Squire Booker
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Chemist and biochemist
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Squire Bookerbiology Degrees
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Biochemistry
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#2551
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Chemistry Biology
Squire Booker's Degrees
- Bachelors Chemistry University of North Carolina at Chapel Hill
- PhD Chemistry University of North Carolina at Chapel Hill
Why Is Squire Booker Influential?
(Suggest an Edit or Addition)According to Wikipedia, Squire Booker is an American biochemist at Penn State University. Booker directs an interdisciplinary chemistry research program related to fields of biochemistry, enzymology, protein chemistry, natural product biosynthesis, and mechanisms of radical dependent enzymes. He is an associate editor for the American Chemical Society Biochemistry Journal, is a Hughes Medical Institute Investigator, and an Eberly Distinguished Chair in Science at Penn State University.
Squire Booker's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- A Radically Different Mechanism for S-Adenosylmethionine–Dependent Methyltransferases (2011) (194)
- A model for the role of multiple cysteine residues involved in ribonucleotide reduction: amazing and still confusing. (1992) (183)
- Substrate positioning controls the partition between halogenation and hydroxylation in the aliphatic halogenase, SyrB2 (2009) (169)
- Radical S-Adenosylmethionine Enzymes in Human Health and Disease. (2016) (161)
- Lipoyl synthase requires two equivalents of S-adenosyl-L-methionine to synthesize one equivalent of lipoic acid. (2004) (159)
- Ribonucleotide reductases: radical enzymes with suicidal tendencies. (1995) (150)
- Structural Basis for Methyl Transfer by a Radical SAM Enzyme (2011) (150)
- Mechanistic Diversity of Radical S-Adenosylmethionine (SAM)-dependent Methylation* (2014) (143)
- Detection of formate, rather than carbon monoxide, as the stoichiometric coproduct in conversion of fatty aldehydes to alkanes by a cyanobacterial aldehyde decarbonylase. (2011) (138)
- Evidence for only oxygenative cleavage of aldehydes to alk(a/e)nes and formate by cyanobacterial aldehyde decarbonylases. (2012) (135)
- Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily. (2008) (129)
- Mechanistic investigations of lipoic acid biosynthesis in Escherichia coli: both sulfur atoms in lipoic acid are contributed by the same lipoyl synthase polypeptide. (2005) (125)
- Conversion of fatty aldehydes to alka(e)nes and formate by a cyanobacterial aldehyde decarbonylase: cryptic redox by an unusual dimetal oxygenase. (2011) (122)
- Escherichia coli lipoyl synthase binds two distinct [4Fe-4S] clusters per polypeptide. (2004) (118)
- Anaerobic functionalization of unactivated C-H bonds. (2009) (107)
- In vitro characterization of AtsB, a radical SAM formylglycine-generating enzyme that contains three [4Fe-4S] clusters. (2008) (100)
- X-ray structure of an AdoMet radical activase reveals an anaerobic solution for formylglycine posttranslational modification (2013) (100)
- Coenzyme B12-dependent ribonucleotide reductase: evidence for the participation of five cysteine residues in ribonucleotide reduction. (1994) (99)
- Self-sacrifice in radical S-adenosylmethionine proteins. (2007) (98)
- Insight into the polar reactivity of the onium chalcogen analogues of S-adenosyl-L-methionine. (2004) (96)
- S-Adenosylmethionine-dependent reduction of lysine 2,3-aminomutase and observation of the catalytically functional iron-sulfur centers by electron paramagnetic resonance. (1998) (92)
- Mössbauer spectroscopy of Fe/S proteins. (2015) (89)
- RlmN and AtsB as models for the overproduction and characterization of radical SAM proteins. (2012) (86)
- Destruction and reformation of an iron-sulfur cluster during catalysis by lipoyl synthase (2017) (83)
- Auxiliary iron-sulfur cofactors in radical SAM enzymes. (2015) (83)
- Atlas of the Radical SAM Superfamily: Divergent Evolution of Function Using a "Plug and Play" Domain. (2018) (82)
