Stephen M. Beverley
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Biology
Stephen M. Beverley's Degrees
- PhD Molecular Biology University of California, San Francisco
- Bachelors Biology University of California, Berkeley
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(Suggest an Edit or Addition)Stephen M. Beverley's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The Genome of the Kinetoplastid Parasite, Leishmania major (2005) (1355)
- Rapid duplication and loss of genes coding for the alpha chains of hemoglobin. (1980) (516)
- Stable transfection of the human parasite Leishmania major delineates a 30-kilobase region sufficient for extrachromosomal replication and expression (1990) (387)
- Central memory T cells mediate long-term immunity to Leishmania major in the absence of persistent parasites (2004) (378)
- Molecular Evolution in Drosophila and the Higher Diptera II. A Time Scale for Fly Evolution (1984) (365)
- A lipophosphoglycan-independent method for isolation of infective Leishmania metacyclic promastigotes by density gradient centrifugation. (2001) (351)
- Coupling of poly(A) site selection and trans-splicing in Leishmania. (1993) (336)
- Leishmania RNA Virus Controls the Severity of Mucocutaneous Leishmaniasis (2011) (335)
- Lipophosphoglycan is a virulence factor distinct from related glycoconjugates in the protozoan parasite Leishmania major. (2000) (324)
- Double targeted gene replacement for creating null mutants. (1991) (312)
- Demonstration of Genetic Exchange During Cyclical Development of Leishmania in the Sand Fly Vector (2009) (303)
- The role(s) of lipophosphoglycan (LPG) in the establishment of Leishmania major infections in mammalian hosts (2003) (278)
- PLOS Neglected Tropical Diseases (2014) (277)
- Improvements in transfection efficiency and tests of RNA interference (RNAi) approaches in the protozoan parasite Leishmania. (2003) (274)
- Use of the green fluorescent protein as a marker in transfected Leishmania. (1996) (255)
- Intergenic region typing (IRT): a rapid molecular approach to the characterization and evolution of Leishmania. (1995) (248)
- Evolution of nuclear ribosomal RNAs in kinetoplastid protozoa: perspectives on the age and origins of parasitism. (1993) (244)
- Migratory Dermal Dendritic Cells Act as Rapid Sensors of Protozoan Parasites (2008) (239)
- Gene amplification in Leishmania. (1991) (236)
- Development of a safe live Leishmania vaccine line by gene replacement. (1995) (231)
- Gene replacement in parasitic protozoa (1990) (215)
- The role of phosphoglycans in Leishmania-sand fly interactions. (2000) (211)
- Retention and Loss of RNA Interference Pathways in Trypanosomatid Protozoans (2010) (211)
- Evidence that the vectorial competence of phlebotomine sand flies for different species of Leishmania is controlled by structural polymorphisms in the surface lipophosphoglycan. (1994) (206)
- Unstable DNA amplifications in methotrexate resistant Leishmania consist of extrachromosomal circles which relocalize during stabilization (1984) (202)
- Plasticity in chromosome number and testing of essential genes in Leishmania by targeting. (1993) (202)
- Development of a stable Leishmania expression vector and application to the study of parasite surface antigen genes. (1990) (201)
- Overproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica. (1983) (196)
- Heavy metal resistance: a new role for P-glycoproteins in Leishmania. (1991) (189)
- Properties of an altered dihydrofolate reductase encoded by amplified genes in cultured mouse fibroblasts. (1981) (187)
- Is lipophosphoglycan a virulence factor? A surprising diversity between Leishmania species. (2001) (186)
- An in vitro system for developmental and genetic studies of Leishmania donovani phosphoglycans. (2003) (181)
- Persistence Without Pathology in Phosphoglycan-Deficient Leishmania major (2003) (181)
- Lipophosphoglycan (LPG) and the identification of virulence genes in the protozoan parasite Leishmania. (1998) (174)
- The Roles of Pteridine Reductase 1 and Dihydrofolate Reductase-Thymidylate Synthase in Pteridine Metabolism in the Protozoan Parasite Leishmania major* (1997) (168)
- A specialized pathway affecting virulence glycoconjugates of Leishmania. (1995) (164)
- PTR1: a reductase mediating salvage of oxidized pteridines and methotrexate resistance in the protozoan parasite Leishmania major. (1994) (163)
- Characterization of the 'unusual' mobility of large circular DNAs in pulsed field-gradient electrophoresis. (1988) (160)
- Non-pathogenic trypanosomatid protozoa as a platform for protein research and production. (2002) (156)
- Trans-kingdom transposition of the Drosophila element mariner within the protozoan Leishmania. (1997) (154)
- Golgi GDP-mannose Uptake Requires Leishmania LPG2 (1997) (149)
- Vaccination with Phosphoglycan-Deficient Leishmania major Protects Highly Susceptible Mice from Virulent Challenge without Inducing a Strong Th1 Response1 (2004) (140)
- Regulation of Differentiation to the Infective Stage of the Protozoan Parasite Leishmania major by Tetrahydrobiopterin (2001) (136)
- Protozomics: trypanosomatid parasite genetics comes of age (2003) (134)
- Phosphoproteome dynamics reveal heat-shock protein complexes specific to the Leishmania donovani infectious stage (2010) (132)
- Demonstration of circularization of herpes simplex virus DNA following infection using pulsed field gel electrophoresis. (1993) (130)
- Characterization of a Defensin from the Sand Fly Phlebotomus duboscqi Induced by Challenge with Bacteria or the Protozoan Parasite Leishmania major (2004) (130)
- Expression profiling using random genomic DNA microarrays identifies differentially expressed genes associated with three major developmental stages of the protozoan parasite Leishmania major. (2004) (127)
- A set of independent selectable markers for transfection of the human malaria parasite Plasmodium falciparum. (1999) (127)
- Transfection of Leishmania and Trypanosoma brucei by electroporation. (1993) (126)
- Primary structure of the gene encoding the bifunctional dihydrofolate reductase-thymidylate synthase of Leishmania major. (1986) (126)
- Cloning of Leishmania nucleoside transporter genes by rescue of a transport-deficient mutant. (1998) (125)
- Functional genetic identification of PRP1, an ABC transporter superfamily member conferring pentamidine resistance in Leishmania major. (2003) (124)
- A bifunctional thymidylate synthetase-dihydrofolate reductase in protozoa. (1984) (123)
- Eukaryotic UDP-Galactopyranose Mutase (GLF Gene) in Microbial and Metazoal Pathogens (2005) (120)
- Leishmania major: promastigotes induce expression of a subset of chemokine genes in murine macrophages. (1997) (120)
- Sphingolipids are essential for differentiation but not growth in Leishmania (2003) (118)
- cis and trans factors affecting Mos1 mariner evolution and transposition in vitro, and its potential for functional genomics. (2000) (118)
- Isolation of virulence genes directing surface glycosyl-phosphatidylinositol synthesis by functional complementation of Leishmania. (1993) (116)
- Redirection of sphingolipid metabolism toward de novo synthesis of ethanolamine in Leishmania (2007) (114)
- Discrimination Amongst Leishmania by Polymerase Chain Reaction and Hybridization with Small Subunit Ribosomal DNA Derived Oligonucleotides (1994) (113)
- Dual role of the fringe connection gene in both heparan sulphate and fringe-dependent signalling events (2001) (112)
- Phospholipid and sphingolipid metabolism in Leishmania. (2010) (110)
- New approaches to Leishmania chemotherapy: pteridine reductase 1 (PTR1) as a target and modulator of antifolate sensitivity (1997) (109)
- Ether Phospholipids and Glycosylinositolphospholipids Are Not Required for Amastigote Virulence or for Inhibition of Macrophage Activation by Leishmania major* (2003) (109)
- A lipophosphoglycan-independent development of Leishmania in permissive sand flies. (2007) (108)
- Pteridine reductase mechanism correlates pterin metabolism with drug resistance in trypanosomatid parasites (2001) (107)
- Relationship of amplified dihydrofolate reductase genes to double minute chromosomes in unstably resistant mouse fibroblast cell lines (1981) (102)
- Leishmania salvage and remodelling of host sphingolipids in amastigote survival and acidocalcisome biogenesis (2005) (102)
- Multiple drug resistance and conservative amplification of the H region in Leishmania major. (1989) (99)
- Association of the Endobiont Double-Stranded RNA Virus LRV1 With Treatment Failure for Human Leishmaniasis Caused by Leishmania braziliensis in Peru and Bolivia. (2016) (98)
- Evolution of the genus Leishmania as revealed by comparisons of nuclear DNA restriction fragment patterns. (1987) (96)
- Pteridine salvage throughout the Leishmania infectious cycle: implications for antifolate chemotherapy. (2001) (94)
- Rapid spontaneous dihydrofolate reductase gene amplification shown by fluorescence-activated cell sorting. (1983) (93)
- Folate metabolic pathways in Leishmania. (2011) (92)
- Genetic nomenclature for Trypanosoma and Leishmania. (1998) (91)
- The Leishmania GDP-mannose transporter is an autonomous, multi-specific, hexameric complex of LPG2 subunits. (2000) (91)
- A member of the aldoketo reductase family confers methotrexate resistance in Leishmania. (1992) (91)
- Shuttle cosmid vectors for the trypanosomatid parasite Leishmania. (1993) (90)
- Transposon Mutagenesis of Mycobacterium marinum Identifies a Locus Linking Pigmentation and Intracellular Survival (2003) (90)
- The Mating Competence of Geographically Diverse Leishmania major Strains in Their Natural and Unnatural Sand Fly Vectors (2013) (89)
- Structural alterations of chromosome 2 in Leishmania major as evidence for diploidy, including spontaneous amplification of the mini-exon array. (1989) (89)
- Leishmania RNA virus: when the host pays the toll (2012) (88)
- Continual renewal and replication of persistent Leishmania major parasites in concomitantly immune hosts (2017) (86)
- Gene Expression in Leishmania Is Regulated Predominantly by Gene Dosage (2017) (85)
- Developmentally regulated sphingolipid synthesis in African trypanosomes (2008) (83)
- Biochemical and Genetic Tests for Inhibitors ofLeishmaniaPteridine Pathways (1997) (83)
- Leishmania amazonensis Arginase Compartmentalization in the Glycosome Is Important for Parasite Infectivity (2012) (82)
- Leishmania major lacking arginase (ARG) are auxotrophic for polyamines but retain infectivity to susceptible BALB/c mice. (2009) (82)
- Expansion of the target of rapamycin (TOR) kinase family and function in Leishmania shows that TOR3 is required for acidocalcisome biogenesis and animal infectivity (2010) (79)
- Selection against the dihydrofolate reductase-thymidylate synthase (DHFR-TS) locus as a probe of genetic alterations in Leishmania major (1996) (79)
- Leishmania LPG3 encodes a GRP94 homolog required for phosphoglycan synthesis implicated in parasite virulence but not viability (2002) (79)
- Detection of Leishmania RNA Virus in Leishmania Parasites (2013) (78)
- The Susceptibility of Trypanosomatid Pathogens to PI3/mTOR Kinase Inhibitors Affords a New Opportunity for Drug Repurposing (2011) (78)
- A role for tetrahydrofolates in the metabolism of iron-sulfur clusters in all domains of life (2010) (77)
- Regulated expression of the Leishmania major surface virulence factor lipophosphoglycan using conditionally destabilized fusion proteins (2009) (74)
- Leishmania aethiopica Field Isolates Bearing an Endosymbiontic dsRNA Virus Induce Pro-inflammatory Cytokine Response (2014) (73)
- Study of the safety, immunogenicity and efficacy of attenuated and killed Leishmania (Leishmania) major vaccines in a rhesus monkey (Macaca mulatta) model of the human disease. (2002) (72)
- Type I interferons induced by endogenous or exogenous viral infections promote metastasis and relapse of leishmaniasis (2017) (71)
- The immunological, environmental, and phylogenetic perpetrators of metastatic leishmaniasis. (2014) (71)
- Cross-species genetic exchange between visceral and cutaneous strains of Leishmania in the sand fly vector (2014) (71)
- In vivo imaging of transgenic Leishmania parasites in a live host. (2010) (70)
- Leishmania Lipophosphoglycan Triggers Caspase-11 and the Non-canonical Activation of the NLRP3 Inflammasome (2019) (70)
- Two more independent selectable markers for stable transfection of Leishmania. (1993) (69)
- The Leishmania donovani LD1 locus gene ORFG encodes a biopterin transporter (BT1). (1999) (68)
- Identification of a Compensatory Mutant (lpg2−REV) of Leishmania major Able To Survive as Amastigotes within Macrophages without LPG2-Dependent Glycoconjugates and Its Significance to Virulence and Immunization Strategies (2004) (68)
- Infection with Arginase-Deficient Leishmania major Reveals a Parasite Number-Dependent and Cytokine-Independent Regulation of Host Cellular Arginase Activity and Disease Pathogenesis1 (2009) (67)
- Stable DNA transfection of a wide range of trypanosomatids. (1991) (67)
- Biochemistry and regulation of folate and methotrexate transport in Leishmania major. (1987) (66)
- Degradation of Host Sphingomyelin Is Essential for Leishmania Virulence (2009) (65)
- Characterization of inositol phosphorylceramides from Leishmania major by tandem mass spectrometry with electrospray ionization (2007) (65)
- Structures of Leishmania major pteridine reductase complexes reveal the active site features important for ligand binding and to guide inhibitor design. (2005) (64)
- Genomewide insertional mutagenesis in Streptomyces coelicolor reveals additional genes involved in morphological differentiation. (2000) (64)
- Leishmania major Glycosylation Mutants Require Phosphoglycans (lpg2 −) but Not Lipophosphoglycan (lpg1 −) for Survival in Permissive Sand Fly Vectors (2010) (63)
- Reductions in methotrexate and folate influx in methotrexate-resistant lines of Leishmania major are independent of R or H region amplification. (1987) (63)
- Viral discovery and diversity in trypanosomatid protozoa with a focus on relatives of the human parasite Leishmania (2017) (63)
- Two Functionally Divergent UDP-Gal Nucleotide Sugar Transporters Participate in Phosphoglycan Synthesis in Leishmania major* (2007) (61)
- Differential Induction of TLR3-Dependent Innate Immune Signaling by Closely Related Parasite Species (2014) (61)
- Leishmania donovani lacking the Golgi GDP-Man transporter LPG2 exhibit attenuated virulence in mammalian hosts. (2009) (61)
- Novel DNA rearrangements are associated with dihydrofolate reductase gene amplification. (1984) (61)
- Differential Microbicidal Effects of Human Histone Proteins H2A and H2B on Leishmania Promastigotes and Amastigotes (2010) (60)
- A dhfr-ts- Leishmania major knockout mutant cross-protects against Leishmania amazonensis. (1999) (60)
- Leishmania tarentolae taxonomic relatedness inferred from phylogenetic analysis of the small subunit ribosomal RNA gene. (1992) (58)
- Isolation of Genes Mediating Resistance to Inhibitors of Nucleoside and Ergosterol Metabolism in Leishmania by Overexpression/Selection* (1999) (58)
- Proteophosphoglycan confers resistance of Leishmania major to midgut digestive enzymes induced by blood feeding in vector sand flies (2010) (58)
- Whole genome sequencing of experimental hybrids supports meiosis-like sexual recombination in Leishmania (2019) (57)
- Comparisons of Mutants Lacking the Golgi UDP-Galactose or GDP-Mannose Transporters Establish that Phosphoglycans Are Important for Promastigote but Not Amastigote Virulence in Leishmania major (2007) (57)
- Molecular evolution of Drosophila and higher Diptera. I. Micro-complement fixation studies of a larval hemolymph protein. (1982) (56)
- Immunomodulatory and Antileishmanial Activity of Phenylpropanoid Dimers Isolated from Nectandra leucantha. (2015) (55)
- Ancient origin for Hawaiian Drosophilinae inferred from protein comparisons. (1985) (55)
- Evolution and expression of the Leishmania surface proteinase (gp63) gene locus. (1993) (54)
- Leishmania major Survival in Selective Phlebotomus papatasi Sand Fly Vector Requires a Specific SCG-Encoded Lipophosphoglycan Galactosylation Pattern (2010) (53)
- Loss of the GP46/M-2 surface membrane glycoprotein gene family in the Leishmania braziliensis complex. (1992) (52)
- Methylene tetrahydrofolate dehydrogenase/cyclohydrolase and the synthesis of 10‐CHO‐THF are essential in Leishmania major (2009) (51)
- Leishmaniavirus-Dependent Metastatic Leishmaniasis Is Prevented by Blocking IL-17A (2016) (51)
- Simultaneous transient expression assays of the trypanosomatid parasite Leishmania using β-galactosidase and β-glucuronidase as reporter enzymes (1991) (51)
- Mammalian Innate Immune Response to a Leishmania-Resident RNA Virus Increases Macrophage Survival to Promote Parasite Persistence. (2016) (50)
- In vitro activity of sulfonamides and sulfones against Leishmania major promastigotes (1987) (50)
- Protective Immunity Against the Protozoan Leishmania chagasi Is Induced by Subclinical Cutaneous Infection with Virulent But Not Avirulent Organisms1 (2001) (50)
- Atypical Manifestations of Cutaneous Leishmaniasis in a Region Endemic for Leishmania braziliensis: Clinical, Immunological and Parasitological Aspects (2016) (50)
- Recurrent de novo appearance of small linear DNAs in Leishmania major and relationship to extra-chromosomal DNAs in other species. (1990) (49)
- The application of gene expression microarray technology to kinetoplastid research. (2004) (49)
- Comparative genomic analysis of Leishmania (Viannia) peruviana and Leishmania (Viannia) braziliensis (2015) (48)
- Innate Immune Activation and Subversion of Mammalian Functions by Leishmania Lipophosphoglycan (2012) (48)
- Functional identification of a Leishmania gene related to the peroxin 2 gene reveals common ancestry of glycosomes and peroxisomes (1997) (47)
- Amplified DNAs in laboratory stocks of Leishmania tarentolae: extrachromosomal circles structurally and functionally similar to the inverted-H-region amplification of methotrexate-resistant Leishmania major. (1988) (46)
- Muco-cutaneous leishmaniasis in the New World (2011) (46)
- Transcriptional mapping of the amplified region encoding the dihydrofolate reductase-thymidylate synthase of Leishmania major reveals a high density of transcripts, including overlapping and antisense RNAs (1989) (46)
- A survey of the Leishmania major Friedlin strain V1 genome by shotgun sequencing: a resource for DNA microarrays and expression profiling. (2001) (46)
- The Leishmania genome project: new insights into gene organization and function (2001) (46)
- Inoculation of killed Leishmania major into immune mice rapidly disrupts immunity to a secondary challenge via IL-10-mediated process (2009) (45)
- The LPG1 gene family of Leishmania major. (2004) (45)
- Leishmania major Phosphoglycans Influence the Host Early Immune Response by Modulating Dendritic Cell Functions (2009) (45)
- Designing glycoconjugate biosynthesis for an insidious intent: phosphoglycan assembly in Leishmania parasites. (1997) (43)
- Heterologous Expression of Trypanosoma cruzi trans-Sialidase in Leishmania major Enhances Virulence (2000) (43)
- Functional Identification of Galactosyltransferases (SCGs) Required for Species-specific Modifications of the Lipophosphoglycan Adhesin Controlling Leishmania major-Sand Fly Interactions* (2003) (42)
- The PGPA gene of Leishmania major mediates antimony (SbIII) resistance by decreasing influx and not by increasing efflux. (1994) (42)
- Stage-specific activity of the Leishmania major CRK3 kinase and functional rescue of a Schizosaccharomyces pombe cdc2 mutant. (1998) (42)
- Identification of Genes Encoding Arabinosyltransferases (SCA) Mediating Developmental Modifications of Lipophosphoglycan Required for Sand Fly Transmission of Leishmania major* (2003) (42)
- An alternative in vitro drug screening test using Leishmania amazonensis transfected with red fluorescent protein. (2013) (41)
- Nuclease mapping and DNA sequence analysis of transcripts from the dihydrofolate reductase-thymidylate synthase (R) region of Leishmania major. (1990) (41)
- Parasite-Derived Arginase Influences Secondary Anti-Leishmania Immunity by Regulating Programmed Cell Death-1–Mediated CD4+ T Cell Exhaustion (2013) (40)
- Tilting the balance between RNA interference and replication eradicates Leishmania RNA virus 1 and mitigates the inflammatory response (2016) (40)
- Phylogenomic and Functional Analysis of Pterin-4a-Carbinolamine Dehydratase Family (COG2154) Proteins in Plants and Microorganisms1[W][OA] (2008) (40)
- Hijacking the Cell: Parasites in the Driver's Seat (1996) (38)
- Therapeutic Efficacy of Stable Analogues of Vasoactive Intestinal Peptide against Pathogens* (2014) (38)
- Killed but Metabolically Active Leishmania infantum as a Novel Whole-Cell Vaccine for Visceral Leishmaniasis (2012) (37)
- The Role of the Mitochondrial Glycine Cleavage Complex in the Metabolism and Virulence of the Protozoan Parasite Leishmania major* (2008) (36)
- A test for genetic exchange in mixed infections of Leishmania major in the sand fly Phlebotomus papatasi. (1991) (36)
- Sphingolipids in parasitic protozoa. (2010) (36)
- Reconstitution of GDP-mannose Transport Activity with Purified Leishmania LPG2 Protein in Liposomes* (2005) (35)
- A Novel Role for Stat1 in Phagosome Acidification and Natural Host Resistance to Intracellular Infection by Leishmania major (2009) (35)
- Blasticidin resistance: a new independent marker for stable transfection of Leishmania. (2000) (35)
- PTR1-dependent synthesis of tetrahydrobiopterin contributes to oxidant susceptibility in the trypanosomatid protozoan parasite Leishmania major (2009) (33)
- Epitope cleavage by Leishmania endopeptidase(s) limits the efficiency of the exogenous pathway of major histocompatibility complex class I‐associated antigen presentation (1997) (33)
- Purified mariner (Mos1) transposase catalyzes the integration of marked elements into the germ-line of the yellow fever mosquito, Aedes aegypti. (2000) (32)
- Estimation of circular DNA size using γ-irradiation and pulsed-field gel electrophoresis (1989) (32)
- Characterization of quinonoid-Dihydropteridine Reductase (QDPR) from the Lower Eukaryote Leishmania major * (2002) (32)
- Leishmania major pteridine reductase 1 belongs to the short chain dehydrogenase family: stereochemical and kinetic evidence. (1998) (32)
- Immunization with Persistent Attenuated Δlpg2 Leishmania major Parasites Requires Adjuvant To Provide Protective Immunity in C57BL/6 Mice (2006) (31)
- Unusual Galactofuranose Modification of a Capsule Polysaccharide in the Pathogenic Yeast Cryptococcus neoformans * (2013) (31)
- Leishmania mexicana promastigotes induce cytotoxic T lymphocytes in vivo that do not recognize infected macrophages (1993) (31)
- Antiviral screening identifies adenosine analogs targeting the endogenous dsRNA Leishmania RNA virus 1 (LRV1) pathogenicity factor (2017) (30)
- Thymidine kinase as a negative selectable marker in Leishmania major. (1992) (30)
- Putting the Leishmania genome to work: functional genomics by transposon trapping and expression profiling. (2002) (30)
- Kinetoplastid-specific histone variant functions are conserved in Leishmania major. (2013) (30)
- The structure and repertoire of small interfering RNAs in Leishmania (Viannia) braziliensis reveal diversification in the trypanosomatid RNAi pathway (2013) (30)
- Leishmanicidal activity of two naphthoquinones against Leishmania donovani. (2012) (29)
- Unstable amplification of two extrachromosomal elements in alpha-difluoromethylornithine-resistant Leishmania donovani (1992) (29)
- Exacerbated Leishmaniasis Caused by a Viral Endosymbiont can be Prevented by Immunization with Its Viral Capsid (2017) (28)
- Stable amplification of a linear extrachromosomal DNA in mycophenolic acid-resistant Leishmania donovani. (1992) (27)
- Genomic organization and expression of the expanded SCG/L/R gene family of Leishmania major: internal clusters and telomeric localization of SCGs mediating species-specific LPG modifications. (2006) (26)
- Wild-type and drug-resistant Leishmania major hydrolyze methotrexate to N-10-methyl-4-deoxy-4-aminopteroate without accumulation of methotrexate polyglutamates. (1989) (26)
- Leishmania guyanensis parasites block the activation of the inflammasome by inhibiting maturation of IL-1β (2018) (26)
- A Narnavirus-Like Element from the Trypanosomatid Protozoan Parasite Leptomonas seymouri (2016) (26)
- Insertional mutagenesis by a modified in vitro Ty1 transposition system. (1997) (26)
- Biochemical and Genetic Analysis of Methylenetetrahydrofolate Reductase in Leishmania Metabolism and Virulence* (2006) (25)
- Biochemical and genetic tests for inhibitors of Leishmania pteridine pathways. (1997) (25)
- A Molecular Docking Strategy Identifies Eosin B as a Non-active Site Inhibitor of Protozoal Bifunctional Thymidylate Synthase-Dihydrofolate Reductase* (2003) (24)
- Antigens targeted to the Leishmania phagolysosome are processed for CD4+ T cell recognition (1993) (24)
- Amplification of an alternate transporter gene suppresses the avirulent phenotype of glucose transporter null mutants in Leishmania mexicana (2009) (24)
- A Novel Bunyavirus-Like Virus of Trypanosomatid Protist Parasites (2016) (23)
- Identification of Transport-critical Residues in a Folate Transporter from the Folate-Biopterin Transporter (FBT) Family* (2009) (23)
- Multiple-stage linear ion-trap with high resolution mass spectrometry towards complete structural characterization of phosphatidylethanolamines containing cyclopropane fatty acyl chain in Leishmania infantum. (2014) (23)
- Sequence and S1 nuclease mapping of the 5' region of the dihydrofolate reductase-thymidylate synthase gene of Leishmania major. (1987) (23)
- Uncovering Leishmania-macrophage interplay using imaging flow cytometry. (2015) (22)
- A transposon toolkit for gene transfer and mutagenesis in protozoan parasites (2010) (22)
- Deletion of UDP-glucose pyrophosphorylase reveals a UDP-glucose independent UDP-galactose salvage pathway in Leishmania major. (2010) (22)
- Severe Cutaneous Leishmaniasis in a Human Immunodeficiency Virus Patient Coinfected with Leishmania braziliensis and Its Endosymbiotic Virus (2016) (21)
- Low frequency of LRV1 in Leishmania braziliensis strains isolated from typical and atypical lesions in the State of Minas Gerais, Brazil. (2016) (21)
- Amplification of a new region of DNA in an unselected laboratory stock of L. tarentolae: the T region. (1989) (21)
- A Narnavirus in the Trypanosomatid Protist Plant Pathogen Phytomonas serpens (2016) (20)
- Monitoring the efficacy of antimicrobial photodynamic therapy in a murine model of cutaneous leishmaniasis using L. major expressing GFP (2010) (20)
- Differential Impact of LPG-and PG-Deficient Leishmania major Mutants on the Immune Response of Human Dendritic Cells (2015) (20)
- Molecular evolution inDrosophila and higher diptera (1982) (19)
- Identification of genes mediating lipophosphoglycan biosynthesis by functional complementation of Leishmania donovani mutants. (1995) (19)
- Leishmania donovani has distinct mannosylphosphoryltransferases for the initiation and elongation phases of lipophosphoglycan repeating unit biosynthesis. (1998) (19)
- Evolution of nuclear DNA and the occurrence of sequences related to new small chromosomal DNAs in the trypanosomatid genus Endotrypanum. (1990) (18)
- Stable Transfection oftheHumanParasite Leishmania major Delineates a30-Kilobase Region Sufficient forExtrachromosomal Replication andExpression (1990) (18)
- TLR2 Signaling in Skin Nonhematopoietic Cells Induces Early Neutrophil Recruitment in Response to Leishmania major Infection. (2019) (18)
- Leishmania donovani possess a NADPH-dependent alkylglycerol cleavage enzyme. (1996) (17)
- Crystallization of recombinant Leishmania major pteridine reductase 1 (PTR1). (1999) (17)
- The H region HTBF gene mediates terbinafine resistance in Leishmania major. (2003) (17)
- Identification of genes by functional complementation in protozoan parasite Leishmania (1994) (16)
- Phenylalanine hydroxylase (PAH) from the lower eukaryote Leishmania major. (2011) (16)
- New Mos1 mariner transposons suitable for the recovery of gene fusions in vivo and in vitro. (2001) (16)
- Protective Role of the Neuropeptide Urocortin II against Experimental Sepsis and Leishmaniasis by Direct Killing of Pathogens (2013) (15)
- Tests of heterologous promoters and intergenic regions in Leishmania major. (2000) (15)
- The Evolutionary Loss of RNAi Key Determinants in Kinetoplastids as a Multiple Sporadic Phenomenon (2017) (15)
- Base J represses genes at the end of polycistronic gene clusters in Leishmania major by promoting RNAP II termination (2016) (15)
- Transposition of the Drosophila element mariner within the human malaria parasite Plasmodium falciparum. (2000) (14)
- Genetic and genomic approaches to the analysis of Leishmania virulence (2003) (14)
- Simultaneous transient expression assays of the trypanosomatid parasite Leishmania using beta-galactosidase and beta-glucuronidase as reporter enzymes. (1991) (14)
- Sequence of the dihydrofolate reductase-thymidylate synthase (DHFR-TS) gene of Leishmania amazonensis. (1990) (14)
- The enzymes of the 10-formyl-tetrahydrofolate synthetic pathway are found exclusively in the cytosol of the trypanosomatid parasite Leishmania major. (2009) (13)
- Conservation of the LD1 region in Leishmania includes DNA implicated in LD1 amplification. (2001) (13)
- Parasitology: CRISPR for Cryptosporidium (2015) (13)
- On the introduction of genetically modified Leishmania outside the laboratory. (1994) (12)
- ‘Transient’ genetic suppression facilitates generation of hexose transporter null mutants in Leishmania mexicana (2013) (12)
- Concomitant Immunity Induced by Persistent Leishmania major Does Not Preclude Secondary Re-Infection: Implications for Genetic Exchange, Diversity and Vaccination (2016) (12)
- Genetic metabolic complementation establishes a requirement for GDP-fucose in Leishmania (2017) (12)
- The Leishmania dono 6 ani LD 1 locus gene ORFG encodes a biopterin transporter ( BT 1 ) (1999) (12)
- Gene amplification and drug resistance in cultured animal cells. (1984) (11)
- The antioxidant response favors Leishmania parasites survival, limits inflammation and reprograms the host cell metabolism (2021) (11)
- Leishmania Sexual Reproductive Strategies as Resolved through Computational Methods Designed for Aneuploid Genomes (2021) (11)
- Demonstration by heterologous expression that the Leishmania SCA1 gene encodes an arabinopyranosyltransferase. (2006) (11)
- Remodeling of protein and mRNA expression in Leishmania mexicana induced by deletion of glucose transporter genes. (2011) (11)
- Estimation of circular DNA size using gamma-irradiation and pulsed-field gel electrophoresis. (1989) (11)
- Leishmania major intracellular survival is not altered in SHP-1 deficient mev or CD45-/- mice. (2008) (10)
- Importance of polyphosphate in the Leishmania life cycle (2018) (10)
- Isolation of virulence genes directing GPI synthesis by functional complementation of Leishmania. (1994) (10)
- Dramatic changes in gene expression in different forms of Crithidia fasciculata reveal potential mechanisms for insect-specific adhesion in kinetoplastid parasites (2019) (10)
- In vitro shuttle mutagenesis using engineered mariner transposons. (2004) (9)
- Molecular evolution inDrosophila and the higher diptera (2005) (9)
- SODB1 is essential for Leishmania major infection of macrophages and pathogenesis in mice (2018) (9)
- Flypaper for Parasites (2004) (9)
- Physical mapping across the dihydrofolate reductase–thymidylate synthase chromosome of Leishmania major (1997) (8)
- Priming of a β-Galactosidase (β-GAL)-Specific Type 1 Response in BALB/c Mice Infected with β-GAL-Transfected Leishmania major (2000) (8)
- Genome Assemblies across the Diverse Evolutionary Spectrum of Leishmania Protozoan Parasites (2021) (6)
- Deficiency of Leishmania Phosphoglycans Influences the Magnitude but Does Not Affect the Quality of Secondary (Memory) Anti-Leishmania Immunity (2013) (6)
- Low frequency of LRV 1 in Leishmania braziliensis strains isolated from typical and atypical lesions in the State of Minas Gerais , Brazil (2016) (6)
- Development of a semi-automated image-based high-throughput drug screening system. (2018) (6)
- An essential, kinetoplastid-specific GDP-Fuc: β-D-Gal α-1,2-fucosyltransferase is located in the mitochondrion of Trypanosoma brucei (2019) (6)
- Identification of a DNA fragment that increases mitotic stability of episomal linear DNAs in Leishmania major. (2005) (5)
- Concentration of 2′C-methyladenosine triphosphate by Leishmania guyanensis enables specific inhibition of Leishmania RNA virus 1 via its RNA polymerase (2018) (5)
- REDHORSE-REcombination and Double crossover detection in Haploid Organisms using next-geneRation SEquencing data (2015) (5)
- A broadly active fucosyltransferase LmjFUT1 whose mitochondrial localization and activity are essential in parasitic Leishmania (2021) (5)
- Effects of a Squalene-2,3-Epoxidase Inhibitor on Propagation and Sterol Biosynthesis of Leishmania Promastigotes and Amastigotes (1989) (5)
- Evaluation of α,β-Unsaturated Ketones as Antileishmanial Agents (2015) (4)
- Inositol phosphorylceramide synthase null Leishmania are viable and virulent in animal infections where salvage of host sphingomyelin predominates (2022) (3)
- Leishmania IFT140 mutants show normal viability but lack external flagella: a tool for the study of flagellar function through the infectious cycle (2015) (3)
- African Trypanosomes Find a Fat Haven. (2016) (3)
- Inhibitor of growth protein 3 epigenetically silences endogenous retroviral elements and prevents innate immune activation (2021) (3)
- Feedforward Loop for Diversity (2)
- A requirement for GDP-L-fucose in Leishmania inferred by rescue of D-arabinopyranose/L-fucose salvage mutants (Fkp40(-)/Afkp80(-)) by expression of GDP-L-fuc synthetic enzymes (2009) (2)
- Distribution of dihydrofolate reductase-thymidylate synthetase polypeptide in methotrexateresistant and wild type Leishmania major: Evidence for cytoplasmic distribution despite a hydrophilic leader sequence (1990) (2)
- Leishmania guyanensis suppressed inducible nitric oxide synthase provoked by its viral endosymbiont (2022) (2)
- A broadly active fucosyltransferase LmjFUT1 whose mitochondrial localization and catalytic activity is essential in the parasitic protozoan Leishmania (2021) (2)
- replication and expression. region sufficient for extrachromosomal Leishmania major delineates a 30-kilobase Stable transfection of the human parasite (2013) (2)
- Host-microbe interactions: fungi/viruses/parasites. (1999) (2)
- Amplified DNAs in laboratory stocks of Leishmania tarentolae: extrachromosomal circles structurally and functionally similar to the inverted-H-region amplification of methotrexate-resistant Leishmania major (1988) (1)
- Unstable and Stable Gene Amplification in Methotrexate-Resistant Leishmania Major and Natural Isolates of Leishmania Tarentolae (1989) (1)
- Short communication Genetic nomenclature for Trypanosoma and Leishmania (1998) (1)
- Naturally-occurring gene amplifications conferring drug resistance in Leishmania tarentolae. (1988) (1)
- Self-Hybridization in Leishmania major (2022) (1)
- Mannogen-ing Central Carbon Metabolism by Leishmania. (2019) (1)
- Spontaneous excision and facilitated recovery as a control for phenotypes arising from RNA interference and other dominant transgenes. (2018) (1)
- Short communication The PGPA gene of Leishmania major mediates antimony (SblII) resistance by decreasing influx and not by increasing efflux (1994) (1)
- Digital Commons@Becker Digital Commons@Becker Muco-cutaneous leishmaniasis in the New World: The ultimate Muco-cutaneous leishmaniasis in the New World: The ultimate subversion (2022) (1)
- PLOS Pathogens 2016 Reviewer and Editorial Board Thank You (2017) (1)
- The Association of Leishmania RNA Viruses with metastatic or mucocutaneous Leishmaniasis in South America (2012) (0)
- Expanded Proteomic Survey of the Human Parasite Leishmania major Focusing on Changes in Null Mutants of the Golgi GDP-Mannose/Fucose/Arabinopyranose Transporter LPG2 and of the Mitochondrial Fucosyltransferase FUT1 (2022) (0)
- Sequence and biochemical characterization of equilibrative nucleoside transporters from Crithidia fasciculata: seeking ligand binding residues (2010) (0)
- Running Title : 1 Evaluation of α , β-unsaturated ketones as antileishmanial agents 2 3 (2015) (0)
- Mapping and characterization of the Leishmania (L.) amazonensis genomic region containing the meta 1 gene:: comparative study with the L. (L.) major genome. (2003) (0)
- Rapidduplication andloss ofgenescoding fortheachains ofhemoglobin (restriction endonuclease maps/unequal crossover/noncoding DNA/concerted evolution/primates) (1980) (0)
- In and out: Leishmania metastasis by hijacking lymphatic system and migrating immune cells (2022) (0)
- The role of surface glycoconjugates in Leishmania pathogenicity (2000) (0)
- A new protein-expression platform based on a eukaryotic parasite Leishmania tarentolae (2004) (0)
- Multidrug resistance and gene amplification in cultured Leishmania: relevance to current and prospective chemotherapy. (1990) (0)
- Leishmaniasis by Direct Killing of Pathogensand Urocortin II against Experimental Sepsis Protective Role of the Neuropeptide (2013) (0)
- The sphingolipids ceramide and inositol phosphorylceramide protect the Leishmania major membrane from sterol-specific toxins. (2023) (0)
- WWC Quick Review of “Retrieval Practice Produces More Learning Than Elaborative Studying With Concept Mapping” (2011) (0)
- Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences: 357 (1417) (2002) (0)
- Virulence and Immunization Strategies Glycoconjugates and Its Significance to -Dependent LPG2 Macrophages without Survive as Amastigotes within Able To Leishmania major ) of REV - lpg2of a Compensatory Mutant ( (2014) (0)
- Leishmania identification based on ribosomal rna derived oligonucleotide probing (1993) (0)
- Inducing a Strong Th1 Response Mice from Virulent Challenge without Protects Highly Susceptible Leishmania major Vaccination with Phosphoglycan-Deficient (2004) (0)
- Isolation ofvirulence genesdirecting surface glycosyl- phosphatidylinositol synthesis byfunctional complementation (1993) (0)
- PathogenesisHost Cellular Arginase Activity and Disease and Cytokine-Independent Regulation of Reveals a Parasite Number-Dependent major Leishmania Infection with Arginase-Deficient (2009) (0)
- Purine Salvage Drives the Efficacy of an Adenosine Analog Inhibitor of Leishmania RNA Virus 1 (LRV1) (2017) (0)
- Rapidspontaneous dihydrofolate reductase geneamplification (1983) (0)
- Development of RNAi tools for studying Leishmania (Viannia) and their application to the study of the Leishmania flagellum (2012) (0)
- Sphingolipids protect ergosterol in the Leishmania major membrane from sterol-specific toxins (2022) (0)
- REDHORSE-REcombination and Double crossover detection in Haploid Organisms using next-geneRation SEquencing data (2015) (0)
- Biosynthesis of the GPI-anchored lipophosphoglycan of Leishmania (1998) (0)
- Biochemical and Genetic Analysis of Methylenetetrahydrofolate Reductase (2006) (0)
- A genetic analysis of the biosynthetic pathway of the Leishmania virulence factor LPG. (1997) (0)
- Comparative genomic analysis of Leishmania (Viannia) peruviana and Leishmania (Viannia) braziliensis (2015) (0)
- Localization of Epigenetic Markers in Leishmania Chromatin (2022) (0)
- The acquisition of methotrexate resistance by gene amplification (1984) (0)
- The Evolutionary Loss of RNAi Key Determinants in Kinetoplastids as a Multiple Sporadic Phenomenon (2017) (0)
- Properties of an Altered Dihydrofolate Reductase Amplified Genes in Cultured Mouse Fibroblasts* Encoded by (1981) (0)
- Leishmania Lipophosphoglycan Triggers Caspase-11 and the Non-canonical Activation of the NLRP 3 Inflammasome Graphical Abstract Highlights (2019) (0)
- [Mucocutaneous leishmaniasis and an undesired passenger]. (2011) (0)
- Effects of trans-sialidase enzyme activity, secretion and antigen persistence on the induction of protective immunity against Trypanosoma cruzi infection (VAC8P.1054) (2015) (0)
- Parasite hybridization promotes spreading of endosymbiotic viruses (2023) (0)
- Coupling of p.o!y(A.) site.selection and trans-spucmg m Lezshmama (1993) (0)
- High-efficiency, stable DNA transformation of the human parasite, Leishmania major. (1991) (0)
- Interplay of Trypanosome Lytic Factor and innate immune cells in the resolution of cutaneous Leishmania infection (2020) (0)
- Hijacking the Cell : Minireview Parasites in the Driver ’ s Seat (1996) (0)
- Short communication Transposition of the Drosophila element mariner within the human malaria parasite Plasmodium falciparum (2000) (0)
- A transposon-based tool for transformation and mutagenesis in trypanosomatid protozoa. (2015) (0)
- 1.EIS11MAN1A LPG2. A putative ODP-man transporter is required for GOI.GI GDP-man uptake (1997) (0)
- GLPFN IASYA TLVHIV AKCN LIPGD LIFSGGNTH IYMNHV EQCKE ILR REPKELYE LV ISGLPYKF RYLST KEQLKYVLK LRP KDFV LNNYVSHPP I KKMAV (2003) (0)
- Title: Viral discovery and diversity in trypanosomatids with a focus on relatives of the human parasite Leishmania (2018) (0)
- Conservation of the LD 1 region in Leishmania includes DNA implicated in LD 1 amplification (2001) (0)
- Genetic exchange in Leishmania is facilitated by IgM natural antibodies (2022) (0)
- Quantitative single-cell analysis of Leishmania major amastigote differentiation demonstrates variably extended expression of the lipophosphoglycan (LPG) virulence factor in different host cell types (2022) (0)
- Use of Leishmania major parasites expressing a recombinant Trypanosoma cruzi antigen as live vaccines against Chagas disease (2022) (0)
- An RNA Interference (RNAi) Toolkit and Its Utility for Functional Genetic Analysis of Leishmania (Viannia) (2022) (0)
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