Stephen Hanessian
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Canadian chemist
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Chemistry
Why Is Stephen Hanessian Influential?
(Suggest an Edit or Addition)According to Wikipedia, Stephen Hanessian, OC, FRSC, is a chemist and professor of Canadian and United States citizenship born in Alexandria, Egypt. His research group at Université de Montréal is well known for developing synthetic methodologies, as well as natural product total synthesis. In addition, his group developed Chiron, a computer program used by organic chemists for synthetic planning.
Stephen Hanessian's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Total synthesis of natural products, the "Chiron" approach (1983) (613)
- Design and synthesis of conformationally constrained amino acids as versatile scaffolds and peptide mimetics (1997) (484)
- Regioselective manipulation of hydroxyl groups via organotin derivatives (1985) (479)
- Preparative carbohydrate chemistry (1997) (411)
- The Preparation and Synthetic Utility of tert-Butyldiphenylsilyl Ethers (1975) (368)
- Analysis of trimethylsilyl derivatives of carbohydrates by gas chromatography and mass spectrometry (1969) (360)
- trans-1,2-Diaminocyclohexane Derivatives as Chiral Reagents, Scaffolds, and Ligands for Catalysis: Applications in Asymmetric Synthesis and Molecular Recognition. (1997) (293)
- Catalytic asymmetric conjugate addition of nitroalkanes to cycloalkenones. (2000) (232)
- Design of Secondary Structures in Unnatural Peptides: Stable Helical γ-Tetra-, Hexa-, and Octapeptides and Consequences of α-Substitution (1998) (200)
- Synthesis of naturally occurring C-nucleosides, their analogs, and functionalized C-glycosyl precursors. (1976) (194)
- Synthetic Strategies toward Natural Products Containing Contiguous Stereogenic Quaternary Carbon Atoms. (2016) (193)
- Reaction of O-benzylidene sugars with N-bromosuccinimide. II. Scope and synthetic utility in the methyl 4,6-0-benzylidenehexopyranoside series (1969) (184)
- Neuronal activity‐dependent increase of net matrix metalloproteinase activity is associated with MMP‐9 neurotoxicity after kainate (2003) (181)
- The Reaction of Free Carbonyl Sugar Derivatives with Organometallic Reagents. I. 6-Deoxy-L-idose and Derivatives1,2 (1962) (167)
- Procedures for the direct replacement of primary hydroxyl groups in carbohydrates by halogen (1972) (155)
- Chemistry and biology of the aeruginosin family of serine protease inhibitors. (2008) (152)
- Synthesis of (4S)-hydroxymethyl-(2R)-(2-propyl)-butyrolactone: A quest for a practical route to an important hydroxyethylene isostere chiron (1997) (149)
- Chemistry of the glycosidic linkage. An efficient synthesis of 1,2-trans-di-saccharides (1977) (144)
- Additions and Corrections - Design and Reactivity of Topologically Unique, Chiral Phosphonamides. Remarkable Diastereofacial Selectivity in Asymmetric Olefination and Alkylation. (1984) (124)
- Matrix metalloproteinase‐2 (MMP‐2) regulates astrocyte motility in connection with the actin cytoskeleton and integrins (2006) (118)
- The reaction of O-benzylidene sugars with N-bromosuccinimide (1966) (116)
- Stereocontrolled glycosyl transfer reactions with unprotected glycosyl donors. (2000) (113)
- Molecular Recognition and Self-Assembly by Non-amidic Hydrogen Bonding. An Exceptional Assembler of Neutral and Charged Supramolecular Structures (1995) (106)
- The total synthesis of (+)-ionomycin (1990) (98)
- Isolation and characterization of antigenic components of a new heptavalent Pseudomonas vaccine. (1971) (97)
- The N-acyloxyiminium ion aza-Prins route to octahydroindoles: total synthesis and structural confirmation of the antithrombotic marine natural product oscillarin. (2004) (96)
- Docking of aminoglycosides to hydrated and flexible RNA. (2006) (94)
- Chemistry of the glycosidic linkage. Exceptionally fast and efficient formation of glycosides by remote activation (1980) (93)
- Antibacterial aminoglycosides with a modified mode of binding to the ribosomal-RNA decoding site. (2004) (91)
- Recent Progress in the Chemistry of Daphniphyllum Alkaloids †. (2017) (91)
- Efficient allyl to propenyl isomerization in functionally diverse compounds with a thermally modified Grubbs second-generation catalyst. (2006) (89)
- Synthesis of (+)-avermectin B1a (1986) (84)
- Facile access to (S)-1,2,4-butanetriol and its derivatives (1984) (81)
- The practice of ring constraint in peptidomimetics using bicyclic and polycyclic amino acids. (2008) (80)
- THE SYNTHESIS OF FUNCTIONALIZED CYCLODEXTRINS AS SCAFFOLDS AND TEMPLATES FOR MOLECULAR DIVERSITY, CATALYSIS, AND INCLUSION PHENOMENA (1995) (80)
- Mild cleavage of methoxymethyl (MOM) ethers with trimethylsilyl bromide (1984) (79)
- Stereochemical control of nature's biosynthetic pathways:A general strategy for the synthesis 0f polypropionate-derived structural units from a single chiral progenitor (1987) (79)
- Synthesis of functionally diverse bicyclic sulfonamides as constrained proline analogues and application to the design of potential thrombin inhibitors (2003) (79)
- MOLECULAR RECOGNITION AND SELF-ASSEMBLY BY WEAK HYDROGEN BONDING : UNPRECEDENTED SUPRAMOLECULAR HELICATE STRUCTURES FROM DIAMINE/DIOL MOTIFS (1994) (77)
- A versatile asymmetric synthesis of α-amino α-alkyl-phosphonic acids of high enantiomeric purity (1990) (76)
- Approaches to the total synthesis of natural products using "chiral templates" derived from carbohydrates (1979) (76)
- Reaction of O-benzylidene sugars with N-bromosuccinimide. III. Applications to the synthesis of aminodeoxy and deoxy sugars of biological importance (1969) (74)
- A stereospecifie, total synthesis of thromboxane B2 (1977) (74)
- The stereocontrolled formation of cyclic vicinal cis-diols via a samarium diiodide pinacol coupling of dialdehydes (1991) (73)
- Design and reactivity of organic functional groups: imidazolylsulfonate (imidazylate) - au efficient and versatile leaving group (1981) (71)
- Total synthesis of A-315675: a potent inhibitor of influenza neuraminidase. (2002) (70)
- Total synthesis and structural confirmation of the marine natural product Dysinosin A: a novel inhibitor of thrombin and Factor VIIa. (2002) (70)
- Total synthesis of pactamycin. (2011) (68)
- Solution and solid phase synthesis of 5-alkoxyhydantoin libraries with a three-fold functional diversity (1996) (67)
- A novel and efficient synthesis of L-vinylglycine (1984) (66)
- Chemistry of the glycosidic linkage. Direct conversion of glycosides into 1-thioglycosides by use of [alkyl(or aryl)thio]trimethylsilanes (1980) (66)
- The Iterative Synthesis of Acyclic Deoxypropionate Units and Their Implication in Polyketide-Derived Natural Products (2006) (65)
- Chemistry of the glycosidic linkage.O-glycosylations catalyzed by stannic chloride, in the D-ribofuranose and D-glucopyranose series (1977) (65)
- STRUCTURAL STUDIES ON STAPHYLOCOCCAL POLYSACCHARIDE ANTIGEN. (1964) (65)
- Polymer-bound p-alkoxybenzyl trichloracetimidates: Reagents for the protection of alcohols as benzyl ethers on solid-phase (1998) (64)
- Facile Cleavage of Benzyl Ethers by Catalytic Transfer Hydrogenation (1981) (63)
- Synthesis and antitumor activity of 4'-deoxydaunorubicin and 4'-deoxyadriamycin. (1976) (62)
- Total synthesis of biologically important amino sugars via thenitroaldol reaction (1985) (62)
- The asymmetric synthesis of allylglycine and other unnatural α-amino acids via zinc-mediated allylation of oximes in aqueous media (1996) (61)
- The asymmetric synthesis of α-chloro α-alkyl and α-methyl α-alkyl phosphonic acids of high enantiomeric purity. (1990) (60)
- Synthesis and folding preferences of γ-amino acid oligopeptides: stereochemical control in the formation of a reverse turn and a helix (1999) (60)
- Selected Methods of Oxidation in Carbohydrate Chemistry (1971) (60)
- Asymmetric Synthesis of Enantiomerically Pure and Diversely Functionalized Cyclopropanes. (1995) (60)
- Stereocontrolled synthesis of the spiro ketal unit of avermectin B1a aglycon (1983) (60)
- Total Synthesis of (-)-Tetrahydrolipstatin (1993) (60)
- Non-natural macrocyclic inhibitors of histone deacetylases: design, synthesis, and activity. (2010) (59)
- Structure-based design, synthesis, and memapsin 2 (BACE) inhibitory activity of carbocyclic and heterocyclic peptidomimetics. (2005) (58)
- Application of conformation design in acyclic stereoselection: total synthesis of borrelidin as the crystalline benzene solvate. (2003) (58)
- Stereoselective Synthesis of (−)-α-Kainic Acid and (+)-α-Allokainic Acid via Trimethylstannyl-Mediated Radical Carbocyclization and Oxidative Destannylation (1996) (56)
- Optimization of the catalytic asymmetric addition of nitroalkanes to cyclic enones with trans-4,5-methano-L-proline. (2006) (55)
- Total synthesis and structural confirmation of chlorodysinosin A. (2006) (55)
- Progress in natural product chemistry by the chiron and related approaches - synthesis of avermectin B1a (1987) (54)
- A method for induced-fit docking, scoring, and ranking of flexible ligands. Application to peptidic and pseudopeptidic beta-secretase (BACE 1) inhibitors. (2006) (54)
- Reaction of O-benzylidene sugars with N-bromosuccinimide. IV. Neighboring-group effects and rearrangements (1969) (54)
- A NEW SYNTHETIC STRATEGY FOR THE PENEMS. TOTAL SYNTHESIS OF (5R,6S,8R)-6-(α-HYDROXYETHYL)-2-(HYDROXYMETHYL)PENEM-3-CARBOXYLIC ACID (1985) (54)
- Catalysis of the Hajos—Parrish—Eder—Sauer—Wiechert Reaction by cis‐ and trans‐4,5‐Methanoprolines: Sensitivity of Proline Catalysis to Pyrrolidine Ring Conformation (2004) (53)
- Reagents for organic synthesis: use of organostannyl oxides as catalytic neutral esterification agents in the preparation of macrolides (1980) (53)
- Structure-based design and synthesis of macroheterocyclic peptidomimetic inhibitors of the aspartic protease beta-site amyloid precursor protein cleaving enzyme (BACE). (2006) (53)
- The psychobiological basis of heuristic synthesis planning - man, machine and the chiron approach (1990) (53)
- Asymmetric dihydroxylation of olefins with a simple chiral ligand (1993) (52)
- Total synthesis of bafilomycin A(1) relying on iterative 1,2-induction in acyclic precursors. (2001) (52)
- 1,3-Asymmetric induction in dianionic allylation reactions of amino acid derivatives-synthesis of functionally useful enantiopure glutamates, pipecolates and pyroglutamates (1998) (51)
- Reactions of carbohydrates with (halomethylene)dimethyliminium halides and related reagents. Synthesis of some chlorodeoxy sugars (1969) (51)
- A versatile protocol for the stereocontrolled elaboration of vicinal secondary and tertiary centers of relevance to natural product synthesis (1987) (51)
- The asymmetric synthesis of α-substituted α-methyl and α-phenyl phosphonic acids: Design, carbanion geometry, reactivity and preparative aspects of chiral alkyl bicyclic phosphonamides (1996) (51)
- Hydrogen-Bonding as a Stereocontrolling Element in Free-Radical C-Allylation Reactions: Vicinal, Proximal, and Remote Asymmetric Induction in the Amino Acid Series (1996) (51)
- Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways. (2016) (49)
- Strategien für die Synthese von Naturstoffen mit benachbarten stereogenen quartären Kohlenstoffatomen (2016) (49)
- Total Synthesis of Isodaphlongamine H: A Possible Biogenetic Conundrum. (2016) (48)
- Expedient assembly of carbocyclic, heterocyclic, and polycyclic compounds by trimethylstannyl radical mediated carbocyclizations of dienes and trienes: a novel oxidative cleavage of the carbon-tin bond (1992) (48)
- Asymmetric conjugate additions of chiral allyl- and crotylphosphonamide anions to .alpha.,.beta.-unsaturated carbonyl compounds: highly stereocontrolled access to vicinally substituted carbon centers and chemically asymmetrized chirons (1993) (48)
- A novel ring-closure strategy for the carbapenems: the total synthesis of (+)-thienamycin (1990) (47)
- Formation of C-glycosides by polarity inversion at the anomeric centre (1986) (46)
- Synthetic Studies on the Mevinic Acids Using the Chiron Approach: Total Synthesis of (+)-Dihydromevinolin." (1990) (45)
- Synthesis of chemically functionalized superparamagnetic nanoparticles as delivery vectors for chemotherapeutic drugs. (2008) (45)
- Cyclic enaminones. Part II: applications as versatile intermediates in alkaloid synthesis. (2015) (45)
- Design and synthesis of a cephalosporin–carboplatinum prodrug activatable by a β-lactamase (1993) (44)
- Total synthesis and stereochemical confirmation of manassantin A, B, and B1. (2006) (44)
- Studies in asymmetric olefinations — the synthesis of enantiomerically pure allylidene, alkylidene, and benzylidene cyclohexanes (1992) (44)
- Design and synthesis of matrix metalloproteinase inhibitors guided by molecular modeling. Picking the S(1) pocket using conformationally constrained inhibitors. (2001) (44)
- Synthesis of diversely functionalized indolizidinones and related bicyclic lactams using intramolecular Grubbs olefin metathesis and Dieckmann condensation. (2003) (43)
- Novel access to (3R)- and (3S)-3-hydroxy-L-aspartic acids, (4S)-4-hydroxy- L-glutamic acid, and related amino acids (1993) (43)
- A novel synthetic route to the hexahydrobenzofuran subunit of the avermectins and milbemycins (1986) (43)
- N-Aryl sulfonyl homocysteine hydroxamate inhibitors of matrix metalloproteinases: further probing of the S(1), S(1)', and S(2)' pockets. (2001) (42)
- Structure-Based Design, Synthesis, and A-Site rRNA Cocrystal Complexes of Functionally Novel Aminoglycoside Antibiotics: C2'' Ether Analogues of Paromomycin (2007) (41)
- Surface‐Functionalized Ultrasmall Superparamagnetic Nanoparticles as Magnetic Delivery Vectors for Camptothecin (2009) (41)
- On the stereochemical divergence in the conjugate addition of lithium dimethylcuprate/trimethylsilyl chloride to γ-alkoxy and γ-ureido α,β-unsaturated esters (1991) (41)
- Total Synthesis of (-)-Reserpine Using the Chiron Approach. (1997) (41)
- The Synthesis of Enantiopure ω‐Methanoprolines and ω‐Methanopipecolic Acids by a Novel Cyclopropanation Reaction: The “Flattering” of Proline (1997) (41)
- A tactically novel alternative to acyclic stereoselection based on the concept of a replicating chiron — 1,3- and 1,4-C-Methyl substitution (1985) (41)
- Total synthesis of pactamycin and pactamycate: a detailed account. (2012) (41)
- Enantioselective allylation of α-ketoester oximes with an external chiral ligand: Asymmetric synthesis of allylglycines and allylalanine (1996) (41)
- Synthesis of (+)-spectinomycin (1979) (41)
- Synthesis of carbocycles from ω-substituted α,β-unsaturated esters via radical-induced cyclizations (1987) (41)
- Synthesis of a Bromine-Rich Marine Antibiotic (1966) (41)
- Total synthesis of jerangolid A. (2010) (40)
- Studies on the deconjugation−epimerization strategy en route to avermectin B1a: problems and solutions (1987) (40)
- Stereocontrolled Total Synthesis of an Annonacin A-Type Acetogenin: Pseudoannonacin A?† (1998) (39)
- Total synthesis of (+)-polyoximic acid - cis-3-ethylidene-L-azetidine-2-carboxylic acid (1993) (39)
- Generation of functional diversity via nitroaldol condensations of α-aminoacid aldehydes — A new and stereocontrolled route to acyclic 1,3-diamino-2-alcohols (1996) (39)
- Chemistry of spectinomycin: its total synthesis, stereocontrolled rearrangement, and analogs (1985) (39)
- A practical synthesis of 2-deoxy aldonolactones via a SmI2-mediated α-deoxygenation reaction (1992) (39)
- The synthesis of substituted lactones by intramolecular chirality transfer with stereodifferentiating chiral .alpha.-ester radical intermediates (1990) (39)
- Cleavage of methyl and benzyl ethers with thiotrimethylsilanes (1980) (39)
- Total synthesis of (+)-ambruticin S: probing the pharmacophoric subunit. (2010) (39)
- Targeting thrombin and factor VIIa: design, synthesis, and inhibitory activity of functionally relevant indolizidinones. (2002) (39)
- Synthesis of 5-Acetamido-5-deoxypentoses. Sugar Derivatives Containing Nitrogen in the Ring1 (1963) (38)
- Total synthesis of N-malayamycin A and related bicyclic purine and pyrimidine nucleosides. (2005) (38)
- Total synthesis and structural confirmation of malayamycin A: a novel bicyclic C-nucleoside from Streptomyces malaysiensis. (2003) (37)
- Carbohydrates as chiral intermediates in organic synthesis. Two functionalized chemical precursors comprising eight of the ten chiral centers of erythronolide A (1977) (37)
- Stereocontrolled glycosidation of daunomycinone. Synthesis and biological evaluation of 6-hydroxy-L-arabino analogues of antitumor anthracyclines. (1976) (37)
- Sugar lactams. III. Synthesis of five-,six-, and seven-membered analogs (1969) (37)
- Crystal Structure of the Bacterial Ribosomal Decoding Site Complexed with a Synthetic Doubly Functionalized Paromomycin Derivative: a New Specific Binding Mode to an A‐Minor Motif Enhances in vitro Antibacterial Activity (2007) (36)
- Constrained azacyclic analogues of the immunomodulatory agent FTY720 as molecular probes for sphingosine 1-phosphate receptors. (2007) (36)
- One-Step, Stereocontrolled Synthesis of Glycosyl 1-Phosphates, Uridine-5‘-diphosphogalactose, and Uridine-5‘-diphosphoglucose from Unprotected Glycosyl Donors (1998) (36)
- A versatile synthesis of a β-turn peptidomimetic scaffold: An approach towards a designed model antagonist of the tachykinin NK-2 receptor (1996) (36)
- CHARACTERIZATION OF AMINO SUGARS BY MASS SPECTROMETRY. (1965) (36)
- Reflections on the total synthesis of natural products: Art, craft, logic, and the chiron approach (1993) (35)
- Tobramycin analogues with C-5 aminoalkyl ether chains intended to mimic rings III and IV of paromomycin (2003) (35)
- The synthesis of enantiomerically pure, symmetrically substituted cyclopropane phosphonic acids — A constrained analog of the GABA antagonist phaclophen (1997) (35)
- Structure-based design, synthesis and A-site rRNA co-crystal complexes of novel amphiphilic aminoglycoside antibiotics with new binding modes: a synergistic hydrophobic effect against resistant bacteria. (2010) (35)
- Synthetic studies in the intramolecular carbocyclization of N-acyloxyiminium ions. Stereoelectronic and steric implications of nucleophilic alkene, alkyne, and allene tethers. (2005) (35)
- Electrophilic Amination and Azidation of Chiral α-Alkyl Phosphonamides: Asymmetric Syntheses of α-Amino α-Alkyl Phosphonic Acids† (1994) (35)
- The power of visual imagery in drug design. Isopavines as a new class of morphinomimetics and their human opioid receptor binding activity. (2003) (35)
- Synthesis of Hydroxamic Esters via Alkoxyaminocarbonylation of β-Dicarbonyl Compounds (1999) (34)
- Cyclic enaminones. Part I: stereocontrolled synthesis using diastereoselective and catalytic asymmetric methods. (2015) (34)
