Sima Lev
#184,037
Most Influential Person Now
Researcher
Sima Lev's AcademicInfluence.com Rankings
Sima Levcomputer-science Degrees
Computer Science
#11777
World Rank
#12530
Historical Rank
Machine Learning
#5417
World Rank
#5488
Historical Rank
Artificial Intelligence
#5844
World Rank
#5933
Historical Rank
Database
#8860
World Rank
#9308
Historical Rank
Download Badge
Computer Science
Sima Lev's Degrees
- PhD Computer Science Stanford University
- Masters Computer Science University of California, Berkeley
- Bachelors Computer Science University of California, Berkeley
Similar Degrees You Can Earn
Why Is Sima Lev Influential?
(Suggest an Edit or Addition)According to Wikipedia, Sima Lev is an Israeli biologist and the Joyce and Ben B. Eisenberg Professorial Chair of Molecular Cell Biology at the Weizmann Institute of Science. She looks to uncover the mechanisms that drive the development of triple-negative breast cancer, and to identify new therapeutic strategies.
Sima Lev's Published Works
Published Works
- Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions (1995) (1426)
- A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation (1996) (1027)
- RNA interference screen for human genes associated with West Nile virus infection (2008) (505)
- Non-vesicular lipid transport by lipid-transfer proteins and beyond (2010) (309)
- Coordinated lipid transfer between the endoplasmic reticulum and the Golgi complex requires the VAP proteins and is essential for Golgi-mediated transport. (2008) (303)
- Tethering the assembly of SNARE complexes. (2014) (278)
- Activation of Pyk2 by Stress Signals and Coupling with JNK Signaling Pathway (1996) (259)
- The VAP protein family: from cellular functions to motor neuron disease. (2008) (214)
- Sprouty Fine-Tunes EGF Signaling through Interlinked Positive and Negative Feedback Loops (2003) (191)
- Differential Regulation of Endoplasmic Reticulum Structure through VAP-Nir Protein Interaction* (2005) (184)
- Tyrosine Phosphorylation of Pyk2 Is Selectively Regulated by Fyn During TCR Signaling (1997) (173)
- Maintenance of the diacylglycerol level in the Golgi apparatus by the Nir2 protein is critical for Golgi secretory function (2005) (162)
- The fourth immunoglobulin domain of the stem cell factor receptor couples ligand binding to signal transduction (1995) (160)
- Dimerization and activation of the kit receptor by monovalent and bivalent binding of the stem cell factor. (1992) (142)
- Identification of a Novel Family of Targets of PYK2 Related to Drosophila Retinal Degeneration B (rdgB) Protein (1999) (142)
- A specific combination of substrates is involved in signal transduction by the kit‐encoded receptor. (1991) (137)
- Interkinase domain of kit contains the binding site for phosphatidylinositol 3' kinase. (1992) (124)
- Steel factor and c-kit protooncogene: genetic lessons in signal transduction. (1994) (110)
- Nonvesicular lipid transfer from the endoplasmic reticulum. (2012) (102)
- MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells (2016) (100)
- Direct interaction between the COG complex and the SM protein, Sly1, is required for Golgi SNARE pairing (2009) (97)
- The phosphatidylinositol‐transfer protein Nir2 binds phosphatidic acid and positively regulates phosphoinositide signalling (2013) (96)
- The COG complex interacts directly with Syntaxin 6 and positively regulates endosome-to-TGN retrograde transport (2011) (93)
- Targeting of PYK2 to Focal Adhesions as a Cellular Mechanism for Convergence between Integrins and G Protein-coupled Receptor Signaling Cascades* (2000) (92)
- Enhanced Activity of a Large Conductance, Calcium-sensitive K+ Channel in the Presence of Src Tyrosine Kinase* (2000) (89)
- Mitotic phosphorylation of the peripheral Golgi protein Nir2 by Cdk1 provides a docking mechanism for Plk1 and affects cytokinesis completion. (2004) (86)
- Interspecies molecular chimeras of kit help define the binding site of the stem cell factor (1993) (85)
- Structural Requirements for VAP-B Oligomerization and Their Implication in Amyotrophic Lateral Sclerosis-associated VAP-B(P56S) Neurotoxicity* (2010) (72)
- A disaccharide derived from chondroitin sulphate proteoglycan promotes central nervous system repair in rats and mice † (2004) (71)
- Cerebral Ischemia and Seizures Induce Tyrosine Phosphorylation of PYK2 in Neurons and Microglial Cells (2000) (68)
- Soluble c-kit proteins and antireceptor monoclonal antibodies confine the binding site of the stem cell factor. (1993) (63)
- PYK2 sustains endosomal-derived receptor signalling and enhances epithelial-to-mesenchymal transition (2015) (60)
- The role of the Nir/rdgB protein family in membrane trafficking and cytoskeleton remodeling. (2004) (59)
- A recombinant ectodomain of the receptor for the stem cell factor (SCF) retains ligand-induced receptor dimerization and antagonizes SCF-stimulated cellular responses. (1992) (56)
- Targeting of Nir2 to Lipid Droplets Is Regulated by a Specific Threonine Residue within Its PI-Transfer Domain (2002) (52)
- Depolarization Activates ERK and Proline-rich Tyrosine Kinase 2 (PYK2) Independently in Different Cellular Compartments in Hippocampal Slices* (2005) (51)
- The COG complex interacts with multiple Golgi SNAREs and enhances fusogenic assembly of SNARE complexes (2013) (51)
- Nir2, a Human Homolog of Drosophila melanogaster Retinal Degeneration B Protein, Is Essential for Cytokinesis (2002) (49)
- Targeting of PYK2 Synergizes with EGFR Antagonists in Basal-like TNBC and Circumvents HER3-Associated Resistance via the NEDD4-NDRG1 Axis. (2017) (48)
- Targeted therapy and drug resistance in triple-negative breast cancer: the EGFR axis. (2020) (45)
- Synthetic lethal combination targeting BET uncovered intrinsic susceptibility of TNBC to ferroptosis (2020) (42)
- Structure‐function analyses of the kit receptor for the steel factor (1993) (42)
- Proteomic analysis of circulating extracellular vesicles identifies potential markers of breast cancer progression, recurrence, and response (2020) (37)
- PYK2 integrates growth factor and cytokine receptors signaling and potentiates breast cancer invasion via a positive feedback loop (2015) (31)
- Molecular Aspects of Retinal Degenerative Diseases (2001) (31)
- Lipid homoeostasis and Golgi secretory function. (2006) (30)
- VAMP-Associated Protein B (VAPB) Promotes Breast Tumor Growth by Modulation of Akt Activity (2012) (27)
- Receptor functions and ligand-dependent transforming potential of a chimeric kit proto-oncogene (1990) (24)
- Lipid Transfer Proteins and Membrane Contact Sites in Human Cancer (2020) (24)
- The lipid-transfer protein Nir2 enhances epithelial-mesenchymal transition and facilitates breast cancer metastasis (2014) (23)
- Deficiency of the Cog8 Subunit in Normal and CDG‐Derived Cells Impairs the Assembly of the COG and Golgi SNARE Complexes (2013) (23)
- Nir2, a Novel Regulator of Cell Morphogenesis (2002) (21)
- PYK2 negatively regulates the Hippo pathway in TNBC by stabilizing TAZ protein (2018) (21)
- Targeting of apoptotic pathways by SMAC or BH3 mimetics distinctly sensitizes paclitaxel-resistant triple negative breast cancer cells (2017) (20)
- The Animal Lectin Galectin-8 Promotes Cytokine Expression and Metastatic Tumor Growth in Mice (2020) (19)
- The role of phosphatidylinositol-transfer proteins at membrane contact sites. (2016) (18)
- Systems modelling of the EGFR-PYK2-c-Met interaction network predicts and prioritizes synergistic drug combinations for triple-negative breast cancer (2018) (17)
- Cellular and developmental distribution of human homologues of the Drosophilia rdgB protein in the rat retina. (2002) (13)
- Modeling Heterogeneity of Triple‐Negative Breast Cancer Uncovers a Novel Combinatorial Treatment Overcoming Primary Drug Resistance (2020) (9)
- Mammalian PITPs at the Golgi and ER-Golgi Membrane Contact Sites (2020) (4)
- The AXL-PYK2-PKCα axis as a nexus of stemness circuits in TNBC (2021) (3)
- Mouse Modeling Dissecting Macrophage–Breast Cancer Communication Uncovered Roles of PYK2 in Macrophage Recruitment and Breast Tumorigenesis (2022) (3)
- Nucleoporin-93 reveals a common feature of aggressive breast cancers: robust nucleocytoplasmic transport of transcription factors. (2022) (3)
- Accelerating AXL targeting for TNBC therapy. (2021) (2)
- BCL-XL blockage in TNBC models confers vulnerability to inhibition of specific cell cycle regulators (2021) (2)
- Receptor Functions andLigand-Dependent Transforming Potential ofa Chimeric kitProto-Oncogene (1990) (1)
- Nucleoporin-93 overexpression overcomes multiple nucleocytoplsamic trafficking bottlenecks to permit robust metastasis (2020) (1)
- The role of Lipid transfer proteins in membrane trafficking and signal transduction (2013) (1)
- Award Number: W81XWH-10-1-0256 TITLE: Role of VAPB-MSP, a Novel EphA2 RTK Antagonist in Breast Cancer (2013) (0)
- Lipid and vesicle biogenesis at the Golgi membranes (2006) (0)
- PYK2 negatively regulates the Hippo pathway in TNBC by stabilizing TAZ protein (2018) (0)
- Correction: The lipid-transfer protein Nir2 enhances epithelial-mesenchymal transition and facilitates breast cancer metastasis (doi:10.1242/jcs.155721) (2019) (0)
- Lipid Transfer Proteins and Membrane Contact Sites in Human Cancer. (2019) (0)
- The Animal Lectin Galectin-8 Promotes Cytokine Expression and Metastatic Tumor Growth in Mice (2020) (0)
- The Kit Receptor for the Stem Cell Factor: Genetic Lessons in Signal Transduction (1992) (0)
- Golgi proteins in mitosis and cytokinesis (2005) (0)
- Correction: Targeting of PYK2 Synergizes with EGFR Antagonists in Basal-like TNBC and Circumvents HER3-Associated Resistance via the NEDD4-NDRG1 Axis. (2020) (0)
- PO-139 Identify rational drug combinations for triple negative breast cancer by integrative network modelling (2018) (0)
- Modeling heterogeneity of Triple-Negative Breast Cancer highlights potency of WEE1 and BCL-XL targeting (2020) (0)
- Nucleoporin-93 Overcomes Multiple Nucleocytoplasmic Trafficking Bottlenecks and Permits Robust Metastasis (2021) (0)
This paper list is powered by the following services:
Other Resources About Sima Lev
What Schools Are Affiliated With Sima Lev?
Sima Lev is affiliated with the following schools: