Stephen B. Liggett

Stephen B. Liggett's AcademicInfluence.com Rankings

Stephen B. Liggett

Medical

#2058

World Rank

#2455

Historical Rank

Pharmacology

#214

World Rank

#254

Historical Rank

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Medical

Stephen B. Liggett's Degrees

Bachelors Chemistry University of Cincinnati

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Stephen B. Liggett's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness. (2000) (1018)
Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties. (1994) (805)
Transgenic Gαq overexpression induces cardiac contractile failure in mice (1997) (621)
Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial (2004) (618)
Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects. (1993) (608)
A Gain-of-function Polymorphism in a G-protein Coupling Domain of the Human β1-Adrenergic Receptor* (1999) (592)
The effect of polymorphisms of the beta(2)-adrenergic receptor on the response to regular use of albuterol in asthma. (2000) (565)
Enhanced Galphaq signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failure. (1998) (561)
PKC-α regulates cardiac contractility and propensity toward heart failure (2004) (527)
Synergistic Polymorphisms of β1- and α2C-Adrenergic Receptors and the Risk of Congestive Heart Failure (2002) (495)
A polymorphism of the human beta 2-adrenergic receptor within the fourth transmembrane domain alters ligand binding and functional properties of the receptor. (1993) (485)
Sequencing and Analyses of All Known Human Rhinovirus Genomes Reveal Structure and Evolution (2009) (438)
Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human. (2003) (438)
Influence of beta 2-adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells. (1995) (435)
Early and delayed consequences of beta(2)-adrenergic receptor overexpression in mouse hearts: critical role for expression level. (2000) (410)
A polymorphism within a conserved β1-adrenergic receptor motif alters cardiac function and β-blocker response in human heart failure (2006) (408)
Genetic polymorphisms of the beta 2-adrenergic receptor in nocturnal and nonnocturnal asthma. Evidence that Gly16 correlates with the nocturnal phenotype. (1995) (399)
β1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure (2003) (356)
PKC-alpha regulates cardiac contractility and propensity toward heart failure. (2004) (347)
The Ile164 beta2-adrenergic receptor polymorphism adversely affects the outcome of congestive heart failure. (1998) (345)
A GRK5 polymorphism that inhibits β-adrenergic receptor signaling is protective in heart failure (2008) (339)
Phosphorylation and desensitization of the human beta 1-adrenergic receptor. Involvement of G protein-coupled receptor kinases and cAMP-dependent protein kinase. (1995) (326)
Pharmacology and physiology of human adrenergic receptor polymorphisms. (2003) (317)
Association of Glu 27 β2-adrenoceptor polymorphism with lower airway reactivity in asthmatic subjects (1995) (313)
Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids. (2004) (310)
Bitter taste receptors on airway smooth muscle bronchodilate by a localized calcium flux and reverse obstruction (2010) (306)
Simultaneous coupling of alpha 2-adrenergic receptors to two G-proteins with opposing effects. Subtype-selective coupling of alpha 2C10, alpha 2C4, and alpha 2C2 adrenergic receptors to Gi and Gs. (1992) (297)
Polymorphisms of the 5' leader cistron of the human beta2-adrenergic receptor regulate receptor expression. (1998) (286)
Transgenic Galphaq overexpression induces cardiac contractile failure in mice. (1997) (260)
A polymorphism within a conserved beta(1)-adrenergic receptor motif alters cardiac function and beta-blocker response in human heart failure. (2006) (243)
Low- and high-level transgenic expression of β2-adrenergic receptors differentially affect cardiac hypertrophy and function in Gαq-overexpressing mice (1999) (227)
Structural basis for receptor subtype-specific regulation revealed by a chimeric beta 3/beta 2-adrenergic receptor. (1993) (220)
beta2-Adrenergic receptor haplotypes in mild, moderate and fatal/near fatal asthma. (1998) (210)
Amino Acid 49 Polymorphisms of the Human &bgr; 1 -Adrenergic Receptor Affect Agonist-Promoted Trafficking (2002) (197)
Myocardial signaling defects and impaired cardiac function of a human beta 2-adrenergic receptor polymorphism expressed in transgenic mice. (1996) (191)
Decompensation of Pressure-Overload Hypertrophy in Gαq-Overexpressing Mice (1998) (190)
A Four Amino Acid Deletion Polymorphism in the Third Intracellular Loop of the Human α2C-Adrenergic Receptor Confers Impaired Coupling to Multiple Effectors* (2000) (182)
Molecular modeling, organ culture and reverse genetics for a newly identified human rhinovirus C (2011) (180)
Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure. (2002) (173)
Sequence, haplotype, and association analysis of ADRbeta2 in a multiethnic asthma case-control study. (2006) (168)
The glutamine 27 beta2-adrenoceptor polymorphism is associated with elevated IgE levels in asthmatic families. (1997) (167)
Polymorphisms of the β2-Adrenergic Receptor Determine Exercise Capacity in Patients With Heart Failure (2000) (164)
Sustained Activation of a G Protein-coupled Receptor via “Anchored” Agonist Binding (1996) (162)
Polymorphisms of the β2-Adrenergic Receptor and Asthma (1997) (158)
Polymorphic Deletion of Three Intracellular Acidic Residues of the α2B-Adrenergic Receptor Decreases G Protein-coupled Receptor Kinase-mediated Phosphorylation and Desensitization* (2001) (152)
Pharmacogenetics of Beta-1- and Beta-2-Adrenergic Receptors (2000) (145)
The alpha 1C-adrenergic receptor: characterization of signal transduction pathways and mammalian tissue heterogeneity. (1991) (144)
Contribution of ligand structure to activation of alpha 2-adrenergic receptor subtype coupling to Gs. (1994) (144)
Lack of association between adrenergic receptor genotypes and survival in heart failure patients treated with carvedilol or metoprolol. (2008) (139)
Airway smooth muscle prostaglandin-EP1 receptors directly modulate beta2-adrenergic receptors within a unique heterodimeric complex. (2006) (133)
Polymorphisms of the beta1-adrenergic receptor predict exercise capacity in heart failure. (2002) (133)
beta2-adrenergic receptor polymorphisms at amino acid 16 differentially influence agonist-stimulated blood pressure and peripheral blood flow in normal individuals. (2000) (133)
Protein Kinase C&agr; Negatively Regulates Systolic and Diastolic Function in Pathological Hypertrophy (2003) (133)
Phosphorylation Barcoding as a Mechanism of Directing GPCR Signaling (2011) (128)
β2-Adrenergic Receptor Pharmacogenetics (2000) (124)
Antithetic regulation by β-adrenergic receptors of Gq receptor signaling via phospholipase C underlies the airway β-agonist paradox (2003) (122)
Long-term agonist exposure induces upregulation of beta 3-adrenergic receptor expression via multiple cAMP response elements. (1992) (122)
Subtype-selective desensitization of alpha 2-adrenergic receptors. Different mechanisms control short and long term agonist-promoted desensitization of alpha 2C10, alpha 2C4, and alpha 2C2. (1992) (120)
Desensitization of Myocardial β‐Adrenergic Receptors During Cardiopulmonary Bypass: Evidence for Early Uncoupling and Late Downregulation (1991) (117)
Four Consecutive Serines in the Third Intracellular Loop Are the Sites for β-Adrenergic Receptor Kinase-mediated Phosphorylation and Desensitization of the α2A-Adrenergic Receptor (*) (1995) (117)
Beta 1- and beta 2-adrenergic receptors display subtype-selective coupling to Gs. (1992) (116)
ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts. (2008) (114)
Effect of Polymorphism of the β2-Adrenergic Receptor on Response to Regular Use of Albuterol in Asthma (2001) (113)
Interactions Between Phospholamban and &bgr;-Adrenergic Drive May Lead to Cardiomyopathy and Early Mortality (2001) (113)
Coupling of a mutated form of the human beta 2-adrenergic receptor to Gi and Gs. Requirement for multiple cytoplasmic domains in the coupling process. (1991) (112)
The pharmacogenetics of beta2-adrenergic receptors: relevance to asthma. (2000) (112)
Functional properties of the rat and human beta 3-adrenergic receptors: differential agonist activation of recombinant receptors in Chinese hamster ovary cells. (1992) (111)
Extraoral bitter taste receptors as mediators of off‐target drug effects (2012) (111)
Analysis of the complete genome sequences of human rhinovirus. (2010) (109)
Cardiac Specific Overexpression of Transglutaminase II (Gh) Results in a Unique Hypertrophy Phenotype Independent of Phospholipase C Activation* (1999) (108)
Sites in the third intracellular loop of the alpha 2A-adrenergic receptor confer short term agonist-promoted desensitization. Evidence for a receptor kinase-mediated mechanism. (1992) (107)
Racial differences in the frequencies of cardiac β1‐adrenergic receptor polymorphisms: Analysis of c145A>G and c1165G>C (1999) (106)
A proline-rich region of the third intracellular loop imparts phenotypic beta 1-versus beta 2-adrenergic receptor coupling and sequestration. (1994) (105)
Effects of thyroid hormone on cardiac beta-adrenergic responsiveness in conscious baboons. (1997) (105)
Identification of a Gs coupling domain in the amino terminus of the third intracellular loop of the alpha 2A-adrenergic receptor. Evidence for distinct structural determinants that confer Gs versus Gi coupling. (1995) (103)
Molecular properties and pharmacogenetics of a polymorphism of adenylyl cyclase type 9 in asthma: interaction between beta-agonist and corticosteroid pathways. (2005) (101)
Dilated Cardiomyopathy Mutant Tropomyosin Mice Develop Cardiac Dysfunction With Significantly Decreased Fractional Shortening and Myofilament Calcium Sensitivity (2007) (101)
Histamine N-methyltransferase pharmacogenetics: association of a common functional polymorphism with asthma. (2000) (97)
Heterogeneity in β-Adrenergic Receptor Kinase Expression in the Lung Accounts for Cell-specific Desensitization of the β2-Adrenergic Receptor* (1997) (92)
Implications of Genetic Variability of Human β2-adrenergic Receptor Structure (1995) (91)
Overview of the pharmacogenetics of asthma treatment (2006) (90)
Pharmacogenetic applications of the Human Genome project (2001) (89)
An &agr;2C-Adrenergic Receptor Polymorphism Alters the Norepinephrine-Lowering Effects and Therapeutic Response of the &bgr;-Blocker Bucindolol in Chronic Heart Failure (2010) (88)
Mechanisms of impaired beta-adrenergic receptor signaling in G(alphaq)-mediated cardiac hypertrophy and ventricular dysfunction. (2000) (87)
The Ile164 β2-adrenoceptor polymorphism alters salmeterol exosite binding and conventional agonist coupling to Gs (2001) (85)
Increased fat and skeletal muscle beta-adrenergic receptors but unaltered metabolic and hemodynamic sensitivity to epinephrine in vivo in experimental human thyrotoxicosis. (1989) (83)
Alpha 2A-adrenergic receptor stimulated calcium release is transduced by Gi-associated G(beta gamma)-mediated activation of phospholipase C. (1997) (83)
Molecular and Functional Characterization of a Novel Cardiac-Specific Human Tropomyosin Isoform (2009) (83)
TAS2R activation promotes airway smooth muscle relaxation despite β(2)-adrenergic receptor tachyphylaxis. (2012) (82)
β2-Agonist Induced cAMP Is Decreased in Asthmatic Airway Smooth Muscle Due to Increased PDE4D (2011) (81)
The palmitoylated cysteine of the cytoplasmic tail of alpha 2A-adrenergic receptors confers subtype-specific agonist-promoted downregulation. (1994) (79)
G Protein-coupled Receptor Kinase Specificity for Phosphorylation and Desensitization of α2-Adrenergic Receptor Subtypes* (1996) (79)
Defining an olfactory receptor function in airway smooth muscle cells (2016) (78)
Chimeric Mutagenesis of Putative G-protein Coupling Domains of the α2A-Adrenergic Receptor (1996) (76)
An Asn to Lys Polymorphism in the Third Intracellular Loop of the Human α2A-Adrenergic Receptor Imparts Enhanced Agonist-promoted Gi Coupling* (2000) (74)
Decompensation of pressure-overload hypertrophy in G alpha q-overexpressing mice. (1998) (73)
Crosstalk between Gi and Gq/Gs pathways in airway smooth muscle regulates bronchial contractility and relaxation. (2007) (73)
Alternative splicing of the G protein-coupled receptor superfamily in human airway smooth muscle diversifies the complement of receptors (2008) (73)
Common Genomic Response in Different Mouse Models of &bgr;-Adrenergic–Induced Cardiomyopathy (2003) (72)
Hierarchy of Polymorphic Variation and Desensitization Permutations Relative to β1- and β2-Adrenergic Receptor Signaling* (2003) (69)
Altered patterns of agonist-stimulated cAMP accumulation in cells expressing mutant beta 2-adrenergic receptors lacking phosphorylation sites. (1989) (68)
Transgenic Overexpression of β2-Adrenergic Receptors in Airway Smooth Muscle Alters Myocyte Function and Ablates Bronchial Hyperreactivity* (1999) (68)
Bitter taste receptor function in asthmatic and nonasthmatic human airway smooth muscle cells. (2014) (68)
Update on current concepts of the molecular basis of beta2-adrenergic receptor signaling. (2002) (68)
Molecular Mechanisms of β2-Adrenergic Receptor Function and Regulation (2005) (66)
Altering the receptor-effector ratio by transgenic overexpression of type V adenylyl cyclase: enhanced basal catalytic activity and function without increased cardiomyocyte beta-adrenergic signalling. (1999) (66)
Characterization of beta-adrenergic receptors of human skeletal muscle obtained by needle biopsy. (1988) (66)
Human alpha 2-adrenergic receptor subtype distribution: widespread and subtype-selective expression of alpha 2C10, alpha 2C4, and alpha 2C2 mRNA in multiple tissues. (1993) (64)
Low- and high-level transgenic expression of beta2-adrenergic receptors differentially affect cardiac hypertrophy and function in Galphaq-overexpressing mice. (1999) (63)
α2A- and α2C-Adrenergic Receptors Form Homo- and Heterodimers: The Heterodimeric State Impairs Agonist-Promoted GRK Phosphorylation and β-Arrestin Recruitment† (2006) (61)
Regulation of responsiveness at D2 dopamine receptors by receptor desensitization and adenylyl cyclase sensitization. (1991) (61)
Lack of beta 3-adrenergic receptor mRNA expression in adipose and other metabolic tissues in the adult human. (1993) (61)
Taste and smell GPCRs in the lung: Evidence for a previously unrecognized widespread chemosensory system. (2018) (60)
Molecular and genetic basis of 2 -adrenergic receptor function (1999) (58)
beta(2)-adrenergic receptor pharmacogenetics. (2000) (57)
Transgenic replacement of type V adenylyl cyclase identifies a critical mechanism of β‐adrenergic receptor dysfunction in the Gαq overexpressing mouse (1999) (57)
Polymorphisms of the beta2-adrenergic receptor and asthma. (1997) (56)
Polymorphisms of the beta(2)-adrenergic receptor determine exercise capacity in patients with heart failure. (2000) (56)
Direct relationship between mononuclear leukocyte and lung beta-adrenergic receptors and apparent reciprocal regulation of extravascular, but not intravascular, alpha- and beta-adrenergic receptors by the sympathochromaffin system in humans. (1988) (56)
Identification and Characterization of a Homogeneous Population of β2-Adrenergic Receptors on Human Alveolar Macrophages (1989) (56)
G protein receptor kinase 4 polymorphisms: &bgr;-Blocker Pharmacogenetics and treatment-related outcomes in Hypertension (2012) (55)
Agonist-promoted homologous desensitization of human airway smooth muscle bitter taste receptors. (2011) (54)
A polymorphism of G-protein coupled receptor kinase5 alters agonist-promoted desensitization of beta2-adrenergic receptors. (2008) (54)
Polymorphisms of cardiac presynaptic alpha2C adrenergic receptors: Diverse intragenic variability with haplotype-specific functional effects. (2004) (53)
Combinatorial Pharmacogenetic Interactions of Bucindolol and β1, α2C Adrenergic Receptor Polymorphisms (2012) (53)
Rescue of tropomyosin-induced familial hypertrophic cardiomyopathy mice by transgenesis. (2007) (53)
Bronchodilator activity of bitter tastants in human tissue (2011) (52)
Phosphorylation and functional desensitization of the alpha2A-adrenergic receptor by protein kinase C. (1998) (52)
A Primate-dominant Third Glycosylation Site of the β2-Adrenergic Receptor Routes Receptors to Degradation during Agonist Regulation* (2004) (51)
Targeted transgenic expression of beta(2)-adrenergic receptors to type II cells increases alveolar fluid clearance. (2001) (51)
Beta-adrenergic receptors in the failing heart: the good, the bad, and the unknown. (2001) (50)
Identification and functional characterization of alpha(2)-adrenoceptor polymorphisms. (2001) (50)
Receptor Genotypes on Signal Transduction in Human Airway Smooth Muscle Cells (1995) (49)
An Ile to Met polymorphism in the catalytic domain of adenylyl cyclase type 9 confers reduced beta2-adrenergic receptor stimulation. (2003) (49)
Prevention of atrial fibrillation by bucindolol is dependent on the beta₁389 Arg/Gly adrenergic receptor polymorphism. (2013) (48)
Human lung cell beta 2-adrenergic receptors desensitize in response to in vivo administered beta-agonist. (1995) (48)
Regulatory haplotypes in ARG1 are associated with altered bronchodilator response. (2011) (48)
Two kinases mediate agonist-dependent phosphorylation and desensitization of the beta 2-adrenergic receptor. (1990) (47)
Identification of adrenergic receptor polymorphisms. (2002) (47)
An acidic motif within the third intracellular loop of the alpha2C2 adrenergic receptor is required for agonist-promoted phosphorylation and desensitization. (1995) (46)
Complex haplotypes derived from noncoding polymorphisms of the intronless alpha2A-adrenergic gene diversify receptor expression. (2006) (46)
An inflammation-independent contraction mechanophenotype of airway smooth muscle in asthma. (2016) (45)
MicroRNA let-7 establishes expression of β2-adrenergic receptors and dynamically down-regulates agonist-promoted down-regulation (2011) (45)
Mechanisms of Pharmacogenomic Effects of Genetic Variation within the Cardiac Adrenergic Network in Heart Failure (2009) (45)
The Ile164 beta(2)-adrenoceptor polymorphism alters salmeterol exosite binding and conventional agonist coupling to G(s). (2001) (44)
Hierarchy of polymorphic variation and desensitization permutations relative to beta 1- and beta 2-adrenergic receptor signaling. (2003) (44)
beta-Adrenergic regulation of cAMP and protein phosphorylation in phospholamban-knockout mouse hearts. (1997) (44)
Beta2-Agonist Induced Camp Is Decreased In Asthmatic Airway Smooth Muscle Due To Increased PDE4D (2011) (43)
Polymorphisms of the beta2-adrenergic receptor. (2002) (41)
Molecular mechanisms of beta2-adrenergic receptor function and regulation. (2005) (41)
Antithetic regulation by beta-adrenergic receptors of Gq receptor signaling via phospholipase C underlies the airway beta-agonist paradox. (2003) (41)
Common ADRB2 Haplotypes Derived from 26 Polymorphic Sites Direct β2-Adrenergic Receptor Expression and Regulation Phenotypes (2010) (40)
Bitter taste receptors on airway smooth muscle as targets for novel bronchodilators (2013) (40)
The Presence of Lys27 Instead of Asn27 in Human Phospholamban Promotes Sarcoplasmic Reticulum Ca2+-ATPase Superinhibition and Cardiac Remodeling (2006) (40)
Targeted transgenesis reveals discrete attenuator functions of GRK and PKA in airway β2-adrenergic receptor physiologic signaling (2009) (40)
Pharmacology and molecular biology of adrenergic receptors. (1993) (39)
Pleiotropic Effects of Bitter Taste Receptors on [Ca2+]i Mobilization, Hyperpolarization, and Relaxation of Human Airway Smooth Muscle Cells (2015) (39)
Coupling of Airway Smooth Muscle Bitter Taste Receptors to Intracellular Signaling and Relaxation Is via G&agr;i1,2,3 (2017) (39)
Race, common genetic variation, and therapeutic response disparities in heart failure. (2014) (39)
Future Translational Applications From the Contemporary Genomics Era: A Scientific Statement From the American Heart Association (2015) (39)
Direct muscarinic cholinergic inhibition of hepatic glucose production in humans. (1988) (38)
Transgenic overexpression of beta(2)-adrenergic receptors in airway epithelial cells decreases bronchoconstriction. (2000) (38)
Alpha2A- and alpha2C-adrenergic receptors form homo- and heterodimers: the heterodimeric state impairs agonist-promoted GRK phosphorylation and beta-arrestin recruitment. (2006) (38)
Phosphorylation and Desensitization of the Human -Adrenergic Receptor (1995) (37)
Genetics of β2‐adrenergic receptor variants in asthma (1995) (37)
Myocardial beta1-adrenergic receptor polymorphisms affect functional recovery after ischemic injury. (2006) (37)
Genetically modified mouse models for pharmacogenomic research (2004) (35)
Hypertrophy‐Associated Polymorphisms Ascertained in a Founder Cohort Applied to Heart Failure Risk and Mortality (2011) (35)
Modification of the β2-Adrenergic Receptor to Engineer a Receptor-Effector Complex for Gene Therapy* (2001) (35)
Synergistic polymorphisms of the β1- and α2c-adrenergic receptors and the risk of congestive heart failure ☆ (2003) (34)
Functional Receptor Coupling to Gi Is A Mechanism of Agonist-Promoted Desensitization of the β2-Adrenergic Receptor (2000) (34)
A polymorphism in the thyroid hormone receptor gene is associated with bronchodilator response in asthmatics (2011) (33)
Implications of genetic variability of human beta 2-adrenergic receptor structure. (1995) (33)
Agonist-mediated downregulation of G alpha i via the alpha 2-adrenergic receptor is targeted by receptor-Gi interaction and is independent of receptor signaling and regulation. (1998) (32)
Polymorphisms of adrenergic receptors: variations on a theme. (2003) (31)
Chimeric mutagenesis of putative G-protein coupling domains of the alpha2A-adrenergic receptor. Localization of two redundant and fully competent gi coupling domains. (1996) (31)
Adrenergic Receptor Polymorphisms and Prevention of Ventricular Arrhythmias With Bucindolol in Patients With Chronic Heart Failure (2013) (30)
Functional Properties of Human b2-Adrenergic Receptor Polymorphisms (1995) (30)
Inhibition of PI3K promotes dilation of human small airways in a rho kinase‐dependent manner (2016) (29)
The Ile 164 b 2-Adrenergic Receptor Polymorphism Adversely Affects the Outcome of Congestive Heart Failure (1998) (29)
Genetic variation, β-blockers, and perioperative myocardial infarction. (2011) (28)
Gene and Protein Domain-Specific Patterns of Genetic Variability Within the G-Protein Coupled Receptor Superfamily (2003) (28)
Identification of a Gs Coupling Domain in the Amino Terminus of the Third Intracellular Loop of the α2A-Adrenergic Receptor (1995) (28)
The pharmacogenetics of asthma: a candidate gene approach (2001) (26)
Transcriptional response to persistent beta2-adrenergic receptor signaling reveals regulation of phospholamban, which alters airway contractility. (2006) (26)
α2A/α2C-Adrenergic Receptor Third Loop Chimera Show That Agonist Interaction with Receptor Subtype Backbone Establishes G Protein-coupled Receptor Kinase Phosphorylation* (2000) (26)
False positive non‐synonymous polymorphisms of G‐protein coupled receptor genes (2002) (25)
Polymorphisms of β-adrenergic receptors in heart failure (2004) (25)
Desensitization of the beta-adrenergic receptor: distinct molecular determinants of phosphorylation by specific kinases. (1991) (25)
Yohimbine Dimers Exhibiting Selectivity for the Human α2c-Adrenoceptor Subtype (2002) (25)
A Genome-Wide Association Study of Idiopathic Dilated Cardiomyopathy in African Americans (2018) (24)
Role of the amino terminus of the third intracellular loop in agonist-promoted downregulation of the alpha2A-adrenergic receptor. (1997) (24)
A functional polymorphism of the Galphaq (GNAQ) gene is associated with accelerated mortality in African-American heart failure. (2007) (23)
Molecular and genetic basis of beta2-adrenergic receptor function. (1999) (23)
Pharmacogenomics of β‐Adrenergic Receptors and Their Accessory Signaling Proteins in Heart Failure (2008) (23)
β-Arrestin2 oligomers impair the clearance of pathological tau and increase tau aggregates (2020) (23)
Activity of the uptake-1 norepinephrine transporter as measured by I-123 MIBG in heart failure patients with a loss-of-function polymorphism of the presynaptic α2C-adrenergic receptor (2003) (22)
Perspectives of the Breast Cancer Survivorship Continuum: Diagnosis through 30 Months Post-Treatment (2015) (22)
Genetic Variation Within the β1-Adrenergic Receptor Gene Results in Haplotype-Specific Expression Phenotypes (2008) (22)
Reply to: Activation of BK channels may not be required for bitter tastant–induced bronchodilation (2012) (22)
Pharmacogenomics of beta1-adrenergic receptor polymorphisms in heart failure. (2010) (22)
Receptor-specific functional properties of beta 2-adrenergic receptor autoantibodies in asthma. (1995) (22)
Striated muscle tropomyosin isoforms differentially regulate cardiac performance and myofilament calcium sensitivity (2010) (22)
Multiple interactions between the alpha2C- and beta1-adrenergic receptors influence heart failure survival (2008) (21)
Fusion of beta 2-adrenergic receptor to G alpha s in mammalian cells: identification of a specific signal transduction species not characteristic of constitutive activation or precoupling. (2000) (20)
Beta-adrenoceptor-effector system of the human macrophage U937 cell line. (1989) (20)
Substitution of an extracellular cysteine in the beta 2-adrenergic receptor enhances agonist-promoted phosphorylation and receptor desensitization. (1989) (20)
Transgenic replacement of type V adenylyl cyclase identifies a critical mechanism of beta-adrenergic receptor dysfunction in the G alpha q overexpressing mouse. (1999) (20)
Full-genome sequence and analysis of a novel human rhinovirus strain within a divergent HRV-A clade (2009) (20)
A microphysiological model of the bronchial airways reveals the interplay of mechanical and biochemical signals in bronchospasm (2019) (20)
Temporal analysis of mRNA and miRNA expression in transgenic mice overexpressing Arg- and Gly389 polymorphic variants of the β1-adrenergic receptor. (2011) (19)
Pleiotropic beta-agonist-promoted receptor conformations and signals independent of intrinsic activity. (2007) (19)
The two-timing thyroid (2004) (19)
α2A-Adrenergic Receptors in the Genetics, Pathogenesis, and Treatment of Type 2 Diabetes (2009) (19)
Role of βARK in Long-Term Agonist-Promoted Desensitisation of the β2-Adrenergic Receptor (1998) (19)
Beta2-adrenergic receptor polymorphisms and sudden cardiac death: a signal to follow. (2006) (19)
β2-Adrenergic Receptors Chaperone Trapped Bitter Taste Receptor 14 to the Cell Surface as a Heterodimer and Exert Unidirectional Desensitization of Taste Receptor Function* (2016) (19)
Multiple potential regulatory elements in the 5' flanking region of the beta 3-adrenergic receptor. (1991) (18)
Variable-length poly-C tract polymorphisms of the beta2-adrenergic receptor 3'-UTR alter expression and agonist regulation. (2008) (18)
Coding block and 5 leader cistron polymorphisms of the beta2-adrenergic receptor. (1999) (17)
Activated cofilin exacerbates tau pathology by impairing tau-mediated microtubule dynamics (2019) (17)
Yohimbine dimers exhibiting selectivity for the human alpha 2C-adrenoceptor subtype. (2002) (17)
Biased TAS2R Bronchodilators Inhibit Airway Smooth Muscle Growth by Downregulating Phosphorylated Extracellular Signal‐regulated Kinase 1/2 (2019) (16)
Genetic variability of the β2 adrenergic receptor and asthma exacerbations (2006) (16)
Heterogeneity in beta-adrenergic receptor kinase expression in the lung accounts for cell-specific desensitization of the beta2-adrenergic receptor. (1997) (16)
Identification and characterization of a homogeneous population of beta 2-adrenergic receptors on human alveolar macrophages. (1989) (16)
Functional Genomics of Lung Disease (2004) (15)
Activated cofilin exacerbates tau pathology by impairing tau-mediated microtubule dynamics (2019) (15)
Human tissue adrenergic receptors are not predictive of responses to epinephrine in vivo. (1989) (14)
Bitter taste receptors in the wrong place: novel airway smooth muscle targets for treating asthma. (2014) (14)
Functional alpha 2-adrenergic receptor-Gs coupling undergoes agonist-promoted desensitization in a subtype-selective manner. (1993) (14)
Genetics of beta 2-adrenergic receptor variants in asthma. (1995) (13)
Differential coupling of Arg- and Gly389 polymorphic forms of the beta1-adrenergic receptor leads to pathogenic cardiac gene regulatory programs. (2008) (13)
Phosphorylation of Ser360 in the third intracellular loop of the alpha2A-adrenoceptor during protein kinase C-mediated desensitization. (2002) (13)
An internal domain of beta-tropomyosin increases myofilament Ca(2+) sensitivity. (2009) (12)
Medetomidine analogs as selective agonists for the human α2-adrenoceptors (2004) (12)
Serine 232 of the alpha(2A)-adrenergic receptor is a protein kinase C-sensitive effector coupling switch. (2001) (12)
Allele-specific binding of airway nuclear extracts to polymorphic beta2-adrenergic receptor 5' sequence. (2007) (12)
Tropomyosin pseudo-phosphorylation results in dilated cardiomyopathy (2018) (12)
Cardiac 7-transmembrane-spanning domain receptor portfolios: diversify, diversify, diversify. (2006) (11)
A CREB‐mediated increase in miRNA let‐7f during prolonged β‐agonist exposure: a novel mechanism of β2‐adrenergic receptor down‐regulation in airway smooth muscle (2018) (11)
Paradoxical attenuation of β2-AR function in airway smooth muscle by Gi-mediated counterregulation in transgenic mice overexpressing type 5 adenylyl cyclase. (2011) (11)
Biased TAS2R Bronchodilators Inhibit Airway Smooth Muscle Growth by Downregulating pERK1/2 (2019) (10)
Electrical pacing induces adenylyl cyclase in skeletal muscle independent of the beta-adrenergic receptor. (1992) (10)
Heterogeneity of transcription factor expression and regulation in human airway epithelial and smooth muscle cells. (2007) (10)
Update on current concepts of the basis of β2-adrenergic receptor signaling (2002) (9)
Subcellular distribution of beta 2-adrenergic receptors delineated with quantitative ultrastructural autoradiography of radioligand binding sites. (1992) (9)
Pepducins as a potential treatment strategy for asthma and COPD. (2018) (9)
Structural determinants of alpha 2-adrenergic receptor regulation. (1998) (8)
Bitransgenesis with β2‐Adrenergic Receptors or Adenylyl Cyclase Fails to Improve β1‐Adrenergic Receptor Cardiomyopathy (2008) (8)
Hearts : Critical Role for Expression Level-Adrenergic Receptor Overexpression in Mouse 2 β Early and Delayed Consequences of Print (2000) (8)
Polymorphisms in human heat shock factor-1 and analysis of potential biological consequences (2014) (7)
Polymorphisms of the b 2 -Adrenergic Receptor Determine Exercise Capacity in Patients With Heart Failure (2000) (7)
Differential long‐term regulation of TAS2R14 by structurally distinct agonists (2019) (7)
Identification and characterization of an atypical Gαs-biased β2AR agonist that fails to evoke airway smooth muscle cell tachyphylaxis (2021) (6)
Polymorphisms of beta-adrenergic receptors in heart failure. (2004) (6)
Pharmacogenetics of beta1-adrenergic receptors in heart failure and hypertension. (2006) (6)
The odorant receptor OR2W3 on airway smooth muscle evokes bronchodilation via a cooperative chemosensory tradeoff between TMEM16A and CFTR (2020) (6)
Targeted transgenesis identifies Gαs as the bottleneck in β2-adrenergic receptor cell signaling and physiological function in airway smooth muscle. (2014) (6)
Genetic, Molecular, and Clinical Characterization of Adrenergic Receptor Polymorphisms (2006) (5)
Medetomidine analogs as selective agonists for the human alpha2-adrenoceptors. (2004) (5)
Genome Sequences of Rhinovirus C Isolates from Wisconsin Pediatric Respiratory Studies (2014) (5)
Long-distance affair with adrenal GRK2 hangs up heart failure (2007) (5)
Genome Sequences of Rhinovirus A Isolates from Wisconsin Pediatric Respiratory Studies (2014) (5)
β-arrestin1 promotes tauopathy by transducing GPCR signaling, disrupting microtubules and autophagy (2021) (5)
Racial differences in the frequencies of cardiac β1-adrenergic receptor polymorphisms: Analysis of c145A>G and c1165G>C Communicated by: R.G.H. Cotton Online Citation: Human Mutation, Mutation and Polymorphism Report #65 (1999) Online http://journals.wiley.com/1059-7794/pdf/mutation/mpr65.pdf (1999) (4)
Identification and Characterization of Novel Bronchodilator Agonists Acting at Human Airway Smooth Muscle Cell TAS2R5. (2020) (4)
α1B/D-adrenoceptors regulate chemokine receptor–mediated leukocyte migration via formation of heteromeric receptor complexes (2022) (4)
Biased β-Agonists Favoring Gs over β-Arrestin for Individualized Treatment of Obstructive Lung Disease (2022) (4)
Cardiomyopathy Induced −-Adrenergic β Common Genomic Response in Different Mouse Models of Print (2003) (4)
Dose Response of &bgr;-Blockers in Adrenergic Receptor Polymorphism Genotypes (2018) (4)
Cerebrospinal fluid xanthochromia with rifampin (1982) (4)
G-protein coupled receptors, nitric oxide, and the IgE receptor in asthma. (1995) (4)
Plastic adenylyl cyclase. (1999) (4)
Role of beta ARK in long-term agonist-promoted desensitisation of the beta 2-adrenergic receptor. (1998) (3)
Hypoglycemia in the Critically Ill Patient (1986) (3)
Genome Sequences of Rhinovirus B Isolates from Wisconsin Pediatric Respiratory Studies (2014) (3)
Lymphocyte GRK levels as biomarkers in heart failure. (2005) (3)
G PROTEIN RECEPTOR KINASE 4 ( GRK 4 ) POLYMORPHISMS : BETA-BLOCKER PHARMACOGENETICS AND TREATMENT RELATED OUTCOMES IN HYPERTENSION (3)
Structures and Agonist Binding Sites of Bitter Taste Receptor TAS2R5 Complexed with Gi Protein and Validated against Experiment. (2021) (3)
Development of a Rhinovirus Inoculum Using a Reverse Genetics Approach (2018) (3)
Rhinovirus C15 Induces Airway Hyperresponsiveness Via Calcium Mobilization in Airway Smooth Muscle. (2020) (3)
Antithetic regulation by b-adrenergic receptors of G q receptor signaling via phospholipase C underlies the airway b-agonist paradox (2018) (3)
Role of the beta-adrenergic receptor kinase in desensitization of the alpha 2-adrenergic receptor. (1991) (2)
G-PROTEIN-COUPLED RECEPTORS (2006) (2)
Erratum: The effect of polymorphisms of the beta(2)-adrenergic receptor on the response to regular use of albuterol in asthma (International Archives of Allergy and Immunology (2000) 162 (75-80)) (2012) (2)
Ischemic Cardiomyopathy Response to Bucindolol May Be Differentially Influenced by b1 389 Arg/Gly and a2c Genotypes (2008) (2)
Genetic Vulnerability of GPCRs: A Call to Action. (2018) (2)
Different Patterns of LVEF/Remodeling and Clinical Endpoint Effects for Bucindolol in b1-AR 389 Arg/Gly Genotypes (2008) (2)
An internal domain of -tropomyosin increases myofilament Ca sensitivity (2009) (2)
Adrenergic receptor polymorphisms in heart failure: molecular and physiological phenotypes (2005) (2)
Adrenergic receptors are a fallible index of adrenergic denervation hypersensitivity. (1991) (2)
A microphysiological model of the bronchial airways reveals the interplay of mechanical and biochemical signals in bronchospasm (2019) (1)
Peripheral Blood Gene Expression Changes Predict Mortality and Treatment Response in Acute Covid-19 and Associate with Lung Fibrosis (2022) (1)
Propylhexedrine Intoxication: Clinical Presentation and Pharmacology. (1982) (1)
Regulatory Haplotypes In ARG1 Are Associated With Bronchodilator Response (2010) (1)
Abstract 2001: Genetic {beta}-Blockade: A G-Protein Coupled Receptor Kinase-5 Polymorphism That Inhibits Beta-Adrenergic Receptor Signaling is Protective in Heart Failure (2006) (1)
Determination of Hospitalization Type by Investigator Case Report Form or Adjudication Committee in a Large Heart Failure Clinical Trial (BEST) (2008) (1)
Structural basis for receptor subtype-specific regulation revealed by a chimeric 83 / j 82-adrenergic receptor ( desensitization / phosphorylatlon / down-regulation / adenylyl cyclase ) (1)
Histamine N‐methyltransferase (HNMT) pharmacogenetics: Association of the C314T genetic polymorphism with allergic asthma (1999) (1)
A Par3/LIM Kinase/Cofilin Pathway Mediates Human Airway Smooth Muscle Relaxation by TAS2R14. (2023) (1)
Rapid Communication Subcellular Distribution of 32-Adrenergic Receptors Delineated With Quantitative Ultrastructural Autoradiography of Radioligand Binding Sites (2005) (1)
(cid:1) 2 -Adrenergic Receptor Polymorphisms and Sudden Cardiac Death A Signal to Follow (2006) (1)
Detailed sequence and haplotype analysis of the beta-2 adrenergic receptor gene in Caucasians and African Americans (2005) (1)
Failure of pressure overload hypertrophy in Gαq overexpressing mice (1998) (1)
Polymorphisms of heat shock factor‐1: Genetic diversity in an evolutionarily conserved, multifunctional regulator gene (2011) (1)
Abstract 754: Expression Analysis and Functional Significance of a Novel Cardiac Specific Human Tropomyosin in Normal and Cardiomyopathy Patients (2007) (1)
Upregulation Of Bitter Taste Receptor Cell Surface Expression By Chronic Agonist: A Novel Trafficking Outcome That May Minimize Tachyphylaxis (2012) (1)
A Novel Photo-electrochemical Oxidation Air-Purification Technology Reduces Asthma Symptoms (2018) (0)
Role of cofilin in tau/microtubule dynamics and tauopathy (2019) (0)
Differential Effects of β-1 Polymorphisms on Mortality, Hospitalizations, and Myocardial Infarctions with Bucindolol Therapy (2006) (0)
The Relaxation Effect of Pitavastatin on Human Airway Smooth Muscle Cells: A Role for Acute F-actin Disruption (2023) (0)
R treatment with bucindolol (2005) (0)
Death‐associated protein kinase mediates myofibril degeneration and myocyte apoptosis induced by beta‐adrenergic receptors (404.3) (2014) (0)
Potato Crisp moisture determination using NIR data and a Back Propagation Neural Network (2013) (0)
transgenic mice overexpressing type 5 adenylyl cyclase -mediated counterregulation in i smooth muscle by G -AR function in airway (2016) (0)
Procedures for risk assessment, survival prediction and treatment of heart failure and other suffering on the basis of polymorphisms of adrenergic receptors (2004) (0)
Evolution and structure of human rhinoviruses as determined from full genome sequences (2010) (0)
Non-genetic Insights Into the Functional Efficacy of β2-adrenoreceptors in Human Airway Smooth Muscle Cells Through the Lens of Bitter Taste Receptors (2023) (0)
Pharmacogenetics of Respiratory Disease (2016) (0)
Report of the Working Group on functional genetics/molecular approaches to asthma genetics (1998) (0)
P431 Novel photo-electrochemical oxidation air-purifiication technology reduces nasal and ocular allergy symptoms (2017) (0)
Bitter Taste Receptor Signaling On Airway Smooth Muscle: A Highly Efficacious Pathway For Treating Obstructive Airway Disease (2011) (0)
Pharmacogenomics of b 1 -Adrenergic Receptor Polymorphisms in Hear t Failure (2010) (0)
β-ADRENERGIC RECEPTOR DESENSITIZATION DURING CARDIOPULMONARY BYPASS (1991) (0)
Ongoing Promises and Public Expectations of the HGP (0)
β‐arrestin2 oligomers impair the clearance of pathological tau and increase tau aggregates (2020) (0)
Polymorphisms Of Heat Shock Factor-1: Genetic Diversity With The Prospect Of Functional Variability Relevant To Heat Shock And Inflammation (2011) (0)
Regulation of Intracellular Calcium by Bitter Taste Receptors on Airway Smooth Muscle (2014) (0)
TAS 2 R Activation Promotes Airway Smooth Muscle Relaxation Despite β 2-Adrenergic 1 Receptor Tachyphylaxis 2 3 (2012) (0)
Past Successes of Genetic Findings Familial Hypercholesterolemia and Low-Density Lipoprotein Cholesterol Lowering (2015) (0)
β-Adrenergic Receptors (2004) (0)
Chapter 45 – Adrenergic Receptor Polymorphisms in Heart Failure (2012) (0)
Tight control of adrenal medulla catecholamine release by alpha 2C-adrenergic receptors influences susceptibility to heart failure. (2007) (0)
Abstract 398: Pharmacogenetic Therapeutic Enhancement of a Prespecified Composite Morbidity-Mortality Measurement in BEST (2006) (0)
Bitter Taste Receptors and Bronchodilation (2016) (0)
The Ile164 β2-adrenergic receptor polymorphism is associated with decreased exercise capacity in patients with heart failure (1999) (0)
Whole Transcriptome Analysis Of Mutated ²2-Adrenergic Receptors Reveals "Ancillary Pathways" Attributable To Receptor Phosphorylation By GRKs And PKA (2012) (0)
Abstract 2177: Differential Effects of {beta}-1 Polymorphisms on Mortality, Hospitalizations, and Myocardial Infarctions with Bucindolol Therapy. (2006) (0)
MECHANISMS OF DYSFUNCTIONAL BETA 2-ADRENERGIC SIGNALING IN FATAL ASTHMA (1998) (0)
Clinical and molecular implications of RGS2 promoter genetic variation in severe asthma (2022) (0)
Receptor Affect Agonist-Promoted Trafficking (2002) (0)
Selective Signal Capture from Multidimensional GPCR Outputs with Biased Agonists: Progress Towards Novel Drug Development (2022) (0)
The short third intracellular loop and cytoplasmic tail of bitter taste receptors provide functionally relevant GRK phosphorylation sites in TAS2R14 (2021) (0)
Association d'haplotypes du recepteur adrenergique beta2 reagissant aux medicaments (2000) (0)
Hereditary dysautonomias: current knowledge and collaborations for the future (2003) (0)
Epigenetics Of The ²2-Adrenergic Receptor Gene (2010) (0)
Abstract 2912: Effect of {beta}1 389 Arg/Gly {alpha}2c 322 325 Wt/Del Genotypes on Adjudicated Hospitalizations in the BEST Trial (2007) (0)
An Internal Domain of Beta Tropomyosin Increases Myofilament Calcium Sensitivity (2009) (0)
' s personal copy Pharmacogenomics of b 1-Adrenergic Receptor Polymorphisms in Heart Failure (2009) (0)
Polymorphisms of theb2-Adrenergic Receptor Determine Exercise Capacity in Patients With Heart Failure (2000) (0)
Enhanced Ca2+ transient and cell contractility is associated with decreased Cx43 in β1-ARG389 mice (2007) (0)
WITHDRAWN: Enhanced Ca2+ transient & cell contractility is associated with decreased Cx43 in β1-ARG389 mice (2007) (0)
Title Inhibition of PI 3 K promotes dilation of human small airways in a rho kinase-dependent manner (2016) (0)
Bitter Taste Receptors And β2-Adrenergic Receptors Mediate Relaxation Of Airway Smooth Muscle In An Additive Manner (2012) (0)
Preface to Special Issue on ‘Cytochrome P450 Variation in Pharmacogenomics’ (2018) (0)
Deep Resequencing of the Beta-2 Adrenergic Receptor Gene (ADRB2) in COPD and Asthma Cohorts Identifies Functional Rare Variants (2020) (0)
Clinical and molecular implications of RGS2 promoter genetic variation in severe asthma. (2022) (0)
Chloroquine, A TAS2R Agonist, Promotes Airway Smooth Muscle Relaxation Despite B2Adrenergic Receptor Tachyphylaxis (2012) (0)
Polymorphisms in human heat shock factor-1 and analysis of potential biological consequences (2014) (0)
G-Protein Receptor Kinase-5 Polymorphism Influences Therapeutic Efficacy of β-Blockers in Heart Failure (2006) (0)
Predicted structure and cell signaling of TAS2R14 reveal receptor hyper-flexibility for detecting diverse bitter tastes. (2023) (0)
Sequence Analysis of a Cloned Human Rhinovirus Designed For Use in Human Inoculation Studies (2012) (0)
Agonist-Promoted Desensitization Of Bitter Taste Receptors Expressed On Airway Smooth Muscle (2011) (0)
Discovery and Characterization of the First Biased Beta-Agonist That Favors Gs-Coupling vs Beta-Arrestin Mediated Desensitization: A New Class of Structurally Distinct Beta-Agonists for Treating Obstructive Lung Diseases (2022) (0)

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