Sijbren Otto
#46,203
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Dutch systems chemistry professor
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Chemistry
Sijbren Otto's Degrees
- PhD Chemistry University of Groningen
- Masters Chemistry University of Groningen
Why Is Sijbren Otto Influential?
(Suggest an Edit or Addition)According to Wikipedia, Sybren Otto is Professor of Systems chemistry at the Stratingh Institute for Chemistry, University of Groningen. Career Otto studied chemistry at the University of Groningen and in 1994, he received his Master’s degree, focusing on physical organic chemistry and biochemistry, with the distinction cum laude. In 1998, he obtained his PhD, again with the distinction cum laude, from his supervisor Prof. Jan B.F.N. Engberts for his thesis entitled Catalysis of Diels-Alder reactions in water.
Sijbren Otto's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Dynamic combinatorial chemistry. (2006) (1408)
- Supramolecular systems chemistry. (2015) (607)
- Mechanosensitive Self-Replication Driven by Self-Organization (2010) (398)
- Dynamic combinatorial libraries: from exploring molecular recognition to systems chemistry. (2013) (293)
- Selection and Amplification of Hosts From Dynamic Combinatorial Libraries of Macrocyclic Disulfides (2002) (267)
- Hydrophobic interactions and chemical reactivity. (2003) (244)
- Amplification of Acetylcholine-Binding Catenanes from Dynamic Combinatorial Libraries (2005) (219)
- Systems chemistry. (2020) (206)
- Dynamic Combinatorial Libraries of Macrocyclic Disulfides in Water (2000) (196)
- Reversible covalent chemistry in drug delivery. (2005) (163)
- Diels_Alder reactions in water (2000) (151)
- Diversification of self-replicating molecules. (2016) (148)
- Dynamic combinatorial libraries: new opportunities in systems chemistry. (2011) (142)
- Dynamic combinatorial optimization of a neutral receptor that binds inorganic anions in aqueous solution. (2003) (141)
- Lewis acid catalysis of a Diels-Alder reaction in water (1996) (138)
- Noncovalent interactions within a synthetic receptor can reinforce guest binding. (2006) (134)
- Dynamic molecular networks: from synthetic receptors to self-replicators. (2012) (129)
- Controlling the Structure and Length of Self-Synthesizing Supramolecular Polymers through Nucleated Growth and Disassembly. (2015) (128)
- Million-fold acceleration of a Diels-Alder reaction due to combined Lewis acid and micellar catalysis in water (1998) (123)
- Lithium-templated synthesis of a donor-acceptor pseudorotaxane and catenane. (2004) (118)
- A systematic study of ligand effects on a Lewis-acid-catalyzed Diels-Alder reaction in water. Water-enhanced enantioselectivity (1999) (114)
- Selection and amplification of a catalyst from a dynamic combinatorial library. (2003) (113)
- Effects of the Hydrophobicity of the Reactants on Diels-Alder Reactions in Water (1998) (110)
- Orthogonal or simultaneous use of disulfide and hydrazone exchange in dynamic covalent chemistry in aqueous solution. (2008) (110)
- Diels-Alder Reactions in Water. Effects of Hydrophobicity and Hydrogen Bonding (1994) (101)
- A chiral Lewis-acid-catalyzed Diels-Alder reaction. Water- enhanced enantioselectivity (1998) (98)
- Hydrogel formation upon photoinduced covalent capture of macrocycle stacks from dynamic combinatorial libraries. (2011) (97)
- Exponential self-replication enabled through a fibre elongation/breakage mechanism (2015) (97)
- Supramolecular templating in thermodynamically controlled synthesis (2002) (93)
- Recent developments in dynamic combinatorial chemistry. (2002) (91)