- A Novel Asymmetric Synthesis of a- and -Amino Aryl Phosphonic Acids (1993) (34)
- Heteroatom-assisted substitution of acyclic secondary tosylates with lithium dialkylcuprates. An expedient route to stereochemically defined deoxypropionate and related biosynthetic subunits (1989) (34)
- Asymmetric Conjugate Additions of Chiral Phosphonamide Anions to α,β-Unsaturated Carbonyl Compounds. A Versatile Method for Vicinally Substituted Chirons (2000) (34)
- Assembly of the carbon skeletal framework of erythronolide A (1978) (33)
- Design, modeling and synthesis of functionalized paromamine analogs (2001) (33)
- Structure‐Based Organic Synthesis of Drug Prototypes: A Personal Odyssey (2006) (33)
- Synthesis of 6-amino-6-deoxy- , -trehalose: a positional isomer of trehalosamine. (1972) (32)
- Synthesis of surrogate structures related to the herbicidal agent hydantocidin (1995) (32)
- Novel methods for the preparation of partially acetylated carbohydrates (1990) (32)
- Total synthesis of "aliskiren": the first Renin inhibitor in clinical practice for hypertension. (2010) (32)
- Supramolecular Chirons Based on Enantiodifferentiating Self‐Assembly between Amines and Alcohols (Supraminols) (1999) (31)
- Selective substitution reactions of α,α-trehalose: preparation of 6-monofunctional derivatives☆ (1973) (31)
- Carbanions in Carbohydrate Chemistry: Synthesis of C-Glycosyl Malonates (1974) (31)
- A method for the selective bromination of primary alcohol groups (1971) (31)
- Probing the importance of spacial and conformational domains in captopril analogs for angiotensin converting enzyme activity. (1998) (31)
- Chemistry of .alpha.-alkoxy sulfoxides. Formation of methylene acetals from dimethyl sulfoxide and alcohols (1972) (30)
- Total synthesis of oidiodendrolides and related norditerpene dilactones from a common precursor: metabolites CJ-14,445, LL-Z1271gamma, oidiolactones A, B, C, and D, and nagilactone F. (2009) (30)
- Practical syntheses of B disaccharide and linear B type 2 trisaccharide—non-primate epitope markers recognized by human anti-α-Gal antibodies causing hyperacute rejection of xenotransplants (2001) (30)
- Mass spectrometric studies on aminocyclitol antibiotics. (1967) (30)
- A tactically novel alternative to acyclic stereoselection based on the concept of a replicating chiron — access to 1,3-polyols (1985) (30)
- "Quantamycin" - a computer-simulated new-generation inhibitor of bacterial ribosomal binding (1984) (30)
- Highly stereoselective free radical C-6-allylation of penams - synthesis of a noval β-lactamase inhibitor (1989) (30)
- A General and Stereocontrolled Strategy for the Iterative Assembly of Enantiopure Polypropionate Subunits: Synthesis of the C19−C28 Segment of Rifamycin S from a Single Chiron (1997) (29)
- Carbanions in Carbohydrate Chemistry: Approaches to Chemical Precursors of C-Nucleosides (1974) (29)
- Stereocontrolled access to the octosyl acids - total synthesis of octosyl acid A (1986) (29)
- Zinc-Mediated Allylation of N-Protected α-Amino Aldehydes in Aqueous Solution. Stereoselective Synthesis of Phe-Phe Hydroxyethylene Dipeptide Isosteres (1997) (29)
- Oxidation of Alcohols with N-Halosuccinimides-New and Efficient Variants (1981) (29)
- Structure-based organic synthesis of unnatural aeruginosin hybrids as potent inhibitors of thrombin. (2007) (29)
- Total synthesis and structural confirmation of (+)-longicin. (2005) (29)
- The power of visual imagery in synthesis planning. Stereocontrolled approaches to CGP-60536B, a potent renin inhibitor. (2002) (29)
- Further evidence on the structure of cordycepin. (1966) (29)
- Synthesis and stereochemical confirmation of the secoiridoid glucosides nudiflosides D and A. (2006) (28)
- Methodoloy for the polyene and related antibiotics - enantiospecific synthesis of chiral structural units of amphotericin B from A common progenitor: the C14–C20 and C32–C38 segments (1987) (28)
- Total synthesis of tricyclic ?-lactams (1999) (28)
- STEREOCONTROLLED FUNCTIONALIZATION IN ACYCLIC SYSTEMS BY EXPLOITING INTERNAL 1,2-ASYMMETRIC INDUCTION-GENERATION OF POLYPROPIONATE AND RELATED MOTIFS (1996) (28)
- Approaches to the total synthesis of natural products from carbohydrates (1977) (28)
- Asymmetric synthesis of L-azetidine-2-carboxylic acid and 3-substituted congeners--conformationally constrained analogs of phenylalanine, naphthylalanine, and leucine. (1999) (28)
- Inhibition of Aminoglycoside‐Deactivating Enzymes APH(3′)‐IIIa and AAC(6′)‐Ii by Amphiphilic Paromomycin O2′′‐Ether Analogues (2011) (28)
- Design and reactivity of organic functional groups - preparation and nucleophilic displacement reactions of imidazole-1-sulfonates (imidazylates) (1996) (28)
- Studies directed toward the total synthesis of the ezomycins, the octosyl acids and related antibiotics (1981) (28)
- Synthesis of a chiral 1,7-dioxaspiro[5,5]undecene. A model for the spiroacetal subunit of avermectin B1a (1984) (27)
- Total synthesis and stereochemical identity of the C18H32O5 degradation product from boromycin (1981) (27)
- A mild and stereospecific conversion of vicinal diols into olefins (1978) (27)
- Selective hydrolysis of amide bonds in acetamido deoxy sugars. O-ethyl acetamidium fluoroborates. (1967) (27)
- Exploring the chiral space within the active site of alpha-thrombin with a constrained mimic of D-Phe-Pro-Arg--design, synthesis, inhibitory activity, and X-ray structure of an enzyme-inhibitor complex. (2000) (27)
- Design and synthesis of a prototypical non-peptidic inhibitor model for the enzme renin (1994) (27)
- Synthesis of carbohydrate phostones as potential glycomimetics (1994) (27)
- A highly stereocontrolled and efficient synthesis of α- and β-pseudouridines (2003) (26)
- Total synthesis of (+)-meroquinene (1990) (26)
- Omega-alkoxy analogues of SAHA (vorinostat) as inhibitors of HDAC: a study of chain-length and stereochemical dependence. (2007) (26)
- Natural products in medicinal chemistry (2014) (26)
- Aminoglycoside antibiotics: Chemical conversion of neomycin B, paromomycin, and lividomycin B into bioactive pseudosaccharides (1978) (25)
- Total synthesis of (+)-thromboxane B2 from D-glucose. A detailed account (1981) (25)
- Chemistry and Synthetic Utility of α-(Dimethylamino)benzylidene and 1-(Dimethylamino)ethylidene Acetals (1972) (25)
- Stereocontrolled Access to all-trans α,β,γ-Substituted Pyrrolidinones and Pyrrolidines of High Optical Purity from D-Pyroglutamic Acid (1990) (25)
- Probing the "additive effect" in the proline and proline hydroxamic acid catalyzed asymmetric addition of nitroalkanes to cyclic enones. (2005) (25)
- The synthesis of enantiomerically pure disubstituted aziridines and N -alkoxy aziridines (2000) (25)
- Stereocontrolled sequential functionalization in acyclic systems by exploiting internal 1,2-asymmetric induction — generation of symmetry-related polyamino alcohol motifs (1996) (25)
- Tandem functionalization of nonactivated alkenes and alkynes in intramolecular N-acyloxyiminium ion carbocyclization. Synthesis of 6-substituted hydroindole 2-carboxylic acids. (2004) (25)
- Total synthesis of the C19-C29 aliphatic segment of (+)-rifamycin S - A formal synthesis of the antibiotic (1982) (25)
- Synthesis of trans-fused perhydrofuropyrans and related α-methylene lactones: bicyclic ring-systems present in the ezomycins, the octosyl acids, and certain antitumor terpenoids☆ (1981) (25)
- Structure-based design of a highly constrained nucleic acid analogue: improved duplex stabilization by restricting sugar pucker and torsion angle γ. (2012) (24)
- The stereocontrolled synthesis of enantiopure α-methano heterocycles and constrained amino acid analogs (1996) (24)
- One Step α-Deoxygenation of Unprotected Aldonolactones using Samarium Diiodide-THF/H2O System - A New Synthesis of 2-Deoxy-D-Ribose (1994) (24)
- 1,3-Asymmetric induction in enolate alkylation reactions of N-protected γ-amino acid derivatives (1997) (24)
- A highly convergent and enantiospecific synthesis of acyclic subunits of ionomycin from a single chiral progenitor (1986) (24)
- Exploring alternative Zn-binding groups in the design of HDAC inhibitors: squaric acid, N-hydroxyurea, and oxazoline analogues of SAHA. (2006) (24)
- A comparative docking study and the design of potentially selective MMP inhibitors (2001) (24)
- Applications of organocatalytic asymmetric synthesis to drug prototypes--dual action and selective inhibitors of n-nitric oxide synthase with activity against the 5-HT1D/1B subreceptors. (2011) (23)
- Reaction of Free Carbonyl Sugar Derivatives with Organometallic Reagents. II. 6-Deoxy-L-idose and a Branched-Chain Sugar1-3 (1962) (23)
- Azacyclic FTY720 Analogues That Limit Nutrient Transporter Expression but Lack S1P Receptor Activity and Negative Chronotropic Effects Offer a Novel and Effective Strategy to Kill Cancer Cells in Vivo. (2016) (23)
- Synthesis of 3 10-helix-inducing constrained analogues of L-proline. (2004) (23)
- Structure-based design and synthesis of novel P2/P3 modified, non-peptidic beta-secretase (BACE-1) inhibitors. (2010) (23)
- Picking the S1, S1' and S2' pockets of matrix metalloproteinases. A niche for potent acyclic sulfonamide inhibitors. (1999) (23)
- Stereoselective synthesis of constrained azacyclic hydroxyethylene isosteres as aspartic protease inhibitors: dipolar cycloaddition and related methodologies toward branched pyrrolidine and pyrrolidinone carboxylic acids. (2005) (23)
- Design and reactivity of organic functional groups—utility of imidazolylsulfonates in the synthesis of monobactams and 3-amino nocardicinic acid (1985) (23)
- Zinc-Mediated Allylation of N-Protected α-Amino Aldehydes in Aqueous Solution. Stereoselective Synthesis of Anti- and Syn-β-Amino Alcohols with Functionalized Allyl Groups (1997) (23)
- Design, synthesis, and thrombin-inhibitory activity of pyridin-2-ones as P2/P3 core motifs. (2008) (22)
- From serine to functionalized enantiopure tetrahydroisoquinolines (2000) (22)
- Total synthesis of malayamycin A and analogues (2006) (22)
- The molecular structure of naphthyridinomycin- a broad spectrum antibiotic (1974) (22)
- Exploring functional and molecular diversity with polymer-bound p-alkoxybenzyl ethers — Scope and applications of preparatively useful organic reactions (1998) (22)
- 1,2-Asymmetric induction in dianionic allylation reactions of amino acid derivatives-synthesis of functionally useful, enantiopure aspartates and constrained scaffolds (1998) (22)
- Total synthesis of the cytotoxic cyclodepsipeptide (-)-doliculide: the "ester" effect in acyclic 1,3-induction of deoxypropionates. (2004) (22)
- Aminoglycoside antibiotics - a method for selective n-acylation based on the temporary protection of amino alcohol functions as copper chelates (1978) (22)
- A one-flask preparation of methyl 6-azido-6-deoxy-α-d-hexopyranosides (1978) (22)
- Synthesis and biological evaluation of novel chiral non-racemic diaminoplatinum analogs based on a tetrahydropyran motif (1993) (22)
- Reaction of lithium dimethylcuprate with conformationally biased β-acyloxy enol esters - regio and stereocontrolled access to functionalized six-carbon chiral synthons (1981) (22)
- Highly Diastereoselective Intramolecular [1,2]-Stevens Rearrangements-Asymmetric Syntheses of Functionalized Isopavines as Morphinomimetics. (2001) (21)
- Lewis-acid catalyzed formation of dihydropyrans (2011) (21)
- Design and synthesis of MMP inhibitors using N-arylsulfonylaziridine hydroxamic acids as constrained scaffolds (2001) (21)
- Highly stereocontrolled sequential asymmetric Michael addition reactions with cinnamate esters - generation of three and four contiguous stereogenic centers on seven-carbon acyclic motifs (1994) (21)
- Concise and stereocontrolled synthesis of the tetracyclic core of daphniglaucin C. (2013) (21)
- Facile Access to 3-Ulosonic Acids via a SmI2-Mediated Reformatsky Reaction on Aldonolactones (1994) (21)
- Lewis acid promoted cyclocondensations of α-ketophosphonoenoates with dienes—from Diels–Alder to hetero Diels–Alder reactions (2002) (21)
- Aminoglycoside antibiotics: synthesis of 5''-amino-5''-deoxyneomycin and 5''-amino-5''-deoxyparomomycin. (1977) (21)
- Conformationally stable and constrained macrocarbocyclic pseudopeptide mimics of beta-hairpin structures. (2002) (21)
- The synthesis of 4,5-methano congeners of α-kainic and α-allo-kainic acids as probes for glutamate receptors (1996) (21)
- Synthesis of Gal determinant epitopes, their glycomimetic variants, and trimeric clusters—relevance to tumor associated antigens and to discordant xenografts (2001) (21)
- Assembly of the c19-c29 aliphatic segment of rifamycin s from d-glucose by the chiron approach (1984) (21)
- Aeruginosine: Chemie und Biologie der Serinprotease-Inhibitoren (2008) (21)
- Substrate-controlled and organocatalytic asymmetric synthesis of carbocyclic amino acid dipeptide mimetics. (2010) (21)
- Toxicity modulation, resistance enzyme evasion, and A-site X-ray structure of broad-spectrum antibacterial neomycin analogs. (2014) (21)
- Probing functional diversity in pactamycin toward antibiotic, antitumor, and antiprotozoal activity. (2013) (21)
- Probing the functional requirements of the l-haba side-chain of amikacin—synthesis, 16S A-site rRNA binding, and antibacterial activity (2003) (21)
- Carbanions in Carbohydrate Chemistry: Novel Methods for Chain Extension and Branching (1972) (20)
- Iminium ion-enamine cascade cyclizations: facile access to structurally diverse azacyclic compounds and natural products. (2014) (20)
- Methodology for the polyene and related antibiotics-versatile and practical access to bifunctional all-trans polyolefinic systems (1987) (20)
- Synthesis of functionally diverse and conformationally constrained polycyclic analogues of proline and prolinol. (2003) (20)
- The stereocontrolled synthesis of 1,2-cis furanosyl nucleosides via a novel anomeric activation (1995) (20)
- The Configuration of Paromose1 (1963) (20)
- Computer-assisted analysis and perception of stereochemical features in organic molecules using the CHIRON program (1990) (20)
- SOLUTION AND SOLID PHASE P-ALKOXYBENZYLATION OF ALCOHOLS UNDER NEUTRAL CONDITIONS (1999) (20)
- Design and synthesis of mimics of S-adenosyl-L-homocysteine as potential inhibitors of erythromycin methyltransferases. (2000) (20)
- Design and synthesis of a novel class of constrained tricyclic pyrrolizidinone carboxylic acids as carbapenem mimics. (2002) (20)
- A facile access to (R)-malic acid (1987) (20)
- A new approach to the synthesis of peptidomimetic renin inhibitors: palladium-catalyzed asymmetric allylation of acyclic alkyl aryl ketones. (2012) (20)
- Design, synthesis, and neuraminidase inhibitory activity of GS-4071 analogues that utilize a novel hydrophobic paradigm. (2002) (19)
- Synthesis and comparative antibacterial activity of verdamicin C2 and C2a. A new oxidation of primary allylic azides in dihydro[2H]pyrans. (2009) (19)
- Iterative synthesis of deoxypropionate units: the inductor effect in acyclic conformation design. (2006) (19)
- Utility of Shift Reagents in Nuclear Magnetic Resonance Studies of Polyfunctional Compounds: N- and O-Acetylated Carbohydrates and Nucleosides (1971) (19)
- Design and synthesis of a prototype model antagonist of tachykinin NK-2 receptor (1994) (19)
- The controlled degradation of avermectin B1a (1986) (19)
- The enterprise of synthesis: from concept to practice. (2012) (19)
- Design and synthesis of macrocyclic indoles targeting blood coagulation cascade Factor XIa. (2010) (19)
- Total stereospecific synthesis of (+) azimic and (+) carpamic acids from D-glucose (1979) (19)
- Synthesis of clustered D-GalNAc (Tn) and D-Galβ(1→3)GalNAc (T) antigenic motifs using a pentaerythritol scaffold (1996) (19)
- Alternative and expedient asymmetric syntheses of L-(+)-noviose. (2008) (19)
- Total synthesis and structural revision of the presumed aeruginosins 205A and B. (2009) (19)
- Tables of the Properties of Deoxy Sugars and Their Simple Derivatives (1971) (19)
- Hybrid aminoglycoside antibiotics via Tsuji palladium-catalyzed allylic deoxygenation. (2011) (19)
- Synthesis of (+)-palitantin (1989) (19)
- Proximity-assisted cycloaddition reactions--facile Lewis acid-mediated synthesis of diversely functionalized bicyclic tetrazoles. (2008) (19)
- Solution- and solid-phase asymmetric synthesis of substituted N-hydroxypyrrolidine dicarboxylic acids (2002) (19)
- Design, Synthesis, and Anti-leukemic Activity of Stereochemically Defined Constrained Analogs of FTY720 (Gilenya). (2013) (18)
- Mass spectrometry in the detemination of structure of certain natural products containing sugars. (2006) (18)
- The total, stereocontrolled synthesis of a chemical precursor to (+)-thienamycin. A formal synthesis of the antibiotic (1982) (18)
- Design and synthesis of diversely substituted azacyclic inhibitors of endothelin converting enzyme. (2006) (18)
- Total Synthesis and Stereochemical Confirmation of 2,5-Diaryl-3,4-dimethyltetrahydrofuran Lignans: (+)-Fragransin A2, (+)-Galbelgin, (+)-Talaumidin, (-)-Saucernetin and (-)-Verrucosin (2007) (18)
- Versatile synthesis of alicyclic and acyclic compounds with alternate and remote C-methyl substitution patterns via asymmetric sequential olefination and ene reactions (1992) (18)
- Total Synthesis and Absolute Stereochemical Assignment of the Insecticidal Metabolites Yaequinolones J1 and J2. (2018) (18)
- The Stereocontrolled Synthesis of (2S,3R)-3-Alkyl-L-aspartic Acids Using a 2-Azetidinone Framework as a Chiral Template (1992) (18)
- THE PURIFICATION AND CHARACTERIZATION OF A NEW ACTIVE IMMUNIZING POLYSACCHARIDE PREPARED FROM STAPHYLOCOCCUS AUREUS. (1964) (18)
- Synthesis of diaminodideoxyalditol analogs of cisplatin as antitumor agents (1993) (18)
- Ring-modified analogues and molecular dynamics studies to probe the requirements for fungicidal activities of malayamycin A and its N-nucleoside variants. (2007) (18)
- Synthesis of a configurational analog of daunorubicin. (1976) (17)
- Some Approaches to the Synthesis of Halodeoxy Sugars (1968) (17)
- Stereocontrolled synthesis of enantiopure diversely functionalized prototypical piperidinone libraries, and constrained analogs of 4-substituted 2-amino adipic acid (2002) (17)
- Design and Synthesis of Glycomimetic Prototypes - A Model Sialyl Lewisx Ligand for E-Selectin (1994) (17)
- Total synthesis of polyoximic acid (2001) (17)
- Synthesis, broad spectrum antibacterial activity, and X-ray co-crystal structure of the decoding bacterial ribosomal A-site with 4′-deoxy-4′-fluoro neomycin analogs (2014) (17)
- Structural Properties and Stereochemically Distinct Folding Preferences of 4,5-cis and trans-Methano-L-Proline Oligomers: The Shortest Crystalline PPII-Type Helical Proline-Derived Tetramer. (2015) (17)
