Stephen J. Benkovic
#20,981
Most Influential Person Now
American chemist
Stephen J. Benkovic's AcademicInfluence.com Rankings
Stephen J. Benkovicchemistry Degrees
Chemistry
#570
World Rank
#1002
Historical Rank
#264
USA Rank
Organic Chemistry
#102
World Rank
#138
Historical Rank
#41
USA Rank
Download Badge
Chemistry
Stephen J. Benkovic's Degrees
- PhD Chemistry Cornell University
- Bachelors Chemistry Lebanon Valley College
Why Is Stephen J. Benkovic Influential?
(Suggest an Edit or Addition)According to Wikipedia, Stephen James Benkovic is an American chemist known for his contributions to the field of enzymology. He holds the Evan Pugh University Professorship and Eberly Chair in Chemistry at The Pennsylvania State University. He has developed boron compounds that are active pharmacophores against a variety of diseases. Benkovic has concentrated on the assembly and kinetic attributes of the enzymatic machinery that performs DNA replication, DNA repair, and purine biosynthesis.
Stephen J. Benkovic's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Assembly of combinatorial antibody libraries on phage surfaces: the gene III site. (1991) (1128)
- A Perspective on Enzyme Catalysis (2003) (976)
- Colloidal Au-Enhanced Surface Plasmon Resonance for Ultrasensitive Detection of DNA Hybridization (2000) (812)
- Generation of a large combinatorial library of the immunoglobulin repertoire in phage lambda. (1989) (761)
- On-chip manipulation of single microparticles, cells, and organisms using surface acoustic waves (2012) (724)
- Allosteric regulation and catalysis emerge via a common route. (2008) (592)
- Relating protein motion to catalysis. (2006) (538)
- At the crossroads of chemistry and immunology: catalytic antibodies. (1991) (523)
- An Antifungal Agent Inhibits an Aminoacyl-tRNA Synthetase by Trapping tRNA in the Editing Site (2007) (517)
- Reversible Compartmentalization of de Novo Purine Biosynthetic Complexes in Living Cells (2008) (443)
- Construction and evaluation of the kinetic scheme associated with dihydrofolate reductase from Escherichia coli. (1987) (415)
- A Dynamic Knockout Reveals That Conformational Fluctuations Influence the Chemical Step of Enzyme Catalysis (2011) (414)
- Network of coupled promoting motions in enzyme catalysis (2002) (391)
- Linkage of recognition and replication functions by assembling combinatorial antibody Fab libraries along phage surfaces. (1991) (384)
- Production of cyclic peptides and proteins in vivo. (1999) (358)
- Surface Sites for Engineering Allosteric Control in Proteins (2008) (325)
- Mechanism of DNA strand transfer reactions catalyzed by HIV-1 reverse transcriptase. (1992) (316)
- DNA polymerase fidelity: kinetics, structure, and checkpoints. (2004) (314)
- Replisome-mediated DNA replication. (2001) (309)
- Peptide synthesis catalyzed by an antibody containing a binding site for variable amino acids. (1994) (308)
- Kinetic mechanism of DNA polymerase I (Klenow). (1987) (305)
- Controlling cell–cell interactions using surface acoustic waves (2014) (288)
- Interaction of dihydrofolate reductase with methotrexate: Ensemble and single-molecule kinetics (2002) (283)
- Folates and pterins (1984) (273)
- A New View into the Regulation of Purine Metabolism: The Purinosome. (2017) (273)
- Replication clamps and clamp loaders. (2013) (250)
- Metallo-β-lactamase: structure and mechanism (1999) (244)
- A combinatorial approach to hybrid enzymes independent of DNA homology (1999) (244)
- Design and Evolution of New Catalytic Activity with an Existing Protein Scaffold (2006) (240)
- Kinetic mechanism whereby DNA polymerase I (Klenow) replicates DNA with high fidelity. (1988) (238)
- Corrigendum: RecG and UvsW catalyse robust DNA rewinding critical for stalled DNA replication fork rescue (2014) (238)
- Free-energy landscape of enzyme catalysis. (2008) (233)
- Backbone dynamics in dihydrofolate reductase complexes: role of loop flexibility in the catalytic mechanism. (2001) (229)
- Flexibility, diversity, and cooperativity: pillars of enzyme catalysis. (2011) (215)
- Kinetic mechanism of DNA polymerase I (Klenow fragment): identification of a second conformational change and evaluation of the internal equilibrium constant. (1991) (203)
- Kinetic characterization of the polymerase and exonuclease activities of the gene 43 protein of bacteriophage T4. (1992) (203)
- Chemical basis for enzyme catalysis. (2000) (202)
- Induction of an antibody that catalyzes the hydrolysis of an amide bond. (1988) (189)
- Boron-containing inhibitors of synthetases. (2011) (184)
- Cloning of the immunological repertoire in Escherichia coli for generation of monoclonal catalytic antibodies: construction of a heavy chain variable region-specific cDNA library. (1989) (178)
- Human immunodeficiency virus type 1 reverse transcriptase: spatial and temporal relationship between the polymerase and RNase H activities. (1992) (177)
- Recombinant HIV-1 nucleocapsid protein accelerates HIV-1 reverse transcriptase catalyzed DNA strand transfer reactions and modulates RNase H activity. (1994) (170)
- Creating multiple-crossover DNA libraries independent of sequence identity (2001) (167)
- Evidence for a functional role of the dynamics of glycine-121 of Escherichia coli dihydrofolate reductase obtained from kinetic analysis of a site-directed mutant. (1997) (162)
- Coupled motions in enzyme catalysis. (2010) (162)
- Coordinated effects of distal mutations on environmentally coupled tunneling in dihydrofolate reductase (2006) (161)
- Tunneling and coupled motion in the Escherichia coli dihydrofolate reductase catalysis. (2004) (161)
- On the mechanism of the metallo-beta-lactamase from Bacteroides fragilis. (1999) (158)
- Catecholate LMCT bands as probes for the active sites of nonheme iron oxygenases (1988) (152)
- A DNA fragment with an alpha-phosphorothioate nucleotide at one end is asymmetrically blocked from digestion by exonuclease III and can be replicated in vivo. (1981) (151)
- Coupling interactions of distal residues enhance dihydrofolate reductase catalysis: mutational effects on hydride transfer rates. (2002) (148)
- Side chains involved in catalysis of the polymerase reaction of DNA polymerase I from Escherichia coli. (1992) (147)
- Spatial colocalization and functional link of purinosomes with mitochondria (2016) (138)
- Elementary steps in the DNA polymerase I reaction pathway. (1983) (138)
- Real-time observation of bacteriophage T4 gp41 helicase reveals an unwinding mechanism (2007) (136)
- Combinatorial protein engineering by incremental truncation. (1999) (135)
- Split-intein mediated circular ligation used in the synthesis of cyclic peptide libraries in E. coli (2007) (135)
- Regulation of polymerase exchange between Polη and Polδ by monoubiquitination of PCNA and the movement of DNA polymerase holoenzyme (2008) (133)
- Impact of distal mutations on the network of coupled motions correlated to hydride transfer in dihydrofolate reductase. (2005) (131)
- Metabolomics and mass spectrometry imaging reveal channeled de novo purine synthesis in cells (2020) (130)
- Mechanism of action of fructose 1,6-bisphosphatase. (1982) (125)
- Inhibition of HIV budding by a genetically selected cyclic peptide targeting the Gag-TSG101 interaction. (2008) (123)
- The nucleotide analog 2-aminopurine as a spectroscopic probe of nucleotide incorporation by the Klenow fragment of Escherichia coli polymerase I and bacteriophage T4 DNA polymerase. (1995) (122)
- A perspective on biological catalysis (1996) (121)
- Dynamics of a flexible loop in dihydrofolate reductase from Escherichia coli and its implication for catalysis. (1994) (119)
- Insights into enzyme function from studies on mutants of dihydrofolate reductase. (1988) (119)
- A mutant of DNA polymerase I (Klenow fragment) with reduced fidelity. (1991) (119)
- Dynamics of the dihydrofolate reductase-folate complex: catalytic sites and regions known to undergo conformational change exhibit diverse dynamical features. (1995) (118)
- Solvation, Reorganization Energy, and Biological Catalysis* (1998) (117)
- [13] Purification and characterization of human immunodeficiency virus type 1 reverse transcriptase (1995) (117)
- The dynamic processivity of the T4 DNA polymerase during replication. (2004) (117)
- Perspectives on Electrostatics and Conformational Motions in Enzyme Catalysis (2015) (115)
- Conformational changes in the active site loops of dihydrofolate reductase during the catalytic cycle. (2004) (114)
- A fluorescence-based assay for monitoring helicase activity. (1994) (109)
- Evolution of cyclic peptide protease inhibitors (2011) (109)
- Rate-limiting steps in the DNA polymerase I reaction pathway. (1985) (109)
- Finding Cinderella's slipper—proteins that fit (1999) (108)
- Catalytic antibodies with lipase activity and R or S substrate selectivity. (1989) (108)
- Rapid generation of incremental truncation libraries for protein engineering using alpha-phosphothioate nucleotides. (2001) (108)
- Substrate-driven chemotactic assembly in an enzyme cascade. (2018) (107)
- A systematic method for identifying small-molecule modulators of protein-protein interactions. (2004) (102)
- A stereospecific cyclization catalyzed by an antibody. (1987) (102)
- Stereochemical course of the reaction catalyzed by 5'-nucleotide phosphodiesterase from snake venom. (1979) (102)
- Antibody remodeling: a general solution to the design of a metal-coordination site in an antibody binding pocket. (1990) (100)
- Creating a dynamic picture of the sliding clamp during T4 DNA polymerase holoenzyme assembly by using fluorescence resonance energy transfer (2001) (100)
- A mass spectrometric solution to the address problem of combinatorial libraries. (1994) (98)
- Identification of borinic esters as inhibitors of bacterial cell growth and bacterial methyltransferases, CcrM and MenH. (2005) (96)
- Effects of the donor-acceptor distance and dynamics on hydride tunneling in the dihydrofolate reductase catalyzed reaction. (2012) (96)
- Structural requirements for the biosynthesis of backbone cyclic peptide libraries. (2001) (94)
- Coupling DNA unwinding activity with primer synthesis in the bacteriophage T4 primosome (2009) (92)
- Ring Structure and Aromatic Substituent Effects on the pK a of the Benzoxaborole Pharmacophore. (2012) (92)
- NMR characterization of the metallo-beta-lactamase from Bacteroides fragilis and its interaction with a tight-binding inhibitor: role of an active-site loop. (1999) (92)
- On the mechanism of action of folate- and biopterin-requiring enzymes. (1980) (91)
- The control mechanism for lagging strand polymerase recycling during bacteriophage T4 DNA replication. (2006) (90)
- Construction and characterization of a bacteriophage T4 DNA polymerase deficient in 3'-->5' exonuclease activity. (1993) (90)
- Conformation coupled enzyme catalysis: single-molecule and transient kinetics investigation of dihydrofolate reductase. (2005) (90)
- Direct observation of an enzyme-bound intermediate in the catalytic cycle of the metallo-β-lactamase from Bacteroides fragilis [15] (1998) (88)
- DNA polymerase as a molecular motor and pump. (2014) (88)
- Transition-state stabilization as a measure of the efficiency of antibody catalysis (1995) (88)
- Purification, Characterization, and Kinetic Studies of a SolubleBacteroides fragilis Metallo-β-lactamase That Provides Multiple Antibiotic Resistance* (1998) (87)
- Characterization of the metal-binding sites of the beta-lactamase from Bacteroides fragilis. (1996) (87)
- Stretching exercises--flexibility in dihydrofolate reductase catalysis. (1998) (84)
- Microtubule-assisted mechanism for functional metabolic macromolecular complex formation (2010) (84)
- DNA substrate structural requirements for the exonuclease and polymerase activities of procaryotic and phage DNA polymerases. (1989) (83)
- Kinetic mechanism of DNA polymerase I (1987) (83)
- Mutations in HIV reverse transcriptase which alter RNase H activity and decrease strand transfer efficiency are suppressed by HIV nucleocapsid protein. (1997) (83)
- Functional significance of evolving protein sequence in dihydrofolate reductase from bacteria to humans (2013) (83)
- Genetically selected cyclic-peptide inhibitors of AICAR transformylase homodimerization. (2005) (82)
- Functional role of a mobile loop of Escherichia coli dihydrofolate reductase in transition-state stabilization. (1992) (82)
- Tunable, pulsatile chemical gradient generation via acoustically driven oscillating bubbles. (2013) (81)
- The Compensation in ΔH[UNK] and ΔS[UNK] Accompanying the Conversion of Lower Order Nucleophilic Displacement Reactions to Higher Order Catalytic Processes. The Temperature Dependence of the Hydrazinolysis and Imidazole-Catalyzed Hydrolysis of Substituted Phenyl Acetates (1964) (80)
- Regulation of Rad6/Rad18 Activity During DNA Damage Tolerance. (2015) (80)
- Quantitative Analysis of Purine Nucleotides Indicates That Purinosomes Increase de Novo Purine Biosynthesis*♦ (2015) (80)
- Glu-111 is required for activation of the DNA cleavage center of EcoRI endonuclease. (1989) (79)
- Mechanism of DNA replication fidelity for three mutants of DNA polymerase I: Klenow fragment KF(exo+), KF(polA5), and KF(exo-). (1991) (79)
- Minimal kinetic mechanism for misincorporation by DNA polymerase I (Klenow fragment). (1992) (79)
- The unique chemistry of benzoxaboroles: current and emerging applications in biotechnology and therapeutic treatments. (2014) (78)
- Hybrid enzymes: manipulating enzyme design. (1998) (78)
- Interaction of DNA with the Klenow fragment of DNA polymerase I studied by time-resolved fluorescence spectroscopy. (1991) (78)
- A distal mutation perturbs dynamic amino acid networks in dihydrofolate reductase. (2013) (78)
- Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis (2001) (78)
- Electron spin-echo studies of the copper binding site in phenylalanine hydroxylase from Chromobacterium violaceum (1988) (77)
- GPCRs regulate the assembly of a multienzyme complex for purine biosynthesis (2011) (77)
- Direct Observation of Stalled Fork Restart via Fork Regression in the T4 Replication System (2012) (76)
- Probing the Electrostatics of Active Site Microenvironments along the Catalytic Cycle for Escherichia coli Dihydrofolate Reductase (2014) (75)
- Characterization of the enzyme complex involving the folate-requiring enzymes of de novo purine biosynthesis. (1980) (75)
- Bait and switch strategy for obtaining catalytic antibodies with acyl-transfer capabilities (1990) (74)
- Enzyme Motions Inside and Out (2006) (73)
- Effects of a distal mutation on active site chemistry. (2006) (73)
- Predicting crossover generation in DNA shuffling (2001) (73)
- Studies on Sulfate Esters. I. Nucleophilic Reactions of Amines with p-Nitrophenyl Sulfate (1966) (72)
- The purinosome, a multi-protein complex involved in the de novo biosynthesis of purines in humans. (2013) (72)
- Phenylalanine hydroxylase. Correlation of the iron content with activity and the preparation and reconstitution of the apoenzyme. (1982) (72)
- Chemistry and biochemistry of folates (1984) (71)
- FamClash: A method for ranking the activity of engineered enzymes (2004) (71)
- Phenylalanine Hydroxylase Stimulator Protein Is a 4α-Carbinolamine Dehydratase (1983) (70)
- Catalytic antibody model and mutagenesis implicate arginine in transition-state stabilization. (1994) (70)
- RecG and UvsW catalyse robust DNA rewinding critical for stalled DNA replication fork rescue (2013) (70)
- Elucidation of the mechanism of the reaction between phenylboronic acid and a model diol, Alizarin Red S. (2012) (69)
- Reductive activation of phenylalanine hydroxylase and its effect on the redox state of the non-heme iron. (1984) (69)
- Sliding clamp of the bacteriophage T4 polymerase has open and closed subunit interfaces in solution. (1999) (68)
- Purification of a complex catalyzing folate cofactor synthesis and transformylation in de novo purine biosynthesis. (1980) (68)
- A cell cycle-regulated adenine DNA methyltransferase from Caulobacter crescentus processively methylates GANTC sites on hemimethylated DNA. (1998) (67)
- The role of enzyme dynamics and tunnelling in catalysing hydride transfer: studies of distal mutants of dihydrofolate reductase (2006) (67)
- The enzymic nature of antibody catalysis: development of multistep kinetic processing. (1990) (67)
- Characterization of bacteriophage T4-coordinated leading- and lagging-strand synthesis on a minicircle substrate. (2000) (67)
- Divalent cation modulation of the ribonuclease functions of human immunodeficiency virus reverse transcriptase. (1995) (67)
- Probing cell-cell communication with microfluidic devices. (2013) (67)
- Peptide bond formation via catalytic antibodies: Synthesis of a novel phosphonate diester hapten (1994) (66)
- Discovery of antibacterial cyclic peptides that inhibit the ClpXP protease (2007) (66)
- Formyltetrahydrofolate hydrolase, a regulatory enzyme that functions to balance pools of tetrahydrofolate and one-carbon tetrahydrofolate adducts in Escherichia coli (1995) (66)
- Incremental truncation as a strategy in the engineering of novel biocatalysts. (1999) (66)
- Mechanism of oxygen activation by pteridine-dependent monooxygenases (1988) (66)
- 6 Chemical Basis of Biological Phosphoryl Transfer (1973) (65)
- Identification of a novel boron-containing antibacterial agent (AN0128) with anti-inflammatory activity, for the potential treatment of cutaneous diseases. (2006) (65)
- Evaluation of the importance of hydrophobic interactions in drug binding to dihydrofolate reductase. (1988) (65)
- Collaborative coupling between polymerase and helicase for leading-strand synthesis (2012) (65)
- The structure of a ring-opened proliferating cell nuclear antigen-replication factor C complex revealed by fluorescence energy transfer. (2006) (65)
- An unexpectedly efficient catalytic antibody operating by ping-pong and induced fit mechanisms. (1991) (65)
- Structure-reactivity correlation for the hydrolysis of phosphoramidate monoanions (1971) (65)
- Reaction Mechanisms Displayed by Catalytic Antibodies (1993) (64)
- Protein-DNA cross-linking demonstrates stepwise ATP-dependent assembly of T4 DNA polymerase and its accessory proteins on the primer-template (1991) (64)
- Mechanism of strand displacement synthesis by DNA replicative polymerases (2012) (63)
- Mapping protein - Protein interactions in the bacteriophage T4 DNA polymerase holoenzyme using a novel trifunctional photo-cross-linking and affinity reagent [11] (2000) (63)
- Accessory proteins function as matchmakers in the assembly of the T4 DNA polymerase holoenzyme (1995) (63)
- Purinosome formation as a function of the cell cycle (2015) (62)
- Catalysis of a stereospecific bimolecular amide synthesis by an antibody. (1988) (62)
- Evolution of protein function by domain swapping. (2000) (62)
- Catalytic reactions of phosphoglucose isomerase with cyclic forms of glucose 6-phosphate and fructose 6-phosphate. (1973) (62)
- Hsp70/Hsp90 chaperone machinery is involved in the assembly of the purinosome (2013) (62)
- Familial mutations and zinc stoichiometry determine the rate-limiting step of nitrocefin hydrolysis by metallo-beta-lactamase from Bacteroides fragilis. (2001) (62)
- Dynamic Regulation of a Metabolic Multi-enzyme Complex by Protein Kinase CK2* (2010) (61)
- Enhanced crossover SCRATCHY: construction and high-throughput screening of a combinatorial library containing multiple non-homologous crossovers. (2003) (61)
- Towards structure-based drug design: crystal structure of a multisubstrate adduct complex of glycinamide ribonucleotide transformylase at 1.96 A resolution. (1995) (61)
- IPRO: an iterative computational protein library redesign and optimization procedure. (2006) (61)
- Mechanism of oxygen activation by tyrosine hydroxylase. (1987) (60)
- Single-molecule and transient kinetics investigation of the interaction of dihydrofolate reductase with NADPH and dihydrofolate. (2004) (60)
- Crystal structure of glycinamide ribonucleotide transformylase from Escherichia coli at 3.0 A resolution. A target enzyme for chemotherapy. (1992) (59)
- Evaluation of mass spectrometric methods applicable to the direct analysis of non-peptide bead-bound combinatorial libraries. (1996) (59)
- Effect of single amino acid replacements on the folding and stability of dihydrofolate reductase from Escherichia coli. (1987) (58)
- A Comparison of the Bimolecular and Intramolecular Nucleophilic Catalysis of the Hydrolysis of Substituted Phenyl Acylates by the Dimethylamino Group (1963) (58)
- Probing the functional role of phenylalanine-31 of Escherichia coli dihydrofolate reductase by site-directed mutagenesis. (1987) (58)
- Biochemical Characterization of Bacteriophage T4 Mre11-Rad50 Complex* (2010) (57)
- On the purification and mechanism of action of 5-aminoimidazole-4-carboxamide-ribonucleotide transformylase from chicken liver. (1981) (57)
- A clamp-like biohybrid catalyst for DNA oxidation. (2013) (56)
- Role of a solvent‐exposed tryptophan in the recognition and binding of antibiotic substrates for a metallo‐β‐lactamase (2003) (56)
- Purification and characterization of human immunodeficiency virus type 1 reverse transcriptase. (1995) (55)
- Structural basis for amide hydrolysis catalyzed by the 43C9 antibody. (1999) (55)
- Gap misrepair mutagenesis: efficient site-directed induction of transition, transversion, and frameshift mutations in vitro. (1982) (55)
- Deletion of a highly motional residue affects formation of the Michaelis complex for Escherichia coli dihydrofolate reductase. (1998) (55)
- Synthesis and application of derivatizable oligonucleotides. (1987) (55)
- Preorganization and protein dynamics in enzyme catalysis. (2002) (55)
- Tracking sliding clamp opening and closing during bacteriophage T4 DNA polymerase holoenzyme assembly. (2000) (54)
- Targeting Tumour Proliferation with a Small‐Molecule Inhibitor of AICAR Transformylase Homodimerization (2012) (54)
- Mapping Protein-Protein Proximity in the Purinosome* (2012) (54)
- Strength of an interloop hydrogen bond determines the kinetic pathway in catalysis by Escherichia coli dihydrofolate reductase. (1998) (54)
- On the cofactor specificity of glycinamide ribonucleotide and 5-aminoimidazole-4-carboxamide ribonucleotide transformylase from chicken liver. (1981) (54)
- Kinetic analysis of nucleotide incorporation and misincorporation by Klenow fragment of Escherichia coli DNA polymerase I. (1995) (53)
- Lab-on-a-chip technologies for single-molecule studies. (2013) (53)
- Detection of dihydrofolate reductase conformational change by FRET using two fluorescent amino acids. (2013) (53)
- The carboxyl terminus of the bacteriophage T4 DNA polymerase is required for holoenzyme complex formation. (1996) (53)
- ADP-mediated dissociation of stable complexes of recA protein and single-stranded DNA. (1983) (52)
- Fidelity of in vitro DNA strand transfer reactions catalyzed by HIV-1 reverse transcriptase. (1994) (52)
- Role of adenosine 5'-triphosphate hydrolysis in the assembly of the bacteriophage T4 DNA replication holoenzyme complex. (1996) (52)
- Using an AraC-based three-hybrid system to detect biocatalysts in vivo (2000) (52)
- Cyanotryptophans as Novel Fluorescent Probes for Studying Protein Conformational Changes and DNA-Protein Interaction. (2015) (51)
- Evolution of highly active enzymes by homology-independent recombination. (2005) (51)
- A kinetic study of wild-type and mutant dihydrofolate reductases from Lactobacillus casei. (1989) (51)
- Cloning and characterization of a new purine biosynthetic enzyme: a non-folate glycinamide ribonucleotide transformylase from E. coli. (1994) (50)
- A multifunctional protein possessing glycinamide ribonucleotide synthetase, glycinamide ribonucleotide transformylase, and aminoimidazole ribonucleotide synthetase activities in de novo purine biosynthesis. (1985) (50)
- Interloop contacts modulate ligand cycling during catalysis by Escherichia coli dihydrofolate reductase. (2001) (50)
- A rapid screen of active site mutants in glycinamide ribonucleotide transformylase. (1996) (50)
- Subcloning, characterization, and affinity labeling of Escherichia coli glycinamide ribonucleotide transformylase. (1990) (50)
- Escherichia coli dihydrofolate reductase catalyzed proton and hydride transfers: Temporal order and the roles of Asp27 and Tyr100 (2014) (50)
- Bacteriophage T4 Dda Helicase Translocates in a Unidirectional Fashion on Single-stranded DNA (*) (1995) (50)
- Effects of distal point-site mutations on the binding and catalysis of dihydrofolate reductase from Escherichia coli. (1989) (49)
- Single-molecule mechanical identification and sequencing (2012) (49)
- Identification and Mapping of Protein-Protein Interactions between gp32 and gp59 by Cross-linking* (2001) (49)
- Interaction of Escherichia coli DNA polymerase I with azidoDNA and fluorescent DNA probes: identification of protein-DNA contacts. (1990) (48)
- Fluorescent oligonucleotides and deoxynucleotide triphosphates: preparation and their interaction with the large (Klenow) fragment of Escherichia coli DNA polymerase I. (1989) (48)
- A zinc ribbon protein in DNA replication: primer synthesis and macromolecular interactions by the bacteriophage T4 primase. (2001) (48)
- Phenylalanine hydroxylase from Chromobacterium violaceum is a copper-containing monooxygenase. Kinetics of the reductive activation of the enzyme. (1986) (48)
- Site-directed mutagenesis of a catalytic antibody: an arginine and a histidine residue play key roles. (1994) (48)
- On the solution structure of the T4 sliding clamp (gp45). (2004) (47)
- Stoichiometry and DNA Unwinding by the Bacteriophage T4 41:59 Helicase* (1996) (47)
- Mechanism of DNA polymerase I: exonuclease/polymerase activity switch and DNA sequence dependence of pyrophosphorolysis and misincorporation reactions. (1986) (47)
- The transformylase enzymes of de novo purine biosynthesis (1984) (47)
- Multimeric Structure of the Secreted Meprin A Metalloproteinase and Characterization of the Functional Protomer* (2001) (46)
- The kinetic mechanism of wild-type and mutant mouse dihydrofolate reductases. (1990) (46)
- Stability of the human polymerase δ holoenzyme and its implications in lagging strand DNA synthesis (2016) (46)
- On the mechanism of action of phenylalanine hydroxylase. (1981) (45)
- Assembly of the bacteriophage T4 primosome: single-molecule and ensemble studies. (2005) (45)
- L(-)-10-Formyltetrahydrofolate is the cofactor for glycinamide ribonucleotide transformylase from chicken liver. (1981) (45)
- Stereochemical analysis of the methyl transfer catalyzed by cobalamin-dependent methionine synthase from Escherichia coli B (1986) (45)
- Truncating α-Helix E′ of p66 Human Immunodeficiency Virus Reverse Transcriptase Modulates RNase H Function and Impairs DNA Strand Transfer (*) (1995) (44)
- Clinical severity in Lesch-Nyhan disease: the role of residual enzyme and compensatory pathways. (2015) (44)
- LOVely enzymes – towards engineering light‐controllable biocatalysts (2009) (44)
- Dual role of the 44/62 protein as a matchmaker protein and DNA polymerase chaperone during assembly of the bacteriophage T4 holoenzyme complex. (1996) (44)
- Dissecting the order of bacteriophage T4 DNA polymerase holoenzyme assembly. (1998) (44)
- Selection of catalytic antibodies for a biosynthetic reaction from a combinatorial cDNA library by complementation of an auxotrophic Escherichia coli: antibodies for orotate decarboxylation. (1994) (43)
- Evidence for two interconverting protein isomers in the methotrexate complex of dihydrofolate reductase from Escherichia coli. (1991) (43)
- Catalytic mechanism of Escherichia coli glycinamide ribonucleotide transformylase probed by site-directed mutagenesis and pH-dependent studies. (1999) (43)
- Metallo-beta-lactamase: structure and mechanism. (1999) (43)
- Acoustofluidic Chemical Waveform Generator and Switch (2014) (42)
- Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid. (2003) (42)
- Cyclic Peptides, A Chemical Genetics Tool for Biologists (2005) (42)
- Single-molecule investigation of the T4 bacteriophage DNA polymerase holoenzyme: multiple pathways of holoenzyme formation. (2006) (42)
- Phenylalanine hydroxylase: absolute configuration and source of oxygen of the 4a-hydroxytetrahydropterin species. (1985) (42)
- [60] Fructose-1,6-diphosphatase from rabbit liver (1975) (41)
- Molecular structure of Escherichia coli PurT-encoded glycinamide ribonucleotide transformylase. (2000) (41)
- Examination of the role of the clamp-loader and ATP hydrolysis in the formation of the bacteriophage T4 polymerase holoenzyme. (2003) (41)
- Nonadditivity of mutational effects at the folate binding site of Escherichia coli dihydrofolate reductase. (1994) (41)
- Substituent effects of an antibody-catalyzed hydrolysis of phenyl esters: further evidence for an acyl-antibody intermediate (1992) (41)
- Mechanism of "uncoupled" tetrahydropterin oxidation by phenylalanine hydroxylase. (1985) (41)
- The Interconversion of the 5,6,7,8-Tetrahydro-, 7,8-Dihydro-, and Radical Forms of 6,6,7,7-Tetramethyldihydropterin. A Model for the Biopterin Center of Aromatic Amino Acid Mixed Function Oxidases (1984) (40)
- Interaction between the T4 helicase loading protein (gp59) and the DNA polymerase (gp43): unlocking of the gp59-gp43-DNA complex to initiate assembly of a fully functional replisome. (2005) (40)
- A universal, vector-based system for nucleic acid reading-frame selection. (2002) (40)
- Construction and characterization of a single-chain catalytic antibody. (1991) (40)
- Importance of a hydrophobic residue in binding and catalysis by dihydrofolate reductase. (1986) (39)
- Hydrophobic interactions via mutants of Escherichia coli dihydrofolate reductase: separation of binding and catalysis. (1989) (39)
- Serine transhydroxymethylase: evidence for a sequential random mechanism. (1977) (39)
- Detection of a catalytic antibody species acylated at the active site by electrospray mass spectrometry. (1995) (38)
- Site directed mutagenesis: a tool for enzyme mechanism dissection. (1990) (38)
- Genetic Selection of Cyclic Peptide Dam Methyltransferase Inhibitors (2008) (38)
- Assembly of the Bacteriophage T4 Helicase (2002) (38)
- Rapid assembly of the bacteriophage T4 core replication complex on a linear primer/template construct. (1993) (38)
- Expression of rat liver phenylalanine hydroxylase in insect cells and site-directed mutagenesis of putative non-heme iron-binding sites. (1993) (38)
- Active-site mapping and site-specific mutagenesis of glycinamide ribonucleotide transformylase from Escherichia coli. (1990) (38)
- Protein-Protein Interactions in the Bacteriophage T4 Replisome (2003) (37)
- Molecular basis for nonadditive mutational effects in Escherichia coli dihydrofolate reductase. (1995) (37)
- ELECTROSTATIC CHARACTERIZATION OF ENZYME COMPLEXES : EVALUATION OF THE MECHANISM OF CATALYSIS OF DIHYDROFOLATE REDUCTASE (1997) (37)
- Magnetic tweezers for the study of DNA tracking motors. (2010) (37)
- Phenylalanine hydroxylase: structural determination of the tetrahydropterin intermediates by carbon-13 NMR spectroscopy (1982) (36)
- Creation of a novel biosensor for zinc(II) (1994) (36)
- Dissection of an antibody-catalyzed reaction. (1994) (36)
- Dynamic protein interactions in the bacteriophage T4 replisome. (2001) (36)
- Principles of antibody catalysis (1988) (35)
- Protein Conformational Changes Are Detected and Resolved Site Specifically by Second-Harmonic Generation (2015) (35)
- Architecture of the bacteriophage T4 primosome: electron microscopy studies of helicase (gp41) and primase (gp61). (2005) (35)
- Stereochemistry of acetic acid formation from 5-methyltetrahydrofolate by Clostridium thermoaceticum (1987) (35)
- Eukaryotic Translesion DNA Synthesis on the Leading and Lagging Strands: Unique Detours around the Same Obstacle. (2017) (35)
- Human AICAR transformylase: role of the 4-carboxamide of AICAR in binding and catalysis. (2000) (35)
- Interaction between the T4 helicase-loading protein (gp59) and the DNA polymerase (gp43): a locking mechanism to delay replication during replisome assembly. (2005) (35)
- Effect of accessory proteins on T4 DNA polymerase replication fidelity. (1998) (34)
- Mechanism-based inhibition of an essential bacterial adenine DNA methyltransferase: rationally designed antibiotics. (2001) (34)
- Combinatorial manipulation of three key active site residues in glycinamide ribonucleotide transformylase. (1997) (34)
- Microtubule-directed transport of purine metabolons drives their cytosolic transit to mitochondria (2018) (34)
- Mechanistic aspects of DNA polymerases: Escherichia coli DNA polymerase I (Klenow fragment) as a paradigm (1990) (34)
- A novel combined chemical-enzymatic synthesis of cross-linked DNA using a nucleoside triphosphate analogue. (1991) (34)
- New insights into inhibitor design from the crystal structure and NMR studies of Escherichia coli GAR transformylase in complex with beta-GAR and 10-formyl-5,8,10-trideazafolic acid. (1999) (34)
- Assembly of an active enzyme by the linkage of two protein modules. (1997) (33)
- A pH-dependent stabilization of an active site loop observed from low and high pH crystal structures of mutant monomeric glycinamide ribonucleotide transformylase at 1.8 to 1.9 A. (1998) (33)
- Intricacies in ATP-dependent clamp loading: variations across replication systems. (2001) (32)
- Identification of the Active Oligomeric State of an Essential Adenine DNA Methyltransferase from Caulobacter crescentus * (2001) (32)
- Probing the functional role of threonine-113 of Escherichia coli dihydrofolate reductase for its effect on turnover efficiency, catalysis, and binding. (1989) (32)
- Use of inteins for the in vivo production of stable cyclic peptide libraries in E. coli. (2003) (32)
- Stereoselective synthesis and biological activity of .beta.- and .alpha.-D-arabinose 1,5-diphosphate: analogs of a potent metabolic regulator (1984) (32)
- Characterization of human translesion DNA synthesis across a UV-induced DNA lesion (2016) (32)
- The Oligomeric T4 Primase Is the Functional Form during Replication* (2005) (31)
- Substrate form of D-frutose 1,6-bisphosphate utilized by fructose 1,6-bisphosphatase. (1977) (31)
- Unusual rate enhancement in metal ion catalysis of phosphate transfer (1971) (31)
- A multisubstrate adduct inhibitor of a purine biosynthetic enzyme with a picomolar dissociation constant. (1989) (31)
- The T4 Phage UvsW Protein Contains Both DNA Unwinding and Strand Annealing Activities* (2007) (31)
- Building a Replisome Solution Structure by Elucidation of Protein-Protein Interactions in the Bacteriophage T4 DNA Polymerase Holoenzyme* 210 (2001) (31)
- Anomerization rates and enzyme specificity for biologically important sugars and sugar phosphates (1978) (31)
- A new chemical synthesis of 2-amino-(N-D-ribofuranosyl)acetamide 5'-phosphate. (1977) (31)
- Clamp subunit dissociation dictates bacteriophage T4 DNA polymerase holoenzyme disassembly. (1998) (31)
- Design, synthesis, and biological evaluation of simplified alpha-keto heterocycle, trifluoromethyl ketone, and formyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase. (2003) (30)
- Protein-Protein and Protein-DNA Interactions at the Bacteriophage T4 DNA Replication Fork (1996) (30)
- Stepwise assembly of the human replicative polymerase holoenzyme (2013) (30)
- The function of amino acid residues contacting the nicotinamide ring of NADPH in dihydrofolate reductase from Escherichia coli. (1991) (30)
- Catalytic antibodies with acyl-transfer capabilities: mechanistic and kinetic investigations (1991) (30)
- PurT-encoded Glycinamide Ribonucleotide Transformylase (2002) (30)
- The effect of active-site isoleucine to alanine mutation on the DHFR catalyzed hydride-transfer. (2010) (29)
- Magnetic resonance studies of the anomeric distribution and manganese binding properties of fructose phosphates. (1972) (29)
- Capturing a sulfenic acid with arylboronic acids and benzoxaborole. (2013) (29)
- On the mechanisms of folate cofactors (1978) (29)
- 5-Formyl- and 10-formyl-5,6,7,8-tetrahydrofolate. Conformation of the tetrahydropyrazine ring and formyl group in solution. (1980) (29)
- Two pyrenylalanines in dihydrofolate reductase form an excimer enabling the study of protein dynamics. (2012) (29)
- Partial 1H NMR assignments of the Escherichia coli dihydrofolate reductase complex with folate: evidence for a unique conformation of bound folate. (1990) (29)
- Isothermal DNA amplification using the T4 replisome: circular nicking endonuclease-dependent amplification and primase-based whole-genome amplification (2010) (28)
- Response of the bacteriophage T4 replisome to noncoding lesions and regression of a stalled replication fork. (2010) (28)
- Stereochemistry of methylene transfer involving 5,10-methylenetetrahydrofolate. (1977) (28)
- An alternative clamp loading pathway via the T4 clamp loader gp44/62-DNA complex. (2006) (28)
- Implications for enzymic catalysis from free-energy reaction coordinate profiles. (1987) (28)
- Studies on models for tetrahydrofolic acid. 8. Hydrolysis and methoxyaminolysis of amidines (1977) (28)
- Development of an internally quenched fluorescent substrate for Escherichia coli leader peptidase. (1998) (28)
- Studies in sulfate esters. V. The mechanism of hydrolysis of phenyl phosphosulfate, a model system for 3'-phosphoadenosine 5'-phosphosulfate. (1970) (28)
- Formyl phosphate: a proposed intermediate in the reaction catalyzed by Escherichia coli PurT GAR transformylase. (1997) (28)
- STUDIES ON 6-METHYL-5-DEAZATETRAHYDROPTERIN AND ITS 4A ADDUCTS (1979) (28)
- Synthesis of (6R,11S)- and (6R,11R)-5,10-methylene[11-1H,2H]tetrahydrofolate. Stereochemical paths of serine hydroxymethyltransferase, 5,10-methylenetetrahydrofolate dehydrogenase, and thymidylate synthetase catalysis (1984) (27)
- RNA Primer Handoff in Bacteriophage T4 DNA Replication (2008) (27)
- Models for tetrahydrofolic acid. I. Condensation of formaldehyde with tetrahydroquinoxaline analogs (1969) (27)
- The Application of a Minicircle Substrate in the Study of the Coordinated T4 DNA Replication* (2003) (27)
- Stepwise loading of yeast clamp revealed by ensemble and single-molecule studies (2010) (27)
- Dark-Field Illumination on Zero-Mode Waveguide/Microfluidic Hybrid Chip Reveals T4 Replisomal Protein Interactions (2014) (27)
- Evaluation of the kinetic mechanism of Escherichia coli glycinamide ribonucleotide transformylase. (1998) (27)
- A free-energy perturbation study of the binding of methotrexate to mutants of dihydrofolate reductase. (1988) (27)
- Cloning and expression of Chromobacterium violaceum phenylalanine hydroxylase in Escherichia coli and comparison of amino acid sequence with mammalian aromatic amino acid hydroxylases. (1991) (27)
- Mechanistic studies on phenylalanine hydroxylase from Chromobacterium violaceum. Evidence for the formation of an enzyme-oxygen complex. (1989) (27)
- 10-Formyl-5,8,10-trideazafolic acid (10-formyl-TDAF): a potent inhibitor of glycinamide ribonucleotide transformylase. (1997) (27)
- Site‐specific mutagenesis of dihydrofolate reductase from Escherichia coli (1985) (27)
- A highly efficient chemical synthesis of Rp and Sp adenyl(3′-5′)adenyl-o,o-phosphorothioate (1980) (27)
- Mechanism of metal-independent hydroxylation by Chromobacterium violaceum phenylalanine hydroxylase. (1995) (27)
- Inactivation of DNA polymerase I (Klenow fragment) by adenosine 2',3'-epoxide 5'-triphosphate: evidence for the formation of a tight-binding inhibitor. (1989) (26)
- Studies on Sulfate Esters. II. Carboxyl Group Catalysis in the Hydrolysis of Salicyl Sulfate (1966) (26)
- Binding of hapten to a single-chain catalytic antibody demonstrated by electrospray mass spectrometry (1994) (26)
- Kinetic relationships between the various activities of the formyl-methenyl-methylenetetrahydrofolate synthetase. (1983) (26)
- Catalytic antibodies: perusing combinatorial libraries. (1994) (26)
- Effect of a thiobenzimidazolone derivative on DNA strand transfer catalyzed by HIV-1 reverse transcriptase. (1994) (26)
- 1H, 15N and 13C resonance assignments, secondary structure, and the conformation of substrate in the binary folate complex of Escherichia coli dihydrofolate reductase (1994) (26)
- Structural and mechanistic studies on the HeLa and chicken liver proteins that catalyze glycinamide ribonucleotide synthesis and formylation and aminoimidazole ribonucleotide synthesis. (1986) (26)
- Stereochemical course of the 3'----5'-exonuclease activity of DNA polymerase I. (1984) (25)
- Catalytic antibodies: mechanistic and practical considerations (1993) (25)
- Engineering specificity for folate into dihydrofolate reductase from Escherichia coli. (1996) (25)
- Investigations of an Antibody Ligase (1997) (25)
- Rational design of a scytalone dehydratase-like enzyme using a structurally homologous protein scaffold. (1999) (25)
- Dissociative Properties of the Proteins within the Bacteriophage T4 Replisome* (2003) (25)
- The effect of the 3',5' thiophosphoryl linkage on the exonuclease activities of T4 polymerase and the Klenow fragment. (1984) (25)
- Human de novo purine biosynthesis (2020) (24)
- Recent developments in catalytic antibodies. (1993) (24)
- The kinetics and mechanisms of phosphoenolpyruvate hydrolysis. (1968) (24)
- Intramolecular catalysis of sulfate ester hydrolysis. A model for aryl sulfate sulfohydrolase. (1970) (24)
- Mechanism of polynucleotide phosphorylase. (1989) (24)
- Investigation of Stoichiometry of T4 Bacteriophage Helicase Loader Protein (gp59)* (2009) (24)
- An antibody probe to determine the native species of glycinamide ribonucleotide transformylase in chicken liver. (1984) (24)
- Mechanism of bacteriophage T4 DNA holoenzyme assembly: the 44/62 protein acts as a molecular motor. (1997) (24)
- Dissociation of bacteriophage T4 DNA polymerase and its processivity clamp after completion of Okazaki fragment synthesis. (1997) (24)
- Template-prime-dependent turnover of (Sp)-dATP alpha S by T4 DNA polymerase. The stereochemistry of the associated 3' goes to 5'-exonuclease. (1982) (24)
- Antibody-catalyzed rearrangement of the peptide bond. (1992) (23)
- Spectroscopic Studies on the Designed Metal-Binding Sites of the 43C9 Single Chain Antibody? (1995) (23)
- Models for the tetrahydrofolic acid. IV. Reactions of amines with formamidinium tetrahydroquinoxaline analogs (1973) (23)
- Adduct formation between the cupric site of phenylalanine hydroxylase from Chromobacterium violaceum and 6,7-dimethyltetrahydropterin. (1987) (23)
- Structure of avian AICAR transformylase with a multisubstrate adduct inhibitor beta-DADF identifies the folate binding site. (2003) (23)
- Additions and Correcitons - Mechanisms of Hydrolysis of Phosphate Ester Derivatives of Phosphoenolpyruvic Acid (1971) (23)
- On the mechanism of action of fructose 1,6-diphosphatase. Inhibition by structural analogs of fructose 1,6-diphosphate. (1971) (23)
- Engineering an affinity tag for genetically encoded cyclic peptides. (2005) (23)
- Models for tetrahydrofolic acid. III. Hydrolytic interconversions of the tetrahydroquinoxaline analogs at the formate level of oxidation (1972) (22)
- The Mechanism of Phosphoryl Transfer (1978) (22)
- Unexpected Formation of an Epoxide Derived Multisubstrate Adduct Inhibitor on the Active Site of GAR Transformylase (2001) (22)
- Anomeric specificity of the alkaline form of fructose 1,6-diphosphatase from rabbit liver. (1974) (22)
- Tryptophan-based fluorophores for studying protein conformational changes. (2014) (22)
- Characterization of phenylalanine hydroxylase. (1986) (22)
- The Carboxyl Terminus of the Bacteriophage T4 DNA Polymerase Contacts Its Sliding Clamp at the Subunit Interface* (1999) (22)
- A revised strategy for cloning antibody gene fragments in bacteria. (1993) (22)
- Examination of the reactivity of benzoxaboroles and related compounds with a cis-diol. (2012) (21)
- Homology-independent protein engineering. (2000) (21)
- How a holoenzyme for DNA replication is formed (2012) (21)
- Assignment of a third purine biosynthetic gene (glycinamide ribonucleotide transformylase) to human chromosome 21. (1986) (21)
- Single-molecule studies of DNA replisome function. (2010) (21)
- Resonance energy transfer measurements between substrate binding sites within the large (Klenow) fragment of Escherichia coli DNA polymerase I. (1989) (21)
- X-ray absorption studies of the Cu-dependent phenylalanine hydroxylase from Chromobacterium violaceum. Comparison of the copper coordination in oxidized and dithionite-reduced enzymes. (1992) (21)
- Kinetic and structural characterization of dihydrofolate reductase from Streptococcus pneumoniae. (2010) (21)
- Studies on models for tetrahydrofolic acid. 7. Reactions and mechanisms of tetrahydroquinoxaline derivatives at the formaldehyde level of oxidation. (1976) (21)
- Multisubstrate adduct inhibitors of glycinamide ribonucleotide transformylase : synthetic and enzyme-assembled (1991) (21)
- Chemistry and biochemistry of pterins (1985) (20)
- Generation of a large combinatorial library of the immunoglobulin repertoire in phage lambda. 1989. (1992) (20)
- An examination of the copper requirement of phenylalanine hydroxylase from Chromobacterium violaceum. (1993) (20)
- The anomeric specificity of glycolytic enzymes. (1976) (20)
- On the mechanism of action of phenylalanine hydroxylase. (1985) (20)
- Purification and properties of an arylsulfatase from Aspergillus oryzae. (1971) (20)
- Computational studies on pterins and speculations on the mechanism of action of dihydrofolate reductase. (1989) (20)
- Substrate attenuation : an approach to improve antibody catalysis (1991) (19)
- Mechanisms of hydrolysis of phosphate ester derivatives of phosphoenolpyruvic acid. (1971) (19)
- Assembly and disassembly of DNA polymerase holoenzyme. (1997) (19)
- 5,10-Methylene-5,6,7,8-tetrahydrofolate. Conformation of the tetrahydropyrazine and imidazolidine rings. (1979) (19)
- The role of tryptophan in neutral fructose diphosphatase. (1974) (19)
- The binding of products, metal ion, and a substrate analog to rabbit liver fructose bisphosphatase. (1978) (19)
- Functionalized analogues of 5,8,10-trideazafolate: development of an enzyme-assembled tight binding inhibitor of GAR Tfase and a potential irreversible inhibitor of AICAR Tfase. (1997) (19)
- Characterization of mammalian phosphoribosylglycineamide formyltransferase from transformed cells. (1985) (19)
- Consideration of the pH-dependent inhibition of dihydrofolate reductase by methotrexate. (1997) (19)
- On the mechanism of decomposition of geminal diamines (1978) (19)
- Catalytic antibody for imide hydrolysis featuring a bifunctional transition-state mimic (1993) (19)
- Binding and kinetic data for rabbit liver fructose-1,6-bisphosphatase with Zn2+ as cofactor. (1978) (19)
- Anomeric specificity of phosphofructokinase from rabbit muscle. (1974) (19)
- Kinetic detection of the imminium cation in formaldehyde-amine condensations in neutral aqueous solution (1969) (19)
- Effect of divalent metal ions on the intramolecular nucleophilic catalysis of phosphate diester hydrolysis (1973) (18)
- Direct transfer of one-carbon units in the transformylations of de novo purine biosynthesis. (1982) (18)
- 10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway. (2002) (18)
- Replication protein A dynamically regulates monoubiquitination of proliferating cell nuclear antigen (2019) (18)
- Functionalized analogues of 5,8,10-trideazafolate as potential inhibitors of GAR Tfase or AICAR Tfase. (1997) (18)
- Purfication of glycineamide ribonucleotide transformylase. (1978) (18)
- Fructose 1,6-bisphosphate. Kinetics of hydrolysis catalyzed by rabbit liver neutral fructose-1,6-bisphosphatase with Mn2+. (1978) (18)
- Synthesis and separation of diastereomers of deoxynucleoside 5'-O-(1-thio)triphosphates. (1983) (18)
- Structural and functional modularity of proteins in the de novo purine biosynthetic pathway (2009) (18)
- Structural determination of quinonoid dihydropterins (1982) (18)
- Replication Protein A Prohibits Diffusion of the PCNA Sliding Clamp along Single-Stranded DNA (2017) (18)
- Complementary perturbation of the kinetic mechanism and catalytic effectiveness of dihydrofolate reductase by side-chain interchange. (1992) (18)
- The dynamics of DNA polymerase-catalyzed reactions. (1988) (17)
- Distances between structural metal ion, substrates, and allosteric modifier of fructose bisphosphatase. (1981) (17)
- Hydrolytic mechanisms of phosphoramidates of aromatic amino acids. (1967) (17)
- Kinetic and binding studies of Mn (II) and fructose 1,6-bisphosphate with rabbit liver hexosebisphosphatase. (1975) (17)
- Preliminary crystallographic investigations of glycinamide ribonucleotide transformylase. (1989) (17)
- Metabolic channeling: predictions, deductions, and evidence. (2021) (17)
- Mechanism of the idling-turnover reaction of the large (Klenow) fragment of Escherichia coli DNA polymerase I. (1986) (17)
- Active site topology of artificial peroxidase-like hemoproteins based on antibodies constructed from a specifically designed ortho-carboxy-substituted tetraarylporphyrin. (1998) (17)
- The state of antibody catalysis. (1997) (17)
- The anomeric form of D-fructose 1,6-bisphosphate used as substrate in the muscle and yeast aldolase reactions. (1975) (17)
- Catalysis of phosphoryl group transfer. The role of divalent metal ions in the hydrolysis of lactic acid O-phenyl phosphate and salicylic acid O-aryl phosphates. (1975) (17)
- The Human Lagging Strand DNA Polymerase δ Holoenzyme Is Distributive* (2012) (17)
- Mechanism of hydrolysis of phosphorylethanolamine diesters. Intramolecular nucleophilic amine participation (1980) (17)
- Metal ion catalysis of phosphoryl transfer from phosphoenolpyruvate. (1968) (17)
- Construction of hybrid gene libraries involving the circular permutation of DNA (2001) (16)
- Kinetic characterization of a bacteriophage T4 antimutator DNA polymerase. (1998) (16)
- Coordinated DNA Replication by the Bacteriophage T4 Replisome (2015) (16)
- Biotin and the nucleophilicity of 2-methoxy-2-imidazoline toward the sp2 carbonyl carbon (1969) (16)
- Biochemistry. Enzyme motions inside and out. (2006) (16)
- Isotope-tapping experiments with rabbit liver fructose bisphosphatase. (1978) (16)
- Affinity labeling of the active site and the reactive sulfhydryl associated with activation of rat liver phenylalanine hydroxylase. (1991) (16)
- Intramolecular and divalent metal ion catalysis. The hydrolytic mechanism of O-phenyl N-(glycyl)phosphoramidate. (1973) (16)
- Fluorescent biphenyl derivatives of phenylalanine suitable for protein modification. (2013) (16)
- Unambiguous stereochemical course of rabbit liver fructose bisphosphatase hydrolysis. (1985) (16)
- Analysis of the Stoichiometry of the T4 Gene 45 Protein by Ion Spray Mass Spectrometry (1994) (15)
- Tautomeric nature of quinonoid 6,7-dimethyl-7,8-dihydro-6H-pterin in aqueous solution: a nitrogen-15 NMR study (1985) (15)
- Design, synthesis and biological evaluation of 10-CF3CO-DDACTHF analogues and derivatives as inhibitors of GAR Tfase and the de novo purine biosynthetic pathway. (2003) (15)
- Nutritional, pharmacological, and physiological aspects (1986) (15)
- Abenzyl 10-formyl-trideazafolic acid (abenzyl 10-formyl-TDAF): an effective inhibitor of glycinamide ribonucleotide transformylase. (1997) (15)
- Design, synthesis, and evaluation of potential GAR and AICAR transformylase inhibitors. (1998) (15)
- Catalytic Antibodies in Synthesis: Design and Synthesis of a Hapten for Application to the Preparation of a Scalemic Pyrrolidine Ring Synthon for Ptilomycalin A (1996) (15)
- Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase. (2001) (15)
- Evaluation of the catalytic mechanism of AICAR transformylase by pH-dependent kinetics, mutagenesis, and quantum chemical calculations. (2001) (15)
- Understanding DNA replication by the bacteriophage T4 replisome (2017) (15)
- Spatial relationship between polymerase and exonuclease active sites of phage T4 DNA polymerase enzyme. (1994) (14)
- Hypoxia drives the assembly of the multienzyme purinosome complex (2020) (14)
- Site-directed Mutations of T4 Helicase Loading Protein (gp59) Reveal Multiple Modes of DNA Polymerase Inhibition and the Mechanism of Unlocking by gp41 Helicase* (2006) (14)
- Dependence of mechanism on pH for deuterium-hydrogen exchange in 1-methyltetrazole-5-d. Transition metal ion catalysis of a deprotonation process. (1972) (14)
- Role of HSP90 in the Regulation of de Novo Purine Biosynthesis. (2018) (14)
- G-protein-coupled receptor regulation of de novo purine biosynthesis: a novel druggable mechanism (2013) (14)
- Expression of an Orotate Decarboxylating Catalytic Antibody Confers 5-Fluoroorotate Sensitivity to a Pyrimidine Auxotrophic Escherichia coli: An Example of Intracellular Prodrug Activation (1995) (14)
- L-[2,5-H2]phenylalanine, an alternate substrate for rat liver phenylalanine hydroxylase. (1988) (14)
- Localization of GAR transformylase in Escherichia coli and mammalian cells (2001) (14)
- Conformationally restricted analogues designed for selective inhibition of GAR Tfase versus thymidylate synthase or dihydrofolate reductase. (2000) (14)
- Selective modification of rabbit liver fructose bisphosphatase. (1980) (14)
- [6] Chromobacterium violaceum phenylalanine 4-monooxygenase (1987) (14)
- Boron-Containing Inhibitors of Synthetases (2011) (13)
- Studies on models for tetrahydrofolic acid. II. Additional observations on the mechanism for condensation of formaldehyde with tetrahydroquinoxaline analogs (1970) (13)
- Multisubstrate analogue based on 5,8,10-trideazafolate. (1997) (13)
- The Mechanism of Action of Phenylalanine Hydroxylase (1986) (13)
- Impact on catalysis of secondary structural manipulation of the alpha C-helix of Escherichia coli dihydrofolate reductase. (1991) (13)
- Phosphorothioate substrates for T4 RNA ligase. (1982) (13)
- On interpreting the inhibition of and catalysis by dihydrofolate reductase (1987) (13)
- Elucidation of the metal-binding properties of the Klenow fragment of Escherichia coli polymerase I and bacteriophage T4 DNA polymerase by lanthanide(III) luminescence spectroscopy. (1996) (13)
- Dihydrofolate reductase mutant with exceptional resistance to methotrexate but not to trimetrexate. (2003) (13)
- Combinatorial approaches to engineering hybrid enzymes (2002) (13)
- 31 P and 13 C nmr measurements of a fructose-1-phosphate, Mn (II) and fructose 1,6-diphosphatase complex. (1973) (13)
- Protein engineering of dihydrofolate reductase. pH dependency of Phe-31 mutants (1987) (12)
- On the mechanism of alkaline and neutral fructose 1, 6-diphosphatase: inhibition by substrate analogs at neutral pH. (1972) (12)
- The stereochemical course of thiophosphoryl group transfer catalyzed by T4 polynucleotide kinase. (1981) (12)
- Analysis of the DNA translocation and unwinding activities of T4 phage helicases. (2010) (12)
- Stereoselective chemical reduction of 5,10-methenyltetrahydrofolate (1973) (12)
- Preparation of 2-amino-4(3H)-oxopyrimido[5,4-b] [1,4]thiazines (5-thiapterins) and their evaluation as cofactors for phenylalanine hydroxylase. (1983) (12)
- Mechanism of hydrolysis of phosphorylethanolamine triesters. Multiple catalytic effects of an intramolecular amino group (1979) (12)
- Processive and unidirectional translocation of monomeric UvsW helicase on single-stranded DNA. (2009) (12)
- Synthesis of 5,11-methenyltetrahydrohomofolate and its antifolate activity in vitro. (1981) (12)
- On the mechanism of fructose 1,6-diphosphatase: inhibition by methyl D-fructoside 1,6-diphosphate. (1970) (12)
- Identification of metal ligands in Cu(II)-inhibited Chromobacterium violaceum phenylalanine hydroxylase by electron spin echo envelope modulation analysis of histidine to serine mutations. (1994) (12)
- On the mechanism of T4 RNA ligase (1981) (11)
- Fructose 1,6-bisphosphatase from rabbit liver. [18O]Phosphate-H2O exchange as a probe of the catalytic mechanism. (1979) (11)
- The effect of arabinose 1,5-bisphosphate on rat hepatic 6-phosphofructo-1-kinase and fructose-1,6-bisphosphatase. (1986) (11)
- A nonradioactive DNA methyltransferase assay adaptable to high-throughput screening. (2005) (11)
- Improvement in the efficiency of formyl transfer of a GAR transformylase hybrid enzyme. (2000) (11)
- On the physical properties and mechanism of action of arylsulfate sulfohydrolase II from Aspergillus oryzae. (1975) (11)
- Insights into Okazaki Fragment Synthesis by the T4 Replisome (2013) (11)
- Antibody-Catalyzed Rearrangement of a Peptide Bond: Mechanistic and Kinetic Investigations (1995) (11)
- Biocatalysts — the next generation (1997) (11)
- Probing DNA clamps with single-molecule force spectroscopy (2013) (10)
- Investigation of the pre-steady-state kinetics of fructose bisphosphatase by employment of an indicator method. (1979) (10)
- The key is in the pocket (1996) (10)
- Pentacovalent phosphorus in the hydrolysis of dibenzylphosphoenolpyruvate (1969) (10)
- A multisubstrate adduct inhibitor of AICAR transformylase. (1999) (10)
- Monitoring the Retention of Human Proliferating Cell Nuclear Antigen at Primer/Template Junctions by Proteins That Bind Single-Stranded DNA. (2017) (10)
- Behavior of a cross-linked attachment site: testing the role of branch migration in site-specific recombination. (1991) (10)
- Expanding the 43C9 class of catalytic antibodies using a chain-shuffling approach. (1997) (10)
- The synthesis and properties in enzymic reactions of substrate analogs containing the methylphosphonyl group. (1979) (10)
- Studies on models for tetrahydrofolic acid. V.A. kinetically significant transport process in general base catalyzed aminolysis of a formamidine. (1974) (10)
- A two-phagemid system for the creation of non-phage displayed antibody libraries approaching one trillion members. (2000) (9)
- Novel phosphonothioate substrates for phosphodiesterases. (1977) (9)
- Design, synthesis, and biological evaluation of fluoronitrophenyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase. (2000) (9)
- The Purinosome, a Multi-Protein Complex Involved in the de novo Biosynthesis of Purines in Humans (2013) (9)
- Stereospecificity of thymidylate synthetase (1977) (9)
- Cyclic peptide formation catalyzed by an antibody ligase. (2000) (9)
- Repetitive lagging strand DNA synthesis by the bacteriophage T4 replisome. (2008) (9)
- Abstracts, Division of Biological Chemistry, 194th National Meeting of the American Chemical Society, August 30 - September 4, 1987 (1987) (8)
- Interaction of T4 UvsW helicase and single-stranded DNA binding protein gp32 through its carboxy-terminal acidic tail. (2013) (8)
- Kinetic and structural investigations of the replicative fidelity of the Klenow fragment. (1988) (8)
- Evidence that the folate-requiring enzymes of de novo purine biosynthesis are encoded by individual mRNAs. (1984) (8)
- Anomeric specificity of yeast pyruvate kinase toward activation by D-fructose 1,6-bisphosphate (1975) (8)
- Temporally overlapped but uncoupled motions in dihydrofolate reductase catalysis. (2013) (8)
- T4 Phage Replisome (2009) (8)
- Rapid-quench and isotope-trapping studies on fructose-1,6-bisphosphatase. (1982) (7)
- Screening combinatorial antibody libraries for catalytic acyl transfer reactions. (1991) (7)
- Protein Engineering of Dihydrofolate Reductase. Improved Catalytic Step of Mutant-Enzymes (1987) (7)
- The mechanism of phenylalanine hydroxylase. (1982) (7)
- Threading your way to protein function. (1996) (7)
- Stereochemical Analysis of the Methyl Transfer Catalyzed by Cobalamin-Dependent Methionine Synthase from Escherichia coli B. (1987) (7)
- Synthesis and biological evaluation of N-[4-[5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoroacetyl)pentyl]benzoyl]-L-glutamic acid as a potential inhibitor of GAR Tfase and the de novo purine biosynthetic pathway. (2005) (7)
- Identifying Small‐Molecule Modulators of Protein‐Protein Interactions (2006) (7)
- 4 Analysis of Protein Function by Mutagenesis (1990) (7)
- Mapping Post-Translational Modifications of de Novo Purine Biosynthetic Enzymes: Implications for Pathway Regulation. (2019) (7)
- A combinatorial system for cloning and expressing the catalytic antibody repertoire in Escherichia coli. (1989) (7)
- On the structural and functional modularity of glycinamide ribonucleotide formyltransferases (2003) (7)
- Expression of the purine biosynthetic enzyme phosphoribosyl formylglycinamidine synthase in neurons (2018) (7)
- Studies on sulfate esters. III. A comparison of the solvolyses of salicyl sulfate and sulfur trioxide (1968) (7)
- Understanding Enzyme Mechanism through Protein Chimeragenesis (2009) (6)
- Design, synthesis, and biological evaluation of 10-methanesulfonyl-DDACTHF, 10-methanesulfonyl-5-DACTHF, and 10-methylthio-DDACTHF as potent inhibitors of GAR Tfase and the de novo purine biosynthetic pathway. (2005) (6)
- Production of Cyclic Proteins and Peptides (2005) (6)
- PCNA monoubiquitination is regulated by diffusion of Rad6/Rad18 complexes along RPA filaments (2020) (6)
- RNA primer–primase complexes serve as the signal for polymerase recycling and Okazaki fragment initiation in T4 phage DNA replication (2017) (6)
- THE INTERCONVERSION OF THE 5,6,7,8-TETRAHYDRO-, 6,7,8-DIHYDRO-, AND RADICAL FORMS OF 6,6,7,7-TETRAMETHYLDIHYDROPTERIN. A MODEL FOR THE BIOPTERIN CENTER OF AROMATIC AMINO ACID MIXED FUNCTION OXIDASES (1985) (6)
- Inhibition of HKSV28 cell growth by 5,11-methenyl-tetrahydrohomofolate. (1984) (6)
- The mechanism of oxidation of 6-methyl-5-carba-5-deazatetrahydropterin. Evidence for the involvement cf a 4a-adduct in the oxidation of tetrahydropterins. (1978) (5)
- The use of modified and non-natural nucleotides provide unique insights into pro-mutagenic replication catalyzed by polymerase eta (2015) (5)
- Purine biosynthetic enzymes assemble into liquid-like condensates dependent on the activity of chaperone protein HSP90 (2022) (5)
- Chapter 1 Hydrolytic Reactions of Inorganic Esters (1972) (5)
- The reaction of nucleophilic species with quinonoid 6,6,7,7-tetramethyldihydropterin (1986) (5)
- Liver aldolase anomeric specificity. (1980) (5)
- Synthesis and biological evaluation of alpha- and gamma-carboxamide derivatives of 10-CF3CO-DDACTHF. (2005) (5)
- Generation and thiol reduction of a "quinonoid" dihydropterin and an oxidized pyrimidine analog (1979) (5)
- Anomeric specificity of carbohydrate-utilizing enzymes. (1979) (5)
- A convenient synthesis of 2S, 3S‐[3‐2H]‐serine and 2S, 3R‐[2, 3‐2H2]‐serine (1982) (5)
- Stereochemical and kinetic investigation of 32P-labeled inorganic phosphate exchange reaction catalyzed by primer-independent and primer-dependent polynucleotide phosphorylase from Micrococcus luteus. (1981) (5)
- Using incremental truncation to create libraries of hybrid enzymes. (2004) (5)
- The Purinosome: A Case Study for a Mammalian Metabolon. (2022) (5)
- 10-(2-benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid: a potential inhibitor of GAR transformylase and AICAR transformylase. (2003) (5)
- Expression of properly folded catalytic antibodies in Escherichia coli. (1995) (4)
- Detecting Purinosome Metabolon Formation with Fluorescence Microscopy. (2018) (4)
- Observations in the Interface Between Immunology and Chemistry (1990) (4)
- Recognition of a Key Anchor Residue by a Conserved Hydrophobic Pocket Ensures Subunit Interface Integrity in DNA Clamps. (2019) (4)
- Inhibition of chicken liver 5-aminoimidazole-4-carboxamide ribonucleotide transformylase by 5,8-dideaza analogues of folic acid. (1988) (4)
- [14] Anomeric specificity of carbohydrate-utilizing enzymes (1979) (4)
- Multienzyme interactions of the de novo purine biosynthetic protein PAICS facilitate purinosome formation and metabolic channeling (2022) (4)
- Synthesis of [4a‐13C]‐6‐methyltetrahydropterin (1982) (4)
- Stopped-Flow Apparatus for a Zeiss PMQ II Spectrophotometer (1965) (4)
- Engineering Protein Evolution (2003) (4)
- A new synthesis of double labeled [7, 9 ‐13C2] folic acid (1994) (4)
- Mechanism of DNA Polymerase I (1991) (4)
- SYNTHESIS OF (6R,11S)- AND (6R,11R)-5,10-METHYLENE(11-1H,2H)TETRAHYDROFOLATE. STEREOCHEMICAL PATHS OF SERINE HYDROXYMETHYLTRANSFERASE, 5,10-METHYLENETETRAHYDROFOLATE DEHYDROGENASE, AND THYMIDYLATE SYNTHETASE CATALYSIS (1984) (3)
- 'Screw-cap' clamp loader proteins that thread (2004) (3)
- ATIC-Associated De Novo Purine Synthesis Is Critically Involved in Proliferative Arterial Disease (2022) (3)
- Insights into Enzymic Catalysis from Studies on Dihydrofolate Reductases (1989) (3)
- Kinetic hysteresis for fructose bisphosphatase: a change in substrate configuration specificity. (1979) (3)
- Histidines 138 and 143 are copper binding ligands in Chromobacterium violaceum phenylalanine hydroxylase. (1993) (3)
- Retracing Enzyme Evolution in the (βα)8‐Barrel Scaffold (2001) (3)
- Photochemical cross-linking of DNA replication proteins at primer terminus. (1995) (3)
- STEREOSELECTIVE SYNTHESIS AND BIOLOGICAL ACTIVITY OF β- AND α-D-ARABINOSE 1,5-DIPHOSPHATE: ANALOGS OF A POTENT METABOLIC REGULATOR (1985) (3)
- Catalytic Antibodies: Mechanistic and Practical Considerations. (1993) (3)
- Metal ion catalysis of phosphoryl hydrolysis from thiolphosphate monoesters (1972) (3)
- Dihydrofolate Reductase: Hydrogen Tunneling and Protein Motion (2007) (2)
- Additions and Corrections - Stereoselective Chemical Reduction of 5,10-Methenyltetrahydrofolate (1975) (2)
- Synthesis of two bi-functional ligands for the QUEST three-hybrid system (2000) (2)
- A chemiluminescent immunoassay for the identification of functional single-chain antibodies. (1995) (2)
- A re-examination of the metal requirement of Chromobacterium violaceum phenylalanine hydroxylase. (1993) (2)
- Purine synthesis suppression reduces the development and progression of pulmonary hypertension in rodent models. (2023) (2)
- Catalytic Antibodies in Synthesis: Design and Synthesis of a Hapten for Application to the Preparation of a Scalemic Pyrrolidine Ring Synthon for Ptilomycalin A. (1996) (2)
- Chromobacterium violaceum phenylalanine 4-monooxygenase. (1987) (2)
- Antibody catalysis. The key is in the pocket. (1996) (2)
- Mechanisms: molecular machines. (2011) (2)
- Catalytic Antibody Model And Site-Directed Mutagenesis Implicate Arginine And Histidine In Catalytic Mechanism (1993) (2)
- Architecture of the bacteriophage T 4 primosome : Electron microscopy studies of helicase ( gp 41 ) and primase ( gp 61 ) (2005) (2)
- Model reactions for catalysis of phosphate and sulfate transfer. (1970) (2)
- On the mechanism of de novo polymerization by form I polynucleotide phosphorylase of Micrococcus luteus. (1982) (2)
- Additions and Corrections - Stereoselective Synthesis and Biological Activity of β -and α-D-Arabinose 1,5-Diphosphate: Analogues of a Potent Metabolic Regulator (1985) (2)
- Continuous assay for DNA polymerization by light scattering. (1984) (2)
- Synthesis and biological evaluation of 9‐thia‐5,10‐dideazafolic acid (2002) (2)
- Open questions - in brief: Beyond -omics, missing motor proteins, and getting from molecules to organisms (2013) (2)
- Mechanisms Research highlights at the chemistry/biology interface (1997) (2)
- Structure of 6-(iodomethyl)-2-oxo-2-phenoxy-1,2-oxaphosphorinane. (1988) (2)
- STRUCTURE OF ESCHERICHIA COLI PURT-ENCODED GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE COMPLEXED WITH MG, AMPPNP, AND GAR (2000) (2)
- Catalytic antibodies. (1991) (2)
- A handy enzyme for transcription (1992) (2)
- Selection of tmRNA Inhibitors as Antibacterial and Plasmid Elimination Agents (2010) (1)
- Simultaneous formation of functional leading and lagging strand holoenzyme complexes on a small, defined DNA substrate. (1998) (1)
- Protein technologies and commercial enzymes (2000) (1)
- DNA Replication Fork, Bacterial (2013) (1)
- Mechanisms of folate cofactors (1977) (1)
- Corrigendum to "The unique chemistry of benzoxaboroles: Current and emerging applications in biotechnology and therapeutic treatments" [Bioorg. Med. Chem. 22 (2014) 4462-4473] (2015) (1)
- Antibody‐Catalyzed Rearrangement of the Peptide Bond. (1993) (1)
- Cytochrome P 450 enzymes : understanding the biochemical hieroglyphs (2019) (1)
- GENERATION AND THIOL REDUCTION OF A “QUINONOID” DIHYDROPTERIN AND AN OXIDIZED PYRIMIDINE ANALOG (1980) (1)
- Chemistry and spectroscopy of copper monooxygenases (1992) (1)
- Synthesis and Biological Evaluation of 9‐Thia‐5,10‐dideazafolic Acid. (2003) (1)
- Author response: Stepwise assembly of the human replicative polymerase holoenzyme (2013) (1)
- Investigation of an antibody-ligase. Evidence for strain-induced catalysis. (2003) (1)
- Structure and dynamics of a DNA: polymerase complex by time-resolved fluorescence spectroscopy (1990) (1)
- Chapter 10 Transformations involving folate and biopterin cofactors (1984) (1)
- Mechanisms: Research highlights at the chemistry–biology interface: Editorial overview (1999) (1)
- Too fast for catalysis (2013) (1)
- Probing the molecular basis of resistance to pyrimethamine by site-directed mutagenesis. (1992) (1)
- Fructose-bisphosphatase, zinc-free, from rabbit liver. (1982) (1)
- Studies on models for tetrahydrofolic acid. 3. Hydrolytic interconversions of the tetrahydroquinoxaline analogs at the formate level of oxidation. (1972) (1)
- Frontiers in chemistry day: Oxygen bicentennial symposium (1975) (1)
- Direct demonstration of the active salvage of preformed purines by murine tumors. (1990) (1)
- CRYSTAL STRUCTURE OF AVIAN ATIC, A BIFUNCTIONAL TRANSFORMYLASE AND CYCLOHYDROLASE ENZYME IN PURINE BIOSYNTHESIS AT 1.75 ANG. RESOLUTION (2001) (0)
- Molecules containing an antibody connecting points and having stereospecific catalysis (1991) (0)
- Through the Glass Lightly (1995) (0)
- Using transcriptional-based systems for in vivo enzyme screening. (2003) (0)
- The Use of Combinatorial Heavy and Light Chain Libraries and Site Specific Mutagenesis to Create Antibody Biosensors for Metal Ions. (1992) (0)
- Future Directions of Catalysis Science—Workshop (2001) (0)
- Molecules avec sites de combinaison d'anticorps presentant une catalyse stereospecifique (1990) (0)
- The Gowland Hopkins Lecture: The Mechanisms of Action of Folate and Pterin Requiring Enzymes (1986) (0)
- The Mechanism of Action of the Transformylase Enzymes (1983) (0)
- Direct Observation of Stalled Fork Restart and Lesion Bypass via Fork Regression in the T4 Replication System (2013) (0)
- Model reactions for catalysis of phosphate and sulfate transfer. (1970) (0)
- Monitoring the Retention of Human PCNA at Primer/Template junctions by Proteins that Bind Single-stranded DNA (2017) (0)
- 1SM-04 Studying molecular motors with optical and magnetic tweezers(1SM Interdisciplinary research around single molecule studies; delving into and going beyond comfort zone,The 49th Annual Meeting of the Biophysical Society of Japan) (2011) (0)
- STUDIES ON MODELS FOR TETRAHYDROFOLIC ACID PART 5, A KINETICALLY SIGNIFICANT TRANSPORT PROCESS IN GENERAL BASE CATALYZED AMINOLYSIS OF A FORMAMIDINE (1975) (0)
- A bio-hybrid rotaxane catalyst (2017) (0)
- Report on Discussions (1983) (0)
- Peptide Bond Formation via Catalytic Antibodies: Synthesis of a Novel Phosphonate Diester Hapten. (2010) (0)
- Abstracts, Division of Biological Chemistry, 3rd Chemical Congress of North America and 195th National Meeting of the American Chemical Society, June 5 - 10, 1988 (1988) (0)
- Mechanism of Yeast Clamp Loading on DNA (2011) (0)
- [53] Fructose-bisphosphatase, zinc-free, from rabbit liver (1982) (0)
- Thomas Bruice (1925–2019) (2019) (0)
- In This Issue (2009) (0)
- STUDIES ON MODELS FOR TETRAHYDROFOLIC ACID. 7. REACTIONS AND MECHANISMS OF TETRAHYDROQUINOXALINE DERIVATIVES AT THE FORMALDEHYDE LEVEL OF OXIDATION (1976) (0)
- Adventures in trying to understand enzymic catalysis (1996) (0)
- THE MECHANISM OF OXIDATION OF 6-METHYL-5-CARBA-5-DEAZATETRAHYDROPTERIN. EVIDENCE FOR THE INVOLVEMENT OF A 4A-ADDUCT IN THE OXIDATION OF TETRAHYDROPTERINS (1978) (0)
- Erratum: X-ray absorption studies of the Cu-dependent phenylalanine hydroxylase from chromobacterium violaceum. Comparison of the copper coordination in oxidized and dithionite-reduced enzymes (Biochemistry (June 16, 1992) 31:23 (5298-5303)) (1993) (0)
- Crystal structure of glycniamide ribonucleotide transformylase in complex with Mg-ATP-gamma-S (2002) (0)
- PREPARATION OF 2-AMINO-4(3H)-OXOPYRIMIDO(5,4-B)(1,4)THIAZINES (5-THIAPTERINS) AND THEIR EVALUATION AS COFACTORS FOR PHENYLALANINE HYDROXYLASE (1983) (0)
- Crystal structure of purt-encoded glycinamide ribonucleotide transformylase complexed with Mg-ATP (2002) (0)
- Open questions - in brief: Beyond -omics, missing motor proteins, and getting from molecules to organisms (2013) (0)
- NOVEL PHOSPHONOTHIOATE SUBSTRATES FOR PHOSPHODIESTERASES (1977) (0)
- POLY 579-Artificial processive enzymes based on the T4 replisome (2006) (0)
- Mechanistic Studies on DNA Polymerase I (1988) (0)
- Mechanistic Studies on Phenylalanine Hydroxylase: Structural Determination of the Tetrahydropterin Intermediates (1983) (0)
- Fructose-1, 6-diphosphatase from rabbit liver. (1975) (0)
- Erratum: Mechanisms of hydrolysis of phosphate ester derivatives of phosphoenolpyruvic acid (Journal of the American Chemical Society (1971) 93, (2522)) (1971) (0)
- Peptide cyclization intein-mediated. (1999) (0)
- The transformylase enzymes of de novo purine bi osy n t h esis (1996) (0)
- fhe effect of the 3' ,5' thophosphoryl linkage on the exonudease actvities of T4 polymerase and the Kienow fragment (0)
- Glossary of Coined Names & Terms Used in Science (2011) (0)
- Macrocycles and Antibodies as Catalysts (2007) (0)
- Metal Ion-Activated Enzymes (1973) (0)
- Catalytic antibodies. (1987) (0)
- Through the Glass Lightly (1995) (0)
- Part II. Summary (1999) (0)
- Towards rational drug design: crystal structures of glycinamide ribonucleotide transformylase (1996) (0)
- Perspectives on biological catalysis (2017) (0)
- Erratum: Conformational changes in the active site loops of dihydrofolate reductase during the catalytic cycle (Biochemistry (December 28, 2004) 43:51 (16046-16055)) (2005) (0)
- From Bioorganic Models to Cells. (2021) (0)
- STUDIES ON MODELS FOR TETRAHYDROFOLIC ACID PART 4, REACTIONS OF AMINES WITH FORMAMIDINIUM TETRAHYDROQUINOXALINE ANALOGS (1974) (0)
- Characterization of the T 4 Mre 11 / Rad 50 complex and investigation of the Mre 11 dimeric interface (2017) (0)
- Forward and Backward Motion of Replicative Polymerases and Their Coupling with the Helicase (2011) (0)
- Observations on the Cellular Dynamics of a Metabolic Complex, the Purinosome (2016) (0)
- Quantitative Analysis of Purine Nucleotides Indicates Purinosome s Increase de N ovo Purine Biosynthesis (2015) (0)
- Biohybrid DNA nuclease mimic (2013) (0)
- Erratum: Assembly of the bacteriophage T4 primosome: Single-molecule and ensemble studies (Proceedings of the National Academy of Sciences of the United States of America (March 1, 2005) 102, 9 (3254-3259)) (2005) (0)
- Control of Enzyme Activity by a Light-Sensing Signaling Domain (2011) (0)
- Catalytic Antibodies with Acyl‐Transfer Capabilities: Mechanistic and Kinetic Investigations. (1991) (0)
- CAT AL YTIC ANTIBODIES (1992) (0)
- LEUCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH A tRNA(leu) transcript with 5-FLUORO-1,3-DIHYDRO-1-HYDROXY-2,1- BENZOXABOROLE (AN2690) forming an adduct to the ribose of adenosine- 76 in the enzyme editing site. (2007) (0)
- Crystal Structure of PurT-Encoded Glycinamide Ribonucleotide Transformylase in Complex with Mg-ATP and GAR (2002) (0)
- Kinetics and Mechanisms (1973) (0)
- A process for the manipulation of nucleic acids (2002) (0)
- No Job Name (2005) (0)
- CRYSTAL STRUCTURE OF THE HOMODIMERIC BIFUNCTIONAL TRANSFORMYLASE AND CYCLOHYDROLASE ENZYME AVIAN ATIC IN COMPLEX WITH A MULTISUBSTRATE ADDUCT INHIBITOR BETA-DADF. (2003) (0)
- Crystal structure of a 'humanized' E. coli dihydrofolate reductase (2013) (0)
- Site-Specific Mutations in Dihydrofolate Reductase at the Dihydrofolate Binding Site (1987) (0)
- Unnatural translation initiation. (2008) (0)
- Catalytic antibodies. (1992) (0)
- Catecholate LMCT Bands as Probes for the Active Sites of Nonheme Iron Oxygenases. (1988) (0)
- Retracing Enzyme Evolution in the (betaalpha)(8)-Barrel Scaffold. (2001) (0)
- Current Topics DNA Polymerase Fidelity : Kinetics , Structure , and Checkpoints † (0)
- Corrections: X-ray Absorption Studies of the Cu-Dependent Phenylalanine Hydroxylase from Chromobacterium violaceum. Comparison of the Copper Coordination in Oxidized and Dithionite-Reduced Enzymes (Biochemistry (1992) 31(23) (5298–5303) (10.1021/bi00138a008)) (1993) (0)
- High-throughput single molecule detection using nanophotonic/microfluidic hybrid chip (2014) (0)
- A catalytic antibody uses a multistep kinetic sequence. (1991) (0)
- THE STEREOCHEMICAL COURSE OF SEVERAL ENZYME CATALYZED REACTIONS AT THE PHOSPHODIESTER LEVEL (1980) (0)
- Artificial Processive Enymes based on the T4 Replisome (2006) (0)
- Behavior Of The T4 Bacteriophage Primosome: Helicase Motion And Its Coupling With Primase (2009) (0)
- Cytochrome P 450 enzymes : understanding the biochemical (2018) (0)
- Author response: Characterization of human translesion DNA synthesis across a UV-induced DNA lesion (2016) (0)
- Structural basis of the T4 bacteriophage primosome assembly and primer synthesis (2023) (0)
- The mechanism of formylation of five-membered cyclic phosphorodiamidates. (1975) (0)
- STEREOSELECTIVE CHEMICAL REDUKTION OF 5,10-METHENYL-TETRAHYDROFOLATE (1973) (0)
- Corrections - Investigation of the Pre-Steady-State Kinetics of Fructose Biphosphatase by Employment of an Indicator Method (1979) (0)
- LEUCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH A SULPHAMOYL ANALOGUE OF LEUCYL-ADENYLATE In the synthetic site and an adduct of AMP with 5-Fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (AN2690) in the editing site (2007) (0)
- Catalysis by lmidazole and by the Imidazol-4-ylacetate Ion in the Hydrolysis of Aryl Acetates (2016) (0)
- Studies of de novo Purine Biosynthetic Complexes in Living Cells (2008) (0)
- Metabolites imaging in single HeLa cells using GCIB-SIMS (2020) (0)
- SYNTHESIS OF 5,11-METHENYLTETRAHYDROHOMOFOLATE AND ITS ANTIFOLATE ACTIVITY IN VITRO (1982) (0)
- Future Directions of Catalysis Science—Workshop (2001) (0)
- The Unexpected Catalytic Properties of a Heterodimer of GAR Transformylase. (2000) (0)
- Folate and dihydrofolate reduction by mouse dihydrofolate reductase (1990) (0)
- Electrostatics of Active Site Microenvironments for E. coli DHFR (2014) (0)
- • Correlations between Enzyme Catalysis, Heterogeneous Catalysis and Homogeneous Catalysis • New Methods of Catalyst Synthesis • Characterization of Catalysts under Reaction Conditions • Global Catalytic Processes (2001) (0)
- Crystal structure of glycinamide ribonucleotide transformylase in complex with Mg-AMPPCP (2002) (0)
- SIMS (Imaging Secondary Ion Mass Spectrometry) Analysis of a Cross-section Sample From Leonardo Da Vinci’s Adoration of the Magi (2020) (0)
- Design, preparation and characterization of a de novo metal binding site in single chain catalytic antibody 43C9. (1993) (0)
- Mapping Purinosome Protein‐Protein Interactions Using In Vivo Photocrosslinking (2020) (0)
- human GAR Tfase in complex with hydrolyzed form of 10-trifluoroacetyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (2003) (0)
- DNA Replication by the Bacteriophage T 4 Replisome 1 Understanding DNA Replication by the Bacteriophage T 4 Replisome (2017) (0)
This paper list is powered by the following services:
Other Resources About Stephen J. Benkovic
What Schools Are Affiliated With Stephen J. Benkovic?
Stephen J. Benkovic is affiliated with the following schools:
