Shigeo Ohta

Q: What Schools Are Affiliated With Shigeo Ohta

Shigeo Ohta is affiliated with the following schools: University of Oxford, University of Tokyo, Nagasaki University, Nippon Medical School, Keio University, Jichi Medical University, Juntendo University, Kyoto University

Shigeo Ohta's AcademicInfluence.com Rankings

Shigeo Ohta

Biology

#12299

World Rank

#15766

Historical Rank

Genetics

#1352

World Rank

#1454

Historical Rank

biology Degrees

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Biology

Shigeo Ohta's Degrees

PhD Biology Kyoto University

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Shigeo Ohta's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals (2007) (1715)
Deficiencies in complex I subunits of the respiratory chain in Parkinson's disease. (1989) (749)
Mitochondrial genome variation in eastern Asia and the peopling of Japan. (2004) (525)
Introduction of disease-related mitochondrial DNA deletions into HeLa cells lacking mitochondrial DNA results in mitochondrial dysfunction. (1991) (517)
Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury. (2008) (411)
FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets. (2008) (374)
A point mutation in the mitochondrial tRNA(Leu)(UUR) gene in MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes). (1990) (341)
Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress. (2007) (319)
Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine. (2014) (298)
Positive contribution of pathogenic mutations in the mitochondrial genome to the promotion of cancer by prevention from apoptosis. (2005) (277)
Codon-specific translational defect caused by a wobble modification deficiency in mutant tRNA from a human mitochondrial disease. (2004) (263)
Modification Defect at Anticodon Wobble Nucleotide of Mitochondrial tRNAsLeu(UUR) with Pathogenic Mutations of Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like Episodes* (2000) (241)
Consumption of Molecular Hydrogen Prevents the Stress-Induced Impairments in Hippocampus-Dependent Learning Tasks during Chronic Physical Restraint in Mice (2009) (237)
Wobble modification defect in tRNA disturbs codon–anticodon interaction in a mitochondrial disease (2001) (223)
Hydrogen therapy reduces apoptosis in neonatal hypoxia–ischemia rat model (2008) (220)
Recent Progress Toward Hydrogen Medicine: Potential of Molecular Hydrogen for Preventive and Therapeutic Applications (2011) (216)
Protection against ischemic brain injury by protein therapeutics (2002) (191)
Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease (2009) (187)
Structure-antibacterial activity relationships of anacardic acids (1993) (180)
Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice. (2008) (167)
Deficiency in mitochondrial aldehyde dehydrogenase increases the risk for late-onset Alzheimer's disease in the Japanese population. (2000) (165)
Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice (2009) (161)
Astaxanthin protects mitochondrial redox state and functional integrity against oxidative stress. (2010) (159)
Mutations in the TIGR gene in familial primary open-angle glaucoma in Japan. (1997) (158)
Molecular Hydrogen Improves Obesity and Diabetes by Inducing Hepatic FGF21 and Stimulating Energy Metabolism in db/db Mice (2011) (157)
Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases. (2012) (147)
Association of polymorphisms in the estrogen receptor α gene with body fat distribution (2003) (139)
Protection of the retina by rapid diffusion of hydrogen: administration of hydrogen-loaded eye drops in retinal ischemia-reperfusion injury. (2010) (138)
Postmortem changes in mitochondrial respiratory enzymes in brain and a preliminary observation in Parkinson's disease (1990) (133)
Defect in modification at the anticodon wobble nucleotide of mitochondrial tRNALys with the MERRF encephalomyopathy pathogenic mutation (2000) (124)
Sequence and over-expression of subunits of adenosine triphosphate synthase in thermophilic bacterium PS3. (1988) (124)
Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress. (2011) (124)
Molecular hydrogen as a novel antioxidant: overview of the advantages of hydrogen for medical applications. (2015) (123)
Deficiency in a mitochondrial aldehyde dehydrogenase increases vulnerability to oxidative stress in PC12 cells (2003) (122)
Nuclear but not mitochondrial genome involvement in human age-related mitochondrial dysfunction. Functional integrity of mitochondrial DNA from aged subjects. (1994) (120)
Pilot study of H2 therapy in Parkinson's disease: A randomized double‐blind placebo‐controlled trial (2013) (118)
Blue light‐induced oxidative stress in live skin (2017) (117)
Metabolic Remodeling Induced by Mitochondrial Aldehyde Stress Stimulates Tolerance to Oxidative Stress in the Heart (2009) (114)
Association of transferrin C2 allele with late-onset Alzheimer’s disease (1997) (110)
Mitochondrial ALDH2 Deficiency as an Oxidative Stress (2004) (107)
Age-Dependent Neurodegeneration Accompanying Memory Loss in Transgenic Mice Defective in Mitochondrial Aldehyde Dehydrogenase 2 Activity (2008) (107)
Dysfunction of mitochondria and oxidative stress in the pathogenesis of Alzheimer's disease: on defects in the cytochrome c oxidase complex and aldehyde detoxification. (2006) (100)
Respiration-deficient cells are caused by a single point mutation in the mitochondrial tRNA-Leu (UUR) gene in mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes (MELAS). (1991) (100)
Crystal Structure of Rat Bcl-xL (1997) (97)
Molecular hydrogen regulates gene expression by modifying the free radical chain reaction-dependent generation of oxidized phospholipid mediators (2016) (94)
Inhibition of endothelial p53 improves metabolic abnormalities related to dietary obesity. (2013) (94)
Hydrogen Gas Inhalation Treatment in Acute Cerebral Infarction: A Randomized Controlled Clinical Study on Safety and Neuroprotection. (2017) (92)
Association of polymorphisms in the estrogen receptor alpha gene with body fat distribution. (2003) (92)
Are the effects of α‐glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract? (2009) (90)
A purified precursor polypeptide requires a cytosolic protein fraction for import into mitochondria. (1984) (89)
Caloric Restriction Primes Mitochondria for Ischemic Stress by Deacetylating Specific Mitochondrial Proteins of the Electron Transport Chain (2011) (88)
Functional integrity of mitochondrial genomes in human platelets and autopsied brain tissues from elderly patients with Alzheimer's disease. (1999) (83)
An Additional Form of Rat Bcl-x, Bcl-xβ, Generated by an Unspliced RNA, Promotes Apoptosis in Promyeloid Cells* (1996) (82)
A yeast mutant temperature‐sensitive for mitochondrial assembly is deficient in a mitochondrial protease activity that cleaves imported precursor polypeptides. (1985) (81)
Functional and morphological abnormalities of mitochondria in human cells containing mitochondrial DNA with pathogenic point mutations in tRNA genes. (1994) (80)
H2 Gas Improves Functional Outcome After Cardiac Arrest to an Extent Comparable to Therapeutic Hypothermia in a Rat Model (2012) (78)
Multiple deletions in mitochondrial DNA at direct repeats of non-D-loop regions in cases of familial mitochondrial myopathy. (1989) (77)
Association of polymorphisms of the estrogen receptor α gene with bone mineral density of the femoral neck in elderly Japanese women (2002) (75)
Accumulation of mtDNA with a mutation at position 3271 in tRNA(Leu)(UUR) gene introduced from a MELAS patient to HeLa cells lacking mtDNA results in progressive inhibition of mitochondrial respiratory function. (1993) (75)
Regular voluntary exercise cures stress-induced impairment of cognitive function and cell proliferation accompanied by increases in cerebral IGF-1 and GST activity in mice (2010) (74)
Cloning and sequencing of cDNAs encoding alpha and beta subunits of human pyruvate dehydrogenase. (1988) (74)
Wobble modification deficiency in mutant tRNAs in patients with mitochondrial diseases (2005) (69)
Phosphorylation of Nephrin Triggers Ca2+ Signaling by Recruitment and Activation of Phospholipase C-γ1* (2009) (68)
Mitochondrial membrane potential decrease caused by loss of PINK1 is not due to proton leak, but to respiratory chain defects (2011) (66)
Gene structure of the human mitochondrial adenosine triphosphate synthase beta subunit. (1988) (65)
Prognostic significance of the immunohistochemical index of survivin in glioma: a comparative study with the MIB-1 index (2005) (64)
Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment (2018) (63)
α3β3 complex of thermophilic ATP synthase Catalysis without the γ‐subunit (1989) (62)
Hydrogen Inhalation During Normoxic Resuscitation Improves Neurological Outcome in a Rat Model of Cardiac Arrest Independently of Targeted Temperature Management (2014) (62)
Haploinsufficiency of Akt1 Prolongs the Lifespan of Mice (2013) (61)
Preventive effects of Chlorella on cognitive decline in age-dependent dementia model mice (2009) (61)
Aldehyde‐stress resulting from Aldh2 mutation promotes osteoporosis due to impaired osteoblastogenesis (2012) (59)
Taurine supplementation for prevention of stroke-like episodes in MELAS: a multicentre, open-label, 52-week phase III trial (2018) (59)
MIDAS/GPP34, a nuclear gene product, regulates total mitochondrial mass in response to mitochondrial dysfunction (2005) (59)
Mutations in the mitochondrial genome confer resistance of cancer cells to anticancer drugs (2009) (58)
Nucleotide binding to isolated alpha and beta subunits of proton translocating adenosine triphosphatase studied with circular dichroism. (1980) (58)
Defective gene in lactic acidosis: abnormal pyruvate dehydrogenase E1 alpha-subunit caused by a frame shift. (1989) (55)
Studies on polypeptide-chain-elongation factors from an extreme thermophile, Thermus thermophilus HB8. 3. Molecular properties. (1978) (54)
Site-directed mutagenesis of stable adenosine triphosphate synthase. (1988) (53)
A pathogenic point mutation reduces stability of mitochondrial mutant tRNA(Ile). (2000) (52)
Complete cDNA encoding a putative phospholipase C from transformed human lymphocytes (1988) (52)
Suppression of endoplasmic reticulum stress-induced caspase activation and cell death by the overexpression of Bcl-xL or Bcl-2. (2006) (51)
Human F1-ATPase: molecular cloning of cDNA for the beta subunit. (1986) (50)
Novel regulatory enhancer in the nuclear gene of the human mitochondrial ATP synthase beta-subunit. (1990) (49)
Accumulation of somatic mutation in mitochondrial DNA extracted from peripheral blood cells in diabetic patients (2002) (49)
Feasibility and Safety of Hydrogen Gas Inhalation for Post-Cardiac Arrest Syndrome　- First-in-Human Pilot Study. (2016) (48)
Oxidative stress accelerates amyloid deposition and memory impairment in a double-transgenic mouse model of Alzheimer's disease (2015) (48)
Genetic deficiency of a mitochondrial aldehyde dehydrogenase increases serum lipid peroxides in community-dwelling females (2003) (47)
Molecular hydrogen stimulates the gene expression of transcriptional coactivator PGC-1α to enhance fatty acid metabolism (2016) (44)
Effects of ethidium bromide treatment of mouse cells on expression and assembly of nuclear-coded subunits of complexes involved in the oxidative phosphorylation. (1990) (44)
A multi-functional organelle mitochondrion is involved in cell death, proliferation and disease. (2003) (44)
Molecular hydrogen protects chondrocytes from oxidative stress and indirectly alters gene expressions through reducing peroxynitrite derived from nitric oxide (2011) (44)
Clinical Effects of Hydrogen Administration: From Animal and Human Diseases to Exercise Medicine (2016) (43)
The Super Anti-apoptotic Factor Bcl-xFNK Constructed by Disturbing Intramolecular Polar Interactions in Rat Bcl-xL * (2000) (43)
A Trace Amount of the Human Pro-apoptotic Factor Bax Induces Bacterial Death Accompanied by Damage of DNA* (1998) (43)
Real-time monitoring of oxidative stress in live mouse skin. (2014) (42)
Invitro mutated β subunits from the F1-ATPase of the thermophilic bacterium, PS3, containing glutamine in place of glutamic acid in positions 190 or 201 assembles with the α and γ subunits to produce inactive complexes (1987) (41)
Gene structure of human mitochondrial ATP synthase gamma-subunit. Tissue specificity produced by alternative RNA splicing. (1993) (39)
Immunochemical and immunohistochemical localization of Bcl-x protein in the rat central nervous system (1996) (38)
Content of mutant mitochondrial DNA and organ dysfunction in a patient with a MELAS subgroup of mitochondrial encephalomyopathies (1993) (38)
Taurine ameliorates impaired the mitochondrial function and prevents stroke-like episodes in patients with MELAS. (2012) (38)
Involvement of mitoKATP channel in protective mechanisms of cerebral ischemic tolerance (2008) (38)
Intersubunit interactions in proton-translocating adenosine triphosphatase as revealed by hydrogen-exchange kinetics. (1980) (37)
Endurance exercise training inhibits activity of plasma GOT and liver caspase-3 of rats exposed to stress by induction of heat shock protein 70 (2004) (36)
Isolation, characterization and structural organization of the gene and pseudogene for the dihydrolipoamide succinyltransferase component of the human 2-oxoglutarate dehydrogenase complex. (1994) (35)
Nucleotide sequence of the gene coding for cytochrome oxidase subunit I from the thermophilic bacterium PS3. (1988) (35)
Therapeutic benefits of intrathecal protein therapy in a mouse model of amyotrophic lateral sclerosis (2008) (35)
Low density lipoprotein receptor‐related protein gene polymorphisms and risk for late‐onset Alzheimer's disease in a Japanese population (2000) (34)
An extremely acidic amino‐terminal presequence of the precursor for the human mitochondrial hinge protein (1987) (33)
Marked decrease of mitochondrial DNA with multiple deletions in a patient with familial mitochondrial myopathy. (1990) (33)
Alzheimer's disease and DLST genotype (1997) (33)
Upstream region of a genomic gene for human mitochondrial transcription factor 1. (1992) (32)
Nucleotide sequence of cDNA encoding human cytochrome c oxidase subunit VIc. (1988) (32)
Purification and molecular cloning of succinyltransferase of the rat alpha-ketoglutarate dehydrogenase complex. Absence of a sequence motif of the putative E3 and/or E1 binding site. (1991) (31)
Distribution of geriatric disease-related genotypes in the National Institute for Longevity Sciences, Longitudinal Study of Aging (NILS-LSA). (2000) (31)
Overexpression of KLF15 Transcription Factor in Adipocytes of Mice Results in Down-regulation of SCD1 Protein Expression in Adipocytes and Consequent Enhancement of Glucose-induced Insulin Secretion* (2011) (31)
Expression of the apoptosis-mediator Fas is enhanced by dysfunctional mitochondria. (1996) (31)
Accumulation of Somatic Mutation in Mitochondrial DNA and Atherosclerosis in Diabetic Patients (2004) (30)
Oral supplementation with melon superoxide dismutase extract promotes antioxidant defences in the brain and prevents stress-induced impairment of spatial memory (2009) (30)
ALDH2/ADH2 polymorphism associated with vasculopathy and neuropathy in type 2 diabetes. (2004) (29)
PTD-mediated delivery of anti-cell death proteins/peptides and therapeutic enzymes. (2008) (29)
Prognosis of glioma patients by combined immunostaining for survivin, Ki-67 and epidermal growth factor receptor (2008) (29)
The α-ketoacid dehydrogenase complexes. Sequence similarity of rat pyruvate dehydrogenase with Escherichia coli and Azotobacter vinelandii α-ketoglutarate dehydrogenase (1991) (28)
Regular Moderate or Intense Exercise Prevents Depression-Like Behavior without Change of Hippocampal Tryptophan Content in Chronically Tryptophan-Deficient and Stressed Mice (2013) (28)
Overexpressed mitochondrial hinge protein, a cytochrome c-binding protein, accelerates apoptosis by enhancing the release of cytochrome c from mitochondria. (1998) (28)
Transduction of anti-apoptotic proteins into chondrocytes in cartilage slice culture. (2004) (28)
Molecular cloning of dihydrolipoamide acetyltransferase of the rat pyruvate dehydrogenase complex: sequence comparison and evolutionary relationship to other dihydrolipoamide acyltransferases. (1992) (27)
Prevention of chemotherapy-induced alopecia by the anti-death FNK protein. (2008) (26)
Drinking Hydrogen Water Enhances Endurance and Relieves Psychometric Fatigue: Randomized, Double-blind, Placebo-controlled Study. (2019) (26)
Protective effect of molecular hydrogen against oxidative stress caused by peroxynitrite derived from nitric oxide in rat retina (2015) (26)
Pore formation domain of human pro-apoptotic Bax induces mammalian apoptosis as well as bacterial death without antagonizing anti-apoptotic factors. (1998) (26)
Increased expression of carnitine palmitoyltransferase I gene is repressed by administering L-carnitine in the hearts of carnitine-deficient juvenile visceral steatosis mice. (1996) (26)
Protection of hepatic cells from apoptosis induced by ischemia/reperfusion injury by protein therapeutics (2007) (25)
Human dihydrolipoamide succinyltransferase: cDNA cloning and localization on chromosome 14q24.2-q24.3. (1993) (25)
Combination therapy with transductive anti-death FNK protein and FK506 ameliorates brain damage with focal transient ischemia in rat. (2008) (25)
ΔFosB, but not FosB, induces delayed apoptosis independent of cell proliferation in the Rat1a embryo cell line (2003) (25)
Alcohol dehydrogenase 2 variant is associated with cerebral infarction and lacunae (2004) (25)
Cytoprotective role of mitochondrial amyloid β peptide-binding alcohol dehydrogenase against a cytotoxic aldehyde (2009) (24)
A protein derived from the fusion of TAT peptide and FNK, a Bcl‐xL derivative, prevents cochlear hair cell death from aminoglycoside ototoxicity in vivo (2007) (24)
Transduction of anti-cell death protein FNK protects isolated rat hearts from myocardial infarction induced by ischemia/reperfusion. (2007) (24)
Clinical phenotype of a Japanese family with primary open angle glaucoma caused by a Pro370Leu mutation in the MYOC/TIGR gene. (1999) (24)
Truncated product of the bifunctional DLST gene involved in biogenesis of the respiratory chain (2003) (23)
Regulation of mitochondrial ATP synthesis in mammalian cells by transcriptional control. (1990) (23)
Structural fluctuation of the polypeptide-chain elongation factor Tu. A comparison of factors from Escherichia coli and Thermus thermophilus HB8. (1977) (22)
Zonal necrosis prevented by transduction of the artificial anti-death FNK protein (2005) (22)
Acute Supplementation with Molecular Hydrogen Benefits Submaximal Exercise Indices. Randomized, Double-Blinded, Placebo-Controlled Crossover Pilot Study (2019) (22)
The α1β1 heterodimer, the unit of ATP synthase (1991) (22)
Smaller isoform of human mitochondrial transcription factor 1: its wide distribution and production by alternative splicing. (1993) (22)
Detection of urine survivin in 40 patients with bladder cancer. (2004) (22)
Acute immobilization stress following contextual fear conditioning reduces fear memory: timing is essential (2016) (21)
[Initiation, development and potential of hydrogen medicine: Toward therapeutic and preventive applications of molecular hydrogen against a variety of diseases]. (2015) (21)
Inactive Aldehyde Dehydrogenase-2 Increased the Risk of Pancreatic Cancer Among Smokers in a Japanese Male Population (2005) (21)
The 2011 Medical Molecular Hydrogen Symposium: An inaugural symposium of the journal Medical Gas Research (2011) (20)
Lipoma and opthalmoplegia in mitochondrial diabetes associated with small heteroplasmy level of 3243 tRNA(Leu(UUR)) mutation. (2004) (20)
High expression of Bcl‐x protein in the developing human cerebellar cortex (1996) (19)
Nucleotide sequence of a cDNA encoding the precursor to human cytochrome c1. (1988) (19)
Endurance exercise training inhibits activity of plasma GOT and liver caspase-3 of mice [correction of rats] exposed to stress by induction of heat shock protein 70. (2004) (19)
Intravenous transplantation of bone marrow-derived mononuclear cells prevents memory impairment in transgenic mouse models of Alzheimer’s disease (2015) (19)
Widespread tissue distribution of multiple mitochondrial DNA deletions in familial mitochondrial myopathy (1994) (19)
Gene structure and cell type-specific expression of the human ATP synthase α subunit (1994) (19)
The histone 3 lysine 9 methyltransferase inhibitor chaetocin improves prognosis in a rat model of high salt diet-induced heart failure (2017) (19)
Kinetics of hydrogen-deuterium exchange in ATPase from a thermophilic bacterium PS3. (1978) (18)
Anti-apoptotic PTD-FNK protein suppresses lipopolysaccharide-induced acute lung injury in rats. (2007) (18)
Preventive effects of Chlorella on skeletal muscle atrophy in muscle-specific mitochondrial aldehyde dehydrogenase 2 activity-deficient mice (2014) (18)
[Wobble modification defect suppresses translational activity of tRNAs with MERRF and MELAS mutations]. (2002) (17)
Association of cholecystokinin-A receptor gene polymorphism with alcohol dependence in a Japanese population. (2004) (17)
Association of alcohol dehydrogenase 2*1 allele with liver damage and insulin concentration in the Japanese (2006) (17)
[Hydrogen gas and hydrogen water act as a therapeutic and preventive antioxidant with a novel concept]. (2008) (17)
Review and prospect of the biomedical effects of hydrogen (2014) (16)
Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury (2008) (16)
Cytochrome C Oxidase—deficient myogenic cell lines in mitochondrial myopathy (1989) (16)
FUNCTIONS OF SUBUNITS OF H+‐ATPASE (1980) (15)
N-terminal deletion augments the cell-death-inducing activity of BAX in adenoviral gene delivery to nonsmall cell lung cancers (2003) (15)
Bacterial cell death induced by human pro‐apoptotic Bax is blocked by an RNase E mutant that functions in an anti‐oxidant pathway (2000) (14)
Hydrogen Molecular Biology and Medicine (2015) (14)
Molecular hydrogen suppresses free radical-induced cell death by mitigating fatty acid peroxidation and mitochondrial dysfunction. (2019) (14)
The anti-cell death FNK protein protects cells from death induced by freezing and thawing. (2005) (13)
The mutant mitochondrial genes in mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) were selectively amplified through generations (1992) (12)
Feasibility and Safety of Hydrogen Gas Inhalation for Post-Cardiac Arrest Syndrome – First-inHuman Pilot Study – (2016) (12)
The α1β1 heterodimer of ATP synthase (1990) (11)
Hepatic failure and enhanced oxidative stress in mitochondrial diabetes. (2008) (11)
Mild hypothermia enhanced the protective effect of protein therapy with transductive anti-death FNK protein using a rat focal transient cerebral ischemia model (2012) (11)
Acute metabolic cataract as a first manifestation of diabetes mellitus in a 12-year-old girl (2004) (11)
Intermittent intense exercise protects against cognitive decline in a similar manner to moderate exercise in chronically stressed mice (2018) (10)
Thermotropic transition in the states of proteins in sarcoplasmic reticulum vesicles. (1977) (10)
Astaxanthin improves osteopenia caused by aldehyde-stress resulting from Aldh2 mutation due to impaired osteoblastogenesis. (2020) (9)
A polypeptide derived from mitochondrial dihydrolipoamide succinyltransferase is located on the plasma membrane in skeletal muscle. (1997) (9)
Gene Structure of the Promoter Region for the Human Pyruvate Dehydrogenase E1α Subunit and Regulation of Its Gene Expression (1989) (8)
Direct targets and subsequent pathways for molecular hydrogen to exert multiple functions: Focusing on interventions in radical reactions. (2020) (8)
Mitochondrial DNA alterations in colorectal cancer cell lines. (2011) (8)
Protective Effect of Hydrogen Gas Inhalation on Muscular Damage Using a Mouse Hindlimb Ischemia-Reperfusion Injury Model (2017) (8)
Isolation of a cDNA clone for human cytochrome c1 from a γgt11 expression library (1987) (8)
Bcl-2 completely blocks Fas-mediated apoptosis in mtDNA-depleted HeLa cells. (1997) (8)
Topical application of the antiapoptotic TAT-FNK protein prevents aminoglycoside-induced ototoxicity (2011) (8)
The α3β3 and α1β1 Complexes of ATP Synthase (1992) (8)
[Molecular mechanism of apoptosis]. (1999) (8)
Increased mitochondrial functions in human glioblastoma cells persistently infected with measles virus. (2013) (7)
Transduction of the anti-apoptotic PTD-FNK protein improves the efficiency of transplantation of bone marrow mononuclear cells. (2007) (7)
Imaging mitochondrial redox environment and oxidative stress using a redox-sensitive fluorescent protein. (2008) (7)
The αβ complexes of ATP synthase: the α3β3 oligomer and α1β1 protomer (1992) (7)
Mitochondrial tRNALeu(UUR) Mutation at Position 3243 and Symptomatic Polyneuropathy in Type 2 Diabetes (2003) (7)
[Senile dementia of Alzheimer type]. (1999) (7)
Transduction of Anti-Cell Death Protein FNK Suppresses Graft Degeneration After Autologous Cylindrical Osteochondral Transplantation (2009) (6)
Genetic analysis and clinical application in polygenic diseases. Senile dementia of Alzheimer type. (1999) (6)
The alpha-ketoacid dehydrogenase complexes. Sequence similarity of rat pyruvate dehydrogenase with Escherichia coli and Azotobacter vinelandii alpha-ketoglutarate dehydrogenase. (1991) (6)
Improvement of the post-thaw qualities of Okinawan native Agu pig sperm frozen in an extender supplemented with antiapoptotic PTD-FNK protein. (2012) (6)
Multiple cranial mononeuropathies with acetylcholine receptor antibody in mitochondrial diabetes. (2003) (6)
Influence of alcohol intake and aldehyde dehydrogenase 2 phenotype on peripheral neuropathy of diabetes. (2003) (6)
Green fluorescent protein causes mitochondria to aggregate in the presence of the Bcl-2 family proteins. (2004) (6)
Continuous culture of novel mitochondrial cells lacking nuclei. (2003) (6)
STRUCTURAL FLUCTUATION OF PROTEIN AND THERMOPHILY (1978) (5)
Maternal inheritance of diabetes is associated with inactive ALDH2 genotype in diabetics with renal failure in Japanese. (2003) (5)
Gene Structure of Human Mitochondrial ATP Synthase ?-Subunit (1993) (5)
Mitochondrial tRNA(Leu(UUR)) mutation at position 3243 detected in patients with type 1 diabetes. (2005) (5)
[Roles of mitochondrial dysfunctions in Alzheimer's disease--contribution of deficiency of ALDH 2]. (2000) (5)
Multiple tumors in mitochondrial diabetes associated with tRNALeu(UUR) mutation at position 3264. (2003) (4)
An unspliced cDNA for human dihydrolipoamide succinyltransferase: characterization and mapping of the gene to chromosome 14q24.2-q24.3. (1993) (4)
Decreased Expression of Bcl‐x Protein during Hepatocarcinogenesis Induced Exogenously and Endogenously in Rats (2001) (4)
Development of Hydrogen Medicine and Biology: Potential for Various Applications in Diverse Fields. (2021) (4)
Mitochondrial tRNALeu(UUR) mutation at position 3243 detected in patients with type 1 diabetes (2005) (4)
Molecular hydrogen as a novel antioxidant: Overviews of the advantages of hydrogen for medical applications (2015) (4)
Practicable recovery of plasmids carrying cDNAs encoding anti-apoptotic factors that had been introduced by particle bombardment into 5-week-old rat hippocampal slices (1999) (4)
Localization of Bcl‐xβ in the developing and adult rat central nervous system (2000) (3)
Diabetic vasculopathy and alcohol tolerance trait in type 2 diabetes. (2003) (3)
Cisplatin selects short forms of the mitochondrial DNA OriB variant (16184–16193 poly-cytosine tract), which confer resistance to cisplatin (2017) (3)
Hydrogenized Water Effects on Protection of Brain Cells from Oxidative Stress and Glutamate Toxicity (2019) (3)
Gene structure and cell type-specific expression of the human ATP synthase alpha subunit. (1994) (3)
Aldehyde dehydrogenase 2 genotype in type 1 diabetes mellitus. (2003) (3)
1 Rapid Diffusion of Hydrogen Protects the Retina : Administration to the Eye of Hydrogen-Containing Saline in Retinal Ischemia-Reperfusion Injury (2009) (3)
Transcription of the MRP RNA gene in frog stage I oocytes requires a novel cis-element. (1994) (3)
INCREASED DENSITY OF MITOCHONDRIA ISOLATED FROM THE SKELETAL MUSCLE OF A PATIENT WITH MITOCHONDRIAL MYOPATHY (1988) (3)
Alpha 3 beta 3 complex of thermophilic ATP synthase. Catalysis without the gamma-subunit. (1989) (3)
Mitochondrial tRNA(Leu(UUR)) mutation at position 3243 and symptomatic polyneuropathy in type 2 diabetes. (2003) (3)
Cloning of a defective gene encoding the pyruvate dehydrogenase E1α subunit from a patient with its deficiency (1989) (3)
Isolation and Sequence Analysis of the Rat Dihydrolipoamide Succinyltransferase Gene (2002) (3)
Effects of Hydrogenized Water on Intracellular Biomarkers for Antioxidants, Glucose Uptake, Insulin Signaling and SIRT 1 and Telomerase Activity (2019) (3)
PstI fragment polymorphism in the gene of the human ATP synthase beta subunit (1987) (2)
Expression of Bcl-2 on leukocytes in prostatic fluid from patients with acute and chronic prostatitis (2003) (2)
Isolation of a cDNA clone for human cytochrome c1 from a lambda gt11 expression library. (1987) (2)
Different distribution of dihydrolipoamide succinyltransferase, dihydrolipoamide acetyltransferase and ATP synthase beta-subunit in monkey brain. (1996) (2)
The alpha beta complexes of ATP synthase: the alpha 3 beta 3 oligomer and alpha 1 beta 1 protomer. (1992) (2)
[Formation of mitochondrial ATP synthesizing system and its regulation]. (1989) (2)
Molecular hydrogen may activate the transcription factor Nrf2 to alleviate oxidative stress through the hydrogen-targeted porphyrin (2023) (1)
A novel protein found in the I bands of myofibrils is produced by alternative splicing of the DLST gene. (2010) (1)
Molecular Hydrogen as an Emerging Candidate for Preventing Alzheimer’s Disease (2018) (1)
[Protein transduction and protection of cells against apoptosis]. (2004) (1)
In vitro mutated beta subunits from the F1-ATPase of the thermophilic bacterium, PS3, containing glutamine in place of glutamic acid in positions 190 or 201 assembles with the alpha and gamma subunits to produce inactive complexes. (1987) (1)
Mitochondria and the aging process. (2016) (1)
The Structure and Expression of a Human Gene for a Nuclear-Coded Mitochondrial Adenosine Triphosphate Synthase Beta Subunit (1989) (1)
Biotechnological applications of thermophilic ATP synthase: membrane electronics and genetics☆ (1989) (1)
Energy Transduction in H+-ATPase (1981) (1)
Localization of Bcl-xbeta in the developing and adult rat central nervous system. (2000) (1)
Long-Term Inhalation of Hydrogen Gas for Patients with Advanced Alzheimer's Disease: A Case Report Showing Improvement in Fecal Incontinence (2022) (1)
Biochemistry of mitochondria, life and intervention 2010. (2012) (1)
The Super Anti-Apoptotic Factor Bcl-xFNK: A Novel Mutant of Rat Bcl-Xl with a Gain-of-Function Phenotype (2001) (1)
Identification of a Gene for the Pyruvate Dehydrogenase E1α Subunit with a Deletion of Four Nucleotides from a Patient with Pyruvate Dehydrogenase Complex Deficiency (1989) (1)
The α1β1 Heterodimer and Molecular Assembly of ATP synthase (1991) (1)
S10.4 Mild uncoupling reduces oxidative stress in intact cells (2008) (0)
Stability of Mitochondrial tRNA Molecules with Pathogenic Point Mutations. (1998) (0)
The alpha 1 beta 1 heterodimer of ATP synthase. (1990) (0)
Wobble modification defect suppresses translational activity of tRNAs with MERRF and MELAS mutations. (2002) (0)
Gene Structure and Function of Thermophilic ATP Synthase (1989) (0)
[Functional alteration of mitochondrial enzymes in Alzheimer's brain]. (2000) (0)
Status of Research Funded by the American Diabetes Association — Year 4 I n 1998 (2003) (0)
Model of Cardiac Arrest, Independent of Targeted Temperature Management Hydrogen Inhalation During Normoxic Resuscitation Improves Neurological Outcome in a Rat (2014) (0)
Formation and Function of Energy-transducing Biomembranes:The roles played by chaperonin and gene. (1991) (0)
The alpha 3 beta 3 and alpha 1 beta 1 complexes of ATP synthase. (1992) (0)
Construction and large-scale culture of cybrid cells. (in Japanese) (2001) (0)
MODIFIED CDNA OF bcl-x GENE RAT AND MODIFIED PROTEIN (2000) (0)
In vivo recording of epidermal stem cell redox state (2017) (0)
Clinical pictures associated with borderline heteroplasmy rate of 3243 mitochondrial tRNA Leu (UUR) mutation in type 2 diabetes (2016) (0)
Time-lag combination therapy for cerebral ischemia using the FNK protein transduction technology and an immunosuppressant, II: In vitro study (2005) (0)
[Gene therapy and protein therapy for mitochondrial diseases]. (2002) (0)
95 Fluctuations in the Blood Prolactin Levels and TRH Loading Test Classified According to Ovarian Stimulation Methods in in Vitro Fertilization and Embryo Trasfer (1991) (0)
Suppression of autoxidation of linoleic acid-film by H2 gas. (2016) (0)
Taurine ameliorates mitochondrial dysfunction and prevents stroke-like episodes in patients with MELAS (2013) (0)
Abstract 14562: First-in-human Pilot Study of Hydrogen Gas Inhalation for Treatment of Post-cardiac Arrest Syndrome (2016) (0)
Yoshitomo Ishibashi and Shigeo Ohta induction of heat shock protein 70 GOT and liver caspase-3 of rats exposed to stress by Endurance exercise training inhibits activity of plasma (2003) (0)
Asian specific genetic variants of ALDH2 and ADH2 as risks for Alzheimer's disease and Cerebral infarction (2005) (0)
Transgenic type2 diabetes mouse models for in vivo redox measurement of hepatic mitochondrial oxidative stress. (2022) (0)
[Development of the protein therapeutics using the super anti-cell death factor FNK]. (2003) (0)
Taurine for preventing stroke-like episodes in melas, the first-ever trna modification disorder (2017) (0)
P3-365 Role of mitochondrial aldehyde dehydrogenase in the onset of Alzheimer’s disease (2006) (0)
OE-329 Novel Anti-Cell Death Protein (FNK) Therapy Preserves Myocardium Through Angiogenesis Mechanism After Myocardial Infarction in Swine(Regeneration (angionenesis/myocardial regeneration)-2 (M) OE55,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circul (2006) (0)
Consumption of Hydrogen Water Prevents the Age-dependent Impairment in Learning and Memory Tasks in AD Model Mice (2010) (0)
INACTIVE ALDEHYDE DEHYDROGENASE 2 IS AN INDEPENDENT RISK OF PANCREATIC CANCER IN A JAPANESE POPULATION (2006) (0)
Neuroprotective therapy in acute cerebral ischemia (2004) (0)
Blue light-induced oxidative stress in mouse and human live skin (2016) (0)
Analysis of mechanisms of fatty acid metabolism induced by molecular hydrogen in diabetes model mice. (2016) (0)
Brain protection therapy on cerebral infarction (2014) (0)
PE-436 Hydrogen Gas Protects Cardiomyocyte Cell Death and Reduces the Infarct Size in the Rat Model of Myocardial Ischemia-Reperfusion Injury(PE073,Myocardial Ischemia-reperfusion (Basic) (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation Society) (2009) (0)
Multi-functional molecular hydrogen acting as an anti-oxidant, anti-inflammation and energy metabolism-stimulator (2013) (0)
Mitochondrial Myopathy and Transcriptional Control (1992) (0)
[Transfection of mitochondrial genes converted to universal codons into the nucleus]. (2005) (0)
Aggregation of mitochondria. (2005) (0)
G.O.19 Taurine supplemental therapy in prevention of stroke-like episodes in MELAS (2015) (0)
In vivo analysis of redox state in type 2 diabetes model mice. (2017) (0)
P4-247 Deficiency in a mitochondrial aldehyde dehydrogenase promotes oxidative stress and the onset of Alzheimer's disease (2004) (0)
P2-451: Hydrogen acts as a therapeutic antioxidant in brain ischemia and restores learning and memory deficits declined by physical restraint stress (2008) (0)
Response to Letter Regarding Article, "Hydrogen Inhalation During Normoxic Resuscitation Improves Neurological Outcome in a Rat Model of Cardiac Arrest Independently of Targeted Temperature Management". (2015) (0)
[The origin of mitochondria]. (2002) (0)
Abstract 210: Inhalation of H2 Gas Starting After Resuscitation Under Normoxia Improves Neurological Outcomes in a Rat Cardiac Arrest Model (2014) (0)
Kinases-dependent metabolic shift towards the Phgdh-mediated serine synthesis enhances cardioprotection to oxidative stress as hormesis to aldehydes (2008) (0)
Abstract 12746: Hydrogen Inhalation Improves Neurological and Cardiac Outcome in a Rat Model of Cardiac Arrest With Ventricular Fibrillation (2012) (0)
Identification of differentially expressed genes in post-cardiac arrest syndrome treated with H2 inhalation in rats: A DNA microarray study (2019) (0)
Abstract 353: Genetic Mutation of ALDH2 Enhances Cardiomyocyte Tolerance to Oxidative Stress as a Result of Hormetic Response to Aldehydes (2007) (0)
Abstract 1394: Sublethal Levels of Aldehydes Augmented Cardiac Anti-Oxidant Defense through Activation of eIF2{alpha}-ATF4 Pathway via GCN2 Kinase (2008) (0)
Mutations in the ATP synthase gene suppress the lethal effect by human Bax against bacteria (1998) (0)
[Genetic diagnosis of mitochondrial diseases]. (1995) (0)
Future Directions in Hydrogen Studies (2015) (0)
Consumption of hydrogen water prevents age-dependent memory impairment accompanying neurodegeneration in Alzheimer's model mice (2011) (0)
Time-lag combination therapy for cerebral ischemia using the FNK protein transduction technology and an immunosuppressant, I: In vivo study (2005) (0)
Childhood Cancer and Neural Tube Defects (2006) (0)
Hydrogen Element and Hydrogen Gas (2015) (0)
Mitochondrial disease linked to modification defect at mitochondrial tRNA wobble nucleotide. (in Japanese) (2000) (0)
Combination therapy with transductive anti‐death FNK protein and FK506 ameliorates brain damage with focal transient ischemia in rat (2008) (0)
Mitochondrial disease and tRNA. (in Japanese) (2000) (0)
RAT BCL-XL AN APOPTOSIS INHIBITORY PROTEIN (1997) (0)
[Molecular mechanism of regulation of apoptosis and related diseases]. (1996) (0)
[Apoptosis and its related diseases. Introduction for the symposium]. (1997) (0)
[Prospect for the technology manipulating mtDNA]. (2005) (0)
MOLECULAR PATHOLOGY OF MITOCHONDRIAL DISEASES (1999) (0)
[Assay of biochemical activity (respiratory complex activity, pyruvate dehydrogenase complex activity etc)for diagnosis of mitochondrial diseases]. (2002) (0)
Various morphologies of mitochondria. (2005) (0)
Genetic analysis and clinical application in polygenic diseases (1999) (0)
G.O.17 MELAS, a first-ever tRNA modification disorder is alleviated by taurine supplementation therapy (2016) (0)
Protective effect of physical exercise on stress-induced impairment of spatial memory is dependent on IGF-1 (2008) (0)
Gene Structure of Human ATP Synthase Beta Subunit (1990) (0)
Defective Gene in Lactic Acidosis: Abnormal Pyruvate (2006) (0)
Hydrogen-Loaded Eye Drops Suppress Progression of Keratoconus-Like Corneal Lesion of SKC Mouse (2013) (0)
[Involvement of somatic mutations in mtDNA with aging, cancer and apoptosis]. (2005) (0)
Neuroprotecting Mechanisms of Ischemic Preconditioning (2006) (0)
[Mitochondrial tRNA diseases: defect of modification in anticodon in mutant tRNA molecules]. (2003) (0)
[Mitochondrial diseases caused by mitochondrial DNA mutants and their related regulation of mitochondrial biogenesis]. (1995) (0)
Protective Effect of Hydrogen in Retinal Ischemia-Reperfusion Injury (2008) (0)
Pore-Forming Structure and Bifunction of the Pro-Apoptotic Factor, Bax (1999) (0)

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What Schools Are Affiliated With Shigeo Ohta?

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