Shimon Schuldiner
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Physics
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(Suggest an Edit or Addition)Shimon Schuldiner's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- A cDNA that suppresses MPP+ toxicity encodes a vesicular amine transporter (1992) (583)
- Determination of ΔpH in Chloroplasts (1972) (545)
- Mechanism of Transport and Storage of Neurotransmitter (1987) (409)
- EmrE, an Escherichia coli 12-kDa Multidrug Transporter, Exchanges Toxic Cations and H+ and Is Soluble in Organic Solvents (*) (1995) (313)
- pH homesstasis in bacteria (1981) (309)
- Vesicular neurotransmitter transporters: from bacteria to humans. (1995) (308)
- Membrane potential and active transport in membrane vesicles from Escherichia coli. (1975) (254)
- Overproduction and purification of a functional Na+/H+ antiporter coded by nhaA (ant) from Escherichia coli. (1991) (235)
- Na+/H+ antiport in Swiss 3T3 cells: mitogenic stimulation leads to cytoplasmic alkalinization. (1982) (227)
- The electrochemical gradient of protons and its relationship to active transport in Escherichia coli membrane vesicles. (1976) (216)
- Three‐dimensional structure of the bacterial multidrug transporter EmrE shows it is an asymmetric homodimer (2003) (215)
- Escherichia coli intracellular pH, membrane potential, and cell growth (1984) (205)
- A membrane‐embedded glutamate is required for ligand binding to the multidrug transporter EmrE (2000) (197)
- pH homeostasis in bacteria. (1981) (194)
- Mechanism of transport and storage of neurotransmitters. (1987) (192)
- Characterization of a Na+/H+ antiporter gene of Escherichia coli. (1987) (191)
- Cloning and characterization of a putative Ca2+/H+ antiporter gene from Escherichia coli upon functional complementation of Na+/H+ antiporter-deficient strains by the overexpressed gene. (1993) (187)
- A coordinated network of transporters with overlapping specificities provides a robust survival strategy (2009) (175)
- Physiological role of nhaB, a specific Na+/H+ antiporter in Escherichia coli. (1993) (166)
- Deletion of ant in Escherichia coli reveals its function in adaptation to high salinity and an alternative Na+/H+ antiporter system(s). (1989) (163)
- Proton electrochemical gradient in Escherichia coli cells and its relation to active transport of lactose. (1979) (161)
- A Molecular Glimpse of Vesicular Monoamine Transporters (1994) (152)
- EmrE, a model for studying evolution and mechanism of ion-coupled transporters. (2009) (151)
- Amphetamine derivatives interact with both plasma membrane and secretory vesicle biogenic amine transporters. (1993) (148)
- An Essential Glutamyl Residue in EmrE, a Multidrug Antiporter from Escherichia coli * (2000) (142)
- Proton-sodium stoichiometry of NhaA, an electrogenic antiporter from Escherichia coli. (1993) (141)
- In vitro synthesis of fully functional EmrE, a multidrug transporter, and study of its oligomeric state. (2004) (141)
- Molecular physiology of Na+/H+ antiporters, key transporters in circulation of Na+ and H+ in cells. (1994) (140)
- Sodium-proton antiport in isolated membrane vesicles of Escherichia coli. (1978) (134)
- The projection structure of EmrE, a proton‐linked multidrug transporter from Escherichia coli, at 7 Å resolution (2001) (131)
- Histidine-226 is part of the pH sensor of NhaA, a Na+/H+ antiporter in Escherichia coli. (1993) (124)
- Projection structure of NhaA, a secondary transporter from Escherichia coli, at 4.0 Å resolution (1999) (124)
- Negative Dominance Studies Demonstrate the Oligomeric Structure of EmrE, a Multidrug Antiporter from Escherichia coli* (1996) (122)
- Mutants of the Bacillus subtilis multidrug transporter Bmr with altered sensitivity to the antihypertensive alkaloid reserpine. (1993) (120)
- Cloning, sequencing, and expression of the nhaB gene, encoding a Na+/H+ antiporter in Escherichia coli. (1992) (118)
- Sequencing of the gene ant which affects the Na+/H+ antiporter activity in Escherichia coli. (1988) (115)
- Structural conservation in the major facilitator superfamily as revealed by comparative modeling (2004) (111)
- Scanning Cysteine Accessibility of EmrE, an H+-coupled Multidrug Transporter from Escherichia coli, Reveals a Hydrophobic Pathway for Solutes* (1999) (108)
- The sodium/proton antiporter is part of the pH homeostasis mechanism in Escherichia coli. (1982) (105)
- Determination of DeltapH in Chloroplasts. 2. Fluorescent Amines as a Probe for the Determination of DeltapH in Chloroplasts (1972) (99)
- Determining the secondary structure and orientation of EmrE, a multi-drug transporter, indicates a transmembrane four-helix bundle. (1996) (96)
- Expression of a sodium proton antiporter (NhaA) in Escherichia coli is induced by Na+ and Li+ ions. (1991) (93)
- Crosslinking of membrane-embedded cysteines reveals contact points in the EmrE oligomer (2002) (91)
- A model for coupling of H(+) and substrate fluxes based on "time-sharing" of a common binding site. (2000) (90)
- NMR investigation of the multidrug transporter EmrE, an integral membrane protein. (1998) (89)
- EmrE, a Multidrug Transporter from Escherichia coli, Transports Monovalent and Divalent Substrates with the Same Stoichiometry* (2004) (88)
- NhaR, a protein homologous to a family of bacterial regulatory proteins (LysR), regulates nhaA, the sodium proton antiporter gene in Escherichia coli. (1992) (88)
- Energetics of reserpine binding and occlusion by the chromaffin granule biogenic amine transporter. (1990) (87)
- An alkaline shift induces the heat shock response in Escherichia coli (1987) (85)
- Energy transduction in the photosynthetic membranes of the cyanobacterium (blue-green alga) P-lectonema boryanum. (1978) (84)
- Na+/H+ antiporters, molecular devices that couple the Na+ and H+ circulation in cells (1993) (82)
- Direct Evidence for Substrate-induced Proton Release in Detergent-solubilized EmrE, a Multidrug Transporter* (2004) (80)
- Determination of pH in chloroplasts. 2. Fluorescent amines as a probe for the determination of pH in chloroplasts. (1972) (79)
- Reserpine binding to a vesicular amine transporter expressed in Chinese hamster ovary fibroblasts. (1993) (79)
- Mutations affecting substrate specificity of the Bacillus subtilis multidrug transporter Bmr (1997) (79)
- A common binding site for substrates and protons in EmrE, an ion‐coupled multidrug transporter (2000) (77)
- Kinetic properties of NhaB, a Na+/H+ antiporter from Escherichia coli. (1994) (77)
- Role of a transmembrane pH gradient in epinephrine transport by chromaffin granule membrane vesicles. (1978) (74)
- In Vitro Monomer Swapping in EmrE, a Multidrug Transporter from Escherichia coli, Reveals That the Oligomer Is the Functional Unit* (2001) (72)
- The pharmacological profile of the vesicular monoamine transporter resembles that of multidrug transporters (1995) (72)
- In vitro unfolding and refolding of the small multidrug transporter EmrE. (2009) (70)
- Energy-dependent binding of dansylgalactosides to the beta-galactoside carrier protein. (1975) (69)
- Induction of SOS functions by alkaline intracellular pH in Escherichia coli (1986) (69)
- A Single Carboxyl Mutant of the Multidrug Transporter EmrE Is Fully Functional* (2001) (67)
- Molecular physiology of the Na+/H+ antiporter in Escherichia coli. (1994) (66)
- An Amino Acid Cluster around the Essential Glu-14 Is Part of the Substrate- and Proton-binding Domain of EmrE, a Multidrug Transporter from Escherichia coli * (2003) (66)
- Cloning and functional expression of a tetrabenazine sensitive vesicular monoamine transporter from bovine chromaffin granules (1994) (65)
- Topologically Random Insertion of EmrE Supports a Pathway for Evolution of Inverted Repeats in Ion-coupled Transporters* (2010) (62)
- When biochemistry meets structural biology: the cautionary tale of EmrE. (2007) (62)
- Stimulation of ATP synthesis by a membrane potential in chloroplasts. (1973) (60)
- Functional Analysis of Novel Multidrug Transporters from Human Pathogens* (2001) (59)
- Reserpine as a competitive and reversible inhibitor of the catecholamine transporter of bovine chromaffin granules (1979) (59)
- The fast release of sticky protons: Kinetics of substrate binding and proton release in a multidrug transporter (2007) (59)
- Small is mighty: EmrE, a multidrug transporter as an experimental paradigm. (2001) (58)
- Evidence for two distinct serotonin transport systems in platelets. (1980) (58)
- [27] Intracellular pH regulation in bacterial cells (1986) (55)
- Identification and purification of a functional amine transporter from bovine chromaffin granules. (1990) (54)
- Substrate-induced tryptophan fluorescence changes in EmrE, the smallest ion-coupled multidrug transporter. (2005) (54)
- Topological Analysis of NhaA, a Na+/H+ Antiporter from Escherichia coli* (1996) (53)
- [74] The use of flow dialysis for determinations of ΔpH and active transport (1979) (52)
- Parallel topology of genetically fused EmrE homodimers (2008) (52)
- EmrE, the smallest ion-coupled transporter, provides a unique paradigm for structure-function studies. (1997) (51)
- On Parallel and Antiparallel Topology of a Homodimeric Multidrug Transporter* (2006) (51)
- The membrane topology of EmrE – a small multidrug transporter from Escherichia coli (2004) (50)
- The ins and outs of vesicular monoamine transporters (2018) (50)
- Identification of a Glycine Motif Required for Packing in EmrE, a Multidrug Transporter from Escherichia coli* (2008) (50)
- Identification of Tyrosine Residues Critical for the Function of an Ion-coupled Multidrug Transporter* (2006) (48)
- MH1, A Second-site Revertant of an Escherichia coli Mutant Lacking Na+/H+ Antiporters (ΔnhaAΔnhaB), Regains Na+ Resistance and a Capacity to Excrete Na+ in a Δμ̃H+-independent Fashion (*) (1995) (47)
- Characterization of an Archaeal Multidrug Transporter with a Unique Amino Acid Composition* (2003) (46)
- ΔpH and membrane potential in bacterial chromatophores (1974) (46)
- Functional asymmetry of the amine transporter from chromaffin granules. (1983) (45)
- Anion permeability of chloroplasts. (1971) (45)
- Membrane potential as a driving force for ATP synthesis in chloroplasts (1972) (44)
- Modification of the pH Profile and Tetrabenazine Sensitivity of Rat VMAT1 by Replacement of Aspartate 404 with Glutamate* (1996) (44)
- 3D model of the Escherichia coli multidrug transporter MdfA reveals an essential membrane-embedded positive charge. (2005) (44)
- Replacements of Histidine 226 of NhaA-Na+/H+ Antiporter of Escherichia coli (1995) (43)
- Exploring the Binding Domain of EmrE, the Smallest Multidrug Transporter* (2005) (41)
- On the mechanism of the energy‐dependent quenching of atebrin fluorescence in isolated chloroplasts (1971) (41)
- Homology of a vesicular amine transporter to a gene conferring resistance to 1-methyl-4-phenylpyridinium. (1992) (39)
- The role of a transmembrane pH gradient in 5‐hydroxy tryptamine uptake by synaptic vesicles from rat brain (1979) (39)
- Reversible effects of chaotropic agents on the proton permeability of Escherichia coli membrane vesicles. (1975) (38)
- A single locus in Escherichia coli governs growth in alkaline pH and on carbon sources whose transport is sodium dependent (1980) (38)
- Transforming a drug/H+ antiporter into a polyamine importer by a single mutation (2012) (38)
- Precious things come in little packages. (2001) (37)
- Solubilization and reconstitution of the catecholamine transporter from bovine chromaffin granules. (1979) (36)
- Expression and function of the rat vesicular monoamine transporter 2. (2008) (35)
- Intracellular pH and membrane potential as regulators in the prokaryotic cell (2005) (34)
- Probing the conformation of NhaA, a Na+/H+ antiporter from Escherichia coli, with trypsin. (1997) (34)
- Chapter 22 Bacterial Na+/H+ antiporters — Molecular biology, biochemistry and physiology (1996) (34)
- Zwitterionic and anionic forms of a serotonin analog as transport substrates. (1989) (34)
- Na+ gradient-coupled porters of EScherichia coli share a common subunit. (1982) (34)
- Intracellular pH regulation in bacterial cells. (1986) (33)
- Structural biology: The ins and outs of drug transport (2006) (33)
- Histidine‐419 plays a role in energy coupling in the vesicular monoamine transporter from rat (1994) (33)
- Biogenesis of chloroplast membranes. 3. Light-dependent induction of proton pump activity in whole cells and its correlation to cytochrome f photooxidation during greening of a Chlamydomonas reinhardti mutant (y-I). (1969) (32)
- Identification of molecular hinge points mediating alternating access in the vesicular monoamine transporter VMAT2 (2013) (32)
- Electrogenic transport of biogenic amines in chromaffin granule membrane vesicles (1980) (32)
- MAS solid-state NMR studies on the multidrug transporter EmrE. (2007) (31)
- Photoinactivation and identification of the biogenic amine transporter in chromaffin granules from bovine adrenal medulla. (1982) (30)
- A structural model of EmrE, a multi-drug transporter from Escherichia coli. (2004) (29)
- Lifetime and rotational relaxation time of dansylgalactoside bound to the lac carrier protein. (1975) (29)
- Undecided membrane proteins insert in random topologies. Up, down and sideways: it does not really matter. (2012) (28)
- Identification of Residues in the Translocation Pathway of EmrE, a Multidrug Antiporter from Escherichia coli* (1996) (28)
- Differentiation between binding and transport of dansylgalactosides in Escherichia coli. (1975) (27)
- Exploring the Role of a Unique Carboxyl Residue in EmrE by Mass Spectrometry* (2005) (26)
- Amiloride and harmaline are potent inhibitors of NhaB a Na+/H+ antiporter from Escherichia coli (1995) (26)
- Photoreactions of chloroplasts in a glycine medium. (1971) (26)
- Volume regulation in Mycoplasma gallisepticum: evidence that Na+ is extruded via a primary Na+ pump (1989) (24)
- Fluorescent galactosides as probes for the lac carrier protein. (1977) (23)
- Specificity determinants in small multidrug transporters. (2015) (23)
- Competition as a way of life for H(+)-coupled antiporters. (2014) (23)
- Directed Evolution Reveals Hidden Properties of VMAT, a Neurotransmitter Transporter* (2009) (22)
- Vesicular monoamine transporters heterologously expressed in the yeast Saccharomyces cerevisiae display high-affinity tetrabenazine binding. (2001) (21)
- Vesicular neurotransmitter transporters Pharmacology, biochemistry and molecular analysis (1997) (21)
- EmrE, a Small Escherichia coli Multidrug Transporter, Protects Saccharomyces cerevisiae from Toxins by Sequestration in the Vacuole (1999) (20)
- Glycosylation of a Vesicular Monoamine Transporter: A Mutation in a Conserved Proline Residue Affects the Activity, Glycosylation, and Localization of the Transporter (1998) (20)
- A single amino acid substitution (Glu134‐‐>Ala) in NhaR1 increases the inducibility by Na+ of the product of nhaA, a Na+/H+ antiporter gene in Escherichia coli. (1994) (20)
- Controversy Over EmrE Structure (2007) (20)
- Characterization of Bacterial Drug Antiporters Homologous to Mammalian Neurotransmitter Transporters (2005) (19)
- Molecular biology of Na+/H+ antiporters: molecular devices that couple the Na+ and H+ circulation in cells. (1994) (19)
- Energy-dependent binding of dansylgalactoside to the lac carrier protein: direct binding measurements. (1976) (19)
- Covalent modification of the amine transporter with N,N'-dicyclohexylcarbodiimide. (1991) (18)
- New Substrates on the Block: Clinically Relevant Resistances for EmrE and Homologues (2012) (18)
- Mechanism of β-galactoside transport in Escherichia coli membrane vesicles (1976) (17)
- Role of Na+ cycle in cell volume regulation of Mycoplasma gallisepticum (1989) (17)
- A Transporter Interactome Is Essential for the Acquisition of Antimicrobial Resistance to Antibiotics (2016) (17)
- 31P‐CP–MAS NMR studies on TPP+ bound to the ion‐coupled multidrug transport protein EmrE (2000) (17)
- The amine transporter from bovine chromaffin granules. Partial purification. (1985) (16)
- The use of flow dialysis for determinations of deltapH and active transport. (1979) (16)
- Identification of Conformationally Sensitive Residues Essential for Inhibition of Vesicular Monoamine Transport by the Noncompetitive Inhibitor Tetrabenazine* (2013) (15)
- Acidification of Cytoplasm in Escherichia coli Provides a Strategy to Cope with Stress and Facilitates Development of Antibiotic Resistance (2020) (15)
- Topology determination of untagged membrane proteins. (2013) (15)
- The Escherichia coli effluxome. (2018) (14)
- Modification of arginyl or histidyl groups affects the energy coupling of the amine transporter. (1992) (14)
- Molecular and biochemical studies of rat vesicular monoamine transporter. (1998) (12)
- Bacterial membrane potential analyzed by spectrofluorocytometry (1985) (12)
- Emulating proton-induced conformational changes in the vesicular monoamine transporter VMAT2 by mutagenesis (2016) (12)
- Reconstitution of LAC carrier function in cholate-extracted membranes from Escherichia coli. (1979) (11)
- The Amine Transporter from Bovine Chromaffin Granules a (1985) (11)
- Cloning, sequencing and expression of the nhaA and nhaR genes from Salmonella enteritidis. (1992) (11)
- Microenvironment of the binding site in the lac carrier protein. (1977) (10)
- Deletion of the major Escherichia coli multidrug transporter AcrB reveals transporter plasticity and redundancy in bacterial cells (2019) (10)
- Vesicular Neurotransmitter Transporters (2002) (9)
- MH1, a second-site revertant of an Escherichia coli mutant lacking Na+/H+ antiporters (delta nhaA delta nhaB), regains Na+ resistance and a capacity to excrete Na+ in a delta microH(+)-independent fashion. (1995) (9)
- Molecular analysis of the role of Na+/H+ antiporters in bacterial cell physiology. (1993) (8)
- How Does Escherichia coli Regulate Internal pH (1982) (8)
- Osmotic swelling allows fusion of sendai virions with membranes of desialyzed erythrocytes and chromaffin granules. (1987) (7)
- What Can a Living Fossil Tell Us About Evolution and Mechanism of Ion-Coupled Transporters: The Story of Small Multidrug Transporters (2014) (7)
- Expression of neurotransmitter transporters for structural and biochemical studies. (2010) (6)
- The Amine Transporter from Bovine Chromaffin Granules: Photolabeling and Partial Purification a (1987) (5)
- From Bacterial Antibiotic Resistance to Neurotransmitter Uptake (1994) (5)
- Control of sodium fluxes in Mycoplasma gallisepticum. (1987) (5)
- Functionally Important Carboxyls in a Bacterial Homologue of the Vesicular Monoamine Transporter (VMAT)* (2014) (5)
- A liposomal method for evaluation of inhibitors of H(+)-coupled multidrug transporters. (2016) (4)
- ACTIVE TRANSPORT IN ISOLATED BACTERIAL MEMBRANE VESICLES: BINDING OF β‐GALACTOSIDES TO THE LAC CARRIER PROTEIN (1975) (3)
- The Determination of ΔpH in Chloroplasts and Subchloroplast Particles (1972) (3)
- Purification of vesicular monoamine transporters: from classical techniques to histidine tags. (1998) (3)
- Cloning, sequencing and expression of the nhaA and nhaR genes from Salmonella entiritidis (2004) (3)
- Chapter 18 From multidrug resistance to vesicular neurotransmitter transport (1996) (3)
- Effects of ionophores and dicyclohexylcarbodiimide on Mycoplasma gallisepticum adherence to erythrocytes (1982) (3)
- From bacterial antibiotic resistance to neurotransmitter uptake. A common theme of cell survival. (1994) (2)
- Single Liposomes Used to Study the Activity of Individual Transporters (2014) (1)
- Electrogenic transport of biogenic amines in chromaffin granule membrane vesicle (1980) FEBS Letters 111, 83–86 (1980) (1)
- Active transport of biogenic amines in chromaffin granule membrane vesicles. (1980) (1)
- A common binding site for substrates and protons in EmrE, an ion-coupled multidrug transporter (2000) (1)
- MOLECULAR ASPECTS OF ACTIVE TRANSPORT (1976) (1)
- NhaRlincreases theinducibility byNa+oftheproduct ofnhaA,a Na+/H+antiporter gene inEscherichia coli (1994) (0)
- revealed by comparative modeling Structural conservation in the major facilitator superfamily as (2004) (0)
- A Common Tale of Substrate Recognition: from Antibiotic Resistance to Neurotransmitter Transport (2017) (0)
- Faculty Opinions recommendation of Role of protons in sugar binding to LacY. (2013) (0)
- HomologuesResistances for EmrE and New Substrates on the Block: Clinically (2012) (0)
- Drug Transport in Living Systems (2008) (0)
- Delta pH and membrane potential in bacterial chromatophores. (1974) (0)
- Faculty Opinions recommendation of Export of a single drug molecule in two transport cycles by a multidrug efflux pump. (2014) (0)
- Isolated Bacterial Cytoplasmic Membrane Vesicles: A Model System for the Study of Active Transport (1975) (0)
- NOTES AnAlkaline Shift Induces theHeatShockResponse in Escherichia coli (1987) (0)
- Identification of Escherichia coli Genes Essential for High-Level, Clinically Relevant, Resistance to Antibiotics (2021) (0)
- Transport and Storage of Biogenic Amines in Adrenal Chromaffin Granules (2019) (0)
- The role of glycosylation in the vesicular monoamine transporter (1997) (0)
- Escherichia coli , expulsion of sodium ions is driven by proton flux via at least two distinct Na + / H + antiporters , NhaA and NhaB (2001) (0)
- Acid Base ATP Synthesis in Chloroplasts (1977) (0)
- 7. Drug Transport in Living Systems (2012) (0)
- No Job Name (0)
- 7 TRANSPORT IN LIVING (2012) (0)
- Carboxyl Residues Required for Transport by a Vesicular Monoamine Transporter Homolog from Brevibacillus Brevis (BbMAT) (2015) (0)
- Noncompetitive Inhibitor Tetrabenazine Vesicular Monoamine Transport by the Residues Essential for Inhibition of Identification of Conformationally Sensitive Membrane Biology (2013) (0)
- monoamine transporter 2 Expression and function of the rat vesicular (2008) (0)
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