Stephen Neidle
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British X-ray crystallographer, chemist and drug designer
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Chemistry
Why Is Stephen Neidle Influential?
(Suggest an Edit or Addition)According to Wikipedia, Stephen Neidle is a British X-ray crystallographer, chemist and drug designer working at the UCL School of Pharmacy. His area of scientific research has been in nucleic acid structure and recognition, and the research topic of quadruplexes.
Stephen Neidle's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Quadruplex DNA: sequence, topology and structure (2006) (1933)
- Crystal structure of parallel quadruplexes from human telomeric DNA (2002) (1720)
- Targeting G-quadruplexes in gene promoters: a novel anticancer strategy? (2011) (1344)
- Principles of nucleic acid structure (2007) (968)
- Highly prevalent putative quadruplex sequence motifs in human DNA (2005) (835)
- Inhibition of human telomerase by a G-quadruplex-interactive compound. (1997) (704)
- Telomere maintenance as a target for anticancer drug discovery (2002) (553)
- A standard reference frame for the description of nucleic acid base-pair geometry. (2001) (549)
- Putative DNA quadruplex formation within the human c-kit oncogene. (2005) (489)
- G-quadruplex nucleic acids as therapeutic targets. (2009) (485)
- Human telomeric G‐quadruplex: The current status of telomeric G‐quadruplexes as therapeutic targets in human cancer (2010) (480)
- The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function. (2005) (479)
- DNA minor-groove recognition by small molecules. (2001) (406)
- Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors (2001) (402)
- Loop-length-dependent folding of G-quadruplexes. (2004) (402)
- Quadruplex Nucleic Acids as Novel Therapeutic Targets. (2016) (398)
- The structures of quadruplex nucleic acids and their drug complexes. (2009) (395)
- The structure of telomeric DNA. (2003) (394)
- Structure of an unprecedented G-quadruplex scaffold in the human c-kit promoter. (2007) (380)
- A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogene. (2006) (367)
- Oxford handbook of nucleic acid structure (1998) (361)
- Molecular Aspects of Anticancer Drug/DNA Interactions (1993) (329)
- Quadruplex nucleic acids. (2006) (328)
- Stabilization of G-quadruplex DNA and inhibition of telomerase activity by square-planar nickel(II) complexes. (2006) (287)
- Structural basis for binding of porphyrin to human telomeres. (2007) (282)
- Structural basis of DNA quadruplex recognition by an acridine drug. (2008) (272)
- Quadruplex nucleic acids as targets for anticancer therapeutics (2017) (268)
- Crystal structure of the potassium form of an Oxytricha nova G-quadruplex. (2002) (267)
- A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity. (2002) (260)
- Structure of a G-quadruplex-ligand complex. (2003) (238)
- A new class of symmetric bisbenzimidazole-based DNA minor groove-binding agents showing antitumor activity. (2001) (213)
- Chemical approaches to the discovery and development of cancer therapies (2005) (202)
- Structural basis for telomeric G-quadruplex targeting by naphthalene diimide ligands. (2012) (200)
- A crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex (2010) (195)
- 2,7-Disubstituted amidofluorenone derivatives as inhibitors of human telomerase. (1999) (194)
- Stabilization of G-quadruplex DNA by highly selective ligands via click chemistry. (2006) (194)
- Structure of the first parallel DNA quadruplex-drug complex. (2003) (192)
- Natural and synthetic G-quadruplex interactive berberine derivatives. (2006) (184)
- G‐quadruplexes as therapeutic targets (2000) (184)
- Molecular Aspects of Anti-Cancer Drug Action (1983) (182)
- Molecular dynamics and principal components analysis of human telomeric quadruplex multimers. (2008) (180)
- Molecular basis of structure-activity relationships between salphen metal complexes and human telomeric DNA quadruplexes. (2012) (180)
- Conformations of the sugar-phosphate backbone in helical DNA crystal structures. (1997) (180)
- A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics. (2009) (177)
- Trisubstituted acridines as G-quadruplex telomere targeting agents. Effects of extensions of the 3,6- and 9-side chains on quadruplex binding, telomerase activity, and cell proliferation. (2006) (171)
- Structure-specific recognition of quadruplex DNA by organic cations: influence of shape, substituents and charge. (2007) (170)
- G‐quadruplexes: Emerging roles in neurodegenerative diseases and the non‐coding transcriptome (2015) (166)
- Trisubstituted acridine derivatives as potent and selective telomerase inhibitors. (2003) (166)
- "...the tyranny of the lattice...". (1994) (154)
- Crystal structure of a pentamidine-oligonucleotide complex: implications for DNA-binding properties. (1992) (154)
- A G-quadruplex telomere targeting agent produces p16-associated senescence and chromosomal fusions in human prostate cancer cells. (2004) (153)
- Topology conservation and loop flexibility in quadruplex-drug recognition: crystal structures of inter- and intramolecular telomeric DNA quadruplex-drug complexes. (2008) (153)
- Human telomerase inhibition by substituted acridine derivatives. (1999) (148)
- G‐quadruplex‐binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo (2017) (147)
- Human telomerase inhibition by regioisomeric disubstituted amidoanthracene-9,10-diones. (1998) (145)
- Small-molecule quadruplex-targeted drug discovery. (2014) (145)
- Structural and sequence-dependent aspects of drug intercalation into nucleic acids. (1984) (144)
- Structure-based design and evaluation of naphthalene diimide G-quadruplex ligands as telomere targeting agents in pancreatic cancer cells. (2013) (143)
- 1,4- and 2,6-disubstituted amidoanthracene-9,10-dione derivatives as inhibitors of human telomerase. (1998) (142)
- Molecular modeling studies on G-quadruplex complexes of telomerase inhibitors: structure-activity relationships. (1999) (138)
- Shedding light on the interaction between TMPyP4 and human telomeric quadruplexes. (2009) (138)
- Quadruplex DNA crystal structures and drug design. (2008) (132)
- Sequence occurrence and structural uniqueness of a G-quadruplex in the human c-kit promoter (2007) (132)
- Mechanism of acridine-based telomerase inhibition and telomere shortening. (2007) (130)
- Crystal structure of FMN-dependent nitroreductase from Escherichia coli B: a prodrug-activating enzyme. (2000) (128)
- DNA structure and perturbation by drug binding. (1987) (126)
- Targeting human gastrointestinal stromal tumor cells with a quadruplex-binding small molecule. (2009) (126)
- The molecular basis for the action of some DNA-binding drugs. (1979) (124)
- Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands. (2008) (122)
- Rational design of a highly efficient irreversible DNA interstrand cross-linking agent based on the pyrrolobenzodiazepine ring system (1992) (119)
- Crystal structure of a c-kit promoter quadruplex reveals the structural role of metal ions and water molecules in maintaining loop conformation (2012) (117)
- The structure of drug-deoxydinucleoside phosphate complex; generalized conformational behavior of intercalation complexes with RNA and DNA fragments (1980) (116)
- Structural basis of telomeric RNA quadruplex--acridine ligand recognition. (2011) (115)
- Effects of metal coordination geometry on stabilization of human telomeric quadruplex DNA by square-planar and square-pyramidal metal complexes. (2008) (115)
- Selectivity in ligand recognition of G-quadruplex loops. (2009) (114)
- Highly structured water network in crystals of a deoxydinucleoside–drug complex (1980) (111)
- Electrospray mass spectrometry of telomeric RNA (TERRA) reveals the formation of stable multimeric G-quadruplex structures. (2010) (111)
- A structural analysis of G-quadruplex/ligand interactions. (2011) (109)
- The design of G-quadruplex ligands as telomerase inhibitors. (2003) (109)
- Molecular structure of the B-DNA dodecamer d(CGCAAATTTGCG)2. An examination of propeller twist and minor-groove water structure at 2.2 A resolution. (1992) (107)
- Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands. (2001) (107)
- The structure of the antitumor complex cis-(diammino) (1,1-cyclobutanedicarboxylato)-Pt(II): X ray and nmr studies (1980) (106)
- A thermodynamic and structural analysis of DNA minor-groove complex formation. (2000) (105)
- Crystal structure of a berenil‐dodecanucleotide complex: the role of water in sequence‐specific ligand binding. (1990) (101)
- Structure of a dinucleoside phosphate–drug complex as model for nucleic acid–drug interaction (1977) (100)
- A novel inhibitor of human telomerase derived from 10H-indolo[3,2-b]quinoline. (2000) (100)
- A role for water molecules in DNA-ligand minor groove recognition. (2009) (99)
- Stabilisation of human telomeric quadruplex DNA and inhibition of telomerase by a platinum-phenanthroline complex. (2007) (98)
- Rational design of acridine-based ligands with selectivity for human telomeric quadruplexes. (2010) (96)
- Synthesis and evaluation of analogues of 10H-indolo[3,2-b]quinoline as G-quadruplex stabilising ligands and potential inhibitors of the enzyme telomerase. (2004) (96)
- Nucleic Acid Structure and Recognition (2002) (95)
- Studies on the nitroreductase prodrug-activating system. Crystal structures of complexes with the inhibitor dicoumarol and dinitrobenzamide prodrugs and of the enzyme active form. (2003) (95)
- Synthesis of Sequence-Selective C8-Linked Pyrrolo[2,1-c][1,4]benzodiazepine DNA Interstrand Cross-Linking Agents. (1996) (93)
- DNA structure and recognition. (1994) (92)
- Sequence-dependent effects in drug-DNA interaction: the crystal structure of Hoechst 33258 bound to the d(CGCAAATTTGCG)2 duplex. (1994) (92)
- Comparative computer graphics and solution studies of the DNA interaction of substituted anthraquinones based on doxorubicin and mitoxantrone. (1985) (91)
- The structure of a pseudo intercalated complex between actinomycin and the DNA binding sequence d(GpC) (1982) (90)
- Bioactive pyridine-N-oxide disulfides from Allium stipitatum. (2009) (89)
- TRAP-LIG, a modified telomere repeat amplification protocol assay to quantitate telomerase inhibition by small molecules. (2008) (89)
- Non‐random usage of ‘degenerate’ codons is related to protein three‐dimensional structure (1996) (88)
- Tetrasubstituted naphthalene diimide ligands with selectivity for telomeric G-quadruplexes and cancer cells. (2010) (88)
- Crystallographic insights into DNA minor groove recognition by drugs (1997) (88)
- Characterization of a novel DNA minor-groove complex. (2004) (87)
- Topics in Nucleic Acid Structure (1981) (86)
- Targeting Multiple Effector Pathways in Pancreatic Ductal Adenocarcinoma with a G-Quadruplex-Binding Small Molecule (2018) (85)
- Netropsin, a DNA-binding oligopeptide structural and binding studies. (1979) (85)
- Crystal structure of a berenil-d(CGCAAATTTGCG) complex. An example of drug-DNA recognition based on sequence-dependent structural features. (1992) (85)
- A G-quadruplex-binding compound showing anti-tumour activity in an in vivo model for pancreatic cancer (2015) (85)
- Interaction of berenil with the EcoRI dodecamer d(CGCGAATTCGCG)2 in solution studied by NMR. (1991) (85)
- Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets. (2012) (84)
- A crystallographic and spectroscopic study of the complex between d(CGCGAATTCGCG)2 and 2,5-bis(4-guanylphenyl)furan, an analogue of berenil. Structural origins of enhanced DNA-binding affinity. (1995) (82)
- Folding of guanine quadruplex molecules-funnel-like mechanism or kinetic partitioning? An overview from MD simulation studies. (2016) (81)
- Synthesis and biophysical studies of short oligodeoxynucleotides with novel modifications: a possible approach to the problem of mixed base oligodeoxynucleotide synthesis. (1984) (79)
- Structure of a covalent DNA minor groove adduct with a pyrrolobenzodiazepine dimer: evidence for sequence-specific interstrand cross-linking. (1994) (77)
- Structural characterization of a guanine-quadruplex ligand complex. (2000) (77)
- Crystal structure of an oligonucleotide duplex containing G.G base pairs: influence of mispairing on DNA backbone conformation. (1993) (76)
- Targeting the minor groove of DNA: crystal structures of two complexes between furan derivatives of berenil and the DNA dodecamer d(CGCGAATTCGCG)2. (1996) (75)
- A detailed molecular model for human aromatase (1993) (75)
- A molecular model for the enzyme cytochrome P45017α, a major target for the chemotherapy of prostatic cancer (1990) (73)
- Thiophene-based diamidine forms a "super" at binding minor groove agent. (2004) (73)
- Evaluation of by disubstituted acridone derivatives as telomerase inhibitors: the importance of G-quadruplex binding. (2004) (70)
- KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines (2015) (70)
- Anthracene-9,10-diones as potential anticancer agents. Synthesis, DNA-binding, and biological studies on a series of 2,6-disubstituted derivatives. (1992) (69)
- Strong binding in the DNA minor groove by an aromatic diamidine with a shape that does not match the curvature of the groove. (2002) (68)
- The relationship of potential G-quadruplex sequences in cis-upstream regions of the human genome to SP1-binding elements (2008) (68)
- Fluorine in medicinal chemistry: β-fluorination of peripheral pyrrolidines attached to acridine ligands affects their interactions with G-quadruplex DNA. (2011) (67)
- A DNA-porphyrin minor-groove complex at atomic resolution: the structural consequences of porphyrin ruffling. (2000) (67)
- Protein and drug interactions in the minor groove of DNA. (2002) (67)
- ANALYSIS OF VAN-DER-WAALS AND ELECTROSTATIC CONTRIBUTIONS IN THE INTERACTIONS OF MINOR-GROOVE BINDING BENZIMIDAZOLES WITH DNA (1995) (66)
- Conformational dynamics of the human propeller telomeric DNA quadruplex on a microsecond time scale (2013) (65)
- Selectivity in small molecule binding to human telomeric RNA and DNA quadruplexes. (2009) (64)
- Rational design of substituted diarylureas: a scaffold for binding to G-quadruplex motifs. (2008) (64)
- Observation of the coexistence of sodium and calcium ions in a DNA G-quadruplex ion channel. (2007) (63)
- Nucleic acid binding drugs. Part IV. The crystal structure of the anti-cancer agent daunomycin. (1977) (63)
- G-quadruplexes and metal ions. (2012) (63)
- A new plant-derived antibacterial is an inhibitor of efflux pumps in Staphylococcus aureus. (2013) (63)
- Targeting the c-Kit Promoter G-quadruplexes with 6-Substituted Indenoisoquinolines. (2010) (62)
- Observation of unphosphorylated STAT3 core protein binding to target dsDNA by PEMSA and X‐ray crystallography (2013) (62)
- Substituent position dictates the intercalative DNA-binding mode for anthracene-9,10-dione antitumor drugs. (1992) (62)
- Predictive modelling of topology and loop variations in dimeric DNA quadruplex structures (2006) (61)
- Topology variation and loop structural homology in crystal and simulated structures of a bimolecular DNA quadruplex. (2006) (61)
- Water-mediated binding of agents that target the DNA minor groove. (2011) (61)
- Effect of linker length on DNA-binding affinity, cross-linking efficiency and cytotoxicity of C8-linked pyrrolobenzodiazepine dimers (1992) (61)
- Detection and kinetic studies of triplex formation by oligodeoxynucleotides using real-time biomolecular interaction analysis (BIA). (1995) (60)
- Crystal structure of the DNA decamer d(CGCAATTGCG) complexed with the minor groove binding drug netropsin. (1997) (60)
- Recent developments in triple-helix regulation of gene expression. (1997) (59)
- Therapeutic Applications of Quadruplex Nucleic Acids (2011) (59)
- Crystal and molecular structure of three isomers of dichlorodiamminedihydroxoplatinum(IV): cis-trans isomerization on recrystallization from water (1984) (59)
- Flexibility and structural conservation in a c-KIT G-quadruplex (2014) (59)
- Small-molecule binding to the DNA minor groove is mediated by a conserved water cluster. (2013) (59)
- Structure-based design of benzylamino-acridine compounds as G-quadruplex DNA telomere targeting agents. (2007) (59)
- Sequence-specific minor groove binding by bis-benzimidazoles: water molecules in ligand recognition. (2003) (58)
- Out-of-shape DNA minor groove binders: induced fit interactions of heterocyclic dications with the DNA minor groove. (2005) (58)
- Structure of the oligonucleotide d(CGTATATACG) as a site-specific complex with nickel ions. (1999) (58)
- The non-covalent interaction of pyrrolo[2, 1-c] [1, 4]benzodiazepine-5, 11-diones with DNA. (1990) (57)
- Targeting pancreatic cancer with a G-quadruplex ligand. (2011) (56)
- Synthesis, biophysical and biological evaluation of 3,6-bis-amidoacridines with extended 9-anilino substituents as potent G-quadruplex-binding telomerase inhibitors. (2004) (56)
- Structure-activity relationships among guanine-quadruplex telomerase inhibitors. (2000) (55)
- A molecular anchor for stabilizing triple-helical DNA. (1995) (54)
- Hitting the target (1999) (53)
- Molecular modeling and simulation of G-quadruplexes and quadruplex-ligand complexes. (2010) (53)
- Aminoacyl-anthraquinone conjugates as telomerase inhibitors: synthesis, biophysical and biological evaluation. (2008) (53)
- NMR and molecular modeling studies of the interaction of berenil and pentamidine with d(CGCAAATTTGCG)2. (1993) (53)
- Sequence-dependent drug binding to the minor groove of DNA: crystal structure of the DNA dodecamer d(CGCAAATTTGCG)2 complexed with propamidine. (1995) (53)
- Crystal structure of d(CGCGAATTCGCG) complexed with propamidine, a short-chain homologue of the drug pentamidine. (1993) (53)
- A molecular model for proflavine-DNA intercalation. (1988) (53)
- N-cyclic bay-substituted perylene G-quadruplex ligands have selective antiproliferative effects on cancer cells and induce telomere damage. (2011) (52)
- Equilibrium and Kinetic Measurements Reveal Rapidly Reversible Binding of Ras to Raf (*) (1996) (52)
- Molecular modelling of the interactions of tetra-(4-N-methylpyridyl) porphin with TA and CG sites on DNA. (1987) (52)
- Synthesis, molecular modeling, DNA binding, and antitumor properties of some substituted amidoanthraquinones. (1988) (52)
- Structural Insights into the Quadruplex-Duplex 3' Interface Formed from a Telomeric Repeat: A Potential Molecular Target. (2016) (52)
- Induced fit conformational changes of a "reversed amidine" heterocycle: optimized interactions in a DNA minor groove complex. (2007) (50)
- Effect of metal coordination on the interaction of substituted phenanthroline and pyridine ligands with quadruplex DNA. (2009) (50)
- Drug-nucleic acid interactions: conformational flexibility at the intercalation site. (1978) (48)
- Molecular and crystal structure of an intercalation complex: Proflavine–cytidylyl‐(3′,5′)‐guanosine (1979) (47)
- Recognition and discrimination of DNA quadruplexes by acridine-peptide conjugates. (2009) (47)
- Sequence-selective targeting of long stretches of the DNA minor groove by a novel dimeric bis-benzimidazole. (2003) (47)
- A new crystal form for the dodecamer C-G-C-G-A-A-T-T-C-G-C-G: symmetry effects on sequence-dependent DNA structure. (2000) (46)
- Designer DNA-binding drugs: the crystal structure of a meta-hydroxy analogue of Hoechst 33258 bound to d(CGCGAATTCGCG)2. (1996) (46)
- Toward the Development of Specific G-Quadruplex Binders: Synthesis, Biophysical, and Biological Studies of New Hydrazone Derivatives. (2016) (45)
- Crystal structure and sequence-dependent conformation of the A.G mispaired oligonucleotide d(CGCAAGCTGGCG). (1990) (45)
- Synthesis of distamycin A polyamides targeting G-quadruplex DNA. (2006) (44)
- Extended molecular dynamics of a c-kit promoter quadruplex (2015) (44)
- The crystal structure of a-D-glucose monohydrate (1973) (43)
- Targeting KRAS Oncogene in Colon Cancer Cells with 7-Carboxylate Indolo[3,2-b]quinoline Tri-Alkylamine Derivatives (2015) (43)
- Interaction of berenil with the tyrT DNA sequence studied by footprinting and molecular modelling. Implications for the design of sequence-specific DNA recognition agents. (1990) (43)
- Molecular-mechanics modelling of drug-DNA structures; the effects of differing dielectric treatment on helix parameters and comparison with a fully solvated structural model. (1990) (43)
- X-ray crystallographic studies of nucleic acids and nucleic acid-drug complexes. (1983) (42)
- Targeting a c-MYC G-quadruplex DNA with a fragment library. (2014) (42)
- Crystal structure of a promoter sequence in the B-raf gene reveals an intertwined dimer quadruplex. (2013) (42)
- Biaryl polyamides as a new class of DNA quadruplex-binding ligands. (2009) (42)
- On the function of the internal cavity of histone deacetylase protein 8: R37 is a crucial residue for catalysis. (2011) (41)
- Structure-based design of selective high-affinity telomeric quadruplex-binding ligands. (2010) (41)
- Recognition of GC base pairs by triplex forming oligonucleotides containing nucleosides derived from 2-aminopyridine. (1997) (41)
- Chemical variation of natural-product-like scaffolds: design, synthesis, and biological activity of fused bicyclic acetal derivatives. (2007) (41)
- Symmetric bis-benzimidazoles: new sequence-selective DNA-binding molecules (1999) (41)
- The crystal structure of an orthorhombic form of adenosine-5'-monophosphate (1976) (40)
- Mechanistic and anti-proliferative studies of two novel, biologically active bis-benzimidazoles. (2003) (40)
- New mustard-linked 2-aryl-bis-benzimidazoles with anti-proliferative activity. (2006) (40)
- Efficient triple helix formation by oligodeoxyribonucleotides containing alpha- or beta-2-amino-5-(2-deoxy-D-ribofuranosyl) pyridine residues. (1996) (40)
- Bioactive Compounds from Carissa spinarum (2012) (40)
- DNA sequence preferences for an intercalating porphyrin compound revealed by footprinting. (1987) (40)
- Virtual screening of DNA minor groove binders. (2006) (39)
- Telomerase as an anti-cancer target: current status and future prospects. (1999) (39)
- Variability in DNA minor groove width recognised by ligand binding: the crystal structure of a bis-benzimidazole compound bound to the DNA duplex d(CGCGAATTCGCG)2. (1995) (38)
- Loop flexibility in human telomeric quadruplex small-molecule complexes (2015) (38)
- Crystal structure of human DT-diaphorase: a model for interaction with the cytotoxic prodrug 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954). (1999) (38)
- DNA sequence preferences for the anti‐cancer drug mitoxanthrone and related anthraquinones revealed by DNase I footprinting (1986) (38)
- Telomerase inhibitors in cancer therapy: current status and future directions. (2003) (37)
- Synthesis, G‐Quadruplex Stabilisation, Docking Studies, and Effect on Cancer Cells of Indolo[3,2‐b]quinolines with One, Two, or Three Basic Side Chains (2013) (36)
- A molecular model for drug binding to tandem repeats of telomeric G-quadruplexes. (2009) (36)
- G-quadruplex compounds and cis-platin act synergistically to inhibit cancer cell growth in vitro and in vivo. (2009) (36)
- Acquired cellular resistance to flavopiridol in a human colon carcinoma cell line involves up-regulation of the telomerase catalytic subunit and telomere elongation. Sensitivity of resistant cells to combination treatment with a telomerase inhibitor. (2003) (36)
- Binding of unfused aromatic cations to DNA. The influence of molecular twist on intercalation (1988) (35)
- The crystal structure of the DNA-binding drug berenil: molecular modelling studies of berenil-DNA complexes. (1987) (35)
- Minor‐groove width and accessibility in B‐DNA drug and protein complexes (1992) (35)
- Structure-activity relationships of monomeric C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumor agents. (2010) (35)
- A 1:2 crystalline complex of ApA:proflavine: a model for binding to single-stranded regions in RNA. (1978) (35)
- Mapping the sequences of potential guanine quadruplex motifs (2011) (34)
- Design, synthesis and evaluation of 4,5-di-substituted acridone ligands with high G-quadruplex affinity and selectivity, together with low toxicity to normal cells. (2009) (34)
- Exploring the recognition of quadruplex DNA by an engineered Cys2-His2 zinc finger protein. (2006) (34)
- Rationally designed analogues of tamoxifen with improved calmodulin antagonism. (1995) (34)
- Exploring the Dynamics of Propeller Loops in Human Telomeric DNA Quadruplexes Using Atomistic Simulations (2017) (34)
- The triazatruxene derivative azatrux binds to the parallel form of the human telomeric G-quadruplex under molecular crowding conditions: biophysical and molecular modeling studies. (2011) (33)
- Targeting telomerase and telomeres: a click chemistry approach towards highly selective G-quadruplex ligands. (2008) (33)
- Conformation and dynamics of drug-DNA intercalation. (1992) (33)
- Cancer drug design and discovery (2008) (33)
- Molecular dynamics simulation of the DNA triplex d(TC)5.d(GA)5.d(C+T)5. (1992) (32)
- Molecular models for the interaction of the anti-tumour drug nogalamycin with DNA. (1984) (32)
- Cytotoxicity of bis(phenylamidinium)furan alkyl derivatives in human tumour cell lines: Relation to DNA minor groove binding (1997) (32)
- Isohelicity and phasing in drug--DNA sequence recognition: crystal structure of a tris(benzimidazole)--oligonucleotide complex. (1996) (31)
- Inhibition of the hypoxia-inducible factor pathway by a G-quadruplex binding small molecule (2013) (31)
- Structure of a bis-amidinium derivative of hoechst 33258 complexed to dodecanucleotide d(CGCGAATTCGCG)2: the role of hydrogen bonding in minor groove drug-DNA recognition. (1997) (31)
- Amide bond direction modulates G-quadruplex recognition and telomerase inhibition by 2,6 and 2,7 bis-substituted anthracenedione derivatives. (2008) (31)
- Click chemistry assembly of G-quadruplex ligands incorporating a diarylurea scaffold and triazole linkers. (2008) (31)
- DNA minor groove interactions and the biological activity of 2,5-bis. (2000) (31)
- Crystal structure of a DNA decamer showing a novel pseudo four-way helix-helix junction. (1995) (30)
- A click chemistry approach to C3 symmetric, G-quadruplex stabilising ligands. (2010) (30)
- Small‐molecule G‐quadruplex interactions: Systematic exploration of conformational space using multiple molecular dynamics (2013) (30)
- Macrocyclic naphthalene diimides as G-quadruplex binders. (2015) (30)
- Identification of novel telomeric G-quadruplex-targeting chemical scaffolds through screening of three NCI libraries. (2012) (29)
- Crystal and solution structures of the oligonucleotide d(ATGCGCAT)2: a combined X-ray and NMR study. (1990) (29)
- Mechanism of the Antiproliferative Activity of Some Naphthalene Diimide G-Quadruplex Ligands (2013) (29)
- DNA minor groove recognition of a non-self-complementary AT-rich sequence by a tris-benzimidazole ligand (1999) (29)
- Triazole-acridine conjugates: redox mechanisms and in situ electrochemical evaluation of interaction with double-stranded DNA. (2013) (29)
- Tetrapeptides induce selective recognition for G-quadruplexes when conjugated to a DNA-binding platform. (2004) (28)
- The high resolution crystal structure of the DNA decamer d(AGGCATGCCT). (1996) (28)
- Crystallography of DNA and RNA G‐Quadruplex Nucleic Acids and Their Ligand Complexes (2012) (28)
- Stabilisation of TG- and AG-containing antiparallel DNA triplexes by triplex-binding ligands. (2001) (27)
- Design, synthesis and evaluation of human telomerase inhibitors based upon a tetracyclic structural motif. (1999) (27)
- An Integrated Sequence-Structure Database incorporating matching mRNA sequence, amino acid sequence and protein three-dimensional structure data (1998) (27)
- A Role for Water Molecules in DNA—Ligand Minor Groove Recognition (2009) (27)
- Anthracene-9,10-diones as potential anticancer agents: bacterial mutation studies of amido-substituted derivatives reveal an unexpected lack of mutagenicity. (1998) (27)
- High-resolution crystal structure of the intramolecular d(TpA) thymine–adenine photoadduct and its mechanistic implications (2007) (27)
- Monte Carlo studies on water in the dCpG/proflavin crystal hydrate. (1983) (27)
- A novel series of G-quadruplex ligands with selectivity for HIF-expressing osteosarcoma and renal cancer cell lines. (2012) (26)
- Can We Execute Reliable MM-PBSA Free Energy Computations of Relative Stabilities of Different Guanine Quadruplex Folds? (2016) (26)
- The crystal and molecular structure of an osmium bispyridine adduct of thymine. (1976) (26)
- Antibacterial activity of head-to-head bis-benzimidazoles. (2013) (26)
- Stabilization of DNA triple helices by a series of mono- and disubstituted amidoanthraquinones. (1999) (26)
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- Structural basis for the identification of an i-motif tetraplex core with a parallel-duplex junction as a structural motif in CCG triplet repeats. (2014) (23)
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- Symmetric bis-benzimidazoles are potent anti-staphylococcal agents with dual inhibitory mechanisms against DNA gyrase. (2012) (22)
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- Bis-guanylhydrazone diimidazo[1,2-a:1,2-c]pyrimidine as a novel and specific G-quadruplex binding motif. (2010) (20)
- Visualisation of extensive water ribbons and networks in a DNA minor-groove drug complex. (1998) (20)
- Selective G-quadruplex ligands: the significant role of side chain charge density in a series of perylene derivatives. (2009) (20)
- Studies on the conformation and dynamics of the C8-substituted guanine adduct of the carcinogen acetylaminofluorene; model for a possible Z-DNA modified structure. (1984) (20)
- Inhibitors of the P450 enzymes aromatase and lyase. Crystallographic and molecular modeling studies suggest structural features of pyridylacetic acid derivatives responsible for differences in enzyme inhibitory activity. (1990) (20)
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- DNA Quadruplexes and Gene Regulation (2006) (19)
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- The Interactions of Daunomycin Adriamycin with Nucleic Acids (1983) (18)
- Bis(acetato)amminedichloro(cyclohexylamine)platinum(IV), an orally active anticancer drug. (1995) (18)
- Homology modelling of the enzyme P450 17 alpha-hydroxylase/17,20-lyase--a target for prostate cancer chemotherapy--from the crystal structure of P450BM-3. (1997) (18)
- Drug action at the molecular level (1976) (17)
- The influence of positional isomerism on G-quadruplex binding and anti-proliferative activity of tetra-substituted naphthalene diimide compounds. (2013) (17)
- The structure of the ribodinucleoside monophosphate guanylyl‐3',5'‐cytidine as its ammonium octahydrate salt (1983) (17)
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- Developing and paying for medicines for orphan indications in oncology: utilitarian regulation vs equitable care? (2012) (17)
- New insights into sequence-dependent DNA structure (1998) (16)
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- The relevance of drug DNA sequence specificity to anti-tumour activity. (1994) (16)
- X-ray crystallographic analysis of 3-(2'-phenyl-2,4'-bithiazole-4-carboxamido) propyldimethylsulphonium iodide, an analogue of the DNA-binding portion of bleomycin A2. (1982) (16)
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- Truncated azinomycin analogues intercalate into DNA. (2005) (16)
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- Molecular aspects of anticancer drug-DNA interactions (vol. 1) (1994) (14)
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- Platinum(II) complexes of nitroimidazoles: synthesis, characterisation, and X-ray crystal structures of cis-dichlorobis[1-(2′-hydroxyethyl)-2-hydroxymethyl-5-nitroimidazole]platinum(II) and trans-dichlorobis[1-(2′-hydroxy-3′-methoxypropyl)-2-nitroimidazole]platinum(II) (1985) (12)
- Crystal and molecular structure of viridin (1972) (12)
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- Nucleic acid binding drugs. X. A theoretical study of proflavine intercalation into RNA and DNA fragments: comparison with crystallographic results (1984) (11)
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- The crystal structure of 5-benzoyloxyoctaethylporphyrin. An example of a distorted porphyrin ring (1972) (8)
- A benzoquinone Di-imine from the oxidation of pentafluoroaniline by hypochlorite. X-Ray crystal structure and possible formation via pentafluorophenylnitrene (1989) (8)
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- Synthesis and biological evaluation of hybrid acridine-HSP90 ligand conjugates as telomerase inhibitors. (2015) (8)
- Combining 1,3‐Ditriazolylbenzene and Quinoline to Discover a New G‐Quadruplex‐Interactive Small Molecule Active against Cancer Stem‐Like Cells (2019) (8)
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- Reply: Comment on ‘Developing and paying for medicines for orphan indications in oncology: utilitarian regulation vs equitable care?’ (2012) (8)
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- Factors involved in guanine/cytosine (G/C) selectivity of DNA-binding drugs: a molecular modelling study of ligand interactions with a tyrT DNA sequence (1993) (6)
- The structure of a hydrated 1:2 complex of adenylyl(3'‐5')adenosine–proflavine hemisulphate (1982) (6)
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- Nucleic acid binding drugs. Part 12. X-Ray crystallographic and conformational studies on the anti-cancer drug m-AMSA and its mesyl derivative (1985) (5)
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- DNA triple helices. A molecular dynamics study (1991) (3)
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- Some developments in cancer chemotherapy. (1978) (1)
- The structure of 3'-deoxyformycin hydrochloride (1987) (1)
- X-RAY CRYSTAL AND MOLECULAR STRUCTURE OF CIS(N,N′),TRANS(O,O′)-BIS-(2-AMINOETHANOLATO)-CIS-DICHLOROPLATINUM(IV) DIHYDRATE. THE RELATIONSHIP OF ANTITUMOR ACTIVITY TO RING CLOSURE (1983) (1)
- CRYSTAL STRUCTURE OF HUMAN NATIVE CKIT PROTO-ONCOGENE PROMOTER QUADRUPLEX DNA (2014) (1)
- CONFORMATION OF THE C8 SUBSTITUTED GUANINE ADDUCT OF THE CARCINOGEN ACETYLAMINOFLUORENE - MODEL FOR A POSSIBLE Z-DNA MODIFIED STRUCTURE (1984) (1)
- A structural study of 3'‐deoxytubercidin and 3‐deaza‐3'‐deoxyadenosine (1987) (1)
- Drug-Nucleic Acid Interactions at the Molecular Level (2018) (1)
- The structure of 3,5-di-O-benzoyl-1,2-dideoxy-1-phenyl-β-D-ribofuranose, C25H22O5 (1985) (1)
- A new class of non-covalent sequence-selective DNA groove-binders with potential antitumour activity (1989) (1)
- Solution and Solid State Structure of 2′,5′-BIS-(O-Trityl)-3′-Oximinouridine (1993) (1)
- The crystal and molecular structure of 2',3',5'‐tri‐O‐acetyl‐6‐O‐(mesitylenesulphonyl)guanosine (1978) (1)
- THE SECOND C-KIT DNA QUADRUPLEX CRYSTAL STRUCTURE (2014) (1)
- Structure of 5'‐chloro‐3',5'‐dideoxyformycin A monohydrate. The effects of protonation on formycin structure and conformation (1990) (1)
- Nucleic acid binding drugs. VIII. Structures of 1-[2-(diethylamino)ethylamino]anthracene-9,10-dione, C20H22N2O2 (I) and 1,5-bis[2-(diethylamino)ethylamino]anthracene-9,10-dione, C26H36N4O2 (II), models for antitumour drugs (1983) (1)
- The Biology and Pharmacology of Telomeric Quadruplex Ligands (2012) (1)
- Chapter 2:Molecular Dynamics and Force Field Based Methods for Studying Quadruplex Nucleic Acids (2012) (1)
- Crystal structure and sequence-dependent conformation of the A-G mispaired (1)
- Structure of 1,2-dideoxy-1-(3-pyridyl)-α-d-ribofuranose (1987) (1)
- Computer graphics in rational anti-cancer drug design (1982) (1)
- Drug Nucleic Acid Interactions: Proflavine Intercalation into Double-Helical Fragments of RNA and DNA (1983) (1)
- Nucleic Acid—Metal Ion Interactions : Metal Ions in Biology, volume 1 Edited by T.G. Spiro John Wiley and Sons; Brisbane, Chichester, New York, Toronto, 1980 (1981) (1)
- Abstract LB-2: Structure-based design of G-quadruplex ligands leads to enhanced potency against pancreatic cancer cells (2012) (1)
- THE STRUCTURE OF 6,9-DICHLORO-2-METHOXYACRIDINE (1982) (1)
- Structures of Two DNA Minor‐Groove Binders, Based on Pyrrolo(2,1‐c)(1, 4)benzodiazepines. (1992) (1)
- Crystal structure of the berenil-D(CGCGAATTCGCG)2 complex at 1.65 A resolution. (2007) (1)
- Synthesis of the Farnesyl Ether 2,3,5‐Trifluoro‐6‐hydroxy‐4‐ [(E,E)‐3,7,11‐trimethyldodeca‐2,6,10‐trien‐1‐yloxy]nitrobenzene, and Related Compounds Containing a Substituted Hydroxytrifluorophenyl Residue: Novel Inhibitors of Protein Farnesyltransferase, Geranylgeranyltransferase I and Squalene Synth (2001) (1)
- Structure of 1‐(p‐methoxyphenyl)‐trans‐1,2‐diphenylbut‐1‐ene (1982) (1)
- CRYSTALLIZATION OF TRANSFER RNA-LEU (CUG) FROM ESCHERICHIA-COLI AFTER PURIFICATION WITH HYDROXYAPATITE (1979) (1)
- A model for the [C+-G center dot C](n) triple helix derived from observation of the C+-G center dot C base triplet in a crystal structure (1997) (1)
- Nonstandard and Higher-Order DNA Structures: DNA–DNA Recognition (2008) (1)
- CRYSTAL STRUCTURE OF THE A-DNA OCTAMER D(GGCATGCC) (1996) (1)
- Studies on the Nitroreductase Prodrug-Activating System. Crystal Structures of the Enzyme Active Form and Complexes with the Inhibitor Dicoumarol and Dinitrobenzamide Prodrugs (2003) (1)
- The mechanism of resistance in Escherichia coli to ridinilazole and other antibacterial head-to-head bis-benzimidazole compounds (2022) (1)
- myo‐Inositol 1,3,5‐Bicyclic Phosphate (1998) (1)
- The role of chemical sciences in 21st century cancer drug discovery. (2005) (1)
- Structure of 5′-Chloro-3′,5′-dideoxyformycin A Monohydrate. The Effects of Protonation on Formycin Structure and Conformation. (1991) (1)
- Deeper insights into tRNA (1976) (1)
- Structure and conformational features of 9‐(4‐diethylaminophenyl)acridine (1990) (1)
- Computer-aided design of new DNA intercalators. (1986) (1)
- Nucleic acid binding drugs. XVII. Structures of 4-substituted analogues of the antitumour drug amsacrine (1987) (1)
- Cancer: Science and Society : by John Cairns W. H. Freeman; San Francisco, 1978 xiv + 200 pages. £2.90 (softcover), £6.20 (hardcover) (1980) (1)
- G‐Quadruplexes as Therapeutic Targets in Cancer (2013) (1)
- Synthesis and structure of 3‐(4‐carbamoylphenyl)‐1,3‐dimethyltriazene 1‐oxide (1987) (1)
- Crystallographic studies of fusicoccin and two mercuribromide derivatives (1968) (1)
- Non-standard and higher-order DNA structures: DNA–DNA recognition (2022) (1)
- Crystal structure of the DB1880-D(CGCGAATTCGCG)2 complex (2005) (1)
- Triazole-linked phenyl derivatives: redox mechanisms and in situ electrochemical evaluation of interaction with dsDNA. (2015) (1)
- NUCLEIC-ACID BINDING DRUGS .4. CRYSTAL-STRUCTURE OF ANTI-CANCER AGENT DAUNOMYCIN (1977) (1)
- Targeting imatinib-resistant gastrointestinal stromal tumors by down-regulation of KIT gene expression with quadruplex-stabilizing small molecules (2007) (1)
- Structure of 9‐amino‐2,7‐di‐tert‐butylacridine (1992) (1)
- X-Ray crystallographic determination of the molecular structures of cis- and trans-isomers of (±)-5-fluorocyclophosphamide {2-[bis-(2-chloroethyl)amino]-5-fluorotetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide]} (1981) (1)
- Advances in Computational and Medicinal Chemistry Preface (2016) (0)
- Faculty Opinions recommendation of RNA G-quadruplexes (rG4s): genomics and biological functions. (0)
- Abstract 5454: Novel STAT3:STAT3 small-molecule inhibitors as potential anticancer agents (2010) (0)
- THE ROLE OF HYDROGEN BONDING IN MINOR-GROOVE DRUG-DNA RECOGNITION. STRUCTURE OF A BIS-AMIDINIUM DERIVATIVE OF HOECHST 33258 COMPLEXED TO THE DODECANUCLEOTIDE D(CGCGAATTCGCG)2 (1997) (0)
- NllCleiC Acids Research A 1:2 crystalline complex of ApA:proflavine: a model for binding to single-stranded reigons in RNA (2005) (0)
- Nucleic acid binding drugs. 18: Calculated charges for a DNA intercalation complex; a study of the relative influence of polarization and conformational effects (1987) (0)
- Abstract 2517: Hybrid benzofused-biaryl polyamides with selective telomeric G-quadruplex stabilization potential (2011) (0)
- Structure of the Human G-quadruplex reveals a novel topology (2002) (0)
- Crystal structure of an oligonucleotide duplex containing GG base pairs : Influence of mispairing on DNA backbone conformation ( x-ray crystallography DNA structure ) (0)
- EDITORIAL Oncology Research Incorporating Anti-Cancer Drug Design (2002) (0)
- Monomeric G-DNA tetraplex from human C-kit promoter (2007) (0)
- Phasing in drug-DNA sequence recognition: structure of a tris(benzimidazole)–DNA complex (1996) (0)
- Abstract 3679: Targeting drug-resistant GIST cells with a quadruplex-binding small molecule (2010) (0)
- PLATINUM(II) COMPLEXES OF NITROIMIDAZOLES: SYNTHESIS, CHARACTERIZATION, AND X-RAY CRYSTAL STRUCTURES OF CIS-DICHLOROBIS(1-(2′-HYDROXYETHYL)-2-HYDROXYMETHYL-5-NITROIMIDAZOLE)PLATINUM(II) AND TRANS-DICHLOROBIS(1-(2′-HYDROXY-3′-METHOXYPR (1985) (0)
- Abstract B030: The quadruplex-binding compound QN-302 targets the S100P gene in PDAC (2022) (0)
- CRYSTAL STRUCTURE OF 1-(MESITYL-2-SULFONYL)-3-NITRO-1,2,4-TRIAZOLE (1982) (0)
- 4-amino-1-(2-deoxy-β-D-ribofuranosyl)-6,7-dihydro-1H,5H-cyclopentapyrimidine-2-one (1996) (0)
- Metal-containing stabilisers of G-quadruplex DNA as telomerase inhibitors. (2005) (0)
- Molecular mechanisms and therapeutic strategies in amyotrophic lateral sclerosis caused by C9orf72 mutations (2016) (0)
- The Targeting of Quadruplex Nucleic Acids in Human Cancers (2019) (0)
- Guardians of science, fairness and reliability of peer review by H.-D. Daniel Weinheim: VCH 1993. 118 pp. hdbk. ISBN 3–527–29041–9 (1994) (0)
- Chapter 2. Physical methods and techniques. Part (ii) X-Ray crystallography (1977) (0)
- NUCLEIC ACID BINDING DRUGS. PART 12. X-RAY CRYSTALLOGRAPHIC AND CONFIRMATIONAL STUDIES ON THE ANTICANCER DRUG M-AMSA AND ITS MESYL DERIVATIVE (1985) (0)
- Structure of N-phenyl-5,6,7,8-tetrahydrodibenzo[a,i]carbazole (1987) (0)
- Correction to Targeting the c-Kit Promoter G-quadruplexes with 6-Substituted Indenoisoquinolines (2010) (0)
- Structures of 1-(3,3-dimethylamino)propyl naphtho[2,1-b]thiophene-4- carboxylate and N-(3,3-dimethylamino)propyl-8-methoxynaphtho[2,1- b]thiophene-4-carboxamide, intercalators into double-helical DNA. (1991) (0)
- Preface (2020) (0)
- Structural studies on carcinogenic polycyclic aromatic hydrocarbons and their active metabolites; some insights into modes of action (1981) (0)
- A bimolecular anti-parallel-stranded Oxytricha nova telomeric quadruplex in complex with a 3,6-disubstituted acridine BSU-6045 (2008) (0)
- Small-molecule interactions of six Oxytricha nova G-quadruplex-ligand complexes studied by X-ray crystallography (2007) (0)
- STRUCTURE OF 2,5-BIS{[4-(N-ETHYLAMIDINO)PHENYL]}FURAN COMPLEXED TO 5'-D(CPGPCPGPAPAPTPTPCPGPCPG)-3'. A MINOR GROOVE DRUG COMPLEX, SHOWING PATTERNS OF GROOVE HYDRATION (1998) (0)
- COMPARATIVE COMPUTER GRAPHICS AND SOLUTION STUDIES OF THE DNA INTERACTION OF SUBSTITUTED ANTHRAQUINONES BASED ON DOXORUBICIN AND MITOXANTRONE (1985) (0)
- Abstract 2326: The first crystal structure of a telomeric quadruplex DNA with a metal-containing ligand (2011) (0)
- Drug dna intercalation the design of new anti cancer agents by computer modelling methods (1991) (0)
- COMPLEX OF D(CCTAGG) WITH TETRA-[N-METHYL-PYRIDYL] PORPHYRIN (2000) (0)
- Substituted 1,1,2, -triphenylbutene and their use for the treatment and diagnosis of cancer (1993) (0)
- X-ray studies of the crystal structures of some biologically significant molecules (1970) (0)
- Incomplete structural model of a human telomeric DNA quadruplex-acridine complex. (2011) (0)
- Abstract 2323: Molecular modeling studies of the STAT3 homodimer:DNA complex (2011) (0)
- The Potent G-Quadruplex-Binding Compound QN-302 Downregulates S100P Gene Expression in Cells and in an In Vivo Model of Pancreatic Cancer (2023) (0)
- Abstract 4981: The potent quadruplex-binding compound QN-302 down-regulates the S100P gene in in vitro and in vivo models of pancreatic cancer: a potential therapeutic target and biomarker for PDAC (2023) (0)
- Crystal Structure of the Oxytricha Telomeric DNA at 1.6A (2002) (0)
- Nucleic acid targeted drug design : C. L. Propst and T. J. Perun (editors), Dekker, New York, 1992. Pages xiii + 619. $165.00. ISBN 0-8247-8662-9. (1994) (0)
- Symmetric Bis‐benzimidazoles: New Sequence‐Selective DNA‐Binding Molecules. (1999) (0)
- Abstract B166: Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets. (2011) (0)
- Abstract 390: A comparison of the activity of the quadruplex-targeting experimental drugs QN-302 and CX-5461 (pidnarulex) in wild-type and gemcitabine-resistant pancreatic cancer cell lines (2023) (0)
- Structure-based design of G-quadruplex ligands leads to enhanced potency against pancreatic cancer cells (2012) (0)
- Faculty Opinions recommendation of DNA G-quadruplex formation in response to remote downstream transcription activity: long-range sensing and signal transducing in DNA double helix. (2013) (0)
- Structure-based design and evaluation of small molecules with selectivity for telomeric quadruplex nucleic acids (2010) (0)
- 2',3'-Dideoxy-3'-nitrothymidine and 2'-propoxy-3'-nitrothymidine (1996) (0)
- THE CRYSTAL STRUCTURE OF THE DNA DECAMER D(GGCAATTGCG) CONTAINS BOTH MAJOR AND MINOR GROOVE BINDING G.(G.C) TRIPLETS (1998) (0)
- Abstract 2310: Down-regulating BCL-2 gene expression in a resistant GIST cell line by a RNA G-quadruplex interacting small molecule ligand (2011) (0)
- Chapter 11:Molecular Modelling Approaches for Assessing Quadruplex–Small Molecule Interactions (2018) (0)
- Design of small molecule drugs targeting quadruplex nucleic acids (2009) (0)
- Crystal structure of a telomeric RNA G-quadruplex complexed with an acridine-based ligand. (2011) (0)
- A bimolecular anti-parallel-stranded Oxytricha nova telomeric quadruplex in complex with a 3,6-disubstituted acridine BSU-6054 (2008) (0)
- A MINOR FMN-DEPENDENT NITROREDUCTASE FROM ESCHERICHIA COLI B (2000) (0)
- Crystal Structure of a Non-Self Complementary DNA Dodecamer Containing an A/T Tract: Analysis of the Effect of Crystal Environment on Local Helical Parameters (2004) (0)
- Structural aspects of quadruplexes as potential therapeutic targets (2006) (0)
- INOR 151-Stabilization of quadruplex DNA and inhibition of telomerase by square planar metal complexes (2007) (0)
- Evaluation of strong binding interaction of a linear biphenyl benzimidazole diamidine in the DNA minor groove (2006) (0)
- Chemoenzymatic Preparation of the Novel Antifolate Thymidylate Synthase Inhibitor N‐(4‐{N‐[(6S)‐2‐Methyl‐4‐oxo‐3,4,7,8‐tetrahydro‐6H‐cyclopenta [g]quinazolin‐6‐yl]‐N‐(prop‐2‐ynyl)amino}benzoyl)‐L‐glutamic Acid (Ia) and Its Glutamyl Cleavage Product (Ib). (1999) (0)
- Molecular Structural Approaches to the Rational Design of New Anticancer Agents (1995) (0)
- B-raf dimer DNA quadruplex (2013) (0)
- Structure and Packing of Human Telomeric DNA (2002) (0)
- Abstract 739: Targeting pancreatic cancers with a quadruplex-binding small molecule (2010) (0)
- Synthesis and evaluation of ligands based on the actinomycin chromophore as novel G-quadruplex stabilising ligands (2008) (0)
- Structure of the A-DNA octamer d(GGCATGCC). (1997) (0)
- Linear structure of the Holliday junction sequence (TCGGCGCCGA) (2014) (0)
- Abstract #668: The development of new telomere-targeted G-quadruplex stabilizing ligands using click chemistry (2009) (0)
- SUGAR STRUCTURES IN DINUCLEOSIDE PHOSPHATE - DRUG COMPLEXES (1981) (0)
- The α‐Pyridyl Nucleoside Analogue 2‐Bromo‐5‐(2‐deoxy‐α‐d‐ribofuranosyl)pyridine (1996) (0)
- The first crystal structure of a human telomeric G-quadruplex DNA bound to a metal-containing ligand (a copper complex) (2011) (0)
- X-ray structural studies on three analogues of the α-anomer of the antitumour antibiotic showdomycin. Different ring-puckering effects of hydroxyl sugar substituents in lyxo and arabino configurations (1990) (0)
- Crystal structures of two furan derivatives of berenil and d(CGCGAATTCGCG)2 (1996) (0)
- SYNTHESIS OF 9-[CIS-3-(HYDROXYMETHYL)CYCLOBUTYL]-ADENINE AND 9-[CIS-3-(HYDROXYMETHYL)CYCLOBUTYL]-GUANINE (1995) (0)
- Faculty Opinions recommendation of Structural insights into synthetic ligands targeting A-A pairs in disease-related CAG RNA repeats. (2019) (0)
- CRYSTAL STRUCTURE OF HUMAN DT-DIAPHORASE (NAD(P)H OXIDOREDUCTASE) (2000) (0)
- A bimolecular anti-parallel-stranded Oxytricha nova telomeric quadruplex in complex with a 3,6-disubstituted acridine BSU-6042 in a large unit cell (2008) (0)
- Synergistic binding of actinomycin D and echinomycin to DNA mismatch sites and their combined anti-tumour effects. (2023) (0)
- Faculty Opinions recommendation of Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex. (2018) (0)
- META-HYDROXY ANALOGUE OF HOECHST 33258 ('HYDROXYL OUT' CONFORMATION) BOUND TO D(CGCGAATTCGCG)2 (1997) (0)
- Molecular structure of (not equal to)3,4-epoxycyclopenta[cd]pyrene; an X-ray crystallographic study. (1983) (0)
- The building blocks of DNA and RNA (2022) (0)
- Telomeric Quadruplex Ligands II: Polycyclic and Non-fused Ring Compounds (2012) (0)
- Antibiotics affecting DNA function (1983) (0)
- 4,5 disubstituted acridones with high selectivity for telomeric G-quadruplex and low toxicity in normal cells (2007) (0)
- The unprecedented structure of a G-quadruplex formed in the human c-kit promoter (2007) (0)
- Crystallisation of tRNALeuCUG from Escherichia coli after purification with hydroxyapatite. (1979) (0)
- Computer modelling and drug design (1992) (0)
- STRUCTURE OF BENZ[A]ANTHRACENE-7,12-DIONE (1982) (0)
- Quadruplex nucleic acids as targets in cancer drug discovery (2020) (0)
- Crystal structure of the brominated CKIT-1 proto-oncogene promoter quadruplex DNA (2012) (0)
- Faculty Opinions recommendation of Structure of the human telomere in K+ solution: a stable basket-type G-quadruplex with only two G-tetrad layers. (2009) (0)
- Crystal structure of the B-DNA decamer d(CGCAATTGCG)2: sequence-dependent crossed helix packing (1996) (0)
- Crystallographic and molecular modelling studies on polycyclic aromatic hydrocarbons (1984) (0)
- Crystal structure of a telomeric RNA quadruplex (2010) (0)
- DNA promoter sequence of the c-kit oncogene forms a parallel G-quadruplex (c-kit2) with a long loop that confers asymmetric internal dynamics in the G-tetrads (2009) (0)
- The Role of the 2-Methyl Substituent in Governing Stereoselective Formation of the E Isomer (II) in the Synthesis of 4-Hydroxy-2-methyltamoxifen (1-(4-(2-(Dimethylamino)ethoxy)phenyl)-1-(4-hydroxy-2-methylphenyl)-2-phenylbut-1-ene). (1988) (0)
- DNA Triple Helices a Molecular Dynamics Study (1991) (0)
- Nitroreductase from e-coli in complex with the dinitrobenzamide prodrug SN27217 (2003) (0)
- 113 Novel small-molecule inhibitors of Interleukin-6 (IL-6) signalling (2010) (0)
- Crystal andsolution structures oftheoligonucleotide d(ATGCGCAT)2: acombined X-ray andNMR study (1990) (0)
- 823 Transcriptional down-regulation of the androgen receptor by promoter G-quadruplex stabilisation; a potential alternative treatment in castrate-resistant prostate cancer (2013) (0)
- Assessment of single agent activity of BRACO19 and combination studies with cytotoxic drugs in a human tumor model with short telomeres. (2003) (0)
- CONFORMATIONAL PROPERTIES OF ADDUCTS BETWEEN DOUBLE-HELICAL DNA FRAGMENTS AND 2-ACETYLAMINOFLUORENE (1983) (0)
- PHYSICAL METHODS .3. X-RAY CRYSTALLOGRAPHY (1975) (0)
- G4T3G4 dimeric quadruplex structure (2006) (0)
- Methods for studying nucleic acid structure (2022) (0)
- Preface. Unlocking nature through Chemistry. (2014) (0)
- A bimolecular anti-parallel-stranded Oxytricha nova telomeric quadruplex in complex with a 3,6-disubstituted acridine BSU-6048 (2008) (0)
- Structure-activity relationships of acridine derivatives via click chemistry: A novel class of G-quadruplex binding ligands (2008) (0)
- Abstract A079: The quadruplex-binding compound QN-302 in the MIA-PaCa2 pancreatic adenocarcinoma model shows no evidence of cardiac or neurological liabilities at therapeutic doses (2022) (0)
- DNA structure as observed in fibres and crystals (2022) (0)
- Hierarchical Nanotube Self‐Assembly of DNA Minor Groove‐Binding Ligand DB921 via Alkali Halide Triggering (2019) (0)
- Effects of Protein Binding on DNA G-Quadruplex Structures (2011) (0)
- STRUCTURE OF A PLATINUM(II) COMPLEX OF 1-BETA-D-ARABINOFURANOSYL)CYTOSINE (1978) (0)
- Principles of small molecule–DNA recognition (2022) (0)
- Crystal structure of D(G4T4G4) with four quadruplexes in the asymmetric unit. (2007) (0)
- Erratum: Targeting the c-kit promoter G-quadruplexes with 6-substituted indenoisoquinolines (ACS Medicinal Chemistry Letters (2010) 1 (306) DOI: 10.1021/ml100062z) (2010) (0)
- The alpha-pyridyl nucleoside analogue 2-bromo-5-(2-deoxy-alpha-D-ribofuranosyl)pyridine (1996) (0)
- Biological Macromolecules and Assemblies (1985) (0)
- Faculty Opinions recommendation of G-Quadruplex Induction by the Hairpin Pyrrole-Imidazole Polyamide Dimer. (2017) (0)
- DNA MINOR-GROOVE RECOGNITION OF A TRIS-BENZIMIDAZOLE DRUG (1999) (0)
- The crystal and molecular structure of streptomycin (2016) (0)
- New twists to left-handed DNA. (1983) (0)
- Oxidative Ring Contraction of Benzeneselenenate Adducts of Glycal Ethers. Synthesis of Showdomycin Analogues. (1988) (0)
- The molecular structure of (+/-)-8 alpha, 9 beta, 10 beta, 11 alpha-tetrahydroxy -8, 9, 10, 11--tetrahydrobenz[a]anthracene; an X-ray crystallographic analysis. (1981) (0)
- MOLECULAR-MODELLING AND BIOPHYSICAL STUDIES ON MODIFIED AND UNMODIFIED OLIGONUCLEOTIDES (1984) (0)
- A THEORETICAL APPROACH TO THE PRESELECTION OF CARCINOGENS AND CHEMICAL CARCINOGENESIS - VELJKOVIC,V (1982) (0)
- DNA quadruplexes: Structures and their recognition. (2003) (0)
- Comment on MaaniHessari, N.; van Schalkwyk, M.C.; Thomas, S.; Petticrew, M. Alcohol Industry CSR Organisations: What Can Their Twitter Activity Tell Us about Their Independence and Their Priorities? A Comparative Analysis. Int. J. Environ. Res. Public Health 2019, 16, 892 (2019) (0)
- A molecular modelforproflavine-DNA intercalation (1988) (0)
- The molecular structure of (+/-)- 7 alpha, 8 beta-dihydroxy-7,8-dihydrobenzo[a]pyrene, an early metabolite of benzo[a]pyrene. (1981) (0)
- A bimolecular parallel-stranded human telomeric quadruplex in complex with a 3,6,9-trisubstituted acridine molecule BRACO19 (2008) (0)
- Crystal Structure of the Quadruplex DNA-Drug Complex (2003) (0)
- Can we Execute Reliable MM-PBSA Free Energy Computations of Relative Energies of Different Guanine Quadruplex Folds ? (2017) (0)
- The structure of 1-(16-hydroxy-phenoxymethyl)-3,4-dihydroisoquinoline hydrochloride monohydrate, a topical anti-viral agent (1974) (0)
- Mobility and function in proteins and nucleic acids edited by R. Porter, M. O'Connor and J. Whelan (1985) (0)
- Structure of 2,3‐dihydro‐1H‐imidazo[1,2‐b]pyrazole (IMPY), an inhibitor of DNA synthesis, C5H7N3 (1983) (0)
- Antisense Nucleic Acids and Proteins: Fundamentals and Applications: Edited by J.N.M. Mol and A.R. van der Krol Marcel Dekker Inc, New York, 1991, pp 248, $114.50 (1994) (0)
- Molecular structure of (+/-) 7alpha,8beta-dihydroxy 9beta, 10beta-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene; an X-ray crystallographic study. (1980) (0)
- Nitroreductase from e-coli in complex with the inhibitor dicoumarol (2003) (0)
- Targeting telomeric RNA quadruplexes (2009) (0)
- A D(TGGGGT)- sodium and calcium complex. (2007) (0)
- The use of molecular modeling in anticancer drug design (1989) (0)
- Chapter 2. Physical methods. Part (iii)X-Ray crystallography (1973) (0)
- PHYSICAL METHODS AND TECHNIQUES .2. X-RAY CRYSTALLOGRAPHY (1977) (0)
- Microsoft Word-ND manuscript revision 26-11-12[1] (2012) (0)
- Transfer RNA revisited (1974) (0)
- Crystallographic studies of DNA minor groove binding drugs (2011) (0)
- Crystal structure of a 1:1 complex between netropsin and d(CGCAATTGCG)2 (1996) (0)
- 435 Biophysical, biological, and in silico investigation of 3,6,9-trisubstituted acridines targeting human telomeric G-quadruplex DNA (2004) (0)
- CRYSTAL AND MOLECULAR STRUCTURE OF (23R)-23-HYDROXY-3ALPHA,5ALPHA-CYCLOERGOST-7-EN-6-ONE (1973) (0)
- The Determination of Quadruplex Structures (2012) (0)
- Structural studies on DNA minor groove recognition by drugs (1993) (0)
- CRYSTAL STRUCTURE OF THE DB 921-D(CGCAAATTTGCG)2 COMPLEX AT 1.42 A RESOLUTION (2013) (0)
- SYNTHESIS OF A NEW PENTACYCLIC SYSTEM : PYRROLO[2,1-c]QUINAZOLlNO[3,2-a][1,4]BENZODIAZEPINES: ELUCIDATION OF STRUCTURES (1995) (0)
- Book Reviews : A Theoretical Approach to the Preselection of Carcinogens and Chemical Carcinogenesis, by Veljko Veljkovic. Published by Gordon and Breach, 1981. 114 pp. Price $36.50 (1982) (0)
- 348 Targeting pancreatic cancers with a G-quadruplex binding small molecule (2010) (0)
- Synthesis of the Aromatase Inhibitor 3-Ethyl-3-(4-pyridyl)piperidine-2,6-dione and Its Enantiomers. (1989) (0)
- 545 Biological effects of G-Quadruplex binding agents in various human cancer cell lines (2004) (0)
- Structure of complex between cyclohexyl-bis-furamidine and d(CGCGAATTCGCG) (2000) (0)
- Molecular dynamics simulation of higher-order G-quadruplex complexes in telomeric DNA (2007) (0)
- Cyclo-butyl-bis-furamidine complexed with dCGCGAATTCGCG (2000) (0)
- Design and development of quadruplex-targeted agents in human cancer (2014) (0)
- Faculty Opinions recommendation of Re-evaluation of G-quadruplex propensity with G4Hunter. (2016) (0)
- Drug-DNA sequence recognition in the minor groove (1995) (0)
- G-quadruplex formation at telomere ends: A strategy for selective interference with telomere maintenance in tumour cells (2003) (0)
- Principles of protein–DNA recognition (2022) (0)
- Abstract #5355: Design, synthesis and evaluation of naphthalene-diimides as potent and selective telomeric G-quadruplex ligands (2009) (0)
- DRUG-DNA MINOR GROOVE RECOGNITION: CRYSTAL STRUCTURE OF GAMMA-OXAPENTAMIDINE COMPLEXED WITH D(CGCGAATTCGCG)2 (1994) (0)
- Variability in the geometry of RNA double helices generated from dinucleoside building-blocks. (1985) (0)
- A Benzoquinone Diimine from the Oxidation of Pentafluoroaniline by Hypochlorite. X-Ray Crystal Structure and Possible Formation via Pentafluorophenylnitrene. (1989) (0)
- diimide G-quadruplex ligands (2012) (0)
- STRUCTURAL STUDIES ON A PRODRUG-ACTIVATING SYSTEM-CB1954 AND FMN-DEPENDENT NITROREDUCTASE (2003) (0)
- Crystal structure of an intramolecular human telomeric DNA G-quadruplex 21-mer bound by the naphthalene diimide compound BMSG-SH-3 (2013) (0)
- 5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3'-SYMMETRIC BIS-BENZIMIDAZOLE COMPLEX (2001) (0)
- Ligand binding and structural rearrangements of quadruplexes containing human telomeric sequences (2008) (0)
- G4(Br)UTTG4 dimeric quadruplex (2006) (0)
- Repressors at the molecular level (1974) (0)
- Rational design and evaluation of substituted acridones and acridines as telomerase inhibitors. (2003) (0)
- European School of Oncology Task Force Report. New approaches in cancer pharmacology: drug design and development (Part 2). (1994) (0)
- Abstract 4068: The potent quadruplex-binding compound SOP1812 shows potent anti-proliferative activity in a prostate cancer cell panel and anti-tumor activity in an in vivo model of metastatic prostate cancer (2022) (0)
- Daunomycin/d(TGGGGT): the first crystal structure of a drug bound to a G4-quadruplex DNA telomere (2002) (0)
- STRUCTURE OF A COMPLEX BETWEEN THE DNA SEQUENCE DCGCGAATTCGCG AND BIS[PIPERIDINO-ETHYL]-FURAMIDINE (2000) (0)
- Crystal structure of a DB1055-D(CGCGAATTCGCG)2 complex (2005) (0)
- The Structures of Human Telomeric DNA Quadruplexes (2012) (0)
- Nucleic acid binding drugs. XVI. Structure of (7R)‐trans‐7,11‐di‐O‐acetyl‐4‐demethoxydaunomycinone, an analogue of the antitumour compound daunomycin (1987) (0)
- There's more to chemistry (2004) (0)
- NUCLEIC-ACID-BINDING DRUGS .3. STRUCTURE OF MIRACIL D, A DNA-BINDING DRUG (1976) (0)
- A parallel stranded human telomeric quadruplex in complex with the porphyrin TMPyP4 (2007) (0)
- Abstract #5354: Biaryl polyamides as a new class of G-quadruplex ligands (2009) (0)
- A bimolecular anti-parallel-stranded Oxytricha nova telomeric quadruplex in complex with a 3,6-disubstituted acridine BSU-6066 (2008) (0)
- Structural Bioinformatics in Cancer (2006) (0)
- Structural studies on sequence selectivity in drug-nucleic acid interactions. (1985) (0)
- Crystal structure of the DB 911- D(CGCGAATTCGCG)2 complex at 2.05 A resolution. (2007) (0)
- A bimolecular anti-parallel-stranded Oxytricha nova telomeric quadruplex in complex with a 3,6-disubstituted acridine ligand containing bis-3-fluoropyrrolidine end side chains (2010) (0)
- Derivatives of 2′,3′-Dithiouridine and (1-β-D-(2,3- Dithioxylofuranosyl))uracil. (1993) (0)
- RNA binding proteins (2022) (0)
- Nitroreductase from e-coli in complex with the dinitrobenzamide prodrug SN23862 (2003) (0)
- Orthorhombic form of Oxytricha telomeric DNA at 2.0A (2002) (0)
- Faculty Opinions recommendation of Small-molecule-induced DNA damage identifies alternative DNA structures in human genes. (2012) (0)
- Abstract 4069: The potent quadruplex-binding compound SOP1812 shows anti-tumor activity in patient-derived in vivo models of pancreatic cancer (2022) (0)
- 2′,3′-Anhydrouridine. A Useful Synthetic Intermediate. (1999) (0)
- Crystal structure of DNA(CGCGAATTCGCG)2 at 1.25 angstroms (2013) (0)
- Physical methods. Part (III) X-Ray crystallography (1973) (0)
- Nucleic acids and molecular biology—Volume 3 (1990) (0)
- A bimolecular anti-parallel-stranded Oxytricha nova telomeric quadruplex in complex with a 3,6-disubstituted acridine BSU-6038 (2008) (0)
- X‐RAY CRYSTALLOGRAPHIC DETERMINATION OF THE MOLECULAR STRUCTURES OF CIS‐ AND TRANS‐ISOMERS OF (.+‐.)‐5‐FLUOROCYCLOPHOSPHAMIDE (2‐(BIS‐(2‐CHLOROETHYL)AMINO)‐5‐FLUOROTETRAHYDRO‐2H‐1,3,2‐OXAZAPHOSPHORINE 2‐OXIDE) (1981) (0)
- Synthesis of 9‐(cis‐3‐(Hydroxymethyl)cyclobutyl)‐adenine and ‐guanine. (1996) (0)
- All parallel G-quadruplex from the promoter sequence of the c-kit oncogene (2009) (0)
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