- Cloning, sequencing, and expression of the adenosylcobalamin-dependent ribonucleotide reductase from Lactobacillus leichmannii. (1993) (80)
- Cyanobacterial alkane biosynthesis further expands the catalytic repertoire of the ferritin-like 'di-iron-carboxylate' proteins. (2011) (76)
- Direct FeS cluster involvement in generation of a radical in lysine 2,3-aminomutase. (2000) (75)
- Radical mechanisms of S-adenosylmethionine-dependent enzymes. (2001) (74)
- A high-throughput screen for quorum-sensing inhibitors that target acyl-homoserine lactone synthases (2013) (73)
- A consensus mechanism for Radical SAM-dependent dehydrogenation? BtrN contains two [4Fe-4S] clusters. (2010) (70)
- Crystallographic snapshots of sulfur insertion by lipoyl synthase (2016) (70)
- Consecutive radical S-adenosylmethionine methylations form the ethyl side chain in thienamycin biosynthesis (2015) (70)
- Characterization of RimO, a new member of the methylthiotransferase subclass of the radical SAM superfamily. (2009) (68)
- Identification and function of auxiliary iron-sulfur clusters in radical SAM enzymes. (2012) (65)
- Substrate-triggered addition of dioxygen to the diferrous cofactor of aldehyde-deformylating oxygenase to form a diferric-peroxide intermediate. (2013) (64)
- Spectroscopic and Electrochemical Characterization of the Iron-Sulfur and Cobalamin Cofactors of TsrM, an Unusual Radical S-Adenosylmethionine Methylase. (2016) (64)
- Mechanistic and functional versatility of radical SAM enzymes (2010) (63)
- X-ray analysis of butirosin biosynthetic enzyme BtrN redefines structural motifs for AdoMet radical chemistry (2013) (61)
- Cfr and RlmN contain a single [4Fe-4S] cluster, which directs two distinct reactivities for S-adenosylmethionine: methyl transfer by SN2 displacement and radical generation. (2011) (58)
- Studies on the catalysis of carbon-cobalt bond homolysis by ribonucleoside triphosphate reductase: evidence for concerted carbon-cobalt bond homolysis and thiyl radical formation. (1999) (53)
- Further characterization of Cys-type and Ser-type anaerobic sulfatase maturating enzymes suggests a commonality in the mechanism of catalysis. (2013) (52)
- Crystallographic capture of a radical S-adenosylmethionine enzyme in the act of modifying tRNA (2016) (52)
- Isotope and elemental effects indicate a rate-limiting methyl transfer as the initial step in the reaction catalyzed by Escherichia coli cyclopropane fatty acid synthase. (2004) (51)
- Lysine 2,3-aminomutase and trans-4,5-dehydrolysine: characterization of an allylic analogue of a substrate-based radical in the catalytic mechanism. (2000) (51)
- Rapid Reduction of the Diferric-Peroxyhemiacetal Intermediate in Aldehyde-Deformylating Oxygenase by a Cyanobacterial Ferredoxin: Evidence for a Free-Radical Mechanism. (2015) (50)
- Evidence for a Catalytically and Kinetically Competent Enzyme–Substrate Cross-Linked Intermediate in Catalysis by Lipoyl Synthase (2014) (47)
- Identification of an intermediate methyl carrier in the radical S-adenosylmethionine methylthiotransferases RimO and MiaB. (2013) (47)
- Escherichia coli L-Serine Deaminase Requires a [4Fe-4S] Cluster in Catalysis* (2004) (47)
- Enhanced Solubilization of Class B Radical S-Adenosylmethionine Methylases by Improved Cobalamin Uptake in Escherichia coli. (2018) (46)
- Escherichia coli quinolinate synthetase does indeed harbor a [4Fe-4S] cluster. (2005) (45)
- NosN, a Radical S-Adenosylmethionine Methylase, Catalyzes Both C1 Transfer and Formation of the Ester Linkage of the Side-Ring System during the Biosynthesis of Nosiheptide. (2017) (45)
- A Substrate Radical Intermediate in Catalysis by the Antibiotic Resistance Protein Cfr (2013) (41)
- Unraveling the pathway of lipoic acid biosynthesis. (2004) (37)
- The activity of Escherichia coli cyclopropane fatty acid synthase depends on the presence of bicarbonate. (2005) (36)
- Characterization of a Cross-Linked Protein–Nucleic Acid Substrate Radical in the Reaction Catalyzed by RlmN (2014) (36)
