Siegfried Hekimi
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Swiss Canadian bicycle racer and genetics of aging researcher
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Siegfried Hekimibiology Degrees
Biology
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Genetics
#1546
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#1650
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Biology
Siegfried Hekimi's Degrees
- PhD Genetics University of Geneva
- Masters Biology University of Geneva
- Bachelors Biology University of Geneva
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Why Is Siegfried Hekimi Influential?
(Suggest an Edit or Addition)According to Wikipedia, Siegfried Hekimi is a Swiss former professional racing cyclist and a professor in the Biology Department of McGill University, specializing in the study of aging. He rode in the 1982 Tour de France. After his cycling career, Hekimi obtained a Ph.D. in neurobiology at the University of Geneva.
Siegfried Hekimi's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The genetics of caloric restriction in Caenorhabditis elegans. (1998) (928)
- Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling (2018) (784)
- Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans. (2001) (610)
- A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans (2010) (572)
- Determination of Life-Span in Caenorhabditis elegans by Four Clock Genes (1996) (544)
- Taking a "good" look at free radicals in the aging process. (2011) (524)
- Deletion of the Mitochondrial Superoxide Dismutase sod-2 Extends Lifespan in Caenorhabditis elegans (2009) (486)
- Genetics and the Specificity of the Aging Process (2003) (442)
- Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing. (1995) (411)
- Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice. (2005) (326)
- Structural and Functional Conservation of the Caenorhabditis elegans Timing Gene clk-1 (1997) (308)
- The Intrinsic Apoptosis Pathway Mediates the Pro-Longevity Response to Mitochondrial ROS in C. elegans (2014) (308)
- Superoxide dismutase is dispensable for normal animal lifespan (2012) (305)
- Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging (2015) (272)
- CLK‐1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans (1999) (264)
- When a theory of aging ages badly (2009) (263)
- Meiotic recombination, noncoding DNA and genomic organization in Caenorhabditis elegans. (1995) (261)
- Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans (2010) (219)
- Early Mitochondrial Dysfunction in Long-lived Mclk1+/- Mice* (2008) (202)
- Altered Quinone Biosynthesis in the Long-lived clk-1Mutants of Caenorhabditis elegans * (2001) (198)
- Innexins: a family of invertebrate gap-junction proteins. (1998) (190)
- Mitochondrial dysfunction and longevity in animals: Untangling the knot (2015) (186)
- The unc‐18 Gene Encodes a Novel Protein Affecting the Kinetics of Acetylcholine Metabolism in the Nematode Caenorhabditis elegans (1992) (183)
- A Measurable Increase in Oxidative Damage Due to Reduction in Superoxide Detoxification Fails to Shorten the Life Span of Long-Lived Mitochondrial Mutants of Caenorhabditis elegans (2007) (173)
- Reactive Oxygen Species and Aging in Caenorhabditis elegans: Causal or Casual Relationship? (2010) (167)
- Mitochondrial and Cytoplasmic ROS Have Opposing Effects on Lifespan (2015) (163)
- Understanding Ubiquinone. (2016) (139)
- Ubiquinone Is Necessary for Mouse Embryonic Development but Is Not Essential for Mitochondrial Respiration* (2001) (129)
- Redox Regulation of Germline and Vulval Development in Caenorhabditis elegans (2003) (123)
- Metazoan Scc4 Homologs Link Sister Chromatid Cohesion to Cell and Axon Migration Guidance (2006) (115)
- Elevated Mitochondrial Reactive Oxygen Species Generation Affects the Immune Response via Hypoxia-Inducible Factor-1α in Long-Lived Mclk1+/− Mouse Mutants (2009) (113)
- Basolateral localization of the Caenorhabditis elegans epidermal growth factor receptor in epithelial cells by the PDZ protein LIN-10. (1999) (108)
- FUdR causes a twofold increase in the lifespan of the mitochondrial mutant gas-1 (2011) (103)
- Molecular genetics of life span in C. elegans: how much does it teach us? (1998) (103)
- Decreased Energy Metabolism Extends Life Span in Caenorhabditis elegans Without Reducing Oxidative Damage (2010) (101)
- The UNC-14 protein required for axonal elongation and guidance in Caenorhabditis elegans interacts with the serine/threonine kinase UNC-51. (1997) (98)
- Epithelial cell death is an important contributor to oxidant-mediated acute lung injury. (2011) (92)
- Mitochondrial function and lifespan of mice with controlled ubiquinone biosynthesis (2015) (89)
- Reversal of the Mitochondrial Phenotype and Slow Development of Oxidative Biomarkers of Aging in Long-lived Mclk1+/− Mice* (2009) (89)
- clk-1, mitochondria, and physiological rates. (2000) (84)
- Viable maternal-effect mutations that affect the development of the nematode Caenorhabditis elegans. (1995) (77)
- What keeps C. elegans regular: the genetics of defecation. (2006) (77)
- The C. elegans maternal-effect gene clk-2 is essential for embryonic development, encodes a protein homologous to yeast Tel2p and affects telomere length. (2001) (73)
- The Caenorhabditis elegans Avermectin Resistance and Anesthetic Response Gene unc‐9 Encodes a Member of a Protein Family Implicated in Electrical Coupling of Excitable Cells (1997) (69)
- Ubiquinone Is Necessary for Caenorhabditis elegansDevelopment at Mitochondrial and Non-mitochondrial Sites* (2002) (69)
- The Caenorhabditis elegans Behavioral Gene unc‐24 Encodes a Novel Bipartite Protein Similar to Both Erythrocyte Band 7.2 (Stomatin) and Nonspecific Lipid Transfer Protein (1996) (66)
- Genetics of lifespan in C. elegans: molecular diversity, physiological complexity, mechanistic simplicity. (2001) (65)
- Axonal guidance defects in a Caenorhabditis elegans mutant reveal cell- extrinsic determinants of neuronal morphology (1993) (62)
- Mitochondrial ROS and the Effectors of the Intrinsic Apoptotic Pathway in Aging Cells: The Discerning Killers! (2016) (62)
- CEP-1, the Caenorhabditis elegans p53 Homolog, Mediates Opposing Longevity Outcomes in Mitochondrial Electron Transport Chain Mutants (2014) (59)
- How genetic analysis tests theories of animal aging (2006) (59)
- Antioxidants reveal an inverted U‐shaped dose‐response relationship between reactive oxygen species levels and the rate of aging in Caenorhabditis elegans (2016) (58)
- The levels of the RoRNP-associated Y RNA are dependent upon the presence of ROP-1, the Caenorhabditis elegans Ro60 protein. (1999) (55)
- Molecular genetics of ubiquinone biosynthesis in animals (2013) (55)
- The Molecular Genetics of Aging (2000) (54)
- The Anti-neurodegeneration Drug Clioquinol Inhibits the Aging-associated Protein CLK-1* (2009) (53)
- A Mild Impairment of Mitochondrial Electron Transport Has Sex-Specific Effects on Lifespan and Aging in Mice (2011) (52)
- Pathogenicity of two COQ7 mutations and responses to 2,4‐dihydroxybenzoate bypass treatment (2017) (51)
- Quinones in long‐lived clk‐1 mutants of Caenorhabditis elegans (2002) (48)
- Phenotypic and suppressor analysis of defecation in clk-1 mutants reveals that reaction to changes in temperature is an active process in Caenorhabditis elegans. (2001) (47)
- The submitochondrial distribution of ubiquinone affects respiration in long-lived Mclk1+/− mice (2012) (46)
- Human CLK2 Links Cell Cycle Progression, Apoptosis, and Telomere Length Regulation* (2003) (46)
- Regulation of physiological rates in Caenorhabditis elegans by a tRNA-modifying enzyme in the mitochondria. (2001) (44)
- Biosynthesis of adipokinetic hormones (AKHs): further characterization of precursors and identification of novel products of processing (1989) (42)
- Impact papers on aging in 2009 (2010) (40)
- Identification and purification of two precursors of the insect neuropeptide adipokinetic hormone (1987) (38)
- Targeting protein synthesis in a Myc/mTOR-driven model of anorexia-cachexia syndrome delays its onset and prolongs survival. (2012) (38)
- The Complexity of Making Ubiquinone (2019) (37)
- Mouse CLK-1 Is Imported into Mitochondria by an Unusual Process That Requires a Leader Sequence but No Membrane Potential* (2001) (36)
- Genetic and molecular characterization of CLK-1/mCLK1, a conserved determinant of the rate of aging (2006) (36)
- Thiamine Pyrophosphate Biosynthesis and Transport in the Nematode Caenorhabditis elegans Sequence data from this article have been deposited with the EMBL/GenBank Data Libraries under accession no. AY513235. (2004) (35)
- Sensitivity of Caenorhabditis elegans clk-1 Mutants toUbiquinone Side-chain Length Reveals Multiple Ubiquinone-dependent Processes* (2003) (35)
- ROP-1, an RNA quality-control pathway component, affects Caenorhabditis elegans dauer formation. (2000) (34)
- Mitochondrial respiration without ubiquinone biosynthesis. (2013) (34)
- Why only time will tell (2001) (34)
- Dimer structure of a neuropeptide precursor established: Consequences for processing (1989) (34)
- Regulation of neuropeptide stoichiometry in neurosecretory cells (1991) (33)
- Uncoupling the Pleiotropic Phenotypes of clk-1 with tRNA Missense Suppressors in Caenorhabditis elegans (2006) (31)
- Lipid transport and signaling in Caenorhabditis elegans (2010) (30)
- Different Mechanisms of Longevity in Long-Lived Mouse and Caenorhabditis elegans Mutants Revealed by Statistical Analysis of Mortality Rates (2016) (30)
- Estimating the occurrence of primary ubiquinone deficiency by analysis of large-scale sequencing data (2017) (29)
- mau-2 acts cell-autonomously to guide axonal migrations in Caenorhabditis elegans (2004) (27)
- Molecular Mechanism of Maternal Rescue in the clk-1 Mutants of Caenorhabditis elegans* (2003) (25)
- Many possible maximum lifespan trajectories (2017) (24)
- A single biochemical activity underlies the pleiotropy of the aging-related protein CLK-1 (2017) (22)
- Functional Requirements for Heparan Sulfate Biosynthesis in Morphogenesis and Nervous System Development in C. elegans (2017) (18)
- Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis (2021) (18)
- Cellular and axonal migrations are misguided along both body axes in the maternal-effect mau-2 mutants of Caenorhabditis elegans. (1997) (16)
- SK channel-mediated metabolic escape to glycolysis inhibits ferroptosis and supports stress resistance in C. elegans (2020) (16)
- Lifelong protection from global cerebral ischemia and reperfusion in long-lived Mclk1 +/ − mutants (2010) (16)
- An Enhanced Immune Response of Mclk1 +/− Mutant Mice Is Associated with Partial Protection from Fibrosis, Cancer and the Development of Biomarkers of Aging (2012) (15)
- A microfluidic device for efficient chemical testing using Caenorhabditis elegans (2015) (15)
- Enhanced immunity in slowly aging mutant mice with high mitochondrial oxidative stress (2013) (15)
- Crossroads of aging in the nematode Caenorhabditis elegans. (2000) (15)
- Micellization of coenzyme Q by the fungicide caspofungin allows for safe intravenous administration to reach extreme supraphysiological concentrations (2020) (14)
- A neuron-specific antigen in C. elegans allows visualization of the entire nervous system (1990) (12)
- Antisera against AKHs and AKH precursors for experimental studies of an insect neurosecretory system (1989) (12)
- Impact papers on aging in 2009 - eScholarship (2010) (11)
- Mitochondrial Oxidative Stress Alters a Pathway in Caenorhabditis elegans Strongly Resembling That of Bile Acid Biosynthesis and Secretion in Vertebrates (2012) (11)
- Evolutionary conservation of drug action on lipoprotein metabolism-related targetss⃞ Published, JLR Papers in Press, September 27, 2007. (2008) (9)
- ROS regulation of RAS and vulva development in Caenorhabditis elegans (2020) (9)
- Long-lived mutants, the rate of aging, telomeres and the germline in Caenorhabditis elegans (2002) (9)
- Specification of muscle neurotransmitter sensitivity by a Paired-like homeodomain protein in Caenorhabditis elegans (2005) (9)
- Assessing the function of the Ro ribonucleoprotein complex using Caenorhabditis elegans as a biological tool. (1999) (6)
- The impact of mitochondrial oxidative stress on bile acid-like molecules in C. elegans provides a new perspective on human metabolic diseases (2013) (6)
- Locust Adipokinetic Hormones: Molecular Biology of Biosynthesis (1990) (5)
- A novel COQ7 mutation causing primarily neuromuscular pathology and its treatment options (2022) (5)
- Compensatory elevation of voluntary activity in mouse mutants with impaired mitochondrial energy metabolism (2014) (4)
- Minimal mitochondrial respiration is required to prevent cell death by inhibition of mTOR signaling in CoQ-deficient cells (2021) (4)
- The age of heterozygosity (2006) (4)
- Proteostasis or Aging: Let the CHIPs Fall Where They May. (2017) (3)
- The submitochondrial distribution of ubiquinone affects respiration in long-lived Mclk1+/2 mice (2012) (3)
- The efficacy of coenzyme Q10 treatment in alleviating the symptoms of primary coenzyme Q10 deficiency: A systematic review (2022) (3)
- Faculty Opinions recommendation of On the Origin of Superoxide Dismutase: An Evolutionary Perspective of Superoxide-Mediated Redox Signaling. (2020) (3)
- Neurohormones in Invertebrates: Functions of aminergic and peptidergic skeletal motoneurones in insects (1988) (3)
- Mitochondrial dysfunction, aging, and the mitochondrial unfolded protein response in Caenorhabditis elegans. (2022) (2)
- Elevated Mitochondrial Reactive Oxygen (2009) (2)
- Novel Homozygous Variant in COQ7 in Siblings With Hereditary Motor Neuropathy (2023) (1)
- Stimulation of RAS-dependent ROS signaling extends longevity by modulating a developmental program of global gene expression (2022) (1)
- Mclk1+/- mice are not resistant to the development of atherosclerosis (2009) (1)
- Phylogenetic ubiquity of the effects of altered ubiquinone biosynthesis on survival (2011) (1)
- Faculty Opinions recommendation of Translation readthrough mitigation. (2018) (0)
- Faculty of 1000 evaluation for Balancing reactive oxygen species in the epigenome: NADPH oxidases as target and perpetrator. (2017) (0)
- Mouse Mutants - +/ Mclk1 Long-Lived in a Response via Hypoxia-Inducible Factor-1 Species Generation Affects the Immune Elevated Mitochondrial Reactive Oxygen (2009) (0)
- A Microfluidic Device for Caenorhabditis Elegans Based Chemical Testing (2014) (0)
- Faculty Opinions recommendation of Oxidative stress is not a major contributor to somatic mitochondrial DNA mutations. (2015) (0)
- Making a splash with splicing (2017) (0)
- Making a splash with splicing (2017) (0)
- Faculty Opinions recommendation of Lifespan Control by Redox-Dependent Recruitment of Chaperones to Misfolded Proteins. (2018) (0)
- Efficacy of CoQ10 supplementation for the treatment of primary CoQ10 deficiency (2022) (0)
- Faculty of 1000 evaluation for Mitochondrial quality control: a matter of life and death for neurons. (2013) (0)
- Faculty Opinions recommendation of Prostaglandin signals from adult germ stem cells delay somatic aging of Caenorhabditis elegans. (2021) (0)
- A possible link between posttranslational processing of ROP-1 and cleavage of the RoRNP-associated Y RNA during Caenorhabditis elegans larval development (1999) (0)
- Minimal mitochondrial respiration is required to prevent cell death by inhibition of mTOR signaling in CoQ-deficient cells (2021) (0)
- Faculty Opinions recommendation of The hoverfly and the wasp: A critique of the hallmarks of aging as a paradigm. (2022) (0)
- Faculty Opinions recommendation of Using MRI to measure in vivo free radical production and perfusion dynamics in a mouse model of elevated oxidative stress and neurogenic atrophy. (2019) (0)
- Faculty Opinions recommendation of Postnatal Exocrine Pancreas Growth by Cellular Hypertrophy Correlates with a Shorter Lifespan in Mammals. (2019) (0)
- Faculty Opinions recommendation of A polarized Ca2+, diacylglycerol and STIM1 signalling system regulates directed cell migration. (2018) (0)
- A single biochemical activity underlies the pleiotropy of the aging-related protein CLK-1 (2017) (0)
- Faculty Opinions recommendation of Mitochondrial Dysfunction Combined with High Calcium Load Leads to Impaired Antioxidant Defense Underlying the Selective Loss of Nigral Dopaminergic Neurons. (2020) (0)
- Faculty Opinions recommendation of Social stress shortens lifespan in mice. (2018) (0)
- Mitochondrial ROS signaling moderates the rate of aging (2011) (0)
- Faculty Opinions recommendation of Lifespan of neurons is uncoupled from organismal lifespan. (2013) (0)
- Faculty Opinions recommendation of Coenzyme Q biosynthetic proteins assemble in a substrate-dependent manner into domains at ER-mitochondria contacts. (2019) (0)
- Estimating the occurrence of primary ubiquinone deficiency by analysis of large-scale sequencing data (2017) (0)
- A microfluidic device for efficient chemical testing using Caenorhabditis elegans (2015) (0)
- Faculty Opinions recommendation of A soluble metabolon synthesizes the isoprenoid lipid ubiquinone. (2019) (0)
- Faculty Opinions recommendation of Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide. (2013) (0)
- Th-P17:421 An in vivo invertebrate platform for identifying new pharmacological agents that modulate lipoprotein metabolism (2006) (0)
- Faculty Opinions recommendation of The O-GlcNAc transferase OGT is a conserved and essential regulator of the cellular and organismal response to hypertonic stress. (0)
- The CoQ biosynthetic di-iron carboxylate hydroxylase COQ7 is inhibited by in vivo metalation with manganese but remains functional by metalation with cobalt (2022) (0)
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What Schools Are Affiliated With Siegfried Hekimi?
Siegfried Hekimi is affiliated with the following schools:
