Stefano Fiorucci
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Researcher ORCID: 0000-0003-3816-4222
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Physics
Stefano Fiorucci's Degrees
- PhD Physics University of Milan
- Masters Physics University of Milan
- Bachelors Physics University of Milan
Why Is Stefano Fiorucci Influential?
(Suggest an Edit or Addition)Stefano Fiorucci's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Hydrogen sulfide is an endogenous modulator of leukocyte‐mediated inflammation (2006) (815)
- 6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity. (2002) (656)
- The third gas: H2S regulates perfusion pressure in both the isolated and perfused normal rat liver and in cirrhosis (2005) (491)
- The Bile Acid Receptor FXR Is a Modulator of Intestinal Innate Immunity1 (2009) (460)
- The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis. (2004) (411)
- Inhibition of hydrogen sulfide generation contributes to gastric injury caused by anti-inflammatory nonsteroidal drugs. (2005) (403)
- The emerging roles of hydrogen sulfide in the gastrointestinal tract and liver. (2006) (364)
- FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats[S] (2010) (350)
- Bile Acid-Activated Receptors, Intestinal Microbiota, and the Treatment of Metabolic Disorders. (2015) (312)
- Bile-acid-activated receptors: targeting TGR5 and farnesoid-X-receptor in lipid and glucose disorders. (2009) (292)
- The Bile Acid Receptor GPBAR-1 (TGR5) Modulates Integrity of Intestinal Barrier and Immune Response to Experimental Colitis (2011) (283)
- Dual inhibitors of cyclooxygenase and 5-lipoxygenase. A new avenue in anti-inflammatory therapy? (2001) (282)
- Evidence That Hydrogen Sulfide Exerts Antinociceptive Effects in the Gastrointestinal Tract by Activating KATP Channels (2006) (254)
- Gastrointestinal safety and anti-inflammatory effects of a hydrogen sulfide-releasing diclofenac derivative in the rat. (2007) (251)
- Bile Acids Activated Receptors Regulate Innate Immunity (2018) (248)
- Galectin-1 suppresses experimental colitis in mice. (2003) (247)
- Gut microbiota role in irritable bowel syndrome: New therapeutic strategies. (2016) (243)
- Gastrointestinal safety of NO-aspirin (NCX-4016) in healthy human volunteers: a proof of concept endoscopic study. (2003) (234)
- Enhanced activity of a hydrogen sulphide‐releasing derivative of mesalamine (ATB‐429) in a mouse model of colitis (2007) (204)
- Proteinase-activated receptor 2 is an anti-inflammatory signal for colonic lamina propria lymphocytes in a mouse model of colitis (2001) (195)
- Pentoxifylline prevents indomethacin induced acute gastric mucosal damage in rats: role of tumour necrosis factor alpha. (1994) (194)
- Protective Effects of 6-Ethyl Chenodeoxycholic Acid, a Farnesoid X Receptor Ligand, in Estrogen-Induced Cholestasis (2005) (186)
- Modulation of Intestinal Microbiota by the Probiotic VSL#3 Resets Brain Gene Expression and Ameliorates the Age-Related Deficit in LTP (2014) (178)
- Gastrointestinal safety of nitric oxide-derived aspirin is related to inhibition of ICE-like cysteine proteases in rats. (1999) (176)
- Endothelial nitric oxide synthase: the Cinderella of inflammation? (2003) (173)
- Targeting farnesoid X receptor for liver and metabolic disorders. (2007) (173)
- Galectin‐1 exerts immunomodulatory and protective effects on concanavalin a–induced hepatitis in mice (2000) (172)
- The bile acid sensor FXR regulates insulin transcription and secretion. (2010) (170)
- Antiatherosclerotic effect of farnesoid X receptor. (2009) (166)
- A Farnesoid X Receptor-Small Heterodimer Partner Regulatory Cascade Modulates Tissue Metalloproteinase Inhibitor-1 and Matrix Metalloprotease Expression in Hepatic Stellate Cells and Promotes Resolution of Liver Fibrosis (2005) (166)
- The Farnesoid X Receptor Promotes Adipocyte Differentiation and Regulates Adipose Cell Function in Vivo (2006) (164)
- Bile acid derivatives as ligands of the farnesoid X receptor. Synthesis, evaluation, and structure-activity relationship of a series of body and side chain modified analogues of chenodeoxycholic acid. (2004) (162)
- The Bile Acid Receptor GPBAR1 Regulates the M1/M2 Phenotype of Intestinal Macrophages and Activation of GPBAR1 Rescues Mice from Murine Colitis (2017) (160)
- PAR1 antagonism protects against experimental liver fibrosis. Role of proteinase receptors in stellate cell activation (2004) (160)
- A beta-oxidation-resistant lipoxin A4 analog treats hapten-induced colitis by attenuating inflammation and immune dysfunction. (2004) (157)
- Cross-Talk between Farnesoid-X-Receptor (FXR) and Peroxisome Proliferator-Activated Receptor γ Contributes to the Antifibrotic Activity of FXR Ligands in Rodent Models of Liver Cirrhosis (2005) (155)
- Role of tumor necrosis factor alpha release and leukocyte margination in indomethacin-induced gastric injury in rats. (1995) (152)
- 5-Amino-2-hydroxybenzoic Acid 4-(5-Thioxo-5H-[1,2]dithiol-3yl)-phenyl Ester (ATB-429), a Hydrogen Sulfide-Releasing Derivative of Mesalamine, Exerts Antinociceptive Effects in a Model of Postinflammatory Hypersensitivity (2006) (147)
- PPARs and other nuclear receptors in inflammation. (2006) (142)
- Cyclooxygenase-2-derived lipoxin A4 increases gastric resistance to aspirin-induced damage. (2002) (136)
- Potential cardioprotective actions of no-releasing aspirin (2002) (135)
- Interleukin 10 reduces lethality and hepatic injury induced by lipopolysaccharide in galactosamine-sensitized mice. (1996) (131)
- NCX-1000, a NO-releasing derivative of ursodeoxycholic acid, selectively delivers NO to the liver and protects against development of portal hypertension (2001) (130)
- Bile acid-activated receptors in the treatment of dyslipidemia and related disorders. (2010) (126)
- Interaction of a selective cyclooxygenase-2 inhibitor with aspirin and NO-releasing aspirin in the human gastric mucosa (2003) (121)
- The Bile Acid Sensor Farnesoid X Receptor Is a Modulator of Liver Immunity in a Rodent Model of Acute Hepatitis1 (2009) (121)
- NO-aspirin protects from T cell-mediated liver injury by inhibiting caspase-dependent processing of Th1-like cytokines. (2000) (110)
- Efficacy of the CCR5 Antagonist Maraviroc in Reducing Early, Ritonavir-Induced Atherogenesis and Advanced Plaque Progression in Mice (2013) (108)
- Importance of Innate Immunity and Collagen Binding Integrin α1β1 in TNBS-Induced Colitis (2002) (103)
- Enhanced anti-inflammatory effects of a nitric oxide-releasing derivative of mesalamine in rats. (1999) (102)
- Farnesoid X receptor: from structure to potential clinical applications. (2005) (101)
- IL-1β Converting Enzyme Is a Target for Nitric Oxide-Releasing Aspirin: New Insights in the Antiinflammatory Mechanism of Nitric Oxide-Releasing Nonsteroidal Antiinflammatory Drugs (2000) (101)
- Role of FXR in regulating bile acid homeostasis and relevance for human diseases. (2005) (97)
- NO‐naproxen modulates inflammation, nociception and downregulates T cell response in rat Freund's adjuvant arthritis (2000) (97)
- Probiotics VSL#3 Protect against Development of Visceral Pain in Murine Model of Irritable Bowel Syndrome (2013) (96)
- VSL#3 Resets Insulin Signaling and Protects against NASH and Atherosclerosis in a Model of Genetic Dyslipidemia and Intestinal Inflammation (2012) (93)
- An NO derivative of ursodeoxycholic acid protects against Fas-mediated liver injury by inhibiting caspase activity (2001) (93)
- A role for proteinase-activated receptor-1 in inflammatory bowel diseases. (2004) (92)
- NSAIDs, coxibs, CINOD and H2S-releasing NSAIDs: what lies beyond the horizon. (2007) (91)
- Counter-regulatory role of bile acid activated receptors in immunity and inflammation. (2010) (90)
- Inhibition of Intestinal Bacterial Translocation with Rifaximin Modulates Lamina propria Monocytic Cells Reactivity and Protects against Inflammation in a Rodent Model of Colitis (2003) (90)
- FXR an emerging therapeutic target for the treatment of atherosclerosis (2009) (88)
- BAR502, a dual FXR and GPBAR1 agonist, promotes browning of white adipose tissue and reverses liver steatosis and fibrosis (2017) (87)
- Inhibition of NF-κB by a PXR-dependent pathway mediates counter-regulatory activities of rifaximin on innate immunity in intestinal epithelial cells. (2011) (85)
- Probiotics Modulate Intestinal Expression of Nuclear Receptor and Provide Counter-Regulatory Signals to Inflammation-Driven Adipose Tissue Activation (2011) (81)
- Involvement of CD44 variant isoforms in hyaluronate adhesion by human activated T cells (1995) (80)
- The Bile Acid Sensor FXR Is Required for Immune-Regulatory Activities of TLR-9 in Intestinal Inflammation (2013) (80)
- Pregnane-X-receptor mediates the anti-inflammatory activities of rifaximin on detoxification pathways in intestinal epithelial cells. (2010) (79)
- The Methyl Transferase PRMT1 Functions as Co-Activator of Farnesoid X Receptor (FXR)/9-cis Retinoid X Receptor and Regulates Transcription of FXR Responsive Genes (2005) (78)
- The plant sterol guggulsterone attenuates inflammation and immune dysfunction in murine models of inflammatory bowel disease. (2009) (77)
- Mechanism of non-steroidal anti-inflammatory drug-gastropathy. (2001) (77)
- NCX-1000, a nitric oxide-releasing derivative of ursodeoxycholic acid, ameliorates portal hypertension and lowers norepinephrine-induced intrahepatic resistance in the isolated and perfused rat liver. (2003) (76)
- Disruption of an SP2/KLF6 Repression Complex by SHP Is Required for Farnesoid X Receptor-induced Endothelial Cell Migration* (2006) (73)
- Relative contribution of acetylated cyclooxygenase (COX)‐2 and 5‐lipooxygenase (LOX) in regulating gastric mucosal integrity and adaptation to aspirin (2003) (72)
- Farnesoid X receptor agonist for the treatment of liver and metabolic disorders: focus on 6-ethyl-CDCA. (2011) (71)
- Design, synthesis, and biological evaluation of potent dual agonists of nuclear and membrane bile acid receptors. (2014) (71)
- In vivo activated T cells in rheumatoid synovitis. Analysis of Th1‐ and Th2‐type cytokine production at clonal level in different stages of disease (2002) (69)
- Quantitative NMR-derived interproton distances combined with quantum mechanical calculations of 13C chemical shifts in the stereochemical determination of conicasterol F, a nuclear receptor ligand from Theonella swinhoei. (2012) (69)
- Nitric Oxide—Releasing NSAIDs (2001) (68)
- NCX-1015, a nitric-oxide derivative of prednisolone, enhances regulatory T cells in the lamina propria and protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice (2002) (67)
- Bile acids and their receptors in metabolic disorders. (2021) (67)
- Farnesoid X receptor suppresses constitutive androstane receptor activity at the multidrug resistance protein-4 promoter. (2011) (64)
- Exploitation of cholane scaffold for the discovery of potent and selective farnesoid X receptor (FXR) and G-protein coupled bile acid receptor 1 (GP-BAR1) ligands. (2014) (63)
- Proteinase‐activated Receptor‐1 is an Anti‐Inflammatory Signal for Colitis Mediated by a Type 2 Immune Response (2005) (62)
- Bile Acid Signaling in Inflammatory Bowel Diseases (2020) (62)
- Farnesoid X receptor modulators 2014-present: a patent review (2018) (62)
- A magic bullet for mucosal protection...and aspirin is the trigger! (2003) (61)
- Gastric acidity and gastroesophageal reflux patterns in patients with esophagitis. (1992) (60)
- The methionine connection: Homocysteine and hydrogen sulfide exert opposite effects on hepatic microcirculation in rats (2007) (60)
- Discovery of sulfated sterols from marine invertebrates as a new class of marine natural antagonists of farnesoid-X-receptor. (2011) (59)
- Metabolic Variability of a Multispecies Probiotic Preparation Impacts on the Anti-inflammatory Activity (2017) (58)
- 21‐NO‐prednisolone is a novel nitric oxide‐releasing derivative of prednisolone with enhanced anti‐inflammatory properties (2000) (58)
- Discovery That Theonellasterol a Marine Sponge Sterol Is a Highly Selective FXR Antagonist That Protects against Liver Injury in Cholestasis (2012) (58)
- Evidence that 5‐lipoxygenase and acetylated cyclooxygenase 2‐derived eicosanoids regulate leukocyte–endothelial adherence in response to aspirin (2003) (58)
- Theonellasterols and conicasterols from Theonella swinhoei. Novel marine natural ligands for human nuclear receptors. (2011) (56)
- Modification on ursodeoxycholic acid (UDCA) scaffold. discovery of bile acid derivatives as selective agonists of cell-surface G-protein coupled bile acid receptor 1 (GP-BAR1). (2014) (56)
- Development of non-antibiotic macrolide that corrects inflammation-driven immune dysfunction in models of inflammatory bowel diseases and arthritis. (2011) (56)
- Diabetic Mouse Angiopathy Is Linked to Progressive Sympathetic Receptor Deletion Coupled to an Enhanced Caveolin-1 Expression (2004) (55)
- Targetting farnesoid-X-receptor: from medicinal chemistry to disease treatment. (2010) (55)
- Mechanisms to prevent the toxicity of chronic neuroinflammation on forebrain cholinergic neurons. (2000) (54)
- Bile-acid-activated farnesoid X receptor regulates hydrogen sulfide production and hepatic microcirculation. (2009) (54)
- Glucocorticoid receptor mediates the gluconeogenic activity of the farnesoid X receptor in the fasting condition (2012) (53)
- Inhibition of Chronic Ulcerative Colitis-associated Adenocarcinoma Development in Mice by VSL#3 (2015) (52)
- The Pharmacology of Bile Acids and Their Receptors. (2019) (52)
- Primary brain abscess with Nocardia farcinica in an immunocompetent patient (2002) (52)
- NCX-4016 (NO-Aspirin) Inhibits Lipopolysaccharide-Induced Tissue Factor Expression In Vivo: Role of Nitric Oxide (2002) (52)
- Gastritis increases resistance to aspirin-induced mucosal injury via COX-2-mediated lipoxin synthesis. (2003) (52)
- Effect of acute and chronic levosulpiride administration on gastric tone and perception in functional dyspepsia (2002) (52)
- Importance of innate immunity and collagen binding integrin alpha1beta1 in TNBS-induced colitis. (2002) (51)
- Hijacking SARS-CoV-2/ACE2 Receptor Interaction by Natural and Semi-synthetic Steroidal Agents Acting on Functional Pockets on the Receptor Binding Domain (2020) (51)
- Reversal of Endothelial Dysfunction by GPBAR1 Agonism in Portal Hypertension Involves a AKT/FOXOA1 Dependent Regulation of H2S Generation and Endothelin-1 (2015) (50)
- Effect of erythromycin on gastric and gallbladder emptying and gastrointestinal symptoms in scleroderma patients is maintained medium term. (1994) (50)
- Role of PAR2 in pain and inflammation. (2002) (50)
- Farnesoid X receptor agonists in biliary tract disease (2009) (50)
- Mechanisms of nonsteroidal anti-inflammatory drug-induced gastrointestinal injury and repair: a window of opportunity for cyclooxygenase-inhibiting nitric oxide donors. (2004) (50)
- Obeticholic Acid: An Update of Its Pharmacological Activities in Liver Disorders. (2019) (49)
- CCR5 Antagonism by Maraviroc Reduces the Potential for Gastric Cancer Cell Dissemination. (2013) (49)
- The bile acid receptor GPBAR1 (TGR5) is expressed in human gastric cancers and promotes epithelial-mesenchymal transition in gastric cancer cell lines (2016) (48)
- Salicylates inhibit adhesion and transmigration of T lymphocytes by preventing integrin activation induced by contact with endothelial cells. (1998) (48)
- Aspirin-Triggered, Cyclooxygenase-2–Dependent Lipoxin Synthesis Modulates Vascular Tone (2004) (48)
- Dissociation of Intestinal and Hepatic Activities of FXR and LXRα Supports Metabolic Effects of Terminal Ileum Interposition in Rodents (2013) (48)
- Total synthesis and pharmacological characterization of solomonsterol A, a potent marine pregnane-X-receptor agonist endowed with anti-inflammatory activity. (2011) (48)
- Nitric oxide modulates proapoptotic and antiapoptotic properties of chemotherapy agents: the case of NO‐pegylated epirubicin (2006) (47)
- Effect of erythromycin administration on upper gastrointestinal motility in scleroderma patients. (1994) (47)
- Solomonsterols A and B from Theonella swinhoei. The first example of C-24 and C-23 sulfated sterols from a marine source endowed with a PXR agonistic activity. (2011) (47)
- NO-releasing NSAIDs are caspase inhibitors. (2001) (46)
- Binding mechanism of the farnesoid X receptor marine antagonist suvanine reveals a strategy to forestall drug modulation on nuclear receptors. Design, synthesis, and biological evaluation of novel ligands. (2013) (46)
- Future trends in the treatment of non‐alcoholic steatohepatitis (2018) (46)
- Reciprocal regulation of the bile acid-activated receptor FXR and the interferon-gamma-STAT-1 pathway in macrophages. (2009) (45)
- Cystathionine γ-lyase, a H2S-generating enzyme, is a GPBAR1-regulated gene and contributes to vasodilation caused by secondary bile acids. (2015) (44)
- Back door modulation of the farnesoid X receptor: design, synthesis, and biological evaluation of a series of side chain modified chenodeoxycholic acid derivatives. (2006) (44)
- Bile acid modulators for the treatment of nonalcoholic steatohepatitis (NASH) (2020) (44)
- Plakilactones from the marine sponge Plakinastrella mamillaris. Discovery of a new class of marine ligands of peroxisome proliferator-activated receptor γ. (2012) (44)
- Co-administration of nitric oxide-aspirin (NCX-4016) and aspirin prevents platelet and monocyte activation and protects against gastric damage induced by aspirin in humans. (2004) (43)
- Conicasterol E, a small heterodimer partner sparing farnesoid X receptor modulator endowed with a pregnane X receptor agonistic activity, from the marine sponge Theonella swinhoei. (2012) (43)
- Marine sponge steroids as nuclear receptor ligands. (2012) (43)
- Interactions Between Nuclear Receptor SHP and FOXA1 Maintain Oscillatory Homocysteine Homeostasis in Mice. (2015) (42)
- NO-aspirin: mechanism of action and gastrointestinal safety. (2003) (42)
- Polarization of the α6β4 integrin in ovarian carcinomas (1993) (42)
- Targeting FXR in cholestasis: hype or hope (2014) (42)
- Development of FXR, PXR and CAR agonists and antagonists for treatment of liver disorders. (2012) (41)
- Role of Nuclear Receptors in Lipid Dysfunction and Obesity-Related Diseases (2013) (41)
- Selective endoscopic retrograde cholangiography and preoperative bile duct stone removal in patients scheduled for laparoscopic cholecystectomy: a prospective study. (1996) (41)
- Circadian variations in gastric acid and pepsin secretion and intragastric bile acid in patients with reflux esophagitis and in healthy controls. (1995) (40)
- Impaired Itching Perception in Murine Models of Cholestasis Is Supported by Dysregulation of GPBAR1 Signaling (2015) (40)
- NCX‐4016, a nitric oxide‐releasing aspirin, protects endothelial cells against apoptosis by modulating mitochondrial function (2002) (40)
- Highly specific blockade of CCR5 inhibits leukocyte trafficking and reduces mucosal inflammation in murine colitis (2016) (40)
- Essential requirement for sphingosine kinase activity in eNOS‐dependent NO release and vasorelaxation (2006) (40)
- Hydrogen sulphide induces μ opioid receptor-dependent analgesia in a rodent model of visceral pain (2010) (40)
- A NO‐releasing derivative of acetaminophen spares the liver by acting at several checkpoints in the Fas pathway THIS ARTICLE HAS BEEN RETRACTED (2002) (39)
- Insights on FXR selective modulation. Speculation on bile acid chemical space in the discovery of potent and selective agonists (2016) (39)
- Farnesoid X receptor: from medicinal chemistry to clinical applications. (2012) (38)
- SHP-dependent and -independent induction of peroxisome proliferator-activated receptor-γ by the bile acid sensor farnesoid X receptor counter-regulates the pro-inflammatory phenotype of liver myofibroblasts (2011) (38)
- Aspirin, but not NO-releasing aspirin (NCX-4016), interacts with selective COX-2 inhibitors to aggravate gastric damage and inflammation (2004) (37)
- 4-Methylenesterols from Theonella swinhoei sponge are natural pregnane-X-receptor agonists and farnesoid-X-receptor antagonists that modulate innate immunity (2012) (37)
- Proteinase-Activated Receptor-2 Mediates Arterial Vasodilation in Diabetes (2005) (36)
- Anti-Very Late Antigen-1 Monoclonal Antibody Modulates the Development of Secondary Lesion and T-Cell Response in Experimental Arthritis (2000) (35)
- Cooperation between Aspirin-Triggered Lipoxin and Nitric Oxide (NO) Mediates Antiadhesive Properties of 2-(Acetyloxy)benzoic Acid 3-(Nitrooxymethyl)phenyl Ester (NCX-4016) (NO-Aspirin) on Neutrophil-Endothelial Cell Adherence (2004) (35)
- Gpbar1 agonism promotes a Pgc-1α-dependent browning of white adipose tissue and energy expenditure and reverses diet-induced steatohepatitis in mice (2017) (33)
- Oxygenated Polyketides from Plakinastrella mamillaris as a New Chemotype of PXR Agonists (2013) (33)
- Towards new ligands of nuclear receptors. Discovery of malaitasterol A, an unique bis-secosterol from marine sponge Theonella swinhoei. (2011) (32)
- Receptor-ligand interactions: Advanced biomedical applications. (2016) (32)
- NO-NSAIDs: from inflammatory mediators to clinical readouts. (2006) (32)
- Decoding the vasoregulatory activities of bile acid-activated receptors in systemic and portal circulation: role of gaseous mediators. (2017) (32)
- The Bile Acid Sensor FXR Protects against Dyslipidemia and Aortic Plaques Development Induced by the HIV Protease Inhibitor Ritonavir in Mice (2010) (31)
- Severe gastric mucosal damage induced by NSAIDs in healthy subjects is associated withHelicobacter pylori infection and high levels of serum pepsinogens (1995) (31)
- Activation of the farnesoid‐X receptor protects against gastrointestinal injury caused by non‐steroidal anti‐inflammatory drugs in mice (2011) (30)
- Nitric Oxide (NO)-Releasing Naproxen (HCT-3012 [(S)-6-Methoxy-α-methyl-2-naphthaleneacetic Acid 4-(Nitrooxy)butyl Ester]) Interactions with Aspirin in Gastric Mucosa of Arthritic Rats Reveal a Role for Aspirin-Triggered Lipoxin, Prostaglandins, and NO in Gastric Protection (2004) (30)
- COXIBs, CINODs and H₂S-releasing NSAIDs: current perspectives in the development of safer non steroidal anti-inflammatory drugs. (2011) (30)
- Agonism for the bile acid receptor GPBAR1 reverses liver and vascular damage in a mouse model of steatohepatitis (2018) (30)
- Steroidal scaffolds as FXR and GPBAR1 ligands: from chemistry to therapeutical application. (2015) (30)
- Liver delivery of NO by NCX‐1000 protects against acute liver failure and mitochondrial dysfunction induced by APAP in mice THIS ARTICLE HAS BEEN RETRACTED (2004) (29)
- Nitric Oxide Regulates Immune Cell Bioenergetic: A Mechanism to Understand Immunomodulatory Functions of Nitric Oxide-Releasing Anti-Inflammatory Drugs (2004) (29)
- NSAIDs upregulate β2‐integrin expression on human neutrophils through a calcium‐dependent pathway (1997) (29)
- FXR activation improves myocardial fatty acid metabolism in a rodent model of obesity-driven cardiotoxicity. (2013) (29)
- Nitric oxide modulates pepsinogen secretion induced by calcium-mediated agonist in guinea pig gastric chief cells. (1995) (28)
- Chenodeoxycholic Acid: An Update on Its Therapeutic Applications. (2019) (28)
- Hydrogen sulfide-based therapies: focus on H2S releasing NSAIDs. (2011) (28)
- Cardiac safety and antitumoral activity of a new nitric oxide derivative of pegylated epirubicin in mice (2007) (27)
- Ursodeoxycholic acid is a GPBAR1 agonist and resets liver/intestinal FXR signaling in a model of diet-induced dysbiosis and NASH. (2019) (27)
- Prevention of nonsteroidal anti-inflammatory drug-induced ulcer: looking to the future. (2009) (26)
- Aspirin, but not NO-releasing aspirin (NCX-4016), interacts with selective COX-2 inhibitors to aggravate gastric damage and inflammation. (2003) (26)
- BLOOD GLUCOSE TESTING AND FEDERAL REGULATIONS (1991) (26)
- GPBAR1 Functions as Gatekeeper for Liver NKT Cells and provides Counterregulatory Signals in Mouse Models of Immune-Mediated Hepatitis (2019) (25)
- Solomonsterol A, a Marine Pregnane-X-Receptor Agonist, Attenuates Inflammation and Immune Dysfunction in a Mouse Model of Arthritis (2013) (25)
- Bombesin-induced pancreatic regeneration in pigs is mediated by p46Shc/p52Shc and p42/p44 mitogen-activated protein kinase upregulation. (1998) (25)
- Polyhydroxylated sterols from the Indonesian soft coral Sinularia sp. and their effect on farnesoid X-activated receptor (2012) (25)
- Bile acid activated receptors are targets for regulation of integrity of gastrointestinal mucosa (2015) (25)
- Epidermal growth factor modulates pepsinogen secretion in guinea pig gastric chief cells. (1996) (25)
- Structure-based drug design targeting the cell membrane receptor GPBAR1: exploiting the bile acid scaffold towards selective agonism (2015) (25)
- Nitric oxide and portal hypertension: a nitric oxide-releasing derivative of ursodeoxycholic acid that selectively releases nitric oxide in the liver. (2003) (25)
- Endocrine activities and adipogenic effects of bisphenol AF and its main metabolite. (2019) (24)
- Novel Isoxazole Derivatives with Potent FXR Agonistic Activity Prevent Acetaminophen-Induced Liver Injury. (2018) (23)
- Bile acid-activated receptors and the regulation of macrophages function in metabolic disorders. (2020) (23)
- Targeting Bile Acid Receptors: Discovery of a Potent and Selective Farnesoid X Receptor Agonist as a New Lead in the Pharmacological Approach to Liver Diseases (2017) (23)
- Hyodeoxycholic acid derivatives as liver X receptor α and G-protein-coupled bile acid receptor agonists (2017) (23)
- The HIV Matrix Protein p17 Subverts Nuclear Receptors Expression and Induces a STAT1-Dependent Proinflammatory Phenotype in Monocytes (2012) (23)
- Divergent Effectiveness of Multispecies Probiotic Preparations on Intestinal Microbiota Structure Depends on Metabolic Properties (2019) (23)
- Effect of omeprazole on gastroesophageal reflux in Barrett's esophagus. (1989) (23)
- Treatment of portal hypertension with NCX-1000, a liver-specific NO donor. A review of its current status. (2006) (23)
- Different sensitivity of lamina propria T-cell subsets to nitric oxide-induced apoptosis explains immunomodulatory activity of a nitric oxide-releasing derivative of mesalamine in rodent colitis. (2005) (23)
- Unveiling hidden features of orphan nuclear receptors: the case of the small heterodimer partner (SHP). (2006) (23)
- Neurohumoral control of gallbladder motility in healthy subjects and diabetic patients with or without autonomic neuropathy (1990) (23)
- Erythromycin stimulates gallbladder emptying and motilin release by atropine-sensitive pathways (1992) (22)
- Effect of erythromycin on gallbladder emptying in diabetic patients with and without autonomic neuropathy and high levels of motilin (1992) (21)
- Treatment with all-trans retinoic acid plus tamoxifen and vitamin E in advanced hepatocellular carcinoma. (2004) (21)
- Farnesoid X receptor modulators (2011 – 2014): a patent review (2015) (21)
- PAR-2 modulates pepsinogen secretion from gastric-isolated chief cells. (2003) (21)
- NO-mesalamine protects colonic epithelial cells against apoptotic damage induced by proinflammatory cytokines. (2001) (21)
- Disruption of TFG&bgr;‐SMAD3 pathway by the nuclear receptor SHP mediates the antifibrotic activities of BAR704, a novel highly selective FXR ligand (2018) (21)
- The Aryl Hydrocarbon Receptor (AhR) Mediates the Counter-Regulatory Effects of Pelargonidins in Models of Inflammation and Metabolic Dysfunctions (2019) (21)
- Leukotrienes stimulate pepsinogen secretion from guinea pig gastric chief cells by a nitric oxide-dependent pathway. (1995) (21)
- Salicylates Inhibit T Cell Adhesion on Endothelium Under Nonstatic Conditions: Induction of L-Selectin Shedding by a Tyrosine Kinase-Dependent Mechanism (2001) (21)
- Investigation around the Oxadiazole Core in the Discovery of a New Chemotype of Potent and Selective FXR Antagonists. (2019) (21)
- Ritonavir-Induced Lipoatrophy and Dyslipidaemia is Reversed by the Anti-Inflammatory Drug Leflunomide in a Ppar-Γ-Dependent Manner (2012) (20)
- Hijacking SARS-Cov-2/ACE2 receptor interaction by natural and semi-synthetic steroidal agents acting on functional pockets on receptor binding region (2020) (20)
- Isolated guinea pig gastric chief cells express tumour necrosis factor receptors coupled with the sphingomyelin pathway. (1996) (20)
- Bile Acids Activated Receptors in Inflammatory Bowel Disease (2021) (20)
- Gynecomastia during omeprazole therapy. (1991) (20)
- Enhanced Anti-Inflammatory Potency of a Nitric Oxide-Releasing Derivative of Flunisolide: Role of Nuclear Factor-κB (2004) (20)
- The nuclear receptor FXR regulates hepatic transport and metabolism of glutamine and glutamate. (2011) (19)
- Functional and clinical relevance of CD44 variant isoform expression on B-cell chronic lymphocytic leukemia cells. (1998) (19)
- Modification in the side chain of solomonsterol A: discovery of cholestan disulfate as a potent pregnane-X-receptor agonist. (2012) (19)
- Opposite effects of the FXR agonist obeticholic acid on Mafg and Nrf2 mediate the development of acute liver injury in rodent models of cholestasis. (2020) (19)
- Cyclo-oxygenase isoenzymes. Structural basis for selective inhibition of cyclo-oxygenases by anti-inflammatory agents. (2001) (19)
- Pathogenesis of non-steroidal anti-inflammatory drug gastropathy. (1999) (19)
- HIV-1 infection is associated with changes in nuclear receptor transcriptome, pro-inflammatory and lipid profile of monocytes (2012) (18)
- Mechanistic role of p38 MAPK in gastric cancer dissemination in a rodent model peritoneal metastasis. (2012) (18)
- A role for proteinase-activated receptor-1 in inflammatory bowel diseases. (2004) (18)
- Molecular decodification of gymnemic acids from Gymnema sylvestre. Discovery of a new class of liver X receptor antagonists (2015) (18)
- Phallusiasterols A and B: Two New Sulfated Sterols from the Mediterranean Tunicate Phallusia fumigata and Their Effects as Modulators of the PXR Receptor (2014) (17)
- Bazedoxifene-scaffold-based mimetics of solomonsterols A and B as novel pregnane X receptor antagonists. (2014) (17)
- FENSAP-ICE Applications to Unmanned Aerial Vehicles (UAV) (2004) (17)
- Preliminary Structure-Activity Relationship on Theonellasterol, a New Chemotype of FXR Antagonist, from the Marine Sponge Theonella swinhoei (2012) (17)
- Helicobacter pylori and non-steroidal anti-inflammatory drugs. (2000) (17)
- Polarization of the alpha 6 beta 4 integrin in ovarian carcinomas. (1993) (17)
- Activation of the bile acid receptor GPBAR1 protects against gastrointestinal injury caused by non‐steroidal anti‐inflammatory drugs and aspirin in mice (2013) (17)
- Farnesoid X Receptor: From Structure to Potential Clinical Applications (2005) (17)
- The Bile Acid Receptor GPBAR1 Modulates CCL2/CCR2 Signaling at the Liver Sinusoidal/Macrophage Interface and Reverses Acetaminophen-Induced Liver Toxicity (2020) (16)
- The First Total Synthesis of Solomonsterol B, a Marine Pregnane X Receptor Agonist (2012) (16)
- Transcriptome Analysis of Dual FXR and GPBAR1 Agonism in Rodent Model of NASH Reveals Modulation of Lipid Droplets Formation (2019) (15)
- Gene expression changes induced by HIPEC in a murine model of gastric cancer. (2012) (15)
- Epigenetic Modulation by Methionine Deficiency Attenuates the Potential for Gastric Cancer Cell Dissemination (2012) (15)
- Inhibition of NF-kB by a PXR-Dependent Pathway Mediates Counter-regulatory Activities of Rifaximin on Innate Immunity in Intestinal Epithelial Cells (2011) (15)
- Lipoxins in gastric mucosal health & disease (2005) (15)
- Type III procollagen peptide and PZ-peptidase serum levels in pre-cirrhotic liver diseases. (1985) (14)
- Oesophageal lesions during treatment with piroxicam. (1990) (14)
- Insights on pregnane-X-receptor modulation. Natural and semisynthetic steroids from Theonella marine sponges. (2014) (14)
- Investigation on bile acid receptor regulators. Discovery of cholanoic acid derivatives with dual G-protein coupled bile acid receptor 1 (GPBAR1) antagonistic and farnesoid X receptor (FXR) modulatory activity (2016) (14)
- Structural insights into Estrogen Related Receptor-β modulation: 4-Methylenesterols from Theonella swinhoei sponge as the first example of marine natural antagonists (2014) (14)
- FXR mediates a chromatin looping in the GR promoter thus promoting the resolution of colitis in rodents. (2013) (14)
- A nitro-arginine derivative of trimebutine (NO2-Arg-Trim) attenuates pain induced by colorectal distension in conscious rats. (2009) (14)
- Navigation in bile acid chemical space: discovery of novel FXR and GPBAR1 ligands (2016) (13)
- Effect of NSAIDs on pepsinogen secretion and calcium mobilization in isolated chief cells. (1995) (13)
- Synthesis and characterization of well-defined poly(2-deoxy-2-methacrylamido-d-glucose) and its biopotential block copolymers via RAFT and ROP polymerization (2018) (13)
- Discovery of ((1,2,4-oxadiazol-5-yl)pyrrolidin-3-yl)ureidyl derivatives as selective non-steroidal agonists of the G-protein coupled bile acid receptor-1 (2019) (13)
- Isoswinholide B and swinholide K, potently cytotoxic dimeric macrolides from Theonella swinhoei. (2013) (13)
- Serum Bile Acid Levels Before and After Sleeve Gastrectomy and Their Correlation with Obesity-Related Comorbidities (2019) (13)
- Effect of omeprazole and high doses of ranitidine on gastric acidity and gastroesophageal reflux in patients with moderate-severe esophagitis. (1990) (13)
- Motilin and erythromycin stimulate pepsinogen secretion by chief cells isolated from guinea pig stomach. (1993) (12)
- New brominated flame retardants and their metabolites as activators of the pregnane X receptor. (2016) (12)
- Gastrin-releasing peptide directly releases pepsinogen from guinea pig chief cells. (1990) (12)
- Abscess formation in hepatocellular carcinoma: Complications of percutaneous ultrasound‐guided ethanol injection (1993) (12)
- Marine and Semi-Synthetic Hydroxysteroids as New Scaffolds for Pregnane X Receptor Modulation (2014) (12)
- Discovery of a AHR pelargonidin agonist that counter-regulates Ace2 expression and attenuates ACE2-SARS-CoV-2 interaction (2021) (12)
- Genetic and Pharmacological Dissection of the Role of Spleen Tyrosine Kinase (Syk) in Intestinal Inflammation and Immune Dysfunction in Inflammatory Bowel Diseases. (2017) (11)
- Targeting the transsulfuration-H2S pathway by FXR and GPBAR1 ligands in the treatment of portal hypertension. (2016) (11)
- Anti‐Inflammatory Activity of a New Class of Nitric Oxide Synthase Inhibitors That Release Nitric Oxide (2008) (11)
- l-Arginine/nitric oxide pathway modulates gastric motility and gallbladder emptying induced by erythromycin and liquid meal in humans (1995) (11)
- Placebo-controlled comparison of piroxicam-β-cyclodextrin, piroxicam, and indomethacin on gastric potential difference and mucosal injury in humans (1992) (11)
- Chalinulasterol, a Chlorinated Steroid Disulfate from the Caribbean Sponge Chalinula molitba. Evaluation of Its Role as PXR Receptor Modulator (2012) (11)
- Incisterols, highly degraded marine sterols, are a new chemotype of PXR agonists (2014) (11)
- Nanotraps with biomimetic surface as decoys for chemokines. (2017) (11)
- Linking liver metabolic and vascular disease via bile acid signaling. (2021) (10)
- Lipoxins in gastric mucosal health and disease. (2005) (10)
- The HIV Matrix Protein p17 Promotes the Activation of Human Hepatic Stellate Cells through Interactions with CXCR2 and Syndecan-2 (2014) (10)
- Decoding the role of the nuclear receptor SHP in regulating hepatic stellate cells and liver fibrogenesis (2017) (10)
- Hydrogen sulfide: from physiology to pharmacology. (2011) (10)
- The identification of farnesoid X receptor modulators as treatment options for nonalcoholic fatty liver disease (2021) (10)
- The bile acid activated receptors GPBAR1 and FXR exert antagonistic effects on autophagy (2020) (10)
- Gastric and esophageal acidity during continuous treatment with H2-antagonists in uncomplicated esophagitis. (1989) (9)
- New tridecapeptides of the theonellapeptolide family from the Indonesian sponge Theonella swinhoei (2013) (9)
- 5-Hydroxytryptamine 3-receptor antagonist modulates gallbladder emptying and motilin release induced by erythromycin (1993) (9)
- Heat shock proteins as key biological targets of the marine natural cyclopeptide perthamide C. (2012) (9)
- Analysis of Gastric Cancer Transcriptome Allows the Identification of Histotype Specific Molecular Signatures With Prognostic Potential (2021) (9)
- Duodenal osmolality drives gallbladder emptying in humans (1990) (9)
- Amphiphilic polypeptides with prolonged enzymatic stability for the preparation of self-assembled nanobiomaterials (2018) (9)
- Intragastric pH monitoring during antisecretory therapy in patient with gastrointestinal bleeding. (1989) (9)
- PATHOGENESIS OF NSAID GASTROPATHY (1999) (9)
- Gastric Tolerance of Piroxicam-β-Cyclodextrin Compared with Placebo and with Other NSAIDs (1990) (9)
- Bile acid activated receptors: Integrating immune and metabolic regulation in non-alcoholic fatty liver disease (2021) (8)
- Do anticholinergics interact with histamine H2 receptor antagonists on night intragastric acidity in active duodenal ulcer patients? (1988) (7)
- Control of gastric pH with ranitidine in critically Ill patients (1991) (7)
- Proteinase‐activated receptors (PARs) and immune function (2003) (7)
- Immunomodulatory functions of FXR (2022) (7)
- The HIV matrix protein p17 induces hepatic lipid accumulation via modulation of nuclear receptor transcriptoma (2015) (7)
- Atorvastatin protects against liver and vascular damage in a model of diet induced steatohepatitis by resetting FXR and GPBAR1 signaling (2021) (7)
- Dual COX-inhibitors: the answer is NO? (2005) (6)
- Celecoxib exacerbates gastrointestinal damage induced by aspirin but not by no-aspirin (NCX-4016): A randomised, parallel group, blind-observer endoscopic study. Evidence for a protective role of no in the gastrointestinal mucosa (2003) (6)
- Discovery of Bile Acid Derivatives as Potent ACE2 Activators by Virtual Screening and Essential Dynamics (2021) (6)
- Special FX: Harnessing the Farnesoid-X-Receptor to Control Bile Acid Synthesis (2021) (6)
- Effect of HCT1026, a nitric oxide (NO) releasing derivative of flurbiprofen on gastrointestinal mucosa: a double blind placebo-controlled endoscopic study (2003) (5)
- GPBAR1 Activation by C6-Substituted Hyodeoxycholane Analogues Protect against Colitis. (2020) (5)
- Discovery of a Novel Multi-Strains Probiotic Formulation with Improved Efficacy toward Intestinal Inflammation (2020) (5)
- Phallusiasterol C, A New Disulfated Steroid from the Mediterranean Tunicate Phallusia fumigata (2016) (5)
- Prostaglandin E2 desensitizes cAMP-mediated pepsinogen secretion in chief cells. (1991) (5)
- Anti-atherosclerotic effect of Farnesoid-X-Receptor in ApoE -/- mice (2008) (4)
- Identification of Cysteinyl-leukotriene-receptor 1 antagonists as ligands for the bile acid receptor GPBAR1. (2020) (4)
- Tumor necrosis factor α receptor-antagonists protect against indomethacin-induced gastric mucosal injury in rats (1995) (4)
- Erratum (Retracted article): A role for proteinase-activated receptor-1 in inflammatory bowel diseases (Journal of Clinical Investigation (2004) 114 (1444-1456) DOI:10.1172/JCI200421689) (2006) (4)
- 3α-6α-Dihydroxy-7α-fluoro-5β-cholanoate (UPF-680), physicochemical and physiological properties of a new fluorinated bile acid that prevents 17α-ethynyl-estradiol-induced cholestasis in rats (2006) (4)
- Diethylstilbestrol-scaffold-based pregnane X receptor modulators. (2015) (4)
- Epoxide functionalization on cholane side chains in the identification of G-protein coupled bile acid receptor (GPBAR1) selective agonists (2017) (4)
- Mechanistic Role of p38 MAPK in Gastric Cancer Dissemination in a Rodent Model Peritoneal Metastasis (2011) (3)
- GLP-1 Mediates Regulation of Colonic ACE2 Expression by the Bile Acid Receptor GPBAR1 in Inflammation (2022) (3)
- Beneficial effects of UDCA and norUDCA in a rodent model of steatosis are linked to modulation of GPBAR1/FXR signaling. (2022) (3)
- Next-Generation Sequencing Analysis of Gastric Cancer Identifies the Leukemia Inhibitory Factor Receptor as a Driving Factor in Gastric Cancer Progression and as a Predictor of Poor Prognosis (2022) (3)
- Introduction of Nonacidic Side Chains on 6-Ethylcholane Scaffolds in the Identification of Potent Bile Acid Receptor Agonists with Improved Pharmacokinetic Properties (2019) (3)
- FXR Promotes Adipocyte Differentiation and regulates adipose cell function in vivo (2006) (3)
- In vivo administration of ritonavir worsens intestinal damage caused by cyclooxygease inhibitors. (2014) (3)
- Su1053 - Bar704, a Potent and Selective Fxr Agonist Protects Against Intestinal Fibrosis (2018) (2)
- 3alpha-6alpha-Dihydroxy-7alpha-fluoro-5beta-cholanoate (UPF-680), physicochemical and physiological properties of a new fluorinated bile acid that prevents 17alpha-ethynyl-estradiol-induced cholestasis in rats. (2006) (2)
- A new protective mechanisn in NSAID gastropathy. Evidence that hydrogen sulfide (H2S) modulates gastric mucosal integrity (2005) (2)
- Immunephenotype Predicts Response to Vedolizumab: Integrating Clinical and Biochemical Biomarkers in the Treatment of Inflammatory Bowel Diseases (2018) (2)
- Repositioning Mifepristone as a Leukaemia Inhibitory Factor Receptor Antagonist for the Treatment of Pancreatic Adenocarcinoma (2022) (2)
- Estimation of the Mechanical Parameters for a Reduced Coupled Flexural–Torsional Beam Model of a Tall Building by a Sub-Structure Approach (2021) (2)
- M1735 FXR Activation Reverses Insulin Resistance and Protects Against NASH Development (2009) (2)
- SNK @ DANKMEMES: Leveraging Pretrained Embeddings for Multimodal Meme Detection (short paper) (2020) (2)
- Prevention of gastric damage by no-releasing aspirin (NCX-4016) is mediated by inhibition of ICE/-like proteases in gastric mucosa and endothelial cells (1998) (2)
- Bile acid metabolism and bile acid receptor signaling in metabolic diseases and therapy (2021) (2)
- Cephalic stimulation of gallbladder motility: effects of opioid receptor antagonist naloxone (1988) (2)
- Correction: The Bile Acid Receptor GPBAR-1 (TGR5) Modulates Integrity of Intestinal Barrier and Immune Response to Experimental Colitis (2013) (2)
- Sa1959 Instruction of Intestinal Microbiota by VSL#3 Protects Against NSAIDs-PPI Enteropathy (2013) (1)
- Tu1111: REGULATION OF INTESTINAL ACE2 EXPRESSION BY THE BILE ACID RECEPTOR GPBAR1 IS MEDIATED BY A GPBAR1/GLP-1/GLP-1R AXIS (2022) (1)
- Organoids as ex vivo culture system to investigate infection-host interaction in gastric pre-carcinogenesis. (2022) (1)
- [Healing of esophageal ulcer after treatment with omeprazole in a patient with scleroderma and Barrett's esophagus]. (1988) (1)
- GPBAR1 (TGR5) Ligation Protects Against Colitis Development by Regulating Leukocyte Traffinking and Promoting a IL-10 Dependent Shift in the M1/M2 Phenotype (2017) (1)
- Inverse Virtual Screening for the rapid re-evaluation of the presumed biological safe profile of natural products. The case of steviol from Stevia rebaudiana glycosides on farnesoid X receptor (FXR). (2021) (1)
- Editorial [Hot Topic: Nitric Oxide and Lipoxins: Role in Inflammation and Defence (Guest Editor: Stefano Fiorucci)] (2006) (1)
- The FXR-agonist, 6-ethyl-chenodeoxycholic acid (6-ECDCA), protects against estrogen-induced cholestasis in rats (2003) (1)
- Discovery of a Potent and Orally Active Dual GPBAR1/CysLT1R Modulator for the Treatment of Metabolic Fatty Liver Disease (2022) (1)
- NO-NSAID gastrointestinal safety is related to inhibition of ICE-like Cysteine Proteases. New insights into the moleculare basis of NSAID gastropathy (1998) (1)
- Biodegradability of inhaled organic particles in patients with chronic bronchitis. (1987) (1)
- [Diagnostic effectiveness of immunoreactive serum trypsinogen, pancreatic iso-amylase and lipase in the diagnosis of acute pancreatic injury in hyperamylasemic patients]. (1986) (1)
- Essential Role of DNAX Adaptor Protein 12 (DAP12) and Spleen Tyrosine Kinase (Syk) in Inflammation-Driven Immune Dysfunction in Rodent Model of Colitis. (2011) (1)
- Editorial [Hot Topic :Current Advances In Therapeutic Applications of Nuclear Receptors (Guest Editor: Stefano Fiorucci)] (2012) (1)
- 773 The Bile Acid Sensor FXR Modulates Hydrogen Sulfide Generation in the Gastric Mucosa and Protects Against Injury Caused by Aspirin (2010) (1)
- Structural Basis for Developing Multitarget Compounds Acting on Cysteinyl Leukotriene Receptor 1 and G-Protein-Coupled Bile Acid Receptor 1. (2021) (1)
- M1739 Ml3403, a New p38 MAPK Inhibitor, Corrects Immune Dysfunction in Rodent Models of Chronic Inflammatory Disorders (2010) (1)
- M1802 Rifaximin is a Human Pregnane X Receptor Activator in Human Colon Epithelial Cells and Regulate Detoxification Pathway (2010) (1)
- the Bile Acid Sensor FXR Induces the Glucocorticoid Receptor in the Liver in a Promoter-Dependent Manner (2011) (1)
- Current advances in therapeutic applications of nuclear receptors. (2012) (1)
- Variability in Industrial Production Affects Probiotics Activity: Identification of Batches of Probiotic VSL#3 that Increases Intestinal Permeability and Worsens Colitis in Rodents (2017) (1)
- TRPM8 indicates poor prognosis in colorectal cancer patients and its pharmacological targeting reduces tumour growth in mice by inhibiting Wnt/β‐catenin signalling (2022) (1)
- ATB-429 , a hydrogen sulfide-releasing derivative of mesalamine , exerts anti-nociceptive effects in a model of post-inflammatory hypersensitivity (2006) (1)
- Hyperglycemia Decreases the Erythromycin-induced Gallbladder Emptying and Motilin Release In Normal Subjects (1994) (0)
- A novel, hydrogen sulfide-releasing mesalamine derivative (ATB-429) exhibits enhanced anti-inflammatory and analgesic activity in experimental colitis: O-0010 (2007) (0)
- IL-1 b Converting Enzyme Is a Target for Nitric Oxide-Releasing Aspirin: New Insights in the Antiinflammatory Mechanism of Nitric Oxide-Releasing Nonsteroidal Antiinflammatory Drugs (2000) (0)
- NO-Aspirin (NCX-4016) prevents platelet and monocyte activation inducing less gastric damage compared to aspirin (2004) (0)
- Role of mRAGEs and ACE2 in SARS-CoV-2-Related Inflammation. (2022) (0)
- Nitric oxide-derived NSAIDs inhibit ICE-like cysteine proteases, IL-1 beta and IFN gamma release and protect from Concanavallin A-induced acute liver injury. (1998) (0)
- Bombesin (BB) stimulates angiogenesis in large mammalian pancreas and MAPK activity and proliferation on endothelial cells (1998) (0)
- Effect of bombesin on pancreatic regeneration after subtotal distal pancreasectomy. (1997) (0)
- Tu2051 The HIV Matrix Protein P17 Subverts the Nuclear Receptor Transcriptome in HEPG2 Cells (2013) (0)
- Treatment strategy of hepatocellular carcinoma: Comparison between percutaneous ethanol injection and radiofrequency ablation, a three-year follow-up study (2003) (0)
- RNAseq analysis HFD mice (2019) (0)
- BAR130, a Hyodeoxycholic Acid Derivative as the First Example of Dual LXRα/GPBAR1 Agonist (2017) (0)
- The crosstalk between gut barrier impairment, mitochondrial dysfunction, and microbiota alterations in people living with HIV (2022) (0)
- NO-NSAIDs are ICE/caspase1 inhibitors and protect from citokine-mediated acute liver failure induced by Concanavalin A in mice. (1999) (0)
- Sa1587 A Comprehensive Analysis of Small Heterodimer Partner (SHP) Target Genes in Hepatic Stellate Cells and the Discovery of a New Class of SHP Agonists That Reduces Liver Fibrosis (2016) (0)
- Expanding the Library of 1,2,4-Oxadiazole Derivatives: Discovery of New Farnesoid X Receptor (FXR) Antagonists/Pregnane X Receptor (PXR) Agonists (2023) (0)
- Marine natural products as modulators of nuclear receptors (2012) (0)
- Activation of FXR Improves Myocardial Fatty Acid Metabolism in a Rodent Model of Liver Steatosis (2011) (0)
- EGF modulates pepsinogen secretion by activating multiple intracellular pathway in gastric isolated chief cells. (1996) (0)
- Discovery of BAR502, as potent steroidal antagonist of leukemia inhibitory factor receptor for the treatment of pancreatic adenocarcinoma (2023) (0)
- Modulation of the nuclear receptor for farnesoidi (fxr) with agonists molecules for the prevention and treatment of atherosclerotic phenomena induced by administration of protease inhibitors (2010) (0)
- Transcriptomic analysis of a mouse model of Acetaminophen-induced hepatitis (2019) (0)
- Mo1353: DEVELOPMENT OF A DUAL GPBAR1 AND CYSTLTR1 MODULATOR TO PREVENT HEPATIC DAMAGE AND LIVER FIBROSIS (2022) (0)
- Molecular Determinants of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in a Model of Peritoneal Gastric Cancer Carcinogenesis (2011) (0)
- Effect of NO donors and NO-aspirin on TNF release and gastric mucosal damage in rats and isolated macrophages (1997) (0)
- GDF15 in Vascular and Liver Metabolic Disorders: A Novel Therapeutic Target. (2022) (0)
- Discovery of Bar704, A Potent and Selective FXR Agonist, that Protects Against Liver Fibrosis (2017) (0)
- Metagenomic analysis in a mouse model of steatohepatitis (2019) (0)
- Bile acid derivatives as FXR ligands for the prevention or treatment of diseases or conditions mediated by FXR (2007) (0)
- Tu2041 Instruction of Intestinal Microbiota by VSL#3 Reverses NASH and Accelerated Atherosclerosis Caused by Intestinal Inflammation in ApoE-/- Mice (2012) (0)
- Bombesin-induced pancreatic regeneration in rats is age-dependent (1998) (0)
- Galectin-1 protects against concanavalin a-induced liver injury by preventing T cell activation. (1999) (0)
- Notice of Retraction: ‘A NO‐releasing derivative of acetaminophen spares the liver by acting at several checkpoints in the Fas pathway’ (Br J Pharmacol 135; 589–599; 2002) (2009) (0)
- Development of Effective and Safe Analgesic and Anti-Inflammatory Drugs: Harnessing Natural Substances for Clinical Solutions. (2021) (0)
- Mo2014 – Comparative Effects of Bar502, a Dual Fxr and Gpbar1 Agonist, Obeticholic Acid and Ursodeoxycholic Acid in a Rodent Model of Nash (2019) (0)
- Tu1738 - The Aryl Hydrocarbon Receptor Mediates Anti-Inflammatory Activities of Natural and Synthetic Pelargonidines in Mouse Models of Colitis (2018) (0)
- 1009 Epigenetic Modulation of Adhesion and Proliferation Pathways by Methionine Deficiency Attenuates Potential for Dissemination of Gastric Cancer Cells (2012) (0)
- Tu1417 Modification of Intestinal Microbiota by VSL#3 Protects Against Development of Pain in the Neonatal Maternal Separation Model. a Whole Genome Array Investigation (2012) (0)
- Coupled to an Enhanced Caveolin-1 Expression Diabetic Mouse Angiopathy Is Linked to Progressive Sympathetic Receptor Deletion (2004) (0)
- Su1733 The Bile Acid Receptor TGR5 Maintains Gastrointestinal Homeostasis and Its Activation Rescues From Gastrointestinal Injury Caused by ASA and NSAIDs (2012) (0)
- 4 P Dual cyclo-lipo-oxygenase inhibition spares the gastric mucosa in aspirin treated rats (2002) (0)
- Procede de reduction d'effets secondaires indesirables induits par un medicament chez un patient (2005) (0)
- T1965 Bile Acids Induce Rat PPARγ2 Gene via Activation of Farnesoid X Receptor. (2010) (0)
- How smell regulates metabolism: The role of ectopically expressed olfactory receptors in lipid and glucose homeostasis (2022) (0)
- Oxide-Releasing Anti-Inflammatory Drugs Immunomodulatory Functions of Nitric Bioenergetic: A Mechanism to Understand Nitric Oxide Regulates Immune Cell (2004) (0)
- 2 - GPBAR1 (TGR5) Agonism Reverses Endothelial Dysfunction and Liver Injury in a Dietetic Model of Steatohepatitis (2018) (0)
- Preventing Integrin Activation Induced by Contact With Endothelial Cells Salicylates Inhibit Adhesion and Transmigration of T Lymphocytes by (2013) (0)
- Discovery of a AhR flavonoid agonist that counter-regulates ACE2 expression in rodent models of inflammation and attenuates ACE2-SARS-CoV2 interaction in vitro (2021) (0)
- Mo1915 Genetic Ablation and Pharmacological Blockade of CCR5 by the anti-HIV Small Molecule Inhibitor Maraviroc Inhibits Leukocyte Trafficking and Protects Against Mucosal Inflammation in Murine Models Colitis (2016) (0)
- Proteinase activated receptor (PAR)-2 protects against colitis in mice. Evidence for direct modulation of lamina propria T lymphocytes (2001) (0)
- The CCR5 antagonist maraviroc reduces the potential for gastric cancer dissemination in rodent models (2013) (0)
- 16 A Dark Side of FXR Activation in Cholestasis. FXR Is a Negative Regulator of MRP4 (2009) (0)
- Molecular Docking and Dynamics Simulation Studies of a Dataset of NLRP3 In-flammasome Inhibitors (2022) (0)
- Penthoxyfilline Protects Against Indomethacin-induced Acute Gastric-mucosal Damage In Rats (1993) (0)
- Stimulation of small intestine chemoreceptors activates rectal afferent pathways in IBS patients (2000) (0)
- Tu1748 - Probiotics Beyond Taxonomy: Evidence that Anti-inflammatory Properties of Live Biotherapeutic Products Require Phenotypic Characterization (2018) (0)
- The methyl trasnferase PRMT1 functions as coactivator of FXR/RXR and regulates transcription of FXR responsive genein hepatocytes (2004) (0)
- Tu1828 GPBAR1(TGR5) Is Highly Expressed in Human Gastric Cancers and Its Activation by Selective or GPBAR1/FXR Dual Ligands Promotes Epithelial Mesenchymal Transition and Tumor Spreading (2016) (0)
- Aroleforproteinase-activatedreceptor-1ininflammatoryboweldiseases (2006) (0)
- Tu1920 a Farnesoid-X-Receptor (FXR)-Glucocorticoid Receptor (GR) Cascade Regulates Intestinal Innate Immunity in Response to FXR Activation (2012) (0)
- 8 OP Rifaximin protects against colitis development by reducing local immuneu response to bacterial antigen (2002) (0)
- Discovery of a Novel Class of Dual GPBAR1 Agonists–RORγt Inverse Agonists for the Treatment of IL-17-Mediated Disorders (2023) (0)
- of Intestinal Innate Immunity The Bile Acid Receptor FXR Is a Modulator (2009) (0)
- 1079 Macrolide Derivatives Devoid of Antibiotic Activity Correct Immune Dysfunction in Rodent Models of Inflammatory Bowel Diseases. (2010) (0)
- Safety and Anti-Inflammatory Effects of a Hydrogen ulfide – Releasing Diclofenac Derivative in the Rat (0)
- Co-administration of NO-Aspirin (NCX-4016) and Aspirin prevents platelet and monocyte activation and protects against damage induced by aspirin in humans. (2004) (0)
- Type two of proteinase activated receptors (PAR-2) protects against colitis through a CGRP-dependent pathway (2000) (0)
- Combinatorial targeting of GPBAR1 and CYSLTR1 reveals a mechanistic role for bile acids and leukotrienes in drug induced liver injury. (2022) (0)
- Eleventh International Congress on Drug Therapy in HIV Infection (2012) (0)
- 825 BAR502, a Dual FXR and GPBAR1 Agonist, Reverses Steatosis and Fibrosis in Rodent Model of NASH By Modulating Authophagic Genes (2016) (0)
- BAR501, A Selective Gpbar1 Agonist, Promotes Adipose Tissue Browning and Autophagy and Improves Lipid Metabolism and Steato-Hepatitis in Mice Feed a High Fat Diet (2017) (0)
- Tu2023 A Novel Source of Intestinal Damage: The HIV Protease Inhibitor Ritonavir Worsens Damage Caused by COX Inhibitors. (2013) (0)
- [Pharmacologic effect of a new synthetic analog of somatostatin (SMS 201-995) on fasting intragastric pH in subjects with duodenal ulcer]. (1988) (0)
- Tu1546 – Gpbar1 is a Modulator of Liver Immunity and Its Agonism Reverses Acetaminophen-Induced Hepatotoxicity by Modulating Recruitment of Liver Macrophages (2019) (0)
- Modeling inflammatory bowel disease by intestinal organoids. (2022) (0)
- Transcriptomic analysis of Human gastric cancer (2020) (0)
- A Hydrogen‐Sulfide Releasing Derivative of Mesalamine Exhibits Markedly Enhanced Anti‐Inflammatory Effects in Experimental Colitis (2007) (0)
- [Nonsurgical treatment of hemorrhage caused by esophageal varices]. (1988) (0)
- Discovery of ((1,2,4-oxadiazol-5-yl)pyrrolidin-3-yl)ureidyl derivatives as selective non-steroidal agonists of the G-protein coupled bile acid receptor-1 (2019) (0)
- 1108 Reciprocal Regulation of TLRS and Nuclear Receptors: IRF-7 Dependent Regulation of FXR Mediates Counter-Regulatory Effects of TLR-9 in Colitis (2012) (0)
- NCX-1000: a liver-specific NO donor (2004) (0)
- 604 H2S Induces Analgesia Is Mediated In Vivo Activation of μ Opioid Receptor and PI3K/AKT Pathway Activation (2009) (0)
- Farnesoid-X-receptor (FXR) ligands induce a small heterodimer partner (SHP)-dependent upregulation of PPAR-gamma in hepatic stellate cells and in rat model of liver fibrosis. (2004) (0)
- Sa1541: DISCOVERY OF A NOVEL CYSTEINYL-LEUKOTRIENE-RECEPTOR 1 ANTAGONIST AND BILE ACID RECEPTOR GPBAR1 AGONIST THAT REDUCES INFLAMMATION IN A MOUSE MODEL OF COLITIS (2022) (0)
- Bisphenol AF: Does bisphenol AF glucuronide have endocrine activity? (2017) (0)
- Model of Acute Hepatitis a Modulator of Liver Immunity in a Rodent The Bile Acid Sensor Farnesoid X Receptor Is (2009) (0)
- Su2132 Dissociation of Activity of Ileal and Liver FXR Mediates Metabolic Effects in a Rodent Model of Bariatric Surgery. (2013) (0)
- Combinatorial therapy with BAR502 and UDCA resets FXR and GPBAR1 signaling and reverses liver histopathology in a model of NASH (2023) (0)
- Recombinant galectin-1 prevents experimental colitis in mice via T cell apoptosis (2000) (0)
- An NO-derivative of acetaminophen, NCX-701, spares the liver by inhibiting fasdependent apoptosis (2001) (0)
- NCX-1000, an NO derivative of UDCA, refeases NO and protects against portal hypertension by inhibiting hepatic stellate cell contraction (2001) (0)
- the Ritonavir pro-atherogenetic activity prevention by PPAR alpha agonist in ApoE-/-mice is mediated by CD36 (2010) (0)
- NO-Releasing NSAIDs Modulate Cytokine Secretion (2001) (0)
- S2070 FXR Activation Corrects Immune-Dysfunction and Attenuates Inflammation in a Rodent Model of Hepatitis (2009) (0)
- Subject Index Vol. 66, 2002 (2003) (0)
- 241 - GPBAR1 (TGR5) is a Modulator of Liver Immunity and Reverses Liver Inflammation in a Mouse Models of Acute Hepatitis (2018) (0)
- Nitric oxide protects against HIV gp120 endothelial injury (2010) (0)
- An no-derivative of ursodeoxycholic acid exerts anti-apoptotic effects by inhibiting fas-dependent activation of liver (2000) (0)
- Tyrosine Kinase-Dependent Mechanism Induction of L-Selectin Shedding by a Endothelium Under Nonstatic Conditions: Salicylates Inhibit T Cell Adhesion on (2000) (0)
- Gastrointestinal safety and anti-inflammatory activity of HCT-1026, NO-releasing flurbiprofen, in healthy humans volunteers (2004) (0)
- Treatment of Fibrosis with FXR ligands. (2005) (0)
- Contents Vol. 66, 2002 (2002) (0)
- Sections Vol. 66, 2002 (2003) (0)
- Nitric oxide modulates pepsinogen secretion induced by Ca2+-mediated agents by isolated chief cells. (1995) (0)
- Rescuing inflammation By Inflammasome Inhibitors. (2022) (0)
- Gpbar1 agonism promotes a Pgc-1α-dependent browning of white adipose tissue and energy expenditure and reverses diet-induced steatohepatitis in mice (2017) (0)
- 11 P An no-derivative of UDCA (NCX-1000) modulates the dinamic component of intrahepatic resistance in a rat model of liver chirrosis (2002) (0)
- The Bile Acids Receptor TGR5 is an Essential Modulator of Intestinal Membrane Permeability and Exerts Anti-Inflammatory Activities in Rodent Model of Colitis (2011) (0)
- Nitric Oxide-derived NSAIDs inhibit ICE-like Cysteine Proteasis and protect from acute liver injury in a mice model of T-cell mediated hepatitis (1998) (0)
- [Effects of TRH and secretin on serum output of immunoreactive trypsin: evidence of a direct inhibitory mechanism]. (1987) (0)
- Anti-HIV Protease Inhibitors Interact With NSAIDs and Exacerbate Small Intestine Enteropathy Induced by NSAIDs (2011) (0)
- The vagal control of gallbladder motility is impaired in diabetics with autonomic neuropathy. (1990) (0)
- Discovery of gymnemic acids as a new class of liver X receptor antagonists (2015) (0)
- Editorial [Hot Topic: Hydrogen Sulfide: From Molecular Biology to Pharmacology Guest Editor: Stefano Fiorucci)] (2011) (0)
- Role of maraviroc in a dyslipidemic murine model of atherosclerosis RTV-induced (2012) (0)
- Protective effects of granulocyte macrophage colony stimulating factor (gm-Csf) in Hapten-induced colitis (2005) (0)
- Helicobacter p ylori and non-steroidal anti-inflammatory drugs (2000) (0)
- Mo1916 BAR 501, a Novel GPBAR1 Ligand, Reverses Intestinal and Liver Inflammatory Models Demonstrating That GPBAR1 Is an Essential Modulator of Innate Immunity in Entero-Hepatic Tissues (2016) (0)
- Function of CD44 variant isoforms in human T cell. (1994) (0)
- Nitric oxide inhibits hepatic stellate cell dependent tumor angiogenesis in primary and metastatic liver cancer (2005) (0)
- Tu1304: ROLE OF A DUAL GPBAR1/CYSLT1R MODULATOR REVERSES LIVER INJURY AND FIBROSIS IN A RODENT MODEL OF NASH (2022) (0)
- Analysis of oral and gut microbiota in children with dental cavities by Ion torrent 16s rRNA sequencing (2021) (0)
- Notice of Retraction: ‘Liver delivery of NO by NCX‐1000 protects against acute liver failure and mitochondrial dysfunction induced by APAP in mice’ (Br J Pharmacol 143; 33–42; 2004) (2009) (0)
- COX-2 selective inhibitors cause gastric damage in aspirin treated rats Protective effect of nitroaspirin (NCX-4016) (2001) (0)
- An update in H(2)S in physiology, pathophysiology and pharmacology. (2011) (0)
- Ultrasound and stomach (1994) (0)
- Sa1518 – Mechanism of Acute Liver Decompensation Caused by Obeticholic Acid in Cholestasis is Fxr Dependent (2019) (0)
- [Control using omeprazole in a case of upper digestive hemorrhage, induced by erosive uremic hemorrhagic gastritis resistant to conventional therapy]. (1989) (0)
- 542 Farnesoid X Receptor Regulates Glutamate Metabolism: Relevance for Hepatic Encephalopathy (2010) (0)
- Farnesoid X Receptor Dependent Regulation of MMP9 in Blood Outgrowth Endothelial Cells (2006) (0)
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What Schools Are Affiliated With Stefano Fiorucci?
Stefano Fiorucci is affiliated with the following schools:
