Stephen B. Liggett
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Pharmacology
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Stephen B. Liggett's Degrees
- Bachelors Chemistry University of Cincinnati
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(Suggest an Edit or Addition)Stephen B. Liggett's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness. (2000) (1018)
- Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties. (1994) (805)
- Transgenic Gαq overexpression induces cardiac contractile failure in mice (1997) (621)
- Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial (2004) (618)
- Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects. (1993) (608)
- A Gain-of-function Polymorphism in a G-protein Coupling Domain of the Human β1-Adrenergic Receptor* (1999) (592)
- The effect of polymorphisms of the beta(2)-adrenergic receptor on the response to regular use of albuterol in asthma. (2000) (565)
- Enhanced Galphaq signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failure. (1998) (561)
- PKC-α regulates cardiac contractility and propensity toward heart failure (2004) (527)
- Synergistic Polymorphisms of β1- and α2C-Adrenergic Receptors and the Risk of Congestive Heart Failure (2002) (495)
- A polymorphism of the human beta 2-adrenergic receptor within the fourth transmembrane domain alters ligand binding and functional properties of the receptor. (1993) (485)
- Sequencing and Analyses of All Known Human Rhinovirus Genomes Reveal Structure and Evolution (2009) (438)
- Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human. (2003) (438)
- Influence of beta 2-adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells. (1995) (435)
- Early and delayed consequences of beta(2)-adrenergic receptor overexpression in mouse hearts: critical role for expression level. (2000) (410)
- A polymorphism within a conserved β1-adrenergic receptor motif alters cardiac function and β-blocker response in human heart failure (2006) (408)
- Genetic polymorphisms of the beta 2-adrenergic receptor in nocturnal and nonnocturnal asthma. Evidence that Gly16 correlates with the nocturnal phenotype. (1995) (399)
- β1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure (2003) (356)
- PKC-alpha regulates cardiac contractility and propensity toward heart failure. (2004) (347)
- The Ile164 beta2-adrenergic receptor polymorphism adversely affects the outcome of congestive heart failure. (1998) (345)
- A GRK5 polymorphism that inhibits β-adrenergic receptor signaling is protective in heart failure (2008) (339)
- Phosphorylation and desensitization of the human beta 1-adrenergic receptor. Involvement of G protein-coupled receptor kinases and cAMP-dependent protein kinase. (1995) (326)
- Pharmacology and physiology of human adrenergic receptor polymorphisms. (2003) (317)
- Association of Glu 27 β2-adrenoceptor polymorphism with lower airway reactivity in asthmatic subjects (1995) (313)
- Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids. (2004) (310)
- Bitter taste receptors on airway smooth muscle bronchodilate by a localized calcium flux and reverse obstruction (2010) (306)
- Simultaneous coupling of alpha 2-adrenergic receptors to two G-proteins with opposing effects. Subtype-selective coupling of alpha 2C10, alpha 2C4, and alpha 2C2 adrenergic receptors to Gi and Gs. (1992) (297)
- Polymorphisms of the 5' leader cistron of the human beta2-adrenergic receptor regulate receptor expression. (1998) (286)
- Transgenic Galphaq overexpression induces cardiac contractile failure in mice. (1997) (260)
- A polymorphism within a conserved beta(1)-adrenergic receptor motif alters cardiac function and beta-blocker response in human heart failure. (2006) (243)
- Low- and high-level transgenic expression of β2-adrenergic receptors differentially affect cardiac hypertrophy and function in Gαq-overexpressing mice (1999) (227)
- Structural basis for receptor subtype-specific regulation revealed by a chimeric beta 3/beta 2-adrenergic receptor. (1993) (220)
- beta2-Adrenergic receptor haplotypes in mild, moderate and fatal/near fatal asthma. (1998) (210)
- Amino Acid 49 Polymorphisms of the Human &bgr; 1 -Adrenergic Receptor Affect Agonist-Promoted Trafficking (2002) (197)
- Myocardial signaling defects and impaired cardiac function of a human beta 2-adrenergic receptor polymorphism expressed in transgenic mice. (1996) (191)
- Decompensation of Pressure-Overload Hypertrophy in Gαq-Overexpressing Mice (1998) (190)
- A Four Amino Acid Deletion Polymorphism in the Third Intracellular Loop of the Human α2C-Adrenergic Receptor Confers Impaired Coupling to Multiple Effectors* (2000) (182)
- Molecular modeling, organ culture and reverse genetics for a newly identified human rhinovirus C (2011) (180)
- Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure. (2002) (173)
- Sequence, haplotype, and association analysis of ADRbeta2 in a multiethnic asthma case-control study. (2006) (168)
- The glutamine 27 beta2-adrenoceptor polymorphism is associated with elevated IgE levels in asthmatic families. (1997) (167)
- Polymorphisms of the β2-Adrenergic Receptor Determine Exercise Capacity in Patients With Heart Failure (2000) (164)
- Sustained Activation of a G Protein-coupled Receptor via “Anchored” Agonist Binding (1996) (162)
- Polymorphisms of the β2-Adrenergic Receptor and Asthma (1997) (158)
- Polymorphic Deletion of Three Intracellular Acidic Residues of the α2B-Adrenergic Receptor Decreases G Protein-coupled Receptor Kinase-mediated Phosphorylation and Desensitization* (2001) (152)
- Pharmacogenetics of Beta-1- and Beta-2-Adrenergic Receptors (2000) (145)
- The alpha 1C-adrenergic receptor: characterization of signal transduction pathways and mammalian tissue heterogeneity. (1991) (144)
- Contribution of ligand structure to activation of alpha 2-adrenergic receptor subtype coupling to Gs. (1994) (144)
- Lack of association between adrenergic receptor genotypes and survival in heart failure patients treated with carvedilol or metoprolol. (2008) (139)
- Airway smooth muscle prostaglandin-EP1 receptors directly modulate beta2-adrenergic receptors within a unique heterodimeric complex. (2006) (133)
- Polymorphisms of the beta1-adrenergic receptor predict exercise capacity in heart failure. (2002) (133)
- beta2-adrenergic receptor polymorphisms at amino acid 16 differentially influence agonist-stimulated blood pressure and peripheral blood flow in normal individuals. (2000) (133)
- Protein Kinase C&agr; Negatively Regulates Systolic and Diastolic Function in Pathological Hypertrophy (2003) (133)
- Phosphorylation Barcoding as a Mechanism of Directing GPCR Signaling (2011) (128)
- β2-Adrenergic Receptor Pharmacogenetics (2000) (124)
- Antithetic regulation by β-adrenergic receptors of Gq receptor signaling via phospholipase C underlies the airway β-agonist paradox (2003) (122)
- Long-term agonist exposure induces upregulation of beta 3-adrenergic receptor expression via multiple cAMP response elements. (1992) (122)
- Subtype-selective desensitization of alpha 2-adrenergic receptors. Different mechanisms control short and long term agonist-promoted desensitization of alpha 2C10, alpha 2C4, and alpha 2C2. (1992) (120)
- Desensitization of Myocardial β‐Adrenergic Receptors During Cardiopulmonary Bypass: Evidence for Early Uncoupling and Late Downregulation (1991) (117)
- Four Consecutive Serines in the Third Intracellular Loop Are the Sites for β-Adrenergic Receptor Kinase-mediated Phosphorylation and Desensitization of the α2A-Adrenergic Receptor (*) (1995) (117)
- Beta 1- and beta 2-adrenergic receptors display subtype-selective coupling to Gs. (1992) (116)
- ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts. (2008) (114)
- Effect of Polymorphism of the β2-Adrenergic Receptor on Response to Regular Use of Albuterol in Asthma (2001) (113)
- Interactions Between Phospholamban and &bgr;-Adrenergic Drive May Lead to Cardiomyopathy and Early Mortality (2001) (113)
- Coupling of a mutated form of the human beta 2-adrenergic receptor to Gi and Gs. Requirement for multiple cytoplasmic domains in the coupling process. (1991) (112)
- The pharmacogenetics of beta2-adrenergic receptors: relevance to asthma. (2000) (112)
- Functional properties of the rat and human beta 3-adrenergic receptors: differential agonist activation of recombinant receptors in Chinese hamster ovary cells. (1992) (111)
- Extraoral bitter taste receptors as mediators of off‐target drug effects (2012) (111)
- Analysis of the complete genome sequences of human rhinovirus. (2010) (109)
- Cardiac Specific Overexpression of Transglutaminase II (Gh) Results in a Unique Hypertrophy Phenotype Independent of Phospholipase C Activation* (1999) (108)
- Sites in the third intracellular loop of the alpha 2A-adrenergic receptor confer short term agonist-promoted desensitization. Evidence for a receptor kinase-mediated mechanism. (1992) (107)
- Racial differences in the frequencies of cardiac β1‐adrenergic receptor polymorphisms: Analysis of c145A>G and c1165G>C (1999) (106)
- A proline-rich region of the third intracellular loop imparts phenotypic beta 1-versus beta 2-adrenergic receptor coupling and sequestration. (1994) (105)
- Effects of thyroid hormone on cardiac beta-adrenergic responsiveness in conscious baboons. (1997) (105)
- Identification of a Gs coupling domain in the amino terminus of the third intracellular loop of the alpha 2A-adrenergic receptor. Evidence for distinct structural determinants that confer Gs versus Gi coupling. (1995) (103)
- Molecular properties and pharmacogenetics of a polymorphism of adenylyl cyclase type 9 in asthma: interaction between beta-agonist and corticosteroid pathways. (2005) (101)
- Dilated Cardiomyopathy Mutant Tropomyosin Mice Develop Cardiac Dysfunction With Significantly Decreased Fractional Shortening and Myofilament Calcium Sensitivity (2007) (101)
- Histamine N-methyltransferase pharmacogenetics: association of a common functional polymorphism with asthma. (2000) (97)
- Heterogeneity in β-Adrenergic Receptor Kinase Expression in the Lung Accounts for Cell-specific Desensitization of the β2-Adrenergic Receptor* (1997) (92)
- Implications of Genetic Variability of Human β2-adrenergic Receptor Structure (1995) (91)
- Overview of the pharmacogenetics of asthma treatment (2006) (90)
- Pharmacogenetic applications of the Human Genome project (2001) (89)
- An &agr;2C-Adrenergic Receptor Polymorphism Alters the Norepinephrine-Lowering Effects and Therapeutic Response of the &bgr;-Blocker Bucindolol in Chronic Heart Failure (2010) (88)
- Mechanisms of impaired beta-adrenergic receptor signaling in G(alphaq)-mediated cardiac hypertrophy and ventricular dysfunction. (2000) (87)
- The Ile164 β2-adrenoceptor polymorphism alters salmeterol exosite binding and conventional agonist coupling to Gs (2001) (85)
- Increased fat and skeletal muscle beta-adrenergic receptors but unaltered metabolic and hemodynamic sensitivity to epinephrine in vivo in experimental human thyrotoxicosis. (1989) (83)
- Alpha 2A-adrenergic receptor stimulated calcium release is transduced by Gi-associated G(beta gamma)-mediated activation of phospholipase C. (1997) (83)
- Molecular and Functional Characterization of a Novel Cardiac-Specific Human Tropomyosin Isoform (2009) (83)
- TAS2R activation promotes airway smooth muscle relaxation despite β(2)-adrenergic receptor tachyphylaxis. (2012) (82)
- β2-Agonist Induced cAMP Is Decreased in Asthmatic Airway Smooth Muscle Due to Increased PDE4D (2011) (81)
- The palmitoylated cysteine of the cytoplasmic tail of alpha 2A-adrenergic receptors confers subtype-specific agonist-promoted downregulation. (1994) (79)
- G Protein-coupled Receptor Kinase Specificity for Phosphorylation and Desensitization of α2-Adrenergic Receptor Subtypes* (1996) (79)
- Defining an olfactory receptor function in airway smooth muscle cells (2016) (78)
- Chimeric Mutagenesis of Putative G-protein Coupling Domains of the α2A-Adrenergic Receptor (1996) (76)
- An Asn to Lys Polymorphism in the Third Intracellular Loop of the Human α2A-Adrenergic Receptor Imparts Enhanced Agonist-promoted Gi Coupling* (2000) (74)
- Decompensation of pressure-overload hypertrophy in G alpha q-overexpressing mice. (1998) (73)
- Crosstalk between Gi and Gq/Gs pathways in airway smooth muscle regulates bronchial contractility and relaxation. (2007) (73)
- Alternative splicing of the G protein-coupled receptor superfamily in human airway smooth muscle diversifies the complement of receptors (2008) (73)
- Common Genomic Response in Different Mouse Models of &bgr;-Adrenergic–Induced Cardiomyopathy (2003) (72)
- Hierarchy of Polymorphic Variation and Desensitization Permutations Relative to β1- and β2-Adrenergic Receptor Signaling* (2003) (69)
- Altered patterns of agonist-stimulated cAMP accumulation in cells expressing mutant beta 2-adrenergic receptors lacking phosphorylation sites. (1989) (68)
- Transgenic Overexpression of β2-Adrenergic Receptors in Airway Smooth Muscle Alters Myocyte Function and Ablates Bronchial Hyperreactivity* (1999) (68)
- Bitter taste receptor function in asthmatic and nonasthmatic human airway smooth muscle cells. (2014) (68)
- Update on current concepts of the molecular basis of beta2-adrenergic receptor signaling. (2002) (68)
- Molecular Mechanisms of β2-Adrenergic Receptor Function and Regulation (2005) (66)
- Altering the receptor-effector ratio by transgenic overexpression of type V adenylyl cyclase: enhanced basal catalytic activity and function without increased cardiomyocyte beta-adrenergic signalling. (1999) (66)
- Characterization of beta-adrenergic receptors of human skeletal muscle obtained by needle biopsy. (1988) (66)
- Human alpha 2-adrenergic receptor subtype distribution: widespread and subtype-selective expression of alpha 2C10, alpha 2C4, and alpha 2C2 mRNA in multiple tissues. (1993) (64)
- Low- and high-level transgenic expression of beta2-adrenergic receptors differentially affect cardiac hypertrophy and function in Galphaq-overexpressing mice. (1999) (63)
- α2A- and α2C-Adrenergic Receptors Form Homo- and Heterodimers: The Heterodimeric State Impairs Agonist-Promoted GRK Phosphorylation and β-Arrestin Recruitment† (2006) (61)
- Regulation of responsiveness at D2 dopamine receptors by receptor desensitization and adenylyl cyclase sensitization. (1991) (61)
- Lack of beta 3-adrenergic receptor mRNA expression in adipose and other metabolic tissues in the adult human. (1993) (61)
- Taste and smell GPCRs in the lung: Evidence for a previously unrecognized widespread chemosensory system. (2018) (60)
- Molecular and genetic basis of 2 -adrenergic receptor function (1999) (58)
- beta(2)-adrenergic receptor pharmacogenetics. (2000) (57)
- Transgenic replacement of type V adenylyl cyclase identifies a critical mechanism of β‐adrenergic receptor dysfunction in the Gαq overexpressing mouse (1999) (57)
- Polymorphisms of the beta2-adrenergic receptor and asthma. (1997) (56)
- Polymorphisms of the beta(2)-adrenergic receptor determine exercise capacity in patients with heart failure. (2000) (56)
- Direct relationship between mononuclear leukocyte and lung beta-adrenergic receptors and apparent reciprocal regulation of extravascular, but not intravascular, alpha- and beta-adrenergic receptors by the sympathochromaffin system in humans. (1988) (56)
- Identification and Characterization of a Homogeneous Population of β2-Adrenergic Receptors on Human Alveolar Macrophages (1989) (56)
- G protein receptor kinase 4 polymorphisms: &bgr;-Blocker Pharmacogenetics and treatment-related outcomes in Hypertension (2012) (55)
- Agonist-promoted homologous desensitization of human airway smooth muscle bitter taste receptors. (2011) (54)
- A polymorphism of G-protein coupled receptor kinase5 alters agonist-promoted desensitization of beta2-adrenergic receptors. (2008) (54)
- Polymorphisms of cardiac presynaptic alpha2C adrenergic receptors: Diverse intragenic variability with haplotype-specific functional effects. (2004) (53)
- Combinatorial Pharmacogenetic Interactions of Bucindolol and β1, α2C Adrenergic Receptor Polymorphisms (2012) (53)
- Rescue of tropomyosin-induced familial hypertrophic cardiomyopathy mice by transgenesis. (2007) (53)
- Bronchodilator activity of bitter tastants in human tissue (2011) (52)
- Phosphorylation and functional desensitization of the alpha2A-adrenergic receptor by protein kinase C. (1998) (52)
- A Primate-dominant Third Glycosylation Site of the β2-Adrenergic Receptor Routes Receptors to Degradation during Agonist Regulation* (2004) (51)
- Targeted transgenic expression of beta(2)-adrenergic receptors to type II cells increases alveolar fluid clearance. (2001) (51)
- Beta-adrenergic receptors in the failing heart: the good, the bad, and the unknown. (2001) (50)
- Identification and functional characterization of alpha(2)-adrenoceptor polymorphisms. (2001) (50)
- Receptor Genotypes on Signal Transduction in Human Airway Smooth Muscle Cells (1995) (49)
- An Ile to Met polymorphism in the catalytic domain of adenylyl cyclase type 9 confers reduced beta2-adrenergic receptor stimulation. (2003) (49)
- Prevention of atrial fibrillation by bucindolol is dependent on the beta₁389 Arg/Gly adrenergic receptor polymorphism. (2013) (48)
- Human lung cell beta 2-adrenergic receptors desensitize in response to in vivo administered beta-agonist. (1995) (48)
- Regulatory haplotypes in ARG1 are associated with altered bronchodilator response. (2011) (48)
- Two kinases mediate agonist-dependent phosphorylation and desensitization of the beta 2-adrenergic receptor. (1990) (47)
- Identification of adrenergic receptor polymorphisms. (2002) (47)
- An acidic motif within the third intracellular loop of the alpha2C2 adrenergic receptor is required for agonist-promoted phosphorylation and desensitization. (1995) (46)
- Complex haplotypes derived from noncoding polymorphisms of the intronless alpha2A-adrenergic gene diversify receptor expression. (2006) (46)
- An inflammation-independent contraction mechanophenotype of airway smooth muscle in asthma. (2016) (45)
- MicroRNA let-7 establishes expression of β2-adrenergic receptors and dynamically down-regulates agonist-promoted down-regulation (2011) (45)
- Mechanisms of Pharmacogenomic Effects of Genetic Variation within the Cardiac Adrenergic Network in Heart Failure (2009) (45)
- The Ile164 beta(2)-adrenoceptor polymorphism alters salmeterol exosite binding and conventional agonist coupling to G(s). (2001) (44)
- Hierarchy of polymorphic variation and desensitization permutations relative to beta 1- and beta 2-adrenergic receptor signaling. (2003) (44)
- beta-Adrenergic regulation of cAMP and protein phosphorylation in phospholamban-knockout mouse hearts. (1997) (44)
- Beta2-Agonist Induced Camp Is Decreased In Asthmatic Airway Smooth Muscle Due To Increased PDE4D (2011) (43)
- Polymorphisms of the beta2-adrenergic receptor. (2002) (41)
- Molecular mechanisms of beta2-adrenergic receptor function and regulation. (2005) (41)
- Antithetic regulation by beta-adrenergic receptors of Gq receptor signaling via phospholipase C underlies the airway beta-agonist paradox. (2003) (41)
- Common ADRB2 Haplotypes Derived from 26 Polymorphic Sites Direct β2-Adrenergic Receptor Expression and Regulation Phenotypes (2010) (40)
- Bitter taste receptors on airway smooth muscle as targets for novel bronchodilators (2013) (40)
- The Presence of Lys27 Instead of Asn27 in Human Phospholamban Promotes Sarcoplasmic Reticulum Ca2+-ATPase Superinhibition and Cardiac Remodeling (2006) (40)
- Targeted transgenesis reveals discrete attenuator functions of GRK and PKA in airway β2-adrenergic receptor physiologic signaling (2009) (40)
- Pharmacology and molecular biology of adrenergic receptors. (1993) (39)
- Pleiotropic Effects of Bitter Taste Receptors on [Ca2+]i Mobilization, Hyperpolarization, and Relaxation of Human Airway Smooth Muscle Cells (2015) (39)
- Coupling of Airway Smooth Muscle Bitter Taste Receptors to Intracellular Signaling and Relaxation Is via G&agr;i1,2,3 (2017) (39)
- Race, common genetic variation, and therapeutic response disparities in heart failure. (2014) (39)
- Future Translational Applications From the Contemporary Genomics Era: A Scientific Statement From the American Heart Association (2015) (39)
- Direct muscarinic cholinergic inhibition of hepatic glucose production in humans. (1988) (38)
- Transgenic overexpression of beta(2)-adrenergic receptors in airway epithelial cells decreases bronchoconstriction. (2000) (38)
- Alpha2A- and alpha2C-adrenergic receptors form homo- and heterodimers: the heterodimeric state impairs agonist-promoted GRK phosphorylation and beta-arrestin recruitment. (2006) (38)
- Phosphorylation and Desensitization of the Human -Adrenergic Receptor (1995) (37)
- Genetics of β2‐adrenergic receptor variants in asthma (1995) (37)
- Myocardial beta1-adrenergic receptor polymorphisms affect functional recovery after ischemic injury. (2006) (37)
- Genetically modified mouse models for pharmacogenomic research (2004) (35)
- Hypertrophy‐Associated Polymorphisms Ascertained in a Founder Cohort Applied to Heart Failure Risk and Mortality (2011) (35)
- Modification of the β2-Adrenergic Receptor to Engineer a Receptor-Effector Complex for Gene Therapy* (2001) (35)
- Synergistic polymorphisms of the β1- and α2c-adrenergic receptors and the risk of congestive heart failure ☆ (2003) (34)
- Functional Receptor Coupling to Gi Is A Mechanism of Agonist-Promoted Desensitization of the β2-Adrenergic Receptor (2000) (34)
- A polymorphism in the thyroid hormone receptor gene is associated with bronchodilator response in asthmatics (2011) (33)
- Implications of genetic variability of human beta 2-adrenergic receptor structure. (1995) (33)
- Agonist-mediated downregulation of G alpha i via the alpha 2-adrenergic receptor is targeted by receptor-Gi interaction and is independent of receptor signaling and regulation. (1998) (32)
- Polymorphisms of adrenergic receptors: variations on a theme. (2003) (31)
- Chimeric mutagenesis of putative G-protein coupling domains of the alpha2A-adrenergic receptor. Localization of two redundant and fully competent gi coupling domains. (1996) (31)
- Adrenergic Receptor Polymorphisms and Prevention of Ventricular Arrhythmias With Bucindolol in Patients With Chronic Heart Failure (2013) (30)
- Functional Properties of Human b2-Adrenergic Receptor Polymorphisms (1995) (30)
- Inhibition of PI3K promotes dilation of human small airways in a rho kinase‐dependent manner (2016) (29)
- The Ile 164 b 2-Adrenergic Receptor Polymorphism Adversely Affects the Outcome of Congestive Heart Failure (1998) (29)
- Genetic variation, β-blockers, and perioperative myocardial infarction. (2011) (28)
- Gene and Protein Domain-Specific Patterns of Genetic Variability Within the G-Protein Coupled Receptor Superfamily (2003) (28)
- Identification of a Gs Coupling Domain in the Amino Terminus of the Third Intracellular Loop of the α2A-Adrenergic Receptor (1995) (28)
- The pharmacogenetics of asthma: a candidate gene approach (2001) (26)
- Transcriptional response to persistent beta2-adrenergic receptor signaling reveals regulation of phospholamban, which alters airway contractility. (2006) (26)
- α2A/α2C-Adrenergic Receptor Third Loop Chimera Show That Agonist Interaction with Receptor Subtype Backbone Establishes G Protein-coupled Receptor Kinase Phosphorylation* (2000) (26)
- False positive non‐synonymous polymorphisms of G‐protein coupled receptor genes (2002) (25)
- Polymorphisms of β-adrenergic receptors in heart failure (2004) (25)
- Desensitization of the beta-adrenergic receptor: distinct molecular determinants of phosphorylation by specific kinases. (1991) (25)
- Yohimbine Dimers Exhibiting Selectivity for the Human α2c-Adrenoceptor Subtype (2002) (25)
- A Genome-Wide Association Study of Idiopathic Dilated Cardiomyopathy in African Americans (2018) (24)
- Role of the amino terminus of the third intracellular loop in agonist-promoted downregulation of the alpha2A-adrenergic receptor. (1997) (24)
- A functional polymorphism of the Galphaq (GNAQ) gene is associated with accelerated mortality in African-American heart failure. (2007) (23)
- Molecular and genetic basis of beta2-adrenergic receptor function. (1999) (23)
- Pharmacogenomics of β‐Adrenergic Receptors and Their Accessory Signaling Proteins in Heart Failure (2008) (23)
- β-Arrestin2 oligomers impair the clearance of pathological tau and increase tau aggregates (2020) (23)
- Activity of the uptake-1 norepinephrine transporter as measured by I-123 MIBG in heart failure patients with a loss-of-function polymorphism of the presynaptic α2C-adrenergic receptor (2003) (22)
- Perspectives of the Breast Cancer Survivorship Continuum: Diagnosis through 30 Months Post-Treatment (2015) (22)
- Genetic Variation Within the β1-Adrenergic Receptor Gene Results in Haplotype-Specific Expression Phenotypes (2008) (22)
- Reply to: Activation of BK channels may not be required for bitter tastant–induced bronchodilation (2012) (22)
- Pharmacogenomics of beta1-adrenergic receptor polymorphisms in heart failure. (2010) (22)
- Receptor-specific functional properties of beta 2-adrenergic receptor autoantibodies in asthma. (1995) (22)
- Striated muscle tropomyosin isoforms differentially regulate cardiac performance and myofilament calcium sensitivity (2010) (22)
- Multiple interactions between the alpha2C- and beta1-adrenergic receptors influence heart failure survival (2008) (21)
- Fusion of beta 2-adrenergic receptor to G alpha s in mammalian cells: identification of a specific signal transduction species not characteristic of constitutive activation or precoupling. (2000) (20)
- Beta-adrenoceptor-effector system of the human macrophage U937 cell line. (1989) (20)
- Substitution of an extracellular cysteine in the beta 2-adrenergic receptor enhances agonist-promoted phosphorylation and receptor desensitization. (1989) (20)
- Transgenic replacement of type V adenylyl cyclase identifies a critical mechanism of beta-adrenergic receptor dysfunction in the G alpha q overexpressing mouse. (1999) (20)
- Full-genome sequence and analysis of a novel human rhinovirus strain within a divergent HRV-A clade (2009) (20)
- A microphysiological model of the bronchial airways reveals the interplay of mechanical and biochemical signals in bronchospasm (2019) (20)
- Temporal analysis of mRNA and miRNA expression in transgenic mice overexpressing Arg- and Gly389 polymorphic variants of the β1-adrenergic receptor. (2011) (19)
- Pleiotropic beta-agonist-promoted receptor conformations and signals independent of intrinsic activity. (2007) (19)
- The two-timing thyroid (2004) (19)
- α2A-Adrenergic Receptors in the Genetics, Pathogenesis, and Treatment of Type 2 Diabetes (2009) (19)
- Role of βARK in Long-Term Agonist-Promoted Desensitisation of the β2-Adrenergic Receptor (1998) (19)
- Beta2-adrenergic receptor polymorphisms and sudden cardiac death: a signal to follow. (2006) (19)
- β2-Adrenergic Receptors Chaperone Trapped Bitter Taste Receptor 14 to the Cell Surface as a Heterodimer and Exert Unidirectional Desensitization of Taste Receptor Function* (2016) (19)
- Multiple potential regulatory elements in the 5' flanking region of the beta 3-adrenergic receptor. (1991) (18)
- Variable-length poly-C tract polymorphisms of the beta2-adrenergic receptor 3'-UTR alter expression and agonist regulation. (2008) (18)
- Coding block and 5 leader cistron polymorphisms of the beta2-adrenergic receptor. (1999) (17)
- Activated cofilin exacerbates tau pathology by impairing tau-mediated microtubule dynamics (2019) (17)
- Yohimbine dimers exhibiting selectivity for the human alpha 2C-adrenoceptor subtype. (2002) (17)
- Biased TAS2R Bronchodilators Inhibit Airway Smooth Muscle Growth by Downregulating Phosphorylated Extracellular Signal‐regulated Kinase 1/2 (2019) (16)
- Genetic variability of the β2 adrenergic receptor and asthma exacerbations (2006) (16)
- Heterogeneity in beta-adrenergic receptor kinase expression in the lung accounts for cell-specific desensitization of the beta2-adrenergic receptor. (1997) (16)
- Identification and characterization of a homogeneous population of beta 2-adrenergic receptors on human alveolar macrophages. (1989) (16)
- Functional Genomics of Lung Disease (2004) (15)
- Activated cofilin exacerbates tau pathology by impairing tau-mediated microtubule dynamics (2019) (15)
- Human tissue adrenergic receptors are not predictive of responses to epinephrine in vivo. (1989) (14)
- Bitter taste receptors in the wrong place: novel airway smooth muscle targets for treating asthma. (2014) (14)
- Functional alpha 2-adrenergic receptor-Gs coupling undergoes agonist-promoted desensitization in a subtype-selective manner. (1993) (14)
- Genetics of beta 2-adrenergic receptor variants in asthma. (1995) (13)
- Differential coupling of Arg- and Gly389 polymorphic forms of the beta1-adrenergic receptor leads to pathogenic cardiac gene regulatory programs. (2008) (13)
- Phosphorylation of Ser360 in the third intracellular loop of the alpha2A-adrenoceptor during protein kinase C-mediated desensitization. (2002) (13)
- An internal domain of beta-tropomyosin increases myofilament Ca(2+) sensitivity. (2009) (12)
- Medetomidine analogs as selective agonists for the human α2-adrenoceptors (2004) (12)
- Serine 232 of the alpha(2A)-adrenergic receptor is a protein kinase C-sensitive effector coupling switch. (2001) (12)
- Allele-specific binding of airway nuclear extracts to polymorphic beta2-adrenergic receptor 5' sequence. (2007) (12)
- Tropomyosin pseudo-phosphorylation results in dilated cardiomyopathy (2018) (12)
- Cardiac 7-transmembrane-spanning domain receptor portfolios: diversify, diversify, diversify. (2006) (11)
- A CREB‐mediated increase in miRNA let‐7f during prolonged β‐agonist exposure: a novel mechanism of β2‐adrenergic receptor down‐regulation in airway smooth muscle (2018) (11)
- Paradoxical attenuation of β2-AR function in airway smooth muscle by Gi-mediated counterregulation in transgenic mice overexpressing type 5 adenylyl cyclase. (2011) (11)
- Biased TAS2R Bronchodilators Inhibit Airway Smooth Muscle Growth by Downregulating pERK1/2 (2019) (10)
- Electrical pacing induces adenylyl cyclase in skeletal muscle independent of the beta-adrenergic receptor. (1992) (10)
- Heterogeneity of transcription factor expression and regulation in human airway epithelial and smooth muscle cells. (2007) (10)
- Update on current concepts of the basis of β2-adrenergic receptor signaling (2002) (9)
- Subcellular distribution of beta 2-adrenergic receptors delineated with quantitative ultrastructural autoradiography of radioligand binding sites. (1992) (9)
- Pepducins as a potential treatment strategy for asthma and COPD. (2018) (9)
- Structural determinants of alpha 2-adrenergic receptor regulation. (1998) (8)
- Bitransgenesis with β2‐Adrenergic Receptors or Adenylyl Cyclase Fails to Improve β1‐Adrenergic Receptor Cardiomyopathy (2008) (8)
- Hearts : Critical Role for Expression Level-Adrenergic Receptor Overexpression in Mouse 2 β Early and Delayed Consequences of Print (2000) (8)
- Polymorphisms in human heat shock factor-1 and analysis of potential biological consequences (2014) (7)
- Polymorphisms of the b 2 -Adrenergic Receptor Determine Exercise Capacity in Patients With Heart Failure (2000) (7)
- Differential long‐term regulation of TAS2R14 by structurally distinct agonists (2019) (7)
- Identification and characterization of an atypical Gαs-biased β2AR agonist that fails to evoke airway smooth muscle cell tachyphylaxis (2021) (6)
- Polymorphisms of beta-adrenergic receptors in heart failure. (2004) (6)
- Pharmacogenetics of beta1-adrenergic receptors in heart failure and hypertension. (2006) (6)
- The odorant receptor OR2W3 on airway smooth muscle evokes bronchodilation via a cooperative chemosensory tradeoff between TMEM16A and CFTR (2020) (6)
- Targeted transgenesis identifies Gαs as the bottleneck in β2-adrenergic receptor cell signaling and physiological function in airway smooth muscle. (2014) (6)
- Genetic, Molecular, and Clinical Characterization of Adrenergic Receptor Polymorphisms (2006) (5)
- Medetomidine analogs as selective agonists for the human alpha2-adrenoceptors. (2004) (5)
- Genome Sequences of Rhinovirus C Isolates from Wisconsin Pediatric Respiratory Studies (2014) (5)
- Long-distance affair with adrenal GRK2 hangs up heart failure (2007) (5)
- Genome Sequences of Rhinovirus A Isolates from Wisconsin Pediatric Respiratory Studies (2014) (5)
- β-arrestin1 promotes tauopathy by transducing GPCR signaling, disrupting microtubules and autophagy (2021) (5)
- Racial differences in the frequencies of cardiac β1-adrenergic receptor polymorphisms: Analysis of c145A>G and c1165G>C Communicated by: R.G.H. Cotton Online Citation: Human Mutation, Mutation and Polymorphism Report #65 (1999) Online http://journals.wiley.com/1059-7794/pdf/mutation/mpr65.pdf (1999) (4)
- Identification and Characterization of Novel Bronchodilator Agonists Acting at Human Airway Smooth Muscle Cell TAS2R5. (2020) (4)
- α1B/D-adrenoceptors regulate chemokine receptor–mediated leukocyte migration via formation of heteromeric receptor complexes (2022) (4)
- Biased β-Agonists Favoring Gs over β-Arrestin for Individualized Treatment of Obstructive Lung Disease (2022) (4)
- Cardiomyopathy Induced −-Adrenergic β Common Genomic Response in Different Mouse Models of Print (2003) (4)
- Dose Response of &bgr;-Blockers in Adrenergic Receptor Polymorphism Genotypes (2018) (4)
- Cerebrospinal fluid xanthochromia with rifampin (1982) (4)
- G-protein coupled receptors, nitric oxide, and the IgE receptor in asthma. (1995) (4)
- Plastic adenylyl cyclase. (1999) (4)
- Role of beta ARK in long-term agonist-promoted desensitisation of the beta 2-adrenergic receptor. (1998) (3)
- Hypoglycemia in the Critically Ill Patient (1986) (3)
- Genome Sequences of Rhinovirus B Isolates from Wisconsin Pediatric Respiratory Studies (2014) (3)
- Lymphocyte GRK levels as biomarkers in heart failure. (2005) (3)
- G PROTEIN RECEPTOR KINASE 4 ( GRK 4 ) POLYMORPHISMS : BETA-BLOCKER PHARMACOGENETICS AND TREATMENT RELATED OUTCOMES IN HYPERTENSION (3)
- Structures and Agonist Binding Sites of Bitter Taste Receptor TAS2R5 Complexed with Gi Protein and Validated against Experiment. (2021) (3)
- Development of a Rhinovirus Inoculum Using a Reverse Genetics Approach (2018) (3)
- Rhinovirus C15 Induces Airway Hyperresponsiveness Via Calcium Mobilization in Airway Smooth Muscle. (2020) (3)
- Antithetic regulation by b-adrenergic receptors of G q receptor signaling via phospholipase C underlies the airway b-agonist paradox (2018) (3)
- Role of the beta-adrenergic receptor kinase in desensitization of the alpha 2-adrenergic receptor. (1991) (2)
- G-PROTEIN-COUPLED RECEPTORS (2006) (2)
- Erratum: The effect of polymorphisms of the beta(2)-adrenergic receptor on the response to regular use of albuterol in asthma (International Archives of Allergy and Immunology (2000) 162 (75-80)) (2012) (2)
- Ischemic Cardiomyopathy Response to Bucindolol May Be Differentially Influenced by b1 389 Arg/Gly and a2c Genotypes (2008) (2)
- Genetic Vulnerability of GPCRs: A Call to Action. (2018) (2)
- Different Patterns of LVEF/Remodeling and Clinical Endpoint Effects for Bucindolol in b1-AR 389 Arg/Gly Genotypes (2008) (2)
- An internal domain of -tropomyosin increases myofilament Ca sensitivity (2009) (2)
- Adrenergic receptor polymorphisms in heart failure: molecular and physiological phenotypes (2005) (2)
- Adrenergic receptors are a fallible index of adrenergic denervation hypersensitivity. (1991) (2)
- A microphysiological model of the bronchial airways reveals the interplay of mechanical and biochemical signals in bronchospasm (2019) (1)
- Peripheral Blood Gene Expression Changes Predict Mortality and Treatment Response in Acute Covid-19 and Associate with Lung Fibrosis (2022) (1)
- Propylhexedrine Intoxication: Clinical Presentation and Pharmacology. (1982) (1)
- Regulatory Haplotypes In ARG1 Are Associated With Bronchodilator Response (2010) (1)
- Abstract 2001: Genetic {beta}-Blockade: A G-Protein Coupled Receptor Kinase-5 Polymorphism That Inhibits Beta-Adrenergic Receptor Signaling is Protective in Heart Failure (2006) (1)
- Determination of Hospitalization Type by Investigator Case Report Form or Adjudication Committee in a Large Heart Failure Clinical Trial (BEST) (2008) (1)
- Structural basis for receptor subtype-specific regulation revealed by a chimeric 83 / j 82-adrenergic receptor ( desensitization / phosphorylatlon / down-regulation / adenylyl cyclase ) (1)
- Histamine N‐methyltransferase (HNMT) pharmacogenetics: Association of the C314T genetic polymorphism with allergic asthma (1999) (1)
- A Par3/LIM Kinase/Cofilin Pathway Mediates Human Airway Smooth Muscle Relaxation by TAS2R14. (2023) (1)
- Rapid Communication Subcellular Distribution of 32-Adrenergic Receptors Delineated With Quantitative Ultrastructural Autoradiography of Radioligand Binding Sites (2005) (1)
- (cid:1) 2 -Adrenergic Receptor Polymorphisms and Sudden Cardiac Death A Signal to Follow (2006) (1)
- Detailed sequence and haplotype analysis of the beta-2 adrenergic receptor gene in Caucasians and African Americans (2005) (1)
- Failure of pressure overload hypertrophy in Gαq overexpressing mice (1998) (1)
- Polymorphisms of heat shock factor‐1: Genetic diversity in an evolutionarily conserved, multifunctional regulator gene (2011) (1)
- Abstract 754: Expression Analysis and Functional Significance of a Novel Cardiac Specific Human Tropomyosin in Normal and Cardiomyopathy Patients (2007) (1)
- Upregulation Of Bitter Taste Receptor Cell Surface Expression By Chronic Agonist: A Novel Trafficking Outcome That May Minimize Tachyphylaxis (2012) (1)
- A Novel Photo-electrochemical Oxidation Air-Purification Technology Reduces Asthma Symptoms (2018) (0)
- Role of cofilin in tau/microtubule dynamics and tauopathy (2019) (0)
- Differential Effects of β-1 Polymorphisms on Mortality, Hospitalizations, and Myocardial Infarctions with Bucindolol Therapy (2006) (0)
- The Relaxation Effect of Pitavastatin on Human Airway Smooth Muscle Cells: A Role for Acute F-actin Disruption (2023) (0)
- R treatment with bucindolol (2005) (0)
- Death‐associated protein kinase mediates myofibril degeneration and myocyte apoptosis induced by beta‐adrenergic receptors (404.3) (2014) (0)
- Potato Crisp moisture determination using NIR data and a Back Propagation Neural Network (2013) (0)
- transgenic mice overexpressing type 5 adenylyl cyclase -mediated counterregulation in i smooth muscle by G -AR function in airway (2016) (0)
- Procedures for risk assessment, survival prediction and treatment of heart failure and other suffering on the basis of polymorphisms of adrenergic receptors (2004) (0)
- Evolution and structure of human rhinoviruses as determined from full genome sequences (2010) (0)
- Non-genetic Insights Into the Functional Efficacy of β2-adrenoreceptors in Human Airway Smooth Muscle Cells Through the Lens of Bitter Taste Receptors (2023) (0)
- Pharmacogenetics of Respiratory Disease (2016) (0)
- Report of the Working Group on functional genetics/molecular approaches to asthma genetics (1998) (0)
- P431 Novel photo-electrochemical oxidation air-purifiication technology reduces nasal and ocular allergy symptoms (2017) (0)
- Bitter Taste Receptor Signaling On Airway Smooth Muscle: A Highly Efficacious Pathway For Treating Obstructive Airway Disease (2011) (0)
- Pharmacogenomics of b 1 -Adrenergic Receptor Polymorphisms in Hear t Failure (2010) (0)
- β-ADRENERGIC RECEPTOR DESENSITIZATION DURING CARDIOPULMONARY BYPASS (1991) (0)
- Ongoing Promises and Public Expectations of the HGP (0)
- β‐arrestin2 oligomers impair the clearance of pathological tau and increase tau aggregates (2020) (0)
- Polymorphisms Of Heat Shock Factor-1: Genetic Diversity With The Prospect Of Functional Variability Relevant To Heat Shock And Inflammation (2011) (0)
- Regulation of Intracellular Calcium by Bitter Taste Receptors on Airway Smooth Muscle (2014) (0)
- TAS 2 R Activation Promotes Airway Smooth Muscle Relaxation Despite β 2-Adrenergic 1 Receptor Tachyphylaxis 2 3 (2012) (0)
- Past Successes of Genetic Findings Familial Hypercholesterolemia and Low-Density Lipoprotein Cholesterol Lowering (2015) (0)
- β-Adrenergic Receptors (2004) (0)
- Chapter 45 – Adrenergic Receptor Polymorphisms in Heart Failure (2012) (0)
- Tight control of adrenal medulla catecholamine release by alpha 2C-adrenergic receptors influences susceptibility to heart failure. (2007) (0)
- Abstract 398: Pharmacogenetic Therapeutic Enhancement of a Prespecified Composite Morbidity-Mortality Measurement in BEST (2006) (0)
- Bitter Taste Receptors and Bronchodilation (2016) (0)
- The Ile164 β2-adrenergic receptor polymorphism is associated with decreased exercise capacity in patients with heart failure (1999) (0)
- Whole Transcriptome Analysis Of Mutated ²2-Adrenergic Receptors Reveals "Ancillary Pathways" Attributable To Receptor Phosphorylation By GRKs And PKA (2012) (0)
- Abstract 2177: Differential Effects of {beta}-1 Polymorphisms on Mortality, Hospitalizations, and Myocardial Infarctions with Bucindolol Therapy. (2006) (0)
- MECHANISMS OF DYSFUNCTIONAL BETA 2-ADRENERGIC SIGNALING IN FATAL ASTHMA (1998) (0)
- Clinical and molecular implications of RGS2 promoter genetic variation in severe asthma (2022) (0)
- Receptor Affect Agonist-Promoted Trafficking (2002) (0)
- Selective Signal Capture from Multidimensional GPCR Outputs with Biased Agonists: Progress Towards Novel Drug Development (2022) (0)
- The short third intracellular loop and cytoplasmic tail of bitter taste receptors provide functionally relevant GRK phosphorylation sites in TAS2R14 (2021) (0)
- Association d'haplotypes du recepteur adrenergique beta2 reagissant aux medicaments (2000) (0)
- Hereditary dysautonomias: current knowledge and collaborations for the future (2003) (0)
- Epigenetics Of The ²2-Adrenergic Receptor Gene (2010) (0)
- Abstract 2912: Effect of {beta}1 389 Arg/Gly {alpha}2c 322 325 Wt/Del Genotypes on Adjudicated Hospitalizations in the BEST Trial (2007) (0)
- An Internal Domain of Beta Tropomyosin Increases Myofilament Calcium Sensitivity (2009) (0)
- ' s personal copy Pharmacogenomics of b 1-Adrenergic Receptor Polymorphisms in Heart Failure (2009) (0)
- Polymorphisms of theb2-Adrenergic Receptor Determine Exercise Capacity in Patients With Heart Failure (2000) (0)
- Enhanced Ca2+ transient and cell contractility is associated with decreased Cx43 in β1-ARG389 mice (2007) (0)
- WITHDRAWN: Enhanced Ca2+ transient & cell contractility is associated with decreased Cx43 in β1-ARG389 mice (2007) (0)
- Title Inhibition of PI 3 K promotes dilation of human small airways in a rho kinase-dependent manner (2016) (0)
- Bitter Taste Receptors And β2-Adrenergic Receptors Mediate Relaxation Of Airway Smooth Muscle In An Additive Manner (2012) (0)
- Preface to Special Issue on ‘Cytochrome P450 Variation in Pharmacogenomics’ (2018) (0)
- Deep Resequencing of the Beta-2 Adrenergic Receptor Gene (ADRB2) in COPD and Asthma Cohorts Identifies Functional Rare Variants (2020) (0)
- Clinical and molecular implications of RGS2 promoter genetic variation in severe asthma. (2022) (0)
- Chloroquine, A TAS2R Agonist, Promotes Airway Smooth Muscle Relaxation Despite B2Adrenergic Receptor Tachyphylaxis (2012) (0)
- Polymorphisms in human heat shock factor-1 and analysis of potential biological consequences (2014) (0)
- G-Protein Receptor Kinase-5 Polymorphism Influences Therapeutic Efficacy of β-Blockers in Heart Failure (2006) (0)
- Predicted structure and cell signaling of TAS2R14 reveal receptor hyper-flexibility for detecting diverse bitter tastes. (2023) (0)
- Sequence Analysis of a Cloned Human Rhinovirus Designed For Use in Human Inoculation Studies (2012) (0)
- Agonist-Promoted Desensitization Of Bitter Taste Receptors Expressed On Airway Smooth Muscle (2011) (0)
- Discovery and Characterization of the First Biased Beta-Agonist That Favors Gs-Coupling vs Beta-Arrestin Mediated Desensitization: A New Class of Structurally Distinct Beta-Agonists for Treating Obstructive Lung Diseases (2022) (0)
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