Stanley J. Korsmeyer

Stanley J. Korsmeyer's AcademicInfluence.com Rankings

Medical

#321

World Rank

#465

Historical Rank

#141

USA Rank

Oncology

World Rank

Historical Rank

USA Rank

medical Degrees

Download Badge

Medical

Stanley J. Korsmeyer's Degrees

Doctorate Medicine University of Chicago
PhD Biochemistry University of Chicago

Why Is Stanley J. Korsmeyer Influential?

(Suggest an Edit or Addition)

According to Wikipedia, Stanley Joel Korsmeyer was an American research scientist known for his work on B cell lymphomas and apoptosis. Born and educated in the US state of Illinois, Korsmeyer spent most of his career as a professor at Washington University School of Medicine and later the Dana–Farber Cancer Institute. He rose to prominence in the early 1980s as a research fellow at the National Cancer Institute. There he co-discovered the genetic cause of most cases of the cancer follicular lymphoma – the misregulation of the gene Bcl-2. Korsmeyer went on to start his own laboratory at Washington University in St. Louis, further studying the role of Bcl-2 in cell biology. His group's work expanded the paradigm of cancer-causing genes, providing the first example of how interfering with programmed cell death could lead to cancer development. Korsmeyer authored over 250 scientific papers over the course of his career. He was elected to the U.S. National Academy of Sciences at the age of 45. Korsmeyer died of lung cancer in 2005, at the age of 54.

(See a Problem?)

Stanley J. Korsmeyer's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death (1993) (6237)
Cell Death Critical Control Points (2004) (4753)
Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death (2001) (4030)
Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death (1990) (3857)
BCL-2 family members and the mitochondria in apoptosis. (1999) (3743)
Bcl-2 functions in an antioxidant pathway to prevent apoptosis (1993) (3511)
An inhibitor of Bcl-2 family proteins induces regression of solid tumours (2005) (3269)
Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL (1996) (2770)
Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death (1995) (2193)
BCL-2 family: regulators of cell death. (1998) (1780)
BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. (2001) (1707)
Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair (1993) (1699)
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. (2002) (1646)
Cell Death in Development (1999) (1553)
Bax-Deficient Mice with Lymphoid Hyperplasia and Male Germ Cell Death (1995) (1547)
MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia (2002) (1509)
Molecular thanatopsis: a discourse on the BCL2 family and cell death. (1996) (1448)
The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. (2000) (1438)
BAX and BAK Regulation of Endoplasmic Reticulum Ca2+: A Control Point for Apoptosis (2003) (1427)
BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax (1994) (1354)
bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes (1991) (1278)
tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. (2000) (1277)
bcl-2-Immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation (1989) (1267)
BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death. (1991) (1255)
Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around Jh on chromosome 14 and near a transcriptional unit on 18 (1985) (1233)
Bcl-2 initiates a new category of oncogenes: regulators of cell death. (1992) (1206)
Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members. (2006) (1204)
Activation of Apoptosis in Vivo by a Hydrocarbon-Stapled BH3 Helix (2004) (1179)
Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis (1998) (1157)
BCL-2 Is Phosphorylated and Inactivated by an ASK1/Jun N-Terminal Protein Kinase Pathway Normally Activated at G2/M (1999) (1089)
Caspase Cleaved BID Targets Mitochondria and Is Required for Cytochrome c Release, while BCL-XL Prevents This Release but Not Tumor Necrosis Factor-R1/Fas Death* (1999) (1089)
Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis (1999) (1041)
Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c (2000) (1021)
BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases. (1996) (985)
BID: a novel BH3 domain-only death agonist. (1996) (983)
A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis. (2002) (981)
Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis (2012) (980)
Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines. (1990) (941)
Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18) (1991) (915)
Structure of the human immunoglobulin μ locus: Characterization of embryonic and rearranged J and D genes (1981) (914)
Altered Hox expression and segmental identity in Mll-mutant mice (1995) (910)
Multiple Bcl-2 family members demonstrate selective dimerizations with Bax. (1995) (892)
Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell death. (1993) (878)
Checkpoints of dueling dimers foil death wishes (1994) (869)
Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1 (2003) (827)
Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia. (2005) (811)
VDAC2 Inhibits BAK Activation and Mitochondrial Apoptosis (2003) (780)
BAX Is Required for Neuronal Death after Trophic Factor Deprivation and during Development (1996) (773)
Bcl2 Regulation by the Melanocyte Master Regulator Mitf Modulates Lineage Survival and Melanoma Cell Viability (2002) (735)
Regulators of cell death. (1995) (731)
BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis (2003) (713)
Mechanisms of cytochrome c release by proapoptotic BCL-2 family members. (2003) (706)
The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins. (1992) (675)
Bax suppresses tumorigenesis and stimulates apoptosis in vivo (1997) (675)
Regulated Targeting of BAX to Mitochondria (1998) (661)
Differential Modulation of Apoptosis Sensitivity in CD95 Type I and Type II Cells* (1999) (658)
Detection of the apoptosis-suppressing oncoprotein bc1-2 in hormone-refractory human prostate cancers. (1993) (656)
Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A. (1999) (650)
BCL-2 gene family and the regulation of programmed cell death. (1995) (619)
Immunoglobulin-gene rearrangements as unique clonal markers in human lymphoid neoplasms. (1983) (614)
Bcl-2 gene family in the nervous system. (1997) (602)
Immunoglobulin gene rearrangement and cell surface antigen expression in acute lymphocytic leukemias of T cell and B cell precursor origins. (1983) (596)
Obligate Role of Anti-Apoptotic MCL-1 in the Survival of Hematopoietic Stem Cells (2005) (588)
Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis. (2000) (571)
Developmental hierarchy of immunoglobulin gene rearrangements in human leukemic pre-B-cells. (1981) (567)
p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD (2001) (543)
Apoptosis in the development and maintenance of the immune system (2003) (522)
Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2. (1997) (522)
Alternative promoters and exons, somatic mutation and deregulation of the Bcl‐2‐Ig fusion gene in lymphoma. (1988) (520)
BAX-dependent transport of cytochrome c reconstituted in pure liposomes (2000) (483)
Proapoptotic BAX and BAK Modulate the Unfolded Protein Response by a Direct Interaction with IRE1α (2006) (473)
Prevention of lymphocyte cell death in sepsis improves survival in mice. (1999) (468)
Bcl-XL and Bcl-2 repress a common pathway of cell death (1995) (462)
Expression of interleukin 2 receptors on activated human B cells (1984) (458)
Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum. (2005) (454)
BID regulation by p53 contributes to chemosensitivity (2002) (450)
bcl-2 protein expression is widespread in the developing nervous system and retained in the adult PNS. (1994) (442)
Widespread Elimination of Naturally Occurring Neuronal Death inBax-Deficient Mice (1998) (441)
Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification. (2003) (417)
Bcl-2 and Bax function independently to regulate cell death (1997) (414)
Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis. (1999) (407)
Solution Structure of the Proapoptotic Molecule BID A Structural Basis for Apoptotic Agonists and Antagonists (1999) (403)
Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia. (1991) (401)
bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis. (1997) (401)
Bax Deletion Further Orders the Cell Death Pathway in Cerebellar Granule Cells and Suggests a Caspase-independent Pathway to Cell Death (1997) (399)
Targeting of Bcl-2 to the mitochondrial outer membrane by a COOH-terminal signal anchor sequence. (1993) (395)
Mcl-1 deficiency results in peri-implantation embryonic lethality. (2000) (393)
Rearrangement and expression of immunoglobulin genes and expression of Tac antigen in hairy cell leukemia. (1983) (393)
A stapled BID BH3 helix directly binds and activates BAX. (2006) (388)
Involvement of Microtubules in the Regulation of Bcl2 Phosphorylation and Apoptosis through Cyclic AMP-Dependent Protein Kinase (1998) (376)
Rearrangements of genes for the antigen receptor on T cells as markers of lineage and clonality in human lymphoid neoplasms. (1985) (376)
Cross talk between cell death and cell cycle progression: BCL-2 regulates NFAT-mediated activation. (1996) (358)
Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease (2001) (358)
Reactivation of the p53 Tumor Suppressor Pathway by a Stapled p53 Peptide (2007) (351)
Thermostable DNA polymerase chain amplification of t(14;18) chromosome breakpoints and detection of minimal residual disease. (1988) (350)
Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation. (2003) (350)
Prolongation of ovarian lifespan into advanced chronological age by Bax-deficiency (1999) (350)
Fas-induced Activation of the Cell Death-related Protease CPP32 Is Inhibited by Bcl-2 and by ICE Family Protease Inhibitors* (1996) (344)
Human acute leukemia cell line with the t(4;11) chromosomal rearrangement exhibits B lineage and monocytic characteristics. (1985) (344)
Bax Involvement in p53-Mediated Neuronal Cell Death (1998) (340)
Molecular rearrangements on chromosome 11q23 predominate in infant acute lymphoblastic leukemia and are associated with specific biologic variables and poor outcome. (1993) (335)
Developmental regulation of the Bcl‐2 protein and susceptibility to cell death in B lymphocytes. (1994) (326)
MLL, a mammalian trithorax-group gene, functions as a transcriptional maintenance factor in morphogenesis. (1998) (324)
BH3 Domain of BAD Is Required for Heterodimerization with BCL-XL and Pro-apoptotic Activity* (1997) (322)
B cell origin of non-T cell acute lymphoblastic leukemia. A model for discrete stages of neoplastic and normal pre-B cell differentiation. (1984) (312)
Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity. (2004) (312)
Clustered arrangement of immunoglobulin λ constant region genes in man (1981) (305)
Bcl-2 gene family and the regulation of programmed cell death. (1994) (304)
Hematopoietic malignancies demonstrate loss-of-function mutations of BAX. (1998) (304)
Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes. (1993) (303)
Constitutive expression of human Bcl-2 modulates nitrogen mustard and camptothecin induced apoptosis. (1993) (300)
Dual role of proapoptotic BAD in insulin secretion and beta cell survival (2008) (297)
Human immunoglobulin κ light-chain genes are deleted or rearranged in λ-producing B cells (1981) (294)
A spatially and temporally restricted mouse model of soft tissue sarcoma (2007) (292)
Expression of Bcl-2 and Bcl-2-Ig fusion transcripts in normal and neoplastic cells. (1987) (291)
Phosphorylation of BCL‐2 regulates ER Ca2+ homeostasis and apoptosis (2004) (288)
Hyperglycemia induces apoptosis in pre-implantation embryos through cell death effector pathways (1998) (284)
Chromosomal translocations in lymphoid malignancies reveal novel proto-oncogenes. (1992) (284)
Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points. (1994) (281)
Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis. (2002) (278)
A novel, high conductance channel of mitochondria linked to apoptosis in mammalian cells and Bax expression in yeast (2001) (276)
Mouse models of cell death (2001) (276)
Bad-deficient mice develop diffuse large B cell lymphoma (2003) (275)
Isolation of single-copy human genes from a library of yeast artificial chromosome clones. (1989) (273)
Reactive oxygen species and the regulation of cell death by the Bcl-2 gene family. (1995) (273)
cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes (2003) (272)
Defects in yolk sac hematopoiesis in Mll-null embryos. (1997) (272)
Taspase1 A Threonine Aspartase Required for Cleavage of MLL and Proper HOX Gene Expression (2003) (270)
Definitive hematopoiesis requires the mixed-lineage leukemia gene. (2004) (267)
Hox11 controls the genesis of the spleen (1994) (267)
Mammalian Trithorax and polycomb-group homologues are antagonistic regulators of homeotic development. (1999) (264)
BID mediates neuronal cell death after oxygen/ glucose deprivation and focal cerebral ischemia (2001) (257)
FLT3 mutations in childhood acute lymphoblastic leukemia. (2004) (256)
MLL and CREB Bind Cooperatively to the Nuclear Coactivator CREB-Binding Protein (2001) (255)
Proteolytic Cleavage of MLL Generates a Complex of N- and C-Terminal Fragments That Confers Protein Stability and Subnuclear Localization (2003) (253)
A Role for Proapoptotic BID in the DNA-Damage Response (2005) (249)
Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product. (1993) (244)
Deregulated Bcl-2-immunoglobulin transgene expands a resting but responsive immunoglobulin M and D-expressing B-cell population (1990) (239)
Oligomeric Bax is a component of the putative cytochrome c release channel MAC, mitochondrial apoptosis-induced channel. (2005) (239)
Mechanism of the t(14;18) chromosomal translocation: structural analysis of both derivative 14 and 18 reciprocal partners. (1987) (235)
The t(11;14)(p15;q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein (1989) (232)
Bcl-2 maintains B cell memory (1991) (221)
Bax-Dependent Spermatogonia Apoptosis Is Required for Testicular Development and Spermatogenesis1 (2002) (219)
Bcl-2: a repressor of lymphocyte death. (1992) (219)
Mutagenesis of the BH3 Domain of BAX Identifies Residues Critical for Dimerization and Killing (1998) (219)
BAX enhances paclitaxel-induced apoptosis through a p53-independent pathway. (1996) (216)
Activation of BAD by Therapeutic Inhibition of Epidermal Growth Factor Receptor and Transactivation by Insulin-like Growth Factor Receptor* (2002) (215)
p53 Controls Radiation-Induced Gastrointestinal Syndrome in Mice Independent of Apoptosis (2009) (213)
Involvement of proapoptotic molecules Bax and Bak in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced mitochondrial disruption and apoptosis: differential regulation of cytochrome c and Smac/DIABLO release. (2003) (209)
On the Key Role of Secondary Lymphoid Organs in Antiviral Immune Responses Studied in Alymphoplastic (aly/aly) and Spleenless (Hox11− /−) Mutant Mice (1997) (209)
Lymphoid blast crises of chronic myelogenous leukemia represent stages in the development of B-cell precursors. (1983) (208)
A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth. (2002) (208)
HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint (1997) (206)
Role of BCL-2 in the survival and function of developing and mature sympathetic neurons (1995) (201)
Immunolocalization of the Bcl-2 protein within hematopoietic neoplasms. (1991) (200)
A uniform deleting element mediates the loss of κ genes in human B cells (1985) (198)
A negative regulatory element in the bcl-2 5'-untranslated region inhibits expression from an upstream promoter (1993) (198)
Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease. (2005) (197)
An Mll-Dependent Hox Program Drives Hematopoietic Progenitor Expansion (2004) (197)
Multiple signaling pathways promote B lymphocyte stimulator dependent B-cell growth and survival. (2008) (196)
Differential mRNA expression of Ara-C-metabolizing enzymes explains Ara-C sensitivity in MLL gene-rearranged infant acute lymphoblastic leukemia. (2003) (194)
Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions. (2004) (187)
Human immunoglobulin D segments encoded in tandem multigenic families (1981) (187)
Bax Loss Impairs Myc-Induced Apoptosis and Circumvents the Selection of p53 Mutations during Myc-Mediated Lymphomagenesis (2001) (184)
Proapoptotic BID is required for myeloid homeostasis and tumor suppression. (2003) (182)
Antiapoptotic BCL-2 is required for maintenance of a model leukemia. (2004) (177)
Neurotrophins Support the Development of Diverse Sensory Axon Morphologies (1999) (173)
Role of membrane anchor domain of Bcl-2 in suppression of apoptosis caused by E1B-defective adenovirus. (1994) (172)
Deletion of the human T-cell receptor δ-gene by a site-specific recombination (1988) (171)
The apoptotic v-cyclin–CDK6 complex phosphorylates and inactivates Bcl-2 (2000) (168)
Bcl-2 protein expression during murine development. (1994) (168)
Molecular rearrangements of the MLL gene are present in most cases of infant acute myeloid leukemia and are strongly correlated with monocytic or myelomonocytic phenotypes. (1994) (164)
The role of MLL in hematopoiesis and leukemia (2002) (160)
c-Myc Functionally Cooperates with Bax To Induce Apoptosis (2002) (157)
Ligand activation of the aromatic hydrocarbon receptor transcription factor drives Bax-dependent apoptosis in developing fetal ovarian germ cells. (2002) (152)
Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system. (2000) (151)
Enforced Bcl-2 Expression Inhibits Antigen-mediated Clonal Elimination of Peripheral B Cells in an Antigen Dose–dependent Manner and Promotes Receptor Editing in Autoreactive, Immature B Cells (1997) (149)
Fulminant metanephric apoptosis and abnormal kidney development in bcl-2-deficient mice. (1995) (148)
A reversible component of mitochondrial respiratory dysfunction in apoptosis can be rescued by exogenous cytochrome c (2001) (148)
Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide. (2007) (147)
Rnx deficiency results in congenital central hypoventilation (2000) (144)
Growth- and tumor-promoting effects of deregulated BCL2 in human B-lymphoblastoid cells. (1989) (141)
The BCL2A1 gene as a pre–T cell receptor–induced regulator of thymocyte survival (2005) (141)
Enhanced Oxidative Stress and Altered Antioxidants in Brains of Bcl‐2‐Deficient Mice (1998) (140)
Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression. (2006) (138)
BAX Contributes to Apoptotic-Like Death Following Neonatal Hypoxia-Ischemia: Evidence for Distinct Apoptosis Pathways (2001) (131)
Biochemical and Genetic Analysis of the Mitochondrial Response of Yeast to BAX and BCL-XL (2000) (128)
Haploid loss of bax leads to accelerated mammary tumor development in C3(1)/SV40‐TAg transgenic mice: reduction in protective apoptotic response at the preneoplastic stage (1999) (127)
Normal human B cells display ordered light chain gene rearrangements and deletions (1982) (127)
Regulation of endoplasmic reticulum Ca2+ dynamics by proapoptotic BCL-2 family members. (2003) (127)
Enx (Hox11L1)-deficient mice develop myenteric neuronal hyperplasia and megacolon (1997) (125)
Evidence for involvement of Bax and p53, but not caspases, in radiation‐induced cell death of cultured postnatal hippocampal neurons (1998) (120)
Variable amplification of immunoglobulin λ light-chain genes in human populations (1983) (119)
Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK (2001) (117)
Proapoptotic BAX and BAK control multiple initiator caspases (2005) (116)
Conditional MLL‐CBP targets GMP and models therapy‐related myeloproliferative disease (2005) (114)
Suppression of developmental retinal cell death but not of photoreceptor degeneration in Bax-deficient mice. (1998) (114)
Gene rearrangements as markers of clonal variation and minimal residual disease in acute lymphoblastic leukemia. (1987) (111)
BID-dependent and BID-independent pathways for BAX insertion into mitochondria (2000) (111)
Damage-induced apoptosis in intestinal epithelia from bcl-2-null and bax-null mice: investigations of the mechanistic determinants of epithelial apoptosis in vivo (1999) (111)
Cell death induced by granzyme C. (2003) (111)
Expression of the bcl-2 protooncogene in the cycling adult mouse hair follicle. (1994) (109)
Thymic overexpression of Ttg-1 in transgenic mice results in T-cell acute lymphoblastic leukemia/lymphoma (1992) (109)
Inhibition of virus-induced neuronal apoptosis by Bax (1999) (106)
Enhanced Oligodendrocyte Survival after Spinal Cord Injury in Bax-Deficient Mice and Mice with Delayed Wallerian Degeneration (2003) (106)
Chloroquine‐Induced Neuronal Cell Death Is p53 and Bcl‐2 Family‐Dependent But Caspase‐Independent (2001) (101)
PP2A Regulates BCL-2 Phosphorylation and Proteasome-mediated Degradation at the Endoplasmic Reticulum* (2006) (97)
Induction of differentiation in a case of common acute lymphoblastic leukemia. (1982) (94)
Human J chain gene. Structure and expression in B lymphoid cells (1985) (93)
Human bcl-2 Gene Attenuates the Ability of Rabbit Lens Epithelial Cells against H2O2-induced Apoptosis through Down-regulation of the αB-crystallin Gene* (2001) (92)
A Membrane-targeted BID BCL-2 Homology 3 Peptide Is Sufficient for High Potency Activation of BAX in Vitro* (2006) (91)
Bax accelerates tumorigenesis in p53-deficient mice. (2001) (90)
Placement of the BCL2 Family Member BAX in the Death Pathway of Sympathetic Neurons Activated by Trophic Factor Deprivation (1998) (89)
Peripheral T-cell lymphoma in lckpr-bcl-2 transgenic mice. (1995) (89)
Neurodegeneration in Lurcher Mice Occurs via Multiple Cell Death Pathways (2000) (87)
Refinement of lymphoma cytogenetics by the chromosome 18q21 major breakpoint region. (1987) (87)
Zinc-induced neuronal death in cortical neurons. (2000) (84)
Traumatic Brain Injury in Mice Deficient in Bid: Effects on Histopathology and Functional Outcome (2006) (83)
Bcl-2: an antidote to programmed cell death. (1992) (83)
Switching mechanisms of cell death in mdm2- and mdm4-null mice by deletion of p53 downstream targets. (2003) (83)
Latent membrane protein of Epstein-Barr virus induces cellular phenotypes independently of expression of Bcl-2 (1993) (81)
Bax channel inhibitors prevent mitochondrion-mediated apoptosis and protect neurons in a model of global brain ischemia. (2012) (80)
Hyperglycemia induces apoptosis in pre-implantation embryos through cell death effector pathways (2002) (79)
MLL-rearranged leukemias: insights from gene expression profiling. (2003) (79)
The T cell receptor repertoire of CD4-8+ thymocytes is altered by overexpression of the BCL-2 protooncogene in the thymus (1994) (79)
Use of yeast artificial chromosome clones for mapping and walking within human chromosome segment 18q21.3. (1989) (78)
Yeast artificial chromosome cloning of a two-megabase-size contig within chromosomal band 18q21 establishes physical linkage between BCL2 and plasminogen activator inhibitor type-2. (1991) (78)
Lymphocytotoxic antibody in inflammatory bowel disease. A family study. (1975) (78)
Conformational Changes in BID, a Pro-apoptotic BCL-2 Family Member, upon Membrane Binding (2005) (77)
Uncleaved TFIIA Is a Substrate for Taspase 1 and Active in Transcription (2006) (76)
Disorders of B cells and helper T cells in the pathogenesis of the immunoglobulin deficiency of patients with ataxia telangiectasia. (1983) (76)
Effects of cytochrome c on the mitochondrial apoptosis-induced channel MAC. (2004) (76)
Jak3 Selectively Regulates Bax and Bcl-2 Expression To Promote T-Cell Development (2001) (75)
Clustered arrangement of immunoglobulin lambda constant region genes in man. (1981) (74)
Developmental Regulation of Eed Complex Composition Governs a Switch in Global Histone Modification in Brain* (2007) (74)
The proapoptotic BCL-2 family member BIM mediates motoneuron loss in a model of amyotrophic lateral sclerosis (2007) (73)
Regulation of B cell survival in xid mice by the proto-oncogene bcl-2. (1996) (71)
Human T-cell antigen receptor (TCR) delta-chain locus and elements responsible for its deletion are within the TCR alpha-chain locus. (1988) (71)
NIH conference. Molecular genetic analysis of human lymphoid neoplasms. Immunoglobulin genes and the c-myc oncogene. (1985) (70)
Interleukin 7-dependent B lymphocyte precursor cells are ultrasensitive to apoptosis (1994) (69)
Bax, caspase-2, and caspase-3 are required for ovarian follicle loss caused by 4-vinylcyclohexene diepoxide exposure of female mice in vivo. (2003) (69)
BCL-XL-regulated apoptosis in T cell development. (1997) (69)
Gain of Bcl-2 is more potent than bax loss in regulating mammary epithelial cell survival in vivo. (1999) (69)
Immunoglobulin and T cell receptor gene configuration in acute lymphoblastic leukemia of infancy. (1987) (69)
A uniform deleting element mediates the loss of kappa genes in human B cells. (1985) (67)
Death and survival signals determine active/inactive conformations of pro-apoptotic BAX, BAD, and BID molecules. (1999) (66)
B cell, helper T cell, and suppressor T cell abnormalities contribute to disordered immunoglobulin synthesis in patients following bone marrow transplantation. (1982) (64)
Peripheral blood T and B cells in chronic inflammatory bowel disease. (1974) (64)
p600, a unique protein required for membrane morphogenesis and cell survival. (2005) (62)
Coming to terms with death: apoptosis in cancer and immune development. (1994) (61)
Development expression of Hox11 and specification of splenic cell fate. (1995) (61)
T cell receptor alpha-, beta-, and gamma-genes in T cell and pre-B cell acute lymphoblastic leukemia. (1987) (61)
Antigen receptor genes as molecular markers of lymphoid neoplasms. (1987) (60)
Deletional rearrangement in the human T-cell receptor alpha-chain locus. (1987) (60)
Heterodimerization with Bax is required for Bcl-2 to repress cell death. (1995) (60)
Adenovirus E1B 19-kDa Death Suppressor Protein Interacts with Bax but Not with Bad* (1996) (60)
Bax Channel Inhibitors Prevent Mitochondrion-mediated Apoptosis and Protect Neurons in a Model of Global Brain Ischemia* (2005) (59)
Differentiation and cell death: lessons from the immune system. (1994) (58)
Immunoglobulin lambda light-chain-related genes 14.1 and 16.1 are expressed in pre-B cells and may encode the human immunoglobulin omega light-chain protein. (1989) (57)
Human immunoglobulin kappa light-chain genes are deleted or rearranged in lambda-producing B cells. (1981) (57)
Bcl-2: B cell life, death and neoplasia. (1990) (55)
Serum lymphocytotoxic and lymphocytophilic antibody activity in inflammatory bowel disease. (1974) (55)
The activity of the murine Bax promoter is regulated by Sp1/3 and E-box binding proteins but not by p53 (1999) (54)
BH3 peptidomimetics potently activate apoptosis and demonstrate single agent efficacy in neuroblastoma (2006) (54)
Clonal evolution of t(14;18) follicular lymphomas demonstrated by immunoglobulin genes and the 18q21 major breakpoint region. (1987) (54)
Errors of homeostasis and deregulated apoptosis. (1997) (53)
The t(10;14)(q24;q11) of T-cell acute lymphoblastic leukemia juxtaposes the delta T-cell receptor with TCL3, a conserved and activated locus at 10q24. (1990) (53)
Role of Proapoptotic BAX in Propagation of Chlamydia muridarum (the Mouse Pneumonitis Strain of Chlamydia trachomatis) and the Host Inflammatory Response* (2003) (53)
Collaboration of pim-1 and bcl-2 in lymphomagenesis. (1992) (51)
Translocations that highlight chromosomal regions of differentiated activity. (1985) (50)
The kappa-deleting element. Germline and rearranged, duplicated and dispersed forms (1988) (50)
BAD Is a Pro-survival Factor Prior to Activation of Its Pro-apoptotic Function* (2004) (49)
Absence of Ig V region gene somatic hypermutation in advanced Burkitt's lymphoma. (1989) (49)
A major human immunodeficiency virus type 1-initiated killing pathway distinct from apoptosis (1997) (49)
The VDAC2-BAK Rheostat Controls Thymocyte Survival (2009) (49)
Biochemical and Genetic Analysis of the Mitochondrial Response of Yeast to BAX and BCL-X L (2000) (48)
Expression of apoptosis inhibitor protein Mcl1 linked to neuroprotection in CNS neurons (2004) (47)
A DNA insertion/deletion necessitates an aberrant RNA splice accounting for a mu heavy chain disease protein. (1986) (45)
Tuberin activates the proapoptotic molecule BAD (2006) (45)
Proteolysis of MLL Family Proteins Is Essential for Taspase1−Orchestrated Cell Cycle Progression. (2006) (44)
Cellular origin of hairy cell leukemia: malignant B cells that express receptors for T cell growth factor. (1984) (43)
Loss of Bax alters tumor spectrum and tumor numbers in ARF-deficient mice. (2002) (40)
Trophic support promotes survival of bcl-x-deficient telencephalic cells in vitro (1998) (40)
Evolutionary comparison of murine and human delta T-cell receptor deleting elements. (1989) (39)
Breakpoints at 11q23 in infant leukemias with the t(11;19)(q23;p13) are clustered. (1992) (39)
Proapoptotic histone H1.2 induces CASP‐3 and ‐7 activation by forming a protein complex with CYT c, APAF‐1 and CASP‐9 (2007) (39)
BAD partly reverses paclitaxel resistance in human ovarian cancer cells (1998) (38)
A pharmacologic inhibitor of the protease Taspase1 effectively inhibits breast and brain tumor growth. (2012) (38)
Function of BID – a Molecule of the bcl-2 Family – in Ischemic Cell Death in the Brain (2002) (37)
Meiotic recombination between yeast artificial chromosomes yields a single clone containing the entire BCL2 protooncogene. (1990) (37)
A BAX/BAK and Cyclophilin D-Independent Intrinsic Apoptosis Pathway (2012) (35)
Immunoglobulin gene rearrangements and expression in diffuse histiocytic lymphomas reveal cellular lineage, molecular defects, and sites of chromosomal translocation. (1986) (35)
In vitro enhancement of immunoglobulin gene expression in chronic lymphocytic leukemia. (1984) (33)
Caspase regulation of genotoxin‐induced neural precursor cell death (2003) (32)
Multiple genomic defects result in an alternative RNA splice creating a human gamma H chain disease protein. (1988) (32)
T-cell translocation gene 1 (Ttg-1) encodes a nuclear protein normally expressed in neural lineage cells. (1991) (32)
Deletion of the human T-cell receptor delta-gene by a site-specific recombination. (1988) (31)
Bid regulation of neuronal apoptosis. (2001) (31)
BCLW mediates survival of postmitotic Sertoli cells by regulating BAX activity. (2001) (31)
Gene mutations and alternate RNA splicing result in truncated Ig L chains in human gamma H chain disease. (1988) (31)
The chromosome 4q21 gene (AF-4/FEL) is widely expressed in normal tissues and shows breakpoint diversity in t(4;11)(q21;q23) acute leukemia (1993) (30)
Survival and death of prelymphomatous B-cells from N-myc/bcl-2 double transgenic mice correlates with the regulation of intracellular Ca2+ fluxes. (1995) (30)
FLT 3 mutations in childhood acute lymphoblastic leukemia (2004) (30)
Induction of plasmacytoid differentiation by phorbol ester in B-cell lymphoma cell lines bearing 8;14 translocations. (1984) (30)
A role for Bax in the regulation of apoptosis in mouse mast cells. (2000) (29)
Human T-cell antigen receptor (TCR) 6-chain locus and elements responsible for its deletion are within the TCR a-chain locus (28)
Immunoglobulin A light-chain-related genes 14 . 1 and 16 . 1 are expressed in pre-B cells and may encode the human immunoglobulin t light-chain protein (28)
The chromosome 4q21 gene (AF-4/FEL) is widely expressed in normal tissues and shows breakpoint diversity in t(4;11)(q21;q23) acute leukemia. (1993) (28)
Platelet-derived growth factor (PDGF) B and A homodimers transform murine fibroblasts depending on the genetic background of the cell. (1994) (27)
Differences in Bcl‐2‐ and Bax‐independent function in regulating apoptosis in sensory neuron populations (2000) (24)
Radiation-induced apoptosis is not enhanced by expression of either p53 or BAX in SW626 ovarian cancer cells (1997) (24)
LYMPHOCYTOTOXIC AND RNA ANTIBODIES IN INFLAMMATORY BOWEL DISEASE: A COMPARATIVE STUDY IN PATIENTS AND THEIR FAMILIES (1976) (22)
Untangling the web: mitochondrial fission and apoptosis. (2004) (22)
The ability of Bcl-x(L) and Bcl-2 to prevent apoptosis can be differentially regulated. (1996) (21)
Studies of human lymphocyte interactions with emphasis on soluble suppressor activity. (1978) (20)
Variable amplification of immunoglobulin lambda light-chain genes in human populations. (1983) (20)
Epstein-Barr virus immortalization of normal cells of B cell lineage with nonproductive, rearranged immunoglobulin genes. (1986) (19)
Bax regulates c-Myc-induced mammary tumour apoptosis but not proliferation in MMTV-c-myc transgenic mice (2004) (18)
Apoptotic death of lymphocytes in murine acquired immunodeficiency syndrome: Involvement of Fas‐Fas ligand interaction (1995) (18)
BID, a proapoptotic BCL-2 family member, is localized to mouse chromosome 6 and human chromosome 22q11. (1998) (17)
Life, death and nuclear spots (1998) (17)
Genetic transfer and expression of reconstructed yeast artificial chromosomes containing normal and translocated BCL2 proto-oncogenes (1993) (16)
Radiation-induced apoptosis is differentially regulated in primary B cells from normal mice and mice with the CBA/N X-linked immunodeficiency. (1995) (16)
BAX enhances paclitaxel-induced apoptosis through a p 53-independent pathway ( drug resistance y chemotherapy y ovarian y cancer ) (1996) (13)
Combination chemotherapy for locally advanced pancreatic cancer: equivalence to external beam irradiation and implication for future management. (1983) (12)
The Ig heavy chain 3' end confers a posttranscriptional processing advantage to Bcl-2-IgH fusion RNA in t(14;18) lymphoma. (1998) (12)
Programmed cell death: Bcl-2. (1993) (12)
Analysis of hypermutation in immunoglobulin heavy chain passenger transgenes (1996) (11)
Genomic approaches to the pathogenesis and treatment of acute lymphoblastic leukemias (2002) (11)
Programmed cell death and the regulation of homeostasis. (1999) (10)
Differential specificity of lymphocytotoxins from patients with systemic lupus erythematosus and inflammatory bowel disease. (1976) (9)
Immunoglobulin genes: Rearrangement and translocation in human lymphoid malignancy (2004) (8)
Skewed B cell VH family repertoire in Bcl-2-Ig transgenic mice. (1991) (8)
A pre-translational defect in a case of human mu heavy chain disease. (1986) (8)
p 600 , a unique protein required for membrane morphogenesis and cell survival (2005) (8)
Cancer Turning in on death programs (1998) (8)
Immunoglobulin and T-cell receptor genes reveal the clonality, lineage, and translocations of lymphoid neoplasms. (1987) (8)
Germline and Rearranged, Duplicated and Dispersed Forms (1988) (7)
Phase I trial and clinical pharmacology of 1-(2-chloroethyl)-3-(2,6-dioxo-3-piperidyl)-1-nitrosourea. (1981) (5)
Interleukin-2 receptors on activated malignant and normal B-cells. (1984) (5)
Regulation of the humoral immune response: from immunoglobulin genes to regulatory T cell networks. (1983) (4)
13 – Immunoglobulin Genes in Human Lymphoid Neoplasms (1989) (4)
Genetic Rearrangements of Human Immunoglobulin Genes (1984) (4)
Corrigendum: Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis (2013) (4)
B-lymphoid neoplasms: immunoglobulin genes as molecular determinants of clonality, lineage, differentiation, and translocation. (1988) (3)
Neurotrophins Support the Development of Diverse Sensory (1999) (3)
Human B-cell precursor leukemias. (1984) (3)
Developmental hierarchy ofimmunoglobulin generearrangements inhumanleukemic pre-B-cells (1981) (2)
Irisin and the therapeutic benefits of exercise (2012) (2)
A MEMBRANE-TARGETED BID BH3 PEPTIDE IS SUFFICIENT FOR HIGH POTENCY ACTIVATION OF BAX IN VITRO (2006) (2)
The arrangement of immunoglobulin, T cell antigen receptor, and interleukin 2 receptor genes in human lymphoid neoplasms. (1986) (2)
CPD Damage Recognition by Transcribing RNA Polymerase II (2007) (2)
Using Mouse Genetics to Dissect the Cellular Target of Radiation in the GI Syndrome (2005) (2)
Survival Factor Stimulates ERK-Dependent Phosphorylation of BIM Inhibiting Its Association with BAX and Pro-Apoptotic Activity. (2004) (1)
Transgenic mice that redirect Ttg‐1 or Hox11 to the thymus develop T‐cell acute lymphoblastic leukemia/lymphoma (1992) (1)
Solution Structure of the Anti-apoptotic Protein Bcl-xL in Complex with ""SAR by NMR"" Ligands (2005) (1)
2685: Utilizing Mouse Genetics to Dissect the Cellular Target and Molecular Mechanism of Acute and Late Toxicity of Abdominal Radiation Therapy (2006) (1)
HumanT-cell antigen receptor (TCR)6-chain locus andelements responsible foritsdeletion arewithin theTCRa-chain locus (1988) (1)
Selective Targeting of the p53-hDM2 Interaction Using Hydrocarbon-Stapled p53 Peptides. (2006) (1)
Molecular Regulation of Testicular Cell Death (1998) (1)
Breakpoints at l l q 2 3 in Infant Leukemias With the t(11;19)(q23;p13) Are Clustered (2003) (1)
Absence of reproductive senescence in bax-deficient female mice (1998) (1)
Anti-Leukemic Potency of Stapled BH3 Helices Correlates with Their Capacity for Bifunctional Activation of Apoptotic Pathways. (2006) (1)
Dysfunction and Death Proapoptotic BAX and BAK : A Requisite Gateway to Mitochondrial (2014) (1)
Comparison of Human Genomics and Genetic Models of Cancer to Identify Novel Therapeutic Targets (2003) (1)
464 Regulation of apoptosis by synthetic helices of the BCL-2 family (2004) (1)
Induction of Differentiation in B Cell Leukemia (1984) (1)
Expression During Murine Development (2007) (1)
DNA Rearrangements as Unique Molecular Markers of Clonality, Cellular Lineage, Differentiation, and Translocation (1985) (1)
Molecular genetics of human lymphoid neoplasms (1987) (1)
Molecular Markers of Clonality, Lineage, Differentiation, and Translocation in B Cell Neoplasms (1986) (0)
The t(10;14)(q24;qll) of T-cell acute lymphoblastic leukemia juxtaposes the 6 T-cell receptor with TCL3, a conserved and activated locus at 10q24 (chromosomal (0)
Stabilized alpha-helix peptides and uses thereof (2004) (0)
Human delta T cell receptor: rearrangement, deletion, and translocation. (1988) (0)
Translocations de mll indiquant un profil d'expression genique distinct qui permet de distinguer une leucemie unique (2002) (0)
Therapeutics , Targets , and Chemical Biology A Pharmacologic Inhibitor of the Protease Taspase 1 Effectively Inhibits Breast and Brain Tumor Growth (2012) (0)
Rapid Publications In Vitro Enhancement of Immunoglobulin Gene Expression in Chronic Lymphocytic Leukemia (2013) (0)
Interleukln 7-dependent B Lymphocyte Precursor Cells Are Ultrasensitive to Apoptmis (2003) (0)
Mcl-1, which can prevent leukemia cell death, is necessary for bone marrow stem cell survival (2005) (0)
Enhanced susceptibility of motor neurons to excitotoxicity is dependent on Ca2+-permeable AMPA/kainate receptors and BAX expression (1997) (0)
leukemia rearranged infant acute lymphoblastic - Ara-C sensitivity in MLL gene metabolizing enzymes explains - Differential mRNA expression of Ara-C (2013) (0)
Release Differential Regulation of Cytochrome c and Smac / DIABLO ( TRAIL )-induced Mitochondrial Disruption and Apoptosis : Tumor Necrosis Factor-related Apoptosis-inducing Ligand Involvement of Proapoptotic Molecules Bax and Bak in Updated (2003) (0)
Mustard and Camptothecin Induced Apoptosis Modulates Nitrogen Bcl-2 Constitutive Expression of Human Updated (2006) (0)
Latent MembraneProtein ofEpstein-Barr VirusInduces Cellular Phenotypes Independently ofExpression ofBcl-2 (1993) (0)
Subject Index, Vol. 3, 1984 (1984) (0)
lymphoblastic leukemia of infancy Immunoglobulin and T cell receptor gene configuration in acute (2011) (0)
Contents, Vol. 3, 1984 (1984) (0)
Yeast artificial chromosome yac cloning of the t 4 11 acute lymphoblastic leukemia breakpoint (1992) (0)
Subcellular Localization of an Oncoprotein using Immunofluorescence, Confocal Imaging and Immuno Electron Microscopy (1998) (0)
The maturation of a pre-B cell to an immunoglobulin (Ig)-bearing B cell requires an effective recombination of a light chain variable (VL) (2003) (0)
Abstracts of papers presented at the 1995 Meeting on Programmed Cell Death, September 20-September 24, 1995 (1995) (0)
Solution structure of domain 3 from human serum albumin complexed to an anti-apoptotic ligand directed against Bcl-xL and Bcl-2 (2005) (0)
DNA rearrangements as unique markers of clonal evolution, persistence, and recurrence in acute leukemia (1986) (0)
in Decreases Apoptosis and Improves Survival Overexpression of Bcl-2 in Transgenic Mice (1999) (0)
HUMAN IMMUNOGLOBULIN GENES: THE ONTOGENY OF SOMATIC REARRANGEMENTS (1981) (0)
An Mll-Dependent Hox Program Drives Hematopoietic Progenitor Expansion (2005) (0)
DNA Rearrangements as Unique Markers of Clonal Evolution, Recurrence and Translocation (1986) (0)
tBid induced change in crista topology (2012) (0)
Role of the Bcl-2 Proto-Oncogene in Neoplasia (1989) (0)
Abstracts of papers presented at the 1997 Meeting on Programmed Cell Death, September 17-September 21, 1997 (1997) (0)
"Brown and Beige Fat: Basic Biology and Potential New Therapeutics" (2013) (0)
Table of Contents (1988) (0)
STRUCTURE OF MOUSE BID, NMR, 20 STRUCTURES (1999) (0)
In memoriam: Stanley J. Korsmeyer (1950–2005) (2005) (0)
Alpha-helical peptides suitable for the activation or inhibition of cell death (2004) (0)
MOLECULAR GENETIC CLASSIFICATION OF ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) OF CHILDHOOD AND INFANCY: 11 (1989) (0)
Methode de traitement de l'apoptose et compositions associees (2002) (0)
ThymicOverexpression ofTtg-1 inTransgenic MiceResults inT-Cell AcuteLymnphoblastic Leukemia/Lymphoma (1992) (0)

This paper list is powered by the following services:

Other Resources About Stanley J. Korsmeyer

en.wikipedia.org

What Schools Are Affiliated With Stanley J. Korsmeyer?

Stanley J. Korsmeyer is affiliated with the following schools:

Stanley J. Korsmeyer's Academic­Influence.com Rankings