Stefan Karlsson
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Researcher ORCID 0000-0002-2353-2531
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(Suggest an Edit or Addition)Stefan Karlsson's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. (1993) (2028)
- Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knock out mice. (1995) (1080)
- Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling. (2003) (713)
- Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche (2011) (695)
- Abnormal angiogenesis but intact hematopoietic potential in TGF‐β type I receptor‐deficient mice (2001) (543)
- Transduction of nondividing cells using pseudotyped defective high-titer HIV type 1 particles. (1996) (401)
- Diagnosing and treating Diamond Blackfan anaemia: results of an international clinical consensus conference (2008) (395)
- Signaling pathways governing stem-cell fate. (2008) (368)
- Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to β-amyloid deposition in APP/PS1 double transgenic Alzheimer mice (2005) (301)
- Combination of interleukins 3 and 6 preserves stem cell function in culture and enhances retrovirus-mediated gene transfer into hematopoietic stem cells. (1989) (300)
- Transforming growth factor-beta 1 knockout mice. A mutation in one cytokine gene causes a dramatic inflammatory disease. (1993) (273)
- Overexpression of CXCR4 on human CD34+ progenitors increases their proliferation, migration, and NOD/SCID repopulation. (2004) (242)
- Immune dysregulation in TGF-beta 1-deficient mice. (1994) (237)
- Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable. (2002) (235)
- Chance or necessity? Insertional mutagenesis in gene therapy and its consequences. (2003) (234)
- Lentiviral vector transduction of NOD/SCID repopulating cells results in multiple vector integrations per transduced cell: risk of insertional mutagenesis. (2003) (222)
- Loss of expression of transforming growth factor beta in skin and skin tumors is associated with hyperproliferation and a high risk for malignant conversion. (1993) (220)
- Treatment of genetic defects in hematopoietic cell function by gene transfer. (1991) (220)
- Autoimmune manifestations in the transforming growth factor-beta 1 knockout mouse. (1996) (202)
- Human RPS19, the gene mutated in Diamond-Blackfan anemia, encodes a ribosomal protein required for the maturation of 40S ribosomal subunits. (2007) (201)
- The role of Smad signaling in hematopoiesis (2005) (201)
- Transforming growth factor-beta 1 null mice. An animal model for inflammatory disorders. (1995) (193)
- Transforming growth factor beta 1 (TGF-beta 1) controls expression of major histocompatibility genes in the postnatal mouse: aberrant histocompatibility antigen expression in the pathogenesis of the TGF-beta 1 null mouse phenotype. (1993) (175)
- TGF-β signaling in the control of hematopoietic stem cells. (2015) (173)
- Retroviral transfer of the glucocerebrosidase gene into CD34+ cells from patients with Gaucher disease: in vivo detection of transduced cells without myeloablation. (1998) (168)
- TGF-beta signaling-deficient hematopoietic stem cells have normal self-renewal and regenerative ability in vivo despite increased proliferative capacity in vitro. (2003) (166)
- Recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) shortens the period of neutropenia after autologous bone marrow transplantation in a primate model. (1987) (166)
- Defective paracrine signalling by TGFβ in yolk sac vasculature of endoglin mutant mice: a paradigm for hereditary haemorrhagic telangiectasia (2004) (163)
- Hoxb4-deficient mice undergo normal hematopoietic development but exhibit a mild proliferation defect in hematopoietic stem cells. (2004) (163)
- Targeted deletion of the TGF-beta 1 gene causes rapid progression to squamous cell carcinoma. (1994) (162)
- Targeted Disruption of the Ribosomal Protein S19 Gene Is Lethal Prior to Implantation (2004) (160)
- Cripto regulates hematopoietic stem cells as a hypoxic-niche-related factor through cell surface receptor GRP78. (2011) (159)
- Murine models of acute neuronopathic Gaucher disease (2007) (157)
- Developmental regulation of human globin genes. (1985) (156)
- Inactivation of TGFbeta signaling in neural crest stem cells leads to multiple defects reminiscent of DiGeorge syndrome. (2005) (151)
- Epithelial and ectomesenchymal role of the type I TGF-beta receptor ALK5 during facial morphogenesis and palatal fusion. (2006) (147)
- Reduced Proliferative Capacity of Hematopoietic Stem Cells Deficient in Hoxb3 and Hoxb4 (2003) (143)
- Smad4 is critical for self-renewal of hematopoietic stem cells (2007) (136)
- Brain area-specific effect of TGF-beta signaling on Wnt-dependent neural stem cell expansion. (2008) (133)