- Controlling the biological effects of spermine using a synthetic receptor. (2006) (90)
- Disulfides, imines, and metal coordination within a single system: interplay between three dynamic equilibria. (2007) (90)
- Diastereoselective amplification of an induced-fit receptor from a dynamic combinatorial library. (2005) (90)
- Welcome Home, Systems Chemists! (2010) (88)
- Dynamic combinatorial libraries of disulfide cages in water. (2005) (88)
- Dynamic combinatorial chemistry. (2002) (84)
- Competition between receptors in dynamic combinatorial libraries: amplification of the fittest? (2005) (83)
- Correlation between host-guest binding and host amplification in simulated dynamic combinatorial libraries. (2004) (81)
- Chemical systems out of equilibrium. (2017) (80)
- Expanding diversity in dynamic combinatorial libraries: simultaneous exchange of disulfide and thioester linkages. (2005) (79)
- A new cyclic pseudopeptide receptor for Li+ from a dynamic combinatorial library. (2001) (74)
- Uncovering the selection criteria for the emergence of multi-building-block replicators from dynamic combinatorial libraries. (2013) (73)
- The role of lipophilicity in transmembrane anion transport. (2012) (70)
- Exploring the relation between amplification and binding in dynamic combinatorial libraries of macrocyclic synthetic receptors in water. (2008) (67)
- Trends and Perspectives (2010) (67)
- Exploiting donor–acceptor interactions in aqueous dynamic combinatorial libraries: exploratory studies of simple systems (2010) (61)
- Recent highlights in systems chemistry. (2009) (61)
- Dynamic combinatorial discovery of a [2]-catenane and its guest-induced conversion into a molecular square host. (2008) (57)
- Redox Control over Acyl Hydrazone Photoswitches (2017) (57)
- Two-vial, LC-MS identification of ephedrine receptors from a solution-phase dynamic combinatorial library of over 9000 components. (2008) (56)
- Dynamic combinatorial development of a neutral synthetic receptor that binds sulfate with nanomolar affinity in aqueous solution. (2011) (56)
- Efficient and mild microwave-assisted stepwise functionalization of naphthalenediimide with alpha-amino acids. (2006) (56)
- Metal-ion induced amplification of three receptors from dynamic combinatorial libraries of peptide-hydrazones. (2003) (55)
- Transient substrate-induced catalyst formation in a dynamic molecular network. (2014) (49)
- Fragment Linking and Optimization of Inhibitors of the Aspartic Protease Endothiapepsin: Fragment‐Based Drug Design Facilitated by Dynamic Combinatorial Chemistry (2016) (49)
- Dynamic Combinatorial Libraries for the Development of Synthetic Receptors and Sensors (2007) (48)
- Towards open-ended evolution in self-replicating molecular systems (2017) (48)
- From self-replication to replicator systems en route to de novo life (2020) (48)
- Templated amplification of a naphthalenediimide-based receptor from a donor-acceptor dynamic combinatorial library in water. (2009) (47)
- Self-Assembly Can Direct Dynamic Covalent Bond Formation toward Diversity or Specificity (2017) (46)
- Complex Molecules That Fold Like Proteins Can Emerge Spontaneously (2018) (44)
- A catalyst for an acetal hydrolysis reaction from a dynamic combinatorial library (2005) (43)
- Host-guest binding constants can be estimated directly from the product distributions of dynamic combinatorial libraries. (2007) (40)
- What are the limits to the size of effective dynamic combinatorial libraries? (2004) (39)
- Systems chemistry. (2008) (39)
- Cation-reinforced donor-acceptor pseudorotaxanes (2005) (39)
- An "ingredients" approach to functional self-synthesizing materials: a metal-ion-selective, multi-responsive, self-assembled hydrogel. (2014) (39)
- Reinforced molecular recognition as an alternative to rigid receptors. (2006) (39)
- A "dial-a-receptor" dynamic combinatorial library. (2013) (39)
- Localized template-driven functionalization of nanoparticles by dynamic combinatorial chemistry. (2015) (37)
- Solvent composition dictates emergence in dynamic molecular networks containing competing replicators. (2015) (36)
- Emergence of light-driven protometabolism on recruitment of a photocatalytic cofactor by a self-replicator (2019) (35)
- Emergence of a New Self-Replicator from a Dynamic Combinatorial Library Requires a Specific Pre-Existing Replicator (2017) (33)
- LEWIS-ACID CATALYSIS OF A DIELS-ALDER REACTION IN WATER (1995) (33)
- Stable Polymer Micelles Formed by Metal Coordination (2012) (32)
- Optimization of the binding properties of a synthetic anion receptor using rational and combinatorial strategies. (2005) (31)
- Structural and Spectroscopic Properties of Assemblies of Self-Replicating Peptide Macrocycles (2017) (30)
- Template-Triggered Emergence of a Self-Replicator from a Dynamic Combinatorial Library. (2015) (30)
- Lewis‐acid catalysis of carbon carbon bond forming reactions in water (2010) (30)
- Antiparallel Dynamic Covalent Chemistries (2017) (29)
- The impact of the size of dynamic combinatorial libraries on the detectability of molecular recognition induced amplification. (2010) (29)
- The role of solvent cohesion in nonpolar solvation (2013) (28)
- Affinity chromatography in dynamic combinatorial libraries: one-pot amplification and isolation of a strongly binding receptor. (2010) (27)
- Chance emergence of catalytic activity and promiscuity in a self-replicator (2019) (27)
- Spontaneous Emergence of Self-Replicating Molecules Containing Nucleobases and Amino Acids (2020) (26)
- Catenanes from catenanes: quantitative assessment of cooperativity in dynamic combinatorial catenation (2014) (26)
- An allosteric receptor by simultaneous "casting" and "molding" in a dynamic combinatorial library. (2015) (25)
- Squeezing a Synthetic Ionophore and Mechanistic Insight Out of a Lipid Bilayer (1999) (25)
- Dynamic combinatorial chemistry at the phospholipid bilayer interface (2010) (25)
- Caught in the Act: Mechanistic Insight into Supramolecular Polymerization-Driven Self-Replication from Real-Time Visualization (2020) (24)
- Systems Chemistry: Pattern Formation in Random Dynamic Combinatorial Libraries (2007) (24)
- A synthetic receptor for nicotine from a dynamic combinatorial library. (2012) (23)
- Modular Control over the Selectivity of Self-Assembling and Membrane-Spanning Ion Conductors (1999) (22)
- Tailored polymer-supported templates in dynamic combinatorial libraries: simultaneous selection, amplification and isolation of synthetic receptors. (2008) (21)
- Systems chemistry: pattern formation in random dynamic combinatorial libraries. (2007) (20)
- Parasitic Behavior of Self-Replicating Molecules. (2018) (20)
- Systems chemistry: a web themed issue. (2014) (19)
- Exploring and exploiting molecular recognition using covalent chemistry under thermodynamic control (2005) (19)
- Complexation of diphenyl(phenylacetenyl)phosphine to rhodium(III) tetraphenyl porphyrins: synthesis and structural, spectroscopic, and thermodynamic studies. (2003) (18)
- Photo-induced molecular-recognition-mediated adhesion of giant vesicles. (2009) (17)
- Polymer-supported cationic templates for molecular recognition of anionic hosts in water. (2008) (16)
- Estimating equilibrium constants for aggregation from the product distribution of a dynamic combinatorial library. (2009) (16)
- Chemical Fueling Enables Molecular Complexification of Self‐Replicators** (2021) (15)
- Instructable Nanoparticles Using Dynamic Combinatorial Chemistry. (2015) (15)
- Diels—Alder Reactions in Water (2001) (14)
- Dynamic combinatorial chemistry: a new method for selection and preparation of synthetic receptors. (2003) (13)
- Controlling the morphology of aggregates of an amphiphilic synthetic receptor through host-guest interactions. (2006) (13)
- Effector-Triggered Self-Replication in Coupled Subsystems. (2017) (13)
- Emergence of low-symmetry foldamers from single monomers (2020) (13)
- Mechanism of Building Block Exchange in Stacks of Self-Replicating Macrocycles (2016) (12)
- Systems chemistry: using thermodynamically controlled networks to assess molecular similarity (2013) (12)
- Detection of Nonideal Mixing of Phospholipids in Fluid Bilayers (2000) (10)
- Existing Self-Replicators Can Direct the Emergence of New Ones. (2018) (10)
- Molecular self-assembly: helping themselves. (2009) (10)
- Lewis Acid Catalysis of a Diels‐Alder Reaction in Water. (1996) (10)
- An Approach to the De Novo Synthesis of Life (2021) (10)
- Dynamic Combinatorial Libraries: New Opportunities in Systems Chemistry (2011) (10)
- Molecular machines: tiny steps. (2010) (10)
- Ion Conductors that Favor Passive Transport in Ergosterol-Rich over Cholesterol-Rich Phospholipid Membranes (2000) (10)
- Dynamic Combinatorial Libraries: From Exploring Molecular Recognition to Systems Chemistry (2013) (9)
- Enhanced rigidity and rupture strength of composite hydrogel networks of bio-inspired block copolymers (2013) (9)
- Template-promoted self-replication in dynamic combinatorial libraries made from a simple building block. (2018) (9)
- Apparent non-statistical binding in a ditopic receptor for guanosine. (2009) (7)
- Multi-step control over self-assembled hydrogels of peptide-derived building blocks and a polymeric cross-linker. (2016) (7)
- Dynamic Combinatorial Libraries (2017) (5)
- Water as a Green Solvent (2012) (5)
- Water and Deuterium Oxide (2012) (4)
- Two Sides of the Same Coin: Emergence of Foldamers and Self-Replicators from Dynamic Combinatorial Libraries (2021) (4)
- Diels-Alder reactions in micellar media (2010) (4)
- Catalysis of Diels-Alder reactions in water (1998) (4)
- Out‐of‐Equilibrium Self‐Replication Allows Selection for Dynamic Kinetic Stability in a System of Competing Replicators (2022) (3)
- Self‐Sorting in Dynamic Combinatorial Libraries Leads to the Co‐Existence of Foldamers and Self‐Replicators (2021) (2)
- Emergence of Compartments Formed from Unconventional Surfactants in Dynamic Combinatorial Libraries (2019) (2)
- Million-Fold Acceleration of a Diels—Alder Reaction due to Combined Lewis Acid and Micellar Catalysis in Water. (1999) (2)
- Parasitic Behavior of Self‐Replicating Molecules (2018) (1)
- Solvent Properties of Water (2012) (1)
- Lewis Acid Catalysis of Carbon‐Carbon Bond Forming Reactions in Water (1997) (1)
- Cohesive Energy Density (2012) (1)
- Automated device for continuous stirring while sampling in liquid chromatography systems (2020) (1)
- An Optical Probe for Real-Time Monitoring of Self-Replicator Emergence and Distinguishing between Replicators (2021) (1)
- Cross-Catalysis between Self-Replicators of Different Handedness (2019) (1)
- The Ionic Product of Water: Proton and Hydroxide Ion Mobilities (2012) (1)
- Creative Chemical Sensor Systems (2007) (1)
- Spontaneous and Template-Directed Emergence of Low-Symmetry Foldamers from Dynamic Homomeric Sequences (2019) (1)
- Reaction: Thinking-Species Chemistry and the World’s Problems (2017) (1)
- Stoichiometry alone can steer supramolecular systems on complex free energy surfaces with high selectivity (2021) (1)
- How hydrophobicity dictates the size of self-replicating self-assembling macrocycles (2012) (0)
- Aqueous Electrolyte Solutions (2012) (0)
- University of Groningen Self-Assembly Can Direct Dynamic Covalent Bond Formation Towards Diversity or Specificity (2018) (0)
- Selection of diverse polymorphic structures from a small dynamic molecular network controlled by the environment (2022) (0)
- University of Groningen Catalysis of Diels-Alder reactions in water (2018) (0)
- Emergent Catalysis by Self‐Replicating Molecules (2021) (0)
- Teaching an Old Compound New Tricks: Reversible Transamidation in Maleamic Acids (2022) (0)
- Competition Dynamics in a Chemical System of Self-replicating Macrocycles (2020) (0)
- Automated Stirring Device for Continuous Stirring While Sampling in Liquid Chromatography Systems (2020) (0)
- Bringing Supramolecular Chemistry to Life (2007) (0)
- Recent Developments in Dynamic Combinatorial Chemistry (2002) (0)
- Chemical Fueling Enables Molecular Complexification of Assembly-Driven Self-Replicators (2020) (0)
- Catalysis in Water (2012) (0)
- INSIGHTS INTO THE EMERGENCE OF REPLICATION , HEREDITY , AND SPECIATION IN ABIOTIC SYSTEMS (2017) (0)
- Water as a Reaction Medium for Organic Synthesis (2012) (0)
- Solvatochromic Solvent Parameters (2012) (0)
- Organic Reactivity in Water (2012) (0)
- thermodynamically controlled synthesis Supramolecular Chemistry And Self-assembly Special Feature : Supramolecular templating in (2002) (0)
- Controlling Supramolecular Plasticity through Stoichiometry (2019) (0)
- Effects of Additives on Reactivity in Water (2012) (0)
- University of Groningen Antiparallel Dynamic Covalent Chemistries (2017) (0)
- The Practice of Dynamic Combinatorial Libraries: Analytical Chemistry, Experimental Design, and Data Analysis (2010) (0)
- Reactions in Supercritical Water (2012) (0)
- Solvent Polarity Indicators (2012) (0)
- Dynamic Combinatorial Chemistry Out of Equilibrium (2021) (0)
- Hydrophobic Effects on Reactivity: Initial-State versus Transition-State Effects (2012) (0)
- Thermodynamics of Hydration (2012) (0)
- (Re-)Directing Oligomerization of a Single Building Block into Two Specific Dynamic Covalent Foldamers through pH (2023) (0)
- Stochastic Emergence of Two Distinct Self-Replicators from a Dynamic Combinatorial Library (2022) (0)
- Systems Chemistry: Pattern Formation in Random Dynamic (2007) (0)
- The Solvatochromic Comparison Method: Linear Solvation Energy Relationships (2012) (0)
- The Size of the Water Molecule (2012) (0)
- Dynamics of Ion Hydration (2012) (0)
- Water at High and Low Temperatures and Pressures (2012) (0)
- POLY 680-Supramolecular binding of protonated amines to functionalized microgel particles (2006) (0)
- Development of Stable Iron Oxide Nanoparticles for Dynamic Covalent Surface Functionalization (2020) (0)
- The Single Water Molecule (2012) (0)
- Molecular Recognition and Self-Replication in Dissipative Molecular Networks (2013) (0)
- Emergence and Evolution of Complex Chemical Systems (2018) (0)
- Accelerating Hydrazone Exchange by UV Irradiation (2020) (0)
- Tailorable and Biocompatible Supramolecular-Based Hydrogels Featuring two Dynamic Covalent Chemistries. (2023) (0)
- Template Assisted Emergence of a Novel Self-Replicating Peptide from Dynamic Combinatorial Libraries (2016) (0)
- Reactions “On Water” (2012) (0)
- Trends and Perspectives in Dynamic Combinatorial Chemistry (2012) (0)
- University of Groningen Welcome Home , Systems Chemists ! (2019) (0)
- Ionic Hydration: Hydration Numbers (2012) (0)
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