Simone Fulda
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Immunology
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Molecular Biology
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Genetics
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Biology
Simone Fulda's Degrees
- Masters Molecular Biology University of Oxford
- Bachelors Biochemistry University of Oxford
Why Is Simone Fulda Influential?
(Suggest an Edit or Addition)Simone Fulda's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Two CD95 (APO‐1/Fas) signaling pathways (1998) (3290)
- Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 (2018) (3106)
- Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease (2017) (3001)
- Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012) (2913)
- Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012 (2011) (2295)
- Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy (2006) (2141)
- Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes (2009) (2078)
- Targeting mitochondria for cancer therapy (2010) (1422)
- Cellular Stress Responses: Cell Survival and Cell Death (2010) (1152)
- Molecular definitions of autophagy and related processes (2017) (1036)
- Targeting apoptosis pathways in cancer therapy. (2004) (970)
- The landscape of genomic alterations across childhood cancers (2018) (880)
- Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 (2021) (811)
- Essential versus accessory aspects of cell death: recommendations of the NCCD 2015 (2014) (799)
- Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo (2002) (742)
- Targeting IAP proteins for therapeutic intervention in cancer (2012) (620)
- Tumor resistance to apoptosis (2009) (511)
- The CD95 (APO-1/Fas) system mediates drug-induced apoptosis in neuroblastoma cells. (1997) (487)
- Endoplasmic reticulum stress signalling – from basic mechanisms to clinical applications (2018) (436)
- Inhibition of TRAIL-induced apoptosis by Bcl-2 overexpression (2002) (404)
- Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer (2001) (398)
- Activation of Mitochondria and Release of Mitochondrial Apoptogenic Factors by Betulinic Acid* (1998) (365)
- Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors. (1997) (359)
- Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 (2018) (323)
- Betulinic Acid for Cancer Treatment and Prevention (2008) (298)
- cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production (2011) (298)
- Cell death by autophagy: emerging molecular mechanisms and implications for cancer therapy (2015) (279)
- TRAIL induced survival and proliferation in cancer cells resistant towards TRAIL-induced apoptosis mediated by NF-κB (2003) (278)
- Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma (2018) (273)
- IFNγ sensitizes for apoptosis by upregulating caspase-8 expression through the Stat1 pathway (2002) (264)
- Molecular ordering of apoptosis induced by anticancer drugs in neuroblastoma cells. (1998) (260)
- Sensitization for Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Induced Apoptosis by the Chemopreventive Agent Resveratrol (2004) (253)
- Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiency (2015) (241)
- Cytotoxic drugs and the CD95 pathway (1999) (239)
- Cell type specific involvement of death receptor and mitochondrial pathways in drug-induced apoptosis (2001) (239)
- Next-generation personalised medicine for high-risk paediatric cancer patients - The INFORM pilot study. (2016) (237)
- Metabolic inhibitors sensitize for CD95 (APO-1/Fas)-induced apoptosis by down-regulating Fas-associated death domain-like interleukin 1-converting enzyme inhibitory protein expression. (2000) (235)
- Activation of Akt predicts poor outcome in neuroblastoma. (2007) (234)
- Deficient activation of the CD95 (APO-1/Fas) system in drug-resistant cells (1997) (213)
- Resveratrol and derivatives for the prevention and treatment of cancer. (2010) (212)
- Cross-resistance of CD95- and drug-induced apoptosis as a consequence of deficient activation of caspases (ICE/Ced-3 proteases). (1997) (209)
- Sensitization for anticancer drug-induced apoptosis by the chemopreventive agent resveratrol (2004) (202)
- Betulinic acid: A new cytotoxic agent against malignant brain‐tumor cells (1999) (201)
- Modulation of apoptosis by natural products for cancer therapy. (2010) (197)
- Herpes simplex virus thymidine kinase/ganciclovir-induced apoptosis involves ligand-independent death receptor aggregation and activation of caspases. (1999) (191)
- Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner. (2010) (189)
- Targeting mitochondrial apoptosis by betulinic acid in human cancers. (2009) (188)
- Chemosensitivity of solid tumor cells in vitro is related to activation of the CD95 system (1998) (182)
- Obatoclax (GX15-070) triggers necroptosis by promoting the assembly of the necrosome on autophagosomal membranes (2013) (175)
- Caspase-8 in cancer biology and therapy. (2009) (175)
- Targeting apoptosis for anticancer therapy. (2015) (172)
- Reactive oxygen species regulate Smac mimetic/TNFα-induced necroptotic signaling and cell death (2015) (171)
- Evasion of Apoptosis as a Cellular Stress Response in Cancer (2010) (169)
- Small molecule XIAP inhibitors enhance TRAIL-induced apoptosis and antitumor activity in preclinical models of pancreatic carcinoma. (2009) (158)
- Targeting IAP proteins for therapeutic intervention in cancer (2012) (158)
- Targeting XIAP bypasses Bcl-2-mediated resistance to TRAIL and cooperates with TRAIL to suppress pancreatic cancer growth in vitro and in vivo. (2008) (158)
- Role of hypoxia inducible factor-1 alpha in modulation of apoptosis resistance (2007) (153)
- Resveratrol modulation of signal transduction in apoptosis and cell survival: a mini-review. (2006) (149)
- Promises and Challenges of Smac Mimetics as Cancer Therapeutics (2015) (149)
- Phosphatidylinositol 3-kinase inhibition broadly sensitizes glioblastoma cells to death receptor- and drug-induced apoptosis. (2008) (148)
- MycN sensitizes neuroblastoma cells for drug-induced apoptosis (1999) (143)
- Betulinic acid induces apoptosis through a direct effect on mitochondria in neuroectodermal tumors. (2000) (143)
- Betulinic acid-induced apoptosis in leukemia cells (2004) (143)
- Functional CD95 ligand and CD95 death-inducing signaling complex in activation-induced cell death and doxorubicin-induced apoptosis in leukemic T cells. (2000) (138)
- Activation of the CD95 (APO-1/Fas) pathway in drug- and γ-irradiation-induced apoptosis of brain tumor cells (1998) (136)
- Betulinic acid: a natural product with anticancer activity. (2009) (134)
- Betulinic acid as new activator of NF-κB: molecular mechanisms and implications for cancer therapy (2005) (132)
- Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-κB and restricts bacterial proliferation (2017) (120)
- Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute leukemia cells and overcome Bcl-2-mediated resistance. (2008) (117)
- Regulation of TRAIL-induced apoptosis by XIAP in pancreatic carcinoma cells (2007) (115)
- NF-κB regulates DNA double-strand break repair in conjunction with BRCA1–CtIP complexes (2011) (114)
- Smac mimetic and demethylating agents synergistically trigger cell death in acute myeloid leukemia cells and overcome apoptosis resistance by inducing necroptosis (2013) (110)
- 5-Aza-2′-deoxycytidine and IFN-γ cooperate to sensitize for TRAIL-induced apoptosis by upregulating caspase-8 (2006) (106)
- Activation of the hedgehog pathway confers a poor prognosis in embryonal and fusion gene-negative alveolar rhabdomyosarcoma (2010) (106)
- Sensitization for anticancer drug-induced apoptosis by betulinic Acid. (2005) (106)
- Smac mimetic bypasses apoptosis resistance in FADD- or caspase-8-deficient cells by priming for tumor necrosis factor α-induced necroptosis. (2011) (105)
- Apoptosis Signaling in Tumor Therapy (2004) (105)
- Histone acetyltransferase inhibitors block neuroblastoma cell growth in vivo (2015) (103)
- Histone deacetylase inhibitors cooperate with IFN-γ to restore caspase-8 expression and overcome TRAIL resistance in cancers with silencing of caspase-8 (2009) (100)
- MycN and IFNγ cooperate in apoptosis of human neuroblastoma cells (1998) (98)
- Small-Molecule XIAP Inhibitors Enhance γ-Irradiation-Induced Apoptosis in Glioblastoma (2009) (98)
- IAP antagonists: promising candidates for cancer therapy. (2010) (96)
- Impairment of lysosomal integrity by B10, a glycosylated derivative of betulinic acid, leads to lysosomal cell death and converts autophagy into a detrimental process (2012) (94)
- Targeting of XIAP Combined with Systemic Mesenchymal Stem Cell‐Mediated Delivery of sTRAIL Ligand Inhibits Metastatic Growth of Pancreatic Carcinoma Cells (2010) (93)
- Lipoxygenase inhibitors protect acute lymphoblastic leukemia cells from ferroptotic cell death (2017) (93)
- Survivin as a prognostic/predictive marker and molecular target in cancer therapy. (2012) (93)
- PI3K inhibitors prime neuroblastoma cells for chemotherapy by shifting the balance towards pro-apoptotic Bcl-2 proteins and enhanced mitochondrial apoptosis (2011) (92)
- Targeting extrinsic apoptosis in cancer: Challenges and opportunities. (2015) (92)
- The cytotoxic potential of interleukin-15-stimulated cytokine-induced killer cells against leukemia cells. (2012) (92)
- Identification of c-FLIPL and c-FLIPS as critical regulators of death receptor-induced apoptosis in pancreatic cancer cells (2010) (91)
- Induction of CD95 ligand and apoptosis by doxorubicin is modulated by the redox state in chemosensitive- and drug-resistant tumor cells (1999) (90)
- The mechanism of necroptosis in normal and cancer cells (2013) (89)
- Smac mimetic sensitizes glioblastoma cells to Temozolomide-induced apoptosis in a RIP1- and NF-κB-dependent manner (2013) (89)
- Activation of apoptosis pathways in peripheral blood lymphocytes by in vivo chemotherapy. (2001) (88)
- CUX1: target of Akt signalling and mediator of resistance to apoptosis in pancreatic cancer (2010) (87)
- APG350 Induces Superior Clustering of TRAIL Receptors and Shows Therapeutic Antitumor Efficacy Independent of Cross-Linking via Fcγ Receptors (2013) (87)
- Bortezomib Primes Glioblastoma, Including Glioblastoma Stem Cells, for TRAIL by Increasing tBid Stability and Mitochondrial Apoptosis (2011) (86)
- Autophagy in Cancer Therapy (2017) (86)
- HIF-1-Regulated Glucose Metabolism: A Key to Apoptosis Resistance? (2007) (84)
- Differential Induction of Apoptosis and Senescence by the DNA Methyltransferase Inhibitors 5-Azacytidine and 5-Aza-2′-Deoxycytidine in Solid Tumor Cells (2013) (82)
- Identification of a novel proapoptotic function of resveratrol in fat cells: SIRT1‐independent sensitization to TRAIL‐induced apoptosis (2010) (79)
- Apoptosis signaling in cancer stem cells. (2010) (79)
- Therapeutic exploitation of necroptosis for cancer therapy. (2014) (79)
- Molecular Pathways: Targeting Inhibitor of Apoptosis Proteins in Cancer—From Molecular Mechanism to Therapeutic Application (2013) (78)
- Newly identified c-KIT receptor tyrosine kinase ITD in childhood AML induces ligand-independent growth and is responsive to a synergistic effect of imatinib and rapamycin. (2006) (78)
- Pleiotropic effects of sonic hedgehog on muscle satellite cells (2005) (77)
- The PI3K/Akt/mTOR pathway as therapeutic target in neuroblastoma. (2009) (76)
- Cooperation of betulinic acid and TRAIL to induce apoptosis in tumor cells (2004) (76)
- Modulation of TRAIL-induced apoptosis by HDAC inhibitors. (2008) (75)
- The dual PI3K/mTOR inhibitor NVP‐BEZ235 and chloroquine synergize to trigger apoptosis via mitochondrial‐lysosomal cross‐talk (2013) (75)
- TRAIL-Induced Apoptosis Is Preferentially Mediated via TRAIL Receptor 1 in Pancreatic Carcinoma Cells and Profoundly Enhanced by XIAP Inhibitors (2010) (75)
- Histone deacetylase inhibitors sensitize glioblastoma cells to TRAIL-induced apoptosis by c-myc-mediated downregulation of cFLIP (2012) (75)
- The pyridinylfuranopyrimidine inhibitor, PI-103, chemosensitizes glioblastoma cells for apoptosis by inhibiting DNA repair (2009) (75)
- Small-molecule XIAP inhibitors enhance gamma-irradiation-induced apoptosis in glioblastoma. (2009) (74)
- Osteosarcoma cells with genetic signatures of BRCAness are susceptible to the PARP inhibitor talazoparib alone or in combination with chemotherapeutics (2016) (73)
- NF-kappaB inhibition improves the sensitivity of human glioblastoma cells to 5-aminolevulinic acid-based photodynamic therapy. (2011) (72)
- Receptor Proteins in Selective Autophagy (2012) (72)
- Sensitization for gamma-irradiation-induced apoptosis by second mitochondria-derived activator of caspase. (2005) (71)
- Exploiting death receptor signaling pathways for tumor therapy. (2004) (71)
- Resveratrol-mediated sensitisation to TRAIL-induced apoptosis depends on death receptor and mitochondrial signalling. (2005) (71)
- Identification of non-canonical NF-κB signaling as a critical mediator of Smac mimetic-stimulated migration and invasion of glioblastoma cells (2013) (71)
- Smac mimetic primes apoptosis-resistant acute myeloid leukaemia cells for cytarabine-induced cell death by triggering necroptosis. (2014) (70)
- Regulation of necroptosis signaling and cell death by reactive oxygen species (2016) (69)
- Inhibitor of apoptosis proteins as targets for anticancer therapy (2007) (69)
- Smac mimetics as IAP antagonists. (2015) (69)
- Identification of flubendazole as potential anti-neuroblastoma compound in a large cell line screen (2015) (68)
- Targeting Aberrant PI3K/Akt Activation by PI103 Restores Sensitivity to TRAIL-Induced Apoptosis in Neuroblastoma (2011) (68)
- Sensitization of pancreatic carcinoma cells for γ-irradiation-induced apoptosis by XIAP inhibition (2007) (67)
- Oncogenic RAS Mutants Confer Resistance of RMS13 Rhabdomyosarcoma Cells to Oxidative Stress-Induced Ferroptotic Cell Death (2015) (67)
