Simon Boulton
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British scientist
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Why Is Simon Boulton Influential?
(Suggest an Edit or Addition)According to Wikipedia, Simon Joseph Boulton is a British scientist who has made important contributions to the understanding of DNA repair and the treatment of cancer resulting from DNA damage. He currently occupies the position of Senior Scientist and group leader of the DSB Repair Metabolism Laboratory at the Francis Crick Institute, London. He is also an honorary Professor at University College London.
Simon Boulton's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Playing the end game: DNA double-strand break repair pathway choice. (2012) (1404)
- Double-strand break repair: 53BP1 comes into focus (2013) (873)
- Components of the Ku‐dependent non‐homologous end‐joining pathway are involved in telomeric length maintenance and telomeric silencing (1998) (652)
- RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection (2013) (588)
- Poly(ADP-ribose)–Dependent Regulation of DNA Repair by the Chromatin Remodeling Enzyme ALC1 (2009) (530)
- Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double‐strand break repair and serves as a barrier to error‐prone DNA repair pathways. (1996) (519)
- Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance. (1996) (508)
- Homologous recombination-deficient tumors are hyper-dependent on POLQ-mediated repair (2015) (487)
- REV7 counteracts DNA double-strand break resection and affects PARP inhibition (2015) (478)
- RTEL1 Dismantles T Loops and Counteracts Telomeric G4-DNA to Maintain Telomere Integrity (2012) (396)
- C. elegans ORFeome version 1.1: experimental verification of the genome annotation and resource for proteome-scale protein expression (2003) (392)
- Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins (2008) (388)
- The C. elegans homolog of the p53 tumor suppressor is required for DNA damage-induced apoptosis (2001) (358)
- RTEL1 Maintains Genomic Stability by Suppressing Homologous Recombination (2008) (343)
- Cellular functions of the BRCA tumour-suppressor proteins. (2006) (307)
- Preventing nonhomologous end joining suppresses DNA repair defects of Fanconi anemia. (2010) (302)
- BRCA1-associated exclusion of 53BP1 from DNA damage sites underlies temporal control of DNA repair (2012) (298)
- Combined Functional Genomic Maps of the C. elegans DNA Damage Response (2002) (296)
- Caenorhabditis elegans HUS-1 Is a DNA Damage Checkpoint Protein Required for Genome Stability and EGL-1-Mediated Apoptosis (2002) (269)
- A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination. (2007) (234)
- FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex. (2008) (225)
- FANCJ Is a Structure-specific DNA Helicase Associated with the Maintenance of Genomic G/C Tracts* (2008) (225)
- Mechanisms of Oncogene-Induced Replication Stress: Jigsaw Falling into Place. (2018) (213)
- Inhibition of homologous recombination by the PCNA-interacting protein PARI. (2012) (212)
- HTP-3 links DSB formation with homolog pairing and crossing over during C. elegans meiosis. (2008) (209)
- MMS19 Links Cytoplasmic Iron-Sulfur Cluster Assembly to DNA Metabolism (2012) (198)
- A protein–protein interaction map of the Caenorhabditis elegans 26S proteasome (2001) (186)
- Distinct modes of ATR activation after replication stress and DNA double‐strand breaks in Caenorhabditis elegans (2005) (184)
- CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability. (2010) (181)
- RTEL1 Is a Replisome-Associated Helicase That Promotes Telomere and Genome-Wide Replication (2013) (181)
- RAD-51-Dependent and -Independent Roles of a Caenorhabditis elegans BRCA2-Related Protein during DNA Double-Strand Break Repair (2005) (174)
- Structural genomics: A pipeline for providing structures for the biologist (2002) (169)
- The choice in meiosis – defining the factors that influence crossover or non-crossover formation (2011) (164)
- Mechanisms of DNA–protein crosslink repair (2017) (163)
- RTEL-1 Enforces Meiotic Crossover Interference and Homeostasis (2010) (163)
- BRCA1/BARD1 Orthologs Required for DNA Repair in Caenorhabditis elegans (2004) (159)
- A conserved pathway to activate BRCA1‐dependent ubiquitylation at DNA damage sites (2006) (157)
- Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN (2016) (156)
- Yeast Two-Hybrid Systems and Protein Interaction Mapping Projects for Yeast and Worm (2000) (154)
- BOD1L Is Required to Suppress Deleterious Resection of Stressed Replication Forks. (2015) (145)
- Cdc28-Clb5 (CDK-S) and Cdc7-Dbf4 (DDK) collaborate to initiate meiotic recombination in yeast. (2008) (138)
- Regulation of DNA Repair pathway choice in S/G2 by the NHEJ inhibitor CYREN (2017) (122)
- NEK8 links the ATR-regulated replication stress response and S phase CDK activity to renal ciliopathies. (2013) (120)
- HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability (2007) (120)
- A Recessive Founder Mutation in Regulator of Telomere Elongation Helicase 1, RTEL1, Underlies Severe Immunodeficiency and Features of Hoyeraal Hreidarsson Syndrome (2013) (117)
- Rad51 Paralogs Remodel Pre-synaptic Rad51 Filaments to Stimulate Homologous Recombination (2015) (117)
- Caenorhabditis elegans HIM-18/SLX-4 Interacts with SLX-1 and XPF-1 and Maintains Genomic Integrity in the Germline by Processing Recombination Intermediates (2009) (116)
- Moving From Poly (ADP-Ribose) Polymerase Inhibition to Targeting DNA Repair and DNA Damage Response in Cancer Therapy. (2019) (111)
- RTEL1: an essential helicase for telomere maintenance and the regulation of homologous recombination (2010) (110)
- DOG-1 Is the Caenorhabditis elegans BRIP1/FANCJ Homologue and Functions in Interstrand Cross-Link Repair (2007) (108)
- Inhibitors of the proteasome suppress homologous DNA recombination in mammalian cells. (2007) (104)
- Human RIF1 and protein phosphatase 1 stimulate DNA replication origin licensing but suppress origin activation (2017) (101)
- Caenorhabditis elegans POLQ-1 and HEL-308 function in two distinct DNA interstrand cross-link repair pathways. (2008) (97)
- RTEL1: functions of a disease-associated helicase. (2014) (97)
- BRC‐1 acts in the inter‐sister pathway of meiotic double‐strand break repair (2008) (95)
- Overlapping mechanisms promote postsynaptic RAD-51 filament disassembly during meiotic double-strand break repair. (2010) (93)
- Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance (2021) (90)
- The centriolar satellite protein Cep131 is important for genome stability (2012) (85)
- Replication blocking lesions present a unique substrate for homologous recombination (2007) (80)
- TRF2 Recruits RTEL1 to Telomeres in S Phase to Promote T-Loop Unwinding (2016) (79)
- TRF2 Recruits RTEL1 to Telomeres in S Phase to Promote T-Loop Unwinding (2015) (76)
- Stabilization of Reversed Replication Forks by Telomerase Drives Telomere Catastrophe (2017) (76)
- Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability (2017) (73)
- Stabilization of RAD-51–DNA filaments via an interaction domain in Caenorhabditis elegans BRCA2 (2007) (73)
- Molecular basis of telomere dysfunction in human genetic diseases (2015) (73)
- Phosphorylation-Dependent PIH1D1 Interactions Define Substrate Specificity of the R2TP Cochaperone Complex (2014) (72)
- CeBRC-2 stimulates D-loop formation by RAD-51 and promotes DNA single-strand annealing. (2006) (70)
- Joint Molecule Resolution Requires the Redundant Activities of MUS-81 and XPF-1 during Caenorhabditis elegans Meiosis (2013) (67)
- Genomic landscape of oxidative DNA damage and repair reveals regioselective protection from mutagenesis (2017) (64)
- C. elegans FANCD2 responds to replication stress and functions in interstrand cross-link repair. (2006) (63)
- POLE3-POLE4 Is a Histone H3-H4 Chaperone that Maintains Chromatin Integrity during DNA Replication (2018) (63)
- Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN (2017) (62)
- Metabolism of DNA secondary structures at the eukaryotic replication fork. (2014) (59)
- Abrogation of the CLK‐2 checkpoint leads to tolerance to base‐excision repair intermediates (2006) (59)
- A role for Ebi in neuronal cell cycle control (2000) (58)
- Tripartite Motif-containing 33 (TRIM33) Protein Functions in the Poly(ADP-ribose) Polymerase (PARP)-dependent DNA Damage Response through Interaction with Amplified in Liver Cancer 1 (ALC1) Protein* (2013) (55)
- Emerging links between the biological clock and the DNA damage response (2007) (54)
- The MRT‐1 nuclease is required for DNA crosslink repair and telomerase activity in vivo in Caenorhabditis elegans (2009) (53)
- DNA Polymerase Epsilon Deficiency Causes IMAGe Syndrome with Variable Immunodeficiency (2018) (53)
- Polε Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis (2018) (53)
- Beyond PARP—POLθ as an anticancer target (2018) (52)
- CDK phosphorylation of TRF2 controls t-loop dynamics during the cell cycle (2019) (51)
- BRCA1-Mediated Ubiquitylation (2006) (50)
- HELQ promotes RAD51 paralog-dependent repair to avert germ cell attrition and tumourigenesis (2013) (48)
- Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD (2020) (47)
- FANCJ suppresses microsatellite instability and lymphomagenesis independent of the Fanconi anemia pathway (2015) (47)
- SLX4IP Antagonizes Promiscuous BLM Activity during ALT Maintenance (2019) (47)
- Meiotic recombination in Caenorhabditis elegans (2007) (46)
- Tandem immunoaffinity purification of protein complexes from Caenorhabditis elegans. (2004) (43)
- IKKα Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer (2019) (42)
- Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors (2021) (41)
- Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1 (2017) (40)
- Ccdc13 is a novel human centriolar satellite protein required for ciliogenesis and genome stability (2014) (37)
- Single-molecule analysis reveals cooperative stimulation of Rad51 filament nucleation and growth by mediator proteins (2020) (37)
- MRE11 stability is regulated by CK2-dependent interaction with R2TP complex (2017) (36)
- C. elegans: a model of Fanconi anemia and ICL repair. (2009) (36)
- The centriolar satellite protein Cep131 is important for genome stability (2013) (35)
- A Polar and Nucleotide-Dependent Mechanism of Action for RAD51 Paralogs in RAD51 Filament Remodeling (2016) (35)
- Induction of APOBEC3 exacerbates DNA replication stress and chromosomal instability in early breast and lung cancer evolution. (2021) (32)
- Clinical and Molecular Heterogeneity of RTEL1 Deficiency (2017) (31)
- A Distinct Class of Genome Rearrangements Driven by Heterologous Recombination (2018) (30)
- TRF2-independent chromosome end protection during pluripotency (2020) (30)
- RTEL1 Inhibits Trinucleotide Repeat Expansions and Fragility (2014) (29)
- Defining the influence of Rad51 and Dmc1 lineage-specific amino acids on genetic recombination (2019) (26)
- Alternative Induction of Meiotic Recombination From Single-Base Lesions of DNA Deaminases (2009) (23)
- RTEL1 Regulates G4/R-Loops to Avert Replication-Transcription Collisions (2020) (23)
- RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection (2021) (22)
- Metabolism of postsynaptic recombination intermediates (2010) (22)
- BRCA1 ubiquitylation of CtIP: Just the tIP of the iceberg? (2006) (20)
- The end protection problem—an unexpected twist in the tail (2020) (19)
- A Meiotic Checkpoint Alters Repair Partner Bias to Permit Inter-sister Repair of Persistent DSBs (2019) (19)
- Spotlight on the Replisome: Aetiology of DNA Replication-Associated Genetic Diseases. (2020) (18)
- FANCM-FAAP24 and HCLK2: Roles in ATR signalling and the Fanconi Anemia pathway (2009) (17)
- REC-1 and HIM-5 distribute meiotic crossovers and function redundantly in meiotic double-strand break formation in Caenorhabditis elegans (2015) (17)
- High-throughput expression, purification, and characterization of recombinant Caenorhabditis elegans proteins. (2003) (16)
- HELQ is a dual-function DSB repair enzyme modulated by RPA and RAD51 (2021) (14)
- DNA repair: Decision at the break point (2010) (14)
- Mechanistic Insights into Regulation of the ALC1 Remodeler by the Nucleosome Acidic Patch (2020) (13)
- Tousled-Like Kinases Suppress Innate Immune Signaling Triggered by Alternative Lengthening of Telomeres (2020) (12)
- Tackling PARP inhibitor resistance. (2021) (10)
- Protection of the C. elegans germ cell genome depends on diverse DNA repair pathways during normal proliferation (2021) (10)
- Single-molecule visualization of human RECQ5 interactions with single-stranded DNA recombination intermediates (2020) (9)
- Oncogenic herpesvirus KSHV triggers hallmarks of alternative lengthening of telomeres (2021) (9)
- FANCM: fork pause, rewind and play (2010) (8)
- Use of protein-interaction maps to formulate biological questions. (2001) (8)
- A protein – protein interaction map of the Caenorhabditis elegans 26 S proteasome (2013) (7)
- POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells. (2022) (7)
- Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome (2021) (6)
- A C-circle assay for detection of alternative lengthening of telomere activity in FFPE tissue (2021) (6)
- Synthetic Lethality between DNA Polymerase Epsilon and RTEL1 in Metazoan DNA Replication (2020) (6)
- H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ (2022) (6)
- SMCHD1 promotes ATM‐dependent DNA damage signaling and repair of uncapped telomeres (2020) (6)
- Generation of versatile ss-dsDNA hybrid substrates for single-molecule analysis (2021) (5)
- The leukemia-associated Rho guanine nucleotide exchange factor LARG is required for efficient replication stress signaling (2014) (5)
- REV 7 counteracts DNA double-strand break resection and impacts PARP inhibition (2015) (5)
- How to exchange your partner (2007) (4)
- Mechanism of mitotic recombination: insights from C. elegans (2021) (4)
- DNA repair: A heavyweight joins the fray (2009) (4)
- Helicase and translocases required for the maintenance of genome stability. (2010) (3)
- 1 BOD 1 L IS REQUIRED TO SUPPRESS DELETERIOUS RESECTION OF STRESSED 1 REPLICATION FORKS 2 3 (2015) (3)
- The APE2 nuclease is essential for DNA double strand break repair by microhomology-mediated end-joining (2022) (2)
- RTEL1 Inhibits Trinucleotide Repeat Expansions and Fragility. (2016) (2)
- Lawrence Berkeley National Laboratory Recent Work Title Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease (2)
- Systematic analysis of mutational spectra associated with DNA repair deficiency in C. elegans (2020) (2)
- Cendra Agulhon , Signaling 2 + Not Modulated by Astrocyte Ca Hippocampal Short-and Long-Term Plasticity (2)
- Disrupted control of origin activation compromises genome integrity upon destabilization of Polε and dysfunction of the TRP53-CDKN1A/P21 axis (2022) (1)
- New Editor-in-Chief—welcome to Simon Boulton! (2018) (1)
- Abstract 5697: Targeting PARP inhibitor resistance with Polθ inhibitors (2022) (1)
- Differential regulation of the PIKK kinase family by Tel2 (2008) (1)
- Dragana Ahel , Repair by the Chromatin Remodeling Enzyme ALC 1 Poly ( ADP-ribose ) Dependent Regulation of DNA (2010) (1)
- Faculty Opinions recommendation of The BRIP1 helicase functions independently of BRCA1 in the Fanconi anemia pathway for DNA crosslink repair. (2006) (1)
- Nucleotide proofreading functions by nematode RAD51 paralogs facilitate optimal RAD51 filament function (2021) (1)
- Genomic landscape of oxidative DNA damage and repair reveals regioselective protection from mutagenesis (2018) (1)
- C. elegans POLQ-1 and HEL-308 function in two distinct DNA interstrand cross-link repair pathways (2008) (1)
- Condensin(g) Crossover Control to a Few Breaks (2009) (1)
- Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models (2022) (1)
- Search and processing of Holliday junctions within long DNA by junction-resolving enzymes (2022) (0)
- Crystal structure of the Wss1 E203Q mutant from S. pombe (2016) (0)
- Youds , and Homeostasis RTEL-1 Enforces Meiotic Crossover Interference (2010) (0)
- Crytsal structure of Wss1 from S. pombe (2016) (0)
- A study by Bellelli et al. entitled POLE3-POLE4 is a histone H3-H4 chaperone that maintains chromatin integrity during DNA replication (2018) (0)
- Proline-specific aminopeptidase P prevents replication-associated genome instability (2022) (0)
- RTEL-1 and DNA polymerase theta promote subtelomeric DNA synthesis and telomere fusion in C. elegans (2022) (0)
- Kerstin Gari Metabolism MMS 19 Links Cytoplasmic Iron-Sulfur Cluster Assembly to DNA (2012) (0)
- New Editor-in-Chief—welcome to Simon Boulton! (2018) (0)
- RTEL Resolves G4/R-Loops to Avert Replication-Transcription Collisions (2020) (0)
- Edinburgh Research Explorer Pol Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis (2018) (0)
- Correction to "Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta". (2023) (0)
- Modulating mutational outcomes and improving precise gene editing at CRISPR-Cas9-induced breaks by chemical inhibition of end-joining pathways. (2023) (0)
- IKK a Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer Graphical (0)
- Direct observation of Shelterin dynamics and T-loop formation at telomeres. (2023) (0)
- Single-Molecule Investigation of Rad-51 Presynaptic Filament Assembly and the Role of Mediator Proteins (2021) (0)
- Erratum: Molecular basis of telomere dysfunction in human genetic diseases (2017) (0)
- Corrigendum: Clinical and Molecular Heterogeneity of RTEL1 Deficiency (2017) (0)
- Negative DNA Supercoiling Induces Genome Wide Cas9 Off-Target Activity (2022) (0)
- Figure 1, [The yeast two-hybrid system.]. (2006) (0)
- The roads to death, DNA damage induced apoptosis in the C. elegans germline (2003) (0)
- Meta-analysis of the amyotrophic lateral sclerosis spectrum uncovers genome instability (2022) (0)
- Higher Than Expected Carrier Frequency Of The Dyskeratosis Congenita RTEL1 p.Arg1264His recessive Founder In Individuals Of Ashkenazi Jewish Ancestry (2013) (0)
- meiotic recombination in yeast Cdc 28 Clb 5 ( CDKS ) and Cdc 7 Dbf 4 ( DDK ) collaborate to initiate data (2008) (0)
- HELQ is a dual-function DSB repair enzyme modulated by RPA and RAD51 (2021) (0)
- SPAR1 is an anti-recombinase that impacts on genome stability and cancer (2008) (0)
- PIH1D1/phospho-Tel2 complex (2014) (0)
- The Role of Fancj in the maintenance of microsatellites and lymphomagenesis (2016) (0)
- Faculty Opinions recommendation of Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair. (2007) (0)
- Indicateur de respiration (2011) (0)
- CDK phosphorylation of TRF2 controls t-loop dynamics during the cell cycle (2019) (0)
- POLQ-1 and HEL-308, the C. elegans members of the mus308 gene family, function in two distinct DNA interstrand cross-link repair pathways (2007) (0)
- Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology (2023) (0)
- Disrupted Control of Origin Activation Promotes Genomic Instability Upon Loss of the Pole4 and Trp53 Tumour Suppressors (2021) (0)
- TRF2-independent chromosome end protection during pluripotency (2020) (0)
- PIH1D1 N-terminal domain (2014) (0)
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