Sigurd Lenzen
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(Suggest an Edit or Addition)Sigurd Lenzen's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The mechanisms of alloxan- and streptozotocin-induced diabetes (2008) (1943)
- Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities. (2005) (1420)
- Relation Between Antioxidant Enzyme Gene Expression and Antioxidative Defense Status of Insulin-Producing Cells (1997) (1209)
- Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues. (1996) (1141)
- Oxidative stress: the vulnerable beta-cell. (2008) (459)
- Relative importance of transport and alkylation for pancreatic beta-cell toxicity of streptozotocin (2000) (375)
- Alloxan: history and mechanism of action (1988) (227)
- Protection of insulin-producing RINm5F cells against cytokine-mediated toxicity through overexpression of antioxidant enzymes. (2000) (210)
- Complementary action of antioxidant enzymes in the protection of bioengineered insulin-producing RINm5F cells against the toxicity of reactive oxygen species. (1998) (202)
- Peroxisome-Generated Hydrogen Peroxide as Important Mediator of Lipotoxicity in Insulin-Producing Cells (2010) (193)
- Improvement of the mitochondrial antioxidant defense status prevents cytokine-induced nuclear factor-kappaB activation in insulin-producing cells. (2003) (175)
- Control of insulin secretion by sulfonylureas, meglitinide and diazoxide in relation to their binding to the sulfonylurea receptor in pancreatic islets. (1989) (173)
- Role of metabolically generated reactive oxygen species for lipotoxicity in pancreatic β‐cells (2010) (158)
- Thyroid hormones, gonadal and adrenocortical steroids and the function of the islets of Langerhans. (1984) (155)
- Mitochondrial catalase overexpression protects insulin-producing cells against toxicity of reactive oxygen species and proinflammatory cytokines. (2004) (145)
- Thiol-group reactivity, hydrophilicity and stability of alloxan, its reduction products and its N-methyl derivatives and a comparison with ninhydrin. (1991) (120)
- Importance of the GLUT2 glucose transporter for pancreatic beta cell toxicity of alloxan (2002) (118)
- Immune cell infiltration, cytokine expression, and beta-cell apoptosis during the development of type 1 diabetes in the spontaneously diabetic LEW.1AR1/Ztm-iddm rat. (2005) (115)
- Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes (2017) (114)
- A Fresh View of Glycolysis and Glucokinase Regulation: History and Current Status* (2014) (112)
- Sustained production of spliced X-box binding protein 1 (XBP1) induces pancreatic beta cell dysfunction and apoptosis (2010) (112)
- Comparative toxicity of alloxan, N-alkylalloxans and ninhydrin to isolated pancreatic islets in vitro. (1997) (111)
- Protection against the co-operative toxicity of nitric oxide and oxygen free radicals by overexpression of antioxidant enzymes in bioengineered insulin-producing RINm5F cells (1999) (110)
- The LEW.1AR1/Ztm-iddm rat: a new model of spontaneous insulin-dependent diabetes mellitus (2001) (105)
- Interaction of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2) with glucokinase activates glucose phosphorylation and glucose metabolism in insulin-producing cells. (2004) (96)
- Interaction between pro-inflammatory and anti-inflammatory cytokines in insulin-producing cells. (2008) (87)
- Characterization of Glucokinase-binding Protein Epitopes by a Phage-displayed Peptide Library (2001) (85)
- Chemistry and biology of reactive species with special reference to the antioxidative defence status in pancreatic β-cells. (2017) (83)
- Cytotoxicity and activation of the Wnt/beta-catenin pathway in mouse embryonic stem cells treated with four GSK3 inhibitors (2014) (83)
- MIN6 β-cell-β-cell interactions influence insulin secretory responses to nutrients and non-nutrients (2006) (82)
- Importance of cysteine residues for the stability and catalytic activity of human pancreatic beta cell glucokinase. (2000) (81)
- Frontiers of insulin secretion and pancreatic B-cell research (1994) (81)
- Insulin secretion by isolated perfused rat and mouse pancreas. (1979) (78)
- Islet infiltration, cytokine expression and beta cell death in the NOD mouse, BB rat, Komeda rat, LEW.1AR1-iddm rat and humans with type 1 diabetes (2014) (76)
- Concentration-dependent effects of tolbutamide, meglitinide, glipizide, glibenclamide and diazoxide on ATP-regulated K+ currents in pancreatic B-cells (1988) (70)
- Alloxan derivatives as a tool for the elucidation of the mechanism of the diabetogenic action of alloxan (1996) (67)
- Interactions between spermine and Mg2+ on mitochondrial Ca2+ transport. (1986) (67)
- Effect of superoxide dismutase, catalase, chelating agents, and free radical scavengers on the toxicity of alloxan to isolated pancreatic islets in vitro. (1999) (67)
- Signal recognition by pancreatic B-cells. (1988) (66)
- Antagonism Between Saturated and Unsaturated Fatty Acids in ROS Mediated Lipotoxicity in Rat Insulin-Producing Cells (2015) (63)
- Cytokine toxicity in insulin-producing cells is mediated by nitro-oxidative stress-induced hydroxyl radical formation in mitochondria (2011) (62)
- Glucokinase in pancreatic B-cells and its inhibition by alloxan. (1987) (61)
- Cytokines and nitric oxide inhibit the enzyme activity of catalase but not its protein or mRNA expression in insulin-producing cells. (2003) (61)
- Modulation of Bcl-2-related protein expression in pancreatic beta cells by pro-inflammatory cytokines and its dependence on the antioxidative defense status (2011) (58)
- Relative importance of cellular uptake and reactive oxygen species for the toxicity of alloxan and dialuric acid to insulin-producing cells. (2006) (57)
- Regulation of insulin secretion by energy metabolism in pancreatic B-cell mitochondria. Studies with a non-metabolizable leucine analogue. (1984) (55)
- Metabolic regulation, activity state, and intracellular binding of glucokinase in insulin-secreting cells. (1999) (53)
- The role of lipid droplet formation in the protection of unsaturated fatty acids against palmitic acid induced lipotoxicity to rat insulin-producing cells (2016) (53)
- Importance of mitochondrial superoxide dismutase expression in insulin-producing cells for the toxicity of reactive oxygen species and proinflammatory cytokines (2005) (52)
- Peroxiredoxin 4 Improves Insulin Biosynthesis and Glucose-induced Insulin Secretion in Insulin-secreting INS-1E Cells* (2014) (51)
- Fatty acid-induced toxicity and neutral lipid accumulation in insulin-producing RINm5F cells. (2006) (51)
- Impaired Glucose-Stimulated Insulin Secretion Is Coupled With Exocrine Pancreatic Lesions in the Cohen Diabetic Rat (2008) (51)
- The Generation of Definitive Endoderm from Human Embryonic Stem Cells is Initially Independent from Activin A but Requires Canonical Wnt-Signaling (2014) (51)
- ERO1-independent production of H2O2 within the endoplasmic reticulum fuels Prdx4-mediated oxidative protein folding (2015) (50)
- Lipid composition of glucose-stimulated pancreatic islets and insulin-secreting tumor cells (1994) (50)
- The H2O2-sensitive HyPer protein targeted to the endoplasmic reticulum as a mirror of the oxidizing thiol-disulfide milieu. (2012) (48)
- Transamination of neutral amino acids and 2-keto acids in pancreatic B-cell mitochondria. (1985) (48)
- Reversal of diabetes through gene therapy of diabetic rats by hepatic insulin expression via lentiviral transduction. (2012) (48)
- Differential effects of proinflammatory cytokines on cell death and ER stress in insulin-secreting INS1E cells and the involvement of nitric oxide. (2011) (47)
- Interaction of glucokinase with the liver regulatory protein is conferred by leucine-asparagine motifs of the enzyme. (2005) (47)
- Insulin-producing surrogate β-cells from embryonic stem cells: are we there yet? (2011) (46)
- Diabetes prevention by immunomodulatory FTY720 treatment in the LEW.1AR1-iddm rat despite immune cell activation. (2010) (46)
- MIN6 beta-cell-beta-cell interactions influence insulin secretory responses to nutrients and non-nutrients. (2006) (45)
- Inhibition of glucokinase by alloxan through interaction with SH groups in the sugar-binding site of the enzyme. (1988) (44)
- Sensitivity profile of the human EndoC-βH1 beta cell line to proinflammatory cytokines (2016) (44)
- Signal function of metabolism of neutral amino acids and 2-keto acids for initiation of insulin secretion. (1982) (43)
- Thyroid function and insulin secretion from the perfused pancreas in the rat. (1976) (42)
- 3-Ketoglutarate generation in pancreatic B-cell mitochondria regulates insulin secretory action of amino acids and 2-keto acids (1986) (42)
- Dose-response studies on the inhibitory effect of thyroid hormones on insulin secretion in the rat. (1978) (41)
- Polyamine modulation of mitochondrial calcium transport. I. Stimulatory and inhibitory effects of aliphatic polyamines, aminoglucosides and other polyamine analogues on mitochondrial calcium uptake. (1998) (41)
- Importance of lactate dehydrogenase for the regulation of glycolytic flux and insulin secretion in insulin-producing cells. (2000) (40)
- ER-resident antioxidative GPx7 and GPx8 enzyme isoforms protect insulin-secreting INS-1E β-cells against lipotoxicity by improving the ER antioxidative capacity. (2017) (40)
- Glucose both inhibits and stimulates insulin secretion from isolated pancreatic islets exposed to maximally effective concentrations of sulfonylureas (1988) (40)
- Progesterone induces apoptosis of insulin-secreting cells: insights into the molecular mechanism. (2014) (39)
- Prevention of insulin resistance and beta‐cell loss by abrogating PKCε‐induced serine phosphorylation of muscle IRS‐1 in Psammomys obesus (2008) (39)
- Regulation of glucokinase and GLUT-2 glucose-transporter gene expression in pancreatic B-cells. (1991) (39)
- Mechanism underlying resistance of human pancreatic beta cells against toxicity of streptozotocin and alloxan (2003) (38)
- Structural requirements of alloxan and ninhydrin for glucokinase inhibition and of glucose for protection against inhibition (1988) (38)
- Insulin secretion, insulin content and glucose phosphorylation in RINm5F insulinoma cells after transfection with human GLUT2 glucose-transporter cDNA. (1993) (38)
- Physiological characterization of the human EndoC-βH1 β-cell line. (2015) (36)
- Effects of metformin on SGLT1, GLUT2, and GLUT5 hexose transporter gene expression in small intestine from rats (1996) (35)
- Thyroxine induces pancreatic beta-cell apoptosis in rats (2002) (35)
- Dual effect of spermine on mitochondrial Ca2+ transport. (1992) (34)
- Modulation of human glucokinase intrinsic activity by SH reagents mirrors post-translational regulation of enzyme activity. (1997) (34)
- Susceptibility of brown adipocytes to pro-inflammatory cytokine toxicity and reactive oxygen species (2016) (34)
- Selective Removal of Undifferentiated Embryonic Stem Cells from Differentiation Cultures Through HSV1 Thymidine Kinase and Ganciclovir Treatment (2010) (34)
- Differential regulation of [Ca2+]i oscillations in mouse pancreatic islets by glucose, alpha-ketoisocaproic acid, glyceraldehyde and glycolytic intermediates. (2000) (34)
- Overexpression of the antioxidant enzyme catalase does not interfere with the glucose responsiveness of insulin-secreting INS-1E cells and rat islets (2013) (34)
- The central role of glutathione peroxidase 4 in the regulation of ferroptosis and its implications for pro-inflammatory cytokine-mediated beta-cell death. (2021) (34)
- Regulation of energy metabolism in pancreatic islets by glucose and tolbutamide (1986) (34)
- Induction of the intrinsic apoptosis pathway in insulin-secreting cells is dependent on oxidative damage of mitochondria but independent of caspase-12 activation. (2011) (33)
- Triiodothyronine (T3)-mediated toxicity and induction of apoptosis in insulin-producing INS-1 cells. (2007) (33)
- Engineering of a glucose-responsive surrogate cell for insulin replacement therapy of experimental insulin-dependent diabetes. (2000) (33)
- Effects of glucose refeeding and glibenclamide treatment on glucokinase and GLUT2 gene expression in pancreatic B-cells and liver from rats. (1995) (33)
- Polyamine modulation of mitochondrial calcium transport. II. Inhibition of mitochondrial permeability transition by aliphatic polyamines but not by aminoglucosides. (1998) (31)
- Pathology of the pancreas and other organs in the diabetic LEW.1AR1/Ztm-iddm rat, a new model of spontaneous insulin-dependent diabetes mellitus (2004) (31)
- TriPer, an optical probe tuned to the endoplasmic reticulum tracks changes in luminal H2O2 (2017) (31)
- The monounsaturated fatty acid oleate is the major physiological toxic free fatty acid for human beta cells (2017) (31)
- The relationship between the physicochemical properties and the biological effects of alloxan and several N-alkyl substituted alloxan derivatives. (1993) (30)
- Endogenous activation of glucokinase by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase is glucose dependent. (2010) (30)
- Identification of the Ubiquitin-like Domain of Midnolin as a New Glucokinase Interaction Partner* (2013) (30)
- Improved metabolic stimulus for glucose-induced insulin secretion through GK and PFK-2/FBPase-2 coexpression in insulin-producing RINm5F cells. (2006) (30)
- Insulin secretion and the morphological and metabolic characteristics of pancreatic islets of hyperthyroid ob/ob mice. (1978) (29)
- 2-oxocarboxylic acids and function of pancreatic islets in obese-hyperglycaemic mice. Insulin secretion in relation to 45Ca uptake and metabolism. (1980) (29)
- Real-time analysis of intracellular glucose and calcium in pancreatic beta cells by fluorescence microscopy. (2012) (29)
- Effects of IP3, Spermine, and Mg2+ on Regulation of Ca2+ Transport by Endoplasmic Reticulum and Mitochondria in Permeabilized Pancreatic Islets (1991) (28)
- Structure-toxicity relationships of saturated and unsaturated free fatty acids for elucidating the lipotoxic effects in human EndoC-βH1 beta-cells. (2019) (28)
- Beta cell death in hyperglycaemic Psammomys obesus is not cytokine-mediated (2006) (27)
- Protection of insulin-producing cells against toxicity of dexamethasone by catalase overexpression. (2009) (26)
- The ubiquitin-proteasome system regulates the stability and activity of the glucose sensor glucokinase in pancreatic β-cells. (2013) (26)
- Regulation of transmembrane ion transport by reaction products of phospholipase A2. II. Effects of arachidonic acid and other fatty acids on mitochondrial Ca2+ transport. (1989) (25)
- 40th EASD Annual Meeting of the European Association for the Study of Diabetes (2004) (25)
- Nutrient-dependent distribution of insulin and glucokinase immunoreactivities in rat pancreatic beta cells (1999) (24)
- Recovery of Pancreatic &bgr; Cells in Response to Long-term Normoglycemia After Pancreas or Islet Transplantation in Severely Streptozotocin Diabetic Adult Rats (2001) (24)
- Loss of GLUT2 glucose transporter expression in pancreatic beta cells from diabetic Chinese hamsters (1996) (24)
- A Critical Re-Evaluation of CD24-Positivity of Human Embryonic Stem Cells Differentiated into Pancreatic Progenitors (2012) (24)
- miRNome Profiling of Purified Endoderm and Mesoderm Differentiated from hESCs Reveals Functions of miR-483-3p and miR-1263 for Cell-Fate Decisions (2017) (23)
- Regulation of transmembrane ion transport by reaction products of phospholipase A2. I. Effects of lysophospholipids on mitochondrial Ca2+ transport. (1989) (23)
- Changes in gene expression and morphology of mouse embryonic stem cells on differentiation into insulin‐producing cells in vitro and in vivo (2009) (23)
- Overexpression of sphingosine-1-phosphate lyase protects insulin-secreting cells against cytokine toxicity (2017) (23)
- Results, meta-analysis and a first evaluation of UNOxR, the urinary nitrate-to-nitrite molar ratio, as a measure of nitrite reabsorption in experimental and clinical settings (2018) (22)
- Prevention of spontaneous immune-mediated diabetes development in the LEW.1AR1-iddm rat by selective CD8+ T cell transfer is associated with a cytokine shift in the pancreas-draining lymph nodes (2009) (22)
- Animal models of human type 1 diabetes for evaluating combination therapies and successful translation to the patient with type 1 diabetes (2017) (22)
- Relation between accumulation of phospholipase A2 reaction products and Ca2+ release in isolated liver mitochondria. (1996) (22)
- β-Cell DNA Damage Response Promotes Islet Inflammation in Type 1 Diabetes (2018) (22)
- Dietary copper supplementation restores β-cell function of Cohen diabetic rats: a link between mitochondrial function and glucose-stimulated insulin secretion. (2013) (22)
- Relation between triketone structure, generation of reactive oxygen species, and selective toxicity of the diabetogenic agent alloxan. (2008) (21)
- Protection against Cytokine Toxicity through Endoplasmic Reticulum and Mitochondrial Stress Prevention by Prostacyclin Synthase Overexpression in Insulin-producing Cells* (2010) (21)
- Genetic analysis of the LEW.1AR1-iddm rat: an animal model for spontaneous diabetes mellitus (2005) (21)
- Sequencing of candidate genes selected by beta cell experts in monogenic diabetes of unknown aetiology. (2010) (21)
- TNF-α Antibody Therapy in Combination With the T-Cell–Specific Antibody Anti-TCR Reverses the Diabetic Metabolic State in the LEW.1AR1-iddm Rat (2015) (20)
- A New Experimental Protocol for Preferential Differentiation of Mouse Embryonic Stem Cells into Insulin-Producing Cells (2008) (20)
- Increased Hsp70 expression attenuates cytokine-induced cell death in islets of Langerhans from Shb knockout mice. (2009) (20)
- Cytokines activate genes of the endocytotic pathway in insulin-producing RINm5F cells (2004) (20)
- Defective regulation of glucokinase in rat pancreatic islet cell tumours. (1987) (19)
- Characterization of succinate dehydrogenase and alpha-glycerophosphate dehydrogenase in pancreatic islets. (1983) (19)
- Molecular characterization of the glucose-sensing mechanism in the clonal insulin-secreting BRIN-BD11 cell line. (1998) (19)
- An efficient experimental strategy for mouse embryonic stem cell differentiation and separation of a cytokeratin‐19‐positive population of insulin‐producing cells (2008) (19)
- Further studies on the relationship between insulin release and lanthanum-nondisplaceable 45Ca2+ uptake by pancreatic islets: effects of fructose and starvation. (1978) (19)
- Effects of α-ketocarboxylic acids and 4-pentenoic acid on insulin secretion from the perfused rat pancreas (1978) (18)
- Thyroxine treatment and insulin secretion in the rat (2004) (18)
- Effect of lysophospholipids, arachidonic acid and other fatty acids on regulation of Ca2+ transport in permeabilized pancreatic islets. (1992) (18)
- Anti-TCR therapy combined with fingolimod for reversal of diabetic hyperglycemia by β cell regeneration in the LEW.1AR1-iddm rat model of type 1 diabetes (2014) (18)
- Additive activation of glucokinase by the bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase and the chemical activator LY2121260. (2012) (18)
- Mechanism of prostacyclin-induced potentiation of glucose-induced insulin secretion. (2012) (18)
- Effect of metformin on SGLT1, GLUT2, and GLUT5 hexose transporter gene expression in small intestine from rats. (1996) (18)
- Gradual loss of pancreatic beta-cell insulin, glucokinase and GLUT2 glucose transporter immunoreactivities during the time course of nutritionally induced type-2 diabetes in Psammomys obesus (sand rat) (2014) (17)
- A Variable CD3+ T-Cell Frequency in Peripheral Blood Lymphocytes Associated with Type 1 Diabetes Mellitus Development in the LEW.1AR1-iddm Rat (2013) (16)
- Dynamics of Insulin Secretion from EndoC-βH1 β-Cell Pseudoislets in Response to Glucose and Other Nutrient and Nonnutrient Secretagogues (2017) (16)
- Quantitation of hexadecylphosphocholine by high-performance thin-layer chromatography with densitometry. (1990) (16)
- Inhibition of insulin secretion by L-thyroxine and D-thyroxine treatment in rats under the influence of drugs affecting the adrenergic nervous system. (1982) (16)
- Effects of various modifiers of insulin release on the lanthanum-nondisplaceable45ca2+ uptake by isolated pancreatic islets (2004) (16)
- Immune cell and cytokine patterns in children with type 1 diabetes mellitus undergoing a remission phase: A longitudinal study (2018) (16)
- Pancreas Pathology of Latent Autoimmune Diabetes in Adults (LADA) in Patients and in a LADA Rat Model Compared With Type 1 Diabetes (2020) (16)
- Kinetics of insulin secretion from MIN6 pseudoislets after encapsulation in a prototype device of a bioartificial pancreas. (2009) (16)
- A versatile Ca2+ ion-sensitive minielectrode with a microincubation chamber. (1985) (16)
- The Immediate Insulin-secretory Response of the Rat Pancreas to Glucose Compared with Tolbutamide and Other Secretagogues (1978) (16)
- Effects of tolbutamide and N-benzoyl-D-phenylalanine (NBDP) on the regulation of [Ca2+]i oscillations in mouse pancreatic islets. (2001) (15)
- INHIBITION OF GLUCOKINASE AND HEXOKINASE FROM PANCREATIC B-CELLS AND LIVER BY ALLOXAN, ALLOXANTIN, DIALURIC ACID, AND t-BUTYLHYDROPEROXIDE (1991) (15)
- Glucose-induced dissociation of glucokinase from its regulatory protein in the nucleus of hepatocytes prior to nuclear export. (2014) (15)
- Novel Insights Into the Regulation of the Bound and Diffusible Glucokinase in MIN6 β-Cells (2007) (15)
- Transamination of 3-phenylpyruvate in pancreatic B-cell mitochondria. (1984) (15)
- Effect of spermine on mitochondrial matrix calcium in relation to its enhancement of mitochondrial calcium uptake. (1993) (15)
- The mutation of the LEW.1AR1-iddm rat maps to the telomeric end of rat chromosome 1 (2008) (14)
- Enhancement of homocysteine toxicity to insulin-secreting BRIN-BD11 cells in combination with alloxan. (2012) (14)
- Beta Cell Mass Regulation in the Rat Pancreas Through Glucocorticoids and Thyroid Hormones (2010) (13)
- Monitoring of glucose-regulated single insulin secretory granule movement by selective photoactivation (2008) (13)
- Effects of polyinosinic-polycytidylic acid and adoptive transfer of immune cells in the LEW.1AR1-iddm rat and in its coisogenic LEW.1AR1 background strain (2005) (13)
- Glucokinase mediates coupling of glycolysis to mitochondrial metabolism but not to beta cell damage at high glucose exposure levels (2011) (13)
- Effects of pyruvate, L-lactate, and 3-phenylpyruvate on function of ob/ob mouse pancreatic islets: insulin secretion in relation to 45Ca2+ uptake and metabolism. (1981) (13)
- Alloxan and ninhydrin inhibition of hexokinase from pancreatic islets and tumoural insulin-secreting cells. (1990) (13)
- The effect of hydrocortisone treatment and adrenalectomy on insulin and glucagon secretion from the perfused rat pancreas. (1976) (13)
- Intracellular localization of calcium in pancreatic B-cells in relation to insulin secretion by the perfused ob/ob mouse pancreas. (1984) (12)
- Beta cell DNA damage response promotes islet inflammation in type 1 diabetes (2018) (12)
- Structural requirements of lysophospholipid-regulated mitochondrial Ca2+ transport. (1991) (12)
- Regulation of pancreatic B-cell glucokinase and GLUT2 glucose transporter gene expression. (1994) (12)
- MCPIP1 regulates the sensitivity of pancreatic beta-cells to cytokine toxicity (2019) (12)
