Snorri S. Thorgeirsson

Snorri S. Thorgeirsson's AcademicInfluence.com Rankings

Philosophy

#3463

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#5597

Historical Rank

Logic

#1173

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#1856

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philosophy Degrees

Snorri S. Thorgeirsson

Biology

#4334

World Rank

#6476

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Molecular Biology

#331

World Rank

#336

Historical Rank

biology Degrees

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Philosophy
Biology

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Snorri S. Thorgeirsson's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Molecular pathogenesis of human hepatocellular carcinoma (2002) (1556)
Acetaminophen-Induced Hepatic Necrosis (1974) (1479)
A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells (2006) (896)
Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling (2004) (816)
A unique metastasis gene signature enables prediction of tumor relapse in early-stage hepatocellular carcinoma patients. (2010) (755)
Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties (2009) (700)
Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair. (2004) (695)
Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions. (1995) (691)
Ubiquitous activation of Ras and Jak/Stat pathways in human HCC. (2006) (680)
Acetaminophen‐induced hepatic injury: Protective role of glutathione in man and rationale for therapy (1974) (485)
A precursor-product relationship exists between oval cells and hepatocytes in rat liver. (1987) (463)
Application of comparative functional genomics to identify best-fit mouse models to study human cancer (2004) (458)
Transgenic mice with increased plasma levels of TGF-beta 1 develop progressive renal disease. (1996) (449)
Genomic and genetic characterization of cholangiocarcinoma identifies therapeutic targets for tyrosine kinase inhibitors. (2012) (437)
Mechanistic and prognostic significance of aberrant methylation in the molecular pathogenesis of human hepatocellular carcinoma. (2007) (375)
Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype. (2006) (370)
Mutations in Isocitrate Dehydrogenase 1 and 2 Occur Frequently in Intrahepatic Cholangiocarcinomas and Share Hypermethylation Targets with Glioblastomas (2012) (345)
Cellular distribution of transforming growth factor-beta 1 and procollagen types I, III, and IV transcripts in carbon tetrachloride-induced rat liver fibrosis. (1990) (344)
In vivo differentiation of rat liver oval cells into hepatocytes. (1989) (330)
Hepatic stem cells in liver regeneration (1996) (320)
Transforming growth factor‐β gene expression signature in mouse hepatocytes predicts clinical outcome in human cancer (2008) (305)
Expression of stem cell factor and its receptor, c-kit, during liver regeneration from putative stem cells in adult rat. (1994) (295)
Origin and structural evolution of the early proliferating oval cells in rat liver. (2001) (292)
Integrative genomic identification of genes on 8p associated with hepatocellular carcinoma progression and patient survival. (2012) (290)
Acetaminophen-induced hepatic necrosis. V. Correlation of hepatic necrosis, covalent binding and glutathione depletion in hamsters. (1974) (288)
Expression of the multidrug-resistant gene in hepatocarcinogenesis and regenerating rat liver. (1987) (259)
Common Molecular Subtypes Among Asian Hepatocellular Carcinoma and Cholangiocarcinoma. (2017) (256)
Tissue inhibitor of metalloproteinases‐1 promotes liver fibrosis development in a transgenic mouse model (2000) (254)
Functional and genetic deconstruction of the cellular origin in liver cancer (2015) (248)
Targeting the mTOR pathway in hepatocellular carcinoma: current state and future trends. (2014) (246)
Expression of hepatic transcription factors during liver development and oval cell differentiation (1994) (243)
Differential effects of transforming growth factor-beta on proliferation of normal and malignant rat liver epithelial cells in culture. (1986) (238)
Hematopoietic cells as hepatocyte stem cells: A critical review of the evidence (2006) (236)
Carcinogenicity of 2‐Amino‐3‐methylimidazo[4,5‐f]quinoline in Nonhuman Primates: Induction of Tumors in Three Macaques (1990) (229)
Dominant role of hepatitis B virus and cofactor role of aflatoxin in hepatocarcinogenesis in Qidong, China (2002) (225)
Cyclin G recruits PP2A to dephosphorylate Mdm2. (2002) (219)
GTF2IRD1 in Craniofacial Development of Humans and Mice (2005) (213)
Atypical ductular proliferation and its inhibition by transforming growth factor beta1 in the 3,5-diethoxycarbonyl-1,4-dihydrocollidine mouse model for chronic alcoholic liver disease. (1999) (207)
Transcriptomic profiling reveals hepatic stem‐like gene signatures and interplay of miR‐200c and epithelial‐mesenchymal transition in intrahepatic cholangiocarcinoma (2012) (206)
Transgenic Mouse Model for Synergistic Effects of Nuclear Oncogenes and Growth Factors in Tumorigenesis: Interaction of c-myc and Transforming Growth Factor α in Hepatic Oncogenesis (1993) (205)
Curcumin effectively inhibits oncogenic NF-κB signaling and restrains stemness features in liver cancer. (2015) (205)
DLC-1:a Rho GTPase-activating protein and tumour suppressor (2007) (203)
Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway (2011) (201)
The Ah locus and the metabolism of chemical carcinogens and other foreign compounds. (1977) (200)
Occurrence of oval‐type cells in hepatitis B virus—associated human hepatocarcinogenesis (1992) (198)
Sulfatase 2 up‐regulates glypican 3, promotes fibroblast growth factor signaling, and decreases survival in hepatocellular carcinoma (2008) (186)
The Fn14 immediate-early response gene is induced during liver regeneration and highly expressed in both human and murine hepatocellular carcinomas. (2000) (184)
Identification of a cholangiocarcinoma-like gene expression trait in hepatocellular carcinoma. (2010) (177)
Origin and fate of oval cells in dipin-induced hepatocarcinogenesis in the mouse. (1994) (176)
Hepatocyte-stellate cell cross-talk in the liver engenders a permissive inflammatory microenvironment that drives progression in hepatocellular carcinoma. (2012) (175)
Central role of c-Myc during malignant conversion in human hepatocarcinogenesis. (2009) (173)
Genome-scale profiling of gene expression in hepatocellular carcinoma: classification, survival prediction, and identification of therapeutic targets. (2004) (172)
DLC-1 gene inhibits human breast cancer cell growth and in vivo tumorigenicity (2003) (168)
Expression of hepatocyte growth factor and c-met genes during hepatic differentiation and liver development in the rat. (1993) (167)
Hepatocyte growth factor/c‐met signaling is required for stem‐cell–mediated liver regeneration in mice (2012) (165)
Disruption of Redox Homeostasis in the Transforming Growth Factor-α/c-myc Transgenic Mouse Model of Accelerated Hepatocarcinogenesis* (1998) (163)
DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas (2004) (158)
Dual functions of E2F-1 in a transgenic mouse model of liver carcinogenesis (2000) (154)
Ontogenetic expression of polycyclic aromatic compound-inducible monooxygenase activities and forms of cytochrome P-450 in rabbit. Evidence for temporal control and organ specificity of two genetic regulatory systems. (1977) (153)
Modeling pathogenesis of primary liver cancer in lineage-specific mouse cell types. (2013) (153)
Acetaminophen-induced hepatic necrosis. VI. Metabolic disposition of toxic and nontoxic doses of acetaminophen. (1974) (149)
The recombinant proregion of transforming growth factor beta1 (latency-associated peptide) inhibits active transforming growth factor beta1 in transgenic mice. (1996) (149)
Transforming growth factor-beta 1 and type I procollagen transcripts during regeneration and early fibrosis of rat liver. (1990) (147)
Signal transducer and activator of transcription 3‐mediated CD133 up‐regulation contributes to promotion of hepatocellular carcinoma (2015) (146)
Restoration of DLC-1 gene expression induces apoptosis and inhibits both cell growth and tumorigenicity in human hepatocellular carcinoma cells (2004) (146)
SMOKING AND INDUSTRIAL POLLUTION, AND THEIR EFFECTS ON MENOPAUSE AND OVARIAN CANCER (1978) (145)
Transient activation of NF-κB through a TAK1/IKK kinase pathway by TGF-β1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formation (2003) (145)
Gene Expression–Based Recurrence Prediction of Hepatitis B Virus–Related Human Hepatocellular Carcinoma (2008) (144)
Hepatic precursors derived from murine embryonic stem cells contribute to regeneration of injured liver (2006) (144)
Functional genomics of hepatocellular carcinoma (2006) (139)
Induction of mammary tumors in female Sprague-Dawley rats by the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and effect of dietary fat. (1994) (138)
Inactivation of Ras GTPase-activating proteins promotes unrestrained activity of wild-type Ras in human liver cancer. (2011) (138)
Alterations of tumor suppressor genes and allelic losses in human hepatocellular carcinomas in China. (1994) (136)
Sirtuin‐6–dependent genetic and epigenetic alterations are associated with poor clinical outcome in hepatocellular carcinoma patients (2013) (135)
Analysis of transforming growth factor (TGF)-alpha/epidermal growth factor receptor, hepatocyte growth Factor/c-met,TGF-beta receptor type II, and p53 expression in human hepatocellular carcinomas. (1997) (134)
Contribution of CYP1A1 and CYP1A2 to the activation of heterocyclic amines in monkeys and human. (1994) (131)
Engrafted human stem cell-derived hepatocytes establish an infectious HCV murine model. (2014) (131)
Disruption of the pRb/E2F pathway and inhibition of apoptosis are major oncogenic events in liver constitutively expressing c-myc and transforming growth factor alpha. (1998) (131)
Activation of hepatic stem cell compartment in the rat: role of transforming growth factor alpha, hepatocyte growth factor, and acidic fibroblast growth factor in early proliferation. (1993) (130)
Wild-type p53 controls cell motility and invasion by dual regulation of MET expression (2011) (129)
Ovarian aryl hydrocarbon hydroxylase activity and primordial oocyte toxicity of polycyclic aromatic hydrocarbons in mice. (1979) (127)
Association of TP53 mutations with stem cell-like gene expression and survival of patients with hepatocellular carcinoma. (2011) (125)
Progenitor‐derived hepatocellular carcinoma model in the rat (2010) (125)
Inhibition of neoplastic development in the liver by hepatocyte growth factor in a transgenic mouse model. (1996) (125)
Regulation of 2‐acetylaminofluorene‐and 3‐methylcholanthrene‐mediated induction of multidrug resistance and cytochrome P450IA gene family expression in primary hepatocyte cultures and rat liver (1991) (124)
Progenitor cells in liver regeneration: molecular responses controlling their activation and expansion (2005) (123)
Evolution of neoplastic development in the liver of transgenic mice co-expressing c-myc and transforming growth factor-alpha. (1996) (122)
Role of the IκB Kinase Complex in Oncogenic Ras- and Raf-Mediated Transformation of Rat Liver Epithelial Cells (2000) (122)
Intact signaling by transforming growth factor β is not required for termination of liver regeneration in mice (2004) (120)
Comparative and integrative functional genomics of HCC (2006) (120)
Transgenic mouse model for synergistic effects of nuclear oncogenes and growth factors in tumorigenesis: interaction of c-myc and transforming growth factor alpha in hepatic oncogenesis. (1993) (120)
Wholesale hepatocytic differentiation in the rat from ductular oval cells, the progeny of biliary stem cells. (1997) (119)
The role of cytochrome P-450 in N-hydroxylation of 2-acetylaminofluorene. (1973) (119)
2‐acetylaminofluorene dose‐dependent differentiation of rat oval cells into hepatocytes: Confocal and electron microscopic studies (2004) (119)
NANOG modulates stemness in human colorectal cancer (2013) (118)
DLC‐1, a Rho GTPase‐activating protein with tumor suppressor function, is essential for embryonic development (2005) (114)
Functional and genomic implications of global gene expression profiles in cell lines from human hepatocellular cancer (2002) (114)
Expression of transforming growth factor‐alpha in regenerating liver and during hepatic differentiation (1992) (112)
Neuropilin-1 stimulates tumor growth by increasing fibronectin fibril assembly in the tumor microenvironment. (2012) (111)
Novel recurrent genetic imbalances in human hepatocellular carcinoma cell lines identified by comparative genomic hybridization (1999) (111)
E2F1 inhibits c-Myc-driven apoptosis via PIK3CA/Akt/mTOR and COX-2 in a mouse model of human liver cancer. (2008) (110)
In situ hybridization studies on expression of albumin and alpha-fetoprotein during the early stage of neoplastic transformation in rat liver. (1987) (109)
Hepatic Stem Cell Compartment: Activation and Lineage Commitment (1993) (106)
Loss of hepatocyte growth factor/c-Met signaling pathway accelerates early stages of N-nitrosodiethylamine induced hepatocarcinogenesis. (2007) (105)
Met and the epidermal growth factor receptor act cooperatively to regulate final nephron number and maintain collecting duct morphology (2009) (105)
Induction of multidrug resistance gene expression during cholestasis in rats and nonhuman primates (1993) (105)
Identification of potential driver genes in human liver carcinoma by genomewide screening. (2009) (104)
An Integrated Genomic and Epigenomic Approach Predicts Therapeutic Response to Zebularine in Human Liver Cancer (2010) (101)
Sixty‐five gene‐based risk score classifier predicts overall survival in hepatocellular carcinoma (2012) (101)
Dexamethasone inhibits the proliferation of hepatocytes and oval cells but not bile duct cells in rat liver (1998) (100)
Activation of beta-catenin during hepatocarcinogenesis in transgenic mouse models: relationship to phenotype and tumor grade. (2001) (99)
Epigenetic regulation of cancer stem cells in liver cancer: current concepts and clinical implications. (2010) (98)
Activation of the canonical Wnt/beta-catenin pathway confers growth advantages in c-Myc/E2F1 transgenic mouse model of liver cancer. (2005) (97)
Cellular and molecular changes in the early stages of chemical hepatocarcinogenesis in the rat. (1990) (96)
Constitutive expression of mature transforming growth factor beta1 in the liver accelerates hepatocarcinogenesis in transgenic mice. (1997) (96)
Specific fate decisions in adult hepatic progenitor cells driven by MET and EGFR signaling. (2013) (95)
Modulation of connexins during differentiation of oval cells into hepatocytes. (1994) (93)
Changes in liver blood flow during enzyme induction. (1971) (93)
Mutagenic activation of N-hydroxy-2-acetylaminofluorene in the Salmonella test system: the role of deacetylation by liver and kidney fractions from mouse and rat. (1978) (93)
mTOR Inhibitors Synergize on Regression, Reversal of Gene Expression, and Autophagy in Hepatocellular Carcinoma (2012) (92)
Disruption of beta-catenin pathway or genomic instability define two distinct categories of liver cancer in transgenic mice. (2004) (91)
Label-retaining liver cancer cells are relatively resistant to sorafenib (2013) (91)
Reaction of N-hydroxylamine and N-acetoxy derivatives of 2-amino-3-methylimidazolo[4,5-f]quinoline with DNA. Synthesis and identification of N-(deoxyguanosin-8-yl)-IQ. (1988) (91)
Expression of acidic fibroblast growth factor in regenerating liver and during hepatic differentiation. (1992) (90)
Role of HSP90, CDC37, and CRM1 as modulators of P16INK4A activity in rat liver carcinogenesis and human liver cancer (2005) (90)
Vitamin E down-modulates iNOS and NADPH oxidase in c-Myc/TGF-alpha transgenic mouse model of liver cancer. (2004) (89)
Genetic profiling of intrahepatic cholangiocarcinoma (2012) (89)
Mechanism of in vitro mutagenic activation and covalent binding of N-hydroxy-2-acetylaminofluorene in isolated liver cell nuclei from rat and mouse. (1978) (89)
Genomic Predictors for Recurrence Patterns of Hepatocellular Carcinoma: Model Derivation and Validation (2014) (87)
Downregulation of KLF6 is an early event in hepatocarcinogenesis, and stimulates proliferation while reducing differentiation. (2007) (86)
In vivo infusion of growth factors enhances the mitogenic response of rat hepatic ductal (oval) cells after administration of 2‐acetylaminofluorene (1996) (86)
Genome-Wide CRISPR Screen Identifies Regulators of Mitogen-Activated Protein Kinase as Suppressors of Liver Tumors in Mice. (2017) (85)
Human hepatic cancer stem cells are characterized by common stemness traits and diverse oncogenic pathways (2011) (83)
SnapShot: Hepatocellular carcinoma. (2014) (82)
8 – Liver stem cells* (1997) (82)
Species differences in the substrate specificity of hepatic cytochrome P-448 from polycyclic hydrocarbon-treated animals. (1979) (82)
Modulation of keratin 14 and α‐fetoprotein expression during hepatic oval cell proliferation and liver regeneration (1994) (82)
Role of growth hormone (GH) in liver regeneration. (2004) (82)
Molecular Mechanisms of Hepatocarcinogenesis in Transgenic Mouse Models of Liver Cancer (2005) (81)
Hepatocyte-specific c-Met Deletion Disrupts Redox Homeostasis and Sensitizes to Fas-mediated Apoptosis* (2008) (80)
Dysregulation of apoptosis in hepatocellular carcinoma. (1998) (79)
RB loss abrogates cell cycle control and genome integrity to promote liver tumorigenesis. (2007) (79)
Evidence for a common cell of origin for primitive epithelial cells isolated from rat liver and pancreas (1991) (78)
Proliferation, apoptosis, and induction of hepatic transcription factors are characteristics of the early response of biliary epithelial (oval) cells to chemical carcinogens (1996) (78)
Global gene expression profiles of human head and neck squamous carcinoma cell lines (2004) (78)
Expression of transforming growth factor alpha/epidermal growth factor receptor, hepatocyte growth factor/c-met and acidic fibroblast growth factor/fibroblast growth factor receptors during hepatocarcinogenesis. (1993) (78)
Precursor-product relationship between oval cells and hepatocytes: comparison between tritiated thymidine and bromodeoxyuridine as tracers. (1996) (77)
Keratin 14 protein in cultured nonparenchymal rat hepatic epithelial cells: Characterization of keratin 14 and keratin 19 as antigens for the commonly used mouse monoclonal antibody OV‐6 (1993) (75)
Low frequency of p53 gene mutation in tumors induced by aflatoxin B1 in nonhuman primates. (1992) (75)
Sequential transcriptome analysis of human liver cancer indicates late stage acquisition of malignant traits. (2014) (75)
Coexpression of stem cell factor and c-kit in embryonic and adult liver. (1996) (75)
Coactivation of AKT and β-catenin in mice rapidly induces formation of lipogenic liver tumors. (2011) (74)
Loss of c-Met Disrupts Gene Expression Program Required for G2/M Progression during Liver Regeneration in Mice (2010) (74)
Relationship between "aromatic hydrocarbon responsiveness" and the survival times in mice treated with various drugs and environmental compounds. (1975) (74)
Epigenetic reprogramming modulates malignant properties of human liver cancer (2014) (74)
Expression of leukemia inhibitory factor and its receptor during liver regeneration in the adult rat. (1996) (74)
Measurement of cell proliferation in microculture using Hoechst 33342 for the rapid semiautomated microfluorimetric determination of chromatin DNA. (1985) (72)
Expression of α‐fetoprotein and stem cell factor/c‐kit system in bile duct ligated young rats (1997) (72)
Dose‐dependent enzyme induction (1973) (72)
Histopathology and gene expression changes in rat liver during feeding of fumonisin B1, a carcinogenic mycotoxin produced by Fusarium moniliforme. (1999) (71)
Reconstitution of liver mass via cellular hypertrophy in the rat (2001) (71)
Expression of multidrug resistance genes in rat liver during regeneration and after carbon tetrachloride intoxication (1993) (71)
Loss of c-Met accelerates development of liver fibrosis in response to CCl(4) exposure through deregulation of multiple molecular pathways. (2012) (70)
Exploring genomic profiles of hepatocellular carcinoma (2011) (69)
Reduced hepatic tumor incidence in cyclin G1‐deficient mice (2003) (69)
Individual differences in cancer susceptibility. (1980) (69)
Cellular distribution of c-myc transcripts during chemical hepatocarcinogenesis in rats. (1988) (69)
MYC activates stem-like cell potential in hepatocarcinoma by a p53-dependent mechanism. (2014) (69)
Dramatic reduction of liver cancer incidence in young adults: 28 year follow-up of etiological interventions in an endemic area of China. (2013) (68)
Molecular prognostication of liver cancer: end of the beginning. (2006) (68)
Metabolic activation: biochemical basis for many drug-induced liver injuries. (1976) (68)
Induction of p53 and Bax during TGF-beta 1 initiated apoptosis in rat liver epithelial cells. (1998) (68)
Antitumor effects in hepatocarcinoma of isoform-selective inhibition of HDAC2. (2014) (67)
The Transcription Factor GLI1 Mediates TGFβ1 Driven EMT in Hepatocellular Carcinoma via a SNAI1-Dependent Mechanism (2012) (66)
Definition of ubiquitination modulator COP1 as a novel therapeutic target in human hepatocellular carcinoma. (2010) (66)
Inhibition of CK2 Activity by TGF‐β1 Promotes IκB‐α Protein Stabilization and Apoptosis of Immortalized Hepatocytes (2003) (66)
Overview of recent experimental studies on liver stem cells. (2003) (66)
Sulfatase 1 and sulfatase 2 in hepatocellular carcinoma: Associated signaling pathways, tumor phenotypes, and survival (2011) (65)
Catalysis of divergent pathways of 2-acetylaminofluorene metabolism by multiple forms of cytochrome P-450. (1980) (65)
Roles of Akt/PKB and IKK complex in constitutive induction of NF‐κB in hepatocellular carcinomas of transforming growth factor α/c‐myc transgenic mice (2001) (65)
Coexpression of flt-3 ligand/flt-3 and SCF/c-kit signal transduction system in bile-duct-ligated SI and W mice. (1997) (65)
LACK OF MUTAGENIC ACTIVITY IN URINE FROM HOSPITAL PHARMACISTS ADMIXING ANTITUMOUR DRUGS (1981) (64)
Molecular profiling of hepatocellular carcinomas developing spontaneously in acyl-CoA oxidase deficient mice: comparison with liver tumors induced in wild-type mice by a peroxisome proliferator and a genotoxic carcinogen. (2003) (64)
Metabolism and activation of 2-acetylaminofluorene in isolated rat hepatocytes. (1979) (64)
Expression of cellular myc and mos genes in undifferentiated B cell lymphomas of Burkitt and non-Burkitt types. (1983) (63)
Heterozygous mice for the transforming growth factor-beta type II receptor gene have increased susceptibility to hepatocellular carcinogenesis. (2001) (63)
Modulation of the gene network connected to interferon-γ in liver regeneration from oval cells (1999) (63)
Tumor‐Initiating Label‐Retaining Cancer Cells in Human Gastrointestinal Cancers Undergo Asymmetric Cell Division (2012) (62)
Gonadal aryl hydrocarbon hydroxylase in rats and mice. (1978) (62)
Acceleration of c-myc-induced hepatocarcinogenesis by Co-expression of transforming growth factor (TGF)-alpha in transgenic mice is associated with TGF-beta1 signaling disruption. (1999) (62)
Development of resistance to the growth inhibitory effects of transforming growth factor beta 1 during the spontaneous transformation of rat liver epithelial cells. (1991) (62)
A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability (1998) (61)
Metabolic activation of 2,4-diamino-anisole, a hair-dye component--I. Role of cytochrome p-450 metabolism in mutagenicity in vitro. (1977) (61)
Mechanism of N-hydroxyacetylarylamine mutagenicity in the Salmonella test system: metabolic activation of N-hydroxyphenacetin by liver and kidney fractions from rat, mouse, hamster, and man. (1980) (61)
β-Cell-Specific Ablation of the Hepatocyte Growth Factor Receptor Results in Reduced Islet Size, Impaired Insulin Secretion, and Glucose Intolerance (2005) (60)
Effect of cyclophosphamide on oocyte and follicle number in Sprague-Dawley rats, C57BL/6N and DBA/2N mice. (1984) (60)
Mutagenicity and in vitro covalent DNA binding of 2-hydroxyamino-3-methylimidazolo[4,5-f]quinoline. (1988) (60)
Role of TGF‐Beta in Normal Differentiation and Oncogenesis in Rat Liver (1989) (60)
Activation of NF‐κB and STAT3 in rat oval cells during 2‐acetylaminofluorene/partial hepatectomy‐induced liver regeneration (2004) (59)
Mutagenic activation of IQ, PhIP and MeIQx by hepatic microsomes from rat, monkey and man: low mutagenic activation of MeIQx in cynomolgus monkeys in vitro reflects low DNA adduct levels in vivo. (1993) (59)
Genetic differences in the aromatic hydrocarbon-inducible n-hydroxylation of 2-acetylaminofluorene and acetaminophen-produced hepatotoxicity in mice. (1975) (59)
E2F1 blocks and c-Myc accelerates hepatic ploidy in transgenic mouse models. (2003) (59)
Drug interactions with warfarin: studies with dichloralphenazone, chloral hydrate and phenazone (antipyrine). (1971) (57)
Hint2, a mitochondrial apoptotic sensitizer down-regulated in hepatocellular carcinoma. (2006) (57)
The possible involvement of cytochrome b5 in the oxidation of lauric acid by microsomes from kidney cortex and liver of rats. (1974) (57)
Contribution of Hepatic Lineage Stage‐Specific Donor Memory to the Differential Potential of Induced Mouse Pluripotent Stem Cells (2012) (56)
Sequential analysis of chemically induced hepatoma development in rats by two dimensional electrophoresis. (1986) (56)
Genetic profiling of human hepatocellular carcinoma. (2005) (56)
Ethanol inhibits liver regeneration in rats without reducing transcripts of key protooncogenes. (1990) (56)
Oncogene‐specific gene expression signatures at preneoplastic stage in mice define distinct mechanisms of hepatocarcinogenesis (2006) (56)
Translating bioinformatics in oncology: guilt-by-profiling analysis and identification of KIF18B and CDCA3 as novel driver genes in carcinogenesis (2015) (56)
Metabolism of food-derived heterocyclic amines in nonhuman primates. (1997) (56)
Effect of ethanol on polyamine synthesis during liver regeneration in rats. (1990) (55)
Ploidy and karyotypic alterations associated with early events in the development of hepatocarcinogenesis in transgenic mice harboring c-myc and transforming growth factor alpha transgenes. (1996) (54)
Stem cells in hepatocarcinogenesis: evidence from genomic data. (2010) (54)
Interindividual differences in rates of drug oxidation in man. (1973) (53)
Use of the 32P-postlabeling method to detect DNA adducts of 2-amino-3-methylimidazolo[4,5-f]quinoline (IQ) in monkeys fed IQ: identification of the N-(deoxyguanosin-8-yl)-IQ adduct. (1988) (52)
Comparative functional genomics for identifying models of human cancer. (2005) (52)
Expression of hepatitis B surface and core antigens and transforming growth factor‐a in “oval cells” of the liver in patients with hepatocellular carcinoma (1994) (52)
Computer analysis of two‐dimensional gels: Automatic matching (1984) (51)
Neoplastic transformation and lineage switching of rat liver epithelial cells by retrovirus‐associated oncogenes (1988) (50)
Identification of microRNAs specific for epithelial cell adhesion molecule–positive tumor cells in hepatocellular carcinoma (2015) (50)
Glutathione synthesis and degradation in fetal and adult rat liver and Novikoff hepatoma. (1978) (50)
The methyltransferases enhancer of zeste homolog (EZH) 1 and EZH2 control hepatocyte homeostasis and regeneration (2015) (48)
Genetic differences in 2-acetylaminofluorene mutagenicity in vitro associated with mouse hepatic aryl hydrocarbon hydroxylase activity induced by polycyclic aromatic compounds. (1976) (48)
Integrative Genomics Identifies YY1AP1 as an Oncogenic Driver in EpCAM+ AFP+ Hepatocellular Carcinoma (2014) (47)
HGF-mediated apoptosis via p53/bax-independent pathway activating JNK1. (1999) (46)
Transcriptional and post-transcriptional regulation of the asialoglycoprotein receptor in normal and neoplastic rat liver. (1986) (46)
Transgenic mouse models in carcinogenesis research and testing. (2000) (46)
Role of sulfotransferase from rat liver in the mutagenicity of N-hydroxy-2-acetylaminofluorene in Salmonella typhimurium (1977) (46)
Biochemical changes after hepatic injury from toxic doses of acetaminophen or furosemide. (1976) (46)
Transgenic mouse models in carcinogenesis: interaction of c-myc with transforming growth factor alpha and hepatocyte growth factor in hepatocarcinogenesis. (2003) (46)
Transcriptional Induction of Periostin by a Sulfatase 2-TGFβ1-SMAD Signaling Axis Mediates Tumor Angiogenesis in Hepatocellular Carcinoma. (2017) (46)
Disregulation of E-cadherin in transgenic mouse models of liver cancer (2004) (46)
An improved high-pressure liquid chromatographic assay for 2-acetylaminofluorene and eight of its metabolites. (1981) (45)
In vitro metabolism and activation of carcinogenic aromatic amines by subcellular fractions of human liver. (1979) (45)
Recognition properties of peptides hydropathically complementary to residues 356-375 of the c-raf protein. (1989) (45)
In vitro metabolism and mutagenic activation of 2-acetylaminofluorene by subcellular liver fractions from Cotton rats. (1978) (45)
Lack of mitochondrial topoisomerase I (TOP1mt) impairs liver regeneration (2015) (45)
Genomic modeling of tumor onset and progression in a mouse model of aggressive human liver cancer. (2011) (45)
Identification of a mitochondrial defect gene signature reveals NUPR1 as a key regulator of liver cancer progression (2015) (44)
Correlation of immunohistochemical staining and mutations of p53 in human hepatocellular carcinoma. (2000) (44)
Activation of β-catenin provides proliferative and invasive advantages in c- myc/TGF-α hepatocarcinogenesis promoted by phenobarbital (2004) (44)
Tumorigenicity and transcriptional modulation of c-myc and N-ras oncogenes in a human hepatoma cell line. (1985) (44)
Homologous and heterologous Gap‐junctional intercellular communication in v‐raf‐, v‐myc‐, and v‐raf/v‐myc‐transduced rat liver epithelial cell lines (1992) (43)
CLPTM1L promotes growth and enhances aneuploidy in pancreatic cancer cells. (2014) (43)
Isolation of live label-retaining cells and cells undergoing asymmetric cell division via nonrandom chromosomal cosegregation from human cancers. (2011) (42)
Cyclin G Recruits PP 2 A to Dephosphorylate Mdm 2 (2002) (42)
Metabolic processing and carcinogenicity of heterocyclic amines in nonhuman primates. (1990) (42)
Polymorphic metabolism of the carcinogen 2-acetylaminofluorene in human liver microsomes. (1985) (42)
Coexpression of C‐myc and transforming growth factor alfa in the liver promotes early replicative senescence and diminishes regenerative capacity after partial hepatectomy in transgenic mice (1997) (41)
Zonal distribution of transcripts of four hepatic transcription factors in the mature rat liver (1997) (41)
Expression of fibroblast growth factor receptors flg and bek during hepatic ontogenesis and regeneration in the rat. (1995) (41)
Genes Associated with Recurrence of Hepatocellular Carcinoma: Integrated Analysis by Gene Expression and Methylation Profiling (2011) (41)
Altered responsiveness of rat liver epithelial cells to transforming growth factor beta 1 following their transformation with v-raf. (1990) (40)
Reduced growth capacity of hepatocytes from c-myc and c-myc/TGF-alpha transgenic mice in primary culture. (1996) (40)
Differential induction of murine Ah locus-associated monooxygenase activities in rabbit liver and kidney. (1975) (40)
Analysis of c-myc expression in a human hepatoma cell line. (1987) (40)
Metabolic processing of 2-acetylaminofluorene by microsomes and six highly purified cytochrome P-450 forms from rabbit liver. (1984) (40)
Biochemical changes after hepatic injury by allyl alcohol and N-hydroxy-2-acetylaminofluorene. (1976) (39)
Amine oxidase in mice-sex differences and developmental aspects. (1978) (39)
Ontogeny of ovarian glutathione and sensitivity to primordial oocyte destruction by cyclophosphamide. (1983) (39)
DNMT1 is a required genomic regulator for murine liver histogenesis and regeneration (2016) (39)
Dysregulation of DNA Repair Pathways in a Transforming Growth Factor α/c-myc Transgenic Mouse Model of Accelerated Hepatocarcinogenesis (2003) (39)
Mechanism of N-hydroxy-2-acetylaminofluorene mutagenicity in the Salmonella test system. Role of N-O acyltransferase and sulfotransferase from rat liver. (1981) (39)
Growth inhibition and induction of apoptosis by HGF in transformed rat liver epithelial cells. (1997) (39)
Characterization of a transforming N-ras gene in the human hepatoma cell line Hep G2: additional evidence for the importance of c-myc and ras cooperation in hepatocarcinogenesis. (1990) (39)
Stable expression of human cytochrome P450IIE1 in mammalian cells: metabolic activation of nitrosodimethylamine and formation of adducts with cellular DNA. (1992) (39)
Spontaneous differentiation of mouse embryonic stem cells in vitro: characterization by global gene expression profiles. (2005) (38)
Relationship between NADH and NADPH oxidation during drug metabolism. (1973) (38)
The antiandrogen cyproterone acetate induces synthesis of transforming growth factor β1 in the parenchymal cells of the liver accompanied by an enhanced sensitivity to undergo apoptosis and necrosis without inflammation (1996) (37)
Role of the IkappaB kinase complex in oncogenic Ras- and Raf-mediated transformation of rat liver epithelial cells. (2000) (37)
In vivo mutagenicity and DNA adduct levels of heterocyclic amines in Muta mice and c-myc/lacZ double transgenic mice. (1996) (37)
Glutathione in the developing mouse liver--I. Developmental curve and depletion after acetaminophen treatment. (1976) (37)
Expression of alpha-fetoprotein and stem cell factor/c-kit system in bile duct ligated young rats. (1997) (36)
Roles of Akt/PKB and IKK complex in constitutive induction of NF-kappaB in hepatocellular carcinomas of transforming growth factor alpha/c-myc transgenic mice. (2001) (36)
An integrated transcriptome and epigenome analysis identifies a novel candidate gene for pancreatic cancer (2013) (36)
Transcriptomic and histopathological analysis of cholangiolocellular differentiation trait in intrahepatic cholangiocarcinoma (2018) (36)
Inhibition of CK2 activity by TGF-beta1 promotes IkappaB-alpha protein stabilization and apoptosis of immortalized hepatocytes. (2003) (36)
Biphasic regulation of the NADPH oxidase by HGF/c-Met signaling pathway in primary mouse hepatocytes. (2013) (36)
Modulation of the plasminogen activator/plasmin system in rat liver regenerating by recruitment of oval cells. (1998) (36)
Hepatic stem cells. (1993) (36)
STAT-3 activity in chemically-induced hepatocellular carcinoma. (2003) (35)
Plasma concentration of phenylbutazone and its therapeutic effect-studies in patients with rheumatoid arthritis. (1976) (35)
Cytotoxic effects of N-hydroxyparacetamol in suspsensions of isolated rat hepatocytes. (2009) (35)
Thioacetamide-induced hepatic fibrosis in transforming growth factor beta-1 transgenic mice (2004) (35)
Induction of hepatic aneuploidy in vivo by tamoxifen, toremifene and idoxifene in female Sprague-Dawley rats. (1996) (35)
Oncogenic driver genes and the inflammatory microenvironment dictate liver tumor phenotype (2016) (35)
Transforming Growth Factor-β1 in Plasma and Liver of Children with Liver Disease (1998) (34)
Genetic signatures shared in embryonic liver development and liver cancer define prognostically relevant subgroups in HCC (2012) (34)
Deletion of the Met tyrosine kinase in liver progenitor oval cells increases sensitivity to apoptosis in vitro. (2008) (34)
Regulation of cyclin G1 during murine hepatic regeneration following dipin‐induced DNA damage (1998) (34)
Metabolic activation and genotoxicity of heterocyclic arylamines. (1992) (34)
Transforming growth factor-beta1 recruits histone deacetylase 1 to a p130 repressor complex in transgenic mice in vivo. (2000) (34)
Mutagenicity of N-hydroxy-2-acetylaminofluorene and N-hydroxy-phenacetin and their respective deacetylated metabolites in nitroreductase deficient Salmonella TA98FR and TA100FR. (1982) (33)
The effects of cyclophosphamide, azathioprine, and 6-mercaptopurine on oocyte and follicle number in C57BL/6N mice. (1981) (33)
Human homologue of maid: A dominant inhibitory helix‐loop‐helix protein associated with liver‐specific gene expression (2000) (33)
Beta-cell-specific ablation of the hepatocyte growth factor receptor results in reduced islet size, impaired insulin secretion, and glucose intolerance. (2005) (33)
Gene expression profiling demonstrates that TGF-β1 signals exclusively through receptor complexes involving Alk5 and identifies targets of TGF-β signaling (2005) (32)
Expression of transforming growth factor-beta 1 during chemical hepatocarcinogenesis in the rat. (1991) (32)
Induction of common patterns of polypeptide synthesis and phosphorylation by calcium and 12-O-tetradecanoylphorbol-13-acetate in mouse epidermal cell culture. (1987) (32)
Isolation of preneoplastic rat liver cells by centrifugal elutriation and binding to asialofetuin. (1984) (32)
The biological and clinical challenge of liver cancer heterogeneity. (2014) (31)
Liver under Constant Attack — From Fat to Viruses (2009) (31)
Growth modulatory effects of a liver-derived growth inhibitor, transforming growth factor β1, and recombinant tumor necrosis factor α, in normal and neoplastic cells (1989) (31)
De novo deposition of laminin‐positive basement membrane in vitro by normal hepatocytes and during hepatocarcinogenesis (1988) (31)
Triiodothyronine accelerates differentiation of rat liver progenitor cells into hepatocytes (2008) (30)
Phenotypic modulation of keratins, vimentin, and α‐fetoprotein in cultured rat liver epithelial cells after chemical, oncogene, and spontaneous transformation (1994) (30)
Expression of growth-related genes during tumor progression in v-raf-transformed rat liver epithelial cells. (1990) (30)
Thyroid regeneration: characterization of clear cells after partial thyroidectomy. (2012) (30)
Separation and quantitative determination of 2-acetyl-aminofluorene and its hydroxylated metabolites by high pressure liquid chromatography. (1976) (30)
Regulation of α-Fetoprotein by Nuclear Factor-κB Protects Hepatocytes from Tumor Necrosis Factor-α Cytotoxicity during Fetal Liver Development and Hepatic Oncogenesis (2004) (30)
Expression of transcription factors and stem cell factor precedes hepatocyte differentiation in rat pancreas. (1996) (29)
Synthesis, purification and mutagenicity of 2-hydroxyamino-3-methylimidazolo[4,5-f]quinoline. (1987) (29)
Transforming Growth Factor-α Inhibits the Intrinsic Pathway of c-Myc-Induced Apoptosis through Activation of Nuclear Factor-κB in Murine Hepatocellular Carcinomas (2005) (29)
Individual differences in the plasma half-lives of lipid soluble drugs in man. (2009) (29)
Transcriptional and post-transcriptional regulation of c-myc, c-myb, and p53 during proliferation and differentiation of murine erythroleukemia cells treated with DFMO and DMSO. (1988) (28)
Genetic differences in mouse ovarian metabolism of benzo [a]pyrene and oocyte toxicity. (1977) (28)
Activation of beta-catenin provides proliferative and invasive advantages in c-myc/TGF-alpha hepatocarcinogenesis promoted by phenobarbital. (2004) (28)
Similar patterns of DNA adduct formation of 2-amino-3-methylimidazo [4,5-f]quinoline in the Fischer 344 rat, CDF1 mouse, cynomolgus monkey and Salmonella typhimurium. (1991) (27)
Enhanced Tumor Formation in Cyclin D1 × Transforming Growth Factor β1 Double Transgenic Mice with Characterization by Magnetic Resonance Imaging (2004) (27)
Short-term carcinogenicity testing of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in E(mu)-pim-1 transgenic mice. (1996) (27)
Expression of hepatitis B surface and core antigens and transforming growth factor-alpha in "oval cells" of the liver in patients with hepatocellular carcinoma. (1994) (26)
Characterization of a hepatic proliferation inhibitor (HPI): Effect of HPI on the growth of normal liver cells—comparison with transforming growth factor beta (1987) (26)
Modulation of asialoglycoprotein receptor levels in rat liver by phenobarbital treatment. (1985) (26)
ΔNp73β is oncogenic in hepatocellular carcinoma by blocking apoptosis signaling via death receptors and mitochondria (2010) (25)
In vitro differentiation of rat liver derived stem cells results in sensitization to TNFα‐mediated apoptosis (2004) (25)
Regulation of heme metabolism and cytochrome P-450 levels in primary culture of rat hepatocytes in a defined medium. (1984) (25)
Secreted and cellular polypeptide patterns of MCF-7 human breast cancer cells following either estrogen stimulation or v-H-ras transfection. (1989) (25)
Studies of gene transcription and translation in regenerating rat liver (1986) (25)
Phenobarbital promotes liver growth in c-myc/TGF-alpha transgenic mice by inducing hypertrophy and inhibiting apoptosis. (1999) (25)
Altered polypeptide expression associated with neoplastic transformation of Syrian hamster cells by bisulfite. (1986) (25)
Gene structure, tissue expression, and linkage mapping of the mouse DLC-1 gene (Arhgap7). (2002) (25)
Proteoglycan gene expression in rat liver after partial hepatectomy. (1996) (24)
Kinetics of N- and C-hydroxylations of 2-acetylaminofluorene in male Sprague-Dawley rat liver microsomes: implications for carcinogenesis. (1983) (24)
Human homologue of maid is a useful marker protein in hepatocarcinogenesis. (2005) (24)
Cellular pattern of multidrug‐resistance gene expression during chemical hepatocarcinogenesis in the rat (1992) (24)
Liver Label Retaining Cancer Cells Are Relatively Resistant to the Reported Anti-Cancer Stem Cell Drug Metformin (2016) (24)
Hepatic regeneration in vitamin A-deficient rats: changes in the expression of transforming growth factor alpha/epidermal growth factor receptor and retinoic acid receptors alpha and beta. (1994) (23)
Gene expression profiling demonstrates that TGF-beta1 signals exclusively through receptor complexes involving Alk5 and identifies targets of TGF-beta signaling. (2005) (23)
Oligonucleotide microarray analysis of aminoallyl-labeled cDNA targets from linear RNA amplification. (2004) (23)
Heat Stress-Induced PI3K/mTORC2-Dependent AKT Signaling Is a Central Mediator of Hepatocellular Carcinoma Survival to Thermal Ablation Induced Heat Stress (2016) (23)
SMAD5 gene expression, rearrangements, copy number, and amplification at fragile site FRA5C in human hepatocellular carcinoma. (2003) (23)
Chemical hepatocarcinogenesis in transgenic mice overexpressing mature TGF beta-1 in liver. (1999) (23)
Effect of ascorbic acid on in vitro mutagenicity and in vivo covalent binding of N-hydroxy-2-acetylaminofluorene in the rat. (1980) (22)
Modulation of the gene network connected to interferon-gamma in liver regeneration from oval cells. (1999) (22)
Transforming growth factor-alpha inhibits the intrinsic pathway of c-Myc-induced apoptosis through activation of nuclear factor-kappaB in murine hepatocellular carcinomas. (2005) (22)
A Gene Expression Signature Associated with Overall Survival in Patients with Hepatocellular Carcinoma Suggests a New Treatment Strategy (2016) (22)
Relationship between oxidative metabolism of 2-acetylaminofluorene, debrisoquine, bufuralol, and aldrin in human liver microsomes. (1984) (22)
Bacterial mutagenesis and host cell DNA damage by chemical carcinogens in the Salmonella/hepatocyte system. (1980) (22)
Activation of mutagenic and carcinogenic heterocyclic amines by S-9 from the liver of a rhesus monkey. (1987) (21)
Cardiotoxicity of heterocyclic amine food mutagens in cultured myocytes and in rats. (1994) (21)
Long-term exposure to elevated levels of circulating TIMP-1 but not mammary TIMP-1 suppresses growth of mammary carcinomas in transgenic mice. (2004) (21)
Studies on the mechanism of acetamide hepatocarcinogenicity. (1987) (21)
Wnt and the Cancer Niche: Paracrine Interactions with Gastrointestinal Cancer Cells Undergoing Asymmetric Cell Division (2013) (21)
Genotoxicity of heterocyclic amines in the Salmonella/hepatocyte system. (1985) (20)
Effects of interleukin-6 on the growth of normal and transformed rat liver cells in culture. (1989) (20)
Demethylation of 3-O-methyldopa in the rat (1971) (20)
Comparative testing of various pancreatic cancer stem cells results in a novel class of pancreatic-cancer-initiating cells. (2012) (19)
DNA variants of DLC-1, a candidate tumor suppressor gene in human hepatocellular carcinoma. (2003) (19)
Mutagenicity and DNA damage induced by arylamines in the Salmonella/hepatocyte system. (1983) (19)
DNA adducts of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in colon, bladder, and kidney of congenic mice differing in Ah responsiveness and N-acetyltransferase genotype. (1995) (19)
Molecular constituents of the extracellular matrix in rat liver mounting a hepatic progenitor cell response for tissue repair (2013) (19)
Induction of peroxisome proliferation in hepatocytes transplanted into the anterior chamber of the eye. A model system for the evaluation of xenobiotic-induced effects. (1986) (19)
Genetic aspects of toxicity during development. (1976) (19)
A perspective on molecular therapy in cholangiocarcinoma: present status and future directions. (2014) (18)
Regulation of alpha-fetoprotein by nuclear factor-kappaB protects hepatocytes from tumor necrosis factor-alpha cytotoxicity during fetal liver development and hepatic oncogenesis. (2004) (18)
Cytochrome P4501A2 constitutively expressed from transduced DNA mediates metabolic activation and DNA‐adduct formation of aromatic amine carcinogens in NIH 3T3 cells (1991) (18)
Association between DNA strand breaks and specific DNA adducts in murine hepatocytes following in vivo and in vitro exposure to N-hydroxy-2-acetylaminofluorene and N-acetoxy-2-acetylaminofluorene. (1985) (18)
Ligand-induced modulation of the hepatic receptor for asialoglycoproteins in the human hepatoblastoma cell line, Hep G2. (1987) (18)
Hepatic regeneration. The role of regeneration in pathogenesis of chronic liver diseases. (1996) (18)
Kinetic evidence for the involvement of multiple forms of human liver cytochrome P-450 in the metabolism of acetylaminofluorene. (1983) (18)
Loss of c-Met signaling sensitizes hepatocytes to lipotoxicity and induces cholestatic liver damage by aggravating oxidative stress. (2016) (18)
Promotion of Hepatocarcinogenesis by Phenobarbital in c‐myc/TGF‐α Transgenic Mice (2000) (17)
ENDOCRINE EXPRESSION OF THE ACTIVE FORM OF TGF-β1 IN THE TGF-β1 NULL MICE FAILS TO AMELIORATE LETHAL PHENOTYPE (2002) (17)
Establishment of Human Ultra-Low Passage Colorectal Cancer Cell Lines Using Spheroids from Fresh Surgical Specimens Suitable for In Vitro and In Vivo Studies (2012) (17)
c‐Met Signaling Is Essential for Mouse Adult Liver Progenitor Cells Expansion After Transforming Growth Factor‐β‐Induced Epithelial–Mesenchymal Transition and Regulates Cell Phenotypic Switch (2019) (17)
Effect of vitamin A deficiency on the integrity of hepatocytes after partial hepatectomy. (1995) (17)
Induction of monooxygenases in rhesus monkeys by 3-methylcholanthrene: metabolism and mutagenic activation of N-2-acetylaminofluorene and benzo(a)pyrene. (1978) (16)
Loss of PDPK1 abrogates resistance to gemcitabine in label-retaining pancreatic cancer cells (2018) (16)
Influence of conjugation reactions on the mutagenicity of aromatic amines. (1983) (16)
In vivo expression and genomic organization of the mouse cyclin I gene (Ccni). (2000) (16)
Studies on the carcinogenic and myocardial effects of 2-amino-3-methylimidazo [4,5-f] quinoline (IQ) in nonhuman primates. (1995) (16)
Genome-Wide RNAi Screen Identifies PMPCB as a Therapeutic Vulnerability in EpCAM+ Hepatocellular Carcinoma. (2019) (16)
The high transforming potency of erbB-2 and ret is associated with phosphorylation of paxillin and a 23 kDa protein. (1994) (16)
Short-term carcinogenicity testing of a potent murine intestinal mutagen, 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP), in Apc1638N transgenic mice. (1997) (16)
Implication of hydrogen peroxide generation and apoptosis in the neoplastic transformation of mouse fibroblasts overexpressing peroxisomal fatty acyl-CoA oxidase. (1998) (16)
Plasma glutamate carboxypeptidase is a negative regulator in liver cancer metastasis (2016) (15)
Mutagenicity of D- and L-azaserine, 6-diazo-5-oxo-L-norleucine and N-(N-methyl-N-nitroso-carbamyl)-L-ornithine in the Salmonella test system. (1980) (15)
Molecular analyses of liver tumors in c-myc transgenic mice and c-myc and TGF-alpha double transgenic mice. (1996) (15)
Detection of a tyrosine-phosphorylated form of cyclin A during liver regeneration. (1997) (15)
Application of patient derived liver cancer cell lines for phenotypic characterization and therapeutic target identification (2018) (15)
Transcriptome analysis of liver cancer: ready for the clinic? (2009) (15)
Development of an in vitro model of tumor progression using v‐raf and v‐raf/v‐myc transformed rat liver epithelial cells: Correlation of tumorigenicity with the downregulation of specific proteins (1990) (14)
Inhibition of 2-acetylaminofluorene oxidations by monoclonal antibodies specific to 3-methylcholanthrene-induced rat liver cytochrome P450. (1983) (14)
Guanethidine N-oxide formation as a measure of cellular flavin-containing monooxygenase activity. (1983) (14)
Adverse genomic alterations and stemness features are induced by field cancerization in the microenvironment of hepatocellular carcinomas (2017) (14)
Genomic decoding of intrahepatic cholangiocarcinoma reveals therapeutic opportunities. (2013) (14)
p53 Gene Mutation in Hepatocellular Carcinoma Induced by 2‐Amino‐3‐methylimidazo[4,5‐f]quinoline in Nonhuman Primates (1994) (14)
Expression of stanniocalcin 1 in thyroid side population cells and thyroid cancer cells. (2015) (14)
Interaction of c-myc with transforming growth factor alpha and hepatocyte growth factor in hepatocarcinogenesis. (1997) (13)
Sall4 in "stemness"-driven hepatocarcinogenesis. (2013) (13)
Genomic decoding of hepatocellular carcinoma. (2006) (13)
Studies on hepatic gene expression in different liver regenerative models. (2000) (13)
Integrated Genomic Comparison of Mouse Models Reveals Their Clinical Resemblance to Human Liver Cancer (2018) (13)
Pathology of spontaneous and oncogene transformed rat liver epithelial cells and derived tumours in nude mice. (1992) (13)
Stem cells and hepatocarcinogenesis (1995) (13)
The Icelandic Cancer Project – a population-wide approach to studying cancer (2004) (13)
CellMinerHCC: a microarray‐based expression database for hepatocellular carcinoma cell lines (2014) (13)
Specific polypeptide differences in normal versus malignant human breast tissues by two-dimensional electrophoresis (1987) (13)
Hunting for tumor suppressor genes in liver cancer (2003) (13)
The genotoxicity of aromatic amines in primary hepatocytes isolated from C57BL/6 and DBA/2 mice. (1984) (13)
Analysis of human urine for mutagens associated with carcinoma of the bilharzial bladder by the Ames Salmonella plate assay: Interpretation employing quantitation of viable lawn bacteria (1983) (12)
Mutagenicity of urine from rats after administration of 2,4-diaminoanisole: the effect of microsomal enzyme inducers. (1980) (12)
Mutagenic activation of N-hydroxy-2-acetylaminofluorene by developing epithelial cells of rat small intestine and effects of antioxidants. (1979) (12)
Organizational Principles of the Liver (2020) (12)
Genomic copy number alterations with transcriptional deregulation at 6p identify an aggressive HCC phenotype. (2013) (12)
Immunopurification of the suppressor tRNA dependent rabbit beta-globin readthrough protein. (1988) (12)
Stemness and reprogramming in liver cancer (2016) (12)
The almighty MYC: orchestrating the micro-RNA universe to generate aggressive liver cancer. (2011) (12)
Ahr locus phenotype in congenic mice influences hepatic and pulmonary DNA adduct levels of 2-amino-3-methylimidazo[4,5-f]quinoline in the absence of cytochrome P450 induction. (1996) (11)
Promotion of hepatocarcinogenesis by phenobarbital in c-myc/TGF-alpha transgenic mice. (2000) (11)
Mutagenic activation of N-2-fluorenylacetamide and N-hydroxy-N-2-fluorenylacetamide in subcellular fractions from X/Gf mice. (1980) (11)
Molecular genetics of liver neoplasia (2011) (11)
Serial measurements of plasma half-lives and urinary excretion of antipyrine in low-birth-weight infants. (1975) (11)
Effect of inhibitors of ornithine decarboxylase on retrovirus induced transformation of murine erythroid precursors in vitro. (1986) (11)
Metabolism of 2-acetylaminofluorene in isolated rabbit pulmonary cells. Evidence for the heterogeneous distribution of monooxygenase activity in lung tissue. (1985) (11)
Histochemical changes in livers from portacaval-shunted rats. (1986) (10)
Possible relationship between tissue distribution of DNA adducts and genotoxicity of food-derived heterocyclic amines. (1995) (10)
Inter- and intraclonal variability of polypeptides synthesized in a rat hepatoma cell line. Quantitative two-dimensional gel analysis. (1988) (10)
Isolation and Characterization of a Rat Liver Epithelial Cell Line Resistant to the Antiproliferative Effects of Transforming Growth Factor β (Type 1) (1990) (10)
Linking MLL and the HGF-MET signaling pathway in liver cancer. (2013) (10)
Metabolic activation of 2-acetylaminofluorene. (1981) (10)
The role of cytochrome b5 in cytochrome P-450 enzymes. (1975) (10)
Lack of Carcinogenicity of 2‐Amino‐3,8‐dimethylimidazo[4,5‐f]quinoxaline (MeIQx) in Cynomolgus Monkeys (1999) (10)
Novel synthesis and spectral characterization of an N-acetoxyarylamine: N-acetoxy-2,4-dinitrophenylamine (1987) (10)
Endogenous DNA damage and breast cancer (1993) (9)
Rapid determination of DNA synthesis in adherent cells grown in microtiter plates. (1985) (9)
Mutagenicity of N-substituted aryl compounds in microbial systems. (1981) (9)
Transformation of Epstein-Barr virus immortalized human B-cells by chemical carcinogens. (1987) (9)
Developmental pattern of 3-methylcholanthrene-inducible mutagenic activation of N-2-fluorenylacetamide, 2-fluorenamine, and 2,4-diaminoanisole in the rabbit. (1980) (9)
Induction of epoxide hydrolase in cultured rat hepatocytes and hepatoma cell lines. (1985) (9)
Decoding developments in Iceland (1999) (9)
Growth modulatory effects of a liver-derived growth inhibitor, transforming growth factor beta 1, and recombinant tumor necrosis factor alpha, in normal and neoplastic cells. (1989) (9)
The Transcription Factor GTF2IRD1 Regulates the Topology and Function of Photoreceptors by Modulating Photoreceptor Gene Expression across the Retina (2014) (9)
Transgenic animals as models for hepatocarcinogenesis (1998) (9)
Stemness in Liver Cancer (2017) (8)
Recurrent and nonrandom DNA copy number and chromosome alterations in Myc transgenic mouse model for hepatocellular carcinogenesis: implications for human disease. (2009) (8)
Formation of DNA adducts from N-acetoxy-2-acetylaminofluorene and N-hydroxy-2-acetylaminofluorene in rat hemopoietic tissues in vivo. (1986) (8)
Target cell populations in virus-associated hepatocarcinogenesis. (1995) (8)
Disruption of the pRb / E 2 F Pathway and Inhibition of Apoptosis Are Major Oncogemc Events in Liver Constitutively Expressing c-myc and Transforming Growth Factor a (2006) (8)
Hepatic tumor induction in c-myc mono-transgenic and TGF-alpha/c-myc double-transgenic mice. (1997) (8)
Metabolism and mutagenic activation of 2-acetylaminofluorene by human liver and lung. (1981) (8)
The central role of the c-Met pathway in rebuilding the liver (2012) (8)
Endocrine expression of the active form of TGF-beta1 in the TGF-beta1 null mice fails to ameliorate lethal phenotype. (2002) (8)
Relationship between 7,12-dimethyl- and 7,8,12-trimethylbenz[a]anthracene DNA adduct formation in hematopoietic organs and leukemogenic effects. (1987) (7)
Structural requirements for mutagenic activity of 2-acylaminofluorenes in the Salmonella test system. (1976) (7)
Genetic differences in dimethylnitrosamine mutagenicity in vitro associated with mouse hepatic aryl hydrocarbon hydroxylase activity induced by 3-methylcholanthrene. (2009) (7)
Spontaneous metastasis of rat liver epithelial cells transformed with v-raf and v-raf/v-myc: association with different phenotypic properties. (1997) (7)
45 – Early Activation and Expansion of Hepatic Stem Cells (2004) (7)
Specific induction of hepatic cytochrome P4501a-2 in C57BL/6 and DBA/2 mice treated with 2-amino-3-methylimidazo[4,5-f]quinoline (IQ). (1993) (7)
Direct N‐terminal sequence analysis of rat liver plasma membrane glycoproteins separated by two‐dimensional polyacrylamide gel electrophoresis (1989) (7)
Genetic aspects of metabolic processing of chemical substances. (1979) (7)
Altered Expression of β-Globin, Transferrin Receptor, and Ornithine Decarboxylase in Friend Murine Erythroleukemia Cells Inhibited by α-Difluoromethylornithine (1987) (7)
Metabolic activation and genotoxicity of N-hydroxy-2-acetylaminofluorene and N-hydroxyphenacetin derivatives in Reuber (H4-II-E) hepatoma cells. (1984) (6)
Differentiation of Rat Liver Oval Cells into Hepatocytes In Vivo (1989) (6)
Lymphoma induction by heterocyclic amines in E mu-pim-1 transgenic mice. (1997) (6)
Next-generation genomic profiling of hepatocellular adenomas: a new era of individualized patient care. (2014) (6)
Covalent binding of foreign chemicals to tissue macromolecules. (1977) (6)
Sequence Directed Design of Recognition Peptides (1989) (6)
Inhibition of chemically induced erythrodifferentiation in Friends erythroleukemia cells by d,1-propranolol. (1980) (6)
Acquired Resistance to Antiangiogenic Therapies in Hepatocellular Carcinoma Is Mediated by Yes‐Associated Protein 1 Activation and Transient Expansion of Stem‐Like Cancer Cells (2021) (6)
Demethylation of 3-O-methyldopa. (1971) (6)
Progenitor cell tumors in human liver. (2008) (6)
Kinetics of sparteine metabolism in rat and rabbit liver microsomes (1985) (6)
Preferential activation and genotoxicity of food derived heterocyclic amine mutagens by recombinant cytochrome P4501A2. (1990) (6)
Epigenetic modifications precede molecular alterations and drive human hepatocarcinogenesis (2021) (5)
Kinetic studies of the N-demethylation of ethylmorphine by a cytochrome P-450-dependent enzyme system in human liver microsomes. (1971) (5)
Abstract 11: Asymmetric division via nonrandom chromosomal cosegregation potentially defines a novel class of universal cancer stem cells (2010) (5)
DNA damage induced by nitropyrenes in primary mouse hepatocytes and in rat H4-II-E hepatoma cells. (1985) (5)
Expression of microsomal and cytosolic epoxide hydrolases in cultured rat hepatocytes and hepatoma cell lines. (1983) (5)
Induction of aryl hydrocarbon (benzo[a]pyrene) hydroxylase and 2-acetylaminofluorene N-hydroxylase by polycyclic hydrocarbons in regenerating liver from inbred strains of mice. (1977) (5)
The role of biliary excretion in the hepatotoxicity of furosemide in the mouse. (1977) (5)
Developmental aspects of 2-acetamidofluorene metabolism and mutagenic activation in the chick. (1980) (5)
Modulation of N-hydroxyparacetamol cytotoxicity in suspensions of isolated rat hepatocytes. (2009) (5)
Screening methods for measuring liver microsomal enzyme induction by drugs. (1969) (4)
Interactions of TCDD with signal transduction and neoplastic development in c-myc transgenic and TGF-alpha transgenic mice. (1996) (4)
Genotoxicity of N-acetylarylamines in the Salmonella/hepatocyte system (1983) (4)
Abstract 1058: Mutations in isocitrate dehydrogenase 1 and 2 are associated with DNA hypermethylation in intrahepatic cholangiocarcinomas (2012) (4)
miR‐579‐3p Controls Hepatocellular Carcinoma Formation by Regulating the Phosphoinositide 3‐Kinase–Protein Kinase B Pathway in Chronically Inflamed Liver (2022) (4)
Aberrant expression and regulation of hepatic epidermal growth factor receptor in a c‐myc transgenic mouse model (1997) (4)
Redox Regulation by HGF/c-Met in Liver Disease (2017) (4)
[Characteristics of high frequency 249 codon mutation of p53 gene in hepatocellular carcinoma in prevalent area of China]. (1999) (4)
Evidence that reduction of hepatocyte growth factor (HGF) is not required for peroxisome proliferator-induced hepatocyte proliferation. (2001) (3)
Formation of reactive 1-nitropyrene metabolites by lung microsomes and isolated lung cells (1986) (3)
Heterogeneity of intercellular adhesion in rat liver cells in culture. (1987) (3)
Translating bioinformatics in oncology: Guilty by profiling meta-analysis and identification of KIF18B and CDCA3 as novel driver genes in liver carcinogenesis (2013) (3)
Cellular Biology of the Rat Hepatic Stem Cell Compartment (1994) (3)
Acquired genetic and functional alterations associated with transforming growth factor β type I resistance in Hep3B human hepatocellular carcinoma cell line (2009) (3)
THU-453-Dissecting the landscape of (epi-)genetic alterations during sequential evolution of liver cancer (2019) (3)
MS.liverK: an R package for transcriptome-based computation of molecular subtypes and functional signatures in liver cancer (2019) (3)
Molecular pathogenesis of human hepatocellular carcinoma: Mechanistic and prognostic significance of aberrant methylation (2006) (3)
Differential effects of dimethyl sulfoxide and sodium butyrate on α-fetoprotein, albumin, and transferrin production by rat hepatomas in culture (1981) (3)
Trait in Hepatocellular Carcinoma Identification of a Cholangiocarcinoma-Like Gene Expression (2010) (2)
The United States-Japan Cooperative Cancer Research Program seminar on "Cell cycle control and cancer". (1998) (2)
Studies on mutagenic and carcinogenic N-substituted aryl compounds: cosmetics and drugs. (1981) (2)
The influence of allopurinol and size of dose on the metabolism of phenylbutazone in patients with gout (1977) (2)
Overview of Cholangiocarcinoma and Evidence for a Primary Liver Carcinoma Spectrum (2010) (2)
Loss of HGF/c-met signaling pathway accelerates early stages of DEN-induced hepatocarcinogenesis (2006) (2)
Genetic databases. Decoding developments in Iceland. (1999) (2)
METABOLISM AND MUTAGENICITY OF 2-ACYLAMINOFLUORENES AND RELATED COMPOUNDS (1977) (2)
Selection of Transfected Cells (1997) (2)
Corrigendum: Induction of hepatic aneuploidy in vivo by tamoxifen, toremifene and idoxifene in female Sprague rats (Carcinogenesis (1996) 17 (1051-1056)) (1996) (2)
41 – COMPUTER ASSISTED DESIGN OF RECOGNITION PEPTIDES (1989) (1)
Loss of SIRT6 in hepatocellular carcinomas: associated molecular traits and clinical implications (2012) (1)
264 NF-KB and STAT-3 are required for hepatic stem cell activation (2003) (1)
Cellular and Molecular Changes in Early Stages of Hepatocarcinogenesis (1988) (1)
The eyes of transforming growth factor-sZ1 (TGF-sZ1) transgenic mice Morphology and the development of endotoxin-induced uveitis. (1996) (1)
113 KERATIN19: A KEY ROLE PLAYER IN THE INVASION OF HUMAN HEPATOCELLULAR CARCINOMAS WITH PROGENITOR CELL FEATURES (2012) (1)
The LEC rat--an animal model for human hepatitis and hepatocellular carcinoma. (1992) (1)
An integrated transcriptome and epigenome analysis identifies a novel candidate gene for pancreatic cancer (2013) (1)
Analysis of TGF-α/EGFR, HGF/C-MET, TGF-β-RII and P53 expression in human hepatocellular carcinomas (1998) (1)
Abstract LB-173: The Thailand initiative in genomics and expression research for liver cancer (TIGER-LC): Defining novel subtypes of hepatocellular carcinoma and cholangiocarcinoma (2015) (1)
279 Sulf2 Up-Regulates Glypican 3, Promotes FGF Signaling, and Decreases Survival of Patients with Hepatocellular Carcinoma (HCC) (2008) (1)
Related Human Hepatocellular Carcinoma − B Virus Based Recurrence Prediction of Hepatitis − Gene Expression (2008) (1)
Carcinogenicity and mutagenicity of heterocyclic amines in transgenic mouse models. (1999) (1)
Transgenic and Knockout Mouse Models of Liver Cancer (2010) (1)
Lymphoma induction by heterocyclic amines in Eμ-pim-1 transgenic mice (1996) (1)
Biology of Hepatocellular Carcinoma: Past, Present and Beyond (2010) (1)
272 In vitro differentiation of adult liver stem cells into the hepatocytic lineage (2003) (1)
Biochemical Marker Alterations in Hepatic Preneoplasia and Neoplasia (1989) (1)
The MYC Network and Cancer (2010) (1)
Hepatocarcinogenesis Induced −-nitrosodiethylamine N Accelerates Early Stages of Loss of Hepatocyte Growth Factor / c-Met Signaling Pathway (2007) (1)
Genetic signatures shared in embryonic liver development and liver cancer define prognostically relevant subgroups in HCC (2012) (1)
INDUCTION OF N- AND C-HYDROXYLATIONS OF 2-ACETYLAMINOFLUORENE IN RAT HYPERPLASTIC LIVER NODULES AND HEPATOMAS (1980) (1)
Molecular and Cellular Pathobiology CLPTM 1 L Promotes Growth and Enhances Aneuploidy in Pancreatic Cancer Cells (2014) (1)
Isolation and Characterization of a Rat Liver Epithelial Cell Line Resistant to the Antiproliferative Effects of Transforming Growth Factor 0 (Type 1) (1990) (1)
OVARIAN ARYL HYDROCARBON HYDROXYLASE ACTIVITY AND OOCYTE DESTRUCTION (1980) (1)
Induction of drug metabolizing enzymes in man and rat by dichloralphenazone. (1969) (1)
Hepatic Regeneration in Vitamin A-deficient Rats : Changes in the Expression of Transforming Growth Factor a / Epidermal Growth Factor Receptor and Retinoic Acid Receptors a and 1 (2005) (1)
Genome-based predictors for HCC outcomes: a matter of tumor and/or stroma. (2009) (1)
Cancer Stem Cells and Liver Cancer (2010) (1)
Mutagenic activation of 2-acetylaminofluorene and n-hydroxy-2- -acetylaminofluorene by mouse liver and kidney microsomes. Abstr. (1977) (1)
Abstract B89: Identification of dysregulated pathways in pancreatic cancer through gene set and subnetwork enrichment analyses of transcriptome and DNA methylome data. (2012) (1)
Abstract 2460: Tumorigenic potential is independent of sphere phenotype in liver cancer (2011) (0)
HGF modifies but does not inhibit the hepatocarcinogenesis induced by diethylnitrosamine in transgenic mouse models (2002) (0)
CAN-11-3317 1..10 (2012) (0)
Tumor and Stem Cell Biology MYC Activates Stem-like Cell Potential in Hepatocarcinoma by a p 53-Dependent Mechanism (2014) (0)
Decoding the Liver Cancer Genome (2009) (0)
Effects of 12-O-tetradecanoyl-phorbol-13-acetate (TPA) on murine hemopoietic cells in culture (1985) (0)
Transient Expansion of Stem-Like Tumor-Initiating Cells Contributes to Chemoresistance during Anti-Angiogenic Therapies in Hepatocellular Carcinomas (2016) (0)
Role of recombinant cytochromes P4501A1 and P4501A2 in the metabolism and genotoxicity of food derived mutagens. (1990) (0)
Epigenetic based enrichment of cancer stem cells (CSC) in liver cancer: Mechanistic and clinical implications (2010) (0)
What Makes Cirrhosis Irreversible?—Consideration on Structural Changes (2022) (0)
Novel Synthesis and Spectral Characterization of an N-Acetoxyarylamine: N-Acetoxy-2,4-dinitrophenylamine. (1988) (0)
Profiling microRNA expression using sensitive cDNA probes and filter arrays (0)
Ligated SI and W Mice (2007) (0)
The p53 Family Gene Signature Predicts Prognosis in Hepatocellular Carcinoma (2013) (0)
Differential Gene Expression during Hepatocellular Carcinogenesis in c-myc/TGF-alpha Double Transgenic Mice (2003) (0)
Activation of beta-catenin pathway in human hepatocellular carcinoma negatively correlates to CD-44 and AFP expression (2003) (0)
Loss of PDPK1 abrogates resistance to gemcitabine in label-retaining pancreatic cancer cells (2018) (0)
Altered Responsiveness of Rat Liver Epithelial Cells to Transforming Growth Factor /?, following Their Transformation with \-raf (2006) (0)
Flavin-containing monooxygenase activity in human liver microsomes. (1986) (0)
Abstract 4390: The Thailand initiative in genomics and expression research in liver cancer: Race related common molecular subtypes among Asian hepatocellular carcinoma and cholangiocarcinoma identified by integrated genomics (2017) (0)
Identification of viral load signatures for HBV and HCV in human hepatocellular carcinoma (2007) (0)
Mechanistic and therapeutic implications of PDGF-b activation during liver fibrogenesis (2012) (0)
Abstract 4252: Mechanistic and clinical implications of epigenetic modulation in liver cancer stem cells (2010) (0)
HGF/c-Met signaling in hepatocytes protects against progression of chronic liver fibrosis (2011) (0)
770 Sulfatase2 (SULF2) Promotes Angiogenesis in Hepatocellular Carcinoma Partly Through the TGFβ1/Periostin Signaling Pathway (2014) (0)
Global Gene Expression Analysis Demonstrates that Transforming Growth Factor β1 (TGF-β1) Signals Exclusively through Receptor Complexes Involving TGF-β Receptor I and Identifies Numerous Targets of TGF-β Signaling. (2004) (0)
Combined silencing of Ras and Jak/Stat inhibitors results in constitutive activation of Ras and Jak/Stat pathways in human hepatocellular carcinoma (2005) (0)
Acknowledgement to reviewers (2004) (0)
Contents, Vol. 27, 1975 (1975) (0)
Hepatocarcinogenesis Cooperation in ras and myc Importance of c-Hepatoma Cell Line Hep G 2 : Additional Evidence for the Gene in the Human ras Characterization of a Transforming N-Updated (2006) (0)
The role of decorin in liver fibrogenesis (2006) (0)
Abstract 954: Multidrug resistance transcriptome analysis highlights compounds that sensitize resistant hepatocellular carcinoma through increased histone acetylation. (2013) (0)
113 MODULATION OF DEMETHYLATION AND ANTITUMOR POTENTIAL OF ZEBULARINE IN LIVER CANCER (2009) (0)
290 INTEGRATIVE ANALYSIS OF SIRT6 REGULATED GENE NETWORKS IN THE DEVELOPMENT AND PROGRESSION OF HUMAN HEPATOCELLULAR CARCINOMA (2012) (0)
D R U G INTERACTIONS WITH WARFARIN: STUDIES WITH DICHLORALPHENAZONE, CHLORAL (2012) (0)
Mice 1 in the Liver Accelerates Hepatocarcinogenesis in Transgenic β Constitutive Expression of Mature Transforming Growth Factor (2006) (0)
Molecular pathogenesis of liver cancer: early lesions (2009) (0)
Abstract 4297: Selective enrichment of liver cancer stem cell by DNA methyltransferase inhibition (2010) (0)
Abstract 2653: Direct oncogenic reprogramming of adult mouse hepatocytes into cancer stem cells. (2013) (0)
Induction of stemness features and activation of prognostically adverse genomic alterations in hepatocellular carcinoma by field cancerization (2015) (0)
Analysis of transcriptomic changes during cold ischaemia in time-zero biopsies of liver allografts (2015) (0)
Abstract A25: Array‐based comparative genomic hybridization of hepatocellular carcinoma reveals a unique genomic aberration pattern in tumors with poor prognosis (2009) (0)
T-53 Mechanic-based reprogramming of hepatic self-renewing tumor-initiating cells through DNMT1-inhibition (2013) (0)
Abstract 1902: Enrichment of putative cancer stem cells during anti-angiogenic therapies promotes relapse formation in hepatocellular carcinoma (2017) (0)
Effects of hexamethylene bisacetamide onα-fetoprotein, albumin, and transferrin production by two rat hepatoma cell lines (1982) (0)
Outfoxing liver cancer with p19ARF tumor suppressor? (2004) (0)
168 SULF2 Promotes Tumorigenesis of Hepatocellular Carcinoma By Activating the Wnt/β-Catenin Pathway (2009) (0)
Comprar Molecular Genetics of Liver Neoplasia | Wang, Xin Wei | 978-1-4419-608189781441960818 | Springer (2011) (0)
Expression of multidrug resistance-associated protein 1 in hepatocellular carcinoma is associated with aggressive tumor phenotype and can reflect progenitor cell origin (2007) (0)
Abstract 1644: siRNA targeting of cell cycle kinase Wee1 inhibits hepatocullar carconima growthin vitroandin vivo (2011) (0)
Genotoxicity of N*Acetylarylarines in the SalmonellalHepatocyte System (2006) (0)
Activation of hepatic stem-like cells in the tumor microenvironment is a critical determinant of the prognosis of HCC patients (2015) (0)
Abstract 5661: Nanoparticle based combinatorial siRNA therapy against human hepatocellular carcinoma (HCC) . (2013) (0)
Modulation of P16INK4A activity by Hsp90, Cdc37 and CRM1 influences the progression of preneoplastic lesions in rats with different predisposition to liver cancer and the prognosis of human hepatocellular carcinoma (2006) (0)
Epigenetic and post-transcriptional mechanisms are responsible for disruption of the Hippo tumor suppressor pathway in human hepatocellular carcinoma (2011) (0)
A Gene Expression Signature Associated with Overall Survival in Patients with Hepatocellular Carcinoma Suggests a New Treatment Strategy s (2016) (0)
Constitutive over-expression of transforming growth factor-alpha in rat liver epithelial cells leads to increased cell cycling without transformation (1994) (0)
Development in Rats by Two Dimensional Electrophoresis Sequential Analysis of Chemically Induced Hepatoma Updated (2006) (0)
The hepatic tumor microenvironment is important for the CSC phenotype and progression of liver cancer (2015) (0)
Rebuilding the liver with adult hepatic and embryonic stem cells (2007) (0)
Integrative and Functional Genomics of HCC (2010) (0)
Comparison of Hepatic Differentiation Potential between Human ES and iPS Cells (2010) (0)
Molecular and Cellular Pathobiology A Unique Metastasis Gene Signature Enables Prediction of Tumor Relapse in Early-Stage Hepatocellular Carcinoma Patients (2010) (0)
113 Mice with hepatocye-specific disruption of transforming growth factor beta (TGF-β) signaling have enhanced mitogenic response during liver regeneration (2003) (0)
Tumor-initiating cells contribute to acquired chemoresistance during anti-angiogenic therapies in hepatocellular carcinoma (2016) (0)
Abstract 339: Inhibition of NANOG/NANOGP8 downregulates MCL-1 in colorectal cancer (CRC) cells, enhances the efficacy of BH3 mimetics and inhibits clonogenicity (2014) (0)
The liver microenvironment determines the CSC phenotype in hepatocellular carcinomas (2014) (0)
Generation of Induced Pluripotent Stem Cells from Mouse Hepatocytic Lineage Cells (2010) (0)
D 1006 A novel COCH mutation , V 104 del , impairs folding of the LCCL domain of cochlin and causes progressive hearing loss (0)
Abstract #5612: Sulfatase 2 (SULF2) functions as a novel oncogenic protein in hepatocellular carcinoma (HCC) (2009) (0)
P45 SEQUENTIAL TRANSCRIPTOME ANALYSIS OF HUMAN HEPATOCARCINOGENESIS BY RNA SEQUENCING SUPPORTS INTENSIFIED SURVEILLANCE OF EARLY LESIONS TO PREVENT LATE STAGE ACQUISITION OF MALIGNANT TRAITS (2014) (0)
O100 : The hepatic microenvironment induces a CSC phenotype and determines the prognosis of HCC patients (2015) (0)
Genetic Aspects ofToxicity during Development (1976) (0)
Growth and Differentiation of Hepatic Stem Cells (2000) (0)
Oncogenesis in Hepatic α and Transforming Growth Factor myc of c-Oncogenes and Growth Factors in Tumorigenesis : Interaction Transgenic Mouse Model for Synergistic Effects of Nuclear Updated (2006) (0)
A mammalian cell system expressing cytochrome P450 for in situ evaluation of metabolism, genotoxicity, and mutagenicity of xenobiotics (1990) (0)
2893 – Mechanism of N-hydroxy-2-acetylaminofluorene (N-OH-AAF) induced mutagenesis in the Salmonella system (1978) (0)
Identification of early alterations during hepatic oncogenesis in c-Myc/Tgfα transgenic mice by transcriptome analysis (2007) (0)
A new French paradox: HBV vaccination (2009) (0)
Abstract 1983: TP53 mutations in hepatocellular carcinoma: Association with survival and stem cell-like gene expression traits (2010) (0)
Altered expression of beta-globin, transferrin receptor, and ornithine decarboxylase in Friend murine erythroleukemia cells inhibited by alpha-difluoromethylornithine. (1987) (0)
Abstract 2452: Generation of hepatocellular carcinomas with cancer stem cell properties from primary mouse hepatocytes (2011) (0)
Abstract 5646: Allele-specific shRNA to Nanog family members inhibits 3-D growth of colorectal carcinoma through the intrinsic apoptotic pathway (2012) (0)
Liver stem cells**The colour plate section for this chapter appears between pages 274 and 275. (1997) (0)
P69 IMPACT OF EPIGENETIC REPROGRAMMING ON HEPATIC TUMORIGENIC PROPERTIES (2014) (0)
Transgenic mouse models in carcinogenesis: Interaction of c-myc with transforming growth factor α and hepatocyte growth factor in hepato-carcinogenesis (1996) (0)
Relationship between 2-acetylaminofluorene or benzo[a]pyrene metabolism and tumorigenesis in inbred strains of mice. Abstr. (1976) (0)
Comparative functional genomics of autoimmune hepatitis; mechanistic and clinical implications (2013) (0)
750 – POSTNATAL DEVELOPMENT OF ACTIVATION OF PREMUTAGENS IN RABBITS (1978) (0)
Oncogene-specific gene expression signature at preneoplastic stage defines distinct mechanisms of hepatocarcinogenesis in E2f1, c-Myc, and E2f1/c-Myc transgenic mice (2006) (0)
Identification of Common Molecular Subtypes of Asian Hepatocellular Carcinoma and Cholangiocarcinoma. (2017) (0)
Metabolic Activation and Genotoxicity of Heterocyclic Arylamines1 (2006) (0)
Abstract 4927: Translational genomics analyses of cholangiocarcinoma identify patients who may respond to tyrosine kinase inhibitors (2012) (0)
inition of Ubiquitination Modulator COP 1 as a Novel R rapeutic Target in Human Hepatocellular Carcinoma (2010) (0)
Stable Expression of Peroxisomal Fatty Acyl‐CoA Oxidase in Vitro a (1996) (0)
Genotoxicity of NsAcetylarylarines in the SalmonellalHepatocyte System (2016) (0)
1078 MECHANIC-BASED REPROGRAMMING OF HEPATIC SELF-RENEWING TUMOR-INITIATING CELLS THROUGH DNMT1-INHIBITION (2013) (0)
Recombinant mouse cytochromes P1-450 and P3-450: enzymatic characterization of the hemoprotein expressed in human cells infected with recombinant vaccinia virus. (1993) (0)
Application of patient-derived liver cancer cells for personalized treatment approach: from phenotypic characterization to therapeutic target identification (2018) (0)
Dose-dependent enzyme induction. (1973) (0)
Abstract A38: Steatohepatitis-associated hepatocellular carcinoma: Evidence of a keratin-based disease. (2013) (0)
Impact of selective inactivation of transforming growth factor-beta type II receptor gene (TGFBR2) during viral hepatitis (2001) (0)
Transformation of Rat Liver Epithelial Cells during the Spontaneous 1 β Transforming Growth Factor Development of Resistance to the Growth Inhibitory Effects of Updated (2006) (0)
Low Frequency of p 53 Gene Mutation in Tumors Induced by Aflatoxin Nonhuman Primates (2006) (0)
Abstract 5206: Nanog family members are essential for spherogenicity and metastasis in colorectal carcinoma (2011) (0)
819 Conditional ablation of reveals an essential role in liver repair after injury (2003) (0)
Mechanistic studies of acetamide hepatocarcinogenicity. (1986) (0)
949 IDENTIFICATION OF TWO CLINICALLY DISTINCT SUBTYPES IN AUTOIMMUNE HEPATITIS BY COMPARATIVE FUNCTIONAL GENOMICS (2013) (0)
GTF2IRD1 is a Dual-FunctionTranscription Factor that Promotes M Opsin Gene Expression and Suppresses S Opsin Gene Expression in M Cones (2013) (0)
DNA Nitrosodimethylamine and Formation of Adducts with Cellular Mammalian Cells: Metabolic Activation of Stable Expression of Human Cytochrome P450IIE1 in (2006) (0)
Generation of a floxed conditional mutant mouse for the HGF receptor gene c-met Impact of selective inactivation in liver and mammary gland (2001) (0)
Abstract 4249: Shape change induces nitric oxide and stemness in colorectal cancer cells (2010) (0)
Abstract 478: Human solid organ cancers contain stem-like label-retaining cancer cells that undergo asymmetric cell division and have superior tumor initiating capacity (2011) (0)
Transfection ras vH-Breast Cancer Cells following either Estrogen Stimulation or Secreted and Cellular Polypeptide Patterns of MCF-7 Human Updated (2006) (0)
Abstract B20: GLI1 overexpression contributes to HCC recurrence partly through the induction of SNAI1-induced epithelial-to-mesenchymal transition (2011) (0)
Thomas and Autophagy in Hepatocellular Carcinoma mTOR Inhibitors Synergize on Regression , Reversal of Gene Expression (2012) (0)
Genomic and genetic characterization of human Cholangiocarcinoma identifies treatment options for tyrosine kinase inhibitors (2011) (0)
5 – DIRECT SEQUENCE ANALYSIS OF RAT LIVER MEMBRANE GLYCOPROTEINS SEPARATED BY 2D-PAGE (1989) (0)
Abstract 272: Identification of MicroRNAs unique to cancer stem cells by small RNA deep sequencing. (2013) (0)
Selection of transfected cells. Magnetic affinity cell sorting. (1997) (0)
385 MOLECULAR STAGES OF PDGFB DRIVEN LIVER FIBROSIS: LESONS FROM A TRANSGENIC MOUSE MODEL (2012) (0)
Abstract 4818: Validation and clinical utility of a human hepatocellular carcinoma metastasis signature as prognostic classifier (2010) (0)
Abstract 4261: Epigenetic reprogramming affects malignant properties of human liver cancer cells (2012) (0)
HHM: A Dominant Inhibitory Helix-Loop-Helix Protein Associated with Liver-Specific Gene Expression and Liver Stem Cells (2002) (0)
Effective depletion of hepatic cancer stem-like cells by NF-kB mediated inhibiton of histone deacetylases (2014) (0)
U.S.-Japan Cooperative Cancer Research Program Seminar on Carcinogenicity, Mutagenicity, and Metabolism of Heterocyclic Amines (1985) (0)
Transforming Growth Factor- b 1 Recruits Histone Deacetylase 1 to a p130 Repressor Complex in Transgenic Mice in Vivo 1 (2000) (0)
299 Expression of SULF2 by HCC Cells Promotes Tumorigenesis by Inducing Activation, Proliferation and Migration of Hepatic Stellate Cells in the Tumor Microenvironment (2013) (0)
Comprar Liver Under Constant Attack - From Fat to Viruses | Day, C.P. | 9789048127580 | Springer (2009) (0)
Strain differences in mouse ovarian aryl hydrocarbon hydroxylase and ovotoxicity. Abstr. (1977) (0)
Therapeutic Target in Human Hepatocellular Carcinoma Definition of Ubiquitination Modulator COP 1 as a Novel (2010) (0)
Abstract 4181: Comparison of tumorigenic proficiency at different stages of hepatocyte differentiation (2010) (0)
Abstract 1576: Molecular targeting of histone deacetylase 2 for treatment of human hepatocellular carcinoma (2010) (0)
Isolation and characterization of a rat liver epithelial cell line resistant to the antiproliferative effects of transforming growth factor beta (type 1). (1990) (0)
843 SULF1 and SULF2 Correlated Genes in Hepatocellular Carcinoma (HCC) as Revealed by Genome-Wide Gene Expression Microarray Analysis (2010) (0)

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