Stephanie S. Watowich
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Why Is Stephanie S. Watowich Influential?
(Suggest an Edit or Addition)According to Wikipedia, Stephanie S. Watowich is an American immunologist. Watowich is the deputy chair of the Department of Immunology at MD Anderson Cancer Center in Houston, TX. She is a professor within the department as well and serves as the co-director of the Center for Inflammation and Cancer at the MD Anderson Cancer Center. Watowich’s research has focused on transcriptional control of innate immunity, with specific interest in the actions of the cytokine-activated STAT transcriptional regulators.
Stephanie S. Watowich's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Essential autocrine regulation by IL-21 in the generation of inflammatory T cells (2007) (1588)
- T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. (2008) (1585)
- STAT3 Regulates Cytokine-mediated Generation of Inflammatory Helper T Cells* (2007) (1421)
- Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. (2008) (1170)
- Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. (2008) (1155)
- Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. (2009) (1131)
- CCR6 Regulates the Migration of Inflammatory and Regulatory T Cells1 (2008) (471)
- HIF-1α, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas (2005) (393)
- STAT3 signaling in immunity. (2016) (361)
- The transcriptional regulators Id2 and Id3 control the formation of distinct memory CD8+ T cell subsets (2011) (338)
- Granulocyte colony-stimulating factor: molecular mechanisms of action during steady state and 'emergency' hematopoiesis. (2008) (333)
- BRAF Inhibition Increases Tumor Infiltration by T cells and Enhances the Antitumor Activity of Adoptive Immunotherapy in Mice (2012) (320)
- Generation of T Follicular Helper Cells Is Mediated by Interleukin-21 but Independent of T Helper 1, 2, or 17 Cell Lineages (DOI: 10.1016/j.immuni.2008.05.009) (2008) (258)
- General Nature of the STAT3-Activated Anti-Inflammatory Response1 (2006) (231)
- Complex regulation of heat shock- and glucose-responsive genes in human cells (1988) (227)
- Enhancer-Mediated Control of Macrophage-Specific Arginase I Expression1 (2004) (221)
- The signal transducer STAT5 inhibits plasmacytoid dendritic cell development by suppressing transcription factor IRF8. (2008) (214)
- STAT5 Protein Negatively Regulates T Follicular Helper (Tfh) Cell Generation and Function* (2012) (210)
- STAT3 controls myeloid progenitor growth during emergency granulopoiesis. (2010) (208)
- Cytokine receptor signal transduction and the control of hematopoietic cell development. (1996) (199)
- STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils. (2006) (190)
- USP15 stabilizes MDM2 to mediate cancer cell survival and inhibit antitumor T cell responses (2014) (185)
- Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response (2021) (181)
- STAT 3 Regulates Cytokine-mediated Generation of Inflammatory Helper T Cells * (2007) (164)
- Mechanisms regulating dendritic cell specification and development (2010) (163)
- Arginine Usage in Mycobacteria-Infected Macrophages Depends on Autocrine-Paracrine Cytokine Signaling (2010) (145)
- IL6 Blockade Reprograms the Lung Tumor Microenvironment to Limit the Development and Progression of K-ras-Mutant Lung Cancer. (2016) (143)
- Cutting Edge: IL-10-Independent STAT3 Activation by Toxoplasma gondii Mediates Suppression of IL-12 and TNF-α in Host Macrophages1 (2005) (142)
- STAT3 controls the neutrophil migratory response to CXCR2 ligands by direct activation of G-CSF-induced CXCR2 expression and via modulation of CXCR2 signal transduction. (2009) (126)
- Saturation Mutagenesis of the WSXWS Motif of the Erythropoietin Receptor (*) (1996) (121)
- Cutting Edge: A Transcriptional Repressor and Corepressor Induced by the STAT3-Regulated Anti-Inflammatory Signaling Pathway1 (2007) (116)
- The signaling suppressor CIS controls proallergic T cell development and allergic airway inflammation (2013) (113)
- IL-10 Suppresses Mast Cell IgE Receptor Expression and Signaling In Vitro and In Vivo1 (2008) (108)
- Mutations in the cofilin partner Aip1/Wdr1 cause autoinflammatory disease and macrothrombocytopenia. (2007) (105)
- Self assembly of the transmembrane domain promotes signal transduction through the erythropoietin receptor (2001) (104)
- Noncanonical NF-κB pathway controls the production of type I interferons in antiviral innate immunity. (2014) (101)
- The signal transducers STAT5 and STAT3 control expression of Id2 and E2-2 during dendritic cell development. (2012) (87)
- Cutting edge: a transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway (2008) (81)
- IL-10-independent STAT3 activation by Toxoplasma gondii mediates suppression of IL-12 and TNF-alpha in host macrophages. (2005) (80)
- IL-6 signaling via the STAT3/SOCS3 pathway: Functional Analysis of the Conserved STAT3 N-domain (2006) (78)
- Increased cell surface expression and enhanced folding in the endoplasmic reticulum of a mutant erythropoietin receptor. (1995) (73)
- The Erythropoietin Receptor (2011) (67)
- Flux of the paramyxovirus hemagglutinin-neuraminidase glycoprotein through the endoplasmic reticulum activates transcription of the GRP78-BiP gene (1991) (61)
- Erythropoietin receptor mutations associated with familial erythrocytosis cause hypersensitivity to erythropoietin in the heterozygous state. (1999) (61)
- Control of Myeloid-specific Integrin αMβ2 (CD11b/CD18) Expression by Cytokines Is Regulated by Stat3-dependent Activation of PU.1* (2002) (60)
- Transcription of the activating receptor NKG2D in natural killer cells is regulated by STAT3 tyrosine phosphorylation. (2014) (60)
- FGL2 promotes tumor progression in the CNS by suppressing CD103+ dendritic cell differentiation (2019) (58)
- The kinase TBK1 functions in dendritic cells to regulate T cell homeostasis, autoimmunity, and antitumor immunity (2017) (58)
- Combined Inhibition of STAT3 and DNA Repair in Palbociclib-Resistant ER-Positive Breast Cancer (2019) (58)
- STAT3 inhibitors: finding a home in lymphoma and leukemia. (2014) (57)
- Endogenous suppression of mast cell development and survival by IL‐4 and IL‐10 (2009) (53)
- Innate immune regulation by STAT‐mediated transcriptional mechanisms (2014) (52)
- Sex specific function of epithelial STAT3 signaling in pathogenesis of K-ras mutant lung cancer (2018) (52)
- Cell-intrinsic role for IFN-α-STAT1 signals in regulating murine Peyer patch plasmacytoid dendritic cells and conditioning an inflammatory response. (2011) (51)
- Src activation of Stat3 is an independent requirement from NF-κB activation for constitutive IL-8 expression in human pancreatic adenocarcinoma cells (2006) (47)
- Cytokine Signaling through Stat3 Activates Integrins, Promotes Adhesion, and Induces Growth Arrest in the Myeloid Cell Line 32D* (2000) (46)
- The histone deacetylase inhibitor valproic acid inhibits NKG2D expression in natural killer cells through suppression of STAT3 and HDAC3 (2017) (43)
- Vaccine efficacy against primary and metastatic cancer with in vitro-generated CD103+ conventional dendritic cells (2020) (43)
- A Ras homologue member I directly inhibits signal transducers and activators of transcription 3 translocation and activity in human breast and ovarian cancer cells. (2005) (41)
- miR-22 Controls Irf8 mRNA Abundance and Murine Dendritic Cell Development (2012) (37)
- CCR 6 Regulates the Migration of Inflammatory and Regulatory T Cells 1 (2008) (36)
- Differential regulation of SOCS genes in normal and transformed erythroid cells (2003) (36)
- STAT3 restrains RANK- and TLR4-mediated signaling by suppressing expression of the E2 ubiquitin ligase Ubc13 (2014) (34)
- The Erythropoietin Receptor: Molecular Structure and Hematopoietic Signaling Pathways (2011) (34)
- Identification of a cytoplasmic motif in the erythropoietin receptor required for receptor internalization (1998) (33)
- Activation of erythropoietin signaling by receptor dimerization. (1999) (33)
- Stat3 promotes the development of erythroleukemia by inducing Pu.1 expression and inhibiting erythroid differentiation (2009) (33)
- 15‐Lipoxygenase‐1 suppression of colitis‐associated colon cancer through inhibition of the IL‐6/STAT3 signaling pathway (2015) (32)
- Role of the Fractalkine Receptor in CNS Autoimmune Inflammation: New Approach Utilizing a Mouse Model Expressing the Human CX3CR1I249/M280 Variant (2018) (31)
- STAT3 restrains RANK- and TLR4-mediated signalling by suppressing expression of the E2 ubiquitin-conjugating enzyme Ubc13 (2014) (31)
- Neutrophils Regulate Humoral Autoimmunity by Restricting Interferon-γ Production via the Generation of Reactive Oxygen Species. (2015) (30)
- Molecular regulation of dendritic cell development and function in homeostasis, inflammation, and cancer. (2019) (30)
- CXCR5+CD8+ T cells are a distinct functional subset with antitumor activity (2019) (29)
- G‐CSF‐activated STAT3 enhances production of the chemokine MIP‐2 in bone marrow neutrophils (2012) (28)
- Control of myeloid-specific integrin alpha Mbeta 2 (CD11b/CD18) expression by cytokines is regulated by Stat3-dependent activation of PU.1. (2002) (28)
- Oligomerization and Scaffolding Functions of the Erythropoietin Receptor Cytoplasmic Tail* (1999) (27)
- PPARD and Interferon Gamma Promote Transformation of Gastric Progenitor Cells and Tumorigenesis in Mice. (2019) (27)
- Preventing abnormal NF-κB activation and autoimmunity by Otub1-mediated p100 stabilization (2019) (25)
- Erythropoietin receptors that signal through Stat5 or Stat3 support fetal liver and adult erythropoiesis: lack of specificity of stat signals during red blood cell development. (2000) (22)
- Critical regulation of early Th17 cell differentiation by IL-1 signaling (48.24) (2009) (20)
- 112 Essential Autocrine Regulation by IL-21 in the Generation of Inflammatory T Cells (2007) (20)
- Bypassing STAT3-mediated inhibition of the transcriptional regulator ID2 improves the antitumor efficacy of dendritic cells (2016) (19)
- Cell Surface Organization of the Erythropoietin Receptor Complex Differs Depending on its Mode of Activation* (1997) (18)
- Epitope tagging of the human endoplasmic reticulum HSP70 protein, BiP, to facilitate analysis of BiP--substrate interactions. (1995) (17)
- Macrophage conditioned medium promotes colorectal cancer stem cell phenotype via the hedgehog signaling pathway (2018) (16)
- MicroRNA-22 controls interferon alpha production and erythroid maturation in response to infectious stress in mice. (2017) (15)
- Hematopoietic cell survival signals are elicited through non-tyrosine-containing sequences in the membrane-proximal region of the erythropoietin receptor (EPOR) by a Stat5-dependent pathway. (2003) (14)
- Cytokine signals through STAT3 promote expression of granulocyte secondary granule proteins in 32D cells. (2005) (14)
- Oncogene cooperativity in Friend erythroleukemia: erythropoietin receptor activation by the env gene of SFFV leads to transcriptional upregulation of PU.1, independent of SFFV proviral insertion (2002) (12)
- Histone Deacetylase Inhibitors and IL21 Cooperate to Reprogram Human Effector CD8+ T Cells to Memory T Cells (2020) (11)
- Tonic interferon restricts pathogenic IL-17-driven inflammatory disease via balancing the microbiome (2021) (11)
- Diversification of dendritic cell subsets (2013) (10)
- Dominant action of mutated erythropoietin receptors on differentiation in vitro and erythroleukemia development in vivo (2000) (10)
- STAT3 Inhibits CD103+ cDC1 Vaccine Efficacy in Murine Breast Cancer (2020) (9)
- A STATus report on DC development (2012) (9)
- Genetic rescue of lineage-balanced blood cell production reveals a crucial role for STAT3 antiinflammatory activity in hematopoiesis (2018) (8)
- Loss of c‐Kit and bone marrow failure upon conditional removal of the GATA‐2 C‐terminal zinc finger domain in adult mice (2016) (8)
- Intestinal toxicity to CTLA-4 blockade driven by IL-6 and myeloid infiltration. (2022) (8)
- Macrophage-Specific Arginase I Expression Enhancer-Mediated Control of Murray (2004) (7)
- Author Correction: FGL2 promotes tumor progression in the CNS by suppressing CD103+ dendritic cell differentiation (2019) (6)
- Interplay between Estrogen and Stat3/NF-κB Driven Immunomodulation in Lung Cancer. (2020) (6)
- Dendritic cells: Transcriptional control of plasmacytoid dendritic cell development by E2‐2 (2009) (4)
- Crosstalk between STAT3 and RANK signaling pathways during osteoclastogenesis (174.7) (2012) (4)
- G-CSF Receptor Structure, Function, and Intracellular Signal Transduction (2012) (4)
- Immune landscape of a genetically engineered murine model of glioma compared with human glioma (2022) (3)
- Jak-STAT Signaling Pathways (2016) (3)
- Targeting IL-1β as an immunopreventive and therapeutic modality for K-ras–mutant lung cancer (2022) (3)
- Direct and indirect type-1 arginase (Arg1) induction following Mycobacterium bovis (BCG) infection (2009) (2)
- Checkpoint inhibitors as immunotherapy for fungal infections: Promises, challenges, and unanswered questions (2022) (2)
- STAT3 Activation Promotes NK Cell Proliferation, NKG2D Expression, and NK Cell Antitumor Activity (2010) (2)
- STAT3 Controls Neutrophil Progenitor Growth and Differentiation During Emergency Granulopoiesis. (2009) (2)
- Outcome of concurrent treatment with a-CTLA4 and metronidazole in murine model of colon adenocarcinoma. (2021) (2)
- Microbial messaging to the marrow. (2014) (2)
- Doxorubicin-induced cardiotoxicity is mediated by neutrophils through release of neutrophil elastase (2022) (2)
- Truncated Human EpoR Causes Polycythemia in Fetal Erythropoiesis through Stat5 Hyperactivation. (2005) (1)
- CD103+ cDC1 vaccine efficacy in murine breast cancer is inhibited by STAT3 (2020) (1)
- STAT3 Inhibits Autocrine IFN Signaling in Type I Conventional Dendritic Cells (2022) (1)
- Microbiome influencers of checkpoint blockade–associated toxicity (2023) (1)
- Interleukin-8 is regulated by a Src/STAT3 pathway in pancreatic adenocarcinoma cells that is NF-κB independent (2006) (1)
- Abstract 5396: Interferon-α receptor dependent and independent inhibition of type I interferon production in plasmacytoid dendritic cells from mice and melanoma patients (2012) (1)
- Neuroprotective roles of fractalkine in multiple sclerosis: Characterization of novel humanized animal model (2018) (0)
- Author Correction: FGL2 promotes tumor progression in the CNS by suppressing CD103+ dendritic cell differentiation (2019) (0)
- IL-15 enhances the anti-tumor effect of human tumor antigen-specific T cells by cellular senescence delay (TUM2P.880) (2014) (0)
- Abstract 413: Targeting IL-6 as a preventive and therapeutic strategy for K-ras mutant lung cancer (2015) (0)
- STAT3 protects HSCs from intrinsic interferon signaling and loss of long-term blood-forming activity (2023) (0)
- Roles for STAT5 in homeostasis and function of CD103+cDC1s in non-lymphoid organs (2021) (0)
- Abstract A13: Pharmacologic targeting of IL-6 suppresses tumor progression in a non-small cell lung cancer mouse model with K-ras mutation through re-educating the tumor microenvironment. (2014) (0)
- Essential role of STAT3 in the upregulation of CD28 expression by IL-21 (IRM6P.658) (2015) (0)
- Regulation of Dendritic Cell Development by STATs (2012) (0)
- Abstract 1959: 15-lipoxygenase-1 suppression of colitis-associated colon cancer through inhibition of the IL-6/STAT3 signaling pathway (2015) (0)
- Regulation and function of Id2 in plasmacytoid dendritic cells. (2022) (0)
- Abstract 4177: Th17 inhibition with interleukin 6 blockade decouples immunotoxicity from tumor immunity (2022) (0)
- Stat3 Is Required for In Vivo G-CSF-Responsiveness and Neutrophil Function. (2004) (0)
- Assessing the development of murine plasmacytoid dendritic cells in Peyer's patches using adoptive transfer of hematopoietic progenitors. (2014) (0)
- Graduate Training Program in Basic Research Employing Biotechnology (1989) (0)
- STAT3 Protects Hematopoietic Stem and Progenitor Cell Function in Non-Inflamed Conditions (2022) (0)
- Immune landscape of a genetically-engineered murine model of glioma relative to human glioma by single-cell sequencing (2020) (0)
- Abstract 1348: LMW-E induction and crosstalk with immune cells potentiates local immune responses leading to an immunosuppressive microenvironment at the early stages of breast tumorigenesis in mouse models (2022) (0)
- IMMUNOBIOLOGY Transcription of the activating receptor NKG 2 D in natural killer cells is regulated by STAT 3 tyrosine phosphorylation (2014) (0)
- Targeting PD-L2-RGMb overcomes microbiome-related immunotherapy resistance. (2023) (0)
- Cytokine & Growth Factor Reviews (2016) (0)
- FGL2 promotes tumor progression in the CNS by suppressing CD103+ dendritic cell differentiation (2019) (0)
- Preventing abnormal NF-κB activation and autoimmunity by Otub1-mediated p100 stabilization (2019) (0)
- Roles for Leukemia-inhibitory factor receptor signaling in intestinal immunity (2020) (0)
- disease and macrothrombocytopenia Mutations in the cofilin partner Aip1/Wdr1 cause autoinflammatory (2013) (0)
- Introduction to the Special Issue: The tumor microenvironment and molecular regulation of innate immune cells. (2019) (0)
- Knockout immune regulator FGL2 in tumor cells impairs tumor progression in the CNS by facilitating CD103+ dendritic cell differentiation (2019) (0)
- STAT3 and IL-10 inhibit interferon signaling in type 1 conventional dendritic cells (2021) (0)
- Abstract P3-10-02: Neutrophil elastase as a therapeutic target to inhibit metastasis in breast cancer (2020) (0)
- Regulation of Id2 gene expression in plasmacytoid dendritic cells (2020) (0)
- Effects of different TLR Agonists on in vivo cDC1 and in vivo cDC2 Activation (2021) (0)
- Antigen-presenting type-I conventional dendritic cells facilitate curative checkpoint blockade immunotherapy in pancreatic cancer (2023) (0)
- Signaling through the membrane-proximal region of the erythropoietin receptor supports 32D cell survival (2000) (0)
- Increased cellsurface expression andenhanced folding inthe endoplasmic reticulum ofamutanterythropoietin receptor (1995) (0)
- Abstract 2887: Macrophage conditioned medium promotes colon cancer stem cell phenotype via the hedgehog signaling pathway (2017) (0)
- Investigating the impact of TLR ligand induced Id2 expression in dendritic cell development and function (2021) (0)
- Inflammatory and Regulatory T Cells CCR6 Regulates the Migration of (0)
- Suppression of IL-12 and TNF- Activation by Toxoplasma gondii Mediates Cutting Edge: IL-10-Independent STAT3 (2013) (0)
- Molecular Regulation of Adult Hematopoiesis By GATA-2 (2014) (0)
- STAT3 and STAT5 guide key transcriptional and epigenetic responses during dendritic cell development (111.37) (2012) (0)
- Abstract 3974: Gender specific function of epithelial IL-6-STAT3 pathway in K-ras mutant lung cancer (2017) (0)
- Neutrophils Regulate Hum oral Autoimmunity by Restricting Interferon-g Production via the Generation of Reactive Oxygen Species (0)
- Direct and indirect type-1 arginase (Arg1) induction following Mycobacterium bovis (BCG) infection (43.1) (2009) (0)
- Erythropoietin (2020) (0)
- Sex specific function of epithelial STAT3 signaling in pathogenesis of K-ras mutant lung cancer (2018) (0)
- Abstract 323: Combined inhibition of STAT-3 & DNA repair in palbociclib resistant breast cancer (2019) (0)
- STAT3 modulates metabolic programming of inflammation-induced macrophages (2020) (0)
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What Schools Are Affiliated With Stephanie S. Watowich?
Stephanie S. Watowich is affiliated with the following schools:
