Shmuel Muallem

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Shmuel Muallem is affiliated with the following schools: University of California, Berkeley, Weizmann Institute of Science, Stanford University, Yonsei University, University of Texas Southwestern Medical Center

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Shmuel Muallem

Computer Science

#6707

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#7067

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Computational Linguistics

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#1228

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Machine Learning

#2266

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#2294

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Artificial Intelligence

#2532

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#2573

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computer-science Degrees

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Computer Science

Shmuel Muallem's Degrees

PhD Computer Science Stanford University
Masters Computer Science University of California, Berkeley
Bachelors Computer Science University of California, Berkeley

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Shmuel Muallem's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

STIM1 carboxyl-terminus activates native SOC, Icrac and TRPC1 channels (2006) (648)
SOAR and the polybasic STIM1 domains gate and regulate the Orai channels (2009) (636)
Functional interaction between InsP3 receptors and store-operated Htrp3 channels (1998) (617)
Dynamic Association of Proteasomal Machinery with the Centrosome (1999) (515)
STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels (2007) (500)
Homer Binds TRPC Family Channels and Is Required for Gating of TRPC1 by IP3 Receptors (2003) (486)
Gating of CFTR by the STAS domain of SLC26 transporters (2004) (439)
Actin filament disassembly is a sufficient final trigger for exocytosis in nonexcitable cells (1995) (436)
Aberrant CFTR-dependent HCO-3 transport in mutations associated with cystic fibrosis (2001) (376)
Molecular mechanism of pancreatic and salivary gland fluid and HCO3 secretion. (2012) (324)
NaBC1 is a ubiquitous electrogenic Na+ -coupled borate transporter essential for cellular boron homeostasis and cell growth and proliferation. (2004) (304)
STIM1 gates TRPC channels, but not Orai1, by electrostatic interaction. (2008) (302)
A molecular mechanism for aberrantCFTR‐dependent HCO3− transport in cystic fibrosis (2002) (284)
RGS Proteins Determine Signaling Specificity of Gq-coupled Receptors* (1999) (278)
Polarized Expression of Ca2+ Channels in Pancreatic and Salivary Gland Cells (1997) (275)
The N-terminal domain of the IP3 receptor gates store-operated hTrp3 channels. (1999) (263)
Evolution of calcium homeostasis: from birth of the first cell to an omnipresent signalling system. (2007) (258)
Parathyroid hormone-activated calcium channels in an osteoblast-like clonal osteosarcoma cell line. cAMP-dependent and cAMP-independent calcium channels. (1987) (258)
Hormone-evoked calcium release from intracellular stores is a quantal process. (1989) (251)
The N-terminal Domain of RGS4 Confers Receptor-selective Inhibition of G Protein Signaling* (1998) (247)
TRPC channels as STIM1-regulated store-operated channels. (2007) (227)
Cystic Fibrosis Transmembrane Conductance Regulator Regulates Luminal Cl−/HCO3 −Exchange in Mouse Submandibular and Pancreatic Ducts* (1999) (205)
TRP-ML1 Regulates Lysosomal pH and Acidic Lysosomal Lipid Hydrolytic Activity* (2006) (204)
Polarized Expression of Ca2+ Pumps in Pancreatic and Salivary Gland Cells (1997) (192)
The solute carrier 26 family of proteins in epithelial ion transport. (2008) (184)
Coupling Modes and Stoichiometry of Cl−/HCO3 − Exchange by slc26a3 and slc26a6 (2006) (174)
Transporter-mediated bile acid uptake causes Ca2+-dependent cell death in rat pancreatic acinar cells. (2002) (168)
Depletion of intracellular Ca2+ stores activates nitric-oxide synthase to generate cGMP and regulate Ca2+ influx. (1994) (162)
Native Store-operated Ca2+ Influx Requires the Channel Function of Orai1 and TRPC1* (2009) (158)
Gating of store-operated channels by conformational coupling to ryanodine receptors. (2000) (156)
Immuno and functional characterization of CFTR in submandibular and pancreatic acinar and duct cells. (1997) (155)
RANKL-mediated Reactive Oxygen Species Pathway That Induces Long Lasting Ca2+ Oscillations Essential for Osteoclastogenesis* (2010) (154)
Regulation of Cl−/ HCO3 −Exchange by Cystic Fibrosis Transmembrane Conductance Regulator Expressed in NIH 3T3 and HEK 293 Cells* (1999) (153)
Convergent regulation of the lysosomal two‐pore channel‐2 by Mg2+, NAADP, PI(3,5)P2 and multiple protein kinases (2014) (150)
Slc26a6 regulates CFTR activity in vivo to determine pancreatic duct HCO3− secretion: relevance to cystic fibrosis (2006) (150)
Spinophilin regulates Ca2+ signalling by binding the N-terminal domain of RGS2 and the third intracellular loop of G-protein-coupled receptors (2005) (149)
Mitochondria and calcium in health and disease. (2008) (148)
The Ca2+ Channel TRPML3 Regulates Membrane Trafficking and Autophagy (2009) (147)
An endoplasmic reticulum/plasma membrane junction: STIM1/Orai1/TRPCs (2010) (141)
TRP-ML1 Is a Lysosomal Monovalent Cation Channel That Undergoes Proteolytic Cleavage* (2005) (141)
Relationship of cAMP and calcium messenger systems in prostaglandin-stimulated UMR-106 cells. (1988) (140)
Molecular determinants of fast Ca2+-dependent inactivation and gating of the Orai channels (2009) (139)
Membrane localization of H+ and HCO3- transporters in the rat pancreatic duct (1994) (137)
Deletion of TRPC3 in mice reduces store-operated Ca2+ influx and the severity of acute pancreatitis. (2009) (137)
The Slc26a4 transporter functions as an electroneutral Cl−/I−/HCO3− exchanger: role of Slc26a4 and Slc26a6 in I− and HCO3− secretion and in regulation of CFTR in the parotid duct (2008) (136)
Homer proteins in Ca2+ signaling by excitable and non-excitable cells. (2007) (135)
Polarized but Differential Localization and Recruitment of STIM1, Orai1 and TRPC Channels in Secretory Cells (2011) (132)
IRBIT coordinates epithelial fluid and HCO3- secretion by stimulating the transporters pNBC1 and CFTR in the murine pancreatic duct. (2008) (132)
Diverse transport modes by the solute carrier 26 family of anion transporters (2009) (130)
Role of free cytosolic calcium in secretagogue-stimulated amylase release from dispersed acini from guinea pig pancreas. (1985) (129)
TRPC channels as STIM1-regulated SOCs (2009) (128)
SLC26A9 is a Cl− channel regulated by the WNK kinases (2007) (119)
Homer 1 Mediates Store- and Inositol 1,4,5-Trisphosphate Receptor-dependent Translocation and Retrieval of TRPC3 to the Plasma Membrane* (2006) (117)
Novel amiloride-sensitive sodium-dependent proton secretion in the mouse proximal convoluted tubule. (2000) (116)
Inositol trisphosphate modification of ion transport in rough endoplasmic reticulum. (1985) (114)
Translocation between PI(4,5)P2-poor and PI(4,5)P2-rich microdomains during store depletion determines STIM1 conformation and Orai1 gating (2014) (114)
Identification and Functional Analysis of Two Novel Mutations in the Multidrug Resistance Protein 2 Gene in Israeli Patients with Dubin-Johnson Syndrome* (2001) (113)
SLC26A7 Is a Cl– Channel Regulated by Intracellular pH* (2005) (112)
The STIM1 CTID domain determines access of SARAF to SOAR to regulate Orai1 channel function (2013) (111)
Gap junction communication modulates [Ca2+]i oscillations and enzyme secretion in pancreatic acini. (1993) (109)
Dynamic control of cystic fibrosis transmembrane conductance regulator Cl(-)/HCO3(-) selectivity by external Cl(-). (2004) (108)
AE4 is a DIDS-sensitive Cl(-)/HCO(-)(3) exchanger in the basolateral membrane of the renal CCD and the SMG duct. (2002) (108)
The agonist-sensitive calcium pool in the pancreatic acinar cell. Activation of plasma membrane Ca2+ influx mechanism. (1987) (107)
Genetic and pharmacologic inhibition of the Ca2+ influx channel TRPC3 protects secretory epithelia from Ca2+-dependent toxicity. (2011) (106)
Signalling specificity in GPCR-dependent Ca2+ signalling. (2003) (105)
Gain-of-function Mutation in TRPML3 Causes the Mouse Varitint-Waddler Phenotype* (2007) (105)
Corticosteroids correct aberrant CFTR localization in the duct and regenerate acinar cells in autoimmune pancreatitis. (2010) (101)
Orai1-Mediated Antimicrobial Secretion from Pancreatic Acini Shapes the Gut Microbiome and Regulates Gut Innate Immunity. (2017) (101)
The Cystic Fibrosis Transmembrane Conductance Regulator Interacts with and Regulates the Activity of the HCO 3 − Salvage Transporter Human Na+-HCO 3 − Cotransport Isoform 3* (2002) (101)
Molecular Determinants Mediating Gating of Transient Receptor Potential Canonical (TRPC) Channels by Stromal Interaction Molecule 1 (STIM1)* (2014) (98)
Lysosome signaling controls the migration of dendritic cells (2017) (94)
IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway. (2011) (93)
Membrane-specific Regulation of Cl− Channels by Purinergic Receptors in Rat Submandibular Gland Acinar and Duct Cells* (1997) (93)
A New Mode of Ca2+ Signaling by G Protein-Coupled Receptors Gating of IP3 Receptor Ca2+ Release Channels by Gβγ (2003) (92)
Transient Receptor Potential Mucolipin 1 (TRPML1) and Two-pore Channels Are Functionally Independent Organellar Ion Channels* (2011) (91)
Homer 2 tunes G protein–coupled receptors stimulus intensity by regulating RGS proteins and PLCβ GAP activities (2003) (91)
Protease-activated receptor 2 exerts local protection and mediates some systemic complications in acute pancreatitis. (2004) (91)
The Mammalian Sec6/8 Complex Interacts with Ca2+ Signaling Complexes and Regulates Their Activity (2000) (89)
RGS proteins provide biochemical control of agonist-evoked [Ca2+]i oscillations. (2001) (89)
Properties of the depolarization-activated calcium and barium entry in osteoblast-like cells. (1989) (89)
Hypoxia reprograms calcium signaling and regulates myoglobin expression. (2009) (88)
Properties of the Ca2+-activated K+ channel in one-step inside-out vesicles from human red cell membranes (1982) (87)
HCO 3 − Salvage Mechanisms in the Submandibular Gland Acinar and Duct Cells* (2001) (85)
Activation of the Na+/H+ and Cl-/HCO3- exchange by stimulation of acid secretion in the parietal cell. (1988) (82)
Irbit mediates synergy between ca(2+) and cAMP signaling pathways during epithelial transport in mice. (2013) (81)
STIM1-dependent and STIM1-independent Function of Transient Receptor Potential Canonical (TRPC) Channels Tunes Their Store-operated Mode* (2010) (81)
Multiple functional P2X and P2Y receptors in the luminal and basolateral membranes of pancreatic duct cells. (1999) (80)
A novel mode of TRPML3 regulation by extracytosolic pH absent in the varitint‐waddler phenotype (2008) (80)
The route of Ca2+ entry during reloading of the intracellular Ca2+ pool in pancreatic acini. (1990) (80)
Calcium transport pathways of pancreatic acinar cells. (1989) (79)
Reactive Oxygen Species-mediated TRPC6 Protein Activation in Vascular Myocytes, a Mechanism for Vasoconstrictor-regulated Vascular Tone* (2011) (78)
Ca(2+)-dependent kinase and phosphatase control inositol 1,4,5-trisphosphate-mediated Ca2+ release. Modification by agonist stimulation. (1993) (78)
Borate Transport and Cell Growth and Proliferation: Not Only in Plants (2005) (78)
cAMP and Ca²⁺ signaling in secretory epithelia: crosstalk and synergism. (2014) (76)
Electrolyte transport across the basolateral membrane of the parietal cells. (1985) (75)
Characterization of volume-sensitive, calcium-permeating pathways in the osteosarcoma cell line UMR-106-01. (1989) (75)
Plasticity and adaptation of Ca2+ signaling and Ca2+‐dependent exocytosis in SERCA2+/− mice (2001) (74)
Consequences of Functional Expression of the Plasma Membrane Ca Pump Isoform 1a (*) (1996) (74)
Membrane Potential Regulates Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Dependence of the pH- and Ca2+-sensitive Organellar Two-pore Channel TPC1* (2012) (74)
Cytosolic pH regulation in osteoblasts. Interaction of Na+ and H+ with the extracellular and intracellular faces of the Na+/H+ exchanger (1988) (73)
Multiple Effects of SERCA2b Mutations Associated with Darier's Disease* (2003) (73)
Simultaneous recording of cell volume changes and intracellular pH or Ca2+ concentration in single osteosarcoma cells UMR-106-01. (1992) (72)
Membrane‐limited expression and regulation of Na+‐H+ exchanger isoforms by P2 receptors in the rat submandibular gland duct (1998) (72)
Protein kinase C-activated calcium channel in the osteoblast-like clonal osteosarcoma cell line UMR-106. (1987) (72)
Acidic Ca(2+) stores come to the fore. (2011) (71)
Selective Gαi Subunits as Novel Direct Activators of Transient Receptor Potential Canonical (TRPC)4 and TRPC5 Channels* (2012) (71)
Spacial Compartmentalization of Ca2+ Signaling Complexes in Pancreatic Acini* (1996) (69)
Na(+)-dependent transporters mediate HCO(3)(-) salvage across the luminal membrane of the main pancreatic duct. (2000) (69)
Peptidyl-Prolyl Isomerase FKBP52 Controls Chemotropic Guidance of Neuronal Growth Cones via Regulation of TRPC1 Channel Opening (2009) (68)
Activation of the plasma membrane Ca2+ pump during agonist stimulation of pancreatic acini. (1992) (68)
Induction of Inducible Nitric-oxide Synthase by the Heterotrimeric G Protein G(*) (1996) (67)
Characterization and Localization of P2 Receptors in Rat Submandibular Gland Acinar and Duct Cells* (1997) (66)
Congenital Chloride-losing Diarrhea Causing Mutations in the STAS Domain Result in Misfolding and Mistrafficking of SLC26A3* (2008) (66)
Polarized Expression of G Protein-coupled Receptors and an All-or-None Discharge of Ca2+ Pools at Initiation Sites of [Ca2+] i Waves in Polarized Exocrine Cells* (2001) (65)
Alternate Coupling of Receptors to Gs and Gi in Pancreatic and Submandibular Gland Cells* (1999) (64)
ROS and intracellular ion channels. (2016) (64)
The closing and opening of TRPC channels by Homer1 and STIM1 (2012) (64)
Aberrant Localization of Intracellular Organelles, Ca2+ Signaling, and Exocytosis in Mist1 Null Mice* (2005) (63)
Determinants of coupled transport and uncoupled current by the electrogenic SLC26 transporters (2011) (63)
Regulatory interaction between calmodulin and ATP on the red cell Ca2+ pump. (1980) (63)
Regulation of free cytosolic Ca2+ in the peptic and parietal cells of the rabbit gastric gland. (1986) (62)
Calcium signaling complexes in microdomains of polarized secretory cells. (2006) (62)
Inositol 1-,4-,5-trisphosphate-dependent Ca2+ signaling by the recombinant human PTH/PTHrP receptor stably expressed in a human kidney cell line. (1996) (61)
ER stress disrupts Ca2+-signaling complexes and Ca2+ regulation in secretory and muscle cells from PERK-knockout mice (2006) (61)
Regulatory interaction between CFTR and the SLC26 transporters. (2006) (60)
Na+, K+, and H+/HCO3− Transport in Submandibular Salivary Ducts (1995) (60)
Mechanism and synergism in epithelial fluid and electrolyte secretion (2014) (60)
Intracellular pH-regulatory mechanisms in pancreatic acinar cells. I. Characterization of H+ and HCO3- transporters. (1990) (60)
Cell-specific Behavior of P2X7 Receptors in Mouse Parotid Acinar and Duct Cells* (2003) (59)
Spinophilin/neurabin reciprocally regulate signaling intensity by G protein‐coupled receptors (2007) (59)
Regulation of Ca2+-release-activated Ca2+ current (Icrac) by ryanodine receptors in inositol 1,4,5-trisphosphate-receptor-deficient DT40 cells. (2001) (58)
TRPML: transporters of metals in lysosomes essential for cell survival? (2011) (58)
Characterization, localization and axial distribution of Ca2+ signalling receptors in the rat submandibular salivary gland ducts. (1996) (57)
Changes in cytosolic free Ca2+ in isolated parietal cells. Differential effects of secretagogues. (1984) (57)
Regulatory Interaction between the Cystic Fibrosis Transmembrane Conductance Regulator and HCO 3 − Salvage Mechanisms in Model Systems and the Mouse Pancreatic Duct* (2001) (57)
Convergence of IRBIT, phosphatidylinositol (4,5) bisphosphate, and WNK/SPAK kinases in regulation of the Na+-HCO3− cotransporters family (2013) (57)
Lipids at membrane contact sites: cell signaling and ion transport (2017) (56)
Protein-protein interaction and functionTRPC channels (2005) (56)
Synchronized oscillation of Ca2+ entry and Ca2+ release in agonist-stimulated AR42J cells. (1991) (55)
Intracellular pH-regulatory mechanisms in pancreatic acinar cells. II. Regulation of H+ and HCO3- transporters by Ca2(+)-mobilizing agonists. (1990) (54)
A role for the Ca2+ channel TRPML1 in gastric acid secretion, based on analysis of knockout mice. (2011) (54)
nNOS and Ca2+ influx in rat pancreatic acinar and submandibular salivary gland cells. (1997) (52)
Manoalide, a natural sesterterpenoid that inhibits calcium channels. (1987) (52)
SLC26A6 and NaDC-1 transporters interact to regulate oxalate and citrate homeostasis. (2013) (50)
Modulation of osteoblast function by prostaglandins. (1989) (49)
CFTR: A New Horizon in the Pathomechanism and Treatment of Pancreatitis. (2016) (49)
Intracellular Cl− as a signaling ion that potently regulates Na+/HCO3− transporters (2015) (48)
G protein-dependent Ca2+ signaling complexes in polarized cells. (1999) (48)
Mining of Ebola virus entry inhibitors identifies approved drugs as two-pore channel pore blockers☆ (2018) (46)
Gβγ Transduces [Ca2+]i Oscillations and Gαq a Sustained Response during Stimulation of Pancreatic Acinar Cells with [Ca2+]i-mobilizing Agonists* (1996) (46)
Promiscuous Coupling of Receptors to Gq Class α Subunits and Effector Proteins in Pancreatic and Submandibular Gland Cells* (1998) (46)
The ER/PM microdomain, PI(4,5)P₂ and the regulation of STIM1-Orai1 channel function. (2015) (45)
When EGF is offside, magnesium is wasted. (2007) (45)
Regulation of the Inositol 1,4,5-Trisphosphate-activated Ca Channel by Activation of G Proteins (*) (1996) (44)
Role of Regulator of G Protein Signaling 2 (RGS2) in Ca2+ Oscillations and Adaptation of Ca2+ Signaling to Reduce Excitability of RGS2–/– Cells* (2004) (44)
Regulation of the Miniature Plasma Membrane Ca2+ Channel I min by Inositol 1,4,5-Trisphosphate Receptors* (1999) (44)
Spinophilin regulates Ca 2 + signalling by binding the N-terminal domain of RGS 2 and the third intracellular loop of G-protein-coupled receptors (2005) (43)
Anoctamin 8 tethers endoplasmic reticulum and plasma membrane for assembly of Ca2+ signaling complexes at the ER/PM compartment (2019) (43)
Aberrant Ca2+ handling in lysosomal storage disorders. (2010) (43)
Ca2+ Signaling in Microdomains (2007) (43)
Cytosolic pH regulation in osteoblasts. Regulation of anion exchange by intracellular pH and Ca2+ ions (1990) (42)
Feedback inhibition of Ca2+ release by Ca2+ is the underlying mechanism of agonist-evoked intracellular Ca2+ oscillations in pancreatic acinar cells. (1992) (41)
Ca2+ metabolism during cholinergic stimulation of acid secretion. (1985) (41)
Studies on the mechanism of regulation of the red-cell Ca2+ pump by calmodulin and ATP. (1981) (41)
TRPC channels: interacting proteins. (2007) (41)
Functional Mapping of Ca2+ Signaling Complexes in Plasma Membrane Microdomains of Polarized Cells* (2004) (40)
The TRPCs-STIM1-Orai interaction. (2014) (39)
Solute Carrier Family 26 Member a2 (Slc26a2) Protein Functions as an Electroneutral SO42−/OH−/Cl− Exchanger Regulated by Extracellular Cl−* (2011) (38)
Catalytic and regulatory ATP-binding sites of the red cell Ca2+ pump studied by irreversible modification with fluorescein isothiocyanate. (1983) (38)
The WNK/SPAK and IRBIT/PP1 pathways in epithelial fluid and electrolyte transport. (2012) (37)
Borate transport and cell growth and proliferation (2005) (37)
Physiology of Duct Cell Secretion (2009) (37)
The α2B‐adrenergic receptor is mutant in cortical myoclonus and epilepsy (2014) (36)
Serine-threonine kinase with-no-lysine 4 (WNK4) controls blood pressure via transient receptor potential canonical 3 (TRPC3) in the vasculature (2011) (36)
Classification of prostaglandin receptors based on coupling to signal transduction systems. (1989) (36)
Restoration of CFTR Activity in Ducts Rescues Acinar Cell Function and Reduces Inflammation in Pancreatic and Salivary Glands of Mice. (2017) (36)
Selective modification of the kinetic properties of Na+/H+ exchanger by cell shrinkage and swelling. (1988) (35)
Mitochondrial Ca2+ homeostasis in lysosomal storage diseases. (2008) (34)
Essential role of carbonic anhydrase XII in secretory gland fluid and HCO3− secretion revealed by disease causing human mutation (2015) (34)
The gatekeepers of mitochondrial calcium influx: MICU1 and MICU2 (2014) (34)
Agonist-sensitive calcium pool in the pancreatic acinar cell. II. Characterization of reloading. (1988) (34)
Regulation of the P2X7 Receptor Permeability to Large Molecules by Extracellular Cl– and Na+* (2005) (34)
Fatty acids, diacylglycerol, Ins(1,4,5)P 3 receptors and Ca2+ influx (1999) (34)
Inhibition of inositol 1,4,5-trisphosphate-mediated Ca2+ release by Ca2+ in cells from peripheral tissues. (1990) (33)
Fusion of lysosomes with secretory organelles leads to uncontrolled exocytosis in the lysosomal storage disease mucolipidosis type IV (2016) (33)
Correction of Ductal CFTR Activity Rescues Acinar Cell and Pancreatic and Salivary Gland Functions in Mouse Models of Autoimmune Disease (2017) (32)
Compartmentalization of Ca2+ signaling and Ca2+ pools in pancreatic acini. Implications for the quantal behavior of Ca2+ release. (1994) (32)
Agonist-sensitive and -insensitive intracellular Ca2+ pools. Separate Ca(2+)-releasing mechanisms revealed by manoalide and benzohydroquinone. (1991) (32)
SLC26A7 Can function as a chloride-loading mechanism in parietal cells (2007) (31)
Regulation of intracellular Ca2+ oscillation in AR42J cells. (1990) (31)
Agonist-mediated Ca2+ release in permeabilized UMR-106-01 cells. Transport properties and generation of inositol 1,4,5-trisphosphate. (1990) (31)
Cl(-)-dependent HCO3- transport by cystic fibrosis transmembrane conductance regulator. (2001) (30)
STIM-TRP Pathways and Microdomain Organization: Ca2+ Influx Channels: The Orai-STIM1-TRPC Complexes. (2017) (28)
Palmitoylation controls trafficking of the intracellular Ca2+ channel MCOLN3/TRPML3 to regulate autophagy (2018) (28)
Ca2+ influx at the ER/PM junctions. (2017) (28)
The N-terminal Domain of RGS 4 Confers Receptor-selective Inhibition of G Protein Signaling (1998) (27)
Role of calcium in cholecystokinin-stimulated phosphoinositide breakdown in exocrine pancreas. (1985) (27)
Two components of hormone-evoked calcium release from intracellular stores of pancreatic acinar cells. (1988) (27)
Role of Na+/Ca2+ exchange and the plasma membrane Ca2+ pump in hormone-mediated Ca2+ efflux from pancreatic acini (1988) (26)
IRBIT: It Is Everywhere (2011) (26)
Cl- as a bona fide signalling ion (2019) (26)
Modulation of agonist-activated calcium influx by extracellular pH in rat pancreatic acini. (1989) (26)
Differential Regulation of Ca2+ Release-activated Ca2+ Influx by Heterotrimeric G Proteins (*) (1995) (26)
Na+, K+, and Cl- transport in resting pancreatic acinar cells (1995) (26)
Convergent regulation of the lysosomal two-pore channel- 2b y Mg 2+ , NAADP, PI(3,5)P 2 and multiple (2014) (25)
A common mechanism for activation of the Na+/H+ exchanger by different types of stimuli (1989) (25)
Agonist-sensitive calcium pool in the pancreatic acinar cell. I. Permeability properties. (1988) (24)
Ca2+ Influx Channel Inhibitor SARAF Protects Mice From Acute Pancreatitis. (2019) (24)
High [Ca2+]i domains, secretory granules and exocytosis. (1997) (24)
Regulation of Ca 2 +-release-activated Ca 2 + current ( I crac ) by ryanodine receptors in inositol 1 , 4 , 5-trisphosphate-receptor-deficient DT 40 cells (24)
The intracellular Ca2+ channels of membrane traffic (2012) (24)
Polarized Expression of Ca 2 1 Pumps in Pancreatic and Salivary Gland Cells (1997) (23)
Transient Receptor Potential Canonical Type 3 Channels Control the Vascular Contractility of Mouse Mesenteric Arteries (2014) (23)
Lysosomal Ca2+ Signaling is Essential for Osteoclastogenesis and Bone Remodeling (2017) (22)
Homer2 Protein Regulates Plasma Membrane Ca2+-ATPase-mediated Ca2+ Signaling in Mouse Parotid Gland Acinar Cells* (2014) (22)
Properties of the TRPML3 Channel Pore and Its Stable Expansion by the Varitint-Waddler-causing Mutation* (2010) (22)
Regulation of [Na+]i in Resting and Stimulated Submandibular Salivary Ducts (*) (1995) (22)
Pancreatitis: the neglected duct (2008) (22)
TRPpathies (2007) (21)
Skeletal muscle dressed in SOCs (2008) (21)
Regulation of agonist-evoked [Ca2+]i oscillation by intracellular Ca2+ and Ba2+ in AR42J cells. (1992) (21)
Ca(2+) signalling and gene regulation. (2011) (20)
Activation of the endoplasmic reticulum Ca2+ pump of pancreatic acini by Ca2+ mobilizing hormones. (1987) (20)
Multiple Roles of the SO42−/Cl−/OH− Exchanger Protein Slc26a2 in Chondrocyte Functions* (2013) (20)
Regulatory interaction of ATP Na+ and Cl- in the turnover cycle of the NaK2Cl cotransporter (1993) (19)
Systemic Succinate Homeostasis and Local Succinate Signaling Affect Blood Pressure and Modify Risks for Calcium Oxalate Lithogenesis. (2019) (19)
Exosomal release through TRPML1-mediated lysosomal exocytosis is required for adipogenesis. (2019) (19)
Modulation of Na+-H+ exchange activity by intracellular Na+, H+, and Li+ in IMCD cells. (1988) (19)
Aquaporin 1 water channel is overexpressed in the plasma membranes of pancreatic ducts in patients with autoimmune pancreatitis. (2009) (19)
Regulation of the Ca2+-pump by calmodulin in intact cells. (1982) (18)
Unlocking SOAR releases STIM (2011) (18)
Subpopulation of Store-operated Ca2+ Channels Regulate Ca2+-induced Ca2+ Release in Non-excitable Cells* (2004) (17)
Orai1 and STIM1 in ER/PM junctions: roles in pancreatic cell function and dysfunction. (2016) (17)
Regulation of Na-K-2Cl cotransport in osteoblasts. (1991) (17)
Prostaglandins enhance parathyroid hormone-evoked increase in free cytosolic calcium concentration in osteoblast-like cells. (1991) (16)
The TRPCs, Orais and STIMs in ER/PM Junctions. (2016) (16)
Detection of a Na+-H+ antiporter in cultured rat renal papillary collecting duct cells. (1987) (15)
Regulatory volume decrease in the presence of HCO3- by single osteosarcoma cells UMR-106-01. (1992) (15)
Regulation of cell volume by the osteosarcoma cell line UMR-106-01. (1991) (14)
Modulation of Cl− signaling and ion transport by recruitment of kinases and phosphatases mediated by the regulatory protein IRBIT (2018) (14)
Coordination of pancreatic HCO3- secretion by protein-protein interaction between membrane transporters. (2001) (14)
Ca(2+) signaling mechanisms of cell survival and cell death: an introduction. (2011) (14)
Transport and interaction of nitrogen oxides and NO2 with CO2-HCO3- transporters in pancreatic acini. (1994) (14)
Decoding Ca2+ signals (2005) (13)
What the mitochondria see. (2010) (13)
Lipids in Ca2+ signalling--an introduction. (2009) (12)
Agonist-specific regulation of [Na+]i in pancreatic acinar cells (1995) (11)
Dissociation between parathyroid hormone‐stimulated cAMP and calcium increase in UMR‐106‐01 cells (1992) (11)
Ca2+ signaling in polarized exocrine cells. (2002) (11)
Cloning, expression and functional characterization of the putative regeneration and tolerance factor (RTF/TJ6) as a functional vacuolar ATPase proton pump regulatory subunit with a conserved sequence of immunoreceptor tyrosine-based activation motif. (2005) (10)
Characteristics of intracellular calcium changes required for augmentation of phorbol ester-stimulated pancreatic enzyme secretion. (1989) (10)
Relationship between hormonal, GTP and Ins(1,4,5)P3-stimulated Ca2+ uptake and release in pancreatic acinar cells. (1989) (9)
Calcium mobilizing hormones activate the plasma membrane Ca2+ pump of pancreatic acinar cells (1988) (9)
A simple, rapid and efficient procedure for purification of calmodulin from human red cells (1979) (9)
Antagonists inactivate the inositol 1,4,5-trisphosphate (Ins-1,4,5-P3)-dependent Ca2+ channel independent of Ins-1,4,5-P3 metabolism. (1994) (9)
Markers of squamous cell carcinoma in sarco/endoplasmic reticulum Ca2+ ATPase 2 heterozygote mice keratinocytes. (2010) (9)
Homer2 and Homer3 modulate RANKL-induced NFATc1 signaling in osteoclastogenesis and bone metabolism. (2019) (9)
The nature of the Ca2+-pump defect in the red blood cells of patients with cystic fibrosis. (1985) (9)
Functional characterisation of the CFTR mutations M348V and A1087P from patients with pancreatitis suggests functional interaction between CFTR monomers (2009) (9)
Sites and mechanisms of Ca2+ movement in non-excitable cells. (1989) (9)
Analyses of RGS protein control of agonist-evoked Ca2+ signaling. (2004) (9)
Opening the TRPML gates. (2010) (8)
TRPC3 channel gating by lipids requires localization at the ER/PM junctions defined by STIM1 (2022) (8)
Gbetagamma transduces [Ca2+]i oscillations and Galphaq a sustained response during stimulation of pancreatic acinar cells with [Ca2+]i-mobilizing agonists. (1996) (8)
Multiple functional P2X and P2Y receptors in the luminal and basolateral membranes of pancreatic duct cells. (1999) (8)
The ins and outs of Ca2+ in exocrine cells. (1992) (7)
Passive and active transport in the parietal cell. (1988) (7)
The Ca-activated K channel of human red cells: all or none behaviour of the Ca2+-gating mechanism. (1983) (7)
Regulation of intracellular calcium in epithelial cells. (1990) (7)
Ca2+ Signaling in Exocrine Cells. (2020) (6)
ROS and Ca(2+)-Partners in sickness and in health. (2016) (6)
CRAC channels in secretory epithelial cell function and disease. (2019) (6)
Calcium Signaling: Pyruvate and CRAC Meet at the Crossroads (2007) (5)
TRPML1 as lysosomal fusion guard (2016) (5)
How does NAADP release lysosomal Ca2+? (2014) (5)
Mediates Store-and Inositol 1 , 4 , 5-Trisphosphate Receptor-dependent Translocation and Retrieval of TRPC 3 to the Plasma Membrane * (2006) (4)
Molecular Mechanism of Pancreatic Bicarbonate Secretion (2017) (4)
Oncogenes calling on a lysosomal Ca2+ channel (2019) (4)
ROS in Ca(2+) signaling and disease-part 2. (2016) (3)
Dynamic Control of Cystic Fibrosis Transmembrane Conductance Regulator \batchmode \documentclass[fleqn,10pt,legalpaper]{article} \usepackage{amssymb} \usepackage{amsfonts} \usepackage{amsmath} \pagestyle{empty} \begin{document} \(\mathrm{Cl}^{-}{/}\mathrm{HCO}_{3}^{-}\) \end{document} Selectivity by (2004) (3)
Regulation of the P 2 X 7 Receptor Permeability to Large Molecules by Extracellular (2005) (2)
STIM-TRP pathways the STIM1/Orai/TRPC channels multiple Ca2+ influx complexes (2012) (2)
Agonist-mediated Ca2' Release in Permeabilized UMR- 106-O 1 Cells (1990) (2)
Inositol phosphate levels during Ca2+ reloading of internal Ca2+ stores in the exocrine pancreas. (1988) (2)
Basal and stimulated cytosolic platelet calcium in essential hypertension. (1990) (2)
Orai 1 and STIM 1 in ER / PM junctions : roles in pancreatic cell function and dysfunction (2016) (2)
The CAR that drives Ca2+ to Orai1 (2016) (2)
Osteoclastogenesis Oscillations Essential for 2 + Pathway That Induces Long Lasting Ca RANKL-mediated Reactive Oxygen Species Cell (2010) (2)
No Zoom Required: Meeting at the β-Intercalated Cells. (2020) (2)
Regulation of the Miniature Plasma Membrane Ca 21 Channel I min by Inositol (1999) (2)
Egg activation and the egg-to-embryo transition. Preface. (2013) (1)
Evidence for activation of the ER-Ca2+ pump in intact and permeabilized cells by Ca2+ mobilizing hormones. (1988) (1)
Pharmacological Rescue of Ductal CFTR Rescue Pancreatic and Salivary glands Acinar Cells and Tissue Function in Mouse Models of Autoimmune diseases (2017) (1)
Specificity of Ca2+ Signaling in Polarized Cells (2000) (1)
Methods to Study TRPC Channel Regulation by Interacting Proteins (2011) (1)
Properties and Function of the Solute Carrier 26 Family of Anion Transporters (2016) (1)
The intracellular Ca2+ channel TRPML3 is a PI3P effector that regulates autophagosome biogenesis (2022) (1)
Opening the Orai1 gates (2017) (1)
Single cell recording of quin 2 fluorescence. (1984) (1)
Functional characterization of L1156F CFTR: a newly identified mutation in Japanese patients with chronic pancreatitis (2006) (1)
5 – Cellular Calcium and Phospholipid Metabolism Mediate Pancreatic Enzyme Secretion (1990) (1)
A novel Na+-dependent transporter and NHE3 mediate H+ efflux in the luminal membrane of the pancreatic duct: regulation by cAMP. (2000) (1)
Translocation between PI(4,5)P2-Poor and PI(4,5)P2-Rich Microdomains During Store Depletion Determines STIM1 Conformation and Gating of Orai1 (2015) (1)
The art of physiology in the hands of the master: the calcium community celebrates the 70th birthday of Ole Holger Petersen. (2013) (1)
Differential Regulation of Ca 2 (cid:49) Release-activated Ca 2 (cid:49) Influx by Heterotrimeric G Proteins* (1995) (1)
Signaling Complexes and Regulates their Activity (2000) (1)
Regulation of NBCe1-B by IRBIT, PIP2 and the WNK/SPAK Kinases (2013) (0)
Homer2 interacts with plasma membrane Ca2+ ATPase and regulates its activity in mouse parotid gland acinar cells (2009) (0)
Anoctamin8 Tethers the Endoplasmic Reticulum and Plasma Membranes to Assemble Ca 2+ Signaling Complexes at ER/PM Junctions (2020) (0)
The sun, cholesterol and Orai1 conspire in melanoma (2022) (0)
The n terminal domain of RGS4 confers regulatory specificity in g protein-receptor signaling (1998) (0)
in skeletal muscle i ) 2+ increases (Ca Paraxanthine, a caffeine metabolite, dose dependently (2015) (0)
CA2+ SIGNALING IN POLARIZED EPITHELIAL CELLS. (2000) (0)
Dynamic Properties of the TRPML3 Pore and their Modification by the Varitint-Waddler Phenotype (2009) (0)
Characterization of CFTR in salivary glands and pancreatic acinar and duct cells (1997) (0)
Receptor-specific Ca2+ signaling in polarized cells. (2000) (0)
Dynamic Control of Cystic Fibrosis Transmembrane Conductance Regulator Cl (cid:1) /HCO 3 (cid:1) Selectivity by External Cl (cid:1) * (2004) (0)
Physiological Implications of Transepithelial Carboxylic Acid Absorption and Regulation by Slc26a6 (2015) (0)
IRBIT Expands Signaling Repertoire at the ER/PM Junctions (2019) (0)
Expanding signaling repertoire of anoctamin 1 by localization at membrane contact sites (2022) (0)
Decision letter: Agonist-specific voltage-dependent gating of lysosomal two-pore Na+ channels (2019) (0)
Solute Carrier family 26 member a 2 ( Slc 26 a 2 ) functions as an electroneutral SO 4 = / OH-/ Cl-exchanger regulated by extracellular (2011) (0)
IRBIT regulates the WNK/SPAK pathway (2010) (0)
Regulation of Cl−in signaling and ion transport by IRBIT‐mediated recruitment of multiple kinase and phosphatase pathways (2019) (0)
Molecular Requirements for the Action of 2-APB on STIM1-Orai1 Coupling (2013) (0)
CFTR does it again: control of insulin secretion (2014) (0)
Aberrant CFTR-dependent transport inmutations associated with cystic fibrosis (2014) (0)
Mechanism and synergism in epithelial fluid and electrolyte secretion (2013) (0)
Lipid directive epithelial secretion by ER-PM tethers (2022) (0)
The STIM1 CTID Domain Regulates Orai1 Channel Function by Modulating SARAF Interaction (2013) (0)
The forefront of technology of science: Methods for monitoring cell function. (2017) (0)
An Oxalate/Citrate Homeostatic Pathway: The Oxalate Slc26a6 and Citrate NaDC-1 Transporters Interplay (2013) (0)
An Enormous Ventral (Epigastric) Hernia as a Cause of Acute Pancreatitis: Pfeffer's Closed Duodenal Loop Model in the Animal, First Seen in a Human (2003) (0)
Preface. Endolysosomal calcium signalling. (2023) (0)
The lipid transporter proteins ORP5 and ORP8 in Ca2+signaling (2022) (0)
Polarized but Differential Localization and Recruitment of STIM1, Orai1 and TRPC Channels in Secretory Cells (2011) (0)
Molecular Determinants of TRPC Channels Gating by STIM1 (2013) (0)
CFTR, SLC26 transporters and pancreatic HCO 3 - secretion (2006) (0)
Mutual regulatory interactions between CFTR and SLC26 anion exchanger. (2004) (0)
Intracellular C1 as a Signaling Molecule that Potently Regulates Na and HCO3 Transporters (2015) (0)
CFTR is not a gluten lover either (2019) (0)
IRBIT expands signaling repertoire: Regulation of the Ca2+‐activated Cl− channel Bestrophin 2 by synergy between Ca2+ and cAMP at membrane contact sites (2018) (0)
CFTR does it again: control of insulin secretion (2014) (0)
Similarities and Differences in Gating of the Two-Pore Channels TPC1 and TPC2 (2015) (0)
Pancreatitis from bile reflux-again? Authors' reply (2003) (0)
to intermittent hypoxia: the known and the unknown Invited Review: Adaptive responses of skeletal muscle (2015) (0)
Fusion of Lysosomes with Secretory Vesicle Leads to Excessive Uncontrolled Exocytosis in Mucolipidosis Type IV (2015) (0)
BASIC AND TRANSLATIONAL—PANCREAS Irbit Mediates Synergy Between Ca 2D and cAMP Signaling Pathways During Epithelial Transport in Mice (2013) (0)
TRPC, Orai1 and STIM1 in physiological and pathological Ca2+ influx (2013) (0)
Hydrophobic interactions within the C terminus pole helices tunnel regulate calcium-dependent inactivation of TRPC3 in a calmodulin-dependent manner. (2022) (0)
Reactive Oxygen Species (ROS) mediate agonist‐induced TRPC6 activation in vascular smooth muscle cells (VSMCS) (2011) (0)
THE STIM1 REGULATORS SARAF IN CA2+ SIGNALING IN VIVO (2016) (0)
Inhibition of Ca2+ Influx by SARAF and Pancreatitis (2019) (0)

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