- Functionalized glycomers as growth inhibitors and inducers of apoptosis in human glioblastoma cells. (2003) (16)
- Design of a novel secondary structure scaffolding device: Induction of a reverse turn in tetrapeptides by incorporating a β-amino acid and stereocontrolled free radical α-substitution reactions in peptide motifs (1997) (16)
- The intramolecular inclusion of aromatic esters within β-cyclodextrin as a function of chain length — a detailed NMR study (1995) (16)
- Total synthesis of (+)-ent-cyclizidine: absolute configurational confirmation of antibiotic M146791. (2011) (16)
- The Synthesis of Bicyclic Piperazine-2-carboxylic Acids from L-Proline (2000) (16)
- Tricyclic β-lactams: total synthesis and antibacterial activity of 5α- and 5β-methoxy-tribactams (1995) (16)
- Neighboring-group participation across a furanose ring. Synthesis of 5-acetamido-5-deoxy-D-lyxopyranose from D-arabinose precursors (1967) (16)
- Crystal and molecular structure of a purine arabinonucleoside, 9-β-d-arabinofuranosyladenine hydrochloride (1974) (16)
- Synthesis of tricyclic β-lactams - functionally and topologically novel carbacephems (1994) (16)
- Pyrrolidine as a cogwheel-like scaffold for the deployment of diverse functionality through cycloaddition reactions of metallo-1,3-dipoles in aqueous media. (2000) (16)
- The Reaction of O-Benzylidene Sugars with N-Bromosuccinimide.: VI. A New Synthesis of 2′-Deoxyuridine and some of its Selectively Substituted Derivatives (1972) (16)
- A constrained tricyclic nucleic acid analogue of α-L-LNA: investigating the effects of dual conformational restriction on duplex thermal stability. (2013) (16)
- Computer-assisted perception of similarity using the Chiron program: a powerful tool for the analysis and prediction of biogenetic patterns (1992) (16)
- The N6-(dimethylamino)methylene derivative of 9-beta-D-arabinofuranosyladenine as an antiviral agent. (1973) (16)
- The stereocontrolled synthesis of versatile carbapenem intermediates using the Barton O-acyl 2-thiophyridylhydroxamate fragmentation (1992) (16)
- Anomeric Deoxygenation of 2-Ulosonic Acids Using SmI2: Rapid Access to 2-Deoxy-KDO and 2-Deoxy-NANA (1994) (15)
- Design and Strategy in Organic Synthesis: From the Chiron Approach to Catalysis (2013) (15)
- Synthesis of carbohydrate derivatives containing vinylic thioether groups1 (1971) (15)
- Tricyclic β-lactams: Total synthesis and antibacterial activity of 5α-methoxyethyl and 5α-hydroxyethyl trinems (1997) (15)
- Synthesis and Characterization of 3,6-Diamino-3,6-dideoxy-D-idose1 (1965) (15)
- Toward Overcoming Staphylococcus aureus Aminoglycoside Resistance Mechanisms with a Functionally Designed Neomycin Analogue. (2011) (15)
- Structural identity and stereochemical revision of polyoximic acid (1993) (15)
- Robust polymeric nanoparticles for the delivery of aminoglycoside antibiotics using carboxymethyldextran-b-poly(ethyleneglycols) lightly grafted with n-dodecyl groups (2010) (15)
- Total synthesis of the C-3 – C-17 segment of boromycin (1983) (15)
- Diastereoselective [3,2]-Stevens and Sommelet-Hauser Rearrangements in the Dihydromethanodibenzoazocine Series (2006) (15)
- Vorinostat-like molecules as structural, stereochemical, and pharmacological tools. (2010) (15)
- Synthesis of a phostone glycomimetic of the endothelin converting enzyme inhibitor phosphoramidon. (1999) (15)
- Synthesis of chemically and functionally diverse scaffolds from pentaerythritol (1996) (14)
- Total Synthesis of the Lignan Antibiotic Burseran and a Novel Approach to the Podophyllotoxin Skeleton (1992) (14)
- Design and synthesis of functionalized glycomers as non-peptidic ligands for SH2 binding and as inhibitors of A-431 human epidermoid and HT-29 colon carcinoma cell lines. (2000) (14)
- Design and synthesis of sialyl Lex mimetics based on carbocyclic scaffolds derived from (−) quinic acid (1997) (14)
- Configuration of the anomeric linkages in amicetin. (1964) (14)
- 2-Amino-2-deoxy-D-glucuronic Acid, the Main Constituent of SPA (Staphylococcal Polysaccharide Antigen) (1963) (14)
- Highly stereocontrolled syntheses of 2,3-disubstituted 1,4-butyrolactones using ionic and free radical reactions (1993) (14)
- Crystal structures and molecular conformations of mono-6-azido-6-deoxy α-Cyclodextrin and mono-2-O-allyl-α-cyclodextrin -The formation of polymeric helical inclusion complexes (1995) (14)
- Asymmetric synthesis of diversely substituted N-hydroxypyrrolidines using cycloadditions with chiral nitrone enolate/ylids (2002) (14)
- Asymmetric synthesis of taxol arid taxotère side chains by enolate hydroxylation (1996) (14)
- Assignment of the Position of Amino Groups in Amino Sugars by Mass Spectrometry (1965) (14)
- Carbon-13 n.m.r. studies of the initial binding of Cu(II) toaminoglycoside antibiotics - a useful structural and functional probe. (1978) (14)
- Synthesis of 1′-Homo-N-nucleosides from Hexitols (2003) (14)
- Phosphorylation of a constrained azacyclic FTY720 analog enhances anti-leukemic activity without inducing S1P receptor activation (2016) (14)
- Characterization of Deoxy Sugars by Mass Spectrometry1 (1966) (13)
- Sugar lactams. I. 5-amino-5-deoxy-d-ribonolactam and related products (1964) (13)
- Crystal Structure of a Bioactive Pactamycin Analog Bound to the 30S Ribosomal Subunit☆ (2013) (13)
- Highly chemoselective and stereocontrolled access to 6-alpha-allyl penicillanates (1986) (13)
- Stereoselective synthesis of constrained oxacyclic hydroxyethylene isosteres of aspartic protease inhibitors: aldol and Mukaiyama aldol methodologies for branched tetrahydrofuran 2-carboxylic acids. (2005) (13)
- 6-hydroxy to 6'''-amino tethered ring-to-ring macrocyclic aminoglycosides as probes for APH(3')-IIIa kinase. (2007) (13)
- Facile access to ethyl 2-C-β-D-ribofuranosylacetates (1974) (13)
- Total Synthesis and Absolute Configuration of (-)-Anthoplalone. (1999) (13)
- Stereocontrolled synthesis of a prototype library of enantiopure 2,4-disubstituted 4-aryl-6-piperidinones and piperidines (2002) (13)
- A mass spectral investigation of derivatives of kanamycin A (1973) (13)
- Sugars containing nitrogen in the ring (1965) (13)
- Formation of p-Alkoxybenzylidene Acetals on Solid Support and Generation of Functional Diversity with Carbohydrate Scaffolds (1999) (13)
- Crystal Structures of a Bioactive 6′‐Hydroxy Variant of Sisomicin Bound to the Bacterial and Protozoal Ribosomal Decoding Sites (2013) (13)
- The Reaction of O-Benzylidene Sugars with N-Bromosuccinimide.: VII. Stereochemical and Mechanistic Aspects in the Pyrimidine Nucleoside Series (1972) (13)
- Aminoglycoside antibiotics: chemical transformation of paromamine into 3'-epiparomamine. (1973) (13)
- Methyl 2,3-O-Isopropylidene-β-D-ribo-pentodialdofuranoside: a Useful Intermediate in Chain Extension Reactions (1971) (12)
- Phenolic P2/P3 core motif as thrombin inhibitors--design, synthesis, and X-ray co-crystal structure. (2006) (12)
- Ring contraction and epimerization during a displacement reaction of a hexose sulphonate (1966) (12)
- Sugar lactams. II. 4-Amino-4-deoxy-d-erythronolactam and related products (1964) (12)
- Synthesis of a potent antagonist of E-selectin. (2002) (12)
- Chemistry of the glycosidic linkage. A rapid and efficient synthesis of carbohydrate 1,2-orthoesters (1975) (12)
- General stereocontrolled strategy for the heteroyohimbine alkaloids: the total synthesis of (-)-ajmalicine and (+)-19-epiajmalicine (1991) (12)
- The Practice of Ring Constraint in Peptidomimetics Using Bicyclic and Polycyclic Amino Acids (2009) (12)
- Tetrahydrofuran as a Scaffold for Peptidomimetics. Application to the Design and Synthesis of Conformationally Constrained Metalloproteinase Inhibitors (2000) (12)
- Facile access to chiral 5-hydroxy-2-methylhexanoic acid lactones (pheromones of the carpenter Bee) (1982) (12)
- Probing the binding site of the penicillin side-chain based on the tipper-Strominger hypothesis (1993) (12)
- SYNTHETIC APPROACHES TO POLYHYDROXY INDOLIZIDINES AND RELATED AZABICYCLIC SCAFFOLDS (2006) (12)
- A scalable synthesis of 1-cytosinyl-N-malayamycin A : A potent fungicide (2006) (12)
- Utilization of functionalized polymers in synthesis: immobilization of carbohydrates as acetals, and some chemical transformations (1974) (11)
- Innovations in Synthetic Carbohydrate Chemistry—Practical and Conceptual Approaches to Glycoside Synthesis (1977) (11)
- Mild and efficient preparation of γ-substituted α,β-unsturated γ-butyrolactones from epoxides (1986) (11)
- Stereocontrolled solution and solid phase enolate alkylations and hydroxylations — generation of three and four contiguous stereogenic carbon atoms in acyclic systems (1999) (11)
- The Use of 3‐Phenylselenobutanal as a Crotonaldehyde Equivalent in Synthesis. (1986) (11)
- Aminoglycoside antibiotics: oxidative degradations leading to novel biochemical probes and synthetic intermediates. (1975) (11)
- Design, Synthesis, and Optimization of Balanced Dual NK1/NK3 Receptor Antagonists. (2014) (11)
- Stereoselective synthesis of constrained oxacyclic hydroxyethylene isosteres of aspartyl protease inhibitors. Nitroaldol methodology toward 2,3-substituted tetrahydrofurans (2004) (11)
- Structural hybridization of three aminoglycoside antibiotics yields a potent broad-spectrum bactericide that eludes bacterial resistance enzymes (2016) (11)
- Structure-based organic synthesis of a tricyclic N-malayamycin analogue. (2006) (11)
- Effects of stereochemistry, saturation, and hydrocarbon chain length on the ability of synthetic constrained azacyclic sphingolipids to trigger nutrient transporter down-regulation, vacuolation, and cell death. (2016) (10)
- Strategies toward the Total Synthesis of Calyciphylline B-type Alkaloids: A Computational Perspective Aided by DFT Analysis. (2016) (10)
- Synthesis of cis- and trans-α-l-[4.3.0]bicyclo-DNA monomers for antisense technology: methods for the diastereoselective formation of bicyclic nucleosides. (2013) (10)
- From natural products to achiral drug prototypes: potent thrombin inhibitors based on P2/P3 dihydropyrid-2-one core motifs. (2009) (10)
- Efficient olefination with α-alkyl cyclic phosphonamides (1993) (10)
- Hydrophilic analogs of (R,R)-diaminocyclohexane dichloroplatinum (DACH) and the influence of relative stereochemistry on antitumor activity (1993) (10)
- A remarkably facile and stereochemically controlled fragmentation reaction in the hygrolide group of macrolide antibiotics (1996) (10)
- Chemistry of the glycosidic linkage. Lewis acid catalyzed glycosidations with amide acetals and lactim ethers. (1976) (10)
- Regiospecific and asymmetric introduction of functionalized branching in carbohydrates (1973) (10)
- Synthesis of 19-epi-avermectin A1a from avermectin B1a (1991) (10)
- FT-IR and 1H NMR spectroscopic studies of C2′- endo, C3′-endo sugar ring conformations in 5′-GMP and 3′-GMP nucleotides and their platinum complexes (1986) (10)
- Application of cyclic phosphonamide reagents in the total synthesis of natural products and biologically active molecules (2014) (10)
- Alternative syntheses of (S)-cEt-BNA: a key constrained nucleoside component of bioactive antisense gapmer sequences. (2014) (10)
- Dynamic Phosphoproteomics Uncovers Signaling Pathways Modulated by Anti-oncogenic Sphingolipid Analogs* (2018) (10)
- Exploring the unique reactivities of heterobicyclic tetrazoles—access to functionally diverse and versatile heterocyclic scaffolds (2009) (10)
- Ammonium Molybdate as Spraying Agent for Paper Chromatograms of Reducing Sugars (1958) (10)
- An unprecedented ring expansion in the Macrolide series - synthesis of iso-bafilomycin A1 (1994) (10)
- Man, machine and visual imagery in strategic synthesis planning: computer-perceived precursors for drug candidates. (2005) (10)
- A stereocontrolled rearrangement of spectinomycin - the stereochemical identity of spectinoic acid (1981) (10)
- Drug‐like sphingolipid SH‐BC‐893 opposes ceramide‐induced mitochondrial fission and corrects diet‐induced obesity (2021) (9)
- Synthesis of a Conformationally Constrained Analog of N-Acetylmuramyl Dipeptide (MDP) (1991) (9)
- Structure-based design, synthesis, and A-site rRNA cocrystal complexes of functionally novel aminoglycoside antibiotics: C2" ether analogues of paromomycin. (2007) (9)
- Kinetic diastereomer differentiation in Au(III)- and Bi(III)-catalyzed benzylic arylation: concise and stereocontrolled synthesis of 2-amino-1,1-diarylalkanes. (2014) (9)
- Conception and evolution of stereocontrolled strategies toward functionalized 8-aryloctanoic acids related to the total synthesis of aliskiren. (2014) (9)
- Synthesis and biological evaluation of 1-substituted-7-(1-hydroxyethyl) carbacephems - a class of “hybrid” bicyclic β-lactams (1994) (9)
- Self-assembly of noncyclic bis-D- and L-tripeptides into higher order tubular constructs: design, synthesis, and X-ray crystal superstructure. (2008) (9)
- Synthesis of a Model Tetracyclic Core Structure of Calyciphylline B-Type Alkaloids. (2016) (9)
- The Iterative Synthesis of Acyclic Deoxypropionate Units and Their Implication in Polyketide‐Derived Natural Products (2006) (9)
- Design, synthesis, and duplex-stabilizing properties of conformationally constrained tricyclic analogues of LNA. (2016) (9)
- Solution and Solid-Phase Stereocontrolled Synthesis of 1,2-cis-Glycopyranosides with Minimally Protected Glycopyranosyl Donors Catalyzed by BF3-N,N-Dimethylformamide Complex. (2016) (9)
- Synthesis of Aminocyclodextrin Carboxylic Acids (2008) (9)
- From glyceraldehyde to functionalized enantiopure tetrahydronaphthalenes and indanes (2001) (9)
- One-Step Stereocontrolled Synthesis of α-Anomeric Carboxylic Acid Esters from Unprotected Glycosyl Donors: A Water-Soluble Aspirin Pro-Drug Analogue (2002) (9)
- Sulfonamide-based acyclic and conformationally constrained MMP inhibitors: from computer-assisted design to nanomolar compounds. (2004) (9)
- Studies toward the generation of functionalized quaternary carbon centers relying on Wittig and Wittig-Still allylic ether anionic transpositions. (2013) (9)
- Biomimetic synthesis and structural refinement of the macrocyclic dimer aminoglycoside 66-40C--the remarkably selective self-condensation of a putative aldehyde intermediate in the submerged culture medium producing sisomicin. (2010) (9)
- Aminoglycoside antibiotics: Synthesis of pseudotrisaccharides derived from neamine and paromamine (1978) (9)
- Novel Synthetic Approaches to Monocyclic β‐Lactam Antibiotics (1985) (9)
- AMINOGLYCOSIDE ANTIBIOTICS, CHEMICAL TRANSFORMATION OF PAROMOMYCIN INTO A BIOACTIVE PSEUDOTRISACCHARIDE (1975) (8)
- Chemistry and Biology of the Aeruginosin Family of Serine Protease Inhibitors (2008) (8)
- Probing the ribosomal RNA A-site with functionally diverse analogues of paromomycin—synthesis of ring I mimetics (2007) (8)
- Reductive Fragmentation of Tetrazoles: Mechanistic Insights and Applications toward the Stereocontrolled Synthesis of 2,6-Polysubstituted Morpholines. (2019) (8)
- The crystal and molecular structure of naphthyridinomycin, C21H27N3O6, a broad spectrum antibiotic (1976) (8)
- Application and Scope of Schreiber's Gold(I)‐Catalyzed α‐Pyrone Synthesis to Ring A Aromatic Podolactones (2014) (8)
- Synthesis of N-Hydroxy α-Amino Acids from α-Hydroxy Acids with High Enantiomeric Purity (1995) (8)
- Aminoglycoside antibiotics: Studies directed toward the selective modification of hydroxyl groups: Synthesis of 3′-epiparomamine and 3′-epineamine (1978) (8)
- Synthese stereocontrolee des precurseurs chiraux des 11-oxaprostaglandines (1974) (8)
- Design and synthesis of novel, pseudo C2 symmetric inhibitors of HIV protease (1996) (8)
- Conception and Synthesis of Oxabicyclic Nucleoside Phosphonates as Internucleotidic Phosphate Surrogates in Antisense Oligonucleotide Constructs. (2018) (8)
- Academic-Industrial Collaboration: Toward the Consilience of Two Solitudes. (2016) (7)
- 3-N,N-Dimethylamino-3-deoxy lincomycin: a structure-based hybrid between lincomycin and the desosamine unit of erythromycin. (2005) (7)
- DESIGN AND REACTIVITY OF ORGANIC FUNCTIONAL GROUPS: IMIDAZOLYLSULFONATE (IMIDAZYLATE) - AN EFFICIENT AND VERSATILE LEAVING GROUP (1982) (7)
- Deoxy sugars. (1966) (7)
- Conformation of MurNAc-L-Ala-D-iGln (MDP) and of a constrained analog using 1H NMR data and molecular modeling (1992) (7)
- An Organocatalytic Approachto Enantiopure 2,6-Disubstituted Tetrahydropyranols (2010) (7)
- Total synthesis of isodeoxypodophyllotoxin using the Me3Sn radical initiated carbocyclization (1996) (7)
- Bis-homo avermectin B1a - A semi-synthetic analog with a trienic 18-membered macrocyclic ring (1993) (7)
- Synthetic approaches to β-lactam antibiotics: a stereocontrolled synthesis of trans 3-(S)-amino-4-(S)-ethyl-2-oxo-1-azetidine (1984) (7)
- Synthesis and biological evaluation of sialyl-oligonucleotide conjugates targeting leukocyte B trans-membranal receptor CD22 as delivery agents for nucleic acid drugs. (2016) (7)
- Carbanions in carbohydrate chemistry: a new synthesis of C-glycosyl compounds (1971) (7)
- Design and reactivity of organic functional groups: the highly crystalline 2-alkoxy N,N′-diphenyl-1,3,2-diazaphospholanes and their facile conversion into alkyl halides☆ (1982) (7)
- Design and synthesis of novel N-sulfonyl-2-indoles that behave as 5-HT6 receptor ligands with significant selectivity for D3 over D2 receptors. (2017) (7)
- Exploration of beta-turn scaffolding motifs as components of sialyl Le(X) mimetics and their relevance to P-selectin. (1998) (7)
- Synthesis of conformationally constrained potential inhibitors of mammalian metalloproteinases (1997) (7)
- Novel access to 2′-deoxyuridine, and reactive intermediates to pyrimidine nucleosides (1971) (7)
- Applications of the N-tert-Butylsulfonyl(Bus) Protecting Group in Amino Acid and Peptide Chemistry (2009) (7)
- A Novel Regiospecific Synthesis of 2-Substituted Pyridines (1987) (7)
- AMINOGLYCOSIDE ANTIBIOTICS‐ THE FORMATION AND CHARACTERIZATION OF DIHYDROOXAZINE DERIVATIVES IN THE PAROMOMYCIN SERIES (1978) (6)
- A new synthesis of methylene acetals (1973) (6)
- Free radical-induced C-allylation of α-bromolactones. Synthesis of 2-C-allyl-2-deoxy-d-arabino-and -d-ribono-1,4-lactones (1992) (6)
- Synthesis of Functionalized Octahydroindoles Related to Daphnyphyllum Alkaloids (2014) (6)
- The diaxial-diequatorial rearrangement in the carbohydrate series (1970) (6)
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- Corrigendum to “Lewis acid promoted cyclocondensations of α-ketophosphonoenoates with dienes—from Diels–Alder to hetero Diels–Alder reactions” (2002) (0)
- The Stereocontrolled Formation of Cyclic Vicinal cis‐Diols via a Samarium Diiodide Pinacol Coupling of Dialdehydes. (1991) (0)
- Lewis Acid Promoted Cyclocondensations of α‐Ketophosphonoenoates with Dienes — From Diels—Alder to hetero Diels—Alder Reactions. (2002) (0)
- A Tactically Novel Alternative to Acyclic Stereoselection Based on the Concept of a Replicating Chiron - Access to 1,3-Polyols. (1986) (0)
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- AUSGEWAEHLTE METHODEN DER OX. VON KOHLENHYDRATEN (1971) (0)
- Hydrophilic Analogues of (R,R)-Diaminocyclohexane Dichloroplatinum ( DACH) and the Influence of Relative Stereochemistry on Antitumor Activity. (1994) (0)
- CHEMISTRY OF THE GLYCOSIDIC LINKAGE. β-D-RIBOFURANOSYL DISACCHARIDES VIA GLYCOSIDATION WITH CYCLIC AMIDE ACETALS (1976) (0)
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- One‐ and Two‐Directional Iterative 1,2‐Asymmetric Induction in Acyclic Systems — Easy Access to anti,anti and anti,syn Dipropionate and Diphenylacetate Stereotriads. (1999) (0)
- Enantioselective Synthesis of 3-Substituted Tryptamines as Core Components of Central Nervous System Drugs and Indole Natural Products. (2013) (0)
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- Stereocontrolled Synthesis of All-syn 3,4-Disubstituted L-Prolines: Studies of the Reductive Rearrangement of Unactivated Tertiary Allylic Alcohols. (2014) (0)
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- A Novel Regiospecific Synthesis of 2-Substituted Pyridines. (1987) (0)
- TOTAL STEREOSPECIFIC SYNTHESIS OF (+)-AZIMIC AND (+)-CARPAMIC ACIDS FROM D-GLUCOSE (1980) (0)
- Crystal structure of the bacterial ribosomal decoding site in complex with 4'-deoxy-4'-fluoro neomycin analog (2015) (0)
- Crystal and molecular structure of naphthyridinomycin. A broad spectrum antibiotic (1975) (0)
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- Synthesis and Biological Evaluation of Constrained Phosphonoglutamic Acids as Metabotropic Agents (1998) (0)
- Asymmetric Synthesis of Taxol and Taxotere Side Chains by Enolate Hydroxylation (1996) (0)
- Studies Directed toward the Total Synthesis of Antibiotics:(+)-Spectinomycin (Proceedings of the 5th Anniversary Symposium of Institute of Bioorganic Chemistry) (1979) (0)
- Enantioselective Allylation of α‐Ketoester Oximes with an External Chiral Ligand: Asymmetric Synthesis of Allylglycines and Allylalanine. (1997) (0)
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- Synthesis and Biological Evaluation of 1-Substituted-7-(1-hydroxyethyl) carbacephems - A Class of “Hybrid” Bicyclic β-Lactams. (1995) (0)
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- CARBANIONEN IN DER KOHLENHYDRAT-CHEMIE, EINE NEUE SYNTH. VON C-GLYKOSYL-VERBINDUNGEN (1971) (0)
- NEUE VERFAHREN ZUR ANOMEREN C‐FUNKTIONALISIERUNG, ZUGANG ZU CHEMISCHEN VORLAEUFERN VON C‐NUCLEOSIDEN (1973) (0)
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- Highly Stereoselective Free-Radical C-6-Allylation of Penams-Synthesis of a Novel β-Lactamase Inhibitor. (1989) (0)
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- Yb(OTf)₃-MEDIATED RING OPENING OF FUNCTIONALIZED CYCLOPENTANE EPOXIDES WITH ANILINE : ASPECTS OF REGIOCHEMISTRY AND STEREOCHEMISTRY (Dedicated to Professor Victor Snieckus on the occasion of his 77th birthday) (2014) (0)
- Anomeric Deoxygenation of 2‐Ulosonic Acids Using SmI2: Rapid Access to 2‐Deoxy‐KDO and 2‐Deoxy‐NANA. (1995) (0)
- 33 – 1,2-Orthoester Formation and Glycosidation with Amide Acetals (1980) (0)
- Mild and Efficient Preparation of γ-Substituted α,β-Unsaturated γ-Butyrolactones from Epoxides. (1986) (0)
- The Stereocontrolled Synthesis of (2S,3R)‐3‐Alkyl‐L‐aspartic Acids Using a 2‐Azetidinone Framework as a Chiral Template. (1992) (0)
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- A General Stereocontrolled Strategy for the Heteroyohimbine Alkaloids: The Total Synthesis of (-)-Ajmalicine (Ia) and (+)-19-Epiajmalicine ( Ib). (1991) (0)
- DESIGN AND REACTIVITY OF ORGANIC FUNCTIONAL GROUPS: THE HIGHLY CRYSTALLINE 2-ALKOXY-N,N′-DIPHENYL-1,3,2-DIAZAPHOSPHOLANES AND THEIR FACILE CONVERSION INTO ALKYL HALIDES (1983) (0)
- Total Synthesis of N-Malayamycin A (I) and Related Bicyclic Purine and Pyrimidine Nucleosides. (2005) (0)
- Synthesis of 1-N-Hydroxyhydantoin 5-Phosphates as Potential Fungicides. (2010) (0)
- A Versatile Synthesis of a β‐Turn Peptidomimetic Scaffold: An Approach Towards a Designed Model Antagonist of the Tachykinin NK‐2 Receptor. (1996) (0)
- SYNTHESIS AND ANTITUMOR ACTIVITY OF 4′-DEOXYDAUNORUBICIN AND 4′-DEOXYADRIAMYCIN (1977) (0)
- A Novel Asymmetric Synthesis of α‐ and β‐Amino Aryl Phosphonic Acids. (1994) (0)
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- Intramolecular Free-Radical Ring Closures. Part 2. Structures of Two Bicyclic Lactones (1990) (0)
- DESIGN, SYNTHESIS, AND X-RAY CRYSTAL STRUCTURE OF AN ENZYME BOUND BISUBSTRATE HYBRID INHIBITOR OF ADENYLOSUCCINATE SYNTHETASE (1999) (0)
- A Synthetic Strategy for Tricholomic Acid and Acivicin. (1987) (0)
- Design and Reactivity of Organic Functional Groups. 2-Pyridinesulfonates as Nucleofugal Esters: Remarkably Mild Transformations into Halides and Olefins. (1989) (0)
- Oligosaccharide Synthesis by Remote Activation: O-Protected 3-Methoxy- 2-pyridyloxy (MOP) Glycosyl Donors (1997) (0)
- Yb(OTf)3-Mediated Ring Opening of Functionalized Cyclopentane Epoxides with Aniline: Aspects of Regiochemistry and Stereochemistry. (2014) (0)
- Crystal structure of human beta secretase complexed with NVP-AMK640 (2006) (0)
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- Synthesis of (+)-Avermectin B1a. (1986) (0)
- PREPARATION AND SYNTHETIC UTILITY OF TERT-BUTYLDIPHENYLSILYL ETHERS (1976) (0)
- A Tactically Novel Alternative to Acyclic Stereoselection Based on the Concept of a Replicating Chiron. (1986) (0)
- PREPARATIVE AND EXPLORATORY CARBOHYDRATE CHEMISTRY. CARBANIONS IN CARBOHYDRATE CHEMISTRY, SYNTHESIS OF C-GLYCOSYL MALONATES (1974) (0)
- Stereocontrolled Solution and Solid Phase Enolate Alkylations and Hydroxylations — Generation of Three and Four Contiguous Stereogenic Carbon Atoms in Acyclic Systems. (1999) (0)
- FT-IR and1H NMR Spectroscopic Studies of C2′-endo, C3′-endo Sugar Ring Conformations in 5′-GMP and 3′-GMP Nucleotides and Their Platinum Complexes (I)-(III). (1986) (0)
- Total Synthesis of “Aliskiren” (IV): The First Renin Inhibitor in Clinical Practice for Hypertension. (2010) (0)
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- Nya perhydroisoindoler, deras framstaellning Science innehaollande of pharmaceutical industry preparat (1993) (0)
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- Design And Synthesis Of An Azabicyclic Nucleoside Phosphoramidite For Oligonucleotide Antisense Constructs (2020) (0)
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- “QUANTAMYCIN” - A COMPUTER-SIMULATED NEW-GENERATION INHIBITOR OF BACTERIAL RIBOSOMAL BINDING (1985) (0)
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- PRAEPARATIVE UND EXPLORATIVE KOHLENHYDRAT-CHEMIE, CHEMIE UND SYNTHETISCHE VERWENDBARKEIT VON ALPHA-(DIMETHYLAMINO)-BENZYLIDEN UND -AETHYLIDEN-ACETAL (1972) (0)
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- VERSCHIEDENE ANWENDUNGEN REAKTIVER ZWISCHENSTUFEN DER HYDRIDUEBERTRAGUNG BEI GLUCOSIDEN (1973) (0)
- TETRAHEDRON REPORT NUMBER 426 Design and Synthesis of Conformationally Constrained Amino Acids as Versatile Scaffolds and Peptide Mimetics (1997) (0)
- CCDC 797988: Experimental Crystal Structure Determination (2011) (0)
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- Total Synthesis of (+)-Meroquinene. (1990) (0)
- Asymmetric Conjugate Additions of Chiral Allyl‐ and Crotylphosphonamide Anions to α,β‐Unsaturated Carbonyl Compounds: Highly Stereocontrolled Access to Vicinally Substituted Carbon Centers and Chemically Asymmetrized Chirons. (1994) (0)
- Synthesis of Conformationally Constrained Potential Inhibitors of Mammalian Metalloproteinases. (1998) (0)
- 2-modified penams, their preparation and their use (1985) (0)
- Carbohydrates vs. Non-Carbohydrates in Organic Synthesis (1986) (0)
- Stereocontrolled Synthesis of 1,3‐Substituted 2‐Oxabicyclo[3.1.0]hexanes as Ring‐Constrained Tetrahydrofuranosyl C‐Glycosides (2022) (0)
- Sn2-Type Halogenation and Azidation Reactions with Carbohydrate Triflates (1997) (0)
- DIAXIALE-DIAEQUATORIALE UMLAGERUNG IN DER REIHE DER KOHLENHYDRATE (1971) (0)
- CHEMIE VON 1‐DIMETHYLAMINO‐AETHYLIDEN UND ALPHA‐(DIMETHYLAMINO)‐BENZYLIDENACETALEN, VERWENDUNG ALS SCHUTZMITTEL FUER DIOLE UND FUER SELEKTIVE VERESTERUNGSRK. (1971) (0)
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- PRAEPARATIVE UND EXPLORATIVE KOHLENHYDRAT-CHEMIE, CARBANIONEN IN DER KOHLENHYDRAT-CHEMIE, NEUARTIGE METHODEN ZUR KETTENVERLAENGERUNG UND -VERZWEIGUNG (1972) (0)
- Neue Perhydroisoindolderivate, ihre Herstellung und diese enthaltende pharmazeutische Zusammensetzungen (1992) (0)
- RK. VON O‐BENZYLIDENZUCKERN MIT N‐BROMSUCCINIMID 6. MITT. NEUE SYNTH. VON 2′‐DESOXY‐URIDIN UND SELEKTIV SUBSTITUIERTEN DERIVATEN (1972) (0)
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- An FT-IR and1H NMR Spectral Study of Sugar Ring Conformations in Guanosine and in Several Platinum(II) Complexes (1986) (0)
- SYNTH. VON KOHLENHYDRAT-DERIVATEN MIT EINER VINYL-THIOAETHER-GRUPPE (1971) (0)
- TRITYLPYRIDINIUM‐FLUOROBORAT, EIN WIRKSAMES MITTEL ZUR TRITYLIERUNG (1973) (0)
- UNTERSUCHUNG SUBSTITUIERTER CYCLOHEPTATRIENCARBONSAEUREN DURCH NMR-SPEKTREN (1970) (0)
- Structure of a Tricyclic Lactone - An Important Intermediate for the Total Synthesis of Dihydromevinolin (1989) (0)
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- CHEMIE DER ALPHA-ALKOXY-SULFOXIDE, BLDG. VON METHYLENACETALEN AUS DIMETHYLSULFOXID UND ALKOHOLEN (1973) (0)
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- β‐Substituted D‐leucines and Their Relevance in the Total Synthesis of Natural and Unnatural Aeruginosins (2009) (0)
- Nucleophilic Displacements of Imidazole-1-sulfonate Esters (2010) (0)
- 2-Oxa-5-azabicyclo[2.2.1]heptane as a Platform for Functional Diversity: Synthesis of Backbone-Constrained γ-Amino Acid Analogues. (2022) (0)
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- Heteroatom-Assisted Substitution of Acyclic Secondary Tosylates with Lithium Dialkylcuprates: An Expedient Route to Stereochemically Defined Deoxypropionate and Related Biosynthetic Subunits. (1990) (0)
- Back Cover: Crystal Structures of a Bioactive 6′-Hydroxy Variant of Sisomicin Bound to the Bacterial and Protozoal Ribosomal Decoding Sites (ChemMedChem 5/2013) (2013) (0)
- ChemInform Abstract: Design and Synthesis of a Novel Class of Constrained Tricyclic Pyrrolizidinone Carboxylic Acids as Carbapenem Mimics. (2002) (0)
- Synthesis of Surrogate Structures Related to the Herbicidal Agent Hydantocidin (XII). (1995) (0)
- Synthesis of 1-Cytosinyl-N-malayamycin A (2006) (0)
- Total Synthesis and Absolute Configuration of (‐)‐Anthoplalone. (2010) (0)
- A Practical Synthesis of 2-Deoxyaldonolactones via a SmI2-Mediated . alpha.-Deoxygenation Reaction. (1992) (0)
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- Application and Scope of Schreiber′s Gold(I)‐Catalyzed α‐Pyrone Synthesis to Ring A Aromatic Podolactones. (2015) (0)
- The structure of 6‐O‐acetyl‐2,3,4‐trideoxy‐4‐C‐ethenyl‐3‐C‐(methoxycarbonylmethyl)‐α‐d‐lyxopyranose, C13H20O6 (1984) (0)
- Synthesis of Tricyclic β-Lactams - Functionally and Topologically Novel Carbacephems. (1995) (0)
- OXIDATION OF ALCOHOLS WITH N-HALOSUCCINIMIDES - NEW AND EFFICIENT VARIANTS (1981) (0)
- Crystal structure of the bacterial ribosomal decoding site in complex with 4'-deoxy-4'-fluoro neamine analog (axial 4'-F) (2016) (0)
- 2‐Pyridinesulfonyl Chloride (2001) (0)
- Catalytic Lewis and Brønsted acid syn-diastereoselective benzylic substitutions of α-hydroxy-β-nitro- and α-hydroxy-β-azido-alkyl arenes (2020) (0)
- The Enterprise of Synthesis: From Concept to Practice (2012) (0)
- Catalytic properties of 4,5-bridged proline methano- and ethanologues in the Hajos–Parrish intramolecular aldol reaction (2022) (0)
- Titelbild: Aeruginosine: Chemie und Biologie der Serinprotease‐Inhibitoren (Angew. Chem. 7/2008) (2008) (0)
- Structure of tert.-Butyl 4-Aminomethyl-3-carboxymethyl-2,3,4-trideoxy- 5-hydroxymethyl-α-D-lyxopyranoside-δ-lactam (1991) (0)
- Crystal structure of the protozoal cytoplasmic ribosomal decoding site in complex with 6'-fluoro sisomicin (2018) (0)
- The Stereocontrolled Synthesis of Enantiopure α‐Methano Heterocycles and Constrained Amino Acid Analogues. (1997) (0)
- Methodology for the Polyene and Related Antibiotics. Versatile and Practical Access to Bifunctional all-trans Polyolefinic Systems (I) and (II). (1987) (0)
- Crystal structure of the bacterial ribosomal decoding site in complex with 6'-fluoro sisomicin (2013) (0)
- The Total Synthesis of (+)-Ionomycin. (1990) (0)
- Asymmetric Synthesis of L-Azetidine-2-carboxylic Acid and 3-Substituted Congeners—Conformationally Constrained Analogues of Phenylalanine, Naphthylalanine, and Leucine. (2010) (0)
- Expedient Assembly of Carbocyclic, Heterocyclic, and Polycyclic Compounds by Me3Sn Radical Mediated Carbocyclizations of Dienes and Trienes: A Novel Oxidative Cleavage of the C-Sn Bond. (1992) (0)
- Crystal structure of the bacterial ribosomal decoding site in complex with 4'-deoxy-4'-fluoro neamine analog (equatorial 4'-F) (2016) (0)
- Design, Synthesis, and Neuraminidase Inhibitory Activity of GS‐4071 Analogues that Utilize a Novel Hydrophobic Paradigm. (2003) (0)
- Structure of triphenyltin adduct C26H28O2Sn resulting from a free-radical reaction (1990) (0)
- Stereocontrolled Functionalization in Acyclic Systems by Exploiting Internal 1,2-Asymmetric Induction - Generation of Polypropionate and Related Motifs. (1997) (0)
- Bifunctional Cooperative Catalysis Toward Tertiary β-Ketols: A Theoretical Mechanistic Study (2015) (0)
- Total Synthesis and Stereochemical Confirmation of Manassantin A (Ia), B (Ib), and B1 (Ic). (2007) (0)
- Strucural properties of 4,5-Methanoprolines and Their oligomers: An Unprecedented Crystalline PPII-Type Helical Tetramer (2015) (0)
- Structural Identity and Stereochemical Revision of Polyoximic Acid. (1993) (0)
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- SYNTHESIS OF A CHIRAL 1,7-DIOXASPIRO(5,5)UNDECENE. A MODEL FOR THE SPIROACETAL SUBUNIT OF AVERMECTIN B1A (1984) (0)
- DIE N(6)-DIMETHYLAMINOMETHYLEN-DERIVATE VON 9-BETA-D-ARABINOFURANOSYLADENIN ALS VIRUSMITTEL (1973) (0)
- Total Synthesis and Structural Confirmation of Malayamycn A: A Novel Bicyclic C‐Nucleoside from Streptomyces malaysiensis. (2004) (0)
- Systematic Investigation of Tether Length and Phosphorus Configuration in Backbone Constrained Macrocyclic Nucleic Acids to Modulate Binding Kinetics for RNA. (2023) (0)
- Iminium Ion—Enamine Cascade Cyclizations: Facile Access to Structurally Diverse Azacyclic Compounds and Natural Products. (2014) (0)
- Hybrids, Congeners, Mimics, and Constrained Variants Spanning 30 Years of Natural Products Chemistry: A Personal Retrospective (2014) (0)
- High caloric product for I.V. administration (1986) (0)
- Total Synthesis of 11‐Oxaprostaglandin F2α and F2β. (1986) (0)
- PREPARATIVE AND EXPLORATORY CARBOHYDRATE CHEMISTRY, ELIMINATION, OXIDATION AND TRANSPOSITION REACTIONS IN CONFORMATIONALLY BIASED CARBOHYDRATES, METHYL 4,6-O-BENZYLIDEN-ALPHA-D-ALTROPYRANOSIDES CONTAINING THE PHENYLTHIO GROUP (1974) (0)
- AMINOGLYCOSIDE ANTIBIOTICS, SYNTHESIS OF 6‐O‐(BETAD‐RIBOFURANOSYL)PAROMAMINE (1975) (0)
- Highly Diastereoselective Intramolecular [1,2]-Stevens Rearrangements-Asymmetric Syntheses of Functionalized Isopavines as Morphinomimetics We thank the NSERC of Canada for financial support through the Medicinal Chemistry Chair program. We thank Dr. Michel Simard for the X-ray crystal structure det (2001) (0)
- Stereocontrolled Synthesis of Enantiopure Diversely Functionalized Prototypical Piperidinone Libraries, and Constrained Analogues of 4-Substituted 2-Amino Adipic Acid. (2002) (0)
- Antibacterial analogs of 4,5-substituted aminoglycoside having multiple substituents (2006) (0)
- Stereocontrolled Synthesis of a Prototype Library of Enantiopure 2,4-Disubstituted 4-Aryl-6-piperidinones and Piperidines. (2002) (0)
- Bis‐Homo Avermectin B1a (I). A Semi‐Synthetic Analog with a Trienic 18‐ Membered Macrocyclic Ring. (1993) (0)
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- Intramolecular Free-Radical Ring Closures. Part 1. Structure of a Chiral Bicyclic Lactone (1990) (0)
- Applications of the N-tert-Butylsulfonyl (Bus) Protecting Group in Amino Acid and Peptide Chemistry. (2010) (0)
- PREPARATIVE AND EXPLORATORY CARBOHYDRATE CHEMISTRY. CHEMISTRY OF THE GLYCOSIDIC LINKAGE. LEWIS ACID-CATALYZED GLYCOSIDATIONS WITH AMIDE ACETALS AND LACTIM ETHERS (1976) (0)
- Structure of a synthetic hexahydrobenzofuran subunit. C16H22O7, related to the avermectins (1988) (0)
- 1,2-Asymmetric Induction in Dianionic Allylation Reactions of Amino Acid Derivatives — Synthesis of Functionally Useful, Enantiopure Aspartates and Constrained Scaffolds. (1998) (0)
- The Asymmetric Synthesis of α-Chloro α-Alkyl and α- Methyl α-Alkyl Phosphonic Acids of High Enantiomeric Purity. (2010) (0)
- Stereocontrolled Sequential Funtionalization in Acyclic Systems by Exploiting Internal 1,2‐Asymmetric Induction ‐ Generation of Symmetry‐ Related Polyamino Alcohol Motifs. (1997) (0)
- Crystal structure of the protozoal cytoplasmic ribosomal decoding site in complex with 6'-hydroxysisomicin (P212121 form) (2013) (0)
- Versatile Synthesis of Alicyclic and Acyclic Compounds with Alternate and Remote C-Methyl Substitution Patterns via Asymmetric Sequential Olefination and Ene Reactions. (1993) (0)
- Total Synthesis of (+)‐Polyoximic Acid. cis‐3‐Ethylidene‐L‐azetidine‐2‐ carboxylic Acid. (1993) (0)
- Conformation of MurNAc‐L‐Ala‐D‐iGln (MDP) and of a Constrained Analogue Using 1H NMR DATA and Molecular Modeling. (1993) (0)
- Structure‐Based Synthesis — From Natural Products to Drug Prototypes (2009) (0)
- CARBANIONEN IN DER KOHLENHYDRAT-CHEMIE, EINE NEUE METHODE ZUR KETTENVERLAENGERUNG (1971) (0)
- Aminoglycoside antibiotics: Synthetis of … etc (1975) (0)
- Design, Synthesis, and Antileukemic Activity of Stereochemically De fi ned Constrained Analogues of FTY720 (Gilenya) (2013) (0)
- Design and Synthesis of Mimics of S‐Adenosyl‐L‐homocysteine as Potential Inhibitors of Erythromycin Methyltransferases. (2000) (0)
- Perhydroisoindolderivate, their production and containing the same drug (1992) (0)
- 2,3-METHYL-2,3-O-ISOPROPYLIDEN-BETA-D-RIBO-PENTADIALDOFURANOSID, EINE NUETZLICHE ZWISCHENSTUFE BEI KETTENVERLAENGERUNGS-RK. (1971) (0)
- Synthesis of (4S)‐Hydroxymethyl‐(2R)‐(2‐propyl)‐butyrolactone: A Quest for a Practical Route to an Important Hydroxyethylene Isostere Chiron. (1997) (0)
- A Novel Synthetic Route to the Hexahydrobenzofuran Subunit of the Avermectins and Milbemycins. (1987) (0)
- Cover Picture: Structure‐Based Organic Synthesis of Drug Prototypes: A Personal Odyssey (ChemMedChem 12/2006) (2006) (0)
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