Shun Shimohama
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Computer Science
Shun Shimohama's Degrees
- PhD Computer Science University of Tokyo
- Masters Computer Science University of Tokyo
- Bachelors Computer Science University of Tokyo
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(Suggest an Edit or Addition)Shun Shimohama's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Oxidative Damage Is the Earliest Event in Alzheimer Disease (2001) (1811)
- Activation and Involvement of p38 Mitogen-activated Protein Kinase in Glutamate-induced Apoptosis in Rat Cerebellar Granule Cells* (1997) (445)
- α7 Nicotinic Receptor Transduces Signals to Phosphatidylinositol 3-Kinase to Block A β-Amyloid-induced Neurotoxicity* (2001) (385)
- Safety and efficacy of eculizumab in anti-acetylcholine receptor antibody-positive refractory generalised myasthenia gravis (REGAIN): a phase 3, randomised, double-blind, placebo-controlled, multicentre study (2017) (341)
- Nicotinic receptor stimulation protects neurons against β‐amyloid toxicity (1997) (311)
- Microglial activation and amyloid‐β clearance induced by exogenous heat‐shock proteins (2002) (279)
- Activation of NADPH oxidase in Alzheimer's disease brains. (2000) (277)
- Ribosomal RNA in Alzheimer Disease Is Oxidized by Bound Redox-active Iron* (2005) (270)
- Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation (2008) (262)
- Changes in Nicotinic and Muscarinic Cholinergic Receptors in Alzheimer‐Type Dementia (1986) (259)
- Grafting fibroblasts genetically modified to produce L-dopa in a rat model of Parkinson disease. (1989) (251)
- Phosphatidylinositol 3‐kinase mediates neuroprotection by estrogen in cultured cortical neurons (2000) (249)
- Estradiol protects mesencephalic dopaminergic neurons from oxidative stress‐induced neuronal death (1998) (246)
- Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in Alzheimer's disease (1998) (246)
- The 4F2hc/LAT1 complex transports l-DOPA across the blood–brain barrier (2000) (245)
- Apoptosis in Alzheimer's disease—an update (2000) (244)
- Nicotine-induced protection of cultured cortical neurons againstN-methyl-D-aspartate receptor-mediated glutamate cytotoxicity (1994) (237)
- Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4‐phenylbutyrate, a chemical chaperone (2007) (223)
- Increased expression of cyclooxygenases and peroxisome proliferator-activated receptor-gamma in Alzheimer's disease brains. (1999) (217)
- Nicotine protects cultured cortical neurons against glutamate-induced cytotoxicity via α7-neuronal receptors and neuronal CNS receptors (1997) (203)
- Trophic effect of beta-amyloid precursor protein on cerebral cortical neurons in culture. (1991) (201)
- Stimulation of α4β2 nicotinic acetylcholine receptors inhibits β-amyloid toxicity (1998) (193)
- alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity. (2001) (188)
- Protective effects of 1α,25-(OH)2D3 against the neurotoxicity of glutamate and reactive oxygen species in mesencephalic culture (2001) (184)
- Disease model: Parkinson's disease. (2003) (181)
- Dopamine D2‐type agonists protect mesencephalic neurons from glutamate neurotoxicity: Mechanisms of neuroprotective treatment against oxidative stress (1998) (181)
- Changes of p53 in the brains of patients with Alzheimer's disease. (1997) (175)
- PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson’s disease rat model (2006) (174)
- Differential involvement of protein kinase C isozymes in Alzheimer's disease (1990) (167)
- Mechanisms of antiapoptotic effects of estrogens in nigral dopaminergic neurons (2000) (164)
- Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans (2002) (163)
- Galantamine-induced Amyloid-β Clearance Mediated via Stimulation of Microglial Nicotinic Acetylcholine Receptors* (2010) (150)
- Activation of MKK6, an upstream activator of p38, in Alzheimer's disease (2001) (145)
- Effects of brain-derived neurotrophic factor on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in monkeys. (1995) (143)
- Microglial activation and amyloid-beta clearance induced by exogenous heat-shock proteins. (2002) (138)
- Protective effects of 1 alpha,25-(OH)(2)D(3) against the neurotoxicity of glutamate and reactive oxygen species in mesencephalic culture. (2001) (137)
- Nicotinic α7 receptors protect against glutamate neurotoxicity and neuronal ischemic damage (1998) (130)
- Proteasome Inhibition Induces Glutathione Synthesis and Protects Cells from Oxidative Stress (2007) (129)
- Reconstruction of dopaminergic neural network and locomotion function in planarian regenerates (2007) (129)
- Alzheimer's disease and acetylcholine receptors. (2004) (128)
- Cl−-ATPase and Na+/K+-ATPase activities in Alzheimer's disease brains (1998) (127)
- High Molecular Weight Neurofilament Proteins Are Physiological Substrates of Adduction by the Lipid Peroxidation Product Hydroxynonenal* (2002) (127)
- Characterization of sequential N-cadherin cleavage by ADAM10 and PS1 (2006) (126)
- Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations. (2005) (124)
- Nicotinic receptor stimulation protects neurons against beta-amyloid toxicity. (1997) (123)
- Exercise Is More Effective than Diet Control in Preventing High Fat Diet-induced β-Amyloid Deposition and Memory Deficit in Amyloid Precursor Protein Transgenic Mice*♦ (2012) (121)
- Galantamine modulates nicotinic receptor and blocks Abeta-enhanced glutamate toxicity. (2004) (118)
- Nicotine‐induced Protection Against Glutamate Cytotoxicity (1996) (118)
- Proteasome Mediates Dopaminergic Neuronal Degeneration, and Its Inhibition Causes α-Synuclein Inclusions* (2004) (115)
- N‐methyl‐D‐aspartate receptor‐mediated mitochondrial Ca2+ overload in acute excitotoxic motor neuron death: A mechanism distinct from chronic neurotoxicity after Ca2+ influx (2001) (113)
- Neuroprotective effects of estradiol in mesencephalic dopaminergic neurons (2000) (113)
- Nongenomic antiapoptotic signal transduction by estrogen in cultured cortical neurons (2001) (111)
- Grafting genetically modified cells into the rat brain: characteristics of E. coli beta-galactosidase as a reporter gene. (1989) (109)
- Neuroprotection by donepezil against glutamate excitotoxicity involves stimulation of α7 nicotinic receptors and internalization of NMDA receptors (2010) (108)
- Estradiol protects dopaminergic neurons in a MPP+Parkinson’s disease model (2002) (107)
- Apolipoprotein E polymorphism in Japanese patients with Alzheimer's disease or vascular dementia. (1994) (107)
- Dopamine Receptors and Parkinson's Disease (2011) (106)
- Oxidative stress causes abnormal accumulation of familial amyotrophic lateral sclerosis-related mutant SOD1 in transgenic Caenorhabditis elegans. (2001) (106)
- Stimulating nicotinic receptors trigger multiple pathways attenuating cytotoxicity in models of Alzheimer's and Parkinson's diseases. (2011) (105)
- Changes in caspase expression in Alzheimer's disease: comparison with development and aging. (1999) (105)
- Hydrogen peroxide–induced apoptosis mediated by p53 protein in glial cells (1999) (102)
- Nicotinic receptor-mediated neuroprotection in neurodegenerative disease models. (2009) (102)
- Proteomic Profiling and Neurodegeneration in Alzheimer's Disease (2002) (100)
- Alteration of transcription factors NF-κB and STAT1 in Alzheimer's disease brains (1997) (100)
- Nicotinic receptor stimulation protects nigral dopaminergic neurons in rotenone‐induced Parkinson's disease models (2009) (100)
- Environmental enrichment ameliorated high-fat diet-induced Aβ deposition and memory deficit in APP transgenic mice (2012) (98)
- Nicotinic receptor–mediated protection against β-amyloid neurotoxicity (2001) (97)
- Neuroprotective Mechanism of Glial Cell Line‐Derived Neurotrophic Factor in Mesencephalic Neurons (2000) (94)
- Microglial transplantation increases amyloid‐β clearance in Alzheimer model rats (2007) (92)
- p‐quinone mediates 6‐hydroxydopamine‐induced dopaminergic neuronal death and ferrous iron accelerates the conversion of p‐quinone into melanin extracellularly (2005) (91)
- Protective effect of dopamine D2 agonists in cortical neurons via the phosphatidylinositol 3 kinase cascade (2002) (91)
- Mechanism of selective motor neuronal death after exposure of spinal cord to glutamate: Involvement of glutamate‐induced nitric oxide in motor neuron toxicity and nonmotor neuron protection (1998) (91)
- m-Calpain (calcium-activated neutral proteinase) in Alzheimer's disease brains (1998) (88)
- Diagnostic accuracy of cardiac metaiodobenzylguanidine scintigraphy in Parkinson disease (2009) (87)
- BDNF prevents NO mediated glutamate cytotoxicity in cultured cortical neurons (1997) (87)
- Biochemical Characterization of the Nicotinic Cholinergic Receptors in Human Brain: Binding of (—)‐[3H]Nicotine (1985) (87)
- Differential involvement of synaptic vesicle and presynaptic plasma membrane proteins in Alzheimer's disease. (1997) (86)
- GSK3β Activity Modifies the Localization and Function of Presenilin 1* (2007) (86)
- Ca2+‐Dependent and Ca2+‐Independent Protein Kinase C Changes in the Brains of Patients with Alzheimer's Disease (1996) (85)
- Toxin-Induced and Genetic Animal Models of Parkinson's Disease (2010) (84)
- p75-mediated neuroprotection by NGF against glutamate cytotoxicity in cortical cultures (2000) (82)
- Intraneuronal amyloid β accumulation and oxidative damage to nucleic acids in Alzheimer disease (2010) (81)
- Stimulation of alpha4beta2 nicotinic acetylcholine receptors inhibits beta-amyloid toxicity. (1998) (78)
- Mesenchymal stem cells transmigrate across brain microvascular endothelial cell monolayers through transiently formed inter-endothelial gaps (2011) (78)
- Purification of a novel endothelin‐converting enzyme specific for big endothelin‐3 (1998) (77)
- Role of high mobility group protein-1 (HMG1) in amyloid-β homeostasis (2003) (75)
- N-methyl-D-aspartate receptor-mediated mitochondrial Ca(2+) overload in acute excitotoxic motor neuron death: a mechanism distinct from chronic neurotoxicity after Ca(2+) influx. (2001) (74)
- Protection of cultured spinal motor neurons by estradiol (2000) (73)
- Comparative biology and pathology of oxidative stress in Alzheimer and other neurodegenerative diseases: beyond damage and response. (2002) (71)
- Requirement for Mitogen-activated Protein Kinase in Cerebellar Long Term Depression* (1999) (69)
- Aberrant accumulation of phospholipase C-delta in Alzheimer brains. (1991) (68)
- Phosphodiesterase inhibitors are neuroprotective to cultured spinal motor neurons (2003) (68)
- Protective effect of nerve growth factor against glutamate-induced neurotoxicity in cultured cortical neurons (1993) (66)
- High mobility group box protein‐1 inhibits microglial Aβ clearance and enhances Aβ neurotoxicity (2004) (64)
- Differential expression of rat brain bcl-2 family proteins in development and aging. (1998) (63)
- Changes in benzodiazepine receptors in alzheimer‐type dementia (1988) (63)
- Changes in β‐Adrenergic Receptor Subtypes in Alzheimer‐Type Dementia (1987) (61)
- Coexistence of expanded CAG repeats in the MJD1a and DRPLA genes (2000) (61)
- Differential expression of rat brain synaptic proteins in development and aging. (1998) (60)
- Brain-derived neurotrophic factor pretreatment exerts a partially protective effect against glutamate-induced neurotoxicity in cultured rat cortical neurons (1993) (60)
- N-cadherin Regulates p38 MAPK Signaling via Association with JNK-associated Leucine Zipper Protein (2010) (60)
- Biochemical Characterization of α‐Adrenergic Receptors in Human Brain and Changes in Alzheimer‐Type Dementia (1986) (59)
- Recovery of focal brain ischemia-induced behavioral dysfunction by intracerebroventricular injection of microglia. (2005) (58)
- Effects of mitochondrial dysfunction on glutamate receptor-mediated neurotoxicity in cultured rat spinal motor neurons (2004) (58)
- Nicotine-induced protection against glutamate cytotoxicity. Nicotinic cholinergic receptor-mediated inhibition of nitric oxide formation. (1996) (56)
- Nicotinic alpha 7 receptors protect against glutamate neurotoxicity and neuronal ischemic damage. (1998) (56)
- Nicotinic receptor-mediated protection against beta-amyloid neurotoxicity. (2001) (56)
- Heat‐shock protein 105 interacts with and suppresses aggregation of mutant Cu/Zn superoxide dismutase: clues to a possible strategy for treating ALS (2007) (55)
- Differential expression of rat brain caspase family proteins during development and aging. (2001) (54)
- Possible involvement of both mitochondria- and endoplasmic reticulum-dependent caspase pathways in rotenone-induced apoptosis in human neuroblastoma SH-SY5Y cells (2002) (54)
- Different mechanisms of glutamate‐induced neuronal death between dopaminergic and non‐dopaminergic neurons in rat mesencephalic culture (1996) (54)
- CI-ATPase and Na+/K(+)-ATPase activities in Alzheimer's disease brains. (1998) (53)
- The parkinsonian models: invertebrates to mammals. (2000) (53)
- Microglial transplantation increases amyloid-beta clearance in Alzheimer model rats. (2007) (52)
- Methylphenylpyridium ion (MPP+) enhances glutamate‐induced cytotoxicity against dopaminergic neurons in cultured rat mesencephalon (1996) (51)
- Apoptotic promoters and inhibitors in Alzheimer's disease: Who wins out? (2003) (51)
- Depletion of Intracellular Glutathione Increases Susceptibility to Nitric Oxide in Mesencephalic Dopaminergic Neurons (1999) (51)
- Possible involvement of group I mGluRs in neuroprotective effect of theanine. (2004) (51)
- Idiopathic normal pressure hydrocephalus has a different cerebrospinal fluid biomarker profile from Alzheimer's disease. (2015) (50)
- Bip/GRP78-induced production of cytokines and uptake of amyloid-beta(1-42) peptide in microglia. (2001) (50)
- Dopamine is involved in selectivity of dopaminergic neuronal death by rotenone (2003) (50)
- Microglial Amyloid-β1-40 Phagocytosis Dysfunction Is Caused by High-Mobility Group Box Protein-1: Implications for the Pathological Progression of Alzheimer's Disease (2012) (49)
- Evaluation of oxidative stress in the brain of a transgenic mouse model of Alzheimer disease by in vivo electron paramagnetic resonance imaging. (2015) (49)
- Neuroprotective properties of Bcl‐w in Alzheimer disease (2004) (49)
- Isolation of a diterpenoid substance with potent neuroprotective activity from fetal calf serum (2002) (49)
- Relationship between dysphagia and depressive states in patients with Parkinson's disease. (2011) (49)
- Stimulation of nicotinic acetylcholine receptors protects motor neurons. (2005) (48)
- Proteasome inhibitors protect against degeneration of nigral dopaminergic neurons in hemiparkinsonian rats. (2005) (46)
- Ras-dependent and Ras-independent activation pathways for the stress-activated-protein-kinase cascade. (1996) (46)
- Assessment of protein kinase C isozymes by two‐site enzyme immunoassay in human brains and changes in Alzheimer's disease (1993) (46)
- BDNF is induced by wild-type alpha-synuclein but not by the two mutants, A30P or A53T, in glioma cell line. (2004) (45)
- Differential Expression of Small Heat Shock Proteins in Reactive Astrocytes after Focal Ischemia: Possible Role of β-Adrenergic Receptor (1999) (45)
- Apoptotic cell death in neurons and glial cells: implications for Alzheimer's disease. (1999) (44)
- Presenilin 1 mediates retinoic acid‐induced differentiation of SH‐SY5Y cells through facilitation of Wnt signaling (2003) (44)
- Activity-dependent regulation of beta-catenin via epsilon-cleavage of N-cadherin. (2006) (44)
- Presenilin 1 is involved in maturation and trafficking of N‐cadherin to the plasma membrane (2003) (43)
- Protein disulfide isomerase in Alzheimer disease. (2000) (43)
- Role of high mobility group protein-1 (HMG1) in amyloid-beta homeostasis. (2003) (42)
- Homer 1a enhances spike‐induced calcium influx via L‐type calcium channels in neocortex pyramidal cells (2005) (42)
- Phospholipase C isozymes in the human brain and their changes in Alzheimer's disease (1997) (42)
- Gluten sensitivity in Japanese patients with adult-onset cerebellar ataxia. (2006) (41)
- An IP3‐assisted form of Ca2+‐induced Ca2+ release in neocortical neurons (2000) (41)
- Variations in the BDNF Gene in Autopsy-Confirmed Alzheimer’s Disease and Dementia with Lewy Bodies in Japan (2006) (41)
- Neuroprotective Mechanisms of Antiparkinsonian Dopamine D2-Receptor Subfamily Agonists (2003) (40)
- Improvement of focal ischemia-induced rat dopaminergic dysfunction by striatal transplantation of mouse embryonic stem cells (2006) (40)
- Association of novel and established polymorphisms in neuronal nicotinic acetylcholine receptors with sporadic Alzheimer's disease. (2002) (40)
- Inferior Temporal Lobe Atrophy and APOE Genotypes in Alzheimer’s Disease (1998) (40)
- Novel neuroprotective mechanisms of pramipexole, an anti-Parkinson drug, against endogenous dopamine-mediated excitotoxicity. (2007) (40)
- Alpha7 nicotinic acetylcholine receptor-specific agonist DMXBA (GTS-21) attenuates Aβ accumulation through suppression of neuronal γ-secretase activity and promotion of microglial amyloid-β phagocytosis and ameliorates cognitive impairment in a mouse model of Alzheimer's disease (2018) (39)
- 3‐[(2,4‐dimethoxy)benzylidene]‐anabaseine dihydrochloride protects against 6‐hydroxydopamine‐induced parkinsonian neurodegeneration through α7 nicotinic acetylcholine receptor stimulation in rats (2013) (39)
- Protocols to demonstrate slowing of Alzheimer disease progression. Position paper from the International Working Group on Harmonization of Dementia Drug Guidelines. The Disease Progression Sub-Group. (1997) (39)
- A distinct form of calcium release down-regulates membrane excitability in neocortical pyramidal cells (2002) (39)
- Differential expression of protein kinase C isozymes in rat glial cell cultures (1991) (39)
- Involvement of Wiskott-Aldrich syndrome protein family verprolin-homologous protein (WAVE) and Rac1 in the phagocytosis of amyloid-beta(1-42) in rat microglia. (2003) (39)
- Estrogens and parkinson disease (2003) (38)
- Heat shock protein-90-induced microglial clearance of exogenous amyloid-β1–42 in rat hippocampus in vivo (2003) (38)
- Reactive oxygen: its sources and significance in Alzheimer disease. (2002) (38)
- Dopamine facilitates alpha-synuclein oligomerization in human neuroblastoma SH-SY5Y cells. (2010) (37)
- Continuation of Exercise Is Necessary to Inhibit High Fat Diet-Induced β-Amyloid Deposition and Memory Deficit in Amyloid Precursor Protein Transgenic Mice (2013) (37)
- High Fat Diet Enhances β-Site Cleavage of Amyloid Precursor Protein (APP) via Promoting β-Site APP Cleaving Enzyme 1/Adaptor Protein 2/Clathrin Complex Formation (2015) (35)
- [3H]N‐[1‐(2‐Thienyl)cyclohexyl]‐3,4‐Piperidine ([3H]TCP) Binding in Human Frontal Cortex: Decreases in Alzheimer‐Type Dementia (1990) (35)
- The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer’s disease (2015) (35)
- Analysis of brain proteins in Alzheimer’s disease using high-resolution two-dimensional gel electrophoresis (1999) (35)
- Iron accelerates the conversion of dopamine‐oxidized intermediates into melanin and provides protection in SH‐SY5Y cells (2005) (34)
- Hyperbilirubinemia protects against focal ischemia in rats (2003) (34)
- Differential subcellular localization of caspase family proteins in the adult rat brain (2001) (34)
- Possible Involvement of Small Oligomers of Amyloid-β Peptides in 15-Deoxy-Δ12,14 Prostaglandin J2-Sensitive Microglial Activation (2003) (34)
- Prevention protocols for Alzheimer disease. Position paper from the International Working Group on Harmonization of Dementia Drug Guidelines. (1997) (33)
- α7 nicotinic acetylcholine receptor mediated neuroprotection in Parkinson's disease. (2012) (33)
- Mutations in LGI1 gene in Japanese families with autosomal dominant lateral temporal lobe epilepsy: The first report from Asian families (2010) (33)
- Eculizumab improves fatigue in refractory generalized myasthenia gravis (2019) (32)
- Involvement of WAVE accumulation in Abeta/APP pathology-dependent tangle modification in Alzheimer's disease. (2009) (31)
- Latitude and HLA-DRB1*04:05 independently influence disease severity in Japanese multiple sclerosis: a cross-sectional study (2016) (31)
- Synergistic effect of galantamine on nicotine-induced neuroprotection in hemiparkinsonian rat model (2008) (31)
- Amyloid β inhibits ectodomain shedding of N-cadherin via down-regulation of cell-surface NMDA receptor (2007) (31)
- Presence of calpain II immunoreactivity in senile plaques in Alzheimer's disease (1991) (30)
- High mobility group box protein-1 inhibits microglial Abeta clearance and enhances Abeta neurotoxicity. (2004) (30)
- Characterization of muscarinic cholinergic receptors in human and dog cerebral arteries. (1986) (29)
- Oxidation and interaction of DJ-1 with 20S proteasome in the erythrocytes of early stage Parkinson’s disease patients (2016) (29)
- Differential expression of protein kinase C isozymes in rat cerebellum. (1990) (29)
- Mechanism of resistance to NO‐induced neurotoxicity in cultured rat dopaminergic neurons (1996) (29)
- Serofendic acid prevents 6‐hydroxydopamine‐induced nigral neurodegeneration and drug‐induced rotational asymmetry in hemi‐parkinsonian rats (2005) (29)
- Nitric oxide donor-induced p53-sensitive cell death is enhanced by Bcl-2 reduction in human neuroblastoma cells (1998) (29)
- Novel G16S (GGC‐AGC) mutation in the SOD‐1 gene in a patient with apparently sporadic young‐onset amyotrophic lateral sclerosis (1997) (29)
- Intravenous mesenchymal stem cell administration exhibits therapeutic effects against 6-hydroxydopamine-induced dopaminergic neurodegeneration and glial activation in rats (2015) (28)
- Phosphatidylinositol-specific phospholipase C activity in the postmortem human brain: no alteration in Alzheimer's disease (1992) (28)
- Temporal changes of CD68 and α7 nicotinic acetylcholine receptor expression in microglia in Alzheimer's disease-like mouse models. (2015) (28)
- Early administration of galantamine from preplaque phase suppresses oxidative stress and improves cognitive behavior in APPswe/PS1dE9 mouse model of Alzheimer's disease. (2019) (28)
- Alteration of Phospholipase C‐δ Protein Level and Specific Activity in Alzheimer's Disease (1995) (27)
- Reduction of low‐molecular‐ weight acid phosphatase activity in Alzheimer brains (1993) (27)
- Characterization of beta adrenergic receptors in human cerebral arteries and alteration of the receptors after subarachnoid hemorrhage. (1986) (26)
- Transplantation of Mesenchymal Stem Cells Improves Amyloid-β Pathology by Modifying Microglial Function and Suppressing Oxidative Stress (2019) (26)
- Proteome analysis of brain proteins in Alzheimer's disease: subproteomics following sequentially extracted protein preparation. (2004) (26)
- Differential involvement of small G proteins in Alzheimer's disease. (1999) (25)
- Long‐term effect of bone marrow transplantation in adult‐onset adrenoleukodystrophy (2005) (25)
- Colocalization of 14-3-3 Proteins with SOD1 in Lewy Body-Like Hyaline Inclusions in Familial Amyotrophic Lateral Sclerosis Cases and the Animal Model (2011) (25)
- Possible Involvement of ER Chaperone Grp78 on Reduced Formation of Amyloid‐β Deposits (2002) (25)
- Analysis of the Proteomic Profiling of Brain Tissue in Alzheimer's Disease (2002) (24)
- Presenilin 1 is involved in the maturation of β‐site amyloid precursor protein‐cleaving enzyme 1 (BACE1) (2007) (24)
- Leu106→Val (CTC→GTC) mutation of superoxide dismutase-1 gene in patient with familial amyotrophic lateral sclerosis in Japan (1994) (24)
- Alteration of myo-inositol monophosphatase in Alzheimer's disease brains (1998) (23)
- Distribution of the 4F2 light chain, LAT1, in the mouse brain (2000) (23)
- Abnormal accumulation of phospholipase C-δ in filamentous inclusions of human neurodegenerative diseases (1993) (23)
- Role of Suppressor of Cytokine Signaling 3 (SOCS3) in Altering Activated Microglia Phenotype in APPswe/PS1dE9 Mice. (2016) (23)
- Reduction of Platelet Phospholipase C Activity in Patients with Alzheimer Disease (1995) (22)
- Possible involvement of Wiskott–Aldrich syndrome protein family in aberrant neuronal sprouting in Alzheimer's disease (2003) (22)
- Platelet Protein Kinase C levels in Alzheimer's disease (1994) (22)
- Patch sensor detection of glutamate release evoked by a single electrical shock (1995) (22)
- Inhibitory effects of antiparkinsonian drugs and caspase inhibitors in a parkinsonian flatworm model. (2003) (22)
- ‘Minimal symptom expression’ in patients with acetylcholine receptor antibody-positive refractory generalized myasthenia gravis treated with eculizumab (2020) (22)
- The spectrum of clinicopathological features in pure autonomic neuropathy (2012) (21)
- N‐cadherin enhances APP dimerization at the extracellular domain and modulates Aβ production (2011) (21)
- N‐cadherin‐based adhesion enhances Aβ release and decreases Aβ42/40 ratio (2009) (21)
- Roles of Nicotinic Acetylcholine Receptors in the Pathology and Treatment of Alzheimer’s and Parkinson’s Diseases (2018) (21)
- Tipping the apoptotic balance in Alzheimer's disease (2007) (21)
- Emergence of a functional coupling between inositol-1,4,5-trisphosphate receptors and calcium channels in developing neocortical neurons (2002) (20)
- Biochemical characterization of alpha-adrenergic receptors in human brain and changes in Alzheimer-type dementia. (1986) (19)
- Neuroprotective effect of cyclic GMP against radical‐induced toxicity in cultured spinal motor neurons (2000) (19)
- Changes in signal transduction in Alzheimer's disease. (1990) (19)
- Dural arteriovenous fistula in a case of dementia with bithalamic MR lesions (2008) (19)
- Changes of neurocalcin, a calcium-binding protein, in the brain of patients with Alzheimer' s disease (1996) (19)
- Localization of protein kinase C in human skeletal muscle (1992) (18)
- Neuronal damage in the rat hippocampus induced by in vivo hypoxia. (1993) (18)
- Clinicopathologic Features of Oculopharyngodistal Myopathy With LRP12 CGG Repeat Expansions Compared With Other Oculopharyngodistal Myopathy Subtypes. (2021) (18)
- The 4 F 2 hc / LAT 1 complex transports L-DOPA across the blood – brain barrier (2000) (18)
- Presynaptic and postsynaptic alpha 2-adrenergic receptors in human cerebral arteries and their alteration after subarachnoid hemorrhage. (1988) (18)
- Characterization of the association of phospholipase C-δ with Alzheimer neurofibrillary tangles (1995) (18)
- Expression of protein kinase C isozymes in primary neuronal cultures of the rat cerebellum (1991) (18)
- In vivo hypoxia-induced neuronal damage in dentate gyrus of rat hippocampus: changes in NMDA receptors and the effect of MK–801 (1997) (18)
- A novel nuclear DnaJ protein, DNAJC8, can suppress the formation of spinocerebellar ataxia 3 polyglutamine aggregation in a J-domain independent manner. (2016) (18)
- Protein trafficking and Alzheimer's disease. (2004) (18)
- Effects of nicotinic receptor agonists on beta-amyloid beta-sheet formation. (1999) (17)
- Possible involvement of small oligomers of amyloid-beta peptides in 15-deoxy-delta 12,14 prostaglandin J2-sensitive microglial activation. (2003) (17)
- The endogenous substrate of low molecular weight acid phosphatase in the brain is an epidermal growth factor receptor (1994) (17)
- Signal transduction mechanisms in Alzheimer disease. (1995) (17)
- Improvement of central motor conduction after bone marrow transplantation in adrenoleukodystrophy (2003) (17)
- Increase in phospholipase C-delta1 protein levels in aluminum-treated rat brains. (2000) (17)
- Contribution of anti-ryanodine receptor antibody to impairment of excitation–contraction coupling in myasthenia gravis (2012) (17)
- Therapeutic effects of human mesenchymal and hematopoietic stem cells on rotenone‐treated parkinsonian mice (2012) (16)
- Occipital Neuralgia Evoked by Facial Herpes Zoster Infection (2006) (16)
- Correlation of bite force with excitation–contraction coupling time of the masseter in myasthenia gravis (2010) (16)
- Cocaine and phenylephrine eye drop test for Parkinson disease. (2005) (16)
- Pharmacological characteristics of rotational behavior in hemiparkinsonian rats transplanted with mouse embryonic stem cell-derived neurons. (2004) (16)
- HLA genotype-clinical phenotype correlations in multiple sclerosis and neuromyelitis optica spectrum disorders based on Japan MS/NMOSD Biobank data (2021) (16)
- Transport and toxic mechanism for aluminum citrate in human neuroblastoma SH-SY5Y cells. (2006) (16)
- Methylphenylpyridium ion (MPP+) enhances glutamate-induced cytotoxicity against dopaminergic neurons in cultured rat mesencephalon. (1994) (16)
- Early effect of tacrolimus in improving excitation–contraction coupling in myasthenia gravis (2012) (16)
- Indication of a protein kinase C-independent pathway for NADPH oxidase activation in human neutrophils. (1998) (16)
- Enhancement of nicotinic receptors alleviates cytotoxicity in neurological disease models (2011) (15)
- Changes in platelet phospholipase C protein level and activity in Alzheimer's disease (1995) (15)
- Latitude and HLA-DRB1 alleles independently affect the emergence of cerebrospinal fluid IgG abnormality in multiple sclerosis (2015) (15)
- CD14 and Toll-Like Receptor 4 Promote Fibrillar Aβ42 Uptake by Microglia Through A Clathrin-Mediated Pathway. (2019) (15)
- A novel lamin A/C gene mutation causing spinal muscular atrophy phenotype with cardiac involvement: report of one case (2015) (15)
- Nicotinic Acetylcholine Receptor Signaling in Neuroprotection (2018) (15)
- Response of serum carboxylated and undercarboxylated osteocalcin to risedronate monotherapy and combined therapy with vitamin K(2) in corticosteroid-treated patients: a pilot study. (2010) (15)
- Ictal monoparesis associated with lesions in the primary somatosensory area (2005) (15)
- Fingolimod induces BAFF and expands circulating transitional B cells without activating memory B cells and plasma cells in multiple sclerosis. (2017) (15)
- Respiratory insufficiency with preserved diaphragmatic function in amyotrophic lateral sclerosis. (2014) (15)
- Tyrosine phosphorylation and translocation of phospholipase C-gamma 2 in polymorphonuclear leukocytes treated with pervanadate. (1996) (14)
- Gain of function by phosphorylation in Presenilin 1‐mediated regulation of insulin signaling (2012) (14)
- Transplantation of mouse embryonic stem cell-derived neurons into the striatum, subthalamic nucleus and substantia nigra, and behavioral recovery in hemiparkinsonian rats (2005) (14)
- Effect of in vivo exposure to hypoxia on muscarinic cholinergic receptor-coupled phosphoinositide turnover in the rat brain (1989) (14)
- Thyrotoxic myopathy mimicking myasthenic syndrome associated with thymic hyperplasia. (2008) (14)
- Alterations of low molecular weight acid phosphatase protein level in Alzheimer's disease (1995) (14)
- Genetic variation in the ciliary neurotrophic factor receptor α gene and familial amyotrophic lateral sclerosis (1998) (14)
- Clinical outcome of patients with SREDA (subclinical rhythmic EEG discharge of adults). (2006) (14)
- Roles of microglia in alzheimer's disease and impact of new findings on microglial heterogeneity as a target for therapeutic intervention. (2021) (14)
- Differential involvement of phospholipase C isozymes in Alzheimer's disease. (1995) (14)
- Possible Protective Mechanisms of Heme Oxygenase‐1 in the Brain (2002) (14)
- SIRT1 deficiency interferes with membrane resealing after cell membrane injury (2019) (13)
- α4 nicotinic acetylcholine receptor modulated by galantamine on nigrostriatal terminals regulates dopamine receptor-mediated rotational behavior (2016) (13)
- A heterozygous missense mutation in adolescent-onset very long-chain acyl-CoA dehydrogenase deficiency with exercise-induced rhabdomyolysis. (2015) (13)
- Effects of a DJ-1-Binding Compound on Spatial Learning and Memory Impairment in a Mouse Model of Alzheimer's Disease. (2016) (13)
- Progressive multifocal leukoencephalopathy after autologous peripheral blood stem cell transplantation in a patient with multiple myeloma treated with combination therapy (2016) (13)
- Glutamate‐induced antigenic changes of phospholipase C‐δ in cultured cortical neurons (1995) (12)
- Effects of hyperoxia and acrylonitrile on the phospholipase C isozyme protein levels in rat heart and brain. (2003) (12)
- Differential expression of rat brain phospholipase C isozymes in development and aging. (1998) (12)
- Mutation in the pleckstrin homology domain of the human phospholipase C-delta 1 gene is associated with loss of function. (1998) (12)
- Changes in protein kinase C isozymes in the rat hippocampal formation following hippocampal lesion (1993) (12)
- Long-term efficacy and safety of eculizumab in Japanese patients with generalized myasthenia gravis: A subgroup analysis of the REGAIN open-label extension study (2019) (12)
- Zinc-ion-dependent acid phosphatase exhibits magnesium-ion-dependent myo-inositol-1-phosphatase activity. (1996) (11)
- Assessment of protein kinase C mRNA levels in Alzheimer's disease brains. (1996) (11)
- A new form of congenital proprioceptive sensory neuropathy associated with arthrogryposis multiplex (2004) (11)
- Selective induction of glial glutamate transporter GLT-1 by hypertonic stress in C6 glioma cells. (1999) (11)
- Intracellular receptors for activated C-kinase in the postmortem human brain: no alteration in Alzheimer disease. (1998) (11)
- Protective effect of serofendic acid on glutamate-induced neurotoxicity in rat cultured motor neurons (2005) (11)
- Changes in protein kinase C isozymes in the rat hippocampus following transient hypoxia (1993) (11)
- Abundance of low molecular weight phosphotyrosine protein phosphatase in the nerve-ending fraction in the brain. (1999) (11)
- "Burst and slow complexes" in nonconvulsive epileptic status. (2006) (11)
- α-Synuclein protein is not scavenged in neuronal loss induced by kainic acid or focal ischemia (2001) (11)
- Opposing effects of adenosine on the survival of glial cells exposed to chemical ischemia (2000) (10)
- Developmental expression of neural Wiskott–Aldrich syndrome protein (N-WASP) and WASP family verprolin-homologous protein (WAVE)-related proteins in postnatal rat cerebral cortex and hippocampus (2006) (10)
- Changes in beta-adrenergic receptor subtypes in Alzheimer-type dementia. (1987) (9)
- Different Modulation of Protein Kinase C Isozymes in Dibutyryl Cyclic AMP‐Differentiated PC12h Cells (1994) (9)
- Alpha1-chimaerin, a Rac1 GTPase-activating protein, is expressed at reduced mRNA levels in the brain of Alzheimer's disease patients (2015) (9)
- Fingolimod suppresses bone resorption in female patients with multiple sclerosis (2016) (9)
- Aberrant Phosphoinositide Metabolism in Alzheimer's Disease a (1993) (9)
- [An adult case of transverse myelitis with erythema infectiosum]. (1992) (9)
- Reduction of platelet phospholipase C-delta1 activity in Alzheimer's disease associated with a specific apolipoprotein E genotype (epsilon3/epsilon3). (1998) (9)
- The Role of the Presenilin-1 Homologue Gene sel-12 ofCaenorhabditis elegans in Apoptotic Activities* (2003) (8)
- Sympathetic denervation and alpha adrenoceptors in dog cerebral arteries (1986) (8)
- Alteration of human platelet protein kinase C with normal aging (1993) (8)
- Differences in rotational asymmetry in rats caused by single intranigral injections of 6-hydroxydopamine, 1-methyl-4-phenylpyridinium ion and rotenone (2002) (8)
- [Sporadic adult-onset neuronal intranuclear inclusion disease with abnormal electroretinogram, nerve conduction studies and somatosensory evoked potential]. (2018) (8)
- Efficacy and Safety of Ultrahigh-Dose Methylcobalamin in Early-Stage Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial. (2022) (8)
- Anti‐ryanodine receptor–positive acetylcholine receptor–negative myasthenia gravis: Evidence of impaired excitation–contraction coupling (2011) (8)
- Mouse Bone Marrow-derived Microglia-like Cells Secrete Transforming Growth Factor-β1 and Promote Microglial Aβ Phagocytosis and Reduction of Brain Aβ (2020) (8)
- P3-385 Presenilin 1 is involved in the maturation of beta-site amyloid precursor protein-cleaving enzyme 1(BACE1) (2006) (8)
- Kainic acid-induced neuronal loss and glial changes in the hippocampal CA3 of p53-deficient mouse (1998) (8)
- Clinical and Radiological Characteristics of Intracranial Artery Dissection Using Recently Proposed Diagnostic Criteria. (2019) (8)
- 713 Changes in Ca2+-dependent and -independent protein kinase C in Alzheimer's Disease (1996) (7)
- Evaluation of Mitochondrial Oxidative Stress in the Brain of a Transgenic Mouse Model of Alzheimer's Disease by in vitro Electron Paramagnetic Resonance Spectroscopy. (2019) (7)
- Preparation and Characterization of Microglia-Like Cells Derived from Rat, Mouse, and Human Bone Marrow Cells for Therapeutic Strategy of Alzheimer's Disease (2011) (7)
- A case of neuromyelitis optica presenting marked pleocytosis and hypoglycorrhachia. (2016) (7)
- Hypersomnia caused by isolated angiitis of the CNS. (2005) (7)
- Effect of local cooling on excitation-contraction coupling in myasthenic muscle: Another mechanism of ice-pack test in myasthenia gravis (2017) (7)
- MPP(+) and glutamate in the degeneration of nigral dopaminergic neurons. (1999) (6)
- P4-262: N-cadherin–based adhesion enhances Abeta release and decreases Abeta42/40 ratio (2008) (6)
- The binding of 3H-acetylcholine to cholinergic receptors in bovine cerebral arteries. (1985) (6)
- Epileptic polyopia with right temporal lobe epilepsy as studied by FDG-PET and MRI: A case report (2006) (6)
- Participation of cytosolic protein phosphatase in regulation of NADPH oxidase in polymorphonuclear leukocytes. (1999) (6)
- Alteration of phospholipase C-delta protein level and specific activity in Alzheimer's disease. (1995) (6)
- Protein degradation in Alzheimer's disease and aging of the brain. (2002) (6)
- Apoptotic and Oxidative Indicators in Alzheimer’s Disease (2002) (6)
- Development of moyamoya disease after non-herpetic acute limbic encephalitis: A case report (2018) (6)
- ANCA-negative granulomatosis with polyangiitis presenting with orbital apex syndrome and recurrent pachymeningitis: A case report (2016) (6)
- Reassessment of [3H]glutamate binding to human brain membrane preparations. (1991) (6)
- Fisher syndrome with delayed facial weakness and taste impairment: a case report. (2016) (5)
- Establishing a New Screening System for Mild Cognitive Impairment and Alzheimer's Disease with Mental Rotation Tasks that Evaluate Visuospatial Function. (2018) (5)
- Research report Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in Alzheimer's disease (1998) (5)
- Multiple system atrophy in Hokkaido, Japan: a prospective registry study of natural history and symptom assessment scales followed for 5 years (2021) (5)
- Streptococcus oralis Meningitis with Gingival Bleeding in a Patient: A Case Report and Review of the Literature (2020) (5)
- Generation of striatal neurons from human induced pluripotent stem cells by controlling extrinsic signals with small molecules. (2021) (5)
- Long-term clinical and radiological improvement of chronic acquired hepatocerebral degeneration after obliteration of portosystemic shunt: Report of a case (2014) (5)
- PI3K inhibition causes the accumulation of ubiquitinated presenilin 1 without affecting the proteasome activity. (2010) (5)
- Transient oculomotor palsy correlated with nerve enhancement on MRI in chronic inflammatory demyelinating polyneuropathy. (2009) (5)
- Nicotinic Acetylcholine Receptors and Microglia as Therapeutic and Imaging Targets in Alzheimer’s Disease (2022) (4)
- An Anti-PM/Scl-75 Antibody-positive Japanese Woman Who Developed Inflammatory Myopathy (2019) (4)
- Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients (2022) (4)
- [Apolipoprotein E polymorphism in Alzheimer's disease]. (1996) (4)
- Severe Mononeuritis Multiplex due to Rheumatoid Vasculitis in Rheumatoid Arthritis in Sustained Clinical Remission for Decades (2019) (4)
- Depletion of intracellular glutathione increases susceptibility to nitric oxide in mesencephalic dopamine neurons (1998) (4)
- Early detection of redox imbalance in the APPswe/PS1dE9 mouse model of Alzheimer's disease by in vivo electron paramagnetic resonance imaging. (2021) (4)
- SIRT1 decelerates morphological processing of oligodendrocyte cell lines and regulates the expression of cytoskeleton-related oligodendrocyte proteins. (2021) (4)
- Ischemic Stroke with Protein S Deficiency Treated by Apixaban. (2020) (4)
- Differential expression profiles of PLC-β1 and -δ1 in primary cultured rat cortical neurons treated with N-methyl-d-aspartate and peroxynitrite (2004) (4)
- Possible involvement of rapamycin-sensitive pathway in Bcl-2 expression in human neuroblastoma SH-SY5Y cells. (1997) (4)
- Analysis of resources assisting in coping with swallowing difficulties for patients with Parkinson’s disease: a cross-sectional study (2016) (4)
- [Anti-dementia drugs]. (2012) (3)
- Impaired post-tetanic potentiation of muscle twitch in myasthenia gravis (2016) (3)
- The Application of Proteomics in Neurology (2005) (3)
- [Dramatic seizure reduction with levetiracetam in adult Dravet syndrome: a case report]. (2015) (3)
- Short Communication Involvement of WAVE Accumulation in A/APP Pathology-Dependent Tangle Modification in Alzheimer's Disease (2009) (3)
- 40 Nicotinic agonists prevent neuronal cell death by glutamate and amyloid beta protein (1996) (3)
- Possible Somatic Mosaicism of Novel FUS Variant in Familial Amyotrophic Lateral Sclerosis (2021) (3)
- Alterations of phospholipase C isozymes in rat cerebral cortex through hyperoxia. (2001) (3)
- Intracerebral grafting of genetically modified cells. Applications to a rat model of Parkinson's disease. (1993) (3)
- Characterization of high- and low-molecular weight zinc-dependent acid phosphatases in bovine liver. (1998) (3)
- Substrate-Specific Stimulation by Glucagon of Isolated Murine Brain Mitochondrial Oxidative Phosphorylation (2005) (3)
- [Treatment outcome of patients with cranial base lesions of unknown etiology: focusing on infectious cases with multiple cranial nerve disorders]. (2013) (3)
- The Japanese Early-Stage Trial of High-Dose Methylcobalamin for Amyotrophic Lateral Sclerosis (JETALS): Protocol for a Randomized Controlled Trial (2018) (2)
- A New Aspect of Cholinergic Transmission in the Central Nervous System -- Nicotinic Acetylcholine Receptor Signaling in Neuroprotection (2018) (2)
- [Non-Convulsive Status Epilepticus Caused by Hyponatremia in an Elderly Woman: A Case Report]. (2017) (2)
- HIGH MOLECULAR WEIGHT NEUROFILAMENT PROTEINS (2001) (2)
- Differential expression profiles of PLC-beta1 and -delta1 in primary cultured rat cortical neurons treated with N-methyl-D-aspartate and peroxynitrite. (2004) (2)
- Myopericarditis in a case of anti-signal recognition particle (anti-SRP) antibody-positive myopathy. (2016) (2)
- P2-52. Respiratory impairment with preserved diaphragmatic function in ALS (2013) (2)
- Morphological change by overexpression of D385A dominant negative presenilin 1 in human neuroblastoma SH-SY5Y cells. (2006) (2)
- [Neuronal cell death in neurodegenerative disorders and oxidative stress]. (1999) (2)
- Oculopharyngeal muscular dystrophy with marked clinical fluctuations mimicking myasthenia gravis: A case report (2014) (2)
- Hyperemesis-induced Wernicke-Korsakoff Syndrome due to Hypergastrinemia during Long-term Treatment with Proton Pump Inhibitors (2020) (2)
- The hydroxyl radical formation system in polymorphonuclear leukocytes. (1999) (2)
- Animal Models of Parkinson’s Disease Induced by Toxins and Genetic Manipulation (2012) (1)
- [Changes in apoptosis-regulating proteins in Alzheimer's disease: comparison with development and aging]. (2000) (1)
- [Lewy bodies: neuroprotective?]. (2006) (1)
- [A case with temporal lobe epilepsy associated with hypocalcemia due to primary hypoparathyroidism]. (2006) (1)
- Nicotinic Acetylcholine Receptor Signaling: Roles in Neuroprotection -- Nicotinic Acetylcholine Receptor Signaling in Neuroprotection (2018) (1)
- [A case of Charcot-Marie-Tooth disease type 2Z caused by MORC2 S87L mutation mimicking spinal muscular atrophy]. (2021) (1)
- BiP/GRP78-Induced Microglial Activation and Increase of Aß Clearance (2002) (1)
- A Cross-Sectional Study on Socioeconomic Systems Supporting Outpatients With Parkinson's Disease in Japan. (2016) (1)
- In Vivo Imaging of Nicotinic Acetylcholine Receptors in the Central Nervous System -- Nicotinic Acetylcholine Receptor Signaling in Neuroprotection (2018) (1)
- Characterization of the association of phospholipase C-delta with Alzheimer neurofibrillary tangles. (1995) (1)
- [Treatment of Alzheimer's disease: status quo and future considerations]. (2008) (1)
- Nicotinic receptor stimulation is protective for dopaminergic neuron (2007) (1)
- [A case of facial-onset sensory and motor neuronopathy (FOSMN) with cerebellar ataxia and abnormal decrement in repetitive nerve stimulation test]. (2021) (1)
- Coexistence of 2 different type I repeats. (2001) (1)
- [Focal cortical dysplasia at the primary somatosensory cortex could manifest both intractable partial epilepsy and cortical reflex myoclonus]. (2006) (1)
- Transplantation of rat bone marrow-derived mesenchymal stem cells regulates oxidative stress in Alzheimer’s disease transgenic mouse model (2017) (1)
- Alteration of Transcription Factors NF-κB and STAT1 in Alzheimer’s Disease Brains (1998) (1)
- Endovascular thrombectomy and left atrial appendage evaluation for recurrent cerebral embolism case with atrial fibrillation early after administration of intravenous tissue plasminogen activator (2020) (1)
- Load effect on background rhythms during motor execution: A magnetoencephalographic study (2016) (1)
- Sporadic Amyotrophic Lateral Sclerosis Due to a FUS P525L Mutation with Asymmetric Muscle Weakness and Anti-ganglioside Antibodies (2021) (1)
- [Unilateral ptosis induced by pure midbrain infarction: a case report]. (2020) (1)
- 429 Neuroprotective effect of nicotine against beta amyloid cytotoxicity (1996) (1)
- Neuronal Survival and Death in Alzheimer Disease (2002) (1)
- myo-Inositol monophosphatase in the brain has zinc ion-dependent tyrosine phosphatase activity. (1998) (1)
- Shati/Nat8l and N-acetylaspartate (NAA) Have Important Roles in Regulating Nicotinic Acetylcholine Receptors in Neuronal and Psychiatric Diseases in Animal Models and Humans -- Nicotinic Acetylcholine Receptor Signaling in Neuroprotection (2018) (1)
- ER-stress and autophagy regulation of nicotine-mediated neuroprotection in a mouse model of Parkinson's disease (2011) (1)
- Overview -- Nicotinic Acetylcholine Receptor Signaling in Neuroprotection (2018) (1)
- [A case of dural arteriovenous fistula of right cavernous sinus presenting bilateral eye symptoms]. (2015) (1)
- [A case of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) complicated by chronic intestinal pseudo-obstruction]. (2022) (1)
- 251 Genetic analysis of a catalytic domain of phospholipase C-δ1 in patients with Alzheimer's disease (1996) (0)
- 2.441 Nicotine provides protective effects in dopaminergic neurons via the nicotinic receptors (2007) (0)
- [A case of secondary hemochromatosis with polyneuropathy]. (1983) (0)
- Cytosolic SIRT3 protects PC12 cells against amyloid beta toxicity (2017) (0)
- Latitude and HLA-DRB1 alleles independently affect the emergence of cerebrospinal fluid IgG abnormalities in multiple sclerosis (P2.214) (2015) (0)
- N-cadherin enhances extracellular secretion of Aβ (2007) (0)
- Beta adrenergic receptor subtypes in senile dementia of the alzheimer-type (1987) (0)
- Effects of hypoxia on muscarinic receptors in rat brain (1987) (0)
- The Japanese Early-Stage Trial of High-Dose Methylcobalamin for Amyotrophic Lateral Sclerosis (JETALS): Protocol for a Randomized Controlled Trial (Preprint) (2018) (0)
- Neuroprotective effects of nicotic receptor stimulation by ER stress and autophagy regulation (2009) (0)
- P2-f16 A free radical scavenger, Edaravone, protects cerebral microvascular integrity after tissue plasminogen activator adminis- tration in a rat stroke model (2018) (0)
- P-PN007. A case presenting with clinical and laboratory characteristics of fisher syndrome and lambert-eaten myasthenic syndrome (LEMS) (2021) (0)
- レチノイン酸によって分化したヒト神経芽細胞腫SH-SY5Y細胞におけるクエン酸アンモニウム輸送体の特徴づけ(原標題は英語) (2003) (0)
- Decreased level of Protein Kinase C in brains with ALZHEIMER'S DISEASE. (1991) (0)
- Title The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer ' s disease (2016) (0)
- Decision making of using invasive mechanical ventilation in patients with amyotrophic lateral sclerosis in Sapporo (2017) (0)
- [A case of Marchiafava-Bignami disease suggesting vasogenic edema]. (2016) (0)
- P4-315 The cell biology of presenilin 1-mediated cleavage of N-cadherin (2004) (0)
- Title Page / Table of Contents, Supplement 1, 1995 (1995) (0)
- A Case of Sporadic Amyotrophic Lateral Sclerosis Due to a FUS P525L Mutation with Asymmetric Muscle Weakness and Anti-ganglioside Antibodie (2021) (0)
- D2 Receptor Stimulation Protects Mesencephalic Neurons from Glutamate-Induced Cytotoxicity (1997) (0)
- Abrupt Onset of Cardiac Tamponade in Sarcoidosis A Serious but Steroid-Responsive Complication (2021) (0)
- Neuroprotective Effects of Estrogen in Nigral Dopaminergic Neurons (2001) (0)
- Aβ/APP-dependent tangle modification via WAVE accumulation in Alzheimer's disease (2010) (0)
- Successful intervention for overwhelming postsplenectomy infection caused by non-vaccine pneumococcal serotype 23A (2020) (0)
- Protocol The Japanese Early-Stage Trial of High-Dose Methylcobalamin for Amyotrophic Lateral Sclerosis ( JETALS ) : Protocol for a Randomized Controlled Trial (2018) (0)
- Oral Presentations OP01: Neurodegenerative Diseases (2008) (0)
- Reduced N-Methyl-D-Aspartate (NMDA) Receptor-Ion Channel Complex in Alzheimer’s Disease Frontal Cortex (1990) (0)
- Short communication Epileptic polyopia with right temporal lobe epilepsy as studied by FDG-PET and MRI: A case report (2006) (0)
- The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer’s disease (2015) (0)
- Establishment of a new screening system for MCI and AD with mental rotation tasks evaluating visuospatial function (2017) (0)
- [Development of therapies for Alzheimer's disease based on cholinergic hypothesis-status quo and future directions]. (2013) (0)
- EFFECTS OF IN VIVO EXPOSURE TO HYPOXIA ON NMDA AND MUSCARINIC CHOLINERGIC RECEPTORS IN RAT HIPPOCAMPUS (1992) (0)
- Deacetylase SIRTs regulate differentiation of oligodendrocyte and modulate distribution of oligodendrocyte-specific cytoskeleton-related molecules (2017) (0)
- Changes in low molecular weight acid phosphatase, a phosphotyrosine protein phosphatase, in Alzheimer brains (1995) (0)
- P4-266 Protective effects of nicotinic receptor stimulation with nicotine or acetylcholinesterase inhibitors against beta amyloid- or glutamate-induced neuronal death (2006) (0)
- Efficacy of galantamine treatment in very early stage of APPswe/PS1dE9 mice (2017) (0)
- Stroke team leadership over education for medical students and stroke care workers in the community (2010) (0)
- Microglial activation around amyloid-β deposits in mouse and rat models (2004) (0)
- Nicotinic Acetylcholine Receptors in Regulation of Pathology of Cerebrovascular Disorders -- Nicotinic Acetylcholine Receptor Signaling in Neuroprotection (2018) (0)
- Alterations of neurocalcin, a calcium-binding protein, in Alzheimer’s disease. (1996) (0)
- Stimulation of nicotinic acetylcholine receptor suppresses expression of CD14 in microglia (2017) (0)
- Corrigendum to “Intravenous mesenchymal stem cell administration exhibits therapeutic effects against 6-hydroxydopamine-induced dopaminergic neurodegeneration and glial activation in rats” [Neurosci. Lett. 584 (2015) 276–281] (2015) (0)
- 1214 Mechanisms of dopamine D2-induced neuroprotection against glutamate neurotoxicity in rat mesencephalon (1997) (0)
- Clearance of amyloid-β in microglial culture model (2004) (0)
- PS-54-7 Deletion and point mutations in the superoxide dismutase-1 gene in sporadic and familial amyotrophic lateral sclerosis (1995) (0)
- S 61-2 Pathological changes induced by amyloid-β in Alzheimer ' s disease ◯ (2010) (0)
- [Nucleus basalis of Meynert and cholinergic neurotransmission]. (2011) (0)
- Progress report of the registry study for multiple system atrophy in Hokkaido, Japan: HoRC-MSA project 2014-17 (2017) (0)
- Synergistic protection of dopamiergic neuron by an allosteric potentiating ligand (2010) (0)
- cross talk of intracellular signal transduction systems in dibutyryi cAMP-stimulated PC12h cells (1992) (0)
- The role of nicotinic acetylcholine receptors on differentiation of iPSC-derived macrophages and dopaminergic neurons (2021) (0)
- Removal of Blood Amyloid As a Therapeutic Strategy for Alzheimer’s Disease: The Influence of Smoking and Nicotine -- Nicotinic Acetylcholine Receptor Signaling in Neuroprotection (2018) (0)
- 1213 Protective effects of C2-ceramide against glutamate-induced neurotoxicity in cultured cortical neurons (1997) (0)
- 1230 Neuroprotective effect of nicotine-related substances against beta amyloid cytotoxicity (1997) (0)
- [Current concepts regarding cortical dementia]. (2015) (0)
- [Dementia: progress in diagnosis and treatment; Topics, I. Basic knowledge of dementia and pathophysiology; 1. The concept and pathophysiology of dementia of Alzheimer-type]. (2011) (0)
- α7 nicotinic acetylcholine receptor-specific stimulation ameliorates cognitive impairment in a mouse model of Alzheimer's disease via suppression of neuronal γ-secretase activity and promotion of microglial amyloid-β phagocytosis (2018) (0)
- Different roles of protein kinase C isozymes in differentiation of PC12h cells (1990) (0)
- The impairment of excitation-contraction coupling in icu-acquired weakness (2019) (0)
- 1. The Concept and Pathophysiology of Dementia of Alzheimer-type. (2011) (0)
- Regulation by Nicotinic Acetylcholine Receptors of Microglial Glutamate Transporters: Role of Microglia in Neuroprotection -- Nicotinic Acetylcholine Receptor Signaling in Neuroprotection (2018) (0)
- P1-481: Alpha 1-chimaerin protein can interact with beta-amyloid peptides and is expressed at reduced levels in Alzheimer's brain (2008) (0)
- Mesenchymal stem cell-conditioned medium induces microglia into M2 phenotype and promotes amyloid β-phagocytosis (2017) (0)
- [A case of neuronal intranuclear inclusion disease with serial MRI changes observed from before onset of forgetfulness]. (2021) (0)
- [Protein kinase C]. (1995) (0)
- Analysis of transendothelial migration of bone marrow-derived mesenchymal stem cells (2011) (0)
- 21. The correlation between excitation–contraction coupling time of the masseter and the bite force in myasthenia gravis (2009) (0)
- A Case that Showed Exacerbation of Intracranial Arterial Stenosis in the Chronic Phase after Percutaneous Intracranial Stent Retriever Thrombectomy (2017) (0)
- HLA genotype-clinical phenotype correlations in multiple sclerosis and neuromyelitis optica spectrum disorders based on Japan MS/NMOSD Biobank data (2021) (0)
- Title Exercise is more effective than diet control in preventing high fat diet-induced β-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice (2018) (0)
- Title Environmental enrichment ameliorated high-fat diet-induced Aβ deposition and memory deficit in APP transgenic mice (2020) (0)
- Functional regulation targeting nicotinic acetylcholine receptors using iPS cell-derived microglia (2022) (0)
- P4-013 N-cadherin cleavage by ADAM10 after NMDA receptor stimulation is inhibited amyloid-beta peptides (2006) (0)
- The optimal preconditioning for bone marrow transplantation to establish 6-OHDA-lesioned GFP bone marrow chimeric PD model rat (2017) (0)
- Amyloid-β-dependent tangle maturation in Alzheimer's disease (2010) (0)
- 1 Environmental enrichment ameliorated high fat diet-induced Aβ deposition and memory deficit in APP transgenic mice . (2019) (0)
- P946: Impairment of excitation-contraction coupling in myasthenia gravis: a new method using post-tetanic potentiation (2014) (0)
- [Therapy for Alzheimer-type dementia-status quo and future considerations]. (2013) (0)
- 716 Calpain (calcium-activated neutral proteinase) changes in the brain of Alzheimer's Disease (1996) (0)
- A case presenting electrophysiological and immunological characteristics of Fisher syndrome and Lambert‐Eaton myasthenic syndrome (2020) (0)
- Basic and Clinical lssues of Dementia (1996) (0)
- The Proteome in Neurodegenerative Diseases (2013) (0)
- 1336 Chronic d2 stimulation protects mesencephalic neurons from glutamate-induced euronal death (1996) (0)
- Apolipoprotein E genotyping in Japanese patients with Alzheimer's disease and vascular dementia (1994) (0)
- 24 - The Effect of Aging for Oxidative Stress in Mouse Brains by EPR Imaging Method (2014) (0)
- Latitude and HLA-DRB1*04:05 independently influence disease severity in Japanese multiple sclerosis: a cross-sectional study (2016) (0)
- Abstract WMP68: Clinical and Radiological Characteristics of Intracranial Artery Dissection Using Recently Proposed Diagnostic Criteria (2018) (0)
- [A case of atypical Tolosa-Hunt syndrome with a contrast enhanced lesion of the oculomotor and trigeminal nerves on MRI]. (2014) (0)
- Electrophysiological evaluation of peripheral neuropathies in hereditary spinocerebellar ataxia (2019) (0)
- Possible SomaticMosaicismofNovelFUSVariant in Familial Amyotrophic Lateral Sclerosis (0)
- Differential expression of protein kinase C -α and -βII in rat septum and changes following fimbria–fornix lesion (1998) (0)
- Ubiquitin-dependent rapid degradation conceals a cell-protective function of cytoplasmic SIRT3 against oxidative stress. (2020) (0)
- P-MU003. The impairment of excitation-contraction coupling in ICU-acquired weakness (2021) (0)
- Effects of nicotinic acetylcholine receptors on neurons, microglia, and bone marrow-derived microglia-like cells for the treatment of Alzheimer's disease. (2019) (0)
- Nicotinic Receptor Stimulation Blocks Neurotoxicity Induced by Amyloid-β via the Phosphatidylinositol-3-Kinase Cascade (2004) (0)
- Title Continuation of Exercise Is Necessary to Inhibit High Fat Diet- Induced β-Amyloid Deposition and Memory Deficit in Amyloid Precursor Protein Transgenic Mice (2018) (0)
- P4-371 Microglia and high mobility group box protein-1 in AD pathology (2006) (0)
- [A case of ankylosing spondylitis with spinal arachnoid diverticula]. (1984) (0)
- 242 Correlation between temporal lobe atrophy and APOE,ε4(+) genotype in Alzheimer's disease: X-ray CT and MRI studies (1996) (0)
- Expression of subforms of NAD+-dependent histone deacetylase SIRT3 in the brain (2009) (0)
- 3.128 Cardiac metaiodobenzylguanidine scintigraphy as a peripheral biomarker for the diagnosis of Parkinson's disease (2007) (0)
- [Two cases of photosensitive seizure induced by barcode readers with red flashing lights]. (2018) (0)
- Abrupt Onset of Cardiac Tamponade in Sarcoidosis. (2021) (0)
- [Morvan syndrome associated with unresectable thymoma responsive to chemotherapy: a case report]. (2022) (0)
- Correction to: Eculizumab improves fatigue in refractory generalized myasthenia gravis (2019) (0)
- Differential expression of protein kinase C -alpha and -betaII in rat septum and changes following fimbria-fornix lesion. (1998) (0)
- [Alterations in cholinergic and adrenergic receptors in senile dementia of the Alzheimer's-type]. (1986) (0)
- P3-091 Neuroproteomics in Alzheimer’s disease: Expression profiling of the brain proteomes and their relation to proteomes of body fluids (2006) (0)
- 1337 Brain-derived neurotrophic factor (bdnf) prevents nitric oxide (no)-mediated glutamate cytotoxicity (1996) (0)
- O-3-21. Electrophysiological evaluation of peripheral neuropathy in hereditary spinocerebellar ataxia (2018) (0)
- Rotenone mouse model of Parkinson's disease (2007) (0)
- Early Aβ accumulation in the mitochondria produces oxidative stress and induces neurodegeneration in APdE9 mice (2017) (0)
- [Aberrant phosphoinositide metabolism in Alzheimer's disease]. (2001) (0)
- Dementia (2017) (0)
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What Schools Are Affiliated With Shun Shimohama?
Shun Shimohama is affiliated with the following schools:
