Stephen S. Hecht

Q: What Schools Are Affiliated With Stephen S. Hecht

Stephen S. Hecht is affiliated with the following schools: University of California, Berkeley, McGill University, University of Minnesota, University of Kaiserslautern-Landau, Pennsylvania State University, University of São Paulo, Moldova State University

Stephen S. Hecht's AcademicInfluence.com Rankings

Stephen S. Hecht

Law

#841

World Rank

#1099

Historical Rank

Common Law

World Rank

Historical Rank

International Law

#63

World Rank

#92

Historical Rank

law Degrees

Stephen S. Hecht

Chemistry

#708

World Rank

#1199

Historical Rank

chemistry Degrees

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Law
Chemistry

Stephen S. Hecht's Degrees

PhD Chemistry University of California, Berkeley
Bachelors Chemistry University of California, Berkeley

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Stephen S. Hecht's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Tobacco smoke carcinogens and lung cancer. (1999) (1935)
Tobacco smoke and involuntary smoking. (2004) (1624)
Tobacco carcinogens, their biomarkers and tobacco-induced cancer (2003) (1134)
Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosamines. (1998) (1059)
Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers (2002) (1030)
Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1. (1996) (832)
Tobacco-specific nitrosamines, an important group of carcinogens in tobacco and tobacco smoke. (1988) (713)
Environmental and chemical carcinogenesis. (2004) (602)
Smokeless tobacco and cancer. (2008) (600)
Cigarette smoking and lung cancer: chemical mechanisms and approaches to prevention. (2002) (526)
INHIBITION OF CARCINOGENESIS BY ISOTHIOCYANATES* (2000) (432)
Human urinary carcinogen metabolites: biomarkers for investigating tobacco and cancer. (2002) (397)
Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis (2015) (382)
Lung carcinogenesis by tobacco smoke (2012) (381)
DNA adduct formation from tobacco-specific N-nitrosamines. (1999) (356)
Induction of lung and exocrine pancreas tumors in F344 rats by tobacco-specific and Areca-derived N-nitrosamines. (1988) (343)
Nicotine-derived N-nitrosamines and tobacco-related cancer: current status and future directions. (1985) (342)
Chemoprevention of cancer by isothiocyanates, modifiers of carcinogen metabolism. (1999) (296)
Formation of cyclic 1,N2-propanodeoxyguanosine adducts in DNA upon reaction with acrolein or crotonaldehyde. (1984) (293)
Comparison of Nicotine and Toxicant Exposure in Users of Electronic Cigarettes and Combustible Cigarettes (2018) (291)
Effects of Glucosinolate-Rich Broccoli Sprouts on Urinary Levels of Aflatoxin-DNA Adducts and Phenanthrene Tetraols in a Randomized Clinical Trial in He Zuo Township, Qidong, People's Republic of China (2005) (283)
Chemoprevention by isothiocyanates (1995) (277)
The relevance of tobacco-specific nitrosamines to human cancer. (1989) (266)
Progress and challenges in selected areas of tobacco carcinogenesis. (2008) (261)
New and traditional smokeless tobacco: comparison of toxicant and carcinogen levels. (2008) (242)
Quantitation of urinary metabolites of a tobacco-specific lung carcinogen after smoking cessation. (1999) (242)
Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice. (2005) (233)
Tobacco carcinogens, their biomarkers and tobacco-induced cancer (2004) (229)
Cigarette smoking: cancer risks, carcinogens, and mechanisms (2006) (227)
Advances in Tobacco Carcinogenesis (1990) (224)
Mandated lowering of toxicants in cigarette smoke: a description of the World Health Organization TobReg proposal (2008) (220)
Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA adduct formation and tumorigenicity in the lung of F344 rats by dietary phenethyl isothiocyanate. (1989) (213)
Reduced nicotine content cigarettes: effects on toxicant exposure, dependence and cessation. (2010) (211)
Assessing secondhand smoke using biological markers (2012) (210)
Tobacco smoke carcinogens and breast cancer (2002) (210)
Biochemical Verification of Tobacco Use and Abstinence: 2019 Update. (2019) (210)
Randomized Trial of Reduced-Nicotine Standards for Cigarettes. (2015) (207)
Evaluation of toxicant and carcinogen metabolites in the urine of e-cigarette users versus cigarette smokers. (2015) (207)
A tobacco-specific lung carcinogen in the urine of men exposed to cigarette smoke. (1993) (207)
Identification of DNA adducts of acetaldehyde. (2000) (205)
Effects of aromatic isothiocyanates on tumorigenicity, O6-methylguanine formation, and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung. (1989) (202)
Smokers with the CHRNA lung cancer-associated variants are exposed to higher levels of nicotine equivalents and a carcinogenic tobacco-specific nitrosamine. (2008) (194)
O6-methylguanine is a critical determinant of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone tumorigenesis in A/J mouse lung. (1991) (192)
Induction of oral cavity tumors in F344 rats by tobacco-specific nitrosamines and snuff. (1986) (190)
Approaches to Cancer Prevention Based on an Understanding of N-Nitrosamine Carcinogenesis (1997) (188)
Essential role of p53 in phenethyl isothiocyanate-induced apoptosis. (1998) (185)
Anthocyanins in Black Raspberries Prevent Esophageal Tumors in Rats (2009) (184)
The reemergence of smokeless tobacco. (1986) (179)
Cancer prevention with freeze-dried berries and berry components. (2007) (170)
Effects of watercress consumption on metabolism of a tobacco-specific lung carcinogen in smokers. (1995) (170)
Analysis of DNA and protein adducts of benzo[a]pyrene in human tissues using structure-specific methods. (2003) (169)
Evaluation of butylated hydroxyanisole, myo-inositol, curcumin, esculetin, resveratrol and lycopene as inhibitors of benzo[a]pyrene plus 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in A/J mice. (1999) (164)
G to A transitions and G to T transversions in codon 12 of the Ki-ras oncogene isolated from mouse lung tumors induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and related DNA methylating and pyridyloxobutylating agents. (1993) (159)
Comparative carcinogenicity in F344 rats of the tobacco-specific nitrosamines, N'-nitrosonornicotine and 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone. (1980) (158)
Rapid single-dose model for lung tumor induction in A/J mice by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and the effect of diet. (1989) (158)
Effects of smoking cessation on eight urinary tobacco carcinogen and toxicant biomarkers. (2009) (158)
Cytochrome P450 enzymes as catalysts of metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco specific carcinogen. (2005) (156)
Tobacco-specific nitrosamines: formation from nicotine in vitro and during tobacco curing and carcinogenicity in strain A mice. (1978) (153)
Comparative carcinogenicity in A/J mice and metabolism by cultured mouse peripheral lung of N'-nitrosonornicotine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, and their analogues. (1983) (152)
Tobacco-specific nitrosamines in new tobacco products. (2006) (152)
2'-Hydroxylation of nicotine by cytochrome P450 2A6 and human liver microsomes: formation of a lung carcinogen precursor. (2000) (150)
Transport of the β-O-Glucuronide Conjugate of the Tobacco-specific Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by the Multidrug Resistance Protein 1 (MRP1) (2001) (150)
Structure-activity relationships for inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone lung tumorigenesis by arylalkyl isothiocyanates in A/J mice. (1991) (149)
Metabolites of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in smokers' urine. (1993) (149)
Intraindividual and interindividual differences in metabolites of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in smokers' urine. (1995) (145)
Assessment of tobacco-specific N-nitrosamines in tobacco products. (1979) (145)
GRAS flavoring substances 25 (2001) (145)
Comparative tumorigenicity and DNA methylation in F344 rats by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N-nitrosodimethylamine. (1986) (144)
Rapid and Sustainable Detoxication of Airborne Pollutants by Broccoli Sprout Beverage: Results of a Randomized Clinical Trial in China (2014) (143)
Relationships between Cigarette Consumption and Biomarkers of Tobacco Toxin Exposure (2005) (143)
Induction of liver tumors in F344 rats by crotonaldehyde. (1986) (137)
Urinary levels of tobacco-specific nitrosamine metabolites in relation to lung cancer development in two prospective cohorts of cigarette smokers. (2009) (137)
Metabolites of a tobacco-specific carcinogen in urine from newborns. (1999) (137)
Metabolism in the F344 rat of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco-specific carcinogen. (1980) (136)
Quantitation of acrolein-derived (3-hydroxypropyl)mercapturic acid in human urine by liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry: effects of cigarette smoking. (2007) (135)
Similar Uptake of Lung Carcinogens by Smokers of Regular, Light, and Ultralight Cigarettes (2005) (132)
Differences in the urinary metabolites of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in black and white smokers. (1997) (131)
Reactions of formaldehyde plus acetaldehyde with deoxyguanosine and DNA: formation of cyclic deoxyguanosine adducts and formaldehyde cross-links. (2003) (131)
Mass spectrometric analysis of tobacco-specific nitrosamine-DNA adducts in smokers and nonsmokers. (1991) (127)
Chrysene and methylchrysenes: presence in tobacco smoke and carcinogenicity. (1974) (127)
Research opportunities related to establishing standards for tobacco products under the Family Smoking Prevention and Tobacco Control Act. (2012) (123)
Evaluation of carcinogen exposure in people who used "reduced exposure" tobacco products. (2004) (123)
The biological significance of tobacco-specific N-nitrosamines: smoking and adenocarcinoma of the lung. (1996) (122)
Tobacco-Specific Nitrosamines and Their Pyridine-N-glucuronides in the Urine of Smokers and Smokeless Tobacco Users (2005) (121)
Effects of watercress consumption on urinary metabolites of nicotine in smokers. (1999) (120)
A Prospectively Measured Serum Biomarker for a Tobacco-Specific Carcinogen and Lung Cancer in Smokers (2009) (119)
Effects of alkyl chain length on the inhibition of NNK-induced lung neoplasia in A/J mice by arylalkyl isothiocyanates. (1989) (118)
Identification of cis-2-butene-1,4-dial as a microsomal metabolite of furan. (1995) (116)
Identification of an acetaldehyde adduct in human liver DNA and quantitation as N2-ethyldeoxyguanosine. (2006) (115)
Recent studies on mechanisms of bioactivation and detoxification of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific lung carcinogen. (1996) (115)
Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China. (2012) (114)
Metabolism of tobacco-specific N-nitrosamines by cultured human tissues. (1983) (112)
Tobacco addiction: implications for treatment and cancer prevention. (1997) (112)
Metabolites of a tobacco-specific lung carcinogen in nonsmoking women exposed to environmental tobacco smoke. (2001) (110)
A review: dietary and endogenously formed N-nitroso compounds and risk of childhood brain tumors (2005) (110)
Evidence for 4-(3-pyridyl)-4-oxobutylation of DNA in F344 rats treated with the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N'-nitrosonornicotine. (1988) (110)
Formaldehyde and leukemia: Epidemiology, potential mechanisms, and implications for risk assessment (2009) (109)
Biomarkers to assess the utility of potential reduced exposure tobacco products. (2006) (109)
Mass spectrometric analysis of tobacco-specific nitrosamine hemoglobin adducts in snuff dippers, smokers, and nonsmokers. (1990) (108)
Effects of reduced cigarette smoking on the uptake of a tobacco-specific lung carcinogen. (2004) (108)
Changing smokeless tobacco products new tobacco-delivery systems. (2007) (108)
Metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in the patas monkey: pharmacokinetics and characterization of glucuronide metabolites. (1993) (108)
Similar Exposure to a Tobacco-Specific Carcinogen in Smokeless Tobacco Users and Cigarette Smokers (2007) (107)
Comparative tumorigenicity of benzo[a]pyrene, 1-nitropyrene and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine administered by gavage to female CD rats. (1995) (106)
Nicotine Metabolite Ratio Predicts Smoking Topography and Carcinogen Biomarker Level (2011) (105)
Inositol hexaphosphate inhibits cell transformation and activator protein 1 activation by targeting phosphatidylinositol-3' kinase. (1997) (104)
Comparative tumor initiating activity on mouse skin of 6-nitrobenzo[a]pyrene, 6-nitrochrysene, 3-nitroperylene, 1-nitropyrene and their parent hydrocarbons. (1982) (104)
Tobacco‐specific nitrosamines in smokeless tobacco products marketed in India (2005) (103)
Effects of α-deuterium substitution on the mutagenicity of 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK)1 (1983) (102)
Identification and mutagenicity of metabolites of 1-nitropyrene formed by rat liver. (1983) (102)
Characterization of amino acid and glutathione adducts of cis-2-butene-1,4-dial, a reactive metabolite of furan. (1997) (101)
Comparative carcinogenicity and metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N'-nitrosonornicotine in Syrian golden hamsters. (1981) (101)
Urinary levels of cigarette smoke constituent metabolites are prospectively associated with lung cancer development in smokers. (2011) (100)
Exposure and Metabolic Activation Biomarkers of Carcinogenic Tobacco-Specific Nitrosamines. (2016) (99)
Complete inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced rat lung tumorigenesis and favorable modification of biomarkers by phenethyl isothiocyanate. (1996) (98)
Cytochrome P450 2A-catalyzed metabolic activation of structurally similar carcinogenic nitrosamines: N'-nitrosonornicotine enantiomers, N-nitrosopiperidine, and N-nitrosopyrrolidine. (2005) (98)
Lung tumor induction in A/J mice by the tobacco smoke carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene: a potentially useful model for evaluation of chemopreventive agents. (1994) (98)
Effects of dietary indoles and isothiocyanates on N-nitrosodimethylamine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone alpha-hydroxylation and DNA methylation in rat liver. (1985) (98)
Metabolites of a tobacco-specific lung carcinogen in the urine of elementary school-aged children. (2001) (97)
Pyridyloxobutyl adduct O6-[4-oxo-4-(3-pyridyl)butyl]guanine is present in 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone-treated DNA and is a substrate for O6-alkylguanine-DNA alkyltransferase. (1997) (95)
NIH electronic cigarette workshop: developing a research agenda. (2015) (95)
Carcinogenicity studies of inhaled cigarette smoke in laboratory animals: old and new. (2005) (94)
Detection and quantitation of acrolein-derived 1,N2-propanodeoxyguanosine adducts in human lung by liquid chromatography-electrospray ionization-tandem mass spectrometry. (2007) (94)
Chemoprevention of Esophageal Cancer with Black Raspberries, Their Component Anthocyanins, and a Major Anthocyanin Metabolite, Protocatechuic Acid (2014) (93)
Genotoxicity of acetaldehyde- and crotonaldehyde-induced 1,N2-propanodeoxyguanosine DNA adducts in human cells. (2006) (92)
Applying tobacco carcinogen and toxicant biomarkers in product regulation and cancer prevention. (2010) (91)
Identification of adducts formed by pyridyloxobutylation of deoxyguanosine and DNA by 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone, a chemically activated form of tobacco specific carcinogens. (2003) (91)
Effect of Immediate vs Gradual Reduction in Nicotine Content of Cigarettes on Biomarkers of Smoke Exposure: A Randomized Clinical Trial (2018) (91)
Dose-response study of DNA and hemoglobin adduct formation by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in F344 rats. (1990) (91)
Nicotine Metabolism in Three Ethnic/Racial Groups with Different Risks of Lung Cancer (2008) (90)
High-performance liquid chromatography-based determination of total isothiocyanate levels in human plasma: application to studies with 2-phenethyl isothiocyanate. (2001) (90)
Differential effect of chronic ethanol consumption on the carcinogenicity of N-nitrosopyrrolidine and N'-nitrosonornicotine in male Syrian golden hamsters. (1981) (89)
Analysis of 23 polycyclic aromatic hydrocarbons in smokeless tobacco by gas chromatography-mass spectrometry. (2010) (87)
A study of tobacco carcinogenesis. XIV. Effects of N'-nitrosonornicotine and N'-nitrosonanabasine in rats. (1975) (87)
Formation and accumulation of pyridyloxobutyl DNA adducts in F344 rats chronically treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol. (2007) (86)
Chemoprevention of lung carcinogenesis in addicted smokers and ex-smokers (2009) (86)
Cabbage Yield and Glucosinolate Concentrations as Affected by Nitrogen and Sulfur Fertility (2005) (84)
Analysis of total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in human urine. (2003) (83)
Tumorigenicity and metabolism of 1-nitropyrene in A/J mice. (1984) (83)
Tumorigenicity and metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol enantiomers and metabolites in the A/J mouse. (1999) (82)
Identification of cyanidin glycosides as constituents of freeze-dried black raspberries which inhibit anti-benzo[a]pyrene-7,8-diol-9,10-epoxide induced NFkappaB and AP-1 activity. (2005) (81)
Urinary levels of the tobacco-specific carcinogen N'-nitrosonornicotine and its glucuronide are strongly associated with esophageal cancer risk in smokers. (2011) (81)
Formation of cyclic 1,N2--adducts by reaction of deoxyguanosine with alpha-acetoxy-N-nitrosopyrrolidine, 4-(carbethoxynitrosamino)butanal, or crotonaldehyde. (1983) (81)
Mammary carcinogenicity in female CD rats of fjord region diol epoxides of benzo[c]phenanthrene, benzo[g]chrysene and dibenzo[a,l]pyrene. (1995) (80)
Carcinogen derived biomarkers: applications in studies of human exposure to secondhand tobacco smoke (2004) (80)
Benzyl isothiocyanate: an effective inhibitor of polycyclic aromatic hydrocarbon tumorigenesis in A/J mouse lung. (2002) (80)
Metabolic activation and detoxification of tobacco-specific nitrosamines--a model for cancer prevention strategies. (1994) (79)
r-1,t-2,3,c-4-Tetrahydroxy-1,2,3,4-tetrahydrophenanthrene in human urine: a potential biomarker for assessing polycyclic aromatic hydrocarbon metabolic activation. (2003) (79)
Induction of respiratory tract tumors in Syrian golden hamsters by a single dose of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and the effect of smoke inhalation. (1983) (78)
A metabolite of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in the urine of hospital workers exposed to environmental tobacco smoke. (1998) (78)
Quantitation of pyridyloxobutyl DNA adducts of tobacco-specific nitrosamines in rat tissue DNA by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry. (2006) (78)
Aspartame consumption in relation to childhood brain tumor risk: results from a case-control study. (1997) (77)
Chemical studies on tobacco smoke. XXXIII. N' -nitrosonornicotine in tobacco: analysis of possible contributing factors and biologic implications. (1975) (77)
Nicotine-derived N-nitrosamines (TSNA) and their relevance in tobacco carcinogenesis. (1991) (77)
New DNA adducts of crotonaldehyde and acetaldehyde. (2001) (76)
Inhibition of lung tumorigenesis in A/J mice by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-L-cysteine and myo-inositol, individually and in combination. (2002) (76)
Chemical Studies on Tobacco Smoke: LI: Studies on Non-Volatile Nitrosamines in Tobacco (1977) (76)
A study of tobacco carcinogenesis. XX. Role of catechol as a major cocarcinogen in the weakly acidic fraction of smoke condensate. (1981) (76)
Biomarkers of exposure to new and emerging tobacco delivery products. (2017) (76)
Effects of isothiocyanates on tumorigenesis by benzo[a]pyrene in murine tumor models. (1993) (74)
Evidence for an important role of DNA pyridyloxobutylation in rat lung carcinogenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: effects of dose and phenethyl isothiocyanate. (1997) (74)
Effects of chronic ethanol consumption on the metabolism and carcinogenicity of N'-nitrosonornicotine in F344 rats. (1984) (73)
Comparative metabolism of the tobacco-related carcinogens benzo[a]pyrene, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, and N'- nitrosonornicotine in human hepatic microsomes. (1997) (73)
Reduced Nicotine Content Cigarettes and Nicotine Patch (2013) (72)
Formation and analysis of N-nitrosamines in tobacco products and their endogenous formation in consumers. (1984) (72)
Dose-response study of the carcinogenicity of tobacco-specific N-nitrosamines in F344 rats (2004) (72)
Analysis of crotonaldehyde- and acetaldehyde-derived 1,n(2)-propanodeoxyguanosine adducts in DNA from human tissues using liquid chromatography electrospray ionization tandem mass spectrometry. (2006) (72)
Formation of hemoglobin adducts upon treatment of F344 rats with the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N'-nitrosonornicotine. (1987) (71)
Analysis of pyridyloxobutyl DNA adducts in F344 rats chronically treated with (R)- and (S)-N'-nitrosonornicotine. (2007) (70)
Tumorigenicity in newborn mice of fjord region and other sterically hindered diol epoxides of benzo[g]chrysene, dibenzo[a,l]pyrene (dibenzo[def,p]chrysene), 4H-cyclopenta[def]chrysene and fluoranthene. (1995) (70)
High throughput liquid and gas chromatography-tandem mass spectrometry assays for tobacco-specific nitrosamine and polycyclic aromatic hydrocarbon metabolites associated with lung cancer in smokers. (2013) (70)
Effects of phenethyl isothiocyanate and benzyl isothiocyanate, individually and in combination, on lung tumorigenesis induced in A/J mice by benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. (2000) (69)
Analysis of phenanthrene and benzo[a]pyrene tetraol enantiomers in human urine: relevance to the bay region diol epoxide hypothesis of benzo[a]pyrene carcinogenesis and to biomarker studies. (2010) (69)
Analysis of N- and O-glucuronides of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in human urine. (2002) (69)
Tobacco-specific nitrosamine adducts: studies in laboratory animals and humans. (1993) (69)
Carcinogen biomarkers related to smoking and upper aerodigestive tract cancer (1993) (68)
Quantitation of an acetaldehyde adduct in human leukocyte DNA and the effect of smoking cessation. (2007) (68)
Quantitation of metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone after cessation of smokeless tobacco use. (2002) (68)
Indole-3-carbinol inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo(a)pyrene-induced lung tumorigenesis in A/J mice and modulates carcinogen-induced alterations in protein levels. (2007) (68)
Presence of the carcinogen N'-nitrosonornicotine in the urine of some users of oral nicotine replacement therapy products. (2009) (67)
Effects of dietary compounds on alpha-hydroxylation of N-nitrosopyrrolidine and N'-nitrosonornicotine in rat target tissues. (1984) (66)
Analysis of human urine for pyridine-N-oxide metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco-specific lung carcinogen. (1997) (66)
Approaches to chemoprevention of lung cancer based on carcinogens in tobacco smoke. (1997) (65)
Evaluation of the transplacental tumorigenicity of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mice. (1989) (64)
The role of intestinal microflora in the metabolic reduction of 1-nitropyrene to 1-aminopyrene in conventional and germfree rats and in humans. (1983) (64)
Pyridyloxobutyl DNA adducts inhibit the repair of O6-methylguanine. (1993) (64)
N-nitroso compounds and man: sources of exposure, endogenous formation and occurrence in body fluids. (1998) (64)
Research on cruciferous vegetables, indole-3-carbinol, and cancer prevention: A tribute to Lee W. Wattenberg. (2016) (63)
Urinary tobacco smoke-constituent biomarkers for assessing risk of lung cancer. (2014) (62)
(S)-N'-Nitrosonornicotine, a constituent of smokeless tobacco, is a powerful oral cavity carcinogen in rats. (2013) (62)
Chemoprevention of lung cancer by isothiocyanates. (1996) (62)
Metabolic α-Hydroxylation of the Tobacco-specific Carcinogen, N′-Nitrosonornicotine (1978) (62)
Metabolism of tobacco-specific nitrosamines by cultured rat nasal mucosa. (1983) (61)
1,2-dihydro-1,2-dihydroxy-5-methylchrysene, a major activated metabolite of the environmental carcinogen 5-methylchrysene. (1978) (61)
Identification of O2-substituted pyrimidine adducts formed in reactions of 4-(acetoxymethylnitrosamino)- 1-(3-pyridyl)-1-butanone and 4-(acetoxymethylnitros- amino)-1-(3-pyridyl)-1-butanol with DNA. (2004) (61)
Reaction of nicotine and sodium nitrite: formation of nitrosamines and fragmentation of the pyrrolidine ring. (1978) (61)
Application of a High-Resolution Mass-Spectrometry-Based DNA Adductomics Approach for Identification of DNA Adducts in Complex Mixtures (2014) (61)
Effects of cruciferous vegetable consumption on urinary metabolites of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in singapore chinese. (2004) (61)
Kinetics of DNA Adduct Formation in the Oral Cavity after Drinking Alcohol (2012) (61)
Tobacco and Cancer: Approaches Using Carcinogen Biomarkers and Chemoprevention (1997) (60)
Clear differences in levels of a formaldehyde-DNA adduct in leukocytes of smokers and nonsmokers. (2009) (60)
Effects of benzyl isothiocyanate and 2-phenethyl isothiocyanate on benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism in F-344 rats. (2003) (60)
Metabolites of a Tobacco-Specific Lung Carcinogen in Children Exposed to Secondhand or Thirdhand Tobacco Smoke in Their Homes (2011) (59)
Mass spectrometric analysis of relative levels of pyridyloxobutylation adducts formed in the reaction of DNA with a chemically activated form of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. (2005) (58)
Evidence for Metabolic α Hydroxylation of N -Nitrosopyrrolidine (1978) (58)
Children's exposure to environmental tobacco smoke: using diverse exposure metrics to document ethnic/racial differences. (2003) (58)
Children's exposure to secondhand and thirdhand smoke carcinogens and toxicants in homes of hookah smokers. (2014) (57)
Analysis of acrolein-derived 1,N2-propanodeoxyguanosine adducts in human leukocyte DNA from smokers and nonsmokers. (2011) (57)
Inhibition of N'-nitrosonornicotine-induced esophageal tumorigenesis by 3-phenylpropyl isothiocyanate. (1998) (57)
4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol and its Glucuronides in the Urine of Infants Exposed to Environmental Tobacco Smoke (2006) (57)
Clinical Trial of 2-Phenethyl Isothiocyanate as an Inhibitor of Metabolic Activation of a Tobacco-Specific Lung Carcinogen in Cigarette Smokers (2016) (57)
Evidence for endogenous formation of N'-nitrosonornicotine in some long-term nicotine patch users. (2009) (57)
The roles of tobacco, alcohol, and diet in the etiology of upper alimentary and respiratory tract cancers. (1980) (56)
Racial/Ethnic Differences in Lung Cancer Incidence in the Multiethnic Cohort Study: An Update. (2019) (56)
Detection of cyclic 1,N2-propanodeoxyguanosine adducts in DNA of rats treated with N-nitrosopyrrolidine and mice treated with crotonaldehyde. (1989) (56)
Origin in tobacco smoke of N'-nitrosonornicotine, a tobacco-specific carcinogen. (1977) (56)
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Extensive Metabolic Activation of the Tobacco-Specific Carcinogen 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone in Smokers (2008) (55)
Enhanced metabolism and mutagenesis of nitrosopyrrolidine in liver fractions isolated from chronic ethanol-consuming hamsters. (1979) (55)
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Tissue distribution of the tobacco-specific carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and its metabolites in F344 rats. (1983) (54)
Quantitation of 4-oxo-4-(3-pyridyl)butanoic acid and enantiomers of 4-hydroxy-4-(3-pyridyl)butanoic acid in human urine: A substantial pathway of nicotine metabolism. (1999) (54)
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Metabolites of a tobacco-specific nitrosamine, 4-(methylnitrosamino)- 1-(3-pyridyl)-1-butanone (NNK), in the urine of smokeless tobacco users: relationship between urinary biomarkers and oral leukoplakia. (1996) (53)
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Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone tumorigenicity in mouse lung by the synthetic organoselenium compound, 1,4-phenylenebis(methylene)selenocyanate. (1993) (49)
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A tobacco‐specific carcinogen in the fetus (2000) (48)
Tobacco‐specific N‐nitrosamine exposures and cancer risk in the Shanghai cohort study: Remarkable coherence with rat tumor sites (2014) (48)
Evaluation of 32P-postlabeling analysis of DNA from exfoliated oral mucosa cells as a means of monitoring exposure of the oral cavity to genotoxic agents. (1989) (48)
Analysis of faeces for benzo[a]pyrene after consumption of charcoal-broiled beef by rats and humans. (1979) (48)
Analysis of pyridyloxobutyl and pyridylhydroxybutyl DNA adducts in extrahepatic tissues of F344 rats treated chronically with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol. (2009) (48)
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Quantitation of pyridylhydroxybutyl-DNA adducts in liver and lung of F-344 rats treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol. (2008) (47)
Evidence supporting the role of DNA pyridyloxobutylation in rat nasal carcinogenesis by tobacco-specific nitrosamines. (1994) (47)
Comparison of Polymorphisms in Genes Involved in Polycyclic Aromatic Hydrocarbon Metabolism with Urinary Phenanthrene Metabolite Ratios in Smokers (2006) (47)
Longitudinal Study of Urinary Phenanthrene Metabolite Ratios: Effect of Smoking on the Diol Epoxide Pathway (2005) (47)
Comprehensive analysis of urinary metabolites of N'-nitrosonornicotine. (1981) (47)
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Quantitation of microsomal alpha-hydroxylation of the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. (1991) (47)
Dietary Consumption of Black Raspberries or Their Anthocyanin Constituents Alters Innate Immune Cell Trafficking in Esophageal Cancer (2015) (46)
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Mass Spectrometric Quantitation of Nicotine, Cotinine, and 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in Human Toenails (2006) (46)
Tobacco, e-cigarettes, and child health (2017) (46)
Recent Studies on DNA Adducts Resulting from Human Exposure to Tobacco Smoke (2019) (45)
Metabolic activation of the tobacco carcinogen 4-(methylnitrosamino)-(3-pyridyl)-1-butanone by cytochrome P450 2A13 in human fetal nasal microsomes. (2005) (45)
Effects of dietary sinigrin or indole-3-carbinol on O6-methylguanine-DNA-transmethylase activity and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA methylation and tumorigenicity in F344 rats. (1988) (45)
Analysis of phenanthrols in human urine by gas chromatography-mass spectrometry: potential use in carcinogen metabolite phenotyping. (2004) (45)
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Tumorigenicity of 5-methylchrysene dihydrodiols and dihydrodiol epoxides in newborn mice and on mouse skin. (1985) (45)
A study of tobacco carcinogenesis. XLII. Bioassay in A/J mice of some structural analogues of tobacco-specific nitrosamines. (1988) (44)
Quantitative analysis of catechol and 4-methylcatechol in human urine. (1982) (44)
Formation and metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol enantiomers in vitro in mouse, rat and human tissues. (2000) (44)
It Is Time to Regulate Carcinogenic Tobacco-Specific Nitrosamines in Cigarette Tobacco (2014) (44)
Urinary levels of volatile organic carcinogen and toxicant biomarkers in relation to lung cancer development in smokers. (2012) (44)
Effects of phenethyl isothiocyanate on the tissue distribution of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and metabolites in F344 rats. (1995) (44)
Tumour initiating activity of dihydrodiols of benzo[b]fluoranthene, benzo[j]fluoranthene, and benzo[k]fluoranthene. (1982) (44)
Determination of r-7,t-8,9,c-10-tetrahydroxy-7,8,9, 10-tetrahydrobenzo[a]pyrene in human urine by gas chromatography/negative ion chemical ionization/mass spectrometry. (2000) (44)
Comparative mutagenicity, tumor-initiating activity, carcinogenicity, and in vitro metabolism of fluorinated 5-methylchrysenes. (1979) (43)
A study of tobacco carcinogenesis. XV. Effects of N'-nitrosonornicotine and N'-nitrosoanabasine in Syrian golden hamsters. (1977) (43)
Gastric carcinogenesis: 2-chloro-4-methylthiobutanoic acid, a novel mutagen in salted, pickled Sanma hiraki fish, or similarly treated methionine. (1996) (43)
Effects of anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene on human small airway epithelial cells and the protective effects of myo-inositol. (1999) (43)
Thirdhand tobacco smoke: a tobacco-specific lung carcinogen on surfaces in smokers' homes. (2014) (43)
Effects of long term dietary phenethyl isothiocyanate on the microsomal metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in F344 rats. (1997) (43)
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Carcinogenicity and DNA adduct formation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in F-344 rats. (2014) (42)
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Perinatal metabolism of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in C57BL mice. (1984) (42)
Inhibition of lung carcinogenesis and critical cancer-related signaling pathways by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-l-cysteine, indole-3-carbinol and myo-inositol, alone and in combination. (2010) (42)
Oxadiaziridines, the cyclic form of an azoxy group. Synthesis, valence isomerism, and reactivity (1970) (42)
Comparative Levels of O6-Methylguanine, Pyridyloxobutyl-, and Pyridylhydroxybutyl-DNA Adducts in Lung and Liver of Rats Treated Chronically with the Tobacco-Specific Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (2009) (41)
N-nitroso compounds and tobacco-induced cancers in man. (1991) (41)
Time course of DNA adduct formation in peripheral blood granulocytes and lymphocytes after drinking alcohol. (2012) (41)
Evidence for endogenous formation of tobacco-specific nitrosamines in rats treated with tobacco alkaloids and sodium nitrite. (1997) (40)
Identification of the mutagenic metabolites of fluoranthene, 2-methylfluoranthene, and 3-methylfluoranthene. (1982) (40)
Impact of structural and metabolic variations on the toxicity and carcinogenicity of hydroxy- and alkoxy-substituted allyl- and propenylbenzenes. (2014) (40)
Urinary Metabolites of a Tobacco-Specific Lung Carcinogen in Nonsmoking Hospitality Workers (2005) (40)
Absolute configuration of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol formed metabolically from 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. (2000) (40)
Metabolism of the Tobacco-Specific Carcinogen 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone to Its Biomarker Total NNAL in Smokeless Tobacco Users (2008) (40)
Monitoring tobacco-specific N-nitrosamines and nicotine in novel Marlboro and Camel smokeless tobacco products: findings from Round 1 of the New Product Watch. (2012) (40)
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A Randomized Controlled Trial of Progressively Reduced Nicotine Content Cigarettes on Smoking Behaviors, Biomarkers of Exposure, and Subjective Ratings (2016) (40)
High throughput liquid chromatography-tandem mass spectrometry assay for mercapturic acids of acrolein and crotonaldehyde in cigarette smokers' urine. (2013) (39)
Reduction of tumorigenicity and of dihydrodiol formation by fluorine substitution in the angular rings of dibenzo(a,i)pyrene. (1981) (39)
Comparative carcinogenicity in F344 rats and Syrian golden hamsters of N'-nitrosonornicotine and N'-nitrosonornicotine-1-N-oxide. (1983) (39)
Dose–response study of myo-inositol as an inhibitor of lung tumorigenesis induced in A/J mice by benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (2001) (39)
Identification of adducts produced by the reaction of 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanol with deoxyguanosine and DNA. (2003) (39)
Benzene Uptake in Hookah Smokers and Non-smokers Attending Hookah Social Events: Regulatory Implications (2014) (39)
Synthesis of Fjord region diol epoxides as potential ultimate carcinogens of dibenzo[a,l]pyrene. (1994) (39)
Ethylation and methylation of hemoglobin in smokers and non-smokers. (2002) (39)
Nicotine: a precursor for carcinogens. (1985) (38)
Inhibition of vinyl carbamate-induced pulmonary adenocarcinoma by indole-3-carbinol and myo-inositol in A/J mice. (2010) (38)
32P-postlabeling analysis of 1-nitropyrene-DNA adducts in female Sprague-Dawley rats. (1989) (38)
Improved method for determination of 1-hydroxypyrene in human urine. (2004) (38)
Screening for DNA Alkylation Mono and Cross-Linked Adducts with a Comprehensive LC-MS(3) Adductomic Approach. (2015) (38)
Reduced nicotine content cigarettes and use of alternative nicotine products: exploratory trial (2017) (38)
Safety and Efficacy of Weekly Oral Oltipraz in Chronic Smokers (2005) (37)
Effects of indole-3-carbinol on the metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in smokers. (1997) (37)
Tobacco Smoke Exposure in Nonsmoking Hospitality Workers before and after a State Smoking Ban (2010) (37)
Potential contributions of the tobacco nicotine-derived nitrosamine ketone (NNK) in the pathogenesis of steatohepatitis in a chronic plus binge rat model of alcoholic liver disease. (2015) (37)
Tumor-initiating activity of fluorinated 5-methylchrysenes. (1978) (37)
Liver tumor promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxin is dependent on the aryl hydrocarbon receptor and TNF/IL-1 receptors. (2014) (37)
Nitroarenes : occurrence, metabolism, and biological impact (1990) (37)
Enantiomeric composition of N'-nitrosonornicotine and N'-nitrosoanatabine in tobacco. (2000) (37)
5-Methylchrysene metabolism in mouse epidermis in vivo, diol epoxide--DNA adduct persistence, and diol epoxide reactivity with DNA as potential factors influencing the predominance of 5-methylchrysene-1,2-diol-3,4-epoxide--DNA adducts in mouse epidermis. (1983) (37)
Randomised clinical trial of snus versus medicinal nicotine among smokers interested in product switching (2015) (36)
Evidence Supporting Product Standards for Carcinogens in Smokeless Tobacco Products (2014) (36)
Ultrasensitive High-Resolution Mass Spectrometric Analysis of a DNA Adduct of the Carcinogen Benzo[a]pyrene in Human Lung. (2017) (36)
Smoking and lung cancer—a new role for an old toxicant? (2006) (36)
Relationship of Human Toenail Nicotine, Cotinine, and 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol to Levels of These Biomarkers in Plasma and Urine (2007) (36)
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Detection and Quantitation of N′-Nitrosonornicotine in Human Toenails by Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry (2008) (35)
Metabolic alpha-hydroxylation of N-nitrosomorpholine and 3,3,5,5-tetradeutero-N-nitrosomorpholine in the F344 rat. (1981) (35)
Transport of the b-O-Glucuronide Conjugate of the Tobacco-specific Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by the Multidrug Resistance Protein 1 (MRP1) REQUIREMENT FOR GLUTATHIONE OR A NON-SULFUR-CONTAINING ANALOG* (2001) (35)
In vivo and in vitro persistence of pyridyloxobutyl DNA adducts from 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. (1991) (35)
Elevated Levels of Volatile Organic Carcinogen and Toxicant Biomarkers in Chinese Women Who Regularly Cook at Home (2010) (35)
Solvolysis of model compounds for alpha-hydroxylation of N'-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: evidence for a cyclic oxonium ion intermediate in the alkylation of nucleophiles. (1990) (35)
Dose-Dependent Inhibition of Tobacco Smoke Carcinogen–Induced Lung Tumorigenesis in A/J Mice by Indole-3-Carbinol (2008) (35)
Identification of ring oxidized metabolites of 1-nitropyrene in the feces and urine of germfree F344 rats. (1984) (35)
Quantitation of a minor enantiomer of phenanthrene tetraol in human urine: correlations with levels of overall phenanthrene tetraol, benzo[a]pyrene tetraol, and 1-hydroxypyrene. (2011) (35)
Stereochemistry of metabolites of a tobacco-specific lung carcinogen in smokers' urine. (1999) (35)
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Comparative metabolism of N-nitrosopiperidine and N-nitrosopyrrolidine by rat liver and esophageal microsomes and cytochrome P450 2A3. (2003) (35)
Roles of tobacco cellulose sugars and chlorogenic acid as precursors to catechol in cigarette smoke (1984) (35)
Identification of crotonaldehyde as a hepatic microsomal metabolite formed by alpha-hydroxylation of the carcinogen N-nitrosopyrrolidine. (1988) (35)
Pilot study on lower nitrosamine smokeless tobacco products compared with medicinal nicotine. (2007) (34)
Metabolism of 1-nitro[U-4,5,9,10-14C]pyrene in the F344 rat. (1984) (34)
Metabolism of N'-nitrosonornicotine enantiomers by cultured rat esophagus and in vivo in rats. (2000) (34)
Analysis of Total 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in Smokers' Blood (2005) (34)
Replication-coupled repair of crotonaldehyde/acetaldehyde-induced guanine-guanine interstrand cross-links and their mutagenicity. (2006) (34)
DNA and hemoglobin alkylation by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its major metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in F344 rats. (1988) (34)
Variation in Levels of the Lung Carcinogen NNAL and Its Glucuronides in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer (2014) (34)
Urinary 3,3′-Diindolylmethane: A Biomarker of Glucobrassicin Exposure and Indole-3-Carbinol Uptake in Humans (2013) (34)
Nornicotine nitrosation in saliva and its relation to endogenous synthesis of N'-nitrosonornicotine in humans. (2013) (34)
Quantitation of pyridyloxobutyl DNA adducts in nasal and oral mucosa of rats treated chronically with enantiomers of N'-nitrosonornicotine. (2009) (34)
Chemopreventive Effect of Kava on 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone plus Benzo[a]pyrene–Induced Lung Tumorigenesis in A/J Mice (2007) (34)
Investigations of metabolic precursors to hemoglobin and DNA adducts of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. (1990) (34)
Determination of N'-nitrosonornicotine in tobacco by high speed liquid chromatography. (1975) (34)
Analysis of 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB)-releasing DNA adducts in human exfoliated oral mucosa cells by liquid chromatography-electrospray ionization-tandem mass spectrometry. (2013) (34)
Quantitation of pyridyloxobutyl-DNA adducts in tissues of rats treated chronically with (R)- or (S)-N'-nitrosonornicotine (NNN) in a carcinogenicity study. (2013) (34)
Metabolism of 5-methylchrysene and 6-methylchrysene by human hepatic and pulmonary cytochrome P450 enzymes. (1996) (33)
Tobacco smoke biomarkers and cancer risk among male smokers in the Shanghai cohort study. (2013) (33)
Enhancing effect of a bay region methyl group on tumorigenicity in newborn mice and mouse skin of enantiomeric bay region diol epoxides formed stereoselectively from methylchrysenes in mouse epidermis. (1987) (33)
Metabolism of N'-nitrosonornicotine by cultured rat esophagus. (1982) (33)
Cell specificity for the pulmonary metabolism of tobacco-specific nitrosamines in the Fischer rat. (1989) (33)
Stereoselective metabolism of nicotine and tobacco-specific N-nitrosamines to 4-hydroxy-4-(3-pyridyl)butanoic acid in rats. (1999) (33)
A Randomized Clinical Trial Examining the Effects of Instructions for Electronic Cigarette Use on Smoking-Related Behaviors, and Biomarkers of Exposure. (2019) (33)
A study of chemical carcinogenesis: Comparative carcinogenicity of 5-methylchrysene, benzo(a)pyrene, and modified chrysenes (1975) (33)
The Association of a Tobacco-Specific Biomarker and Cigarette Consumption and Its Dependence on Host Characteristics (2007) (33)
Biomarkers to assess the utility of potential reduced exposure tobacco products. (2006) (32)
Effect of phenethyl isothiocyanate on the metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by cultured rat lung tissue. (1991) (32)
Detection of Cotinine in Newborn Dried Blood Spots (2007) (32)
Gas chromatographic-mass spectrometric determination of benzo[a]pyrene and chrysene diol epoxide globin adducts in humans. (1997) (32)
Formation of NADP(H) analogs of tobacco-specific nitrosamines in rat liver and pancreatic microsomes. (1994) (32)
Exposure to different sources of second-hand smoke during pregnancy and its effect on urinary cotinine and tobacco-specific nitrosamine (NNAL) concentrations (2012) (32)
Metabolism and pharmacokinetics of N'-nitrosonornicotine in the patas monkey. (2002) (32)
A Study of Reactions of α,β-Unsaturated Carbonyl Compounds with Deoxyguanosine (1988) (32)
A Schiff base is a major DNA adduct of crotonaldehyde. (2001) (32)
A study of tobacco carcinogenesis. XIII. Tumor-promoting subfractions of the weakly acidic fraction. (1975) (32)
Analysis of r-7,t-8,9,c-10-tetrahydroxy-7,8,9,10-tetrahydrobenzo[a]pyrene in human urine: a biomarker for directly assessing carcinogenic polycyclic aromatic hydrocarbon exposure plus metabolic activation. (2011) (31)
Effect of Oral Snus and Medicinal Nicotine in Smokers on Toxicant Exposure and Withdrawal Symptoms: A Feasibility Study (2010) (31)
Effects of ortho-methyl substituents on the mutagenicity of aminobiphenyls and aminonaphthalenes. (1981) (31)
Genetic determinants of cytochrome P450 2A6 activity and biomarkers of tobacco smoke exposure in relation to risk of lung cancer development in the Shanghai cohort study (2016) (31)
Mitochondrial DNA adducts in the lung and liver of F344 rats chronically treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and (S)-4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol. (2009) (31)
Chemical studies on tobacco smoke LXVIII. Analysis of volatile and tobacco-specific nitrosamines in tobacco products. (1980) (31)
Oral Health Effects of Combusted and Smokeless Tobacco Products (2019) (31)
Carcinogen biomarkers for lung or oral cancer chemoprevention trials. (2001) (31)
Formation of formaldehyde adducts in the reactions of DNA and deoxyribonucleosides with alpha-acetates of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), and N-nitrosodimethylamine (NDMA). (2008) (31)
Tobacco carcinogen metabolites and DNA adducts as biomarkers in Head and Neck cancer: Potential screening tools and prognostic indicators (2012) (31)
Effects of alpha-deuterium substitution on the mutagenicity of 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK). (1983) (30)
EFFECTS OF METHYL AND FLUORINE SUBSTITUTION ON THE METABOLIC ACTIVATION AND TUMORIGENICITY OF POLYCYCLIC AROMATIC HYDROCARBONS. (1985) (30)
Tumor-initiating activity of dihydrodiols formed metabolically from 5-methylchrysene. (1980) (30)
Development of liquid chromatography electrospray ionization tandem mass spectrometry methods for analysis of DNA adducts of formaldehyde and their application to rats treated with N-nitrosodimethylamine or 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. (2007) (30)
Comprehensive High-Resolution Mass Spectrometric Analysis of DNA Phosphate Adducts Formed by the Tobacco-Specific Lung Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (2015) (30)
Comparative tumorigenicity of 6-nitrochrysene and its metabolites in newborn mice. (1989) (30)
Methylchrysenes as Probes for the Mechanism of Metabolic Activation of Carcinogenic Methylated Polynuclear Aromatic Hydrocarbons (1986) (30)
Tobacco biomarkers and genetic/epigenetic analysis to investigate ethnic/racial differences in lung cancer risk among smokers (2018) (30)
Metabolism of [D10]Phenanthrene to Tetraols in Smokers for Potential Lung Cancer Susceptibility Assessment: Comparison of Oral and Inhalation Routes of Administration (2011) (30)
The influence of repair pathways on the cytotoxicity and mutagenicity induced by the pyridyloxobutylation pathway of tobacco-specific nitrosamines. (2009) (30)
Temporal stability of urinary and plasma biomarkers of tobacco smoke exposure among cigarette smokers (2010) (30)
Identification of trans-1,2-dihydro-1,2-dihydroxy-6-nitrochrysene as a major mutagenic metabolite of 6-nitrochrysene. (1984) (30)
Metabolism of the carcinogen [3H]6-nitrochrysene in the preweanling mouse: identification of 6-aminochrysene-1,2-dihydrodiol as the probable proximate carcinogenic metabolite. (1988) (30)
Exposure to the carcinogen 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK) in smokers from 3 populations with different risks of lung cancer (2009) (29)
Kinetics of nornicotine and anabasine nitrosation in relation to N'-nitrosonornicotine occurrence in tobacco and to tobacco-induced cancer. (1977) (29)
Urinary concentrations of monohydroxylated polycyclic aromatic hydrocarbons in adults from the U.S. Population Assessment of Tobacco and Health (PATH) Study Wave 1 (2013–2014) (2018) (29)
Liquid chromatography-electrospray ionization tandem mass spectrometry analysis of 7-ethylguanine in human liver DNA. (2007) (29)
Levels of (S)-N'-nitrosonornicotine in U.S. tobacco products. (2013) (29)
Disposition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in bile duct-cannulated rats: stereoselective metabolism and tissue distribution. (2002) (29)
Synthesis of tobacco-specific N-nitrosamines and their metabolites and results of related bioassays. (1996) (29)
Chemical studies on tobacco smoke. XLII. Nitrosonornicotine: presence in tobacco, formation and carcinogenicity. (1976) (29)
Identification of mutagenic dihydrodiols as metabolites of benzo(j)fluoranthene and benzo(k)fluoranthene. (1980) (29)
Effects of butylated hydroxyanisole on the tumorigenicity and metabolism of N-nitrosodimethylamine and N-nitrosopyrrolidine in A/J mice. (1986) (29)
Identification of paraldol-deoxyguanosine adducts in DNA reacted with crotonaldehyde. (2000) (28)
Study of DNA methylation by tobacco-specific N-nitrosamines. (1985) (28)
Quantitation of 7-ethylguanine in leukocyte DNA from smokers and nonsmokers by liquid chromatography-nanoelectrospray-high resolution tandem mass spectrometry. (2011) (28)
Uptake of the Tobacco-Specific Lung Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-Butanone by Moldovan Children (2006) (28)
Tumor initiating activity of 5,11-dimethylchrysene and the structural requirements favoring carcinogenicity of methylated polynuclear aromatic hydrocarbons. (1979) (28)
Analysis of tobacco-specific nitrosamines in Moldovan cigarette tobacco. (2002) (28)
The sphingolipid degradation product trans-2-hexadecenal forms adducts with DNA. (2012) (28)
Stereoselective metabolism and tissue retention in rats of the individual enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), metabolites of the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). (2004) (27)
Mutagenicity, metabolism and DNA adduct formation of 6-nitrochrysene in Salmonella typhimurium. (1989) (27)
Updated procedure for the safety evaluation of natural flavor complexes used as ingredients in food. (2018) (27)
The bay-region geometry of some 5-methylchrysenes: steric effects in 5,6- and 5,12-dimethylchrysenes. (1984) (27)
The ratio of a urinary tobacco-specific lung carcinogen metabolite to cotinine is significantly higher in passive than in active smokers (2011) (27)
Identification of the major adducts formed by reaction of 5-methylchrysene anti-dihydrodiol-epoxides with DNA in vitro. (1984) (27)
Tobacco-specific nitrosamine-hemoglobin adducts. (1994) (27)
Exposure to nicotine and a tobacco-specific carcinogen increase with duration of use of smokeless tobacco (2008) (27)
Analysis of Acrolein-Derived 1, N2-Propanodeoxyguanosine Adducts in Human Lung DNA from Smokers and Nonsmokers. (2019) (27)
Contrasting incidence of ras mutations in rat mammary and mouse skin tumors induced by anti-benzo[c]phenanthrene-3,4-diol-1,2-epoxide. (1994) (27)
Combined Analysis of r-1,t-2,3,c-4-Tetrahydroxy-1,2,3,4-Tetrahydrophenanthrene and 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in Smokers' Plasma (2006) (26)
Comparative metabolic activation in mouse skin of the weak carcinogen 6-methylchrysene and the strong carcinogen 5-methylchrysene. (1985) (26)
2-Phenethyl Isothiocyanate, Glutathione S-transferase M1 and T1 Polymorphisms, and Detoxification of Volatile Organic Carcinogens and Toxicants in Tobacco Smoke (2016) (26)
Association of CYP2A6 activity with lung cancer incidence in smokers: The multiethnic cohort study (2017) (26)
Metabolic beta-hydroxylation and N-oxidation of N'-nitrosonornicotine. (1980) (26)
Synthesis and properties of an acetaldehyde-derived oligonucleotide interstrand cross-link. (2005) (26)
Dihydromethysticin from kava blocks tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis and differentially reduces DNA damage in A/J mice. (2014) (26)
Effects of 6-Week Use of Very Low Nicotine Content Cigarettes in Smokers With Serious Mental Illness (2019) (26)
Smoking behaviour and toxin exposure during six weeks use of a potential reduced exposure product: Omni (2004) (25)
High Level of Tobacco Carcinogen–Derived DNA Damage in Oral Cells Is an Independent Predictor of Oral/Head and Neck Cancer Risk in Smokers (2017) (25)
Berry ellagitannins may not be sufficient for prevention of tumors in the rodent esophagus. (2010) (25)
Harnessing the Power of Cruciferous Vegetables: Developing a Biomarker for Brassica Vegetable Consumption Using Urinary 3,3′-Diindolylmethane (2016) (25)
Tobacco-specific nitrosamines. (1994) (25)
Lack of tumorigenicity of cholesterol epoxides and estrone-3,4-quinone in the rat mammary gland. (1996) (25)
Combined analysis of N'-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in the urine of cigarette smokers and e-cigarette users. (2015) (25)
Kava Blocks 4-(Methylnitrosamino)-1-(3-pyridyl)-1-Butanone–Induced Lung Tumorigenesis in Association with Reducing O6-methylguanine DNA Adduct in A/J Mice (2014) (25)
Comparative carcinogenicity of o-toluidine hydrochloride and o-nitrosotoluene in F-344 rats. (1982) (25)
Chemopreventive agents modulate the protein expression profile of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumors in A/J mice. (2007) (25)
Influence of bay-region methyl group on formation of 5-methylchrysene dihydrodiol epoxide:DNA adducts in mouse skin. (1982) (25)
Detection of exocyclic guanine adducts in hydrolysates of hepatic DNA of rats treated with N-nitrosopyrrolidine and in calf thymus DNA reacted with alpha-acetoxy-N-nitrosopyrrolidine. (1989) (25)
Clues to the Etiology of Childhood Brain Cancer: N-Nitroso Compounds, Polyomaviruses, and Other Factors of Interest (2001) (25)
Model studies in tobacco carcinogenesis with the Syrian golden hamster. (1979) (25)
Endogenous formation of N'-nitrosonornicotine in F344 rats in the presence of some antioxidants and grape seed extract. (2007) (24)
Synthesis and mutagenicity of modified chrysenes related to the carcinogen, 5-methylchrysene. (2002) (24)
Oxidation of polynuclear aromatic hydrocarbons with ceric ammonium sulfate: preparation of quinones and lactones (1988) (24)
Improved Photochemical Synthesis of 5-Methylchrysene Derivatives and Its Application to the Preparation of 7,8-dihydro-7,s-dihydroxy-s-methylchrysene (2002) (24)
Smokeless tobacco brand switching: a means to reduce toxicant exposure? (2007) (24)
Stereospecific deuterium substitution attenuates the tumorigenicity and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). (2003) (24)
Anthocyanins, anthocyanin derivatives, and colorectal cancer (2013) (24)
Lung tumorigenesis suppressing effects of a commercial kava extract and its selected compounds in A/J mice. (2011) (24)
On the analysis of 1-nitronaphthalene, 1-nitropyrene and 6-nitrochrysene in cigarette smoke. (1985) (24)
Environmental tobacco smoke and lung cancer: the emerging role of carcinogen biomarkers and molecular epidemiology. (1994) (24)
Inhibitory effects of 6-phenylhexyl isothiocyanate on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolic activation and lung tumorigenesis in rats. (1996) (24)
Metabolic Activation and DNA Interactions of Carcinogenic N-Nitrosamines to Which Humans Are Commonly Exposed (2022) (24)
The Metabolism of Cyclic Nitrosamines (1981) (24)
Induction of mammary cancer by 6-nitrochrysene in female CD rats. (1993) (24)
α-Hydroxylation of N-nitrosopyrrolidine and N′-nitrosonornicotine by human liver microsomes (1979) (23)
Reactions of alpha-acetoxy-N-nitrosopyrrolidine and alpha-acetoxy-N-nitrosopiperidine with deoxyguanosine: formation of N2-tetrahydrofuranyl and N2-tetrahydropyranyl adducts. (1995) (23)
Tobacco-Specific Nitrosamines (NNAL, NNN, NAT, and NAB) Exposures in the US Population Assessment of Tobacco and Health (PATH) Study Wave 1 (2013-2014). (2020) (23)
Chapter 11 – Nitrosamines derived from nicotine and other tobacco alkaloids (1999) (23)
Analysis for N2-(pyridyloxobutyl)deoxyguanosine adducts in DNA of tissues exposed to tritium-labeled 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N'-nitrosonornicotine. (1989) (23)
Detection of DNA and globin adducts of polynuclear aromatic hydrocarbon diol epoxides by gas chromatography-mass spectrometry and -3H-CH3I postlabeling of released tetraols. (1996) (23)
Oral Cell DNA Adducts as Potential Biomarkers for Lung Cancer Susceptibility in Cigarette Smokers. (2017) (23)
Kinetics of DNA methylation by the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in F344 rats. (1984) (23)
Smokeless tobacco and cigarette smoking: chemical mechanisms and cancer prevention (2022) (23)
Tobacco‐specific N‐nitrosamines and polycyclic aromatic hydrocarbons in cigarettes smoked by the participants of the Shanghai Cohort Study (2016) (23)
Genetic variability in the metabolism of the tobacco‐specific nitrosamine 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK) to 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanol (NNAL) (2012) (22)
Evidence that a hemoglobin adduct of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone is a 4-(3-pyridyl)-4-oxobutyl carboxylic acid ester. (1992) (22)
Metabolites of the Polycyclic Aromatic Hydrocarbon Phenanthrene in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer (2016) (22)
Effects of the co-carcinogen catechol on benzo[a]pyrene metabolism and DNA adduct formation in mouse skin. (1986) (22)
A biomarker of exposure to environmental tobacco smoke (ETS) and Ernst Wynder's opinion about ETS and lung cancer. (2006) (22)
Identification of more than 100 structurally unique DNA-phosphate adducts formed during rat lung carcinogenesis by the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (2018) (22)
Acrolein Exposure in Hookah Smokers and Non-Smokers Exposed to Hookah Tobacco Secondhand Smoke: Implications for Regulating Hookah Tobacco Products (2018) (22)
Smokeless tobacco topography and toxin exposure. (2005) (22)
High Pressure Liquid Chromatographic Assay for α Hydroxylation of N-Nitrosopyrrolidine by Isolated Rat Liver Microsomes (1978) (22)
Comparative tumorigenicity of N-nitroso-2-hydroxymorpholine, N-nitrosodiethanolamine and N-nitrosomorpholine in A/J mice and F344 rats. (1989) (22)
A cyclic N7,C-8 guanine adduct of N-nitrosopyrrolidine (NPYR): formation in nucleic acids and excretion in the urine of NPYR-treated rats. (1997) (22)
Tumor-initiating activity on mouse skin of bay region diol-epoxides of 5,6-dimethylchrysene and benzo[c]phenanthrene. (1993) (22)
High-performance liquid chromatographic analysis of metabolites of the nicotine-derived nitrosamines, N'-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. (1985) (22)
Synthesis and mutagenicity of 5,11-dimethylchrysene and some methyl-oxidized derivatives of 5-methylchrysene. (1979) (22)
Detection of 7-(2'-carboxyethyl)guanine but not 7-carboxymethylguanine in human liver DNA. (2010) (22)
Formation and tumorigenicity of benzo[b]fluoranthene metabolites in mouse epidermis. (1987) (22)
FEMA GRAS assessment of natural flavor complexes: Citrus-derived flavoring ingredients. (2019) (21)
Di-tert-butyloxadiaziridine, the cyclic form of an azoxy group. Ring-chain isomerism in three-membered rings (1967) (21)
Chemical studies on tobacco smoke LVI. Tobacco specific nitrosamines: origins, carcinogenicity and metabolism. (1978) (21)
Evaluation of cysteine adduct formation in rat hemoglobin by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and related compounds. (1990) (21)
Reaction of alpha-acetoxy-N-nitrosopiperidine with deoxyguanosine: oxygen-dependent formation of 4-oxo-2-pentenal and a 1,N2-ethenodeoxyguanosine adduct. (1992) (21)
A Urinary Metabolite of Phenanthrene as a Biomarker of Polycyclic Aromatic Hydrocarbon Metabolic Activation in Workers Exposed to Residual Oil Fly Ash (2005) (21)
Effects of fluorine substitution on the tumor initiating activity and metabolism of 5-hydroxymethylchrysene, a tumorigenic metabolite of 5-methylchrysene. (1981) (21)
Relationship of the oxidative damage biomarker 8-epi-prostaglandin F2&agr; to risk of lung cancer development in the Shanghai Cohort Study (2018) (20)
Benzene Uptake and Glutathione S-transferase T1 Status as Determinants of S-Phenylmercapturic Acid in Cigarette Smokers in the Multiethnic Cohort (2016) (20)
Mutagenicity of K-region derivatives of 1-nitropyrene; remarkable activity of 1- and 3-nitro-5H-phenanthro[4,5-bcd]pyran-5-one. (1986) (20)
Skin bioassays in tobacco carcinogenesis. (1983) (20)
Tumorigenicity of the tobacco-specific carcinogen 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone in infant mice. (1991) (20)
ENOL ESTERS. XV. SYNTHESIS OF HIGHLY HINDERED ESTERS VIA ISOPROPENYL ESTER INTERMEDIATES (1972) (20)
Tobacco specific N-nitrosamines: occurrence and bioassays. (1982) (20)
Effects of alpha-deuterium substitution on the tumorigenicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in F344 rats. (1987) (20)
N-nitroso-N-methyldodecylamine and N-nitroso-N-methyltetradecylamine in hair-care products. (1982) (20)
Metabolic activation of benzo[c]phenanthrene by cytochrome P450 enzymes in human liver and lung. (2001) (19)
Reactions of α-acetoxy-N-nitrosopyrrolidine with deoxyguanosine and DNA (2001) (19)
DNA Adduct Formation from Metabolic 5'-Hydroxylation of the Tobacco-Specific Carcinogen N'-Nitrosonornicotine in Human Enzyme Systems and in Rats. (2016) (19)
Evaluation of Nitrosamide Formation in the Cytochrome P450-Mediated Metabolism of Tobacco-Specific Nitrosamines. (2016) (19)
Identification of mutagenic metabolites formed by C-hydroxylation and nitroreduction of 5-nitroacenaphthene in rat liver. (1982) (19)
Analysis and Identification of 2'-Deoxyadenosine-Derived Adducts in Lung and Liver DNA of F-344 Rats Treated with the Tobacco-Specific Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and Enantiomers of its Metabolite 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol. (2018) (19)
A/J mouse lung tumorigenesis by the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its inhibition by arylalkyl isothiocyanates. (1991) (19)
Synthesis and Fluorescence Spectra of Structural Analogues of Potential Benzo[b]fluoranthene-DNA Adducts (1985) (19)
A sensitive method for detecting in vivo formation of N-nitrosomorpholine and its application to rats given low doses of morpholine and sodium nitrite. (1984) (19)
Longitudinal stability in cigarette smokers of urinary biomarkers of exposure to the toxicants acrylonitrile and acrolein (2019) (19)
FEMA GRAS assessment of natural flavor complexes: Mint, buchu, dill and caraway derived flavoring ingredients. (2019) (19)
Dimethylchrysene diol epoxides: mutagenicity in Salmonella typhimurium, tumorigenicity in newborn mice, and reactivity with deoxyadenosine in DNA. (1992) (19)
Analysis of phenanthrene diol epoxide mercapturic acid detoxification products in human urine: relevance to molecular epidemiology studies of glutathione S-transferase polymorphisms. (2008) (18)
Formation of the cyclic 1,N2-glyoxal-deoxyguanosine adduct upon reaction of N-nitroso-2-hydroxymorpholine with deoxyguanosine. (1985) (18)
Phenanthrene Metabolism in Smokers: Use of a Two-Step Diagnostic Plot Approach to Identify Subjects with Extensive Metabolic Activation (2012) (18)
Elevated Levels of Mercapturic Acids of Acrolein and Crotonaldehyde in the Urine of Chinese Women in Singapore Who Regularly Cook at Home (2015) (18)
Comparative DNA binding of polynuclear aromatic hydrocarbons and their dihydrodiol and bay region diolepoxide metabolites in newborn mouse lung and liver. (1991) (18)
Increased pouch sizes and resulting changes in the amounts of nicotine and tobacco-specific N-nitrosamines in single pouches of Camel Snus and Marlboro Snus. (2012) (18)
Reactivity with DNA bases and mutagenicity toward Salmonella typhimurium of methylchrysene diol epoxide enantiomers. (1988) (18)
Identification of 4-(methylnitrosamino)-1-[3-(6-hydroxypyridyl)]-1-butanone as a urinary metabolite of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in rodents. (1993) (18)
The effect of chronic ethanol consumption on the tumorigenicity of N-nitrosopyrrolidine in male Syrian golden hamsters. (1986) (18)
Identification of metabolites of benzo[b]fluoranthene. (1982) (18)
Synthesis of Angular Ring Methoxy-5-methylchrysenes and 5-Methylchrysenols (1981) (18)
Preferential Glutathione Conjugation of a Reverse Diol Epoxide Compared with a Bay Region Diol Epoxide of Benzo[a]pyrene in Human Hepatocytes (2010) (18)
Metabolism and DNA binding of 1-nitropyrene and 1-nitrosopyrene in newborn mice. (1988) (18)
High stereoselectivity in mouse skin metabolic activation of methylchrysenes to tumorigenic dihydrodiols. (1987) (18)
Inhibition of tobacco-specific nitrosamine 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK) tumorigenesis with aromatic isothiocyanates. (1991) (18)
The safety evaluation of food flavouring substances: the role of metabolic studies. (2018) (18)
Identification of adducts formed in the reactions of 5'-acetoxy-N'-nitrosonornicotine with deoxyadenosine, thymidine, and DNA. (2008) (17)
Reactions with Deoxyguanosine of 4-(Carbethoxynitrosamino)-1-(3-pyridyl)-1-butanone, a Model Compound for α-Hydroxylation of Tobacco-Specific Nitrosamines (1986) (17)
Hemoglobin adducts as biomarkers of exposure to and metabolic activation of carcinogenic tobacco-specific nitrosamines. (1991) (17)
Proximity effects. XLVIII. Aprotic decomposition of 2-phenylcyclooctanone p-toluenesulfonylhydrazone and 3-phenylcyclooctanone p-toluenesulfonylhydrazone (1967) (17)
Combinations of N-Acetyl-S-(N-2-Phenethylthiocarbamoyl)-L-Cysteine and myo-Inositol Inhibit Tobacco Carcinogen–Induced Lung Adenocarcinoma in Mice (2008) (17)
Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone pulmonary metabolism and tumorigenicity in mice by analogues of the investigational chemotherapeutic drug 4-ipomeanol. (1992) (17)
Development of methods to monitor exposure to 1-nitropyrene. (1994) (17)
Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone mouse lung tumorigenesis by arylalkynes, mechanism-based inactivators of cytochrome P450. (1993) (17)
Dose-dependent detoxication of the airborne pollutant benzene in a randomized trial of broccoli sprout beverage in Qidong, China. (2019) (17)
GRASr2 evaluation of aliphatic acyclic and alicyclic terpenoid tertiary alcohols and structurally related substances used as flavoring ingredients. (2014) (17)
N-nitrosamines: environmental occurrence, in vivo formation and metabolism. (1982) (17)
Dose-response study of myo-inositol as an inhibitor of lung tumorigenesis induced in A/J mice by benzo. (2001) (16)
Carcinogenicity and metabolic activation of tobacco-specific nitrosamines: current status and future prospects. (1984) (16)
The safety evaluation of food flavoring substances: the role of genotoxicity studies (2020) (16)
Identification of adducts formed in the reaction of 5'-acetoxy-N'-nitrosonornicotine with deoxyguanosine and DNA. (2006) (16)
Effects of route of administration and dose on the carcinogenicity of N-nitrosodiethanolamine in the Syrian golden hamster. (1983) (16)
Mammary carcinogenicity in female CD rats of a diol epoxide metabolite of fluoranthene, a commonly occurring environmental pollutant. (1995) (16)
Regiospecificity in the metabolism of the homologous cyclic nitrosamines, N'-nitrosonornicotine and N'-nitrosoanabasine. (1982) (16)
Methyl DNA Phosphate Adduct Formation in Rats Treated Chronically with 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and Enantiomers of Its Metabolite 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (2017) (16)
Preferential glutathione conjugation of a reverse diol epoxide compared to a bay region diol epoxide of phenanthrene in human hepatocytes: relevance to molecular epidemiology studies of glutathione-s-transferase polymorphisms and cancer. (2009) (15)
Safety evaluation of substituted thiophenes used as flavoring ingredients. (2017) (15)
FEMA GRAS assessment of natural flavor complexes: Clove, Cinnamon leaf and West Indian bay leaf-derived flavoring ingredients. (2020) (15)
Combined Analysis of the Tobacco Metabolites Cotinine and 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol in Human Urine (2014) (15)
Reactions of 2,6-dimethyl-1,3-dioxane-4-ol (aldoxane) with deoxyguanosine and DNA. (2001) (15)
Contrasting Disposition and Metabolism of Topically Applied Benzo(a)pyrene, trans-7,8-Dihydroxy-7,8-dihydrobenzo(a)pyrene, and 7β,8α-Dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene in Mouse Epidermis in Vivo (1987) (15)
Comparative tumorigenicity of nitrochrysene isomers in newborn mice. (1992) (15)
Analysis of O(6)-[4-(3-Pyridyl)-4-oxobut-1-yl]-2'-deoxyguanosine and Other DNA Adducts in Rats Treated with Enantiomeric or Racemic N'-Nitrosonornicotine. (2016) (15)
Interaction of CYP1B1, cigarette-smoke carcinogen metabolism, and lung cancer risk. (2010) (15)
Metabolic activation of 6-nitrochrysene in explants of human bronchus and in isolated rat hepatocytes. (1989) (15)
A STUDY OF CHEMICAL CARCINOGENESIS. 14. HYDROLYSIS OF MODEL COMPOUNDS FOR α-HYDROXYLATION OF THE CARCINOGENS N-NITROSOPYRROLIDINE AND N′-NITROSONORNICOTINE (1979) (15)
Liquid chromatography--electrospray ionization mass spectrometric detection of an ethenodeoxyguanosine adduct and its hemiaminal precursors in DNA reacted with alpha-acetoxy-N-nitrosopiperidine and cis-4-Oxo-2-pentenal. (1996) (15)
Comparative mutagenicity of 4-(carbethoxynitrosamino)-4-(3-pyridyl)butanal and 4-(carbethoxynitrosamino)-1-(3-pyridyl)-1-butanone, model compounds for alpha-hydroxylation of N'-nitrosonornicotine. (1986) (15)
4 – Tobacco Carcinogenesis (1978) (15)
Mass Spectra of Tobacco Alkaloid - Derived Nitrosamines, their Metabolites, and Related Compounds (1981) (15)
Unexpected mutagen in fish (1995) (14)
DNA and hemoglobin adducts as markers of metabolic activation of tobacco-specific carcinogens. (1992) (14)
N-Nitroso-2-hydroxymorpholine, a mutagenic metabolite of N-nitrosodiethanolamine. (1984) (14)
Rates of hydrolysis and extents of DNA binding of 5-methylchrysene dihydrodiol epoxides. (1985) (14)
Pilot in Vivo Structure-Activity Relationship of Dihydromethysticin in Blocking 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced O6-Methylguanine and Lung Tumor in A/J Mice. (2017) (14)
Preparation of pyridine-N-glucuronides of tobacco-specific nitrosamines. (2001) (14)
Lactols in Hydrolysates of DNA Treated with α-Acetoxy-N-nitrosopyrrolidine or Crotonaldehyde (1998) (14)
Major tobacco companies have technology to reduce carcinogen levels but do not apply it to popular smokeless tobacco products (2010) (14)
Investigation of the reaction of myosmine with sodium nitrite in vitro and in rats. (2007) (14)
Identification of adducts formed in the reaction of alpha-acetoxy-N-nitrosopyrrolidine with deoxyribonucleosides and DNA. (2007) (14)
Benzene oxide is a substrate for glutathione S-transferases. (2015) (14)
Self‐reported Tobacco use does not correlate with carcinogen exposure in smokers with head and neck cancer (2015) (14)
Influence of mixed-function oxidase inducers on the in vitro metabolism of N'-nitrosonornicotine by rat and hamster liver microsomes. (1981) (14)
Differences in exposure to toxic and/or carcinogenic volatile organic compounds between Black and White cigarette smokers (2019) (14)
Effects of cessation of cigarette smoking on eicosanoid biomarkers of inflammation and oxidative damage (2019) (14)
Synthesis of potential phenolic metabolites of benzo[b]fluoranthene (1986) (14)
Formation of acyclic and cyclic guanine adducts in DNA reacted with alpha-acetoxy-N-nitrosopyrrolidine. (1989) (13)
Carcinogenic components of tobacco and tobacco smoke: A 2022 update. (2022) (13)
Synthesis of 5'-carboxy-N'-nitrosonornicotine and 5'-[14C]carboxy-N'-nitrosonornicotine (1987) (13)
Hope or hazard? What research tells us about "potentially reduced-exposure" tobacco products (2005) (13)
Increased Acrolein-DNA Adducts in Buccal Brushings of e-Cigarette Users. (2022) (13)
Effect of cigarette smoking on urinary 2-hydroxypropylmercapturic acid, a metabolite of propylene oxide. (2014) (13)
Pyridylhydroxybutyl and pyridyloxobutyl DNA phosphate adduct formation in rats treated chronically with enantiomers of the tobacco-specific nitrosamine metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (2017) (13)
Cigarette Smokers vs. Co-users of Cannabis and Cigarettes: Exposure to Toxicants. (2020) (13)
Development of a monoclonal antibody-based immunoassay for cyclic DNA adducts resulting from exposure to crotonaldehyde. (1987) (13)
Preferential metabolic activation of N-nitrosopiperidine as compared to its structural homologue N-nitrosopyrrolidine by rat nasal mucosal microsomes. (2003) (13)
Biomarkers of Exposure among Adult Smokeless Tobacco Users in the Population Assessment of Tobacco and Health Study (Wave 1, 2013–2014) (2020) (13)
Quantitation of N-acetyl-S-(9,10-dihydro-9-hydroxy-10-phenanthryl)-L-cysteine in human urine: comparison with glutathione-S-transferase genotypes in smokers. (2006) (13)
Formation of N2-tetrahydrofuranyl and N2-tetrahydropyranyl adducts in the reactions of alpha-acetoxy-N-nitrosopyrrolidine and alpha-acetoxy-N-nitrosopiperidine with DNA. (1995) (13)
Exposure to Nicotine and Toxicants Among Dual Users of Tobacco Cigarettes and E-Cigarettes: Population Assessment of Tobacco and Health (PATH) Study, 2013-2014. (2021) (12)
On the metabolic activation of 5-methylchrysene (1978) (12)
FEMA GRAS assessment of natural flavor complexes: Lavender, Guaiac Coriander-derived and related flavoring ingredients. (2020) (12)
Longitudinal study of [D10]phenanthrene metabolism by the diol epoxide pathway in smokers (2013) (12)
Synthesis of stereospecifically deuterated 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) iastereomers and metabolism by A/J mouse lung microsomes and cytochrome p450 2A5. (2003) (12)
A study of snuff carcinogenesis. (1987) (12)
More than 500 trillion molecules of strong carcinogens per cigarette: use in product labelling? (2011) (12)
Metabolically activated carcinogens and mutations in the p53 tumor suppressor gene in lung cancer. (2000) (12)
N-nitrosodiethanolamine: analysis, formation in tobacco products and carcinogenicity in Syrian golden hamsters. (1982) (12)
Quantitation of enantiomers of r-7,t-8,9,c-10-tetrahydroxy-7,8,9,10-tetrahydrobenzo[a]-pyrene in human urine: evidence supporting metabolic activation of benzo[a]pyrene via the bay region diol epoxide. (2014) (12)
Smokeless tobacco reduction: preliminary study of tobacco-free snuff versus no snuff. (2008) (12)
Analysis of adducts in hepatic DNA of rats treated with N-nitrosopyrrolidine. (2007) (12)
Carcinogenicity of tobacco-specific N-nitrosamines (TSNA): the role of the vascular network in the selection of target organs. (1991) (12)
METABOLIC β-HYDROXYLATION AND N-OXIDATION OF N′-NITROSONORNICOTINE (1981) (12)
FEMA GRAS assessment of natural flavor complexes: Cinnamomum and Myroxylon-derived flavoring ingredients. (2019) (12)
A study of chemical carcinogenesis. 14. Hydrolysis of model compounds for .alpha.-hydroxylation of the carcinogens N-nitrosopyrrolidine and N'-nitrosonornicotine (1979) (12)
Abstinence and Relapse Rates Following a College Campus-Based Quit & Win Contest (2010) (11)
Formation and Distribution of NNK Metabolites in an Isolated Perfused Rat Lung (2010) (11)
Urinary biomarkers to assess exposure of cats to environmental tobacco smoke. (2007) (11)
Mutagenicity and tumor initiating activity of methylated benzo[k] fluoranthenes. (1985) (11)
Quality assurance and harmonization for targeted biomonitoring measurements of environmental organic chemicals across the Children's Health Exposure Analysis Resource laboratory network. (2021) (11)
Metabolism and DNA Adduct Formation of Tobacco-Specific N-Nitrosamines (2022) (11)
Associations Between Genetic Ancestries and Nicotine Metabolism Biomarkers in the Multiethnic Cohort Study. (2015) (11)
Elevated levels of 1‐hydroxypyrene and N′‐nitrosonornicotine in smokers with head and neck cancer: A matched control study (2013) (11)
Quantitative Liquid Chromatography-Nanoelectrospray Ionization-High Resolution Tandem Mass Spectrometry Analysis of Acrolein-DNA Adducts and Etheno-DNA Adducts in Oral Cells from Cigarette Smokers and Non-smokers. (2020) (11)
Identification of New Markers of Alcohol-Derived DNA Damage in Humans (2021) (11)
Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification (2016) (11)
Analytical assessment of e-cigarettes: From contents to chemical and particle exposure profiles, 1st edition (2016) (11)
Synthesis of 6-methylchrysene-1,2-diol-3,4-epoxides and comparison of their mutagenicity to 5-methylchrysene-1,2-diol-3,4-epoxides. (1986) (11)
Reactions of alpha-acetoxy-N-nitrosopyrrolidine and crotonaldehyde with DNA. (1999) (11)
Comparative tumor initiating activity of 10-methylbenzo-[a]pyrene, 7,10-dimethylbenzo[a]pyrene and benzo[a]pyrene. (1978) (11)
Dual-label high-performance liquid chromatographic assay for femtomole levels of benzo[a]pyrene metabolites. (1985) (11)
Investigations on the molecular dosimetry of tobacco-specific N-nitrosamines. (1987) (11)
Structure of 5-Methylchrysene, C19H14 (1984) (11)
Prediagnostic levels of urinary 8-epi-prostaglandin F2α and prostaglandin E2 metabolite, biomarkers of oxidative damage and inflammation, and risk of hepatocellular carcinoma. (2019) (11)
Distribution and metabolism of N'-nitrosonornicotine in the miniature pig. (1987) (11)
Analysis of N'-nitrosonornicotine enantiomers in human urine by chiral stationary phase liquid chromatography-nanoelectrospray ionization-high resolution tandem mass spectrometry. (2017) (11)
Formation, Occurrence, and Carcinogenicity ofN-Nitrosamines in Tobacco Products (1981) (11)
Deoxygenated phosphorothioate inositol phosphate analogs: synthesis, phosphatase stability, and binding affinity. (2008) (10)
Clinical and Biochemical Studies Support Smokeless Tobacco's Carcinogenic Potential in the Human Oral Cavity (2013) (10)
Tumor-initiating activity and in vitro metabolism of 6-nitrochrysene and 1-nitropyrene (1982) (10)
Urinary cyanoethyl mercapturic acid, a biomarker of the smoke toxicant acrylonitrile, clearly distinguishes smokers from non-smokers. (2020) (10)
Mutational spectra for 5,6-dimethylchrysene 1,2-dihydrodiol 3,4-epoxides in the supF gene of pSP189. (1995) (10)
Assay for Microsomal α-Hydroxylation of N ′-Nitrosonornicotine and Determination of the Deuterium Isotope Effect for α-Hydroxylation (1979) (10)
Effects of catechol on the induction of tumors in mouse skin by 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrenes. (1989) (10)
Determination of Hemoglobin and Serum Albumin Adducts of Benzo[a]Pyrene by Gas Chromatography-Mass Spectrometry in Humans and Their Relation to Exposure and to other Biological Markers (1999) (10)
Synthesis and Mutagenicity of Dihydrodiol Metabolites of Benzo[b] fluoranthene (2002) (10)
Metabolism of benzo[a]pyrene and 7β,8α-dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene in lung and liver of newborn mice (1989) (10)
Relationships between the Nicotine Metabolite Ratio and a Panel of Exposure and Effect Biomarkers: Findings from Two Studies of U.S. Commercial Cigarette Smokers (2020) (10)
Comparative analysis of tobacco-specific nitrosamines and total N-nitroso compounds in moldovan cigarette tobacco. (2005) (10)
Cyclic azoxy compounds-relation of structural considerations to nmr spectra (1969) (10)
Synthesis and mutagenicity of 5-alkyl-substituted chrysene-1,2-diol-3,4-epoxides. (1988) (10)
Null association between frequency of cured meat consumption and methylvaline and ethylvaline hemoglobin adduct levels: the N-nitroso brain cancer hypothesis. (2002) (10)
A study of chemical carcinogenesis 4. Synthesis of the carbon-14 labelled carcinogens 5-methylchrysene, 2-methyl-aniline and 3-methyl-2-naphthylamine (1978) (10)
Bioassay for carcinogenicity of 3,2'-dimethyl-4-nitrosobiphenyl, O-nitrosotoluene, nitrosobenzene and the corresponding amines in Syrian golden hamsters. (1983) (10)
Consumption of watercress fails to alter coumarin metabolism in humans. (2001) (10)
Contrasting disposition and metabolism of topically applied benzo(a)pyrene, trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and 7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene in mouse epidermis in vivo. (1987) (9)
Chemical Carcinogens in Tobacco (1987) (9)
FEMA expert panel review of p-mentha-1,8-dien-7-al genotoxicity testing results. (2016) (9)
Corrigendum: Absolute configuration of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol formed metabolically from 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (Carcinogenesis (1997) 18 (1851-1854)) (2000) (9)
Comparative tumorigenicity in newborn mice of chrysene- and 5-alkylchrysene-1,2-diol-3,4-epoxides. (1991) (9)
FEMA GRAS assessment of natural flavor complexes: Eucalyptus oil and other cyclic ether-containing flavoring ingredients. (2021) (9)
Comparative tumorigenicity of dimethylchrysenes in mouse skin. (1992) (9)
THE POSSIBLE ROLE OF NITROARENES IN HUMAN CANCER (1990) (9)
The Impact of One-week Dietary Supplementation with Kava on Biomarkers of Tobacco Use and Nitrosamine-based Carcinogenesis Risk among Active Smokers (2020) (9)
Mass Spectrometric Quantitation of Pyridyloxobutyl DNA Phosphate Adducts in Rats Chronically Treated with N'-Nitrosonornicotine. (2019) (9)
Synthesis of [3,3-D2]4-hydroxy-1-(3-pyridyl)-1-butanone, an internal standard for analysis of tobacco-specific nitrosamine hemoglobin and DNA adducts (1993) (9)
The effects of bay-region methyl substitution on 6-nitrochrysene mutagenicity in Salmonella typhimurium and tumorigenicity in newborn mice. (1989) (9)
Preliminary study on reducing oral moist snuff use. (2003) (9)
GRAS 28 flavoring substances (2018) (9)
Synthesis of N-nitrosamino aldehydes (1976) (9)
Synthesis of methylated benzo[b]fluoranthenes and benzo[k]fluoranthenes (2002) (9)
Chromatographic conditions for separation phosphates of 32P-labeled phosphates of major polynuclear aromatic hydrocarbon—deoxyribonucleoside adducts (1989) (9)
N-Nitroso-N-methyldodecylamine and N-nitroso-N-methyltetradecylamine in household dishwashing liquids. (1982) (8)
Evidence for endogenous formation of the hepatocarcinogen N-nitrosodihydrouracil in rats treated with dihydrouracil and sodium nitrite: a potential source of human hepatic DNA carboxyethylation. (2013) (8)
Exposure to a Tobacco-Specific Lung Carcinogen in Adolescent versus Adult Smokers (2008) (8)
Mutagenicity and tumor initiating activity of methylated benzo[b]fluoranthenes. (1985) (8)
New aspects of DNA adduct formation by the carcinogens crotonaldehyde and acetaldehyde. (2001) (8)
In vivo binding of 1-nitropyrene to albumin in the rat. (1994) (8)
Longitudinal stability in cigarette smokers of urinary eicosanoid biomarkers of oxidative damage and inflammation (2019) (8)
Effects of chronic ethanol consumption on benzo(a)pyrene metabolism and glutathione S-transferase activities in Syrian golden hamster cheek pouch and liver. (1986) (8)
Identification of 4-(3-Pyridyl)-4-oxobutyl-2′-deoxycytidine Adducts Formed in the Reaction of DNA with 4-(Acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone: A Chemically Activated Form of Tobacco-Specific Carcinogens (2017) (8)
FEMA GRAS assessment of natural flavor complexes: Origanum oil, thyme oil and related phenol derivative-containing flavoring ingredients. (2021) (8)
Synthesis of K-region derivatives of the carcinogen 1-nitropyrene. (1986) (8)
Cancer Prevention with Berries: Role of Anthocyanins (2010) (8)
Deguelin as a chemopreventive agent in mouse lung tumorigenesis induced by tobacco smoke carcinogens. (2005) (7)
Metastasis to the F344 Rat Pancreas from Lung Cancer Induced by 4-(Methylnitrosamino)- 1-(3-pyridyl)-1-butanone and Enantiomers of Its Metabolite 4-(Methylnitrosamino)-1-(3-pyridyl)- 1-butanol, Constituents of Tobacco Products (2018) (7)
Formation of cyclic nucleic acid adducts from some simple alpha, beta-unsaturated carbonyl compounds and cyclic nitrosamines. (1986) (7)
Metabolism and DNA binding of 5,6-dimethylchrysene in mouse skin. (1992) (7)
Oral creatine supplementation in humans does not elevate urinary excretion of the carcinogen N-nitrososarcosine. (2006) (7)
N-Nitroso(2-hydroxyethyl)glycine, a urinary metabolite of N,N-dinitrosopiperazine with potential utility as a monitor for its formation in vivo from piperazine. (1984) (7)
Conference on advances in the biology and chemistry of N-nitroso and related compounds. (1989) (7)
Comparative tumor initiating activities of cyclopentano and methyl derivatives of 5-methylchrysene and chrysene. (1990) (7)
Synthesis of 4‐ (methylnitrosamino)‐1‐ (3‐pyridyl)‐1‐butanone, 4‐ (carbethoxynitrosamino)‐1‐ (3‐pyridyl)‐1‐butanone, and N′ ‐nitrosonornicotine labelled with tritium in the pyridine ring (1988) (7)
Effects of 2-Phenethyl Isothiocyanate on Metabolism of 1,3-Butadiene in Smokers (2019) (7)
Mass spectrometric analysis of a cyclic 7,8-butanoguanine adduct of N-nitrosopyrrolidine: comparison to other N-nitrosopyrrolidine adducts in rat hepatic DNA. (2009) (7)
Inhibition by a peri-fluorine atom of 1,2-dihydrodiol formation as a basis for the lower tumorigenicity of 12-fluoro-5-methylchrysene than of 5-methylchrysene. (1984) (7)
Carcinogen-derived biomarkers and lung cancer. (1996) (7)
Resolution and quantitation of mercapturic acids derived from crotonaldehyde, methacrolein, and methyl vinyl ketone in the urine of smokers and non-smokers. (2020) (7)
Quantitation of DNA Adducts Resulting from Acrolein Exposure and Lipid Peroxidation in Oral Cells of Cigarette Smokers from Three Racial/Ethnic Groups with Differing Risks for Lung Cancer. (2022) (7)
Analysis of the benzene oxide-DNA adduct 7-phenylguanine by liquid chromatography-nanoelectrospray ionization-high resolution tandem mass spectrometry-parallel reaction monitoring: application to DNA from exposed mice and humans. (2014) (7)
Evolution of research on the DNA adduct chemistry of N-nitrosopyrrolidine and related aldehydes. (2011) (7)
Methylchrysenes as Probes for the Mechanism of Metabolic Activation of Carcinogenic Methylated Polynuclear Aromatic Hydrocarbons. (1986) (7)
N-nitroso-N-methyloctadecylamine in hair-care products. (1983) (7)
Transcriptome profiling in oral cavity and esophagus tissues from (S)‐N′‐nitrosonornicotine‐treated rats reveals candidate genes involved in human oral cavity and esophageal carcinogenesis (2016) (7)
Tobacco smoke toxicant and carcinogen biomarkers and lung cancer susceptibility in smokers (2016) (7)
Study of chemical carcinogenesis. 22. Synthesis of dihydro diols as potential proximate carcinogens of benzofluoranthenes (1981) (7)
Effects of 6-nitro substitution on 5-methylchrysene tumorigenicity, mutagenicity and metabolism. (1986) (7)
Synthesis of anti-7,8-dihydroxy-9,10-epoxy-7,8,9, 10-tetrahydro-11-methylbenzo[a]pyrene and its reaction with DNA. (1999) (7)
Applying Tobacco, Environmental, and Dietary-Related Biomarkers to Understand Cancer Etiology and Evaluate Prevention Strategies (2020) (6)
A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s. (2017) (6)
Modulation of benzo[a]pyrene-DNA adducts in hamster cheek pouch by chronic ethanol consumption. (1990) (6)
Oral dosing of dihydromethysticin ahead of tobacco carcinogen NNK effectively prevents lung tumorigenesis in A/J mice. (2020) (6)
Formation of 7-(4-oxobutyl)guanine in hepatic DNA of rats treated with N-nitrosopyrrolidine. (1992) (6)
Effects of fluorine substitution on the DNA binding and tumorigenicity of benzo[b]fluoranthene in mouse epidermis. (1989) (6)
GRAS 29 flavoring substances (2020) (6)
CARCINOGEN-DNA ADDUCTS ARE INCREASED IN THE EXFOLIATED UROTHELIAL CELLS OF WIVES OF SMOKERS: BIOLOGICAL MONITORING OF PASSIVE SMOKE EXPOSURE (2004) (6)
Comparative mouse skin tumorigenicity and induction of Ha-ras mutations by bay region diol epoxides of 5-methylchrysene and 5,6-dimethylchrysene. (1998) (6)
Investigation of 2'-Deoxyadenosine-Derived Adducts Specifically Formed in Rat Liver and Lung DNA by N'-Nitrosonornicotine Metabolism. (2021) (6)
Differences in conformations of covalent adducts derived from the binding of 5- and 6-methylchrysene diol epoxide stereoisomers to DNA. (1990) (6)
Laboratory studies on snuff-dipping and oral cancer (1986) (6)
Identification of an N'-Nitrosonornicotine-Specific Deoxyadenosine Adduct in Rat Liver and Lung DNA. (2021) (6)
Metabolism of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone by cultured monkey lung explants. (2000) (6)
Comparative metabolism and DNA binding of 6-nitro-5-methylchrysene and 5-methylchrysene. (1987) (6)
GRAS Flavoring Substances 25. The 25th publication by the Expert Panel of the Flavor and Extract Manufacturers Association provides an update on reent progress in the consideration of flavoring ingredients generally recognized as safe under the Food Additives Amendment (2011) (6)
Stereochemical assignment of (E)- and (Z)-2-(1-naphthyl)-1-phenylpropene and their photocyclization to 5-methylchrysene (1978) (6)
Mass spectrometric quantitation of apurinic/apyrimidinic sites in tissue DNA of rats exposed to tobacco-specific nitrosamines and in lung and leukocyte DNA of cigarette smokers and non-smokers. (2020) (6)
Coexposure to Inhaled Aldehydes or Carbon Dioxide Enhances the Carcinogenic Properties of the Tobacco-Specific Nitrosamine 4-Methylnitrosamino-1-(3-pyridyl)-1-butanone in the A/J Mouse Lung. (2021) (6)
A Randomized Clinical Trial of Snus Examining the Effect of Complete Versus Partial Cigarette Substitution on Smoking-Related Behaviors, and Biomarkers of Exposure. (2019) (6)
Chemical biomarkers of exposure and early damage from potentially carcinogenic airborne pollutants (2019) (6)
Mammary carcinogenicity of diol epoxide metabolites of benzo[j]fluoranthene in female CD rats. (1996) (6)
Methyl DNA Phosphate Adduct Formation in Lung Tumor Tissue and Adjacent Normal Tissue of Lung Cancer Patients. (2019) (6)
Comparison of microsomal inducer pretreatment on the in vitro alpha-hydroxylation and mutagenicity of N-Nitrosopyrrolidine in rat and hamster liver. (1982) (6)
Biomarkers of Exposure among USA Adult Hookah Users: Results from Wave 1 of the Population Assessment of Tobacco and Health (PATH) Study (2013–2014) (2020) (5)
Chemical carcinogenesis: an overview. (1985) (5)
N-ethyl-N-nitrosourea induced brain tumors in rats monitored by nuclear magnetic resonance imaging, plasma proton nuclear magnetic resonance spectroscopy and microscopy. (1992) (5)
Cigarette Smoking Enhances the Metabolic Activation of the Polycyclic Aromatic Hydrocarbon Phenanthrene in Humans. (2020) (5)
3-(2-Deoxy-.beta.-D-erythropentofuranosyl)-6,7-dihydro-6,7-dihydroxyimidazo[1,2-a]purin-9(3H)-one, a major deoxyguanosine adduct formed from a novel diazo hydroxide product of .alpha.-hydroxylation of the carcinogen N-nitrosomorpholine. (1986) (5)
Quantification of 4-hydroxy-1-(3-pyridyl)-1-butanone released from human haemoglobin as a dosimeter for exposure to tobacco-specific nitrosamines. (1991) (5)
Chemical Carcinogens: In Vitro Metabolism and Activation (1981) (5)
Changes in Biomarkers of Tobacco Exposure among Cigarette Smokers Transitioning to ENDS Use: The Population Assessment of Tobacco and Health Study, 2013–2015 (2022) (5)
Carcinogen Metabolites as Biomarkers (2008) (5)
Carcinogenic Effects of Cigarette Smoke on the Respiratory Tract (2010) (5)
Inhibition of tobacco-specific nitrosamine 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumors and DNA methylation in F344 rats and A/J mice by phenethyl isothiocyanate. (1990) (5)
Harmonization of acronyms for volatile organic compound metabolites using a standardized naming system. (2021) (5)
Tumorigenicity of Fjord Region Diol Epoxides of Polycyclic Aromatic Hydrocarbons (1996) (5)
Evidence that a hemoglobin adduct used for dosimetry of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone is a carboxylic ester. (1993) (5)
Analysis of syn- and anti-1,2-dihydroxy-3,4-epoxy-1,2,3,4-tetrahydro-5-methylchrysene -deoxyribonucleoside adducts by boronate chromatography. (1985) (5)
Mechanistic studies of tobacco carcinogenesis in mouse epidermis and lung tissues. (1989) (5)
Synthesis and tumor-initiating activities of dimethylchrysenes. (1988) (5)
Identification of metabolites of 5,11-dimethylchrysene and 5,12-dimethylchrysene and the influence of a peri-methyl group on their formation. (1982) (5)
Liquid Chromatography–Electrospray Ionization–Tandem Mass Spectrometry Quantitation of Urinary [Pyridine-D4]4-hydroxy-4-(3-pyridyl)butanoic Acid, a Biomarker of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone Metabolic Activation in Smokers (2014) (5)
Metabolic Activation of Chrysene by Human Hepatic and Pulmonary Cytochrome P450 Enzymes (1996) (4)
No association between smoking and the presence of tobacco-specific nitrosamine metabolites in ovarian follicular fluid. (2002) (4)
Abstract LB-63: (S)-N′-nitrosonornicotine, a constituent of smokeless tobacco, is a potent oral tumorigen in rats (2012) (4)
Chemical Studies on Tobacco Smoke-LIV Determination of Hydroxybenzyl Alcohols and Hydroxyphenyl Ethanols in Tobacco and Tobacco Smoke (1978) (4)
N-nitroso compounds and man: sources of exposure, endogenous formation and occurrence in body fluids. (1998) (4)
Anthocyanins and Cancer Prevention (2012) (4)
Anticarcinogenesis by isothiocyanates, indole-3-carbinol, and Allium thiols. (2000) (4)
Metabolism of the tobacco specific nitrosamines, N'-nitrosonornicotine and 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone. (1980) (4)
Reactions of alpha-acetoxy-N-nitrosopyrrolidine with deoxyguanosine and DNA. (2001) (4)
Chromatographic conditions for separation of 32P-labeled phosphates of major polynuclear aromatic hydrocarbon--deoxyribonucleoside adducts. (1989) (4)
Contamination of deconjugation enzymes derived from Helix pomatia with the plant bioactive compounds 3,3'-diindolylmethane, 5-methoxypsoralen, and 8-methoxypsoralen. (2013) (4)
Identification and analysis of a mercapturic acid conjugate of indole-3-methyl isothiocyanate in the urine of humans who consumed cruciferous vegetables. (2018) (4)
Erratum: Carcinogenicity studies of inhaled cigarette smoke in laboratory animals: Old and new (Carcinogenesis (2005) vol. 26 (1488-1492)) (2005) (4)
Effects of immediate versus gradual nicotine reduction in cigarettes on biomarkers of biological effects. (2019) (4)
Urinary Nicotine Metabolites and Self-Reported Tobacco Use Among Adults in the Population Assessment of Tobacco and Health (PATH) Study, 2013-2014. (2022) (4)
On the metabolic activation of N-nitrosomorpholine and N'-nitrosonornicotine: effects of deuterium substitution. (1982) (4)
Re: Foulds and Ramstrom: Cancer Causes and Control 17: 227–228 (2006) and Henley et al., Cancer Causes and Control 16: 347–358 (2005). How Smokeless Tobacco can Cause Lung Cancer (2006) (4)
Identification and quantification of phenanthrene ortho-quinones in human urine and their association with lipid peroxidation. (2020) (4)
Transannular carbene reactions: An intermediate organic laboratory experiment (1971) (4)
Quantitation of phenanthrene dihydrodiols in the urine of smokers and non-smokers by gas chromatography-negative ion chemical ionization-tandem mass spectrometry. (2020) (4)
Increased Levels of the Acrolein Metabolite 3-Hydroxypropyl Mercapturic Acid in the Urine of e-Cigarette Users. (2022) (3)
Tobacco carcinogenesis: Mechanisms and biomarkers (2010) (3)
Tackling the real issues (2011) (3)
FEMA GRAS assessment of natural flavor complexes: Asafetida oil, garlic oil and onion oil. (2023) (3)
Evidence for metabolic alpha hydroxylation of N-nitrosopyrrolidine. (1978) (3)
A sensitive new method for the detection of N-nitrosomorpholine formation in vivo. (1984) (3)
Re: Cigar smoking in men and risk of death from tobacco-related cancers. (2000) (3)
Biomarkers of Exposure and Potential Harm among Natural American Spirit Smokers. (2019) (3)
Metabolism and DNA adduct formation of carcinogenic tobacco-specific nitrosamines found in smokeless tobacco products (2020) (3)
Tobacco SpecificN-Nitrosamines: Occurrence, Carcinogenicity, and Metabolism (1979) (3)
5 – On the Carcinogenicity of 5-Methylchrysene: Structure–Activity Studies and Metabolism (1978) (3)
Alpha-hydroxylation of N-nitrosopyrrolidine and N'-nitrosonornicotine by human liver microsomes. (1979) (3)
ED01.02 Tobacco Carcinogens and Lung Cancer Susceptibility (2017) (3)
The formation of azoxy-2-phenylethane during the biological oxidation of phenylethylamine by rabbit liver microsomes. (1981) (3)
Comparative carcinogenicity and metabolism of the tobacco specific carcinogens, NNN and NNK (1979) (3)
Metabolism of K-region derivatives of 1-nitropyrene by rat liver in vitro. (1988) (3)
Molecular modelling of CYP2A enzymes: application to metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) (2004) (3)
Reducing harm caused by tobacco. Research findings from the University of Minnesota. (2005) (3)
Alkylation of metal derivatives of 1,3-diphenyl-1,3-propanedione with 1,2-diphenyl-3,3-dichlorocyclopropene (1970) (3)
Formation of Tobacco-Specific Nitrosamines: Carcinogenicity and Role of Dietary Fat in Their Carcinogenicity (1994) (3)
Cigarette Smokers Versus Cannabis Smokers Versus Co-users of Cigarettes and Cannabis: A Pilot Study Examining Exposure to Toxicants. (2021) (3)
A STUDY OF CHEMICAL CARCINOGENESIS. II. SYNTHESIS OF N-NITROSAMINO ALDEHYDES (1976) (2)
Unwinding and hydrodynamic flow linear dichroism characteristics of supercoiled DNA covalently modified with two isomeric methylchrysene diol epoxides of different biological activities. (1993) (2)
Quantitative analysis of 3'-hydroxynorcotinine in human urine. (2015) (2)
Assays for metabolic alpha-hydroxylation of N'-nitrosonornicotine and N-nitrosopyrrolidine and the influence of modifying factors. (1980) (2)
II.2.d Tobacco-specific nitrosamines in tobacco and tobacco smoke. (1983) (2)
Large Differences in Urinary Benzene Metabolite S-Phenylmercapturic Acid Quantitation: A Comparison of Five LC-MS-MS Methods. (2020) (2)
Expression of a 32 kDa protein in rat mammary tumors induced by anti‐benzo[c]phenanthrene‐3,4‐diol‐1,2‐epoxide (1996) (2)
DNA damage in human oral cells induced by use of e-cigarettes. (2022) (2)
Assay for microsomal alpha-hydroxylation of N'-nitrosonornicotine and determination of the deuterium isotope effect for alpha-hydroxylation. (1979) (2)
Synthesis of N-(purin-8-yl)arylamines. (1993) (2)
Metabolism of 1-Nitro [ U-4 , 5 , 9 , 10-14 C ] pyrene in the F 344 Rat 1 (2006) (2)
Quantitation of Microsomal a-Hydroxylation of the Tobacco-specific Nitrosamine , 4-( Methylnitrosamino )-l-( 3-pyridyl )-l-butanone 1 (2006) (2)
Metabolism of benzo[a]pyrene and 7 beta,8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a pyrene in lung and liver of newborn mice. (1989) (2)
Reactions of Isopropenyl Stearate with Diethyl Malonate, Acetoacetic Ester, and Related Keto Esters. Enol Esters. XVII (1973) (2)
Interaction of CYP 1 B 1 , cigarette-smoke carcinogen metabolism , and lung cancer risk (2010) (2)
Abstract 1690: Analysis of benzo[a]pyrene and phenanthrene tetraol enantiomers in human urine: Relevance to the bay region diol epoxide hypothesis of benzo[a]pyrene carcinogenesis and to biomarker studies (2010) (2)
Products Obtained by in Vitro Reaction of 4, 5-Epoxy-4, 5-Dihydro-1-Nitropyrene with DNA (1990) (2)
Ident Â¡ficaiion and Quantitative Determination of Aniline and Toluidines in Human Urine1 (2006) (2)
A Study of Chemical Carcinogenesis. Part 84. Synthesis and Fluorescence Spectra of Structural Analogues of Potential Benzo[b]fluoroanthene-DNA Adducts. (1986) (2)
Abstract 4347: A randomized phase 2 clinical trial of PEITC on detoxification of tobacco-specific and non-specific carcinogens and toxicants (2016) (2)
INFLUENCE OF MODIFIERS OF MFO ACTIVITY ON THE IN VITRO METABOLISM OF CYCLIC NITROSAMINES (1980) (2)
Carcinogenicity, metabolism and DNA binding of the tobacco specific nitrosamine, 4-(methylnitrosamino)-1-3(3-pyridyl)-1-butanone (NNK) (1981) (2)
Correction to Effects of smoking cessation on eight urinary tobacco carcinogen and toxicant biomarkers (Chemical Research Toxicology (2009) 22, (734-741) DOI: 10.0121/tx800479s) (2012) (2)
Abstract 4652: Urinary levels of the tobacco-specific carcinogen N′-nitrosonornicotine and its glucuronide are strongly associated with esophageal cancer risk in smokers in the Shanghai Cohort Study (2011) (2)
Polycyclic Aromatic Hydrocarbon Biomarker Levels among Smokers who Switch to Oral Nicotine (2017) (2)
Erratum: Similar uptake of lung carcinogens by smokers of regular, light, and ultralight cigarettes (Cancer Epidemiology Biomarkers and Prevention (March 2005) 14 (693-698)) (2006) (2)
Metabolic alpha-hydroxylation of the tobacco-specific carcinogen, N'-nitrosonornicotine. (1978) (2)
Reaction of hydrazine with 1,2-diphenyi-3-dibenzoylmethylenecyclopropene and 1,2-diphenyl-3-diacetylmethylenecyclopropene; formation of pyridazines (1972) (2)
ON THE ENHANCING EFFECT OF A BAY-REGION METHYL GROUP IN 5-METHYLCHRYSENE CARCINOGENESIS. (1983) (2)
Structure-Activity Relationships for Inhibition of 4-(Methylnitrosamino)-l-(3- pyridyl)-l-butanone Lung Tumorigenesis by Arylalkyl Isothiocyanates in A/J Mice1 (2006) (2)
FEMA GRAS assessment of natural flavor complexes: Allspice, anise, fennel-derived and related flavoring ingredients. (2023) (2)
Fate of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in pregnant and newborn C57BL mice. (1984) (2)
High pressure liquid chromatographic assay for alpha hydroxylation of N-nitrosopyrrolidine by isolated rat liver microsomes. (1978) (2)
A Study of Chemical Carcinogenesis. Part 104. A Study of Reactions of α,β-Unsaturated Carbonyl Compounds with Deoxyguanosine. (1988) (2)
Thirty day multiple dose administration of PEITC A phase I study with steady state pharmacokinetics showing good tolerance through 120 mg daily (2001) (2)
Nicotine-derived JV-Nitrosamines and Tobacco-related Cancer: Current Status and Future Directions1 (2006) (1)
Original Article Interaction of CYP1B1, cigarette-smoke carcinogen metabolism, and lung cancer risk (2010) (1)
Inhibition of lung tumorigenesis in A/J mice by combinations of N-acetyl-S-(N-2-phenethylthiocarbamoyl)-L-cysteine, myo-inositol, indole-3-carbinol, or diindolylmethane (2007) (1)
Smokeless tobacco and its constituents (2019) (1)
On the metabolic activation of 5-nitroacenaphthene (1981) (1)
Metabolism in the F 344 Rat of 4-( W-Methyl-A /-nitrosamino )-1-( 3-pyridyl )-1 butanone , a Tobacco-specific Carcinogen 1 (2006) (1)
Human Phenanthrene Metabolites as Probes for the Metabolic Activation and Detoxification of Carcinogenic Polycyclic Aromatic Hydrocarbons (2008) (1)
Development of liquid chromatograpy electrospray ionization tandem mass spectrometry methods for analysis of DNA adducts of formaldehyde and their application to rats treated with N-nitrosodimethylamine or 4-(methylnitrosamino) -1-(3-pyridyl)-1-butanone (Chemical Research in Toxicology (2007) 20, 8, (2008) (1)
Detection of 06-Methyldeoxyguanosine in Human Placental DNA1'2 (2006) (1)
Synthesis of 4‐amino‐3,2′ ‐dimethylbiphenyl‐3‐methyl‐14C and 4‐amino‐2′‐methylbiphenyl‐2′‐methyl‐14C (1981) (1)
O-300 Phase I chemoprevention trial of oltipraz in smokers (2003) (1)
Chemoprevention by phytochemical modifiers of carcinogen metabolism (2000) (1)
Cleavage of saturated fatty acid amides by anhydrous hydrogen fluoride-boron trifluoride (1973) (1)
Inhibition of target tissue activation of N'-nitrosonornicotine and N-nitrosopyrrolidine by dietary components. (1984) (1)
Reactions of N-nitrosomorpholine metabolites with deoxyguanosine and DNA (1985) (1)
Tobacco smoke and its constituents (2019) (1)
Chemical Research in Toxicology Editorial Advisory Board Members' Favorite CRT Articles. (2016) (1)
Smokeless tobacco—proposals for regulation (2010) (1)
A Study of Chemical Carcinogenesis. Part 109. Oxidation of Polynuclear Aromatic Hydrocarbons with Ceric Ammonium Sulfate: Preparation of Quinones and Lactones. (1988) (1)
Study of Chemical Carcinogenesis. Part 91. Reactions with Deoxyguanosine of 4-(Carbethoxynitrosamino)-1-(3-pyridyl)-1-butanone, a Model Compound for α-Hydroxylation of Tobacco-Specific Nitrosamines. (2002) (1)
Quantitative Analysis of Alkyl-2-hydroxy-2-cyclopenten-1-ones in Tobacco Smoke (1981) (1)
SPECIAL ARTICLE Tobacco Addiction: Implications for Treatment and Cancer Prevention (1997) (1)
Abstract LB-405: Modulation of the metabolism of air-borne pollutants by broccoli sprout beverages: Results of a short term, cross-over clinical trial in Qidong, People's Republic of China (2011) (1)
Abstract 4698: Preferential glutathione conjugation of a reverse diol epoxide compared to a bay region diol epoxide of benzo[a]pyrene in human hepatocytes: Relevance to glutathione-S-transferase genotyping in epidemiology studies (2010) (1)
Association of urinary biomarkers of smoking-related toxicants with lung cancer incidence in smokers: The Multiethnic Cohort Study. (2022) (1)
A New Editorial Team for CRT. (2018) (1)
3-(2-Deoxy-β-D-erythropentofuranosyl)-6,7-dihydro-6,7-dihydroxyimidazo(1,2# -a)purin-9(3H)-one, a Major Deoxyguanosine Adduct Formed from a Novel Diazo Hydroxide Product of α-Hydroxylation of the Carcinogen N-Nitrosomorpholine. (1987) (1)
Environmental carcinogenesis and its prevention: the head and neck cancer model. (1993) (1)
Quantitation by liquid chromatography-nanoelectrospray ionization-high resolution tandem mass spectrometry of DNA adducts derived from methyl glyoxal and carboxyethylating agents in leukocytes of smokers and non-smokers. (2020) (1)
GRAS 27 flavoring substances (2015) (1)
Relevance of Nicotine-Derived N-Nitrosamines in Tobacco Carcino-Genesis (1991) (1)
Effects of Ethanol Consumption on the Metabolism and Carcinogenicity of N′‐Nitrosonornicotine in F344 Rats a (1984) (1)
Synthesis of carbon‐14 labeled 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (1985) (1)
On the metabolic activation of the environmental carcinogens benzo(j)fluoroanthene and benzo(b)fluoranthene (1979) (1)
Abstract B89: Child second-hand and third-hand exposure to carcinogens and tobacco toxicants (2010) (1)
A tobacco-specific lung carcinogen: From basic research to tobacco control. (2006) (1)
FEMA GRAS assessment of derivatives of basil, nutmeg, parsley, tarragon and related allylalkoxybenzene-containing natural flavor complexes. (2023) (1)
Mass Spectrometric Quantitation of N'-Nitrosonornicotine-1N-oxide in the Urine of Cigarette Smokers and Smokeless Tobacco Users. (2022) (1)
Approaches to the development of assays for interaction of tobacco-specific nitrosamines with haemoglobin and DNA. (1988) (0)
Mechanisms and Biomarkers of Tobacco Carcinogenesis (2022) (0)
Effects of catechol on the metabolism and DNA-binding of [3H]benzo(a)pyrene in mouse skin in vivo (1985) (0)
Distinct conformers of alkylchrysene diol epoxide-deoxyguanosine adducts detected by proton NMR. (1992) (0)
Advances in Brief Stereochemistry of Metabolites of a Tobacco-specific Lung Carcinogen in Smokers ’ Urine 1 (1999) (0)
Evidence That a Hemoglobin Adduct (2016) (0)
Effects of Chronic Ethanol Consumption on Benzo ( a ) pyrene Metabolism and Glutathione S-Transferase Activities in Syrian Golden Hamster Cheek Pouch and Liver 1 (2006) (0)
Nasal cavity carcinogens: Possible routes of metabolic activation (2017) (0)
Dietary Phenethyl Isothiocyanate Adduct Formation and Tumorigenicity in the Lung of F 344 Rats 4-( Methylnitrosamino )-1-( 3-pyridyl )-1-butanone-induced DNA Inhibition of Updated (2006) (0)
50 Years of Research on Tobacco-Specific Nitrosamines: A Virtual Collection of Emerging Knowledge of Chemical Toxicology of Tobacco and Nicotine Delivery Systems and Call for Contributions to a Landmark Special Issue. (2022) (0)
Abstract 4639: Effects of defined amounts of alcohol consumption on levels of N2-ethylidene-dGuo in DNA from human buccal cells and peripheral blood nucleated cells (2011) (0)
An approach to the evaluation of berries for cancer prevention with emphasis on esophageal cancer (2014) (0)
Organization TobReg proposal smoke: a description of the World Health Mandated lowering of toxicants in cigarette (2008) (0)
Response to: Causal effects of smokeless tobacco on mortality in CPS-I and CPS-II. by Foulds J et al. Commentary (2006) (0)
Abstract CN06-01: Induction of oral cavity cancer in rats by (S)-N'-nitrosonornicotine, a constituent of smokeless tobacco (2012) (0)
Inhibition by a pen-Fluorine Atom of 1 , 2-Dihydrodiol Formation as a Basis for the Lower Tumorigenicity of 12-Fluoro-5-methy Ichrysene than of 5-Methylchrysene 1 (2006) (0)
Null Results in Brief Null Association between Frequency of Cured Meat Consumption and Methylvaline and Ethylvaline Hemoglobin Adduct Levels : The N-Nitroso Brain Cancer Hypothesis 1 (2002) (0)
A Special Issue of CRT: Celebrating Volume 30. (2017) (0)
SYNTHESIS OF DIHYDRO DIOLS AS POTENTIAL PROXIMATE CARCINOGENS OF BENZOFLUORANTHENES. A STUDY OF CHEMICAL CARCINOGENESIS. PART 22. (1981) (0)
Modification of deoxyguanosine via α-hydroxylation of N-nitrosopyrrolidine (1982) (0)
Hecht smoke studies of human exposure to secondhand tobacco Carcinogen derived biomarkers : applications in (2004) (0)
Abstract 4695: Elevated levels of biomarkers of volatile organic carcinogens and toxicants in Chinese women who regularly cook at home (2010) (0)
Abstract 4152: Differences in nicotine metabolism among five racial/ethnic groups with disparate risks for lung cancer: The multiethnic cohort study (2014) (0)
Preparation of a Beverage Containing Freeze-Dried Watercress for a Clinical Trial of Carcinogen and Toxicant Detoxification. (2021) (0)
IV.6 HPLC-TEA of tobacco-specific nitrosamines. (1983) (0)
STRUCTURE-MUTAGENICITY RELATIONSHIPS OF N-OXIDIZED DERIVATIVES OF ANILINE, O-TOLUIDINE, 2′-METHYL-4-AMINOBIPHENYL, AND 3,2′-DIMETHYL-4-AMINOBIPHENYL. PART 17 OF “A STUDY OF CHEMICAL CARCINOGENESIS” (1980) (0)
Obituary for Rolf Preussmann (1928–2012) (2013) (0)
Formation of Cyclic 1 , / V 2-Propanodeoxyguanosine Adducts in DMA upon Reaction with Acrolein or Crotonaldehyde 1 2 (2006) (0)
Effects of Chronic Ethanol Consumption on the Metabolism and Carcinogenicity of W-Nitrosonornicotine in F344 Rats1 (2006) (0)
Contributions — D: Anticarcinogenic Factors (2006) (0)
Abstract 1696: Metabolism of (S)-NNAL and (R)-NNAL in the isolated perfused rat lung system (2010) (0)
Abstract 667: Evaluation of toxicant exposure in U.S. smokers after short-term switching to commercial low-nitrosamine cigarettes (2012) (0)
Reductionof Tumorigenicityand of DihydrodiolFormation by Fluorine Substitutionin the Angular Ringsof Dibenzo(a,/)pyrene1 (1981) (0)
Abstract 4650: Nornicotine nitrosation in human saliva and its relation to endogenous formation of N′-nitrosonornicotine in oral nicotine replacement therapy users (2011) (0)
Reviews and comment from the nature publishing group (2003) (0)
Identification of frans- 1,2-Dihydro-1,2-dihydroxy-6-nitrochrysene as a Major Mutagenic Metabolite of 6-Nitrochrysene1 (2006) (0)
Isothiocyanates inhibit lung tumorigenesis (1991) (0)
Detection of Polynuclear Aromatic Hydrocarbon Diol Epoxide-Derived DNA and Globin Adducts in Humans by Gas Chromatography-Mass Spectrometry (1996) (0)
Richard Loeppky (1937-2012). (2012) (0)
Abstract A19: Interactions between tobacco smoke chemicals in rodent tumor models (2020) (0)
Esophageal carcinogenesis with N' nitrosonornicotine and dinitrosopiperazine, modified by vitamin A or enzyme inducers (1975) (0)
Characterization and quantitation of busulfan DNA adducts in the blood of patients receiving busulfan therapy (2023) (0)
Synthesis of Potential Phenolic Metabolites of Benzo[b]fluoranthene. (1986) (0)
Induction of Lung and Exocrine Pancreas Tumors in F344 Rats by Tobacco-specific and /irara-derived TV-Nitrosamines1'2 (2006) (0)
Lactols in hydrolysates of DNA treated with alpha-acetoxy-N-nitrosopyrrolidine or crotonaldehyde. (1998) (0)
N' Nitrosonornicotine: presence and origin in tobacco and carcinogenicity in rats (1975) (0)
Nitrosamine risks [3] (multiple letters) (1980) (0)
Abstract 4656: Relationship of nicotine and carcinogen biomarkers to lung cancer risk among smokers in the Shanghai cohort study (2011) (0)
Tobacco Use and Cancer (2005) (0)
Quantitation by Liquid Chromatography-Nanoelectrospray Ionization-High-Resolution Tandem Mass Spectrometry of Multiple DNA Adducts Related to Cigarette Smoking in Oral Cells in the Shanghai Cohort Study. (2023) (0)
Abstract A6: Urinary levels of volatile organic carcinogens and toxicant biomarkers in relation to lung cancer development in both smokers and nonsmokers: The Shanghai Cohort Study (2011) (0)
Contrasting Disposition and Metabolism of Topically Applied Benzo(a)pyrene, fraiw-7,8-Dihydroxy-7,8-dihydrobenzo(fl)pyrene, and 7/o,8a-Dihydroxy-9a, 1Oa-epoxy-7,8,9,10-tetrahydrobenzo(fl)pyrene Â¡nMouse Epidermis in Vivo1 (2006) (0)
Quantitation of Acetaldehyde-DNA Adducts: Biomarkers of Alcohol Consumption (2014) (0)
Pyridyloxobutyl, pyridylhydroxybutyl and methyl DNA phosphate adduct formation in rats due to metabolic activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (2018) (0)
Vaccine Trials Show Activity in Kidney and Lung Cancer (2004) (0)
Abstract 4791: Development of a high resolution mass spectrometry method for the observation and characterization of unknown adducts in human DNA (2012) (0)
Abstract 4595: The impact of CYP2A6 genetic polymorphisms on nicotine metabolism and lung cancer risk in two prospective cohorts of smokers (2015) (0)
Biomarkers for Assessment of Chemical Exposures From e-Cigarette Emissions (2017) (0)
Evaluation of Cysteine Adduci Formation in Rat Hemoglobin by 4-(Methyl-nitrosamino)-l-(3-pyridyl)-l-butanone and Related Compounds1 (2006) (0)
Abstract 2758: Genetic variability in tobacco-specific nitrosamine NNK to NNAL metabolism (2011) (0)
1065 Anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE), a carcinogenic metabolite of Benzo[a]pyrene (BP), alters intracellular Ca2+ concentrations in human small airway epithelial (SAE) cells (2000) (0)
Cancer-causing agents in new tobacco products (2006) (0)
Toxicology Nicotine-Derived N-Nitrosamines (TSNA) and Their Relevance In Tobacco Carci nogenesis (1991) (0)
Synthesis and sequence preference of acetaldehyde-derived oligonucleotide interstrand cross-link (2004) (0)
TOBACCOCONTROL42192 44..48 (0)
Abstract 3167: Comparison of the pharmacokinetics of phenanthrene in smokers after oral ingestion or inhalation through cigarettes for potential lung cancer susceptibility assessment (2011) (0)
Abstract 4697: Liquid chromatography-electrospray ionization tandem mass spectrometry analysis of 7-ethylguanine in human urine (2010) (0)
Direct Synthesis and Characterization of Site-Specific Deoxyguanosyl and Deoxyadenosyl Adducts Derived from the Binding of Pah Diol Epoxides to Oligonucleotides (1996) (0)
Abstract A41: Assessing the effect of glucobrassicin-rich Brussels sprouts on the metabolism of deuterated phenanthrene: Developing food-based chemoprevention of tobacco-related lung cancer (2020) (0)
Urine of Elementary School-aged Children Metabolites of a Tobacco-specific Lung Carcinogen in the (2001) (0)
Experimental nasal cavity tumors induced by tobacco-specific nitrosamines (TSNA) (2017) (0)
Reviews and comment from the nature publishing group (2003) (0)
Abstract A69: Pilot study of the effects of indole-3-carbinol on deuterated phenanthrene metabolism in smokers (2012) (0)
Continuing excellence for chemical research in toxicology. (2013) (0)
Advances in Brief Metabolites of the Tobacco-specific Nitrosamine 4-( Methylnitrosamino )-l-( 3-pyridyl )-l-butanone in Smokers ' Urine 1 (2006) (0)
MODEL FOR CANCER PREVENTION STRATEGIES* OF TOBACCO-SPECIFIC NITROSAM INES-A (1994) (0)
Abstract 1502: Urinary biomarkers of polycyclic aromatic hydrocarbon and volatile organic carcinogens in relation to lung cancer development in lifelong never smokers - The Shanghai Cohort Study. (2013) (0)
FRONT MATTER (2022) (0)
Syntheses of anti-7,8,9,10-Tetrahydro-11-, and 12-Methylbenzo[A]Pyrene-7,8-DIOL-9, 10-Epoxides: Identification and Comparison of DNA Adduct Formation with Calf-Thymus DNA in vitro (1999) (0)
Analysis of Multiple Biomarkers Using Structural Equation Modeling. (2020) (0)
Tumor-initiating Activity of Fluorinated 5-Methylchrysenes 1 (2006) (0)
Title Effect of immediate vs gradual reduction in nicotine content of cigarettes on biomarkers of smoke exposure a randomized clinical trial (2018) (0)
Molecular basis for the structure carcinogenicity relationships of polynuclear aromatic hydro carbons (1983) (0)
Identification of 5-methylchrysene DNA adducts in mouse skin and the influence of a bay region methyl group on their formation (1981) (0)
Correspondence re: C. Chen et al., CYP2D6 genotype and the incidence of anal and vulvar cancer. Cancer Epidemiol. Biomark. Prev., 8: 317-321, 1999. (1999) (0)
Abstract B07: Nasal epithelial gene expression profiles reflect dynamic biological response to smoking cessation (2012) (0)
The organ culture of rat esophageal mucosal epithelium and its response to N'-nitrosonornicotine (1981) (0)
Abstract 863: Urinary levels of a polycyclic aromatic hydrocarbon metabolite in relation to lung cancer development in cigarette smokers of the Shanghai Cohort Study (2010) (0)
Dose-Response Study of DNA and Hemoglobin Adduci Formation by 4-( Methylnitrosamino )-l-( 3-pyridyl )-l-butanone in F 344 Rats 1 (2006) (0)
FEMA GRAS assessment of natural flavor complexes: Lemongrass oil, chamomile oils, citronella oil and related flavoring ingredients (2023) (0)
Dose-Response Study of DNA and Hemoglobin Adduci Formation by 4-(Methylnitrosamino)-l-(3-pyridyl)-l-butanone in F344 Rats1 (2006) (0)
Erratum: N-nitroso compounds and man: Sources of exposure, endogenous formation and occurrence in body fluids (European Journal of Cancer Prevention (June 1998) 7 (244-246)) (1998) (0)
Endovascular therapy of traumatic lesions of the cervicocerebral vasculature (1994) (0)
Transannular Carbene Reactions. (1971) (0)
REACTIONS OF ISOPROPENYL STEARATE WITH DIETHYL MALONATE, ACETOACETIC ESTER, AND RELATED KETO ESTERS, ENOL ESTERS PART 17 (1973) (0)
Enhanced mutagenicity and metabolism of nitropyrrolidine by liver microsomes isolated from ethanol consuming hamsters (1978) (0)
Abstract 4651: Analysis of 3,3′-diindolylmethane in urine after consumption of cruciferous vegetables in the Singapore Cohort Study (2011) (0)
Clinical and Biochemical Studies Support Smokeless Tobacco'sCarcinogenicPotential in theHumanOralCavity (2013) (0)
CYP 2 D 6 Genotype and the Incidence of Anal and Vulvar Cancer . Cancer Epidemiol . Biomark . Prev . , 8 : 317 – 321 , 1999 (1999) (0)
Abstract A49: Chemoprevention of esophageal cancer using PCA, a metabolite of black raspberry-derived anthocyanins (2012) (0)
Quantitation of N-acetyl-S-(9,10-dihydro-9-hydroxy-10-phenanthry)-L-cysteine (Phe-epoxide-NAC) in human urine: comparison with glutathione-S-transferase genotypes. (2006) (0)
Extraction and Metabolism of NNK in the IsolatedPerfused Lung System (2006) (0)
Comparative metabolic activation of 6-methylchrysene and 5-methylchrysene in mouse skin (1985) (0)
1064 The effects of anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE), a carcinogenic metabolite of Benzo[a]pyrene (BP) action on activation of externally regulated kinases 1 and 2 (Erk1/Erk2) in human small airway epithelial (SAE) cells (2000) (0)
Development of a Monoclonal Antibody-based Immunoassay for Cyclic DNA Adducts Resulting from Exposure to Crotonaldehyde 1 (2006) (0)
Synthesis of 5′-Carboxy-N′-nitrosonornicotine and 5′-((14C)Carboxy)-N′-nitrosonornicotine. (1988) (0)
Abstract CN07-02: Polycyclic aromatic hydrocarbon tetraols: Potential phenotypic indicators of lung cancer susceptibility in smokers (2010) (0)
Cigarette reduction: Can it reduce exposure to toxins? (2006) (0)
Abstract A42: The dietary agents indole-3-carbinol and myo-inositol prevent lung cancer induced by vinyl carbamate in A/J mice (2008) (0)
DietaryConsumptionofBlackRaspberriesorTheir Anthocyanin Constituents Alters Innate Immune Cell Traf fi cking in Esophageal Cancer (2015) (0)
Abstract B26: The anti-inflammatory effects of black raspberries and the anthocyanin metabolite protocatechuic acid in N-nitrosomethylbenzylamine-induced esophageal cancer in rats (2012) (0)
Perspective: Tackling the real issues (2011) (0)
Abstract 4030: Nasal gene expression reflects the physiologic response to alternate tobacco products. (2013) (0)
Mass Spectrometry-Based Metabolic Profiling of Urinary Metabolites of N'-Nitrosonornicotine (NNN) in the Rat. (2023) (0)
Special Issue on Tobacco: Chemistry, Mechanisms, Biomarkers and Disease Prevention. (2023) (0)
Mass Spectrometric Analysis of Tobacco-specific Nitrosamine Hemoglobin Adducts in Snuff Dippers, Smokers, and Nonsmokers1 (2006) (0)
P39 Chemoprevention of kava and its potential active components against lung tumorigenesis in A/J mouse induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone and benzo(a)pyrene (2008) (0)
Abstract 2681: Prediagnostic levels of urinary 8-epi-prostaglandin F2αand prostaglandin E2metabolite, biomarkers of oxidative damage and inflammation, and risk of hepatocellular carcinoma (2019) (0)
Immediate Switching to Reduced Nicotine Cigarettes in a U.S.-Based Sample: The Impact on Cannabis Use and Related Variables at 20 Weeks. (2022) (0)
I.3 Problems of contamination and artefact formation in nitrosamine sampling and analysis. (1983) (0)
Hemoglobin Adducts, DNA Adducts, and Urinary Metabolites of Tobacco-Specific Nitrosamines: As Biochemical Markers of Their Uptake and Metabolic Activation in Humans (1994) (0)
Abstract A70: Kava as a lung cancer chemopreventive agent (2010) (0)
Abstract 1689: Liquid chromatography-electrospray ionization-tandem mass spectrometry analysis for 7-carboxymethylguanine and 7-carboxyethylguanine in human liver DNA (2010) (0)
Formation of mutagenic aliphatic azoxy compounds from the corresponding amines by rabbit liver microsomes (1981) (0)
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone Tobacco-specific Nitrosamine, -Hydroxylation of the α Quantitation of Microsomal (2013) (0)
Investigation of the role of alcohol- metabolizing genes and DNA repair genes in the increase of levels of N2-ethylidenedeoxyguanosine (2008) (0)
Absolute configuration of 4-(methylnitrosamino)-1-(3- MTPA esters. The absolute configuration of 4-hydroxy-4-(3- pyridyl)butanoic acid (hydroxy acid) enantiomers were also pyridyl)-1-butanol formed metabolically from assigned based on our original NNAL assignment and therefore (2000) (0)
Effects of Dietary Compounds on a-Hydroxylation of JV-Nitrosopyrrolidine and A/'-Nitrosonornicotine in Rat Target Tissues1 (2006) (0)
Investigation of the presence in human urine of mercapturic acids derived from phenanthrene, a representative polycyclic aromatic hydrocarbon. (2017) (0)
Analysis of total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and r-1,t-2,3,c-4-tetrahydroxy-1,2,3,4-tetrahydrophenanthrene (PheT) in human blood (2006) (0)
Reviews and comment from the nature publishing group (2003) (0)
DNA Damage by Tobacco Carcinogens (2018) (0)
On the carcinogenicity of 5-methylchrysene (1977) (0)
Corrigendum to "Harmonization of acronyms for volatile organic compound metabolites using a standardized naming system" [Int. J. Hygiene Environ. Health 235 (2021) 113749]. (2022) (0)
Comparative Carcinogenicity in A/J Mice and Metabolism by Cultured Mouse Peripheral Lung of AT-Nitrosonornicotine, and Their Analogues1 (2006) (0)
Elevated Urinary 1-HOP, NNN, and NNAL in Smokers with Head and Neck Squamous Cell Carcinoma (2011) (0)
II.2.a General aspects. (1983) (0)
DNA Pyridyloxobutylation: 4-(Acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone Inhibits the Repair ofO6-Methylguanine (1994) (0)
Abstract A01: Lung and pancreatic carcinogenicity and DNA binding of the enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in F344 rats (2013) (0)
Phthalate Mixture Effects on Children with Exacerbation-Prone Asthma in a Study of Multiple Pollutants and Asthma Severity (2020) (0)
A differential proteomics approach to identify proteins involved in lung carcinogenesis induced by a mixture of 4-(methylnitrosoamino)-1-(3-pyridyl)-1-butanone (NNK) and benzo[a]pyrene (BaP) and chemoprevention of indole-3-carbinol (I3C) in A/J mice. (2006) (0)
Introducing Perspectives on Statistical Trends (POST). (2013) (0)
Advances in Brief Potent Mammary Carcinogenicity in Female CD Rats of a Fjord Region Diol-Epoxide of Benzo [ c ] phenanthrene Compared to a Bay Region Diol-Epoxide of Benzo [ a ] pyrene 1 (2007) (0)

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