2017) (0)
- [An aspect of the research on protein kinase C]. (1996) (0)
- Cloning of leukotriene A4 hydrolase cDNA. (1990) (0)
- [Regulation of cell polarity in establishment of epithelium]. (2006) (0)
- [Intracellular signaling system as a network of signaling circuits]. (1994) (0)
- Abstract 1519: In laterally spreading type tumors (LSTs) of the colon or the rectum, expression of the atypical protein kinase C lambda/iota is correlated to expression of beta-catenin and Type IV collagen (2011) (0)
- Proteine de liaison smg-1 et methode de criblage de substance regulant son activite (2003) (0)
- Post-transactional gene expression regulation via PI3 kinase related protein kinase SMG1 (2016) (0)
- Protein Kinase Cr 31 and Protein Kinase C 2 Activate p 57 Mitogen-activated Protein Kinase and Block Differentiation in Colon Carcinoma Cells (2005) (0)
- aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA-binding ability (2018) (0)
- - Ykr2: Ykr2 PK (S. cerevisiae) (1995) (0)
- Conditional Depletion of aPKC in Eye Lens Causes Microphthalmia and Cataract (2008) (0)
- Immunohistochemical study of phosphorylated Tau Protein in Oxidized Diacylglycerol-treated Cultured Neurons Overexpressing PKCα and δ isoforms. : (1999) (0)
- Primary structure and function of calcium activated neutralprotease (1986) (0)
- large-scale conformational changes controlled by SMG-8 The nonsense-mediated mRNA decay SMG-1 kinase is regulated by Material Supplemental (2011) (0)
- P2-14 Involvement of mammalian PAR-6 in the establishment of epithelial junctional structures (2002) (0)
- aPKC contributes to Planar Cell Polarity regulation (2016) (0)
- Induction of MST/MLK2 mRNA by heat shock (1998) (0)
- Protein Kinase C ζ Kinase C T Lymphocyte Fate Specification by Protein + Regulation of Asymmetric Division and CD 8 (2015) (0)
- Title Translation-dependent unwinding of stem ‒ loops by UPF 1 licenses Regnase-1 to degrade inflammatory mRNAs (2019) (0)
- aPKC interacts with p200 to control epithelial cell polarity (2017) (0)
- Structure and Activity-Regulation of Chimeric Proteins a Case Study of Calcium-Activated Neutral Protease (1987) (0)
- The phosphorylation of HIV-1 Gag by atypical protein kinase C facilitates viral infectivity by promoting Vpr incorporation into virions (2014) (0)
- The sequence of human interferon-3,1 gene is responsible for viral induction of transription (2003) (0)
- Development of the efficient monitoring system of the post-transcriptional gene expression regulation (2015) (0)
- [Structural biology of protein kinase C]. (1999) (0)
- EXPRESSION OF THE HUMAN INTERFERON-β1 GENE IN HETEROLOGOUS HOST CELLS (1983) (0)
- PAR3 restricts the expansion of neural precursor cells by regulating hedgehog signaling. (2022) (0)
- The function of PAR3 in the regulation of hedgehog signaling in primary cilia in neuroepithelial cells (2017) (0)
- Abstract 5176: Expression of the atypical protein kinase C combined with expression of other factors is important for determination of structures in lateral spreading type tumors of the colon or the rectum (2010) (0)
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