- Deficiency of ribosomal protein S19 in CD34+ cells generated by siRNA blocks erythroid development and mimics defects seen in Diamond-Blackfan anemia. (2005) (128)
- Compound developmental eye disorders following inactivation of TGFβ signaling in neural-crest stem cells (2005) (128)
- Mice with ribosomal protein S19 deficiency develop bone marrow failure and symptoms like patients with Diamond-Blackfan anemia. (2011) (127)
- Effective cell and gene therapy in a murine model of Gaucher disease (2006) (126)
- Hematopoietic stem cell responsiveness to exogenous signals is limited by caspase-3. (2008) (123)
- Intact signaling by transforming growth factor β is not required for termination of liver regeneration in mice (2004) (120)
- Lentiviral gene transfer into primary and secondary NOD/SCID repopulating cells. (2000) (119)
- HOXA10 is a critical regulator for hematopoietic stem cells and erythroid/megakaryocyte development. (2007) (118)
- Complex and Context Dependent Regulation of Hematopoiesis by TGF‐β Superfamily Signaling (2009) (116)
- Cytokine-Induced Src Homology 2 Protein (Cis) Promotes T Cell Receptor–Mediated Proliferation and Prolongs Survival of Activated T Cells (2000) (116)
- Development of an adenoviral vector system with adenovirus serotype 35 tropism; efficient transient gene transfer into primary malignant hematopoietic cells (2004) (116)
- Lentivirus Vector Gene Expression during ES Cell-Derived Hematopoietic Development In Vitro (2000) (114)
- Decreased metastatic spread in mice homozygous for a null allele of the cystatin C protease inhibitor gene. (1999) (111)
- The role of Smad signaling in hematopoiesis and translational hematology (2011) (109)
- Expression of the human beta-globin gene following retroviral-mediated transfer into multipotential hematopoietic progenitors of mice. (1988) (105)
- Fetal gene therapy for neurodegenerative disease of infants (2018) (104)
- Connective tissue growth factor expression and Smad signaling during mouse heart development and myocardial infarction (2004) (101)
- Diamond-Blackfan anemia: erythropoiesis lost in translation. (2007) (97)
- Synthetic fibronectin peptides interrupt inflammatory cell infiltration in transforming growth factor beta 1 knockout mice. (1994) (93)
- Gene transfer improves erythroid development in ribosomal protein S19-deficient Diamond-Blackfan anemia. (2002) (89)
- Correction of glucocerebrosidase deficiency after retroviral-mediated gene transfer into hematopoietic progenitor cells from patients with Gaucher disease. (1990) (88)
- Smad7 promotes self-renewal of hematopoietic stem cells. (2006) (82)
- Dietary L-leucine improves the anemia in a mouse model for Diamond-Blackfan anemia. (2012) (82)
- High levels of human glucocerebrosidase activity in macrophages of long-term reconstituted mice after retroviral infection of hematopoietic stem cells. (1992) (79)
- Altered expression and distribution of cathepsins in neuronopathic forms of Gaucher disease and in other sphingolipidoses. (2010) (76)
- Growth factors and stromal support generate very efficient retroviral transduction of peripheral blood CD34+ cells from Gaucher patients. (1995) (76)
- Ribosomal Protein S19 Deficiency Leads to Reduced Proliferation and Increased Apoptosis but Does Not Affect Terminal Erythroid Differentiation in a Cell Line Model of Diamond‐Blackfan Anemia (2008) (72)
- Retroviral-mediated transfer of genomic globin genes leads to regulated production of RNA and protein. (1987) (72)
- Dppa5 improves hematopoietic stem cell activity by reducing endoplasmic reticulum stress. (2014) (72)
- Beta 2-microglobulin-deficient background ameliorates lethal phenotype of the TGF-beta 1 null mouse. (1999) (72)
- Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma (2016) (69)
- Smad2/Smad3 in endothelium is indispensable for vascular stability via S1PR1 and N-cadherin expressions. (2012) (65)
- High levels of the adhesion molecule CD44 on leukemic cells generate acute myeloid leukemia relapse after withdrawal of the initial transforming event (2010) (63)
- Inhibition of UDP‐glucosylceramide synthase in mice prevents Gaucher disease‐associated B‐cell malignancy (2015) (61)
- Quiescence of hematopoietic stem cells and maintenance of the stem cell pool is not dependent on TGF-beta signaling in vivo. (2005) (61)
- Canonical BMP signaling is dispensable for hematopoietic stem cell function in both adult and fetal liver hematopoiesis, but essential to preserve colon architecture. (2010) (61)
- Lentiviral gene therapy using cellular promoters cures type 1 Gaucher disease in mice. (2015) (61)
- Proliferation of primitive myeloid progenitors can be reversibly induced by HOXA10. (2001) (59)
- Production of glycosylated physiologically "normal" human alpha 1-antitrypsin by mouse fibroblasts modified by insertion of a human alpha 1-antitrypsin cDNA using a retroviral vector. (1987) (59)
- Mouse and rat cystatin C: Escherichia coli production, characterization and tissue distribution. (1996) (58)
- A Human IPS Model Implicates Embryonic B-Myeloid Fate Restriction as Developmental Susceptibility to B Acute Lymphoblastic Leukemia-Associated ETV6-RUNX1 (2017) (58)
- Selection of transduced CD34+ progenitors and enzymatic correction of cells from Gaucher patients, with bicistronic vectors. (1995) (57)
- Development of cellular models for ribosomal protein S19 (RPS19)-deficient diamond-blackfan anemia using inducible expression of siRNA against RPS19. (2005) (57)
- Long-term in vivo expression of the human glucocerebrosidase gene in nonhuman primates after CD34+ hematopoietic cell transduction with cell-free retroviral vector preparations. (1995) (57)
- A critical developmental role for tgfbr2 in myogenic cell lineages is revealed in mice expressing SM22-Cre, not SMMHC-Cre. (2006) (56)
- Glucosylated cholesterol in mammalian cells and tissues: formation and degradation by multiple cellular β-glucosidases[S] (2016) (56)
- Hoxa9/hoxb3/hoxb4 compound null mice display severe hematopoietic defects. (2007) (56)
- Proliferation deficiency of multipotent hematopoietic progenitors in ribosomal protein S19 (RPS19)-deficient diamond-Blackfan anemia improves following RPS19 gene transfer. (2003) (54)
- A Road Map Toward Defining the Role of Smad Signaling in Hematopoietic Stem Cells (2006) (54)
- Transient Disruption of Autocrine TGF-β Signaling Leads to Enhanced Survival and Proliferation Potential in Single Primitive Human Hemopoietic Progenitor Cells1 (2002) (52)
- Correction of the enzyme deficiency in hematopoietic cells of Gaucher patients using a clinically acceptable retroviral supernatant transduction protocol. (1994) (52)
- Analysis of Hornozygous TGFβ1 Null Mouse Embryos Demonstrates Defects in Yolk Sac. Vasculogenesis and Hematopoiesis (1995) (51)
- Transfer of genes into hematopoietic cells using recombinant DNA viruses. (1985) (49)
- No evidence for activation of the unfolded protein response in neuronopathic models of Gaucher disease. (2009) (49)
- A bicistronic therapeutic retroviral vector enables sorting of transduced CD34+ cells and corrects the enzyme deficiency in cells from Gaucher patients. (1996) (49)
- Enforced adenoviral vector-mediated expression of HOXB4 in human umbilical cord blood CD34+ cells promotes myeloid differentiation but not proliferation. (2003) (47)
- Structural organization, expression and chromosomal mapping of the mouse cystatin-C-encoding gene (Cst3) (1995) (47)
- Combining CAR T cells and the Bcl-2 family apoptosis inhibitor ABT-737 for treating B-cell malignancy (2013) (46)
- Promoter sequences required for function of the human gamma globin gene in erythroid cells. (1986) (45)
- Lentivirus Gene Transfer in Murine Hematopoietic Progenitor Cells Is Compromised by a Delay in Proviral Integration and Results in Transduction Mosaicism and Heterogeneous Gene Expression in Progeny Cells (2000) (45)
- Hematopoietic stem cell-targeted neonatal gene therapy reverses lethally progressive osteopetrosis in oc/oc mice. (2007) (45)
- The tetraspanin CD9 affords high-purity capture of all murine hematopoietic stem cells. (2013) (44)
- HOXB4‐Induced Self‐Renewal of Hematopoietic Stem Cells Is Significantly Enhanced by p21 Deficiency (2006) (43)
- Development of gene therapy for hematopoietic stem cells using lentiviral vectors (2002) (43)
- Alkaline pH Is a Signal for Optimal Production and Secretion of the Heat Labile Toxin, LT in Enterotoxigenic Escherichia Coli (ETEC) (2013) (43)
- Transfer of the human glucocerebrosidase gene into hematopoietic stem cells of nonablated recipients: successful engraftment and long-term expression of the transgene. (1995) (43)
- B cell lymphoma and myeloma in murine Gaucher's disease (2013) (43)
- Erythropoiesis in the Rps19 disrupted mouse: Analysis of erythropoietin response and biochemical markers for Diamond-Blackfan anemia. (2006) (41)
- Production of human glucocerebrosidase in mice after retroviral gene transfer into multipotential hematopoietic progenitor cells. (1989) (41)
- Inflammation and TGF beta 1: lessons from the TGF beta 1 null mouse. (1997) (40)
- Stable gene transfer and tissue‐specific expression of a human globin gene using adenoviral vectors. (1986) (40)
- Retroviral vector design for long-term expression in murine hematopoietic cells in vivo. (1994) (39)
- Successful Low‐Risk Hematopoietic Cell Therapy in a Mouse Model of Type 1 Gaucher Disease (2009) (39)
- Functionally distinct subpopulations of cord blood CD34+ cells are transduced by adenoviral vectors with serotype 5 or 35 tropism. (2004) (39)
- Gene therapy of Diamond Blackfan anemia CD34(+) cells leads to improved erythroid development and engraftment following transplantation. (2008) (39)
- TGF-beta type II receptor-deficient thymocytes develop normally but demonstrate increased CD8+ proliferation in vivo. (2005) (39)
- A two-year dietary carcinogenicity study of the antiestrogen toremifene in Sprague-Dawley rats. (1996) (38)
- Smad5 is dispensable for adult murine hematopoiesis. (2006) (38)
- Neonatal hematopoietic stem cell transplantation cures oc/oc mice from osteopetrosis. (2006) (35)
- Initiating activity of the anti-estrogen tamoxifen, but not toremifene in rat liver. (1997) (34)
- Smad4 binds Hoxa9 in the cytoplasm and protects primitive hematopoietic cells against nuclear activation by Hoxa9 and leukemia transformation. (2011) (34)
- Lentiviral‐mediated gene transfer into haematopoietic stem cells (2001) (32)
- Female mice are more susceptible to developing inflammatory disorders due to impaired transforming growth factor beta signaling in salivary glands. (2007) (32)
- Gene expression profiling demonstrates that TGF-β1 signals exclusively through receptor complexes involving Alk5 and identifies targets of TGF-β signaling (2005) (32)
- TGFβ Receptor I Conditional Knockout Mice Develop Spontaneous Squamous Cell Carcinoma (2007) (31)
- Increased glucocerebrosidase (GBA) 2 activity in GBA1 deficient mice brains and in Gaucher leucocytes (2013) (31)
- Disruption of the 5S RNP–Mdm2 interaction significantly improves the erythroid defect in a mouse model for Diamond-Blackfan anemia (2015) (31)
- Retroviral-mediated gene transfer into mammalian cells. (1987) (30)
- The Proliferation in Uterine Compartments of Intact Rats of Two Different Strains Exposed to High Doses of Tamoxifen or Toremifene (1998) (30)
- Functional and genetic characterization of the non-lysosomal glucosylceramidase 2 as a modifier for Gaucher disease (2013) (29)
- Viral vectors for gene therapy of hematopoietic cells. (1997) (29)
- Comparison of the effects of tamoxifen and toremifene on rat hepatocarcinogenesis (2000) (29)
- A new moderately repetitive DNA sequence family of novel organization. (1987) (28)
- Gene therapy cures the anemia and lethal bone marrow failure in a mouse model of RPS19-deficient Diamond-Blackfan anemia (2014) (28)
- TGF-β as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation. Commentary (2009) (27)
- Retroviral vector design for long-term expression in murine hematopoietic cells in vivo (1994) (26)
- Hematopoietic stem cells are regulated by Cripto, as an intermediary of HIF‐1α in the hypoxic bone marrow niche (2012) (26)
- Expression of human glucocerebrosidase in long-term reconstituted mice following retroviral-mediated gene transfer into hematopoietic stem cells. (1990) (25)
- Adenoviral vector design for high-level transgene expression in primitive human hematopoietic progenitors (2000) (25)
- Retroviral transduction of human CD34+ cells on fibronectin fragment CH‐296 is inhibited by high concentrations of vector containing medium (2001) (24)
- Development of gene therapy for blood disorders by gene transfer into haematopoietic stem cells (2002) (24)
- Enforced expression of cyclin D2 enhances the proliferative potential of myeloid progenitors, accelerates in vivo myeloid reconstitution, and promotes rescue of mice from lethal myeloablation. (2004) (24)
- Human RPS 19 , the gene mutated in Diamond-Blackfan anemia , encodes a ribosomal protein required for the maturation of 40 S ribosomal subunits (2007) (24)
- SPARC is dispensable for murine hematopoiesis, despite its suspected pathophysiological role in 5q-myelodysplastic syndrome (2012) (24)
- Genotoxicity studies with the antiestrogen toremifene. (1998) (23)
- Gene expression profiling demonstrates that TGF-beta1 signals exclusively through receptor complexes involving Alk5 and identifies targets of TGF-beta signaling. (2005) (23)
- Clinical, pathologic, and ultrastructural features of situs inversus and immotile-cilia syndrome in a dog. (1984) (23)
- Clinical Gene Therapy in Hematology: Past and Future (2001) (23)
- Successful treatment of metachromatic leukodystrophy using bone marrow transplantation of HoxB4 overexpressing cells. (2010) (22)
- Efficient adenoviral vector transduction of human hematopoietic SCID-repopulating and long-term culture-initiating cells. (2000) (22)
- Poor vessel formation in embryos from knock-in mice expressing ALK5 with L45 loop mutation defective in Smad activation (2009) (21)
- Human hematopoietic stem/progenitor cells overexpressing Smad4 exhibit impaired reconstitution potential in vivo. (2012) (20)
- Endoglin Is Not Critical for Hematopoietic Stem Cell Engraftment and Reconstitution but Regulates Adult Erythroid Development (2007) (20)
- Efficient Characterization of Retro‐, Lenti‐, and Foamyvector‐Transduced Cell Populations by High‐Accuracy Insertion Site Sequencing (2003) (20)
- Glucocorticoids improve erythroid progenitor maintenance and dampen Trp53 response in a mouse model of Diamond–Blackfan anaemia (2015) (19)
- The SKI proto-oncogene enhances the in vivo repopulation of hematopoietic stem cells and causes myeloproliferative disease (2014) (19)
- Gene transfer and bone marrow transplantation with special reference to Gaucher's disease. (1993) (17)
- Gene transfer and expression in nonhuman primates using retroviral vectors. (1986) (17)
- Lentiviral Vectors with Cellular Promoters Correct Anemia and Lethal Bone Marrow Failure in a Mouse Model for Diamond-Blackfan Anemia. (2017) (17)
- ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor Immunity (2018) (17)
- TGF-b signaling in the control of hematopoietic stem cells (2015) (17)
- No discrepancy between in vivo gene marking efficiency assessed in peripheral blood populations compared with bone marrow progenitors or CD34+ cells. (1999) (15)
- Induction of Endometrial Cancer by Tamoxifen in the Rat (1996) (15)
- Poor transduction efficiency of human hematopoietic progenitor cells by a high-titer amphotropic retrovirus producer cell clone (1994) (14)
- Expression from polycistronic cauliflower mosaic virus pregenomic RNA (1990) (13)
- Hoxb 4-deficient mice undergo normal hematopoietic development but exhibit a mild proliferation defect in hematopoietic stem cells (2004) (13)
- Stem cell regulation and host defense: the logic and the paradox. (2008) (13)
- Adenoviral vectors for transient gene expression in human primitive hematopoietic cells: applications and prospects. (2007) (12)
- Gene therapy of haematopoietic cells (1997) (12)
- Angptl4 maintains in vivo repopulation capacity of CD34+ human cord blood cells (2012) (12)
- Inactivation of TGFb receptors in stem cells drives cutaneous squamous cell carcinoma (2016) (12)
- Oncoretroviral gene transfer to NOD/SCID repopulating cells using three different viral envelopes (2002) (12)
- Histopathology and histomorphometry of the urogenital tract in 15-month old male and female rats treated neonatally with SERMs and estrogens. (2006) (12)
- Expression of human glucocerebrosidase in murine macrophages: identification of efficient retroviral vectors. (1994) (10)
- The combination of IL-3 and IL-6 enhances retrovirus mediated gene transfer into hematopoietic stem cells. (1990) (10)
- Efficient oncoretroviral transduction of extended long-term culture-initiating cells and NOD/SCID repopulating cells: enhanced reconstitution with gene-marked cells through an ex vivo expansion approach. (2002) (10)
- Correction of pathology in mice displaying Gaucher disease type 1 by a clinically-applicable lentiviral vector (2020) (10)
- Selection of retrovirally transduced cells to enhance the efficiency of gene therapy. (1997) (10)
- The use of 35S RNA as either messenger or replicative intermediate might control the cauliflower mosaic virus replication cycle (1990) (10)
- S100A6 is a critical regulator of hematopoietic stem cells (2020) (9)
- Neuron-specific TGF-beta signaling deficiency results in retinal detachment and cataracts in mice. (2007) (9)
- The stem cell regulator PEDF is dispensable for maintenance and function of hematopoietic stem cells (2017) (8)
- Evaluation of expression of transferred genes in differentiating myeloid cells: expression of human glucocerebrosidase in murine macrophages. (1993) (8)
- Single-cell transcriptional profiling informs efficient reprogramming of human somatic cells to cross-presenting dendritic cells (2022) (8)
- 61 Endometrial cancer induction by tamoxifen in the rat (1995) (7)
- Cis-acting sequences that affect the expression of the human fetal gamma-globin genes. (1985) (7)
- Successful gene therapy of Diamond-Blackfan anemia in a mouse model and human CD34+ cord blood hematopoietic stem cells using a clinically applicable lentiviral vector (2021) (7)
- Stem cell expansion: success and complexities (2004) (7)
- The effect of toremifene on bone and uterine histology and on bone resorption in ovariectomised rats. (1999) (7)
- Towards therapy of Gaucher's disease by gene transfer into hematopoietic cells (1994) (7)
- Combining CAR T cells and the Bcl-2 family apoptosis inhibitor ABT-737 for treating B-cell malignancy (2013) (7)
- A network including TGFβ/Smad4, Gata2, and p57 regulates proliferation of mouse hematopoietic progenitor cells. (2016) (7)
- Cripto Regulates Hematopoietic Stem Cells As a Hypoxic Niche Related Factor Through the Cell Surface Receptor GRP78 (2011) (6)
- Smad 4 is critical for self-renewal of hematopoietic stem cells (2007) (6)
- Retroviral-mediated gene transfer into hematopoietic cells. (1986) (6)
- β2-Microglobulin-Deficient Background Ameliorates Lethal Phenotype of the TGF-β1 Null Mouse (1999) (6)
- Tipping Clonal Hematopoiesis into Transformation (2018) (5)
- Is TGF-beta a stemness regulator? (2009) (5)
- Disruption of the 5 S RNP-Mdm 2 interaction significantly improves the erythroid defect in a mouse model for Diamond-Blackfan anemia (2015) (5)
- A Human IPS Model Implicates Embryonic B-Myeloid Fate Restriction as Developmental Susceptibility to B Acute Lymphoblastic Leukemia-Associated ETV 6-RUNX 1 Highlights (2017) (5)
- The Tetraspanin CD 9 Affords High-Purity Capture of All Murine Hematopoietic Stem Cells (2013) (5)
- BMP signaling is required for postnatal murine hematopoietic stem cell self-renewal (2020) (5)
- Bone Marrow Failure in RPS19-Deficient Mice Is Partly Caused by p53 Activation and Responds to L-Leucine Treatment (2011) (5)
- A Novel Mouse Model for RPS19-Deficient Diamond-Blackfan Anemia Locates the Erythroid Defect at CFU-E/Proerythroblast Transition (2009) (4)
- Introduction and expression of human beta globin genes into primitive murine hematopoietic progenitor cells by retrovirus mediated gene transfer. (1989) (4)
- Expression of human beta globin genes introduced into primitive murine hematopoietic progenitor cells by retrovirus mediated gene transfer. (1989) (4)
- Smad 7 promotes self-renewal of hematopoietic stem cells (2006) (4)
- Karlsson transfer Treatment of genetic defects in hematopoietic cell function by gene (1991) (3)
- Locus-Control-Region-Coupled Beta (S)(Antilles)- and Alpha(2)-Hemoglobin Genes Select for High Alpha(2)-Hemoglobin Expression in Adult Transgenic Mice. (1994) (3)
- Targeted deletion of the TGF-pi gene causes rapid progression to squamous cell carcinoma (2007) (3)
- Hematopoietic Stem Cells Overexpressing Smad7 Exhibit Increased Self-Renewal and Regeneration Capacity in Vivo. (2004) (3)
- SMAD4 Sequestrates HOXA9 to Protect Hematopoietic Stem Cells Against Leukemia Transformation (2010) (3)
- Signaling via Smad2 and Smad3 is dispensable for adult murine hematopoietic stem cell function in vivo. (2017) (3)
- Connecting ribosomes with bone marrow failure (2007) (3)
- Chronic RPS19 Deficiency Leads to Bone Marrow Failure In a Mouse Model for Diamond Blackfan Anemia (2010) (3)
- High levels of CD44 on leukemic cells generate AML relapse after withdrawal of the initial transforming event (2010) (2)
- Common signaling networks characterize leukemia-initiating cells in acute myeloid leukemia. (2012) (2)
- Roscoe Owen Brady, MD: Remembrances of co-investigators and colleagues. (2017) (2)
- Glucocorticoids Reduce Expression Of p53 Target Genes and Reverse Anemia In a Mouse Model Of Diamond-Blackfan Anemia (2013) (2)
- Hematopoietic Stem Cell Expansion by HOXB4 Is Greatly Enhanced in p21 Deficient Stem Cells. (2004) (2)
- Development of gene therapy for hematopoietic stem cells (2002) (2)
- First-in-Class Small Molecule to Inhibit CYP11A1 And Steroid Hormone Biosynthesis. (2022) (2)
- Retroviral Vector‐mediated Gene Transfer and Expression in Nonhuman Primates Following Autologous Bone Marrow Transplantation a (1987) (2)
- TGF-type II receptor – deficient thymocytes develop normally but demonstrate increased CD 8 proliferation in vivo (2005) (2)
- Gene therapy: efficient targeting of hematopoietic stem cells (2005) (1)
- exhibit a mild proliferation defect in hematopoietic stem cells Hoxb4-deficient mice undergo normal hematopoietic development but (2013) (1)
- A HOXA10-inducible mouse model demonstrates an important role of the initial transforming event in the maintenance of the leukemia (2008) (1)
- HOXA10 Affects the Fate of Hematopoietic Progenitors and Stem Cells in a Concentration Dependent Manner. (2004) (1)
- NON-canonical BMP signaling is required for postnatal hematopoietic stem cell self-renewal (2016) (1)
- Apoptotic Change Is a Major Reason for Defect in Early Erythroid Development in Cell Line Models for Ribosomal Protein (RP) S19 Deficient Diamond-Blackfan Anemia. (2004) (1)
- Erratum to: Increased glucocerebrosidase (GBA) 2 activity in GBA1 deficient mice brains and in Gaucher leucocytes (2013) (1)
- Characterization of Urothelial Inclusions in Male Wistar Han Rats Treated Orally With the Novel α2A-Adrenoceptor Agonist Tasipimidine (2021) (1)
- Correction: S100A6 is a critical regulator of hematopoietic stem cells (2020) (1)
- Regulated expression of human globin genes following transfer with retroviral vectors. (1987) (1)
- ICLAS proceedings: New histopathologic and histokinetic methods in preclinical safety studies (1996) (1)
- Smad4 as a therapeutic target in hoxa9-related leukemia (2009) (1)
- Bone marrow transplantation without myeloablative conditioning in a mouse model for Diamond-Blackfan Anemia corrects the disease phenotype. (2021) (1)
- 96. Enforced HoxB4 Expressed Hematopoietic Stem Cells Transdifferentiate into Oligodendrocytes in Adult Mouse Brain (2006) (1)
- The first steps on the gene therapy pathway to anti-sickling success (2000) (1)
- Schlafen2 is a critical regulator of adult hematopoietic stem cells (2016) (1)
- High Levels of HoxA10 Severely Impair Erythoid Development In Vivo and Cause Lethal Anemia. (2004) (1)
- Development of novel therapies in murine models for Gaucher disease (2009) (0)
- Impact of selective inactivation of transforming growth factor-beta type II receptor gene (TGFBR2) during viral hepatitis (2001) (0)
- 432 ODM-203, a novel, selective and balanced FGFR and VEGFR inhibitor with strong anti-tumor activity in FGFR- and VEGFR-dependent cancer models (2014) (0)
- Smad4 as a Therapeutic Target in Nup98-HoxA9-Induced Leukemia. (2008) (0)
- In an inducible model of acute myeloid leukemia, secondary hits are required to generate a leukemia relapse after removal of the initial transforming event (2009) (0)
- A Critical Role for BMP Signaling in Adult Hematopoietic Stem Cells (2012) (0)
- Reduction in endoplasmic reticulum (ER) stress enables maintenance of functional hematopoietic stem cells in vitro (2013) (0)
- [Successful gene therapy of children with severe immunodeficiency. Research breakthrough hopefully for the treatment of other diseases, too]. (2002) (0)
- 113 Mice with hepatocye-specific disruption of transforming growth factor beta (TGF-β) signaling have enhanced mitogenic response during liver regeneration (2003) (0)
- Quantitative Mass Spectrometry Imaging ( QMSI ) as a tool to study a new Anticancer Drug and its Metabolites in Tumor Bearing Mice (2017) (0)
- PEDF regulates hematopoietic stem cell maintenance (2014) (0)
- Hematopoietc Stem Cell Targeted Neonatal Gene Therapy Cures oc/oc Mice from Osteopetrosis. (2006) (0)
- Perinatal gene therapy ameliorates a mouse model of neuronopathic Gaucher disease (2014) (0)
- Safe lentiviral vectors with cellular and myeloid promoters driving glucocylceramidase expression corrects type 1 gaucher disease (2014) (0)
- Abstract 1506: Frequent loss of function mutations in TGFβR1 and TGFβR2 identify hair follicle bulge stem cells as the cell of origin for cutaneous squamous cell carcinoma (2015) (0)
- Sparc Is Dispensable for Murine Hematopoiesis, Despite Its Suspected Role in 5q- Myelodysplastic Syndrome (2011) (0)
- transplantable receptor gene in mice causes a lethal inflammatory disorder that is Induced disruption of the transforming growth factor beta type II (2010) (0)
- Commentary Transforming Growth Factor-f31 Knockout Mice A Mutation in One Cytokine Gene Causes a Dramatic Inflammatory Disease (2007) (0)
- Critical Role of TGF-beta Signaling Pathways in Skeletal Development (2008) (0)
- Lipocalin 2 negatively controls erythroid and macrophage lineages via megalin as its receptor (2009) (0)
- Therapeutic effects of bone marrow transplantation for metachromatic leukodystrophy using HOXB4 over-expressing cells (2008) (0)
- 900. Development of models for RPS19 deficient diamond-blackfan anemia using regulatable expression of siRNA against RPS19 (2004) (0)
- Gata2 Is a Direct Target for Smad-Mediated TGFβ Signaling in Hematopoietic Stem/Progenitor Cells (2011) (0)
- HOXA10 Proliferation of primitive myeloid progenitors can be reversibly induced by (2013) (0)
- Hematopoietic Stem Cell Transplantation Cures Oc/Oc Mice from Osteopetrosis. (2004) (0)
- B cell lymphoma and myeloma in murine Gaucher's disease. J Pathol 2013; 231: 88–97 (2013) (0)
- IDENTIFICATION OF A TRANSCRIPTIONAL REGULATORY NETWORK BETWEEN TGF beta/SMAD4, GATA2 AND P57 IN HEMATOPOIETIC STEM/PROGENITOR CELLS (2014) (0)
- Lentiviral gene transfer into nod/scid repopulating cells results in monoclonal hematopoiesis with transduced myeloid and lymphoid progeny (2000) (0)
- Fetal Gene Therapy for Acute Neuronopathic Gaucher Disease (2009) (0)
- Gene Therapy Corrects the Lethal Bone Marrow Failure in a Mouse Model for RPS19-Deficient Diamond-Blackfan Anemia (2012) (0)
- Impaired Reconstitution Potential of TGFβ-Hypersensitive Human Hematopoietic Stem Cells (2011) (0)
- Del(5q) Myelodysplastic Stem Cells Exhibit Their Clonal Advantage Via Increased Adhesion to the Microenvironment (2011) (0)
- In utero gene therapy rescue of an acute neonatal lethal mouse model of neuropathic Gaucher Disease (2013) (0)
- Defective Ribosomal RNA Maturation in Patients with Diamond Blackfan Anemia. (2006) (0)
- [Setback for gene therapy: Two cases of leukemia in a French trial]. (2003) (0)
- Stress hematopoiesis requires Erg. (2011) (0)
- Developmental Pluripotency Associated 5 (Dppa5) Regulates Hematopoietic Stem Cell Reconstitution Capacity by Modulating Cellular Metabolism and ER Stress (2012) (0)
- Signal transduction of multifunctional TGF-ß family members (2008) (0)
- Diamond-Blackfan anemia blocks erythroid development and mimics defects seen in Deficiency of ribosomal protein S19 in CD34+ cells generated by siRNA (2013) (0)
- Global Gene Expression Analysis Demonstrates that Transforming Growth Factor β1 (TGF-β1) Signals Exclusively through Receptor Complexes Involving TGF-β Receptor I and Identifies Numerous Targets of TGF-β Signaling. (2004) (0)
- BMPR1a is required for the optimal TGF-β1 dependent CD207+ Langerhans cell differentiation and limits skin inflammation via CD11c+ cells. (2022) (0)
- erythroid/megakaryocyte development HOXA10 is a critical regulator for hematopoietic stem cells and (2013) (0)
- Clinical Applications of Gene Therapy: Correction of Genetic Disease Affecting Hematopoietic Cells (2002) (0)
- Cripto Selectively Expands a Distinct Population Of Hematopoietic Stem Cells Expressing Cell Surface Receptor GRP78 (2010) (0)
- Hematopoietic Mechanism in Diamond-Blackfan Anemia: Late Erythroid Development Is Not Affected by Ribosomal Protein S19 Deficiency. (2004) (0)
- Expression in Progeny Cells Mosaicism and Heterogeneous Gene Integration and Results in Transduction Compromised by a Delay in Proviral Hematopoietic Progenitor Cells Is Lentivirus Gene Transfer in Murine (2000) (0)
- The stem cell regulator PEDF is dispensable for maintenance and function of hematopoietic stem cells (2017) (0)
- Human Hemopoietic Progenitor Cells Proliferation Potential in Single Primitive Signaling Leads to Enhanced Survival and b Transient Disruption of Autocrine TGF-Dijke (2001) (0)
- lethally progressive osteopetrosis in oc/oc mice targeted neonatal gene therapy reverses - Hematopoietic stem cell (2013) (0)
- Diamond-Blackfan Anemia: Erythropoiesis Lost in Ribosome Biosynthesis (2011) (0)
- Transfer of genes in hematopoietic cells with retroviral vectors. (1988) (0)
- Abstract 4133: ODM-203, a novel, selective and balanced FGFR and VEGFR inhibitor with strong activity on primary and metastatic tumor growth in FGFR-dependent and angiogenic cancer models (2015) (0)
- Schlafen2 is a regulator of quiescence in adult murine hematopoietic stem cells (2022) (0)
- High-titer lentivirus mediated gene transfer introduces multiple vector copies into the genome of primate and human hematopoietic repopulating cells (2001) (0)
- A human ips model implicates embryonic B-myeloid fate restriction as a developmental susceptibility to ETV6-RUNX1 (2017) (0)
- Expression of the human f 8-globin gene following retroviral-mediated transfer into multipotential hematopoietic progenitors of mice ( retroviral vectors / gene regulation / colony-forming units , spleen / stem cells / gene therapy ) (0)
- Deficient Ribosomal Protein S19 in Diamond-Blackfan Anemia Causes a Reduction in bcl-2 and Bad and Leads to Apoptosis in Erythroid Progenitor Cells. (2005) (0)
- A critical role for Smad4 in the self-renewal of hematopoietic stem cells (2008) (0)
- Enforced expression of c-Ski in adult murine hematopoiesis promotes myeloid - Differentiation, revealing an important role for c-Ski in governing hematopoietic cell fate options (2008) (0)
- Abstract 1753: Targeting cancer with selective cbp/p300 bromodomain inhibitors (2020) (0)
- proliferation, migration, and NOD/SCID repopulation Overexpression of CXCR4 on human CD34+ progenitors increases their (2013) (0)
- Enforced expression of RPS19 derived from human elongation factor 1A short (EFS) promoter corrects the anemia and lethal bone marrow failure in mouse model for RPS19-deficient diamond-blackfan anemia (2015) (0)
- Does ribosomal protein-Mdm2 interaction mediate the p53-dependent hematopoietic defect in diamond-blackfan anemia? (2013) (0)
- Inactivation of transforming growth factor-beta receptors in human cutaneous squamous cell carcinoma and murine hair follicle stem cells drives tumorigenesis. (2016) (0)
- Intravenously administered gene therapy for the treatment of neuronopathic Gaucher Disease (2016) (0)
- Fetal gene therapy for neurodegenerative disease of infants (2018) (0)
- Isolation and Characterization of Living Cord Blood CD34+ Cells with Telomerase Reverse Transcriptase (TERT) Expression. (2004) (0)
- Transforming growth factor 181 null mutation in mice causes excessive inflammatory response and early death (homologous recombination/embryonc stem cells/in (2004) (0)
- Cripto Selectively Expands a Distinct Population of Hematopoietic Stem Cells Expressing the Cell Surface Receptor GRP78 and Strongly Induces An Immature Phenotype In Vivo After Ex Vivo Culture (2010) (0)
- Schlafen2 regulates the regenerative capacity of adult HSCs (2014) (0)
- Abstract 2692: ETV6-RUNX1 targets a developmentally restricted embryonic human B-myeloid progenitor (2016) (0)
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What Schools Are Affiliated With Stefan Karlsson?
Stefan Karlsson is affiliated with the following schools:
