Stephen Elledge

Q: What Schools Are Affiliated With Stephen Elledge

Stephen Elledge is affiliated with the following schools: Washington University in St. Louis, Kyushu University, Cold Spring Harbor Laboratory School of Biological Sciences, University of California, San Diego, Tel Aviv University, Stanford University, Massachusetts Institute of Technology, Baylor College of Medicine, University of Illinois Urbana-Champaign, University of Washington, Massachusetts General Hospital, Harvard University

Stephen Elledge's AcademicInfluence.com Rankings

Stephen Elledge

Biology

#1252

World Rank

#2126

Historical Rank

#641

USA Rank

Genetics

#113

World Rank

#150

Historical Rank

#71

USA Rank

biology Degrees

Download Badge

Biology

Stephen Elledge's Degrees

PhD Biochemistry University of Washington
Bachelors Chemistry University of Washington

Why Is Stephen Elledge Influential?

(Suggest an Edit or Addition)

According to Wikipedia, Stephen Joseph Elledge is an American geneticist. He is the current Gregor Mendel Professor of Genetics and of Medicine at the Department of Genetics of Harvard Medical School and in the Division of Genetics of the Brigham and Women's Hospital. His research is focused on the genetic and molecular mechanisms of eukaryotic response to DNA damage and is known as the discoverer of the DNA damage response .

(See a Problem?)

Stephen Elledge's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases (1993) (5827)
The DNA damage response: making it safe to play with knives. (2010) (3660)
The DNA damage response: putting checkpoints in perspective (2000) (3311)
ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage (2007) (3001)
Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes (2003) (2643)
Mice Lacking p21 CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control (1995) (2185)
Cell Cycle Checkpoints: Preventing an Identity Crisis (1996) (2183)
Dicer is essential for mouse development (2003) (1998)
Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. (2000) (1712)
The DNA damage response: ten years after. (2007) (1663)
A quantitative atlas of mitotic phosphorylation (2008) (1572)
p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest (1994) (1551)
The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit. (1993) (1485)
Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. (1998) (1428)
Structure of the Cul1–Rbx1–Skp1–F boxSkp2 SCF ubiquitin ligase complex (2002) (1420)
SKP1 Connects Cell Cycle Regulators to the Ubiquitin Proteolysis Machinery through a Novel Motif, the F-Box (1996) (1419)
Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction (2009) (1386)
Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. (1997) (1386)
DNA damage-induced activation of p53 by the checkpoint kinase Chk2. (2000) (1329)
F-Box Proteins Are Receptors that Recruit Phosphorylated Substrates to the SCF Ubiquitin-Ligase Complex (1997) (1316)
BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. (2000) (1285)
Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen (2007) (1191)
The IFITM Proteins Mediate Cellular Resistance to Influenza A H1N1 Virus, West Nile Virus, and Dengue Virus (2009) (1180)
Cyclin D1 provides a link between development and oncogenesis in the retina and breast (1995) (1092)
Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks. (1999) (1071)
Inhibition of cyclin-dependent kinases by p21. (1995) (1063)
ATR and ATRIP: Partners in Checkpoint Signaling (2001) (1007)
A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene (2009) (974)
p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene. (1995) (971)
Harnessing homologous recombination in vitro to generate recombinant DNA via SLIC (2007) (934)
MDC1 is a mediator of the mammalian DNA damage checkpoint (2003) (918)
Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro. (2000) (871)
The SCFβ-TRCP–ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IκBα and β-catenin and stimulates IκBα ubiquitination in vitro (1999) (861)
Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle (1992) (847)
Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy (2017) (827)
Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1 (1993) (823)
Phosphorylation-Dependent Ubiquitination of Cyclin E by the SCFFbw7 Ubiquitin Ligase (2001) (803)
Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase. (1999) (786)
Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith–Wiedemann syndrome (1997) (784)
Meta- and Orthogonal Integration of Influenza "OMICs" Data Defines a Role for UBR4 in Virus Budding. (2015) (773)
Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis (1996) (733)
A resource for large-scale RNA-interference-based screens in mammals (2004) (725)
Abraxas and RAP80 Form a BRCA1 Protein Complex Required for the DNA Damage Response (2007) (706)
Identification of the FANCI Protein, a Monoubiquitinated FANCD2 Paralog Required for DNA Repair (2007) (688)
Second-generation shRNA libraries covering the mouse and human genomes (2005) (666)
Systematic analysis and nomenclature of mammalian F-box proteins. (2004) (651)
Regulation of RAD53 by the ATM-Like Kinases MEC1 and TEL1 in Yeast Cell Cycle Checkpoint Pathways (1996) (650)
Cumulative Haploinsufficiency and Triplosensitivity Drive Aneuploidy Patterns and Shape the Cancer Genome (2013) (614)
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4 (2015) (612)
53BP1, a Mediator of the DNA Damage Checkpoint (2002) (606)
Insights into SCF ubiquitin ligases from the structure of the Skp1–Skp2 complex (2000) (598)
Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms. (1999) (588)
Genomic expression responses to DNA-damaging agents and the regulatory role of the yeast ATR homolog Mec1p. (2001) (581)
Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction (2009) (577)
A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells. (2005) (560)
The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo (2011) (554)
Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. (2000) (550)
Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin. (2002) (546)
The DNA Replication and Damage Checkpoint Pathways Induce Transcription by Inhibition of the Crt1 Repressor (1998) (537)
Mrc1 transduces signals of DNA replication stress to activate Rad53 (2001) (534)
Distinct Patterns of IFITM-Mediated Restriction of Filoviruses, SARS Coronavirus, and Influenza A Virus (2011) (530)
A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage (2010) (519)
The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast. (1994) (513)
RNA interference screen for human genes associated with West Nile virus infection (2008) (505)
The Fanconi Anemia Pathway Promotes Replication-Dependent DNA Interstrand Cross-Link Repair (2009) (500)
BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3 (2003) (500)
A Genetic Screen for Candidate Tumor Suppressors Identifies REST (2005) (494)
Homologous recombination-deficient tumors are hyper-dependent on POLQ-mediated repair (2015) (487)
Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis (2022) (482)
Transcriptional regulation and function during the human cell cycle (2001) (473)
Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions (1997) (467)
Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway. (1998) (466)
Mammalian BTBD12/SLX4 Assembles A Holliday Junction Resolvase and Is Required for DNA Repair (2009) (464)
Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage (2007) (463)
How the Cyclin Became a Cyclin Regulated Proteolysis in the Cell Cycle (1999) (463)
Replication protein A-mediated recruitment and activation of Rad17 complexes (2003) (454)
Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity (2020) (452)
Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase delta holoenzyme. (1994) (445)
Multiple Tumor Suppressor Pathways Negatively Regulate Telomerase (2003) (440)
Cdk inhibitors in development and cancer. (1996) (427)
The ubiquitin-specific protease USP28 is required for MYC stability (2007) (408)
p21(CIP1) and p57(KIP2) control muscle differentiation at the myogenin step. (1999) (408)
Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1. (1999) (406)
Global Protein Stability Profiling in Mammalian Cells (2008) (405)
The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro. (1999) (397)
Cancer Proliferation Gene Discovery Through Functional Genomics (2008) (396)
A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal. (2009) (395)
A SUMOylation-Dependent Transcriptional Subprogram Is Required for Myc-Driven Tumorigenesis (2012) (391)
DNA polymerase ϵ links the DNA replication machinery to the S phase checkpoint (1995) (389)
Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53. (2003) (386)
Chk2 Is a Tumor Suppressor That Regulates Apoptosis in both an Ataxia Telangiectasia Mutated (ATM)-Dependent and an ATM-Independent Manner (2002) (386)
SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex. (1999) (385)
Mutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determination (2000) (379)
A family of mammalian F-box proteins (1999) (378)
Cdk inhibitors: on the threshold of checkpoints and development. (1994) (373)
A genome-wide genetic screen for host factors required for hepatitis C virus propagation (2009) (371)
Checking on the fork: the DNA-replication stress-response pathway. (2002) (370)
SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase. (2003) (370)
Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities (2007) (365)
Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle. (1992) (359)
A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA damage response (2012) (355)
Supplemental Data The IFITM Proteins Mediate Cellular Resistance to Influenza A H 1 N 1 Virus , West Nile Virus , and Dengue Virus (2009) (347)
Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases. (2004) (345)
A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair. (2010) (344)
Non-Oncogene Addiction and the Stress Phenotype of Cancer Cells (2007) (340)
DUN1 encodes a protein kinase that controls the DNA damage response in yeast (1993) (339)
IFITM3 Inhibits Influenza A Virus Infection by Preventing Cytosolic Entry (2011) (333)
Lambda YES: a multifunctional cDNA expression vector for the isolation of genes by complementation of yeast and Escherichia coli mutations. (1991) (332)
Cooperation between the Cdk inhibitors p27(KIP1) and p57(KIP2) in the control of tissue growth and development. (1998) (331)
Site-directed insertion and deletion mutagenesis with cloned fragments in Escherichia coli (1985) (321)
Origins of lymphatic and distant metastases in human colorectal cancer (2017) (319)
A Role for the Deubiquitinating Enzyme USP28 in Control of the DNA-Damage Response (2006) (319)
Profiling Essential Genes in Human Mammary Cells by Multiplex RNAi Screening (2008) (316)
Imprinting of the gene encoding a human cyclin-dependent kinase inhibitor, p57KIP2, on chromosome 11p15. (1996) (312)
SCFβ-TRCP controls oncogenic transformation and neural differentiation through REST degradation (2008) (307)
Specific association between the human DNA repair proteins XPA and ERCC1. (1994) (305)
Ribonucleotide reductase: regulation, regulation, regulation. (1992) (300)
Comprehensive serological profiling of human populations using a synthetic human virome (2015) (295)
Two genes differentially regulated in the cell cycle and by DNA-damaging agents encode alternative regulatory subunits of ribonucleotide reductase. (1990) (295)
PICK1: a perinuclear binding protein and substrate for protein kinase C isolated by the yeast two-hybrid system (1995) (292)
Direct DNA binding by Brca1 (2001) (280)
Activation of Multiple Proto-oncogenic Tyrosine Kinases in Breast Cancer via Loss of the PTPN12 Phosphatase (2011) (277)
The univector plasmid-fusion system, a method for rapid construction of recombinant DNA without restriction enzymes (1998) (276)
Regulation of the Bub2/Bfa1 GAP Complex by Cdc5 and Cell Cycle Checkpoints (2001) (271)
Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein. (2004) (268)
Proteins required for ultraviolet light and chemical mutagenesis. Identification of the products of the umuC locus of Escherichia coli. (1983) (266)
Lessons from Nature: microRNA-based shRNA libraries (2006) (266)
Quantitative Proteomic Atlas of Ubiquitination and Acetylation in the DNA Damage Response. (2015) (263)
The SUMO-1 isopeptidase Smt4 is linked to centromeric cohesion through SUMO-1 modification of DNA topoisomerase II. (2002) (262)
Global Identification of Modular Cullin-RING Ligase Substrates (2011) (258)
WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase (2009) (254)
Chk1 is haploinsufficient for multiple functions critical to tumor suppression. (2004) (250)
FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway (2008) (242)
Hepatitis B virus X protein interacts with a probable cellular DNA repair protein (1995) (242)
Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop (2012) (238)
DNA damage and cell cycle regulation of ribonucleotide reductase (1993) (238)
SLIC: a method for sequence- and ligation-independent cloning. (2012) (238)
Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress. (2012) (237)
Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens (2019) (229)
Cytosolic 5′‐nucleotidase 1A autoimmunity in sporadic inclusion body myositis (2013) (228)
Wnt signaling regulates mitochondrial physiology and insulin sensitivity. (2010) (226)
FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex. (2008) (225)
The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome. (2010) (218)
Reactivation of latent HIV-1 by inhibition of BRD4. (2012) (213)
Functional identification of optimized RNAi triggers using a massively parallel sensor assay. (2011) (212)
umuDC and mucAB operons whose products are required for UV light- and chemical-induced mutagenesis: UmuD, MucA, and LexA proteins share homology. (1985) (209)
CDK2 encodes a 33-kDa cyclin A-associated protein kinase and is expressed before CDC2 in the cell cycle. (1992) (205)
Autoantigen discovery with a synthetic human peptidome. (2011) (204)
A DNA Damage Response Screen Identifies RHINO, a 9-1-1 and TopBP1 Interacting Protein Required for ATR Signaling (2011) (203)
Identification and isolation of the gene encoding the small subunit of ribonucleotide reductase from Saccharomyces cerevisiae: DNA damage-inducible gene required for mitotic viability (1987) (202)
A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability. (2010) (199)
Identification of SCF Ubiquitin Ligase Substrates by Global Protein Stability Profiling (2008) (193)
Identification of RNR4, encoding a second essential small subunit of ribonucleotide reductase in Saccharomyces cerevisiae (1997) (192)
A family of versatile centromeric vectors designed for use in the sectoring-shuffle mutagenesis assay in Saccharomyces cerevisiae. (1988) (191)
The mitotic spindle is required for loading of the DASH complex onto the kinetochore. (2002) (188)
Gene identification using the yeast two-hybrid system. (1997) (187)
RAD9 and DNA polymerase epsilon form parallel sensory branches for transducing the DNA damage checkpoint signal in Saccharomyces cerevisiae. (1996) (186)
The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart. (2009) (185)
Recurrent Hemizygous Deletions in Cancers May Optimize Proliferative Potential (2012) (181)
The amino-terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that co-localizes to centers for RNA processing (1994) (180)
NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control. (2009) (179)
BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly. (2005) (178)
RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling (2007) (171)
Oppositely imprinted genes p57(Kip2) and igf2 interact in a mouse model for Beckwith-Wiedemann syndrome. (1999) (170)
Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATR. (2013) (168)
The role of Cdk7 in CAK function, a retro-retrospective. (1998) (165)
WSTF regulates the function of H2A.X via a novel tyrosine kinase activity (2008) (163)
Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence (2010) (163)
Asf1 links Rad53 to control of chromatin assembly. (2001) (162)
Role for the BRCA1 C-terminal Repeats (BRCT) Protein 53BP1 in Maintaining Genomic Stability* (2003) (154)
Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function (2006) (153)
The CD225 Domain of IFITM3 Is Required for both IFITM Protein Association and Inhibition of Influenza A Virus and Dengue Virus Replication (2013) (153)
Structure of the FANCI-FANCD2 Complex: Insights into the Fanconi Anemia DNA Repair Pathway (2011) (151)
Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation. (2004) (150)
Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action (2010) (149)
Low frequency of p57KIP2 mutation in Beckwith-Wiedemann syndrome. (1997) (144)
DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae. (1999) (143)
The Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Targeting C-Terminal Degrons (2018) (141)
Rad17 phosphorylation is required for claspin recruitment and Chk1 activation in response to replication stress. (2006) (141)
CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation. (2008) (140)
DNA polymerase epsilon links the DNA replication machinery to the S phase checkpoint. (1995) (139)
How autophagy both activates and inhibits cellular senescence (2016) (139)
Protein phosphatase 1 interacts with p53BP2, a protein which binds to the tumour suppressor p53 (1995) (138)
Recognition of Phosphodegron Motifs in Human Cyclin E by the SCFFbw7 Ubiquitin Ligase* (2004) (138)
Pds1 phosphorylation in response to DNA damage is essential for its DNA damage checkpoint function. (2001) (137)
Cancer: p53 sends nucleotides to repair DNA (2000) (136)
DNA damage induction of ribonucleotide reductase (1989) (134)
Design of 240,000 orthogonal 25mer DNA barcode probes (2009) (131)
Dif1 is a DNA-damage-regulated facilitator of nuclear import for ribonucleotide reductase. (2008) (130)
New yeast genes important for chromosome integrity and segregation identified by dosage effects on genome stability. (1999) (127)
The tumor suppressor CYLD regulates entry into mitosis (2007) (126)
MAGIC, an in vivo genetic method for the rapid construction of recombinant DNA molecules (2005) (125)
Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns (2018) (125)
G1 cyclin-dependent kinases are sufficient to initiate DNA synthesis in quiescent human fibroblasts (1998) (124)
A question of balance: the role of cyclin-kinase inhibitors in development and tumorigenesis. (1996) (123)
Isolation of crt mutants constitutive for transcription of the DNA damage inducible gene RNR3 in Saccharomyces cerevisiae. (1992) (122)
Life-threatening influenza pneumonitis in a child with inherited IRF9 deficiency (2018) (121)
Multiple genetic loci within 11p15 defined by Beckwith-Wiedemann syndrome rearrangement breakpoints and subchromosomal transferable fragments. (1995) (120)
Global Identification of Modular Cullin-RING Ligase Substrates (2012) (120)
A Systematic Analysis of Factors Localized to Damaged Chromatin Reveals PARP-Dependent Recruitment of Transcription Factors. (2015) (118)
Genome-wide shRNA screen revealed integrated mitogenic signaling between dopamine receptor D2 (DRD2) and epidermal growth factor receptor (EGFR) in glioblastoma (2014) (116)
Synthetic design of strong promoters (2010) (115)
ATM–Chk2–p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency (2006) (114)
Selective maternal-allele loss in human lung cancers of the maternally expressed p57KIP2 gene at 11p15.5. (1996) (113)
Finding prospective partners in the library: the two-hybrid system and phage display find a match. (1995) (113)
Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets. (2019) (110)
Systematic Identification of Synergistic Drug Pairs Targeting HIV (2012) (109)
Chromatin proteins captured by ChIP–mass spectrometry are linked to dosage compensation in Drosophila (2013) (108)
Towards genetic genome projects: genomic library screening and gene-targeting vector construction in a single step (2002) (108)
T-Scan: A Genome-wide Method for the Systematic Discovery of T Cell Epitopes (2019) (107)
Tissue-specificity in cancer: The rule, not the exception (2019) (106)
Position and density effects on repression by stationary and mobile DNA-binding proteins. (1989) (106)
The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression (2005) (105)
Hus1 Acts Upstream of Chk1 in a Mammalian DNA Damage Response Pathway (2002) (105)
The BRCA1 suppressor hypothesis: an explanation for the tissue-specific tumor development in BRCA1 patients. (2002) (104)
The Bfa1/Bub2 GAP complex comprises a universal checkpoint required to prevent mitotic exit (2000) (102)
Amphotericin B Increases Influenza A Virus Infection by Preventing IFITM3-Mediated Restriction (2013) (102)
A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability. (2010) (102)
A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling (2007) (100)
Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyclosome substrate (2011) (100)
C-Terminal End-Directed Protein Elimination by CRL2 Ubiquitin Ligases. (2018) (98)
Recruitment of fanconi anemia and breast cancer proteins to DNA damage sites is differentially governed by replication. (2009) (94)
Dominant genetics using a yeast genomic library under the control of a strong inducible promoter. (1992) (94)
Wolf–Hirschhorn syndrome candidate 1 is involved in the cellular response to DNA damage (2011) (94)
RFWD3-Dependent Ubiquitination of RPA Regulates Repair at Stalled Replication Forks. (2015) (93)
Exit from Exit Resetting the Cell Cycle through Amn1 Inhibition of G Protein Signaling (2003) (90)
A role for PVRL4-driven cell–cell interactions in tumorigenesis (2013) (89)
How ATR turns on: TopBP1 goes on ATRIP with ATR. (2008) (88)
Genetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway. (2002) (88)
Treacher Collins syndrome TCOF1 protein cooperates with NBS1 in the DNA damage response (2014) (88)
The role of protein stability in the cell cycle and cancer. (1998) (87)
A glycine-specific N-degron pathway mediates the quality control of protein N-myristoylation (2019) (87)
Ran-binding Protein-1 Is an Essential Component of the Ran/RCC1 Molecular Switch System in Budding Yeast (*) (1995) (86)
Lambda gt 11: gene isolation with antibody probes and other applications. (1987) (86)
Isolation of a cDNA encoding a metal response element binding protein using a novel expression cloning procedure: the one hybrid system. (1994) (85)
Human Cyclin K, a Novel RNA Polymerase II-Associated Cyclin Possessing Both Carboxy-Terminal Domain Kinase and Cdk-Activating Kinase Activity (1998) (84)
Control of ribonucleotide reductase localization through an anchoring mechanism involving Wtm1. (2006) (83)
The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning (2020) (83)
Stopped for repairs. (1995) (80)
Cyclin F Disruption Compromises Placental Development and Affects Normal Cell Cycle Execution (2004) (80)
Nudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling (2018) (77)
The muc genes of pKM101 are induced by DNA damage (1983) (75)
Identification of the DNA damage-responsive element of RNR2 and evidence that four distinct cellular factors bind it (1989) (75)
Systematic autoantigen analysis identifies a distinct subtype of scleroderma with coincident cancer (2016) (75)
SARS-CoV-2 hijacks folate and one-carbon metabolism for viral replication (2021) (74)
PhIP-Seq characterization of autoantibodies from patients with multiple sclerosis, type 1 diabetes and rheumatoid arthritis. (2013) (73)
Cyclin D- and E-Dependent Kinases and the p57KIP2 Inhibitor: Cooperative Interactions In Vivo (1999) (73)
53BP1 Oligomerization is Independent of its Methylation by PRMT1 (2005) (72)
Human CPR (cell cycle progression restoration) genes impart a Far- phenotype on yeast cells. (1997) (71)
Genomic instability and endoreduplication triggered by RAD17 deletion. (2003) (69)
Cross-talk between Chk1 and Chk2 in double-mutant thymocytes (2007) (68)
Isolation of temperature-sensitive diphtheria toxins in yeast and their effects on Drosophila cells. (1992) (68)
Mitotic Arrest: Mad2 Prevents Sleepy from Waking Up the APC (1998) (68)
Isolation and characterization of Tn5 insertion mutations in the lexA gene of Escherichia coli (1983) (63)
A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells. (2017) (63)
Renal-retinal ciliopathy gene Sdccag8 regulates DNA damage response signaling. (2014) (63)
Interactions among vertebrate helix-loop-helix proteins in yeast using the two-hybrid system. (1993) (59)
A genetic interaction analysis identifies cancer drivers that modify EGFR dependency. (2017) (59)
Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1 (2014) (58)
Nudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling (2018) (56)
Brief Report: Anti–RNPC‐3 Antibodies As a Marker of Cancer‐Associated Scleroderma (2017) (54)
The Saccharomyces cerevisiae MEC1 gene, which encodes a homolog of the human ATM gene product, is required for G1 arrest following radiation treatment (1996) (54)
Reduced expression and impaired kinase activity of a Chk2 mutant identified in human lung cancer. (2001) (54)
Aneuploidy in Cancer: Seq-ing Answers to Old Questions (2017) (51)
Protein interaction discovery using parallel analysis of translated ORFs (PLATO) (2013) (51)
Genetic instability and mammary tumor formation in mice carrying mammary-specific disruption of Chk1 and p53 (2010) (50)
MAPK Pathway Suppression Unmasks Latent DNA Repair Defects and Confers a Chemical Synthetic Vulnerability in BRAF-, NRAS-, and NF1-Mutant Melanomas. (2019) (50)
A Serial shRNA Screen for Roadblocks to Reprogramming Identifies the Protein Modifier SUMO2 (2016) (49)
The SCF–ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkBa and b-catenin and stimulates IkBa ubiquitination in vitro (1999) (49)
Skipping into the E2F1-destruction pathway (1999) (49)
Sources of Error in Mammalian Genetic Screens (2016) (49)
Comprehensive Identification of Host Modulators of HIV-1 Replication using Multiple Orthologous RNAi Reagents (2014) (49)
Autoreactivity and Exceptional CDR Plasticity (but Not Unusual Polyspecificity) Hinder Elicitation of the Anti-HIV Antibody 4E10 (2013) (48)
The cellular chamber of doom. (2001) (48)
Profiling DNA damage-induced phosphorylation in budding yeast reveals diverse signaling networks (2016) (48)
Mrc1 phosphorylation in response to DNA replication stress is required for Mec1 accumulation at the stalled fork (2009) (48)
Phasmid vectors for identification of genes by complementation of Escherichia coli mutants (1985) (47)
Structural basis for antibody inhibition of flavivirus NS1–triggered endothelial dysfunction (2021) (47)
The adaptive immune system is a major driver of selection for tumor suppressor gene inactivation (2021) (46)
Bub2 Is a Cell Cycle Regulated Phospho-Protein Controlled by Multiple Checkpoints (2002) (45)
Application of a synthetic human proteome to autoantigen discovery through PhIP-Seq (2011) (42)
Genetic modifiers of the BRD4-NUT dependency of NUT midline carcinoma uncovers a synergism between BETis and CDK4/6is (2018) (42)
FACT Proteins, SUPT16H and SSRP1, Are Transcriptional Suppressors of HIV-1 and HTLV-1 That Facilitate Viral Latency* (2015) (41)
The DASH Complex Component Ask1 Is a Cell Cycle-Regulated Cdk Substrate in Saccharomyces cerevisiae (2003) (40)
Antibody responses to endemic coronaviruses modulate COVID-19 convalescent plasma functionality (2020) (40)
Genetic Analysis of the Kinetochore DASH Complex Reveals an Antagonistic Relationship with the Ras/Protein Kinase A Pathway and a Novel Subunit Required for Ask1 Association (2005) (40)
Integrated proteogenetic analysis reveals the landscape of a mitochondrial-autophagosome synapse during PARK2-dependent mitophagy (2019) (39)
Gene identification using the yeast two-hybrid system. (1996) (39)
Genetic selection for genes encoding sequence-specific DNA-binding proteins. (1989) (39)
Construction of a rationally designed antibody platform for sequencing-assisted selection (2012) (37)
Functional kinomics establishes a critical node of volume-sensitive cation-Cl− cotransporter regulation in the mammalian brain (2016) (37)
The two faces of BRCA2, a FANCtastic discovery. (2002) (37)
Cloning of the complete coding region for human protein phosphatase inhibitor 2 using the two hybrid system and expression of inhibitor 2 in E. coli (1994) (37)
Chlamydia trachomatis-induced alterations in the host cell proteome are required for intracellular growth. (2014) (36)
A Druggable Genome Screen Identifies Modifiers of α-Synuclein Levels via a Tiered Cross-Species Validation Approach (2018) (36)
Dissecting cancer pathways and vulnerabilities with RNAi. (2005) (35)
Rapid construction of recombinant DNA by the univector plasmid-fusion system. (2000) (34)
A family of vectors that facilitate transposon and insertional mutagenesis of cloned genes in yeast (1994) (32)
Gene targeting at the human CD4 locus by epitope addition. (1990) (31)
A role for the host coatomer and KDEL receptor in early vaccinia biogenesis (2009) (30)
An Open Letter to Elias Zerhouni (2005) (29)
NatB Domain-Containing CRA-1 Antagonizes Hydrolase ACER-1 Linking Acetyl-CoA Metabolism to the Initiation of Recombination during C. elegans Meiosis (2015) (29)
A Deregulated HOX Gene Axis Confers an Epigenetic Vulnerability in KRAS-Mutant Lung Cancers. (2020) (29)
Systematic characterization of mutations altering protein degradation in human cancers. (2021) (28)
p21 and p57 control muscle differentiation at the myogenin step (1999) (27)
Tiling genomes of pathogenic viruses identifies potent antiviral shRNAs and reveals a role for secondary structure in shRNA efficacy (2012) (26)
Ontogeny of Recognition Specificity and Functionality for the Broadly Neutralizing Anti-HIV Antibody 4E10 (2014) (26)
RNAi-based functional selection identifies novel cell migration determinants dependent on PI3K and AKT pathways (2014) (25)
Cell cycle: Mitotic treasures in the nucleolus (1999) (25)
Natural selection contributed to immunological differences between hunter-gatherers and agriculturalists (2018) (24)
Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program (2017) (24)
Durfee, T. et al. The Retinoblastoma protein associates with protein phosphatase type 1 catalytic subunit. Genes Dev. 7, 555-569 (1993) (23)
Troponin T is capable of binding dystrophin via a leucine zipper (1994) (23)
Antibody responses to endemic coronaviruses modulate COVID-19 convalescent plasma functionality. (2021) (21)
A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM–p53 signaling (2016) (21)
PAT1, an evolutionarily conserved acetyltransferase homologue, is required for multiple steps in the cell cycle (1996) (21)
Identification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing (2019) (20)
Regulation and functions of Escherichia coli genes induced by DNA damage. (1982) (20)
CARM1 Inhibition Enables Immunotherapy of Resistant Tumors by Dual Action on Tumor cells and T cells. (2021) (19)
Cloning Mammalian Genes Using cDNA Expression Libraries in Saccharomyces cerevisiae (1993) (19)
STOP gene Phactr4 is a tumor suppressor (2013) (18)
Mutagenesis and other responses induced by DNA damage in Escherichia coli. (1982) (18)
Comprehensive Profiling of HIV Antibody Evolution (2019) (18)
Purification and analysis of CIP/KIP proteins. (1997) (18)
Rapid mapping of antigenic coding regions and constructing insertion mutations in yeast genes by mini-Tn10 "transplason" mutagenesis. (1986) (17)
Coordinate regulation of the senescent state by selective autophagy. (2021) (17)
Analysis of budding yeast kinases controlled by DNA damage. (1997) (17)
Discovery of protein interactions using parallel analysis of translated ORFs (PLATO) (2013) (17)
An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity (2022) (17)
GLTSCR2/PICT1 links mitochondrial stress and Myc signaling (2014) (16)
The FHA domain, a phosphoamino acid binding domain involved in the DNA damage response pathway. (2000) (16)
CDK 2 encodes a 33-kDa cyclin A-associated protein kinase and is expressed before CDC 2 in the cell cycle ( cell cycle regulation / cyclins / threonine-serine protein kinase / phosphotyrosine ) (16)
ORF10–Cullin-2–ZYG11B complex is not required for SARS-CoV-2 infection (2021) (16)
Sensing and signaling DNA damage: roles of Rad17 and Rad9 complexes in the cellular response to DNA damage. (2001) (15)
Brief Report: VGLL4 Is a Novel Regulator of Survival in Human Embryonic Stem Cells (2013) (15)
An Open Letter to Cancer Researchers (2005) (14)
High-resolution epitope mapping by AllerScan reveals relationships between IgE and IgG repertoires during peanut oral immunotherapy (2021) (14)
required for self-renewal A genome-wide RNAi screen identifies a new transcriptional module Material (2009) (14)
Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks (2016) (13)
Temporal virus serological profiling of kidney graft recipients using VirScan (2019) (13)
Interspecies analysis of MYC targets identifies tRNA synthetases as mediators of growth and survival in MYC-overexpressing cells (2019) (12)
The DNA Damage Response--Self-awareness for DNA: The 2015 Albert Lasker Basic Medical Research Award. (2015) (12)
Identification of MSA1, a cell cycle-regulated, dosage suppressor of drc1/sld2 and dpb11 mutants (2008) (12)
Cancer: Deconstructing oncogenesis (2008) (11)
Dicer is essential for mouse development (2003) (11)
BRCA2 Enters the Fray (2002) (11)
Regulation and function of cellular gene products involved in UV and chemical mutagenesis in E. coli. (1983) (11)
2.5 Million Person-Years of Life Have Been Lost Due to COVID-19 in the United States (2020) (10)
BRCA1 as tumor suppressor: lord without its RING? (2012) (10)
Cell cycle: Conducting the mitotic symphony (2000) (10)
The Protexin complex counters resection on stalled forks to promote homologous recombination and crosslink repair. (2021) (10)
Empirical identification and validation of tumor-targeting T cell receptors from circulation using autologous pancreatic tumor organoids (2021) (10)
Genetic analysis of cancer drivers reveals cohesin and CTCF as suppressors of PD-L1 (2022) (9)
Aneuploidy Police Detect Chromosomal Imbalance Triggering Immune Crackdown! (2017) (9)
Robust dengue virus infection in bat cells and limited innate immune responses coupled with positive serology from bats in IndoMalaya and Australasia (2019) (9)
ATM – Chk 2 – p 53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca 1 deficiency (2013) (9)
Functional genomics reveals that tumors with activating phosphoinositide 3-kinase mutations are dependent on accelerated protein turnover (2016) (9)
High-Throughput Screening of Kawasaki Disease Sera for Antiviral Antibodies. (2020) (8)
Gain-of-function genetic screening identifies the antiviral function of TMEM120A via STING activation (2022) (8)
Comprehensive Virome-wide Antibody Responses by Systematic Epitope Scanning After Hematopoietic Cell Transplantation. (2019) (7)
Identification of potent inhibitors of SARS-CoV-2 infection by combined pharmacological evaluation and cellular network prioritization (2022) (7)
Regulatory Networks That Control DNA Damage-Inducible Genes in Saccharomyces cerevisiae (1998) (7)
umuDC and mucAB operons whose products are required for UV light- and chemical-induced mutagenesis: UmuD, MucA, and LexA proteins share homology. 1985. (2005) (7)
CRISPR-based peptide library display and programmable microarray self-assembly for rapid quantitative protein binding assays. (2021) (6)
Integrated loss- and gain-of-function screens define a core network governing human embryonic stem cell behavior (2021) (6)
proteins Systematic analysis and nomenclature of mammalian F-box data (2004) (6)
Cancer. BRCA2 enters the fray. (2002) (6)
Protein interaction mapping with ribosome-displayed using PLATO ORF libraries (2013) (5)
Abstract 3091: A sumoylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis (2012) (5)
17 – λgt 11: Gene Isolation with Antibody Probes and Other Applications (1989) (5)
Identification andIsolation oftheGeneEncoding theSmallSubunit ofRibonucleotide Reductase fromSaccharomyces cerevisiae: DNA Damage-Inducible GeneRequired forMitotic Viability (1987) (4)
Infection Through a Functional Genomic Screen Identification of Host Proteins Required for HIV (2008) (4)
Global Identification of Modular (2011) (4)
Turkey must end violent response to protests. (2013) (4)
SLIC sub-cloning using T4 DNA polymerase treated inserts without RecA (2007) (4)
V-CARMA: A tool for the detection and modification of antigen-specific T cells (2022) (4)
Diversified Application of Barcoded PLATO (PLATO-BC) Platform for Identification of Protein Interactions (2019) (4)
How the Cyclin Became a Minireview Cyclin: Regulated Proteolysis in the Cell Cycle (1999) (3)
Erratum: Global identification of modular cullin-ring ligase substrates (Cell (2011) 147 (459-475)) (2012) (3)
Taking the brakes off telomerase (2015) (3)
Erratum: Cross-talk between Chk1 and Chk2 in double-mutant thymocytes (Proceedings of the National Academy of Sciences of the United States of America (2007) 104, (3805-3810) DOI: 10.1073/pnas.0611584104) (2007) (3)
Faculty Opinions recommendation of Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways. (2002) (2)
Characterization of Torin 2 , an ATP-Competitive Inhibitor of mTOR , ATM , and ATR Citation (2013) (2)
E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity. (2023) (2)
A functional genomics approach to viral-host interactions for HIV (2010) (2)
Accidents and Damage Control (2015) (2)
Identification of druggable host targets needed for SARS-CoV-2 infection by combined pharmacological evaluation and cellular network directed prioritization both in vitro and in vivo (2022) (2)
VirScan: High-throughput Profiling of Antiviral Antibody Epitopes. (2022) (1)
Robust dengue virus infection in bat cells and limited innate immune responses coupled with positive serology from bats in IndoMalaya and Australasia (2019) (1)
The uncharacterized SANT and BTB domain-containing protein SANBR inhibits class switch recombination (2021) (1)
Cell biology forum: Genome-wide view of mitosis (2010) (1)
A role for PVRL 4-driven cell-cell interactions in tumorigenesis Citation (2013) (1)
Abstract 4366: ShRNA-based cellular proliferation signaling analysis revealed DRD2 as a novel therapeutic target for glioblastoma. (2013) (1)
When noise makes music: HIV reactivation with transcriptional noise enhancers (2014) (1)
CasPlay provides a gRNA-barcoded CRISPR-based display platform for antibody repertoire profiling (2022) (0)
Clonal expansion of personalized anti-tumor T cells from circulation using tumor organoid-immune co-cultures (2020) (0)
Reply (2017) (0)
Functional Genomics Cancer Proliferation Gene Discovery Through (2010) (0)
Brief Reports on All Topics (1981) (0)
Abstract PR2: A genetic screen for novel determinants of anoikis resistance identifies PVRL4 (2011) (0)
BRCA1 as tumor suppressor: lord without its RING? (2012) (0)
Abstract 2404: Cumulative dosage effect of TSGs and OGs drives aneuploidy patterns in cancer (2014) (0)
Gain-of-function genetic screening identifies the antiviral function of TMEM120A via STING activation (2022) (0)
High-Affinity PD-1 Protein Has Potential. (2015) (0)
REGULATION AND FUNCTIONS OF Escherichia coli GENES (1982) (0)
Identification and characterization of genes involved in mutagenesis in Escherichia coli (1983) (0)
Abstract 1358: Discovery and optimization of potent and selective benzonaphthyridinone analogs as dual mTOR/ATR small molecular inhibitors for treatment of cancer (2011) (0)
News in brief … (1997) (0)
100 and 50 years ago (2000) (0)
Correction for Zirin et al., Interspecies analysis of MYC targets identifies tRNA synthetases as mediators of growth and survival in MYC-overexpressing cells (2019) (0)
Genetic selection for genes encoding sequence-specific (2016) (0)
Development of General Methods for Identification of Genes Regulated by Oncogenic Stimuli or DNA Damage (2001) (0)
Top scoring 4E10 and b12 PhIP-Seq 36-mer peptides. (2013) (0)
Ronald R. Tasker Young Investigator Award 165 Promoting Endogenous GABAergic Analgesia via Kinase Modulation of Neuronal Ion Plasticity. (2014) (0)
ATM , and ATR Characterization of Torin 2 , an ATP-Competitive Inhibitor of mTOR (2013) (0)
Proliferative Potential Recurrent Hemizygous Deletions in Cancers May Optimize (2012) (0)
Genomic Approaches for Detection and Treatment of Breast Cancer (2005) (0)
Sequencer Hacking Unlocks Quantitative Protein Studies. (2019) (0)
mTOR , ATM and ATR Characterization of Torin 2 , an ATP-competitive inhibitor of (2013) (0)
Unbiased Screening of Kawasaki Disease Sera for Viral Antigen Exposure (2017) (0)
The Role of Ckh2 in Breast Cancer (2003) (0)
Puck Knipscheer Interstrand Cross-Link Repair The Fanconi Anemia Pathway Promotes Replication-Dependent DNA (2014) (0)
Abstract LB-113: MAPK pathway suppression unmasks latent DNA repair defects and confers a chemical synthetic vulnerability inBRAF,NRASandNF1-mutant melanomas (2019) (0)
Functional properties of an ensemble of candidate germline-encoded precursors of the anti-MPER antibody 4E10 (2012) (0)
Cdk2: cyclin-dependent kinase 2 (vertebrates) (1995) (0)
When noise makes music: HIV reactivation with transcriptional noise enhancers (2014) (0)
58 Proffered Paper: Next Generation RNAi Mouse Models for Drug Discovery and Toxicology Assessment (2012) (0)
Abstracts of papers presented at the 2002 Meeting on the Cell Cycle, May 15-May19, 2002 (2002) (0)
Sa1548 – Investigations Into Viral Etiology of Primary Sclerosing Cholangitis: No Smoking Gun Identified (2019) (0)
Identification of Genes Required for the Survival of BRCA 1-/- Cells (2011) (0)
DNA Damage and Cell Cycle Regulation in S. Cerevisiae (1994) (0)
Using Genetics and Genomics for the Detection and Treatment of Breast Cancer (2009) (0)
Checkpoint signaling and protein degradation (2007) (0)
Faculty Opinions recommendation of Inheritance of a cancer-associated MLH1 germ-line epimutation. (2007) (0)
proteinsanalysis and nomenclature of mammalian F-box (2006) (0)
A GATA4-regulated secretory program suppresses tumors through recruitment of cytotoxic CD8 T cells (2022) (0)
An Editor's rave review (2023) (0)
Faculty of 1000 evaluation for A primer on using pooled shRNA libraries for functional genomic screens. (2012) (0)
The BRCT Domain Is a Phospho-Protein Binding Domain (2003) (0)
Reply to “Understanding the role of antibodies as markers of cancer coexistence in systemic sclerosis” by Bernal-Bello et al. (2017) (0)
Abstract IA28: Haploinsufficiency in cancer (2013) (0)
Abstract IA8: Genetic approaches to cancer (2012) (0)
Role of KIP2 in Breast Cancer (1998) (0)
The evolution of human cells into malignant derivatives is driven by the aberrant function of genes that positively and negatively regulate various aspects of the cancer phenotype, including altered responses to mitogenic and cytostatic signals, resistance to programmed cell death, (2009) (0)
The 2013 Gairdner Foundation International Award winners The Canada Gairdner Foundation announced their 2013 International Award winners on March 20. Five researchers have been selected for the prestigious prize. Dara Mohammadi reports. (2013) (0)
Correction (1993) (0)
Abstract S6-10: Identification of a Novel Tumor Suppressor Network Reveals a Role for Proto-Oncogenic Receptor Tyrosine Kinases in Triple-Negative Breast Cancer (2010) (0)
SLIC sub-cloning using iPCR or mixed PCR products (2007) (0)
Abstract SY25-03: Haploinsufficiency in cancer: When half simply isn't good enough. (2013) (0)
Biological and Biomedical Sciences 230: Analysis of the Biological Literature (2013) (0)
Abstract 1964: Genetic instability and mammary tumor formation in mice carrying mammary-specific disruption of Chk1 (2010) (0)
Therapeutics , Targets , and Chemical Biology Characterization of Torin 2 , an ATP-Competitive Inhibitor of mTOR , ATM , and ATR (2013) (0)
The influence of the lung virome on pulmonary B cells (2019) (0)
Some Like It Sweet: Dendritic Cells Add Sugar to Their T(ea) (2020) (0)
Abstract A33: A whole genome RNAi screen identifies BRD7 and BAF180 as p53 regulators required for senescence (2011) (0)
Corrigendum: Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program. (2017) (0)
Abstract P6-11-01: A broad spectrum therapeutic strategy for TNBC revealed by a new pathway that coordinates oncogenic RTKs (2015) (0)
Imprinting ofthegeneencoding ahumancyclin-dependent kinase inhibitor, p57KIP2 on chromosomellpl5 SHUHEIMATSUOKA*tt, JEFFREY S.THOMPSONt§, MICHAELC.EDWARDS¶, JANETM.BARLETTA§, PAULGRUNDYII, (1996) (0)
ATM-Independent Manner Mutated (ATM)-Dependent and an Apoptosis in both an Ataxia Telangiectasia Chk2 Is a Tumor Suppressor That Regulates (2014) (0)
Abstract SY36-03: How aneuploidy drives tumorigenesis (2014) (0)
Abstract 1318: Proteasome and Fanconi Anemia/BRCA pathways as prognostic determinants of glioblastoma response to radiation and temozolomide: a proposed clinical trial (2010) (0)
Abstract IA17: The role of the senescence-associated secretory phenotype in cancer (2021) (0)
Analysis of the DNA Damage Signaling Network Important for Prevention of Breast Cancer (2004) (0)
United States Patent ( 10 ) Patent No . : US 6 , 828 , 093 B 1 (2017) (0)
Abstract B09: Combining proteomics and genetic screens to identify KRAS synthetic lethal interactions (2020) (0)
In Vivo Interactions p57 KIP2 Inhibitor: Cooperative Cyclin D- and E-Dependent Kinases and the (2013) (0)
Rapid iPSC inclusionopathy models shed light on formation, consequence and molecular subtype of α-synuclein inclusions (2022) (0)
Faculty Opinions recommendation of Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. (2005) (0)
A GATA4-regulated secretory program suppresses tumors through recruitment of cytotoxic CD8 T cells (2022) (0)
Advances in Brief WAF 1 / CIP 1 Is Induced in / ? 53-mediated G ! Arrest and Apoptosis 1 (2006) (0)
A central role for regulated protein stability in the control of TFE3 and MITF by nutrients. (2023) (0)
Identificaton of Genes Required for the Survival of Prostate Cancer Cells (2010) (0)
KIAA1841, a novel SANT and BTB domain-containing protein, inhibits class switch recombination (2020) (0)
Cell-Cycle and DNA-Damage Regulation of Ribonucleotide Reductase (2020) (0)
Methods Preparation of Proteins and Antibodies Puri®cation of Pid from Nuclear Extracts P53 Deacetylation Assay (0)
Abstract SY10-01: How aneuploidy drives cancer (2016) (0)

This paper list is powered by the following services:

Other Resources About Stephen Elledge

What Schools Are Affiliated With Stephen Elledge?

Stephen Elledge is affiliated with the following schools:

Stephen Elledge's Academic­Influence.com Rankings