Stephen L. Mayo
#83,846
Most Influential Person Now
Professor of Biology and Chemistry
Stephen L. Mayo's AcademicInfluence.com Rankings
Download Badge
Chemistry Biology
Stephen L. Mayo's Degrees
- PhD Chemistry California Institute of Technology
- Bachelors Chemistry University of California, Berkeley
Why Is Stephen L. Mayo Influential?
(Suggest an Edit or Addition)According to Wikipedia, Stephen L. Mayo is a professor at the California Institute of Technology, where he is the William K. Bowes Jr. Leadership Chair in the Division of Biology and Biological Engineering, and the Bren Professor of Biology and Chemistry. His research focuses on structural biology and the development of computational methods for protein design. Mayo was elected to the United States National Academy of Sciences in 2004 and was appointed to a six-year term on the National Science Board in 2013.
Stephen L. Mayo's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- DREIDING: A generic force field for molecular simulations (1990) (4831)
- De novo protein design: fully automated sequence selection. (1997) (1047)
- Enzyme-like proteins by computational design (2001) (397)
- Design, structure and stability of a hyperthermophilic protein variant (1998) (358)
- Protein building blocks preserved by recombination (2002) (352)
- Protein design automation (1996) (299)
- Iterative approach to computational enzyme design (2012) (275)
- Probing the role of packing specificity in protein design. (1997) (259)
- Long-range electron transfer in heme proteins. (1986) (258)
- Precision is essential for efficient catalysis in an evolved Kemp eliminase (2013) (254)
- Automated design of the surface positions of protein helices (1997) (247)
- Energy functions for protein design. (1999) (225)
- Trading accuracy for speed: A quantitative comparison of search algorithms in protein sequence design. (2000) (212)
- Intrinsic beta-sheet propensities result from van der Waals interactions between side chains and the local backbone. (1999) (188)
- Computational method to reduce the search space for directed protein evolution (2001) (187)
- Guanidinium chloride induction of partial unfolding in amide proton exchange in RNase A. (1993) (171)
- Contribution of surface salt bridges to protein stability. (2000) (157)
- Pairwise calculation of protein solvent-accessible surface areas. (1998) (153)
- De novo protein design: towards fully automated sequence selection. (1997) (150)
- Blue fluorescent proteins with enhanced brightness and photostability from a structurally targeted library (2006) (148)
- Computational design of an integrin I domain stabilized in the open high affinity conformation (2000) (147)
- Particulate methane monooxygenase contains only mononuclear copper centers (2019) (146)
- Library analysis of SCHEMA‐guided protein recombination (2003) (144)
- Exact rotamer optimization for protein design (2003) (138)
- De novo design of biocatalysts. (2002) (135)
- Computational protein design. (1999) (128)
- Ca2+/calmodulin-dependent protein kinase II (CaMKII) is activated by calmodulin with two bound calciums (2006) (125)
- Modulating calmodulin binding specificity through computational protein design. (2002) (121)
- Exploring the origins of binding specificity through the computational redesign of calmodulin (2003) (121)
- Electrostatics in computational protein design. (2005) (120)
- Conformational splitting: A more powerful criterion for dead‐end elimination (2000) (119)
- A designed phenylalanyl-tRNA synthetase variant allows efficient in vivo incorporation of aryl ketone functionality into proteins. (2002) (117)
- Branch-and-terminate: a combinatorial optimization algorithm for protein design. (1999) (114)
- Coupling backbone flexibility and amino acid sequence selection in protein design (1997) (109)
- Combinatorial methods for small-molecule placement in computational enzyme design (2006) (109)
- A General Tool for Engineering the NAD/NADP Cofactor Preference of Oxidoreductases. (2017) (105)
- Distance dependence of photoinduced long-range electron transfer in zinc/ruthenium-modified myoglobins (1988) (103)
- Computationally designed libraries of fluorescent proteins evaluated by preservation and diversity of function (2007) (101)
- A de novo designed protein–protein interface (2007) (100)
- Generation of longer emission wavelength red fluorescent proteins using computationally designed libraries (2010) (98)
- A multi-substrate single-file model for ion-coupled transporters. (1996) (94)
- Achieving stability and conformational specificity in designed proteins via binary patterning. (2001) (83)
- Comparison of random mutagenesis and semi-rational designed libraries for improved cytochrome P450 BM3-catalyzed hydroxylation of small alkanes. (2012) (81)
- Protein stability engineering insights revealed by domain-wide comprehensive mutagenesis (2018) (78)
- Conformational splitting: A more powerful criterion for dead-end elimination (2000) (78)
- Electrostatics significantly affect the stability of designed homeodomain variants. (2002) (76)
- Engineering Transcriptional Regulator Effector Specificity Using Computational Design and In Vitro Rapid Prototyping: Developing a Vanillin Sensor. (2016) (75)
- Dramatic performance enhancements for the FASTER optimization algorithm (2006) (72)
- Experimental library screening demonstrates the successful application of computational protein design to large structural ensembles (2010) (70)
- De novo backbone and sequence design of an idealized α/β-barrel protein: evidence of stable tertiary structure (2003) (69)
- Full-sequence computational design and solution structure of a thermostable protein variant. (2007) (68)
- Impact of remote mutations on metallo‐β‐lactamase substrate specificity: Implications for the evolution of antibiotic resistance (2005) (65)
- Computational design of co-assembling protein–DNA nanowires (2015) (64)
- Radical performance enhancements for combinatorial optimization algorithms based on the dead-end elimination theorem (1998) (60)
- Repacking the Core of T4 lysozyme by automated design. (2003) (57)
- One‐ and two‐body decomposable Poisson‐Boltzmann methods for protein design calculations (2005) (54)
- An efficient algorithm for multistate protein design based on FASTER (2009) (54)
- A structural study of Hypocrea jecorina Cel5A (2011) (52)
- Designing proteins for therapeutic applications. (2003) (49)
- Prudent modeling of core polar residues in computational protein design. (2003) (48)
- Cell‐free protein synthesis enables high yielding synthesis of an active multicopper oxidase (2016) (46)
- Protein hydrogen exchange in denaturant: quantitative analysis by a two-process model. (1994) (45)
- Computationally focusing the directed evolution of proteins (2001) (44)
- Polar residues in the protein core of Escherichia coli thioredoxin are important for fold specificity. (2001) (44)
- Hydroxyl Groups in the ββ Sandwich of Metallo-β-lactamases Favor Enzyme Activity: A Computational Protein Design Study (2005) (43)
- Designed oligomers of cyanovirin-N show enhanced HIV neutralization (2011) (41)
- Adaptation of a fast Fourier transform‐based docking algorithm for protein design (2005) (41)
- NMR and temperature-jump measurements of de novo designed proteins demonstrate rapid folding in the absence of explicit selection for kinetics. (2003) (40)
- Designed protein G core variants fold to native‐like structures: Sequence selection by ORBIT tolerates variation in backbone specification (2001) (40)
- Radical performance enhancements for combinatorial optimization algorithms based on the dead‐end elimination theorem (1998) (39)