- Electrochemical Resolution of the [4Fe-4S] Centers of the AdoMet Radical Enzyme BtrN: Evidence of Proton Coupling and an Unusual, Low-Potential Auxiliary Cluster. (2015) (36)
- Expression, purification, and physical characterization of Escherichia coli lipoyl(octanoyl)transferase. (2005) (35)
- Efficient delivery of long-chain fatty aldehydes from the Nostoc punctiforme acyl-acyl carrier protein reductase to its cognate aldehyde-deformylating oxygenase. (2015) (34)
- Characterization of quinolinate synthases from Escherichia coli, Mycobacterium tuberculosis, and Pyrococcus horikoshii indicates that [4Fe-4S] clusters are common cofactors throughout this class of enzymes. (2008) (34)
- Faculty Opinions recommendation of Biosynthesis and recycling of nicotinamide cofactors in mycobacterium tuberculosis. An essential role for NAD in nonreplicating bacilli. (2008) (33)
- Rerouting the Pathway for the Biosynthesis of the Side Ring System of Nosiheptide: The Roles of NosI, NosJ, and NosK (2017) (28)
- Structural basis for non-radical catalysis by TsrM, a radical-SAM methylase (2020) (26)
- Efficient methylation of C2 in l-tryptophan by the cobalamin-dependent radical S-adenosylmethionine methylase TsrM requires an unmodified N1 amine (2017) (25)
- Methanogenesis marker protein 10 (Mmp10) from Methanosarcina acetivorans is a radical S-adenosylmethionine methylase that unexpectedly requires cobalamin (2019) (24)
- Capturing Intermediates in the Reaction Catalyzed by NosN, a Class C Radical S-Adenosylmethionine Methylase Involved in the Biosynthesis of the Nosiheptide Side-Ring System. (2019) (21)
- Stereochemical and Mechanistic Investigation of the Reaction Catalyzed by Fom3 from Streptomyces fradiae, a Cobalamin-Dependent Radical S-Adenosylmethionine Methylase. (2018) (21)
- Radical SAM enzymes and radical enzymology. (2012) (20)
- Radical intermediates in the reaction of lysine 2,3-aminomutase (1999) (19)
- TsrM as a Model for Purifying and Characterizing Cobalamin-Dependent Radical S-Adenosylmethionine Methylases. (2017) (18)
- Trifluoroselenomethionine: A New Unnatural Amino Acid (2016) (18)
- Expression in yeast and purification of functional macrophage nitric oxide synthase. Evidence for cysteine-194 as iron proximal ligand. (1996) (17)
- Characterization of Lipoyl Synthase from Mycobacterium tuberculosis. (2016) (17)
- The First Step in Catalysis of the Radical S-Adenosylmethionine Methylthiotransferase MiaB Yields an Intermediate with a [3Fe-4S]0-like Auxiliary Cluster. (2020) (17)
- Ferredoxins as interchangeable redox components in support of MiaB, a radical S‐adenosylmethionine methylthiotransferase (2019) (16)
- Structural basis for tRNA methylthiolation by the radical SAM enzyme MiaB (2021) (16)
- Transformations of the FeS Clusters of the Methylthiotransferases MiaB and RimO, Detected by Direct Electrochemistry (2016) (16)
- Characterization of a Radical Intermediate in Lipoyl Cofactor Biosynthesis. (2015) (15)
- Structure of a B12-dependent radical SAM enzyme in carbapenem biosynthesis (2022) (15)
- The A-type domain in Escherichia coli NfuA is required for regenerating the auxiliary [4Fe–4S] cluster in Escherichia coli lipoyl synthase (2018) (15)
- Biochemical Approaches for Understanding Iron-Sulfur Cluster Regeneration in Escherichia coli Lipoyl Synthase During Catalysis. (2018) (14)
- Structure of Quinolinate Synthase from Pyrococcus horikoshii in the Presence of Its Product, Quinolinic Acid. (2016) (13)
- How synonymous mutations alter enzyme structure and function over long time scales (2021) (13)
- Lipoic Acid Biosynthesis (2008) (11)
- Parsing redox potentials of five ferredoxins found within Thermotoga maritima (2019) (10)
- Stereochemical Course of the Reaction Catalyzed by RimO, a Radical SAM Methylthiotransferase. (2016) (10)
- Understanding the role of electron donors in the reaction catalyzed by Tsrm, a cobalamin-dependent radical S-adenosylmethionine methylase (2019) (9)
- Lipoic Acid Biosynthesis and Enzymology (2010) (9)
- Regulation of the activity of Escherichia coli quinolinate synthase by reversible disulfide-bond formation. (2008) (9)
- Ribonucleotide reductases: radical enzymes with suicidal tendencies. (1993) (9)
- Stuffed Methyltransferase Catalyzes the Penultimate Step of Pyochelin Biosynthesis. (2018) (8)
- Using Peptide Mimics to Study the Biosynthesis of the Side-Ring System of Nosiheptide. (2018) (8)
- Biochemistry: The ylide has landed (2013) (8)
- Discovery, structure and mechanism of a tetraether lipid synthase (2022) (7)
- An Unexpected Species Determined by X-ray Crystallography that May Represent an Intermediate in the Reaction Catalyzed by Quinolinate Synthase. (2019) (6)
- The Biosynthesis of Lipoic Acid (2020) (5)
- The role of iron-sulfur clusters in the biosynthesis of the lipoyl cofactor (2014) (5)
- Investigation of Solvent Hydron Exchange in the Reaction Catalyzed by the Antibiotic Resistance Protein, Cfr (2016) (5)
- Functional spectrum and specificity of mitochondrial ferredoxins FDX1 and FDX2 (2022) (5)
- Structural basis for carbapenam C-alkylation by TokK, a B12-dependent radical SAM enzyme (2021) (4)
- Cloning, sequencing, expression, and characterization of the adenosylcobalamin-dependent ribonucleotide reductase from Lactobacillus leichmannii (1994) (3)
- Adenosylcobalamin-Dependent Ribonucleotide Reductases: Still Amazing but No Longer Confusing (2007) (3)
- The Expanding Role of Methyl-Coenzyme M Reductase in the Anaerobic Functionalization of Alkanes. (2019) (3)
- In Vitro Demonstration of Human Lipoyl Synthase Catalytic Activity in the Presence of NFU1 (2022) (2)
- Characterization of Radical S-adenosylmethionine Enzymes and Intermediates in their Reactions by Continuous Wave and Pulse Electron Paramagnetic Resonance Spectroscopies (2017) (2)
- A (Re)Discovery of the Fom3 Substrate. (2018) (2)
- Characterization of LipS1 and LipS2 from Thermococcus kodakarensis: Proteins Annotated as Biotin Synthases, which Together Catalyze Formation of the Lipoyl Cofactor (2022) (1)
- [FeFe]-Hydrogenase: Defined Lysate-Free Maturation Reveals a Key Role for Lipoyl-H-Protein in DTMA Ligand Biosynthesis. (2022) (1)
- Enzymology: Radical break-up, blissful make-up. (2011) (1)
- Twenty Years of Radical SAM! The Genesis of the Superfamily (2022) (1)
- Enzymatic Free Radical Reactions (2005) (1)
- Analysis of RNA methylation by phylogenetically diverse Cfr radical SAM enzymes reveals an iron-binding accessory domain in a clostridial enzyme. (2019) (1)
- Radical S-Adenosylmethionine Methylases (2020) (1)
- Faculty Opinions recommendation of Lipoic acid synthesis and attachment in yeast mitochondria. (2009) (0)
- Dependent Methyltransferases −-Adenosylmethionine S A Radically Different Mechanism for (2014) (0)
- Identification of Mechanistic Targets for Optimization of a Cyanobacterial Hydrocarbon Production Bioprocess (2016) (0)
- Crystallographic Capture of Quinolinate Synthase (NadA) from Pyrococcus horikoshii in its Substrates and Product-Bound States (2016) (0)
- The structure of MiaB with pentasulfide bridge (2021) (0)
- MiaB in the complex with 5'-deoxyadenosine, methionine and RNA (2021) (0)
- The biosynthesis of lipoic acid: A saga of death, destruction, and rebirth (2022) (0)
- Using peptide substrate analogs to characterize a radical intermediate in NosN catalysis. (2022) (0)
- Crystal structure of Caulobacter crescentus ThiC complexed with imidazole ribonucleotide (2008) (0)
- Investigation of the Radical SAM Methylthiotransferase MiaB Reaction Mechanism (2015) (0)
- Arthur C. Cope Scholar Awards and Eli Lilly Award (2012) (0)
- Biochemical Approaches to Probe the Role of the Auxiliary Iron-Sulfur Cluster of Lipoyl Synthase from Mycobacterium Tuberculosis. (2021) (0)
- Radical‐dependent mechanisms of posttranslational and posttranscriptional modification (2011) (0)
- Overview and Introduction (2020) (0)
- X-ray crystal structure of C118A RlmN with cross-linked tRNA purified from Escherichia coli (2016) (0)
- X-ray structure of RlmN from Escherichia coli in complex with S-adenosylmethionine (2011) (0)
- Electrochemical Investigation of the Radical SAM Enzyme, BtrN from Bacillus Circulans (2013) (0)
- Crystal structure of M. tuberculosis lipoyl synthase at 1.64 A resolution (2016) (0)
- An Unexpected Intermediate in the Reaction Catalyzed by Quinolinate Synthase (2019) (0)
- Radical strategies for biological methylation (2017) (0)
- Characterization of A Novel S‐adenosylmethionine‐dependent Methylase by Electron Paramagnetic Resonance and Mössbauer Spectroscopies (2018) (0)
- Spectroscopic and Electrochemical Characterization of a Unique Radical S‐Adenosylmethionine Methylase (2016) (0)
- Structural characterization of cobalamin-dependent radical S-adenosylmethionine methylases. (2022) (0)
- Function, timing and catalytic mechanism of NosN, a class C radical SAM methylase involved in the biosynthesis of nosiheptide's side‐ring system (2019) (0)
- Identification of an Intermediate Methyl Carrier and the Stereochemical Outcomes of H‐atom Abstraction and Methylthiolation by the Radical SAM Enzyme RimO (2015) (0)
- Structure of radical S-adenosylmethionine methyltransferase, TsrM, from Kitasatospora setae with tryptophan substrate and SAM analog (aza-SAM) bound (2020) (0)
- Electrochemical investigation of a radical sadenosylmethionine enzyme: BtrN from Bacillus circulans (2013) (0)
- Roles of Conserved Cysteinyl Residues in the Radical SAM Methyltransferases RlmN and Cfr (2011) (0)
- Faculty Opinions recommendation of Mechanistic and functional insights into fatty acid activation in Mycobacterium tuberculosis. (2009) (0)
- Faculty Opinions recommendation of Identification of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in bacteria. (2009) (0)
- Crystal structure of Caulobacter crescentus ThiC (2008) (0)
- Crystal structure of M. tuberculosis lipoyl synthase at 2.28 A resolution (2016) (0)
- Unraveling the Biosynthesis of Dimethyl Indolic Acid, A Key Moiety of the Antibacterial Nosiheptide (2015) (0)
- Crystallographic snapshots of TsrM, a cobalamin-dependent radical S-adenosylmethionine methylase (2021) (0)
- The Biosynthesis of the Indolic Acid Moiety from the Antibiotic Nosiheptide (2016) (0)
- Structure of a B12-dependent radical SAM enzyme in carbapenem biosynthesis (2022) (0)
- Structure of radical S-adenosylmethionine methyltransferase, TsrM, from Kitasatospora setae with cobalamin and [4Fe-4S] cluster bound (2020) (0)
- Structure of a Key Intermediate in the Reaction Catalyzed by the Dual Specificity Methylase RlmN (2016) (0)
- Unraveling the Biosynthesis of the Essential Lipoyl Cofactor in Staphylococcus aureus (2019) (0)
- X-ray crystal structure of C118A RlmN from Escherichia coli with cross-linked in vitro transcribed tRNA (2016) (0)
- Isolation and characterization of an intermediate in lipoyl cofactor biosynthesis (2011) (0)
- X-ray structure of RlmN from Escherichia coli (2011) (0)
- Bridging a gap in iron-sulfur cluster assembly (2015) (0)
- Never stop questioning (2007) (0)
- Evidence for the Sacrificial Role of the Auxiliary [4Fe‐4S] Cluster of Lipoyl Synthase (2015) (0)
- Discovery, structure and mechanism of a tetraether lipid synthase (2022) (0)
- Methylated MiaB in the complex with 5'-deoxyadenosine, methionine and RNA (2021) (0)
- Happy Birthday ACS Bio & Med Chem Au! (2022) (0)
- Crystal structure of Caulobacter crescentus ThiC complexed with HMP-P (2008) (0)
- Crystal Structure of NosK from Streptomyces actuosus (2017) (0)
- FDX1 regulates cellular protein lipoylation through direct binding to LIAS (2023) (0)
- Proteins Involved in Converting Fatty Acids to Fuel (2011) (0)
- MiaB in the complex with s-adenosyl-L-homocysteine and RNA (2021) (0)
- Crystal structure of M. tuberculosis lipoyl synthase with 6-thiooctanoyl peptide intermediate (2016) (0)
- Crystallographic snapshots of TsrM, a radical S‐adenosylmethionine enzyme whose reaction is not so radical (2020) (0)
- Abstract 1343: A Defined Lysate-Free in vitro [FeFe]-Hydrogenase Maturation (2023) (0)
- Welcome to ACS Bio & Med Chem Au (2021) (0)
- A structural study of quinolinate synthase, a key enzyme in bacterial NAD+ biosynthesis (2017) (0)
- MiaB in the complex with s-adenosylmethionine and RNA (2021) (0)
- is directed to particular targets by adaptor proteins. (2015) (0)
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