- Identification of a novel pro-apopotic function of NF-κB in the DNA damage response (2009) (67)
- RIP1 is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosis (2012) (67)
- Mitochondria as therapeutic targets for the treatment of malignant disease. (2011) (66)
- Inhibitor of apoptosis proteins in hematological malignancies (2009) (66)
- NF-κB Is Required for Smac Mimetic-Mediated Sensitization of Glioblastoma Cells for γ-Irradiation–Induced Apoptosis (2011) (65)
- Cytotoxic drug-induced, p53-mediated upregulation of caspase-8 in tumor cells (2008) (65)
- RIP1 is required for IAP inhibitor-mediated sensitization for TRAIL-induced apoptosis via a RIP1/FADD/caspase-8 cell death complex (2013) (65)
- A novel paradigm to trigger apoptosis in chronic lymphocytic leukemia. (2009) (64)
- Regulation of apoptosis pathways in cancer stem cells. (2013) (63)
- Apoptosis pathways and their therapeutic exploitation in pancreatic cancer (2009) (63)
- Interference with the HSF1/HSP70/BAG3 Pathway Primes Glioma Cells to Matrix Detachment and BH3 Mimetic–Induced Apoptosis (2016) (61)
- Synthetic lethal interaction between PI3K/Akt/mTOR and Ras/MEK/ERK pathway inhibition in rhabdomyosarcoma. (2013) (61)
- Sorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury (2017) (60)
- AT 101 induces early mitochondrial dysfunction and HMOX1 (heme oxygenase 1) to trigger mitophagic cell death in glioma cells (2018) (59)
- Identification of a novel switch in the dominant forms of cell adhesion-mediated drug resistance in glioblastoma cells (2008) (59)
- Smac mimetic triggers necroptosis in pancreatic carcinoma cells when caspase activation is blocked. (2016) (59)
- Bortezomib Primes Neuroblastoma Cells for TRAIL-Induced Apoptosis by Linking the Death Receptor to the Mitochondrial Pathway (2011) (59)
- Therapeutic exploitation of apoptosis and autophagy for glioblastoma. (2010) (58)
- Smac Mimetics to Therapeutically Target IAP Proteins in Cancer. (2017) (58)
- Apoptotic responsiveness of the Ewing's sarcoma family of tumours to tumour necrosis factor–related apoptosis‐inducing ligand (TRAIL) (2000) (58)
- Adhesion-mediated apoptosis resistance in cancer. (2009) (58)
- Pan-Mammalian Target of Rapamycin (mTOR) Inhibitor AZD8055 Primes Rhabdomyosarcoma Cells for ABT-737-induced Apoptosis by Down-regulating Mcl-1 Protein* (2013) (57)
- Identification of a novel pro-apoptotic role of NF-κB in the regulation of TRAIL- and CD95-mediated apoptosis of glioblastoma cells (2012) (56)
- Modulation of mitochondrial apoptosis by PI3K inhibitors. (2013) (55)
- Resveratrol modulates DNA double-strand break repair pathways in an ATM/ATR-p53- and -Nbs1-dependent manner. (2008) (55)
- PARP Inhibitors Sensitize Ewing Sarcoma Cells to Temozolomide-Induced Apoptosis via the Mitochondrial Pathway (2015) (52)
- Sensitization of neuroblastoma cells for TRAIL‐induced apoptosis by NF‐κB inhibition (2009) (52)
- Death receptor signaling in cancer therapy. (2003) (51)
- G‐Protein coupled receptor 64 promotes invasiveness and metastasis in Ewing sarcomas through PGF and MMP1 (2013) (51)
- Inhibitor of Apoptosis (IAP) proteins in hematological malignancies: molecular mechanisms and therapeutic opportunities (2014) (51)
- Biglycan is a new high-affinity ligand for CD14 in macrophages. (2019) (50)
- MycN and IFNgamma cooperate in apoptosis of human neuroblastoma cells. (1998) (50)
- Identification of synthetic lethality of PLK1 inhibition and microtubule-destabilizing drugs (2015) (50)
- Histone deacetylase inhibitors prime medulloblastoma cells for chemotherapy-induced apoptosis by enhancing p53-dependent Bax activation (2011) (49)
- The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets (2021) (49)
- RSL3 and Erastin differentially regulate redox signaling to promote Smac mimetic-induced cell death (2016) (49)
- Signaling through death receptors in cancer therapy. (2004) (49)
- Betulinic acid: a new chemotherapeutic agent in the treatment of neuroectodermal tumors. (1999) (49)
- Smac mimetic and glucocorticoids synergize to induce apoptosis in childhood ALL by promoting ripoptosome assembly. (2014) (49)
- Identification of DR5 as a critical, NF-κB-regulated mediator of Smac-induced apoptosis (2013) (48)
- Mitochondrial amplification of death signals determines thymidine kinase/ganciclovir-triggered activation of apoptosis. (2000) (48)
- Apoptosis pathways in neuroblastoma therapy. (2003) (48)
- Cell death in hematological tumors (2009) (47)
- USP9X stabilizes XIAP to regulate mitotic cell death and chemoresistance in aggressive B‐cell lymphoma (2016) (46)
- A Bak-dependent mitochondrial amplification step contributes to Smac mimetic/glucocorticoid-induced necroptosis (2016) (46)
- Loss of caspase-8 expression does not correlate with MYCN amplification, aggressive disease, or prognosis in neuroblastoma. (2006) (46)
- Smac mimetic promotes glioblastoma cancer stem-like cell differentiation by activating NF-κB (2014) (46)
- Sequential Dosing in Chemosensitization: Targeting the PI3K/Akt/mTOR Pathway in Neuroblastoma (2013) (46)
- Therapeutic targeting of necroptosis by Smac mimetic bypasses apoptosis resistance in acute myeloid leukemia cells (2017) (45)
- Identification of a novel synthetic lethality of combined inhibition of hedgehog and PI3K signaling in rhabdomyosarcoma (2015) (45)
- Apoptosis in hematological disorders. (2003) (45)
- NF-κB-independent sensitization of glioblastoma cells for TRAIL-induced apoptosis by proteasome inhibition (2007) (45)
- ABT-737 promotes tBid mitochondrial accumulation to enhance TRAIL-induced apoptosis in glioblastoma cells (2012) (45)
- Selective and nonselective toxicity of TRAIL/Apo2L combined with chemotherapy in human bone tumour cells vs. normal human cells (2003) (45)
- Neuroblastoma cells depend on HDAC11 for mitotic cell cycle progression and survival (2017) (44)
- Single-molecule imaging reveals the oligomeric state of functional TNFα-induced plasma membrane TNFR1 clusters in cells (2020) (44)
- Macrophages induce apoptosis in proximal tubule cells (2003) (43)
- Molecular mechanisms of sulfasalazine‐induced T‐cell apoptosis (2002) (43)
- BAG3 induction is required to mitigate proteotoxicity via selective autophagy following inhibition of constitutive protein degradation pathways (2014) (42)
- Targeting c-FLICE-like inhibitory protein (CFLAR) in cancer (2013) (42)
- Ubiquitylation in immune disorders and cancer: from molecular mechanisms to therapeutic implications (2012) (42)
- Inhibition of clonogenic tumor growth: a novel function of Smac contributing to its antitumor activity (2005) (42)
- Identification of a novel synergistic induction of cell death by Smac mimetic and HDAC inhibitors in acute myeloid leukemia cells. (2015) (42)
- Visualizing ubiquitination in mammalian cells (2019) (42)
- ATF4 links ER stress with reticulophagy in glioblastoma cells (2020) (42)
- The role of survivin for radiation oncology: moving beyond apoptosis inhibition. (2011) (41)
- 4-hydroperoxy-cyclophosphamide mediates caspase-independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG (2008) (41)
- RIST: A potent new combination therapy for glioblastoma (2015) (41)
- Targeting X-linked inhibitor of apoptosis protein to increase the efficacy of endoplasmic reticulum stress-induced apoptosis for melanoma therapy. (2010) (40)
- Requirement of nuclear factor κB for Smac mimetic-mediated sensitization of pancreatic carcinoma cells for gemcitabine-induced apoptosis. (2011) (40)
- Targeting inhibitor of apoptosis proteins (IAPs) for cancer therapy. (2008) (40)
- Impairment of antioxidant defense via glutathione depletion sensitizes acute lymphoblastic leukemia cells for Smac mimetic-induced cell death (2014) (39)
- Cathepsin D is released after severe tissue trauma in vivo and is capable of generating C5a in vitro. (2012) (39)
- Histone deacetylase (HDAC) inhibitors and regulation of TRAIL-induced apoptosis. (2012) (39)
- Targeting ferroptosis in rhabdomyosarcoma cells (2020) (39)
- Exploiting mitochondrial apoptosis for the treatment of cancer. (2010) (38)
- Cytotoxic Capacity of IL-15-Stimulated Cytokine-Induced Killer Cells Against Human Acute Myeloid Leukemia and Rhabdomyosarcoma in Humanized Preclinical Mouse Models (2012) (38)
- Cell death-based treatment of glioblastoma (2018) (38)
- Concomitant epigenetic targeting of LSD1 and HDAC synergistically induces mitochondrial apoptosis in rhabdomyosarcoma cells (2017) (37)
- Inhibitor of Apoptosis (IAP) proteins as therapeutic targets for radiosensitization of human cancers. (2012) (37)
- Bortezomib antagonizes microtubule-interfering drug-induced apoptosis by inhibiting G2/M transition and MCL-1 degradation (2013) (37)
- USP22 controls necroptosis by regulating receptor‐interacting protein kinase 3 ubiquitination (2020) (37)
- Small molecule XIAP inhibitors sensitize childhood acute leukemia cells for CD95‐induced apoptosis (2009) (37)
- Variants of the CNTNAP2 5′ promoter as risk factors for autism spectrum disorders: a genetic and functional approach (2014) (36)
- CD95 co-stimulation blocks activation of naive T cells by inhibiting T cell receptor signaling (2009) (36)
- Synergistic interaction of Smac mimetic and IFNα to trigger apoptosis in acute myeloid leukemia cells. (2014) (35)
- Synthetic lethality by co-targeting mitochondrial apoptosis and PI3K/Akt/mTOR signaling. (2014) (35)
- Chloroquine overcomes resistance of lung carcinoma cells to the dual PI3K/mTOR inhibitor PI103 by lysosome-mediated apoptosis (2013) (34)
- Chemosensitization of rhabdomyosarcoma cells by the histone deacetylase inhibitor SAHA. (2014) (34)
- Modulation of TRAIL signaling for cancer therapy. (2004) (34)
- Loperamide, pimozide, and STF-62247 trigger autophagy-dependent cell death in glioblastoma cells (2018) (34)
- Exploiting inhibitor of apoptosis proteins as therapeutic targets in hematological malignancies (2012) (34)
- Smac mimetics and type II interferon synergistically induce necroptosis in various cancer cell lines. (2017) (34)
- The First European Interdisciplinary Ewing Sarcoma Research Summit (2012) (34)
- Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356 (2016) (33)
- Interferons Transcriptionally Up-Regulate MLKL Expression in Cancer Cells1 (2018) (33)
- Critical role of mitochondria-mediated apoptosis for JNJ-26481585-induced antitumor activity in rhabdomyosarcoma (2016) (32)
- In vitro anticancer studies of alpha- and beta-D-glucopyranose betulin anomers. (2010) (32)
- Chemosensitization of glioblastoma cells by the histone deacetylase inhibitor MS275 (2011) (32)
- Regulation of cell migration, invasion and metastasis by IAP proteins and their antagonists. (2014) (32)
- Targeting redox homeostasis in rhabdomyosarcoma cells: GSH-depleting agents enhance auranofin-induced cell death (2017) (32)
- Co-targeting of BET proteins and HDACs as a novel approach to trigger apoptosis in rhabdomyosarcoma cells. (2018) (31)
- Targeting BCL-2 proteins in pediatric cancer: Dual inhibition of BCL-XL and MCL-1 leads to rapid induction of intrinsic apoptosis. (2020) (31)
- Editorial :Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). DOI: 10.1080/15548627.2015.1100356;WOS:000373595400001; 2-s2.0-85013763791&;PMID: 26799652 (2016) (31)
- Regulation of apoptosis through CD95 (APO-I/Fas) receptor-ligand interaction. (1997) (31)
- Deregulated apoptosis signaling in core-binding factor leukemia differentiates clinically relevant, molecular marker-independent subgroups (2011) (31)
- Smac mimetic and oleanolic acid synergize to induce cell death in human hepatocellular carcinoma cells. (2015) (31)
- Tumor-necrosis-factor-related apoptosis-inducing ligand (TRAIL). (2014) (31)
- Diagnostic and clinical relevance of the autophago-lysosomal network in human gliomas (2016) (30)
- Natural killer resistance of a drug-resistant leukemia cell line, mediated by up-regulation of HLA class I expression. (2003) (30)
- Thirty-eight-negative kinase 1 (TNK1) facilitates TNFα-induced apoptosis by blocking NF-κB activation (2007) (30)
- RIP1 Protein-dependent Assembly of a Cytosolic Cell Death Complex Is Required for Inhibitor of Apoptosis (IAP) Inhibitor-mediated Sensitization to Lexatumumab-induced Apoptosis* (2012) (29)
- Identification of IRF1 as critical dual regulator of Smac mimetic-induced apoptosis and inflammatory cytokine response (2014) (29)
- GDC-0941 enhances the lysosomal compartment via TFEB and primes glioblastoma cells to lysosomal membrane permeabilization and cell death. (2013) (29)
- Generation and characterization of ErbB2-CAR-engineered cytokine-induced killer cells for the treatment of high-risk soft tissue sarcoma in children (2017) (29)
- Cell Stress and Cell Death (2010) (29)
- Cell cycle arrest in mitosis promotes interferon-induced necroptosis (2019) (29)
- Cotreatment with Smac mimetics and demethylating agents induces both apoptotic and necroptotic cell death pathways in acute lymphoblastic leukemia cells. (2016) (28)
- Structure-activity studies on N-Substituted tranylcypromine derivatives lead to selective inhibitors of lysine specific demethylase 1 (LSD1) and potent inducers of leukemic cell differentiation. (2018) (28)
- Targeting Apoptosis Signaling Pathways for Anticancer Therapy (2011) (28)
- The SMAC mimetic BV6 sensitizes colorectal cancer cells to ionizing radiation by interfering with DNA repair processes and enhancing apoptosis (2015) (28)
- PI3K Inhibition Enhances Doxorubicin-Induced Apoptosis in Sarcoma Cells (2012) (28)
- Loss of the Chr16p11.2 ASD candidate gene QPRT leads to aberrant neuronal differentiation in the SH-SY5Y neuronal cell model (2018) (28)
- Regulation of tumorigenic Wnt signaling by cyclooxygenase-2, 5-lipoxygenase and their pharmacological inhibitors: A basis for novel drugs targeting cancer cells? (2016) (27)
- Molecular Pathways: Targeting Death Receptors and Smac Mimetics (2014) (27)
- Alternative Cell Death Pathways and Cell Metabolism (2013) (27)
- Smac Mimetic-Induced Upregulation of CCL2/MCP-1 Triggers Migration and Invasion of Glioblastoma Cells and Influences the Tumor Microenvironment in a Paracrine Manner1 (2015) (26)
- Synergistic induction of apoptosis by a polo‐like kinase 1 inhibitor and microtubule‐interfering drugs in Ewing sarcoma cells (2016) (26)
- Pretubulysin: a new option for the treatment of metastatic cancer (2014) (26)
- MycN sensitizes neuroblastoma cells for drug-triggered apoptosis. (2000) (26)
- Targeting inhibitor of apoptosis proteins (IAPs) for diagnosis and treatment of human diseases. (2006) (26)
- A small molecule inhibits protein disulfide isomerase and triggers the chemosensitization of cancer cells. (2014) (25)
- Redox Modulation and Induction of Ferroptosis as a New Therapeutic Strategy in Hepatocellular Carcinoma (2020) (25)
- An introduction to molecular targeted therapy of cancer. (2008) (25)
- Therapeutic opportunities for counteracting apoptosis resistance in childhood leukaemia (2009) (24)
- Antiproliferative potential of cytostatic drugs on neuroblastoma cells in vitro. (1995) (24)
- Eribulin synergizes with Polo-like kinase 1 inhibitors to induce apoptosis in rhabdomyosarcoma. (2015) (23)
- Identification of a novel oxidative stress induced cell death by Sorafenib and oleanolic acid in human hepatocellular carcinoma cells. (2016) (23)
- Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death (2020) (23)
- Side-by-side comparison of BH3-mimetics identifies MCL-1 as a key therapeutic target in AML (2019) (23)
- BCL-2 selective inhibitor ABT-199 primes rhabdomyosarcoma cells to histone deacetylase inhibitor-induced apoptosis (2018) (23)
- Transcriptomic signatures of neuronal differentiation and their association with risk genes for autism spectrum and related neuropsychiatric disorders (2016) (23)
- Role of Smac in cephalostatin-induced cell death (2008) (23)
- Therapeutic opportunities based on caspase modulation. (2017) (23)
- Safety and tolerability of TRAIL receptor agonists in cancer treatment (2015) (23)
- Dual antitumour effect of 5-azacytidine by inducing a breakdown of resistance-mediating factors and epigenetic modulation (2010) (22)
- Modulation of apoptosis signaling for cancer therapy (2006) (22)
- Sorafenib inhibits therapeutic induction of necroptosis in acute leukemia cells (2017) (22)
- Author Correction: The landscape of genomic alterations across childhood cancers (2018) (21)
- TRAIL enhances thymidine kinase/ganciclovir gene therapy of neuroblastoma cells (2002) (21)
- Apoptosis pathways: turned on their heads? (2003) (21)
- Confocal Raman microscopy as a diagnostic tool for investigation of living neuroblastoma tumour cells (2007) (21)
- Identification of RIP1 as a critical mediator of Smac mimetic-mediated sensitization of glioblastoma cells for Drozitumab-induced apoptosis (2015) (21)
- Rocaglamide and a XIAP inhibitor cooperatively sensitize TRAIL‐mediated apoptosis in Hodgkin's lymphomas (2012) (21)
- Shifting the balance of mitochondrial apoptosis: therapeutic perspectives (2012) (21)
- Repurposing anticancer drugs for targeting necroptosis (2018) (21)
- Targeting autophagy for the treatment of cancer (2018) (20)
- Hedgehog Inhibitors in Rhabdomyosarcoma: A Comparison of Four Compounds and Responsiveness of Four Cell Lines (2015) (20)
- Autophagy and cell death (2012) (20)
- Arsenic trioxide induces Noxa-dependent apoptosis in rhabdomyosarcoma cells and synergizes with antimicrotubule drugs. (2016) (19)
- The Smac Mimetic BV6 Improves NK Cell-Mediated Killing of Rhabdomyosarcoma Cells by Simultaneously Targeting Tumor and Effector Cells (2017) (19)
- RIP1 is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosis (2012) (19)
- Specific interactions of BCL-2 family proteins mediate sensitivity to BH3-mimetics in diffuse large B-cell lymphoma (2019) (19)
- BCL-xL-selective BH3 mimetic sensitizes rhabdomyosarcoma cells to chemotherapeutics by activation of the mitochondrial pathway of apoptosis. (2018) (19)
- Targeting apoptosis resistance in rhabdomyosarcoma. (2008) (19)
- NOXA as critical mediator for drug combinations in polychemotherapy (2012) (19)
- Smac mimetic-induced upregulation of interferon-β sensitizes glioblastoma to temozolomide-induced cell death (2015) (18)
- Cell death and survival signaling in oncogenesis. (2010) (18)
- Decreased sensitivity of drug-resistant cells towards T cell cytotoxicity (1999) (18)
- Dose-dependent modulation of apoptotic processes by fluoxetine in maturing neuronal cells: an in vitro study (2011) (18)
- SMAC Mimetic BV6 Enables Sensitization of Resistant Tumor Cells but also Affects Cytokine-Induced Killer (CIK) Cells: A Potential Challenge for Combination Therapy (2014) (18)
- Congenital embryonal rhabdomyosarcoma caused by heterozygous concomitant PTCH1 and PTCH2 germline mutations (2017) (18)
- Cooperative TRAIL production mediates IFNα/Smac mimetic-induced cell death in TNFα-resistant solid cancer cells (2016) (17)
- The pleiotropic profile of the indirubin derivative 6BIO overcomes TRAIL resistance in cancer. (2014) (17)
- Sensitization of acute lymphoblastic leukemia cells for LCL161-induced cell death by targeting redox homeostasis. (2016) (17)
- Cell Death Pathways as Therapeutic Targets in Rhabdomyosarcoma (2012) (16)
- NIK is required for NF-κB-mediated induction of BAG3 upon inhibition of constitutive protein degradation pathways (2015) (16)
- Molecular determinants of apoptosis induced by cytotoxic drugs. (1998) (16)
- Targeting inhibitor of apoptosis proteins by Smac mimetic elicits cell death in poor prognostic subgroups of chronic lymphocytic leukemia (2015) (16)
- The dark side of TRAIL signaling (2013) (16)
- Apoptosis pathways and neuroblastoma therapy. (2009) (15)
- Identification of a synergistic combination of Smac mimetic and Bortezomib to trigger cell death in B-cell non-Hodgkin lymphoma cells. (2017) (15)
- The novel dual BET/HDAC inhibitor TW09 mediates cell death by mitochondrial apoptosis in rhabdomyosarcoma cells. (2020) (15)
- JNJ-26481585 primes rhabdomyosarcoma cells for chemotherapeutics by engaging the mitochondrial pathway of apoptosis (2015) (15)
- Novel insights into the synergistic interaction of Bortezomib and TRAIL: tBid provides the link (2011) (15)
- Inhibitor of apoptosis (IAP) proteins: novel insights into the cancer-relevant targets for cell death induction. (2009) (14)
- The long non-coding RNA HOTAIRM1 promotes tumor aggressiveness and radiotherapy resistance in glioblastoma (2021) (14)
- Targeting IAP proteins in combination with radiotherapy (2015) (14)
- Regulation of cell death in cancer—possible implications for immunotherapy (2012) (14)
- Targeting inhibitor of apoptosis proteins for cancer therapy: a double-edge sword? (2014) (14)
- Smac mimetic suppresses tunicamycin-induced apoptosis via resolution of ER stress (2019) (14)
- NRAS-Mutated Rhabdomyosarcoma Cells Are Vulnerable to Mitochondrial Apoptosis Induced by Coinhibition of MEK and PI3Kα. (2018) (14)
- DNA damage response involves modulation of Ku70 and Rb functions by cyclin A1 in leukemia cells (2007) (14)
- Smac mimetic induces cell death in a large proportion of primary acute myeloid leukemia samples, which correlates with defined molecular markers (2016) (14)
- Selected Secondary Plant Metabolites for Cancer Therapy (2015) (13)
- HDAC inhibitors: Double edge sword for TRAIL cancer therapy? (2005) (13)
- Suberoylanilide hydroxamic acid synergistically enhances the antitumor activity of etoposide in Ewing sarcoma cell lines (2015) (13)
- Effects of WR-2721 (amifostine) and its metabolite WR-1065 on the antiproliferative activity of chemotherapeutic agents on neuroblastoma cells in vitro (1997) (13)
- A direct comparison of selective BH3-mimetics reveals BCL-XL, BCL-2 and MCL-1 as promising therapeutic targets in neuroblastoma (2020) (13)
- Thirty-eight-negative kinase 1 (TNK1) facilitates TNFalpha-induced apoptosis by blocking NF-kappaB activation. (2007) (13)
- Exploiting apoptosis pathways for the treatment of pediatric cancers (2009) (12)
- Smac mimetic induces an early wave of gene expression via NF-κB and AP-1 and a second wave via TNFR1 signaling. (2018) (12)
- Caspase Activation in Cancer Therapy (2013) (12)
- Polo-like kinase 1 inhibition sensitizes neuroblastoma cells for vinca alkaloid-induced apoptosis (2015) (11)
- Different Response of Ptch Mutant and Ptch Wildtype Rhabdomyosarcoma Toward SMO and PI3K Inhibitors (2018) (11)
- Genetic deletion of Nox4 enhances cancerogen-induced formation of solid tumors (2021) (11)
- Hypoxia Enhances the Antiglioma Cytotoxicity of B10, a Glycosylated Derivative of Betulinic Acid (2014) (11)
- Regulation of cell death and survival by resveratrol: implications for cancer therapy. (2012) (11)
- Acute lymphoblastic leukemia cells treated with CpG oligodeoxynucleotides, IL-4 and CD40 ligand facilitate enhanced anti-leukemic CTL responses (2011) (11)
- Molecular features of the cytotoxicity of an NHE inhibitor: Evidence of mitochondrial alterations, ROS overproduction and DNA damage (2016) (11)
- Targeting Apoptosis Signaling in Pancreatic Cancer (2011) (11)
- Combined Inhibition of Epigenetic Readers and Transcription Initiation Targets the EWS-ETS Transcriptional Program in Ewing Sarcoma (2020) (10)
- Inhibitor of Apoptosis Proteins in Pediatric Leukemia: Molecular Pathways and Novel Approaches to Therapy (2013) (10)
- Dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 synergizes with chloroquine to induce apoptosis in embryonal rhabdomyosarcoma. (2015) (10)
- Quantitative single‐molecule imaging of TNFR1 reveals zafirlukast as antagonist of TNFR1 clustering and TNFα‐induced NF‐ĸB signaling (2020) (10)
- Targeting apoptosis pathways in childhood malignancies. (2013) (10)
- TNF-related Apoptosis-inducing Ligand (TRAIL) (2010) (10)
- Mitochondria: The Anti- cancer Target for the Third Millennium (2014) (10)
- A Perspective on Polo-Like Kinase-1 Inhibition for the Treatment of Rhabdomyosarcomas (2019) (10)
- Absence of FLICE-Inhibitory Protein Is a Novel Independent Prognostic Marker for Very Short Survival in Pancreatic Ductal Adenocarcinoma (2013) (9)
- Mouse lung fibroblasts are highly susceptible to necroptosis in a reactive oxygen species‐dependent manner (2018) (9)
- Manatee invariants reveal functional pathways in signaling networks (2017) (9)
- Smac mimetic sensitizes renal cell carcinoma cells to interferon-α-induced apoptosis. (2016) (9)
- The IRE1 and PERK arms of the unfolded protein response promote survival of rhabdomyosarcoma cells. (2020) (9)
- Differential role of RIP1 in Smac mimetic-mediated chemosensitization of neuroblastoma cells (2015) (9)
- Cotreatment with sorafenib and oleanolic acid induces reactive oxygen species-dependent and mitochondrial-mediated apoptotic cell death in hepatocellular carcinoma cells (2019) (9)
- Co-inhibition of BET proteins and PI3Kα triggers mitochondrial apoptosis in rhabdomyosarcoma cells (2020) (8)
- Thioredoxin inhibitor PX-12 induces mitochondria-mediated apoptosis in acute lymphoblastic leukemia cells (2019) (8)
- Organelle-specific mechanisms of drug-induced autophagy-dependent cell death. (2020) (8)
- Identification of Smac mimetics as novel substrates for p-glycoprotein. (2019) (8)
- How to target apoptosis signaling pathways for the treatment of pediatric cancers (2013) (8)
- Next-generation hypomethylating agent SGI-110 primes acute myeloid leukemia cells to IAP antagonist by activating extrinsic and intrinsic apoptosis pathways (2019) (7)
- Novel promising IAP antagonist on the horizon for clinical translation. (2012) (7)
- USP 9 X stabilizes XIAP to regulate mitotic cell death and chemoresistance in aggressive B-cell lymphoma (2016) (7)
- Selective BH3-mimetics targeting BCL-2, BCL-XL or MCL-1 induce severe mitochondrial perturbations (2018) (7)
- Eribulin alone or in combination with the PLK1 inhibitor BI 6727 triggers intrinsic apoptosis in Ewing sarcoma cell lines. (2017) (7)
- Reactive oxygen species contribute toward Smac mimetic/temozolomide-induced cell death in glioblastoma cells (2016) (7)
- Histone deacetylase inhibitors sensitize glioblastoma cells to TRAIL-induced apoptosis by c-myc- mediated downregulation of cFLIP (2012) (7)
- Cross talk between cell death regulation and metabolism. (2014) (6)
- Differential involvement of TAK1, RIPK1 and NF-κB signaling in Smac mimetic-induced cell death in breast cancer cells (2018) (6)
- Deficient Activation of Caspases ( ICE / Ced-3 Proteases ) Cross-Resistance of CD 95-and Drug-Induced Apoptosis as a Consequence (1997) (6)
- ATM inhibition enhances Auranofin-induced oxidative stress and cell death in lung cell lines (2020) (6)
- Proteasome inhibitors and Smac mimetics cooperate to induce cell death in diffuse large B‐cell lymphoma by stabilizing NOXA and triggering mitochondrial apoptosis (2020) (6)
- STF-62247 and pimozide induce autophagy and autophagic cell death in mouse embryonic fibroblasts (2020) (5)
- Inflammation, Regeneration, and Transformation in the Pancreas: Results of the Collaborative Research Center 518 (SFB 518) at the University of Ulm (2011) (5)
- Smac mimetics and TRAIL cooperate to induce MLKL-dependent necroptosis in Burkitt's lymphoma cell lines (2021) (5)
- Hedgehog signaling negatively co-regulates BH3-only protein Noxa and TAp73 in TP53-mutated cells. (2018) (5)
- CD 95 co-stimulation blocks activation of naive T cells by inhibiting T cell receptor signaling (2009) (5)
- Apoptosis and cancer therapy : from cutting-edge science to novel therapeutic concepts (2006) (5)
- Preclinical and clinical aspects on the use of amifostine as chemoprotectorin neuroblastoma patients (2001) (5)
- Rhabdomyosarcoma cells are susceptible to cell death by LDK378 alone or in combination with sorafenib independently of anaplastic lymphoma kinase status (2017) (5)
- Mitochondria, redox signaling and cell death in cancer (2016) (4)
- Next‐generation sequencing reveals a novel role of lysine‐specific demethylase 1 in adhesion of rhabdomyosarcoma cells (2019) (4)
- Apoptosis and Cancer Therapy (2006) (4)
- Concomitant targeting of Hedgehog signaling and MCL-1 synergistically induces cell death in Hedgehog-driven cancer cells. (2019) (4)
- Molecular Targeted Therapies for Rhabdomyosarcoma: Focus on Hedgehog and Apoptosis Signaling (2013) (4)
- Obatoclax (GX15-070) triggers necroptosis by promoting the assembly of the necrosome on autophagosomal membranes (2014) (3)
- Signal transduction therapy targeting apoptosis pathways in cancers (2006) (3)
- Abstract 5250: PI3K inhibitors prime neuroblastoma cells for chemotherapy-induced apoptosis apoptosis in vitro and in vivo by shifting the balance towards pro-apoptotic Bcl-2 proteins and increased mitochondrial perturbations (2010) (3)
- NF-κB contributes to Smac mimetic-conferred protection from tunicamycin-induced apoptosis (2019) (3)
- Eribulin alone or in combination with the PLK1 inhibitor BI 6727 triggers intrinsic apoptosis in Ewing sarcoma cell lines (2017) (3)
- Smac agonists sensitize for TRAIL - or anticancer drug-induced apoptosis (2002) (3)
- The landscape of genomic alterations across childhood cancers (2018) (3)
- 267 POSTER Small molecule XIAP inhibitors enhance TRAIL- or anticancer drug-induced apoptosis in childhood acute leukemia cells and overcome Bcl-2-mediated resistance (2008) (3)
- ESF-EMBO Symposium “Molecular Biology and Innovative Therapies in Sarcomas of Childhood and Adolescence” Sept 29–Oct 4, Polonia Castle Pultusk, Poland (2013) (3)
- Therapeutic Modulation of Apoptosis in Cancer Therapy (2008) (2)
- Apoptotic Cell Clearance by Macrophages: Relevance to Tumor Pathogenesis (2006) (2)
- HIF-1-regulated glucose metabolism in the control of apoptosis signaling (2008) (2)
- CD95 (APO-1/Fas)- and p53-independent apoptosis by betulinic acid involves mitochondrial alterations and activation of caspases. (1997) (2)
- Mathematical modeling of the molecular switch of TNFR1-mediated signaling pathways applying Petri net formalism and in silico knockout analysis (2022) (2)
- Confocal Raman microscopy for investigation of the level of differentiation in living neuroblastoma tumor cells (2007) (2)
- Regulation of the antiapoptotic protein cFLIP by the glucocorticoid Dexamethasone in ALL cells (2018) (2)
- Caspase-8 and Cancer (2011) (2)
- Preclinical and clinical aspects on the use of amifostine as chemoprotector in neuroblastoma patients. (2001) (2)
- More (on) prognostic factors in chronic lymphocytic leukemia (2010) (2)
- PO-433 The modulation of redox homeostasis and induction of ferroptotic cell death in hepatocellular carcinoma as an anticancer strategy (2018) (1)
- Hereditary Tumors in Children (2009) (1)
- Therapeutic modulation of death receptor- or drug-mediated apoptosis (2002) (1)
- NF-κB contributes to Smac mimetic-conferred protection from tunicamycin-induced apoptosis (2019) (1)
- Editorial: Cell stress and cell death (2010) (1)
- Exploiting Apoptosis Pathways for the Treatment of Pancreatic Cancer (2009) (1)
- Biomarker of sensitivity to PR-104 in leukemia. (2015) (1)
- Deregulated Apoptotic Pathways Point to Effectiveness of IAP Inhibitor Therapy in Acute Myeloid Leukemia. (2009) (1)
- TRAIL and cancer therapy (2009) (1)
- Sensitization for γ-Irradiation-Induced Apoptosis by Smac. (2004) (1)
- NF-kappaB inhibition improves the sensitivity of human glioblastoma cells to 5-aminolevulinic acid-based photodynamic therapy (2011) (1)
- Abstract CN04-04: Targeting death receptors and SMAC mimetics. (2013) (1)
- Editorial: Biology-Driven Targeted Therapy of Pediatric Soft-Tissue and Bone Tumors: Current Opportunities and Future Challenges (2016) (1)
- Apoptotic Cells induce Proliferation of Peritoneal Macrophages (2021) (1)
- Mathematical modeling of the molecular switch of TNFR1-mediated signaling pathways using Petri nets (2021) (1)
- Radiosensitization of Human Cancers by Smac Agonists. (2005) (1)
- Death Receptor Pathways As Targets for Anticancer Therapy (2005) (1)
- 39: Autophagy and cell death (2014) (1)
- Molecular Targeted Therapy (2009) (1)
- Regulation of cancer stem-like cell differentiation by Smac mimetics (2014) (1)
- Regulation of Apoptosis and Cell Survival by Resveratrol (2010) (1)
- Combination of Chemotherapy and Death Ligands in Cancer Therapy (2005) (1)
- Inhibiting the PI3K/Akt/mTOR pathway in combination with conventional chemotherapy as a new treatment option for GBM patients (2010) (0)
- First EACR Conference on Cell Death in Cancer, Amsterdam, Netherlands, 26–28 January 2012 (2012) (0)
- Epigenetic silencing of caspase-8: A novel mechanism of drug resistance which can be overcome by demethylating agents, histone deacetylase inhibitors, IFN gamma or caspase-8 gene transfer (2002) (0)
- STF-62247 and pimozide induce autophagy and autophagic cell death in mouse embryonic fibroblasts (2020) (0)
- Targeting Apoptosis Pathways for the Treatment of Pediatric Cancers (2011) (0)
- Experimental Therapeutics , Molecular Targets , and Chemical Biology A Novel Paradigm to Trigger Apoptosis in Chronic Lymphocytic Leukemia (2009) (0)
- Small molecule XIAP inhibitors sensitize childhood acute leukemia cells for apoptosis induction and break Bcl-2-mediated resistance (2010) (0)
- Abstract 4341: Bortezomib primes neuroblastoma cells for TRAIL- triggered apoptosis by linking the death receptor to the mitochondrial pathway (2011) (0)
- Role of PI3K Inhibitors in Sensitizing Neuroblastoma Cells to Apoptosis (2013) (0)
- University of Birmingham A perspective on polo-like kinase-1 inhibition for the treatment of rhabdomyosarcoma (2019) (0)
- 1 NF-κ B is required for Smac mimetic-mediated sensitization of glioblastoma cells for γ-irradiation-induced apoptosis 1 (2011) (0)
- Mechanisms of Deregulation of Apoptosis in Myeloma (2019) (0)
- Abstract PR13: Targeting p-TEFb as well as the EWS-ETS-specific transcriptional program in Ewing sarcoma synergistically blocks tumor growth (2018) (0)
- The chemopreventive substance resveratrol induces fidelity control mechanisms of DNA double-strand break repair via activation of ATM-p53 and ATM/ATR-Nbs1 pathways (2007) (0)
- Antileukemic Treatment Targeted at Apoptosis Regulators (2019) (0)
- Abstract 2911: Small molecule XIAP inhibitors sensitize acute leukemia cells for TRAIL- or chemotherapy-induced apoptosis, overcome Bcl-2-mediated resistance and reduce leukemic burden in vivo in NOD/SCID mice (2010) (0)
- 2.O.05 TRANSLATIONAL SARCOMA RESEARCH NETWORK (TRANSARNET) (2010) (0)
- Modulation of apoptosis signalling for cancer therapy (2006) (0)
- Cell cycle arrest in mitosis promotes interferon-induced necroptosis (2019) (0)
- Leading Edge Primer Ferroptosis : A Regulated Cell Death Nexus Linking Metabolism , Redox Biology , and Disease (2017) (0)
- 259 POSTER Histone deacetylase inhibitors restore caspase-8 expression and overcome TRAIL resistance in cancers with epigenetic silencing of caspase-8 (2008) (0)
- Cell death-based treatment of glioblastoma (2018) (0)
- Second EACR Conference on Cell Death in Cancer, Amsterdam, The Netherlands, 30 January–1 February 2014 (2014) (0)
- Abstract 5119: Smac mimetic inhibits tumorigenicity and growth of glioblastoma by promoting differentiation of glioblastoma cancer stem-like cells (2014) (0)
- Apoptosis Induced by Extracts of Helleborus Niger in Different Lymphoma and Leukemia Cell Lines and Primary Lymphoblasts of Children with ALL Is Independent of Smac-Overexpression and Executed Via the Mitochondrial Pathway. (2007) (0)
- 354 INVITED Apoptosis Research in Paediatric Malignancies – New Targets for Therapy (2011) (0)
- Abstract 4508: Targeting XIAP as a novel paradigm to induce apoptosis in chronic lymphocytic leukemia (2010) (0)
- Abstract 5343: Aberrant activation of hedgehog signaling confers a poor prognosis in embryonal and fusion gene negative alveolar rhabdomyosarcoma (2011) (0)
- 230 POSTER PI3 Kinase inhibitors broadly sensitize glioblastoma cells for death receptor- or chemotherapy-induced apoptosis (2008) (0)
- Inhibition of NF-kappa B and induction of apoptosis by sulphasalazine (2002) (0)
- Cell Death in Cancer and Cancer Therapy (2005) (0)
- Strategies to Overcome TRAIL Resistance in Cancer (2013) (0)
- Targeting Cell Death Pathways in Neuroblastoma (2015) (0)
- Preclinical Development NFk B Is Required for SmacMimetic-Mediated Sensitization of Glioblastoma Cells for g-Irradiation – Induced Apoptosis (2011) (0)
- Abstract 4692: IAP inhibitors prime childhood leukemia cells to chemotherapy-induced apoptosis in a strictly RIP1-dependent manner and exert anti-leukemic activity in a NOD/SCID mouse model in vivo (2011) (0)
- Betulinic acid derivatives for treatment of neuroectodermal tumors (1999) (0)
- Genes Involved in Apoptosis Regulation: Implications for Cancer Therapy (2005) (0)
- Harnessing Death Receptor Signaling for Cancer Treatment (2013) (0)
- Abstract B81: Analogues of the chromenone namoline as inhibitors of lysine specific demethylase 1 (LSD1) (2015) (0)
- Next-generation hypomethylating agent SGI-110 primes acute myeloid leukemia cells to IAP antagonist by activating extrinsic and intrinsic apoptosis pathways (2019) (0)
- Identification of a novel proapoptotic function of resveratrol in fat cells: SIRT1-independent sensitization to TRAIL-induced apoptosis (2010) (0)
- Loperamide, pimozide, and STF-62247 trigger autophagy-dependent cell death in glioblastoma cells (2018) (0)
- Resveratrol as Inhibitor of Cell Survival Signal Transduction (2005) (0)
- GSE62533: Inhibitor of apoptosis proteins as promising therapeutic targets in chronic lymphocytic leukemia (2015) (0)
- 228 POSTER Identification and evaluation of PI3 Kinase as new molecular target in neuroblastoma that critically regulates apoptosis resistance (2008) (0)
- MCP-1 – a critical inducer of Smac mimetic-induced migration and invasion in glioma cells (2014) (0)
- XIAP to regulate mitotic cell death and chemoresistance in aggressive B-cell lymphoma (2016) (0)
- XIAP Inhibitors Present a Promising New Strategy to Sensitize Childhood Acute Leukemia Cells for Chemotherapy-Induced Apoptosis. (2009) (0)
- Targeting IAP proteins in combination with radiotherapy (2015) (0)
- Correction: Smac mimetic suppresses tunicamycin-induced apoptosis via resolution of ER stress (2019) (0)
- Targeting XIAP to increase endoplasmic reticulum stress-induced apoptosis of malignant melanoma (2009) (0)
- Molecular features of the cytotoxicity of an NHE inhibitor: Evidence of mitochondrial alterations, ROS overproduction and DNA damage (2016) (0)
- Abstract SY24-03: Targeting IAP proteins in cancer: From molecular mechanism to therapeutic application. (2013) (0)
- Bypassing Cancer Resistance by Antagonizing “Inhibitor of Apoptosis Proteins” (IAPs) (2008) (0)
- Redox regulation of Smac mimetic-induced cell death (2015) (0)
- Targeting XIAP overcomes apoptosis resistance of pancreatic carcinoma cells in vitro and suppresses tumor growth and invasion in vivo (2006) (0)
- Activation of Acute Lymphocytic Leukemia Blasts with CpG ODN, IL-4 and CD40 Ligand Facilitates Enhanced Anti-Leukemic CTL Responses (2010) (0)
- CCL2 – a critical inducer of Smac mimetic-induced migration and invasion in glioblastoma cells and its impact on the tumor microenvironment (2015) (0)
- The SMAC mimetic BV6 sensitizes colorectal cancer cells to ionizing radiation by interfering with DNA repair processes and enhancing apoptosis (2015) (0)
- Bcl-2 overexpression inhibits TRAIL-induced apoptosis in type II cells (2002) (0)
- Exploiting Resveratrol for the Treatment of Cancer (2012) (0)
- Featuring the guest editor (2013) (0)
- Abstract 3480: XIAP inhibitors prime glioblastoma cells for γ-irradiation-induced apoptosis and circumvent radioresistance of glioblastoma stem cells (2010) (0)
- IAPs and Resistance to Death Receptors in Cancer (2017) (0)
- REVIEW Cytotoxic drugs and the CD95 pathway (1999) (0)
- Smac mimetics cooperate with STING to induce necroptosis in apoptosis-resistant pancreatic carcinoma cells (2021) (0)
- Apoptosis in Cancer Biology and Cancer Therapeutics (2009) (0)
- Exploitation of Apoptosis Pathways for Childhood Leukemia (2011) (0)
- 260 POSTER A novel paradigm for apoptosis-based therapy of pancreatic cancer: sensitizer/inducer concept of XIAP inhibitors combined with TRAIL (2008) (0)
- Congenital embryonal rhabdomyosarcoma caused by heterozygous concomitant PTCH1 and PTCH2 germline mutations (2017) (0)
- Targeting IAP Proteins to Sensitize Childhood Acute Leukemia Cells for Apoptosis (2011) (0)
- Abstract #2781: XIAP inhibitors prime childhood acute leukemia cells for TRAIL-induced apoptosis, overcome Bcl-2-mediated resistance and exert anti-leukemic activity in a NOD/SCID mouse model of childhood acute leukemia (2009) (0)
- Safety and tolerability of TRAIL receptor agonists in cancer treatment (2015) (0)
- Abstract 2278: Smac mimetic primes FADD- or caspase-8-deficient leukemia cells for TNFα-induced necroptosis and overcomes apoptosis resistance (2012) (0)
- leukemic T cells activation-induced cell death and doxorubicin-induced apoptosis in Functional CD 95 ligand and CD 95 death-inducing signaling complex in (1999) (0)
- PO-433 The modulation of redox homeostasis and induction of ferroptotic cell death in hepatocellular carcinoma as an anticancer strategy (2018) (0)
- Enhancing Cytotoxicity of Cytokine-Induced Killer (CIK) Cells against Refractory Leukemia (2011) (0)
- Abstract PR-8: XIAP inhibitors prime acute leukemia cells for TRAIL‐ or chemotherapy‐induced apoptosis, bypass Bcl‐2‐imposed resistance and exert antileukemic activity in a NOD/SCID mouse model of pediatric acute leukemia (2009) (0)
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What Schools Are Affiliated With Simone Fulda?
Simone Fulda is affiliated with the following schools:
