Stephen Powis
#35,232
Most Influential Person Now
National medical director for England, in the National Health Service
Why Is Stephen Powis Influential?
(Suggest an Edit or Addition)According to Wikipedia, Sir Stephen Huw Powis is national medical director for England, in the National Health Service , appointed at the start of 2018 to succeed Sir Bruce Keogh. He is also a professor of renal medicine at University College London.
Stephen Powis's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Large-scale chromatin organization of the major histocompatibility complex and other regions of human chromosome 6 and its response to interferon in interphase nuclei. (2000) (477)
- Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy. (2011) (431)
- Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex (1992) (417)
- A proteasome-related gene between the two ABC transporter loci in the class II region of the human MHC (1991) (416)
- Homozygous human TAP peptide transporter mutation in HLA class I deficiency. (1994) (350)
- Second proteasome-related gene in the human MHC class II region (1991) (349)
- EPA and DHA reduce LPS-induced inflammation responses in HK-2 cells: evidence for a PPAR-gamma-dependent mechanism. (2005) (342)
- Restoration of endogenous antigen processing in Burkitt's lymphoma cells by Epstein‐Barr virus latent membrane protein‐1: coordinate up‐regulation of peptide transporters and HLA‐class I antigen expression (1995) (227)
- Functional characterization of HLA‐F and binding of HLA‐F tetramers to ILT2 and ILT4 receptors (2000) (217)
- Inflammatory stress exacerbates lipid accumulation in hepatic cells and fatty livers of apolipoprotein E knockout mice (2008) (213)
- Identification of a novel psoriasis susceptibility locus at 1p and evidence of epistasis between PSORS1 and candidate loci (2001) (146)
- Mechanisms of Dysregulation of Low-Density Lipoprotein Receptor Expression in Vascular Smooth Muscle Cells by Inflammatory Cytokines (2006) (117)
- PPAR agonists protect mesangial cells from interleukin 1beta-induced intracellular lipid accumulation by activating the ABCA1 cholesterol efflux pathway. (2003) (114)
- Dysregulation of LDL receptor under the influence of inflammatory cytokines: a new pathway for foam cell formation. (2001) (114)
- Characterization of the major susceptibility region for psoriasis at chromosome 6p21.3. (1999) (113)
- A non-HLA gene within the MHC in psoriasis (1999) (107)
- Phospholipase A2 receptor (PLA2R1) sequence variants in idiopathic membranous nephropathy. (2013) (102)
- The safety and efficacy of MMF in lupus nephritis: a pilot study (2001) (89)
- The genetic architecture of membranous nephropathy and its potential to improve non-invasive diagnosis (2020) (78)
- Plasma Concentrations of Mycophenolic Acid Acyl Glucuronide Are Not Associated with Diarrhea in Renal Transplant Recipients (2007) (77)
- Anti-atherosclerotic effects of sirolimus on human vascular smooth muscle cells. (2007) (74)
- Alleles and haplotypes of the MHC-encoded ABC transporters TAP1 and TAP2 (1993) (67)
- Analysis of the MHC class II encoded components of the HLA class I antigen processing pathway in ankylosing spondylitis. (1994) (62)
- Risk HLA-DQA 1 and PLA 2 R 1 Alleles in Idiopathic Membranous Nephropathy (2011) (62)
- Calculated glomerular filtration rate is a useful screening tool to identify scleroderma patients with renal impairment. (2003) (59)
- Human mesangial cells express inducible macrophage scavenger receptor. (1999) (59)
- Major histocompatibility complex class I-related chain A allele mismatching, antibodies, and rejection in renal transplantation. (2011) (55)
- Chronic inflammation exacerbates glucose metabolism disorders in C57BL/6J mice fed with high-fat diet. (2013) (49)
- Inflammatory Stress Induces Statin Resistance by Disrupting 3-Hydroxy-3-Methylglutaryl-CoA Reductase Feedback Regulation (2014) (46)
- Inflammatory cytokines disrupt LDL-receptor feedback regulation and cause statin resistance: a comparative study in human hepatic cells and mesangial cells. (2007) (45)
- Regulation of lipoprotein trafficking in the kidney: role of inflammatory mediators and transcription factors. (2004) (44)
- Long‐ and short‐term outcomes in renal allografts with deceased donors: A large recipient and donor genome‐wide association study (2018) (44)
- Sirolimus Modifies Cholesterol Homeostasis in Hepatic Cells: A Potential Molecular Mechanism for Sirolimus-Associated Dyslipidemia (2007) (42)
- Hyperoxia improves the survival of intraportally transplanted syngeneic pancreatic islets (2003) (41)
- Inflammatory stress exacerbates ectopic lipid deposition in C57BL/6J mice (2011) (40)
- Advanced glycation end products (AGEs) increase human mesangial foam cell formation by increasing Golgi SCAP glycosylation in vitro. (2011) (40)
- MHC-encoded TAP1 and TAP2 dimorphisms in multiple sclerosis. (1994) (40)
- An antigen processing polymorphism revealed by HLA‐B8‐restricted cytotoxic T lymphocytes which does not correlate with TAP gene polymorphism (1993) (38)
- Analysis of the MHC-encoded transporters TAP1 and TAP2 in rheumatoid arthritis: linkage with DR4 accounts for the association with a minor TAP2 allele. (1993) (37)
- Genetic risk variants for membranous nephropathy: extension of and association with other chronic kidney disease aetiologies (2017) (36)
- Calcineurin inhibitors enhance low-density lipoprotein oxidation in transplant patients. (1999) (31)
- Time Course and Quantification of Pancreatic Islet Revasculariztion following Intraportal Transplantation (2007) (30)
- Oxidizability of low-density lipoproteins from Neoral and tacrolimus-treated renal transplant patients. (1998) (28)
- Genetic risk variants for membranous nephropathy: extension of and association with other chronic kidney disease aetiologies. (2017) (27)
- TAP1 and TAP2 polymorphism in coeliac disease (2004) (27)
- Alleles and haplotypes of the MHC-encoded ABC transporters TAP1 and TAP2 (2004) (27)
- Sirolimus inhibits endogenous cholesterol synthesis induced by inflammatory stress in human vascular smooth muscle cells. (2010) (27)
- Significance of cytokine gene polymorphism in renal transplantation. (2001) (27)
- Renovascular disease is associated with low producer genotypes of the anti-inflammatory cytokine interleukin-10. (2004) (25)
- Time course and quantification of pancreatic islet revascularization following intraportal transplantation. (2007) (25)
- Effects of sirolimus on mesangial cell cholesterol homeostasis: a novel mechanism for its action against lipid-mediated injury in renal allografts. (2005) (24)
- What is the MHC? (1995) (23)
- Cholesterol granuloma of the kidney mimicking a tumour. (2003) (23)
- Limited polymorphism in HLA-DM does not involve the peptide binding groove (2004) (22)
- Inflammatory stress exacerbates lipid-mediated renal injury in ApoE/CD36/SRA triple knockout mice. (2011) (22)
- A meta-analysis of the impact of the two-layer method of preservation on human pancreatic islet transplantation. (2008) (17)
- Nuclear receptors and their coregulators in kidney. (2005) (16)
- Use of Perfluorodecalin for Pancreatic Islet Culture Prior to Transplantation: A Liquid-Liquid Interface Culture System—Preliminary Report (2011) (15)
- A Meta-Analysis of the Impact of the Two-Layer Method of Preservation on Human Pancreatic Islet Transplantation (2008) (14)
- Time Course of Islet Loss after Intraportal Transplantation (2008) (12)
- Inflammatory stress reduces the effectiveness of statins in the kidney by disrupting HMGCoA reductase feedback regulation. (2014) (12)
- Human mesangial cells express inducible macrophage scavenger receptor: an Ap-1 and ets mediated response. (1999) (11)
- Limited Penetration of Perfluorocarbon in Porcine Pancreas Preserved by Two-Layer Method with 19Fluorine Magnetic Resonance Spectroscopy and Headspace Gas Chromatography (2010) (11)
- Major histocompatibility haplotypes associated with immunoglobulin-A deficiency and common variable immunodeficiency: analysis of the peptide transporter genes TAP1 and TAP2. (1994) (11)
- Platelet-activating factor (PAF) increase intracellular lipid accumulation by increasing both LDL and scavenger receptors in human mesangial cells. (2006) (10)
- ANCA +ve vasculitis after autologous PBSC transplantation. (2002) (10)
- Dysregulation of LDL receptor by an inflammatory cytokine: A new pathway for foam cell formation in vascular smooth muscle cells. (2003) (9)
- Glomeruloid haemangioma and POEMS syndrome. (2001) (9)
- Effect of inspired oxygen on portal and hepatic oxygenation: effective arterialization of portal blood by hyperoxia. (2004) (9)
- Effect of Inspired Oxygen on Portal and Hepatic Oxygenation: Effective Arterialization of Portal Blood by Hyperoxia (2004) (8)
- Highly selective intraportal transplantation of pancreatic islets. (2009) (7)
- Mesangial matrix-activated monocytes express functional scavenger receptors and accumulate intracellular lipid. (2008) (7)
- Low plasma protein nitrotyrosine levels distinguish primary Raynaud’s phenomenon from scleroderma (2005) (7)
- Effect of donor treatment with heparinoids on graft function after intraportal transplantation of a marginal islet mass: an experimental study. (2003) (7)
- Restoring and extending secondary prevention (2023) (6)
- 31-Phosphorus magnetic resonance spectroscopy for dynamic assessment of adenosine triphosphate levels in pancreas preserved by the two-layer method. (2011) (6)
- Lessons from an age-old war (1998) (6)
- Functional and genetic evidence for a role of a non HLA gene (the S-gene) within the MHC in psoriasis. (1999) (5)
- Health outcomes of children born to mothers with chronic kidney disease: a pilot study (2010) (5)
- Surviving native beta-cells determine outcome of syngeneic intraportal islet transplantation. (2001) (5)
- Surviving Native β-Cells Determine Outcome of Syngeneic Intraportal Islet Transplantation (2001) (5)
- FK506 and CsA differ in their effect on intracellular cytokine expression following kidney transplantation. (2001) (5)
- Isolation and ordering of HLA class I region cosmids. (1996) (4)
- NO ADDITIONAL ROLE FOR THE MHC CLASS-II ENCODED COMPONENTS OF THE HLA CLASS-I PATHWAY OF ANTIGEN PRESENTATION (LMP2, TAP1-AND-2) IN THE ETIOLOGY OF ANKYLOSING-SPONDYLITIS (AS) (1993) (4)
- Identification of new HLA class I region genes by sample sequencing (1996) (3)
- Compassion: a leadership imperative for health systems (2017) (3)
- Interpreting regulatory authority guidance on immunosuppressive therapy for renal transplantation: a response to the UK's National Institute for Clinical Excellence (NICE). (2008) (3)
- An improved method of fluorescent dual insulin and endothelial staining allows visualisation of the revascularisation of intraportally transplanted islets. (2005) (2)
- Welcome to BMJ Leader (2017) (2)
- omega 3 Polyunsaturated fatty acids (PUFA) inhibit NF-kappa B activity in LPS-Stimulated proximal tubular cells by PPAR gamma activation. (2003) (1)
- Dialysis induces cyclosporine a resistance: induction therapy with bolus ATG-Fresenius increases cyclosporine sensistivity. (2003) (1)
- ORGANIZATION AND FUNCTIONS OF THE CLASS-II REGION OF THE HUMAN MHC (1994) (1)
- Looking to the future of clinical leadership (2017) (1)
- Typing alleles of TAP1 and TAP2. (2003) (1)
- Tubular and glomerular proteinuria as markers of occult renal involvement in systemic sclerosis. (2003) (1)
- Human mesangial matrix stimulates production of inflammatory cytokines and induces scavenger receptor expression in THP-1 monocytes. (2002) (0)
- Sample sequencing of the human major histocompatibility complex class I region identifies further new genes (2000) (0)
- Mesangial matrix‐activated mononuclear cells express functional scavenger receptors and accumulate intracellular lipid (2003) (0)
- WO14-OR-6 SCAP-MEDIATED DYSREGULATION OF LDL RECEPTOR UNDER INFLAMMATORY STRESS: A POTENTIAL NEW PATHWAY FOR FOAM CELL FORMATION (2007) (0)
- Inflammation both exacerbates arterial injury and lowers blood lipid levels in an animal model of atherosclerosis (2007) (0)
- Cardiovascular complications - 2 (2009) (0)
- Long-and short-term outcomes in renal allografts with deceased donors : A (2018) (0)
- Characterisation of the s-gene as a candidate for psoriasis susceptibility (1999) (0)
- Sirolimus affects liver cell cholesterol homeostasis: Potential molecular mechanisms for sirolimus-associated dyslipidaemia (2007) (0)
- Identification of new genes within the MHC susceptibility region for psoriasis (2000) (0)
- Genetic Risk Variants for Membranous Nephropathy : Extension and Association with Other CKD Etiologies (2017) (0)
- PO1-9 A COMPARATIVE STUDY OF DYSREGULATION OF LOW-DENSITY LIPOPROTEIN RECEPTOR FEEDBACK REGULATION IN HEPG2 AND HUMAN MESANGIAL CELLS BY INFLAMMATORY CYTOKINES (2007) (0)
- Psoriasis susceptibility: Characterization of potential new candidate genes (2000) (0)
- Identification of new HLA class I region genes. (1997) (0)
- A proteaasome-related gene between the two ABC transporter loci in the class II region of the human MHC (1991) (0)
- The NHS at 70 (2018) (0)
- Modulation of MHC antigen expression and disease: edited by G.E. Blair, C.R. Pringle and D.J. Maudsley, Cambridge University Press, 1995. £50.00 (xviii + 440 pages) ISBN 0 521 49578 4 (1996) (0)
- Inflammation causes statin resistance: A potential mechanism for ineffectiveness of statin therapy in patients with chronic inflammation (2007) (0)
- Anti-idiotypic antibody regulation of anti-HLA antibodies in renal dialysis patients (1997) (0)
- Introducing ‘Nephron Clinical Guidelines’ (2008) (0)
- CYTOKINE GENE POLYMORPHISM MAY PREDICT REJECTION FOLLOWING RENAL TRANSPLANTATION.: Abstract# 411 Poster Board #‐Session: P51‐II (2000) (0)
- Patient characteristics and outcomes in a cohort of biosy proven cases of Scleroderma renal crisis (SRC) (2001) (0)
- Moving to the enlightened side: how did I end up here? (2018) (0)
- Platelet-activating factor (PAF) increases the expression of LDL and scavenger receptors and activates NF-kappa B in human mesangial cells (HMC) (2002) (0)
- Halting Chronic Allograft Nephropathy – Do We Already Have the Drugs? (2003) (0)
- HLA analysis of IgA deficiency in Sardinians (1996) (0)
- Characterisation of the MHC-linked psoriasis susceptibility locus in Gujarati indians (2002) (0)
- Anti-atherosclerotic effects of sirolimus: Dual actions on both cholesterol Homeostasis and inflammmation. (2003) (0)
- MICA allele mismatching, MICA antibodies and rejection in renal transplantation (2010) (0)
- EFFECT OF INSPIRED OXYGEN CONCENTRATION ON THE OUTCOME OF SYNGENEIC INTRAPORTAL ISLET TRANSPLANTATION.: Abstract# 945 Poster Board #‐Session: P202‐III (2000) (0)
- 58. 19F-MRI and headspace gas chromatography to determine penetration of perfluorocarbon in pancreas preserved by two-layer method for islet transplantation (2007) (0)
- The genetic architecture of membranous nephropathy and its potential to improve non-invasive diagnosis (2020) (0)
- Immunological status in two siblings with a peptide transporter deficiency (1994) (0)
- Structural organization of chromosome 6 in interphase. (1997) (0)
- Linkage disequilibruim (LD) domain mapping identifies PSORS1 candidate regions for psoriasis susceptibility. (2001) (0)
- Treatment of malnutrition and anaemia (2011) (0)
- ANTIGEN-PROCESSING GENES IN THE HUMAN MHC (1994) (0)
- Out of darkness and into enlightenment (2017) (0)
- Contents Vol. 107, 2007 (2008) (0)
- Total pancreatectomy and pancreatic islet autotransplantation in patient with intractable pain caused by chronic pancreatitis (2010) (0)
- FK506 and CsA have a different effect on intracellular cytokine (Th1 and Th2) expression following kidney transplantation (2000) (0)
- Inherited homozygous TAP2 peptide transporter defect in two siblings with HLA class I deficiency (1994) (0)
- ANALYSIS OF CYTOKINE PRODUCING T CELLS FOLLOWING RENAL TRANSPLANTATION MAY PREDICT CHRONIC REJECTION.: Abstract# 435 Poster Board #‐Session: P75‐II (2000) (0)
- COVID-19 models and expectations – Learning from the pandemic (2022) (0)
- RHEUMATOID-ARTHRITIS IS NOT PRIMARILY ASSOCIATED WITH A VARIANT OF THE TAP-2 GENE (1993) (0)
- Changes in portal blood flow and liver oxygenation following intraportal injection of pancreatic islet-sized dextran beads (2007) (0)
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