- Computationally designed variants of Escherichia coli chorismate mutase show altered catalytic activity. (2005) (39)
- Long-range electron transfer in structurally engineered pentaammineruthenium (histidine-62) cytochrome c (1989) (39)
- Computational protein design promises to revolutionize protein engineering. (2007) (38)
- Generation and analysis of proline mutants in protein G. (2006) (38)
- Circular dichroism determination of class I MHC‐peptide equilibrium dissociation constants (1997) (37)
- Direct visualization reveals dynamics of a transient intermediate during protein assembly (2011) (36)
- ProtaBank: A repository for protein design and engineering data (2018) (34)
- Kinetics and mechanisms of electron transfer between blue copper proteins and electronically excited chromium and ruthenium polypyridine complexes (1985) (33)
- Computational design and experimental verification of a symmetric protein homodimer (2015) (33)
- An improved pairwise decomposable finite‐difference Poisson–Boltzmann method for computational protein design (2008) (31)
- Rubredoxin Variant Folds without Iron (1999) (30)
- The beta-beta-alpha fold: explorations in sequence space. (2001) (29)
- De novo backbone and sequence design of an idealized alpha/beta-barrel protein: evidence of stable tertiary structure. (2003) (28)
- Structure of a protein G helix variant suggests the importance of helix propensity and helix dipole interactions in protein design (2000) (27)
- Exhaustive mutagenesis of six secondary active-site residues in Escherichia coli chorismate mutase shows the importance of hydrophobic side chains and a helix N-capping position for stability and catalysis. (2007) (27)
- Stereochemical studies on protonated bridgehead amines. ^1H NMR determination of cis and trans B-C ring-fused structures for salts of hexahydropyrrolo [2,1-a] isoquinolines and related C ring homologs. Capture of unstable ring-fused structures in the solid state (1989) (23)
- Establishing the entatic state in folding metallated Pseudomonas aeruginosa azurin (2007) (23)
- Designing protein β-sheet surfaces by Z-score optimization (2000) (21)
- Preprocessing of rotamers for protein design calculations (2004) (20)
- Recovery of Red Fluorescent Protein Chromophore Maturation Deficiency through Rational Design (2012) (20)
- Mechanism of an ATP-independent Protein Disaggregase (2013) (20)
- Evaluation of the energetic contribution of an ionic network to beta‐sheet stability (2002) (20)
- Evaluating and optimizing computational protein design force fields using fixed composition-based negative design (2008) (18)
- Nerve Agent Hydrolysis Activity Designed into a Human Drug Metabolism Enzyme (2011) (18)
- Simple electrostatic model improves designed protein sequences (2006) (18)
- Monomerization of far-red fluorescent proteins (2017) (17)
- Structural, kinetic, and thermodynamic studies of specificity designed HIV‐1 protease (2012) (17)
- Computational design and biochemical characterization of maize nonspecific lipid transfer protein variants for biosensor applications (2007) (16)
- Using Molecular Dynamics Simulations as an Aid in the Prediction of Domain Swapping of Computationally Designed Protein Variants. (2015) (14)
- A designed protein interface that blocks fibril formation. (2004) (12)
- Dioxane contributes to the altered conformation and oligomerization state of a designed engrailed homeodomain variant (2005) (11)
- Phenalene−phosphazene complexes: injection of electron spin density into the cyclotriphosphazene ring system (1985) (11)
- The ββα fold: explorations in sequence space11Edited by M. F. Summers (2001) (10)
- A search algorithm for fixed‐composition protein design (2006) (9)
- Site-specific modification of α-helical peptides with electron donors and acceptors (1996) (8)
- Microbiome for Mars: surveying microbiome connections to healthcare with implications for long-duration human spaceflight, virtual workshop, July 13, 2020 (2021) (8)
- Direct Amination of 9-Hydroxy-1-oxophenalene to Produce 9-Amino-1-oxophenalene and Related Compounds (1985) (8)
- GRID: A high‐resolution protein structure refinement algorithm (2013) (8)
- Computational Design of the β-Sheet Surface of a Red Fluorescent Protein Allows Control of Protein Oligomerization (2015) (8)
- Phenalene-phosphazene complexes: Effect of exocyclic charge densities on the cyclotriphosphazene ring system (1988) (8)
- bound calciums /calmodulin-dependent protein kinase II (CaMKII) is activated by calmodulin with two 2+ Ca (2006) (7)
- Engineering Transcriptional Regulator Effector Specificity using Computational Design and In Vitro Rapid Prototyping: Developing a Vanillin Sensor (2015) (7)
- The design of evolution and the evolution of design (2007) (7)
- 1,3,4,6‐Tetramethyl‐1,4‐dihydro‐1,2,4,5‐tetrazine, C6H12N4 (1984) (6)
- NMR-detected conformational exchange observed in a computationally designed variant of protein Gbeta1. (2008) (6)
- Hydroxyl groups in the (beta)beta sandwich of metallo-beta-lactamases favor enzyme activity: a computational protein design study. (2005) (5)
- ProtaBank: A repository for protein design and engineering data (2019) (5)
- The bba Fold: Explorations in Sequence Space (2001) (4)
- Designing protein beta-sheet surfaces by Z-score optimization. (2000) (4)
- In Silico Screening of Computational Enzyme Designs (2012) (3)
- Genome manipulation by guide-directed Argonaute cleavage (2022) (3)
- Long-Range Electron Transfer in Ruthenium-Modified Proteins (1988) (2)
- Phenalene - Phosphazene Complexes: Injection of Electron Spin Density Into the Cyclotriphosphazene Ring System. (1986) (2)
- The structure of a far‐red fluorescent protein, AQ143, shows evidence in support of reported red‐shifting chromophore interactions (2014) (2)
- Attempts to develop an enzyme converting DHIV to KIV. (2019) (2)
- A designed apoplastocyanin variant that shows reversible folding. (2002) (1)
- Editorial overview: Computational protein design (2002) (1)
- Stereochemical studies on protonated bridgehead amines. Proton NMR determination of cis and trans B-C ring-fused structures for salts of hexahydropyrrolo[2,1-a]isoquinolines and related C ring homologs. Capture of unstable ring-fused structures in the solid state [Erratum to document cited in CA110( (1989) (1)
- Guide-directed DNA cleavage by a prokaryotic Argonaute protein induces chromosome recombination in Escherichia coli (2021) (1)
- Electron transfer in structurally engineered metalloproteins (1988) (1)
- Biological methane oxidation is catalyzed by a mononuclear copper center in particulate methane monooxygenase (2019) (0)
- The structure of HcRed7, a brighter and red-shifted HcRed variant (2018) (0)
- PEBank: A Comprehensive Database for Protein Engineering and Design (2018) (0)
- RUBREDOXIN VARIANT (PFRD-XC4) FOLDS WITHOUT IRON (2000) (0)
- Electron-transfer studies on a ruthenated [histidine-62] cytochrome c mutant (1989) (0)
- Crystal Structure of Kemp Elimination Catalyst 1A53-2 (2011) (0)
- For the Record (1973) (0)
- DELTA1.5: A COMPUTATIONALLY DESIGNED CORE VARIANT OF THE B1 DOMAIN OF STREPTOCOCCAL PROTEIN G (2001) (0)
- T4 LYSOZYME CORE REPACKING MUTANT A111V/CORE10/TA (2003) (0)
- Engineering and design computational protein design - Editorial overview (2002) (0)
- Interactive computational and experimental approaches improve the sensitivity of periplasmic binding protein-based nicotine biosensors for measurements in biofluids (2023) (0)
- Crystal Structure of Kemp Eliminase HG3.17 E47N,N300D Complexed with Transition State Analog 6-Nitrobenzotriazole (2013) (0)
- CORE REDESIGN BACK-REVERTANT I103V/CORE10 (2003) (0)
- Replica Exchange Monte Carlo GRID: A novel high-resolution refinement algorithm (2012) (0)
- T4 LYSOZYME CORE REPACKING MUTANT CORE10/TA (2003) (0)
- Phenalene-Phosphazene Complexes: Effect of Exocyclic Charge Densities on the Cyclotriphosphazene Ring System. (1988) (0)
- The discobody: an engineered discoidin domain from factor VIII that binds v 3 integrin with antibody-like affinities (2015) (0)
- Multi-State Computational Design and Experimental Characterization of Triosephosphate Isomerase Flexible Hinges (2012) (0)
- Development and Validation of Methods for Multi-State Design and Combinatorial Library Design (2009) (0)
- HELIX VARIANT OF THE B1 DOMAIN FROM STREPTOCOCCAL PROTEIN G (2002) (0)
- Computational Thermostable Cellulase Engineering for Enhanced Biofuel Production (2012) (0)
- HYPERTHERMOPHILIC VARIANT OF THE B1 DOMAIN FROM STREPTOCOCCAL PROTEIN G, NMR, 47 STRUCTURES (1998) (0)
- An apparatus and method for the automated design of proteins (1998) (0)
- T4 Lysozyme Core Repacking Mutant L118I/TA (2003) (0)
- FULL SEQUENCE DESIGN 1 (FSD-1) OF BETA BETA ALPHA MOTIF, NMR, MINIMIZED AVERAGE STRUCTURE (1998) (0)
- T4 LYSOZYME CORE REPACKING BACK-REVERTANT L102M/CORE10 (2003) (0)
- Crystal Structure an Tandem Cyanovirin-N Dimer, CVN2L10 (2011) (0)
- Crystal Structure of Kemp Eliminase HG-2 Complexed with Transition State Analog 5-Nitro Benzotriazole (2011) (0)
- Stereochemical Studies on Protonated Bridgehead Amines. 1H NMR Determination of cis and trans B‐C Ring‐Fused Structures for Salts of Hexahydropyrrolo(2,1‐a)isoquinolines and Related C Ring Homologues. Capture of Unstable Ring‐Fused Structures in the Solid State (1989) (0)
- Optimization Strategies for the Design of Protein Sequences and Combinatorial Mutation Libraries (2009) (0)
- Engineering Transcriptional Regulator Effector Specificity Through Rational Design and Rapid Prototyping (2014) (0)
- Using molecular dynamics simulations to predict domain swapping of computationally designed protein variants (2015) (0)
- Bridging the divide: A tale of the merger of computational chemistry and structural biology in enzyme design (2015) (0)
- Solution structure of a computational designed dimer based on the engrailed homeodomain structure (2015) (0)
- COMPUTATIONALLY DESIGNED PEPTIDE WITH A BETA-BETA-ALPHA FOLD SELECTION, NMR, 32 STRUCTURES (1998) (0)
- Duplicate Publication (1998) (0)
- Crystal Structure of Cel5A (EG2) from Hypocrea jecorina (Trichoderma reesei) (2011) (0)
- Crystal Structure of Kemp Elimination Catalyst 1A53-2 Complexed with Transition State Analog 5-Nitro Benzotriazole (2011) (0)
- Designing Conformational Control of Human Tissue Transglutaminase for Applications in Huntington's Disease Research (2012) (0)
- Crystal Structure of a computational designed engrailed homeodomain variant fused with YFP (2014) (0)
- SOLUTION STRUCTURE OF FSD-EY, A NOVEL PEPTIDE ASSUMING A BETA-BETA-ALPHA FOLD (2001) (0)
- FULL SEQUENCE DESIGN 1 (FSD-1) OF BETA BETA ALPHA MOTIF, NMR, 41 STRUCTURES (1997) (0)
- T4 Lysozyme Core Repacking Mutant V149I/T152V/TA (2003) (0)
- Correction: Nerve Agent Hydrolysis Activity Designed into a Human Drug Metabolism Enzyme (2012) (0)
- FULL SEQUENCE DESIGN 1 OF BETA BETA ALPHA MOTIF, DESIGN ALGORITHM PREDICTION, THEORETICAL MODEL (1998) (0)
- Computational Model Optimization for Enzyme Design Applications (2004) (0)
- Engineering Monomerization of Red Fluorescent Proteins Through Computational Design (2012) (0)
- Conception evolutive a ciblage informatique (2002) (0)
- Computationally-guided directed evolution (2000) (0)
- T4 LYOSZYME CORE REPACKING MUTANT I100V/TA (2003) (0)
- Crystal Structure of an Inactive Kemp Elimination Design HG-1 (2011) (0)
- T4 LYSOZYME CORE REPACKING MUTANT I118L/CORE7/TA (2003) (0)
This paper list is powered by the following services:
Other Resources About Stephen L. Mayo
What Schools Are Affiliated With Stephen L. Mayo?
Stephen L. Mayo is affiliated with the following schools:
