Sophie E. Jackson
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Researcher ORCID ID = 0000-0002-7470-9800
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Sophie E. Jacksoncomputer-science Degrees
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Computer Science
Sophie E. Jackson's Degrees
- PhD Computer Science Stanford University
- Masters Computer Science Stanford University
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Why Is Sophie E. Jackson Influential?
(Suggest an Edit or Addition)According to Wikipedia, Sophie Elizabeth Jackson is a British biochemist and Professor of Chemical Biology at the University of Cambridge. Her research considers protein folding and assembly, She is interested in topological knots, molecular complexes and the beta barrel protein.
Sophie E. Jackson's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Folding of chymotrypsin inhibitor 2. 1. Evidence for a two-state transition. (1991) (836)
- How do small single-domain proteins fold? (1998) (833)
- Stimulation of the weak ATPase activity of human hsp90 by a client protein. (2002) (235)
- Effect of cavity-creating mutations in the hydrophobic core of chymotrypsin inhibitor 2. (1993) (231)
- Hsp90: structure and function. (2012) (222)
- Protein folding: Defining a “standard” set of experimental conditions and a preliminary kinetic data set of two‐state proteins (2005) (205)
- The co-chaperone p23 arrests the Hsp90 ATPase cycle to trap client proteins. (2006) (193)
- Structure of the transition state for the folding/unfolding of the barley chymotrypsin inhibitor 2 and its implications for mechanisms of protein folding. (1994) (187)
- Ubiquitin chain conformation regulates recognition and activity of interacting proteins (2012) (178)
- Folding of chymotrypsin inhibitor 2. 2. Influence of proline isomerization on the folding kinetics and thermodynamic characterization of the transition state of folding. (1991) (178)
- Factors affecting the physical stability (aggregation) of peptide therapeutics (2017) (139)
- Structure of the hydrophobic core in the transition state for folding of chymotrypsin inhibitor 2: a critical test of the protein engineering method of analysis. (1993) (131)
- The folding and design of repeat proteins: reaching a consensus. (2003) (128)
- Mapping the interactions present in the transition state for unfolding/folding of FKBP12. (1999) (124)
- Structural studies on the co-chaperone Hop and its complexes with Hsp90. (2008) (122)
- A recurring theme in protein engineering: the design, stability and folding of repeat proteins. (2005) (122)
- Knot formation in newly translated proteins is spontaneous and accelerated by chaperonins. (2012) (122)
- Folding studies on a knotted protein. (2005) (121)
- Movement of the position of the transition state in protein folding. (1995) (117)
- Structures and folding pathways of topologically knotted proteins (2011) (110)
- Molecular knots in biology and chemistry (2015) (109)
- Experimental detection of knotted conformations in denatured proteins (2010) (103)
- Ubiquitin folds through a highly polarized transition state. (2005) (102)
- A comparison of the folding of two knotted proteins: YbeA and YibK. (2007) (102)
- Stable intermediate states and high energy barriers in the unfolding of GFP. (2007) (100)
- Hsp70 Forms Antiparallel Dimers Stabilized by Post-translational Modifications to Position Clients for Transfer to Hsp90 (2015) (99)
- Independent ATPase activity of Hsp90 subunits creates a flexible assembly platform. (2004) (96)
- Probing nature's knots: the folding pathway of a knotted homodimeric protein. (2006) (95)
- Hsp90 inhibits α-synuclein aggregation by interacting with soluble oligomers. (2013) (92)
- Folding pathway of FKBP12 and characterisation of the transition state. (1999) (92)
- The effect of Parkinson's-disease-associated mutations on the deubiquitinating enzyme UCH-L1. (2011) (91)
- Local and long-range stability in tandemly arrayed tetratricopeptide repeats. (2005) (89)
- Biochemical and structural studies of the interaction of Cdc37 with Hsp90. (2004) (77)
- Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity (2018) (75)
- Exploring knotting mechanisms in protein folding (2008) (75)
- Is an intermediate state populated on the folding pathway of ubiquitin? (2004) (73)
- Knotting and unknotting of a protein in single molecule experiments (2016) (71)
- 19F NMR studies of the native and denatured states of green fluorescent protein. (2006) (68)
- Knotted fusion proteins reveal unexpected possibilities in protein folding. (2008) (68)
- Ubiquitin: a small protein folding paradigm. (2006) (67)
- Contribution of long-range electrostatic interactions to the stabilization of the catalytic transition state of the serine protease subtilisin BPN'. (1993) (64)
- How to fold intricately: using theory and experiments to unravel the properties of knotted proteins. (2016) (64)
- Heterogeneity and dynamics in the assembly of the Heat Shock Protein 90 chaperone complexes (2011) (63)
- The folding, stability and conformational dynamics of beta-barrel fluorescent proteins. (2009) (63)
- Mechanistic studies on Hsp90 inhibition by ansamycin derivatives. (2007) (57)
- Understanding the folding of GFP using biophysical techniques (2006) (56)
- Untangling the folding mechanism of the 52‐knotted protein UCH‐L3 (2009) (55)
- Mechanistic insights into the folding of knotted proteins in vitro and in vivo. (2015) (53)
- Hsp90: from structure to phenotype (2004) (53)
- Does trifluoroethanol affect folding pathways and can it be used as a probe of structure in transition states? (1999) (51)
- The Dimerization of an α/β-Knotted Protein Is Essential for Structure and Function (2007) (51)
- Context-dependent nature of destabilizing mutations on the stability of FKBP12. (1998) (50)
- Conformational dynamics of the molecular chaperone Hsp90 in complexes with a co-chaperone and anticancer drugs. (2007) (49)
- Evidence of an intermediate and parallel pathways in protein unfolding from single-molecule fluorescence. (2008) (47)
- Hsp90 reaches new heights (2003) (42)
- Engineering and design. (2003) (42)
- The folding pathway of ubiquitin from all-atom molecular dynamics simulations. (2004) (40)
- Energetic and structural analysis of the role of tryptophan 59 in FKBP12. (2003) (36)
- The Knotted Protein UCH-L1 Exhibits Partially Unfolded Forms under Native Conditions that Share Common Structural Features with Its Kinetic Folding Intermediates. (2016) (36)
- Effect of low-level BCR-ABL1 kinase domain mutations identified by next-generation sequencing in patients with chronic myeloid leukaemia: a population-based study. (2019) (35)
- The discovery and development of the green fluorescent protein, GFP. (2009) (32)
- Contribution of residues in the reactive site loop of chymotrypsin inhibitor 2 to protein stability and activity. (1994) (32)
- Distinct Mechanisms of Calmodulin Binding and Regulation of Adenylyl Cyclases 1 and 8 (2012) (30)
- Exploring sequence/folding space: folding studies on multiple hydrophobic core mutants of ubiquitin. (2004) (29)
- Faculty of 1000 evaluation for Cytosolic proteostasis through importing of misfolded proteins into mitochondria. (2017) (28)
- The dimerization of an alpha/beta-knotted protein is essential for structure and function. (2007) (24)
- Letter to the Editor: 1H, 15N and 13C backbone assignment of the Green Fluorescent Protein (GFP) (2003) (23)
- A pH-Induced Switch in Human Glucagon-like Peptide-1 Aggregation Kinetics. (2016) (23)
- A high-throughput fluorescence chemical denaturation assay as a general screen for protein-ligand binding. (2011) (23)
- Folding Study of Venus Reveals a Strong Ion Dependence of Its Yellow Fluorescence under Mildly Acidic Conditions* (2009) (22)
- Comparative analysis of the folding dynamics and kinetics of an engineered knotted protein and its variants derived from HP0242 of Helicobacter pylori (2015) (22)
- Destabilised mutants of ubiquitin gain equal stability in crowded solutions. (2007) (20)
- The extremely slow‐exchanging core and acid‐denatured state of green fluorescent protein (2008) (20)
- Folding and stability of the ligand‐binding domain of the glucocorticoid receptor (2002) (20)
- Spin relaxation effects in photochemically induced dynamic nuclear polarization spectroscopy of nuclei with strongly anisotropic hyperfine couplings. (2007) (19)
- Protein denaturation and protein:drugs interactions from intrinsic protein fluorescence measurements at the nanolitre scale. (2010) (18)
- The AAA+ protease ClpXP can easily degrade a 31 and a 52-knotted protein (2019) (17)
- Use of protein engineering techniques to elucidate protein folding pathways. (2008) (15)
- Protein stability: experimental data from protein engineering (1993) (14)
- Native-state dynamics of the ubiquitin family: implications for function and evolution (2005) (14)
- Backbone NMR assignments of a topologically knotted protein in urea-denatured state (2014) (13)
- Characterization of the Folding of a 52-Knotted Protein Using Engineered Single-Tryptophan Variants. (2016) (12)
- Bayesian inference of accurate population sizes and FRET efficiencies from single diffusing biomolecules. (2014) (10)
- Chaperome screening leads to identification of Grp94/Gp96 and FKBP4/52 as modulators of the α‐synuclein‐elicited immune response (2016) (10)
- Backbone assignments of the 26 kDa neuron-specific ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1) (2010) (10)
- Backbone 1H, 13C and 15N assignments of YibK and avariant containing a unique cysteine residue at C-terminus in 8 M urea-denatured states [corrected]. (2014) (9)
- The Folding, Stability and Conformational Dynamics of β‐Barrel Fluorescent Proteins (2009) (8)
- Fast folding of a four-helical bundle protein. (2002) (7)
- NMR Studies of the Native and Denatured States of Green Fluorescent Protein (7)
- Reactivation of ethyl methylphosphonylated eel acetylcholinesterase in vitro by 2PAM, H16, and a series of nonquaternary alpha-ketothiohydroximates. (1985) (6)
- The Dimerization of an a / b-Knotted Protein Is Essential for Structure and Function (6)
- The Amyloid Fibril-Forming β-Sheet Regions of Amyloid β and α-Synuclein Preferentially Interact with the Molecular Chaperone 14-3-3ζ (2021) (4)
- Why are there knots in proteins? (2020) (4)
- A Comparison of Experimental and Computational Methods for Mapping the Interactions Present in the Transition State for Folding of FKBP12 (2001) (4)
- How to fold intricately: using theory and experiments to unravel the properties of knotted proteins (2016) (4)
- Faculty Opinions recommendation of A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules. (2006) (4)
- pyFRET: A Python Library for Single Molecule Fluorescence Data Analysis (2014) (4)
- Comparison of three enzymatic models for evaluation of reactivators of organophosphorus ester inhibited acetylcholinesterase. (1984) (3)
- Clinical Intervention Using NGS-Based Kinase Domain Mutation Testing in CML Patients (2018) (3)
- Characterising the Folding Pathways of Topologically Knotted Proteins (2012) (3)
- Backbone NMR assignments of a topologically knotted protein in urea-denatured state (2014) (3)
- Backbone NMR assignments of a topologically knotted protein in urea-denatured state (2013) (2)
- Prospective Evaluation of ABL Kinase Domain Mutational Analysis By Next-Generation-Sequencing in Newly Diagnosed CP CML Patients Undergoing First-Line Treatment with Nilotinib Alone or Nilotinib + Pegylated Interferon-α2a in a Prospective Phase III Trial (2019) (2)
- Low-temperature study of the plastocyanin–ferricyanide electron-transfer reaction in aqueous methanol reveals an unusual energy barrier (1988) (2)
- The solution to multiple structures. (2008) (2)
- Interconversion of Unexpected Thiol States Affects the Stability, Structure, and Dynamics of Antibody Engineered for Site-Specific Conjugation. (2021) (1)
- Toward Rapid Aspartic Acid Isomer Localization in Therapeutic Peptides Using Cyclic Ion Mobility Mass Spectrometry (2022) (1)
- Tau-Hsp70 interaction on the single molecule level (2013) (1)
- Knots in soft condensed matter (2015) (1)
- An Independent Method for the Analysis of Protein Folding Kinetics from All-atom Molecular Dynamics Simulations (2005) (1)
- FK506-binding protein mutant WF59 complexed with Rapamycin (2006) (1)
- Crystal structure of a multiple hydrophobic core mutant of ubiquitin (2004) (0)
- Experimental studies on the folding pathways of knotted proteins (2013) (0)
- Faculty Opinions recommendation of Ever-fluctuating single enzyme molecules: Michaelis-Menten equation revisited. (2006) (0)
- Interconversion of unexpected thiol states affects stability, structure and dynamics in engineered antibody for site-specific conjugation (2020) (0)
- Faculty Opinions recommendation of Probing gene expression in live cells, one protein molecule at a time. (2006) (0)
- BCR-ABL1 kinase domain mutation screening using next generation sequencing in CML and Ph plus ALL patients (2018) (0)
- Interim Analysis of a Prospective Multicentre Study Using Next Generation Sequencing for Kinase Domain Mutational Analysis in CML Patients on First or Subsequent TKI Therapy (2019) (0)
- A pH-induced switch in GLP-1 aggregation kinetics (2016) (0)
- ofthe barley chymotrypsin inhibitor 2anditsimplications for mechanisms ofprotein folding (1994) (0)
- Faculty Opinions recommendation of Regulation of α-synuclein by chaperones in mammalian cells. (2020) (0)
- All-in-one disulfide bridging enables the generation of antibody conjugates with modular cargo loading (2022) (0)
- Faculty Opinions recommendation of Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation. (2018) (0)
- Backbone NMR assignments of a topologically knotted protein in urea-denatured state (2013) (0)
- Mechanistic insights into the rational design of masked antibodies (2022) (0)
- Accurate Intramolecular Distances by Single Molecule Confocal Spectroscopy: A Monte Carlo Markov Chain Analysis of Fluorescence Data from Freely Diffusing Biomolecules (2013) (0)
- Faculty Opinions recommendation of Crystal structure of an ancient protein: evolution by conformational epistasis. (2007) (0)
- Faculty Opinions recommendation of Residues in substrate proteins that interact with GroEL in the capture process are buried in the native state. (2006) (0)
- The AAA+ protease ClpXP can easily degrade a 31 and a 52-knotted protein (2019) (0)
- Glucagon-like peptide 1 aggregates into low molecular weight oligomers off-pathway to fibrillation. (2023) (0)
- Faculty Opinions recommendation of Extreme disorder in an ultrahigh-affinity protein complex. (2018) (0)
- Paper Alert Chosen by (2000) (0)
- Green Fluorescent Protein issue Reviewing the latest developments in the science of green fluorescent protein (2009) (0)
- Protein Folding, Engineering of (2005) (0)
- Wales Andrew Wheatley Paul Wood Peter Wothers Dominic Wright An introduction to Cambridge Chemistry Academic staff (2012) (0)
- Faculty Opinions recommendation of Real-time monitoring of protein complexes reveals their quaternary organization and dynamics. (2008) (0)
- Erratum to: Backbone 1H, 13C and 15N assignments of YibK and a variant containing a unique cysteine residue at C-terminus in 8 M urea-denatured states (2013) (0)
- Faculty Opinions recommendation of Structural basis for the antifolding activity of a molecular chaperone. (2016) (0)
- Faculty Opinions recommendation of A defined structural unit enables de novo design of small-molecule-binding proteins. (2020) (0)
- Single Molecule Studies Of Ubiquitin Unfolding (2009) (0)
- Faculty Opinions recommendation of Proteins evolve on the edge of supramolecular self-assembly. (2017) (0)
- Directed differentiation of embryonic stem cells toward pancreatic endoderm. 2.115 (2006) (0)
- Tau-Hsp70 interaction on the single molecule level (2013) (0)
- Energy efficiency the gordian knot of EU and global climate policy: A scenario-based policy analysis for the EU (2017) (0)
- Ubiquitin: A Small Protein Folding Paradigm (2006) (0)
- The latest in Engineering and design: the 2005 collection (2005) (0)
- Faculty Opinions recommendation of The folding cooperativity of a protein is controlled by its chain topology. (2010) (0)
- Marcus-like translocation kinetics of a knotted protein. (2023) (0)
- Faculty Opinions recommendation of Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins. (2008) (0)
- Erratum to: Backbone 1H, 13C and 15N assignments of YibK and a variant containing a unique cysteine residue at C-terminus in 8 M urea-denatured states (2014) (0)
- The effect of HNE modification on the structure and function of the neuronal protein UCH-L: Links to neurodegenerative disease (2012) (0)
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