- Influence of cytokines on Dmt1 iron transporter and ferritin expression in insulin-secreting cells. (2014) (12)
- Differential regulation of glucokinase and GLUT-2 glucose transporter gene expression in pancreas and liver from neonatal and 16 day old rats. (1993) (12)
- Antidiabetic Effect of Interleukin-1β Antibody Therapy Through β-Cell Protection in the Cohen Diabetes-Sensitive Rat (2014) (12)
- Impact of scavenging hydrogen peroxide in the endoplasmic reticulum for β cell function. (2015) (11)
- Effects of sodium butyrate on glucose transporter and glucose-phosphorylating enzyme gene expression in RINm5F insulinoma cells. (1996) (11)
- N-glycosylation-negative catalase: a useful tool for exploring the role of hydrogen peroxide in the endoplasmic reticulum. (2015) (11)
- Hydrogen peroxide permeability of cellular membranes in insulin-producing cells. (2020) (11)
- Toxicity of fatty acid profiles of popular edible oils in human EndoC-βH1 beta-cells (2020) (11)
- Effects of the novel mitochondrial protein mimitin in insulin-secreting cells. (2012) (11)
- Diabetes therapy by lentiviral hepatic insulin gene expression without transformation of liver (2008) (11)
- Regulation of [Ca2+]i oscillations in mouse pancreatic islets by adrenergic agonists. (2007) (11)
- Is there a role for neuronal nitric oxide synthase (nNOS) in cytokine toxicity to pancreatic beta cells? (2012) (11)
- 35th Annual meeting of the European Association for the Study of Diabetes. Brussels, Belgium, 28 September-2 October, 1999. Abstracts. (1999) (11)
- A reliable and efficient protocol for human pluripotent stem cell differentiation into the definitive endoderm based on dispersed single cells. (2015) (11)
- Remission of autoimmune diabetes by anti-TCR combination therapies with anti-IL-17A or/and anti-IL-6 in the IDDM rat model of type 1 diabetes (2020) (10)
- Inhibition of aconitase by alloxan and the differential modes of protection of glucose, 3-O-methylglucose, and mannoheptulose (1992) (10)
- Effects of ovariectomy and treatment with progesterone or oestradiol-17 beta on the secretion of insulin by the perfused rat pancreas. (1978) (10)
- Inhibition of insulin and glucagon release from the perfused rat pancreas by cyproheptadine (Periactinol®, Nuran®) (1976) (9)
- A novel Dock8 gene mutation confers diabetogenic susceptibility in the LEW.1AR1/Ztm-iddm rat, an animal model of human type 1 diabetes (2015) (9)
- A versatile microfiltration device. (1983) (9)
- Effect of substrate rigidity in tissue culture on the function of insulin‐secreting INS‐1E cells (2017) (9)
- Light-induced intracellular hydrogen peroxide generation through genetically encoded photosensitizer KillerRed-SOD1 (2018) (9)
- MicroRNA Target Sites as Genetic Tools to Enhance Promoter-Reporter Specificity for the Purification of Pancreatic Progenitor Cells from Differentiated Embryonic Stem Cells (2013) (9)
- Monoamine oxidase in pancreatic islets, exocrine pancreas, and liver from rats. Characterization with clorgyline, deprenyl, pargyline, tranylcypromine, and amezinium (1983) (9)
- N-Arylsulfonyl-benzimidazolones as Potential Hypoglycemic Agents (2002) (8)
- Inhibition o'f insulin release by cyproheptadine: effects on 3',5'-cyclic-AMP-content and 45Ca-accumulation of incubated mouse islets. (1976) (8)
- The immediate insulin secretory response of the isolated perfused rat pancreas to tolbutamide and glucose (1975) (8)
- Effects of isoprenaline and glucagon on insulin secretion from pancreatic islets (1985) (8)
- Prevention of nutritionally induced diabetes by rosiglitazone in the gerbil Psammomys obesus (2006) (8)
- Novel insights into the regulation of the bound and diffusible glucokinase in MIN6 beta-cells. (2007) (8)
- Glibenclamide induces glucokinase in rat pancreatic islets and liver. (1986) (8)
- Differential effects of saturated and unsaturated free fatty acids on ferroptosis in rat β-cells. (2022) (7)
- The dihydropyridine derivative, Bay K 8644, enhances insulin secretion by isolated pancreatic islets (2004) (7)
- Effects of alloxan and ninhydrin on mitochondrial Ca2+ transport (1992) (7)
- Variable immune cell frequencies in peripheral blood of LEW.1AR1‐iddm rats over time compared to other congenic LEW strains (2014) (7)
- The pro-radical hydrogen peroxide as a stable hydroxyl radical distributor: lessons from pancreatic beta cells (2022) (6)
- Quantification of cells in islets of langerhans using DNA determination (2005) (6)
- Dimer interface rearrangement of the 6‐phosphofructo‐2‐kinase/fructose 2,6‐bisphosphatase rat liver isoenzyme by cAMP‐dependent Ser‐32 phosphorylation (2012) (6)
- Dissociation between effects of polyamines on mitochondrial calcium uptake and mitochondrial permeability transition by elongation of polyamine methylene backbone. (1996) (6)
- Pancreatic B-cell FAD-glycerophosphate dehydrogenase deficiency in non-insulin-dependent diabetes: an up-dated review (1994) (6)
- Rat Models of Human Type 1 Diabetes. (2020) (5)
- Role of Sulfhydril Groups in GK Catalysis for GK Function (2004) (5)
- Effects of lysophosphatidylcholine and arachidonic acid on the regulation of intracellular Ca2+ transport (2004) (5)
- Streptozotocin: Fundamentals and therapy edited by M.K. Agarwal, Elsevier/ North-Holland, Amsterdam, 1981, viii + 310 pp. US $ 95.00; Dfl. 195.00. ISBN 0-444-80302-5 (1981) (5)
- The pancreatic beta cell: an intricate relation between anatomical structure, the signalling mechanism of glucose-induced insulin secretion, the low antioxidative defence, the high vulnerability and sensitivity to diabetic stress (2021) (5)
- [Pluripotent stem cells for cell replacement therapy of diabetes]. (2012) (5)
- Changes of function and metabolism of the pancreatic B-cell caused by amino acids and related compounds. (1980) (5)
- Improved antioxidative defence protects insulin-producing cells against homocysteine toxicity. (2016) (4)
- Hexose recognition mechanisms in pancreatic B-cells. (1990) (3)
- Effects of alpha-ketocarboxylic acids and 4-pentenoic acid on insulin secretion from the perfused rat pancreas. (1978) (3)
- The inhibition of insulin secretion from the perfused rat pancreas after thyroxine treatment (1976) (3)
- Secretory, enzymatic, and morphological characterization of rat pancreatic endocrine tumours induced by streptozotocin and nicotinamide. (1985) (3)
- The importance of aquaporin-8 for cytokine-mediated toxicity in rat insulin-producing cells. (2021) (3)
- 35th Annual Meeting of the European Association for the Study of Diabetes (2016) (3)
- Inhibition of glucokinase in pancreatic B-cells by alloxan (1987) (3)
- The effect of thyroxine treatment on the dynamics of insulin release from the isolated perfused rat pancreas (2004) (3)
- Possible relationship between the B-cell threshold for glucose-induced insulin secretion and blood glucose concentrations in the normal toad. (2000) (3)
- Combination of biotransformation and chromatography for the isolation and purification of mannoheptulose (2007) (2)
- Is Nitric Oxide Really the Primary Mediator of Pancreatic β-Cell Death in Type 1 Diabetes? (2015) (2)
- Gene therapy of diabetes mellitus--aims, methods and future prospects. (2009) (2)
- Branched Chain Amino and Keto Acids — Tools for the Investigation of Fuel Recognition Mechanism in Pancreatic B-Cells1 (1984) (2)
- Calcium ultracytochemistry in pancreatic B-cells. (1980) (2)
- Degradation of dansyl polyamines on high-performance thin-layer chromatographic plates. (1995) (2)
- Asymmetric dimethylation and citrullination in the LEW.1AR1-iddm rat, an animal model of human type 1 diabetes, and effects of anti-TCR/anti-TNF-α antibody-based therapy (2019) (2)
- Proceedings: Studies on the inhibitory effect of thyroxine on insulin secretion from the perfused rat pancreas. (1975) (1)
- Results, meta-analysis and a first evaluation of UNOxR, the urinary nitrate-to-nitrite molar ratio, as a measure of nitrite reabsorption in experimental and clinical settings (2018) (1)
- A new rat model for insulin-dependent diabetes mellitus (Iddm) (2000) (1)
- Advanced Glycation End-Products (AGEs) of Lysine and Effects of Anti-TCR/Anti-TNF-α Antibody-Based Therapy in the LEW.1AR1-iddm Rat, an Animal Model of Human Type 1 Diabetes (2022) (1)
- Potentiation of Lipotoxicity in Human EndoC-βH1 Β-cells by Glucose is Dependent on the Structure of Free Fatty Acids. (2023) (1)
- A plug-in minielectrode for measurements in stirred photometric cuvettes. (1996) (1)
- Cytotoxicity and activation of the Wnt/beta-catenin pathway in mouse embryonic stem cells treated with four GSK3 inhibitors (2014) (1)
- Influence of cytokines on Dmt 1 iron transporter and ferritin expression in insulin-secreting cells (2014) (1)
- MCPIP1 regulates the sensitivity of pancreatic beta-cells to cytokine toxicity (2019) (0)
- Current Status Glucokinase Regulation : History and A Fresh View of Glycolysis and Minireviews (2014) (0)
- Asymmetric dimethylation and citrullination in the LEW.1AR1-iddm rat, an animal model of human type 1 diabetes, and effects of anti-TCR/anti-TNF-α antibody-based therapy (2019) (0)
- Correction to: Translation of curative therapy concepts with T cell and cytokine antibody combinations for type 1 diabetes reversal in the IDDM rat (2021) (0)
- Structural requirements ofalloxan andninhydrin for glucokinase inhibition andofglucose forprotection against inhibition (1988) (0)
- Alterations in Energy Metabolism of Secretory Cells (2017) (0)
- The Generation of Definitive Endoderm from Human Embryonic Stem Cells is Initially Independent from Activin A but Requires Canonical Wnt-Signaling (2014) (0)
- An editorial on the article ‘Patents in the Diabetes Area in the Years 2008-2016’ (2018) (0)
- MicroRNA Target Sites as Genetic Tools to Enhance Promoter-Reporter Specificity for the Purification of Pancreatic Progenitor Cells from Differentiated Embryonic Stem Cells (2012) (0)
- Mechanism of pancreatic B-cell glucokinase inhibition by alloxan (1989) (0)
- Oxidative protein folding in the ER relies on a Protein Disulfide Isomerase (PDI) (2015) (0)
- Characteristics of 45ca2+ uptake into the la3+-nondisplacable (intracellular) pool of pancreatic islets. Abstr. (1976) (0)
- The pathology underlying beta cell destruction in four type 1 diabetes animal models in comparison with the human situation (2012) (0)
- Cytokines and islet beta-cell function (1994) (0)
- Effect of PFK-2 overexpression in insulin-producing cells upon glucokinase activity and glucose metabolism (2002) (0)
- Insulin Secretion and Metabolism of Pancreatic Islets from ob/ob Mice after Thyroxine Treatment (1978) (0)
- N-Arylsulfonyl-benzimidazolones as Potential Hypoglycemic Agents. (2002) (0)
- Relation Between Antioxidant Enzyme Gene Exmession and Antioxidative ~ e f e n s e Status of 1 ns ' ulin-producing Cells (2006) (0)
- TriPer, an optical probe tuned to the endoplasmic reticulum tracks changes in luminal H2O2 (2017) (0)
- Translation of curative therapy concepts with T cell and cytokine antibody combinations for type 1 diabetes reversal in the IDDM rat (2020) (0)
- 1 Results , meta-analysis and a first evaluation of U NOx R , the urinary nitrate-to-nitrite molar ratio , as a measure of nitrite reabsorption in experimental and clinical settings (2019) (0)
- Epigenetics of PNLIPRP1 in human pancreas reveals a molecular path between type 2 diabetes and pancreatic cancer (2022) (0)
- Anti-TCR therapy combined with fingolimod for reversal of diabetic hyperglycemia by β cell regeneration in the LEW.1AR1-iddm rat model of type 1 diabetes (2014) (0)
- Monoamine oxides in pancreatic islets, exocrine pancreas, and liver from rats. Characterization with clorgyline, deprenyl, pargyline, tranylcypromine, and amezinium (2004) (0)
- New micromethods for the investigation of calcium transport by subcellular organelles from endocrine tissues (1986) (0)
- Type 1 Diabetes Onset: A Story of Innate and Adaptive Immune Cells? (2015) (0)
- Effects of 4-methyl-2-methylenevalerate, a non-metabolizable analogue of 2-ketoisocaproate, on insulin secretion and metabolism inob/ob mouse pancreatic islets (1982) (0)
- Ca-ACCUMULATION OF INCUBATED MOUSE ISLETS (2008) (0)
- A Critical Re-Evaluation of CD24-Positivity of Human Embryonic Stem Cells Differentiated into Pancreatic Progenitors (2012) (0)
- TriPer, an optical probe tuned to the endoplasmic reticulum tracks H2O2 consumption by glutathione (2016) (0)
- The inductive effect of glibenclamide treatment on gluco- kinase is not a direct effect of glibenclamide but rather an effect of the insulin released from the pancreatic B-cells in response to glibenclamide (2002) (0)
- Influence of cytokines on Dmt1 iron transporter and ferritin expression in insulin-secreting cells (2014) (0)
- Possible mechanisms of damage and repair of pancreatic beta-cells in diabetes mellitus (1994) (0)
- Translation of curative therapy concepts with T cell and cytokine antibody combinations for type 1 diabetes reversal in the IDDM rat (2020) (0)
- Significance of microRNAs for the differentiation of human embryonic stem cells into definitive endoderm and mesoderm (2015) (0)
- Effects of tolbutamide and N -benzoyl- d -phenylalanine (NBDP) on the regulation of [Ca 2+ ] i oscillations in mouse pancreatic islets 1 1Abbreviations: KIC, α-ketoisocaproic acid; NBDP, N-benzoyl-d-phenylalanine; and SUR1, sulfonylurea receptor. (2001) (0)
- Interactions between endoplasmic reticulum and mitochondria in the regulation of pancreatic beta cell calcium transport (1987) (0)
- Comment on Binhai Ren et al. (2013; 15: 28–41): long‐term reversal of diabetes in non‐obese diabetic mice by liver‐directed gene therapy (2013) (0)
- A pivotal role of proinflammatory, cytokines in diabetes development and after recurrence of diabetes after pancreas transplantation in type 1 animal models (2008) (0)
- Effects of alpha-ketocarboxylic acids on 45ca++ uptake and insulin secretion by pancreatic ob/ob mouse islets. Abstr. (1978) (0)
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What Schools Are Affiliated With Sigurd Lenzen?
Sigurd Lenzen is affiliated with the following schools:
