Shigeomi Shimizu
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Shigeomi Shimizucomputer-science Degrees
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Computational Linguistics
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Computer Science
Shigeomi Shimizu's Degrees
- PhD Computer Science University of Tokyo
- Masters Computer Science University of Tokyo
- Bachelors Computer Science University of Tokyo
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(Suggest an Edit or Addition)Shigeomi Shimizu's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012) (2913)
- Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC (1999) (2234)
- Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes (2004) (1439)
- Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death (2005) (1272)
- Intracellular ATP levels determine cell death fate by apoptosis or necrosis. (1997) (1268)
- Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria. (1998) (998)
- Autophagy mediates the mitotic senescence transition. (2009) (962)
- Discovery of Atg5/Atg7-independent alternative macroautophagy (2009) (861)
- Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 (2021) (811)
- Another way to die: autophagic programmed cell death (2005) (756)
- Bcl‐2 family: Life‐or‐death switch (2000) (699)
- Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL (1995) (631)
- JNK promotes Bax translocation to mitochondria through phosphorylation of 14‐3‐3 proteins (2004) (555)
- Role of the mitochondrial membrane permeability transition in cell death (2007) (540)
- Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes (2011) (471)
- Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating proton flux. (1998) (428)
- BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death. (2000) (406)
- Induction of apoptosis as well as necrosis by hypoxia and predominant prevention of apoptosis by Bcl-2 and Bcl-XL. (1996) (387)
- Essential Role of Voltage-Dependent Anion Channel in Various Forms of Apoptosis in Mammalian Cells (2001) (373)
- Hypertrophy and Unconventional Cell Division of Hepatocytes Underlie Liver Regeneration (2012) (349)
- 14-3-3 Interacts Directly with and Negatively Regulates Pro-apoptotic Bax* (2003) (347)
- Electrophysiological Study of a Novel Large Pore Formed by Bax and the Voltage-dependent Anion Channel That Is Permeable to Cytochrome c * (2000) (345)
- Bcl-2 blocks loss of mitochondrial membrane potential while ICE inhibitors act at a different step during inhibition of death induced by respiratory chain inhibitors. (1996) (329)
- VDAC regulation by the Bcl-2 family of proteins (2000) (327)
- Involvement of Histone H1.2 in Apoptosis Induced by DNA Double-Strand Breaks (2003) (305)
- Proapoptotic BH3-only Bcl-2 family members induce cytochrome c release, but not mitochondrial membrane potential loss, and do not directly modulate voltage-dependent anion channel activity. (2000) (289)
- Retardation of chemical hypoxia-induced necrotic cell death by Bcl-2 and ICE inhibitors: possible involvement of common mediators in apoptotic and necrotic signal transductions. (1996) (278)
- Bcl-2 expression prevents activation of the ICE protease cascade. (1996) (271)
- Structural Divergence of Human Ghrelin (2003) (264)
- Fzo1, a Protein Involved in Mitochondrial Fusion, Inhibits Apoptosis* (2004) (254)
- The voltage-dependent anion channel: an essential player in apoptosis. (2002) (252)
- Gelsolin Inhibits Apoptosis by Blocking Mitochondrial Membrane Potential Loss and Cytochrome c Release* (2000) (232)
- Ceramide Formation Leads to Caspase-3 Activation during Hypoxic PC12 Cell Death (1998) (209)
- Mitochondrial membrane permeability transition and cell death. (2006) (189)
- ATP-dependent steps in apoptotic signal transduction. (1999) (177)
- Bcl-2 Prevents Caspase-independent Cell Death* (1998) (171)
- Autophagic Cell Death and Cancer (2014) (170)
- Involvement of CPP32/Yama(-like) proteases in Fas-mediated apoptosis. (1996) (169)
- Bax and Bcl-xL independently regulate apoptotic changes of yeast mitochondria that require VDAC but not adenine nucleotide translocator (2000) (165)
- Ulk1-mediated Atg5-independent macroautophagy mediates elimination of mitochondria from embryonic reticulocytes (2014) (164)
- Mitochondrial permeability transition mediates apoptosis induced by N‐methyl(R)salsolinol, an endogenous neurotoxin, and is inhibited by Bcl‐2 and rasagiline, N‐propargyl‐1(R)‐aminoindan (2002) (160)
- Involvement of JNK in the regulation of autophagic cell death (2010) (160)
- Human gelsolin prevents apoptosis by inhibiting apoptotic mitochondrial changes via closing VDAC (2000) (141)
- Apoptotic cytosol facilitates Bax translocation to mitochondria that involves cytosolic factor regulated by Bcl-2. (1999) (141)
- Bcl-2/E1B 19 kDa-interacting protein 3-like protein (Bnip3L) interacts with Bcl-2/Bcl-xL and induces apoptosis by altering mitochondrial membrane permeability (1999) (130)
- Activation of mitochondrial voltage-dependent anion channel by apro-apoptotic BH3-only protein Bim (2002) (128)
- Inhibition of apoptosis by the actin‐regulatory protein gelsolin (1997) (124)
- Bcl-2 and Bcl-xL block apoptosis as well as necrosis: possible involvement of common mediators in apoptotic and necrotic signal transduction pathways. (1997) (113)
- Association Between Autophagy and Neurodegenerative Diseases (2018) (113)
- Antiapoptotic function of 17AA(+)WT1 (Wilms' tumor gene) isoforms on the intrinsic apoptosis pathway (2006) (113)
- Opening of plasma membrane voltage-dependent anion channels (VDAC) precedes caspase activation in neuronal apoptosis induced by toxic stimuli (2005) (112)
- BH4-domain peptide from Bcl-xL exerts anti-apoptotic activity in vivo (2003) (109)
- Molecular mechanisms and physiological roles of Atg5/Atg7-independent alternative autophagy (2017) (103)
- Shigella targets epithelial tricellular junctions and uses a noncanonical clathrin-dependent endocytic pathway to spread between cells. (2012) (101)
- Direct thioamination of arynes via reaction with sulfilimines and migratory N-arylation. (2015) (84)
- Intrinsic Autophagy Is Required for the Maintenance of Intestinal Stem Cells and for Irradiation-Induced Intestinal Regeneration. (2017) (81)
- Nerve growth factor suppresses apoptosis of murine neutrophils. (1992) (78)
- Furanonaphthoquinones cause apoptosis of cancer cells by inducing the production of reactive oxygen species by the mitochondrial voltage-dependent anion channel (2006) (73)
- Prevention of hypoxic liver cell necrosis by in vivo human bcl-2 gene transfection. (1998) (67)
- Cancer gene therapy using a pro-apoptotic gene, caspase-3 (1999) (67)
- Involvement of ICE family proteases in apoptosis induced by reoxygenation of hypoxic hepatocytes. (1996) (67)
- Role of Atg5-dependent cell death in the embryonic development of Bax/Bak double-knockout mice (2017) (66)
- HMGB1 facilitates repair of mitochondrial DNA damage and extends the lifespan of mutant ataxin-1 knock-in mice (2014) (63)
- Golgi membrane‐associated degradation pathway in yeast and mammals (2016) (63)
- Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming (2019) (62)
- Identification of PPM1D as an essential Ulk1 phosphatase for genotoxic stress‐induced autophagy (2016) (62)
- xCT deficiency accelerates chemically induced tumorigenesis (2010) (59)
- Live Cell Imaging of Mitochondrial Autophagy with a Novel Fluorescent Small Molecule. (2017) (59)
- Crystal structure of human cyclophilin D in complex with its inhibitor, cyclosporin A at 0.96‐Å resolution (2007) (56)
- BH 4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death (2000) (55)
- Requirement of voltage-dependent anion channel 2 for pro-apoptotic activity of Bax (2009) (53)
- Death‐signalling cascade in mouse cerebellar granule neurons (1998) (52)
- The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function (2018) (51)
- The stent-eluting drugs sirolimus and paclitaxel suppress healing of the endothelium by induction of autophagy. (2009) (50)
- Small fluorescent molecules for monitoring autophagic flux (2018) (47)
- Transformation of an antimicrobial peptide into a plasma membrane-permeable, mitochondria-targeted peptide via the substitution of lysine with arginine. (2012) (47)
- BH4 peptide derivative from Bcl-xL attenuates ischemia/reperfusion injury thorough anti-apoptotic mechanism in rat hearts. (2005) (47)
- Permeability transition-independent release of mitochondrial cytochrome c induced by valinomycin. (2002) (46)
- Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase-mediated antiviral response (2017) (43)
- New method for measuring ICG Rmax with a clearance meter (2004) (41)
- Bcl-2 protects tubular epithelial cells from ischemia/reperfusion injury by dual mechanisms. (2009) (40)
- Biological Roles of Alternative Autophagy (2018) (39)
- The targeting of cyclophilin D by RNAi as a novel cardioprotective therapy: evidence from two-photon imaging. (2009) (37)
- Omi / HtrA2 is relevant to the selective vulnerability of striatal neurons in Huntington’s disease (2008) (36)
- A mild and facile synthesis of aryl and alkenyl sulfides via copper-catalyzed deborylthiolation of organoborons with thiosulfonates. (2015) (35)
- A Bax/Bak-independent Mechanism of Cytochrome c Release* (2007) (34)
- Identification of a phosphorylation site on Ulk1 required for genotoxic stress-induced alternative autophagy (2020) (34)
- Autophagy takes an alternative pathway (2010) (33)
- Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356 (2016) (33)
- In Situ Characterization of Bak Clusters Responsible for Cell Death Using Single Molecule Localization Microscopy (2016) (32)
- Editorial :Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). DOI: 10.1080/15548627.2015.1100356;WOS:000373595400001; 2-s2.0-85013763791&;PMID: 26799652 (2016) (31)
- Involvement of Beclin 1 in Engulfment of Apoptotic Cells* (2012) (30)
- Autophagy controls centrosome number by degrading Cep63 (2016) (29)
- Bcl-2 Protects Tubular Epithelial Cells from Ischemia Reperfusion Injury by Inhibiting Apoptosis (2008) (27)
- Paraquat Toxicity Induced by Voltage-dependent Anion Channel 1 Acts as an NADH-dependent Oxidoreductase* (2009) (27)
- Delayed‐onset caspase‐dependent massive hepatocyte apoptosis upon fas activation in bak/bax‐deficient mice (2011) (26)
- Rhodium-catalyzed odorless synthesis of diaryl sulfides from borylarenes and S-aryl thiosulfonates. (2017) (24)
- Dram1 regulates DNA damage-induced alternative autophagy (2018) (24)
- Preparation of connexin43‐integrated giant Liposomes by a baculovirus expression–liposome fusion method (2010) (23)
- ENZYME RELEASE FROM MITOCHONDRIA DURING REOXYGENATION OF RAT LIVER (1994) (23)
- 14-3-3 interacts directly with and negatively regulates pro-apoptotic Bax. (2015) (22)
- Identification of a novel compound that inhibits both mitochondria-mediated necrosis and apoptosis. (2015) (21)
- The role of Cyclophilin D in learning and memory (2009) (21)
- Chk2 regulates transcription-independent p53-mediated apoptosis in response to DNA damage. (2005) (20)
- Inhibition of the 53BP2S‐mediated apoptosis by nuclear factor κB and Bcl‐2 family proteins (2005) (20)
- Hyperoxidation of ether-linked phospholipids accelerates neutrophil extracellular trap formation (2017) (20)
- Wipi3 is essential for alternative autophagy and its loss causes neurodegeneration (2020) (19)
- Autophagy suppresses cell migration by degrading GEF-H1, a RhoA GEF (2016) (19)
- Alternative macroautophagy and mitophagy. (2014) (19)
- correction: BcL-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC (2000) (18)
- A Caspase-8-independent Signaling Pathway Activated by Fas Ligation Leads to Exposure of the Bak N Terminus* (2004) (18)
- ER-resident sensor PERK is essential for mitochondrial thermogenesis in brown adipose tissue (2020) (17)
- Ca2+ release from mitochondria induces cytosolic enzyme leakage in anoxic liver. (1995) (17)
- TRF2 Protein Interacts with Core Histones to Stabilize Chromosome Ends* (2016) (16)
- Organelle zones in mitochondria. (2018) (15)
- Improvement of rat liver graft function by insulin administration to donor. (1996) (15)
- Autophagic Cell Death and Cancer Chemotherapeutics (2015) (14)
- Changes in biliary glutathione level during ischemia-reperfusion of rat liver. (1994) (14)
- Beclin 1 regulates recycling endosome and is required for skin development in mice (2019) (13)
- Simultaneous surgery for coronary artery disease and gastric cancer (1994) (13)
- Inhibition of epithelial cell death by Bcl-2 improved chronic colitis in IL-10 KO mice. (2013) (12)
- Association between Atg5-independent alternative autophagy and neurodegenerative diseases. (2020) (12)
- [Development of anti-cancer drugs mediated by apoptosis and autophagy]. (2015) (12)
- Neurodegeneration in mnd2 mutant mice is not prevented by parkin transgene. (2010) (12)
- Corrigendum: Discovery of Atg5/Atg7-independent alternative macroautophagy (2016) (12)
- Budd-Chiari Syndrome Combined With Antiphospholipid Syndrome: Case Report and Literature Review (1993) (11)
- Oxidized Phospholipids and Neutrophil Elastase Coordinately Play Critical Roles in NET Formation (2021) (10)
- Sanguisorba officinalis L. derived from herbal medicine prevents intestinal inflammation by inducing autophagy in macrophages (2020) (10)
- Global Liver Gene Expression Analysis on a Murine Metabolic Syndrome Model Treated by Low-molecular-weight Lychee Fruit Polyphenol (Oligonol®). (2016) (10)
- Ohtsu, M. et al. Inhibition of apoptosis by the actin-regulatory protein gelsolin. EMBO J. 16, 4650-4656 (1997) (9)
- Structures of the Small-Molecule Bcl-2 Inhibitor (BH3I-2) and Its Related Simple Model in Protonated and Deprotonated Forms (2004) (9)
- Cyclophilin D-dependent mitochondrial permeability transition is not involved in neurodegeneration in mnd2 mutant mice. (2010) (8)
- Homeostatic p62 levels and inclusion body formation in CHCHD2 knockout mice. (2021) (8)
- Mitochondrial E3 Ubiquitin Ligase Parkin: Relationships with Other Causal Proteins in Familial Parkinson’s Disease and Its Substrate-Involved Mouse Experimental Models (2020) (7)
- p53 inhibits vascular endothelial growth factor expression in solid tumor. (2012) (7)
- HMGB 1 facilitates repair of mitochondrial DNA damage and extends the lifespan of mutant ataxin-1 knockin mice (2014) (7)
- [Molecular biology of apoptosis]. (1997) (6)
- Requirement of voltage-dependent anion channel 2 for pro-apoptotic activity of Bax (2010) (6)
- Hypoxia-reoxygenation causes DNA damage in hepatocytes. (1994) (5)
- Autophagy involvement in oncogenesis (2020) (5)
- The ceramide analogue N-(1-hydroxy-3-morpholino-1-phenylpropan-2-yl)decanamide induces large lipid droplet accumulation and highlights the effect of LAMP-2 deficiency on lipid droplet degradation. (2019) (5)
- [Molecular mechanism of apoptosis]. (1998) (5)
- Prevention of hypoxic liver injury by in vivo transfection of the human bcl-2 gene. (1997) (5)
- Autophagy controls centrosome number (2017) (4)
- Crystal structure of human cyclophilin D in complex with cyclosporin A (2008) (4)
- Two distinct Fas-activated signaling pathways revealed by an antitumor drug D609 (2005) (4)
- Beclin 1 regulates recycling endosome and is required for skin development in mice (2019) (4)
- Enhancement of glycolysis in preserved rat liver: correlation between insulin procurement and phosphofructo-1-kinase activity. (1995) (4)
- Molecular mechanisms and biological roles of GOMED (2021) (3)
- Ischemic liver injury induced by calcium released from mitochondria. (1992) (3)
- Protective effects of feeding and of fructose against hypoxic damage in the perfused liver. (1994) (3)
- [Molecular mechanisms of DNA damage-induced apoptosis]. (2006) (2)
- [Apoptosis and non-apoptotic cell death]. (2011) (2)
- Nickel particles are present in Crohn's disease tissue and exacerbate intestinal inflammation in IBD susceptible mice. (2022) (2)
- The 3rd German-Japanese Joint Workshop. Cell Death in the CNS: Molecules and Programs (1996) (2)
- Involvement of phosphorylation of ULK1 in alternative autophagy. (2020) (2)
- Alternative autophagy plays a central role in mitochondria elimination from reticulocytes. (2017) (1)
- PROTECTION OF MITOCHONDRIAL POTENTIAL LOSS BY BCL-2 IN APOPTOSIS AND NECROSIS (1996) (1)
- A CASE REPORT OF GIANT HEPATOCELLULAR CARCINOMA WHICH WAS DIFFICULT TO DIFFERENTIALLY DIAGNOSE FROM HEPATIC HEMANGIOMA (1994) (1)
- A Case Report of Multiple Cancers in Colon and Rectum Accompanied with Gastric Cancer. (1991) (1)
- BH4 merged polypeptide (2000) (0)
- 4 and other hand , the Bcl-2 proto-oncogene product ( Bakhshi (2013) (0)
- [X-ray-induced DNA damage and apoptosis]. (2004) (0)
- Hyperoxidation of ether-linked phospholipids accelerates neutrophil extracellular trap formation (2017) (0)
- Percutaneous transluminal angioplasty for re-stenosis after radical reconstructive operation for Budd-Chiari syndrome: Report of 2 cases. (1988) (0)
- Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming (2019) (0)
- FLIP-based autophagy-detecting technique reveals closed autophagic compartments (2022) (0)
- Analysis of anoikis in non-apoptotic cell death (2017) (0)
- Alternative autophagy pathways conserved from yeast to mammals Features of TMDU Research (2017) (0)
- Effect of intracellular pH on reoxygenation-induced mitochondrial damage. (1995) (0)
- [Nomenclature on Cell Death, apoptosis and autophagic cell death.] (2019) (0)
- Identification of a novel type of focal adhesion remodelling via FAK/FRNK replacement, and its contribution to cancer progression (2023) (0)
- Multicentric Carcinoma in situ Occurring in a Villous Adenoma of the Appendix (1991) (0)
- FLOW-CYTOMETRIC ANALYSIS OF DNA PLOIDY IN 20 CASES OF SMOOTH-MUSCLE TUMOR OF GASTRODUODENAL ORIGIN (1992) (0)
- The role of the Atg5/Atg7-independent autophagy in the brain (2016) (0)
- Identification of non-apoptotic anoikis (2016) (0)
- Pro-apoptotic actions of 53BP2 in a human pancreatic cancer cell line (2000) (0)
- Prediction of intracellular targets of a small compound by analyzing peptides presented on MHC class I. (2019) (0)
- Monitoring of Atg5-Independent Mitophagy. (2018) (0)
- Analysis of AAG3 in alternative autophagy pathway (2016) (0)
- Absence of ULK1 decreases AMPK activity in the kidney, leading to chronic kidney disease progression (2022) (0)
- [Drugs that activates apoptosis]. (2012) (0)
- Inhibition of Insulin Secretion Induces Golgi Morphological Changes (2023) (0)
- Analysis of Aag3 in alternative autophagy (2017) (0)
- The role of PPM1D molecule in regulating DNA damage-induced autophagy (2016) (0)
- Chemical Screening of Alternative Autophagy Specific Inducer (2017) (0)
- Contents list. (2017) (0)
- BCL-2 PROTECTS TUBULAR EPITHELIAL CELLS FROM ISCHEMIA REPERFUSION INJURY VIA DUAL MECHANISMS: 1750 (2008) (0)
- Regulation of DNA damage-induced apoptosis by autophagy (2017) (0)
- TOR autophagy spatial coupling compartment (TASCC) augments secretory phenotypes (2011) (0)
- Involvement of ICE-like proteases in hypoxic cell death. (1996) (0)
- Visualization of Autophagy with Fluorescent Small Molecules; Live Cell Imaging of Mitophagy and Autolysosome (2017) (0)
- [gp-130 related cytokines in mechanisms of myeloma cell growth]. (1997) (0)
- [Cell division mechanism of multiple myeloma]. (1995) (0)
- Ischemic liver injury by calcium released from mitochondria (1992) (0)
- Autophagy researchers (2013) (0)
- Acute Chromium Intoxication Caused by Chromic Acid Burns (1990) (0)
- Mammalian Autophagy Can Occur Through an Atg5/Atg7-Independent Pathway (2014) (0)
- Identification of a phosphorylation site on Ulk1 required for genotoxic stress-induced alternative autophagy (2020) (0)
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What Schools Are Affiliated With Shigeomi Shimizu?
Shigeomi Shimizu is affiliated with the following schools:
