Stephen T. Smale
#138,902
Most Influential Person Now
Stephen T. Smale's AcademicInfluence.com Rankings
Stephen T. Smalemathematics Degrees
Mathematics
#6589
World Rank
#9100
Historical Rank
Measure Theory
#1447
World Rank
#1812
Historical Rank

Download Badge
Mathematics
Why Is Stephen T. Smale Influential?
(Suggest an Edit or Addition)Stephen T. Smale's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. (1999) (1821)
- The “initiator” as a transcription control element (1989) (1372)
- The RNA polymerase II core promoter. (2003) (1178)
- Association of Transcriptionally Silent Genes with Ikaros Complexes at Centromeric Heterochromatin (1997) (820)
- DNA sequence requirements for transcriptional initiator activity in mammalian cells. (1994) (642)
- Transcription initiation from TATA-less promoters within eukaryotic protein-coding genes. (1997) (576)
- A Unifying Model for the Selective Regulation of Inducible Transcription by CpG Islands and Nucleosome Remodeling (2009) (574)
- A role for Dicer in immune regulation (2006) (560)
- T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer (2005) (538)
- Transcript Dynamics of Proinflammatory Genes Revealed by Sequence Analysis of Subcellular RNA Fractions (2012) (421)
- Selective and antagonistic functions of SWI/SNF and Mi-2beta nucleosome remodeling complexes during an inflammatory response. (2006) (416)
- Transcriptional activation by Sp1 as directed through TATA or initiator: specific requirement for mammalian transcription factor IID. (1990) (388)
- Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: evidence of functional synergy between C/EBP and Rel proteins (1997) (362)
- Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages. (2000) (338)
- Chromatin immunoprecipitation (ChIP). (2009) (307)
- A Prominent Role for Sp1 During Lipopolysaccharide- Mediated Induction of the IL-10 Promoter in Macrophages1 (2000) (305)
- Selective Transcription in Response to an Inflammatory Stimulus (2010) (289)
- Transcriptional Regulation in Eukaryotes: Concepts, Strategies and Techniques (2000) (274)
- Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros (2008) (266)
- Targeting of Ikaros to pericentromeric heterochromatin by direct DNA binding. (2000) (265)
- Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin. (1998) (263)
- Core promoters: active contributors to combinatorial gene regulation. (2001) (257)
- Direct recognition of initiator elements by a component of the transcription factor IID complex. (1994) (248)
- Hierarchies of NF-κB target-gene regulation (2011) (242)
- The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene. (1994) (237)
- LyF-1, a transcriptional regulator that interacts with a novel class of promoters for lymphocyte-specific genes (1991) (205)
- Generality of a functional initiator consensus sequence. (1996) (204)
- Rapid and selective remodeling of a positioned nucleosome during the induction of IL-12 p40 transcription. (1999) (193)
- Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits. (2007) (192)
- Principles of dimer-specific gene regulation revealed by a comprehensive characterization of NF-κB family DNA binding (2011) (186)
- Nucleosome remodeling at the IL-12 p40 promoter is a TLR-dependent, Rel-independent event (2001) (185)
- T-antigen-DNA polymerase alpha complex implicated in simian virus 40 DNA replication (1986) (181)
- Roles of TATA and initiator elements in determining the start site location and direction of RNA polymerase II transcription. (1992) (179)
- Hematopoietic stem cells and lymphoid progenitors express different Ikaros isoforms, and Ikaros is localized to heterochromatin in immature lymphocytes. (1998) (179)
- Transcriptional competence and the active marking of tissue-specific enhancers by defined transcription factors in embryonic and induced pluripotent stem cells. (2009) (175)
- Chromatin structure and gene regulation in the immune system. (2002) (167)
- Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor. (2003) (163)
- Epigenetic characterization of hematopoietic stem cell differentiation using miniChIP and bisulfite sequencing analysis (2007) (162)
- Down-regulation of TDT transcription in CD4(+)CD8(+) thymocytes by Ikaros proteins in direct competition with an Ets activator. (2001) (159)
- Chromatin contributions to the regulation of innate immunity. (2014) (157)
- Restraint of inflammatory signaling by interdependent strata of negative regulatory pathways (2012) (155)
- Pioneer factors, genetic competence, and inductive signaling: programming liver and pancreas progenitors from the endoderm. (2008) (153)
- Dimer‐specific regulatory mechanisms within the NF‐κB family of transcription factors (2012) (152)
- Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA (2018) (147)
- Cross-interference of RLR and TLR signaling pathways modulates antibacterial T cell responses (2012) (138)
- Selectivity of the NF-{kappa}B response. (2010) (136)
- Dynamic assembly of silent chromatin during thymocyte maturation (2004) (135)
- Predominant Interaction of Both Ikaros and Helios with the NuRD Complex in Immature Thymocytes* (2007) (132)
- A Stringent Systems Approach Uncovers Gene-Specific Mechanisms Regulating Inflammation (2016) (132)
- A common mechanism for mitotic inactivation of C2H2 zinc finger DNA-binding domains. (2002) (131)
- Transcription of herpes simplex virus tk sequences under the control of wild-type and mutant human RNA polymerase I promoters (1985) (125)
- Selective dimerization of a C2H2 zinc finger subfamily. (2003) (125)
- Interleukin-10 Inhibits Interleukin-12 p40 Gene Transcription by Targeting a Late Event in the Activation Pathway (2004) (122)
- Pioneer factor interactions and unmethylated CpG dinucleotides mark silent tissue-specific enhancers in embryonic stem cells (2007) (122)
- Core promoter specificities of the Sp1 and VP16 transcriptional activation domains (1995) (121)
- Combinatorial regulation of transcription II: The immunoglobulin mu heavy chain gene. (1995) (119)
- Two distinct promoter elements in the human rRNA gene identified by linker scanning mutagenesis (1986) (116)
- A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation. (2005) (116)
- Mechanism of initiator-mediated transcription: evidence for a functional interaction between the TATA-binding protein and DNA in the absence of a specific recognition sequence. (1993) (110)
- IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure (2018) (109)
- Pten Null Prostate Epithelium Promotes Localized Myeloid-Derived Suppressor Cell Expansion and Immune Suppression during Tumor Initiation and Progression (2014) (109)
- Genome-wide identification of Ikaros targets elucidates its contribution to mouse B-cell lineage specification and pre-B-cell differentiation. (2013) (108)
- C/EBPβ Regulation in Lipopolysaccharide-Stimulated Macrophages (2003) (107)
- Mechanism of synergy between TATA and initiator: synergistic binding of TFIID following a putative TFIIA-induced isomerization. (1997) (99)
- The initiator element: a paradigm for core promoter heterogeneity within metazoan protein-coding genes. (1998) (98)
- Combinatorial regulation of transcription. I: General aspects of transcriptional control. (1995) (97)
- NFIL3 Is a Regulator of IL-12 p40 in Macrophages and Mucosal Immunity (2011) (97)
- Single cell analysis reveals immune cell–adipocyte crosstalk regulating the transcription of thermogenic adipocytes (2019) (92)
- Transcriptional control of inflammatory responses. (2014) (91)
- Transcriptional regulation in the innate immune system. (2012) (88)
- let-7 miRNAs Can Act through Notch to Regulate Human Gliogenesis (2014) (88)
- A Macrophage Response to Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage in Leprosy (2017) (83)
- Splicing kinetics and transcript release from the chromatin compartment limit the rate of Lipid A-induced gene expression. (2013) (83)
- Similar mechanisms for transcription initiation mediated through a TATA box or an initiator element. (1992) (82)
- Similarity between a ubiquitous promoter element in an ancient eukaryote and mammalian initiator elements. (1994) (79)
- Pioneer factors in embryonic stem cells and differentiation. (2010) (76)
- Immune inhibitory ligand CD200 induction by TLRs and NLRs limits macrophage activation to protect the host from meningococcal septicemia. (2010) (74)
- Class-specific Regulation of Pro-inflammatory Genes by MyD88 Pathways and IκBζ* (2008) (73)
- Sp1 activation of a TATA-less promoter requires a species-specific interaction involving transcription factor IID. (1998) (72)
- CIF, an essential cofactor for TFIID-dependent initiator function. (1996) (71)
- Evaluation of the Long‐Term Reconstituting Subset of Hematopoietic Stem Cells with CD150 (2009) (70)
- CIF150, a Human Cofactor for Transcription Factor IID-Dependent Initiator Function (1998) (69)
- Regulation of human ribosomal RNA transcription. (1983) (68)
- The establishment and maintenance of lymphocyte identity through gene silencing (2003) (67)
- A Distal Enhancer in Il12b Is the Target of Transcriptional Repression by the STAT3 Pathway and Requires the Basic Leucine Zipper (B-ZIP) Protein NFIL3* (2011) (65)
- Both LyF-1 and an Ets protein interact with a critical promoter element in the murine terminal transferase gene (1993) (65)
- Beta-galactosidase assay. (2010) (62)
- A potential role for Elf-1 in terminal transferase gene regulation (1996) (60)
- Common Interaction Surfaces of the Toll-Like Receptor 4 Cytoplasmic Domain Stimulate Multiple Nuclear Targets (2003) (58)
- HIV-1 core promoter lacks a simple initiator element but contains a bipartite activator at the transcription start site. (1993) (54)
- Type I and Type II Interferon Coordinately Regulate Suppressive Dendritic Cell Fate and Function during Viral Persistence (2016) (51)
- Toll-Like Receptors Induce Signal-Specific Reprogramming of the Macrophage Lipidome. (2020) (51)
- Dignam and Roeder nuclear extract preparation. (2009) (51)
- Luciferase assay. (2010) (50)
- An Inducible Enhancer Required for Il12b Promoter Activity in an Insulated Chromatin Environment (2007) (50)
- Self‐Renewal of the Long‐Term Reconstituting Subset of Hematopoietic Stem Cells Is Regulated by Ikaros (2009) (49)
- C/EBPbeta regulation in lipopolysaccharide-stimulated macrophages. (2003) (47)
- Opposing roles of Toll-like receptor and cytosolic DNA-STING signaling pathways for Staphylococcus aureus cutaneous host defense (2017) (46)
- Nuclear run-on assay. (2009) (45)
- Ikaros-family proteins: in search of molecular functions during lymphocyte development. (2005) (44)
- Transcription of the lymphocyte-specific terminal deoxynucleotidyltransferase gene requires a specific core promoter structure. (1996) (43)
- Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins (2020) (41)
- Initiator Recognition in a Primitive Eukaryote: IBP39, an Initiator-Binding Protein from Trichomonas vaginalis (2001) (40)
- Experimental strategies for the identification of DNA-binding proteins. (2012) (39)
- Alternative pathway for induction of human immunodeficiency virus gene expression: involvement of the general transcription machinery (1991) (38)
- Differential regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros (2013) (35)
- Transgenic Expression of Helios in B Lineage Cells Alters B Cell Properties and Promotes Lymphomagenesis1 (2005) (35)
- Defined Sensing Mechanisms and Signaling Pathways Contribute to the Global Inflammatory Gene Expression Output Elicited by Ionizing Radiation. (2017) (35)
- Age-Related Gene Expression Differences in Monocytes from Human Neonates, Young Adults, and Older Adults (2015) (34)
- Erratum: Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaos at centromeric heterochromatin (Genes and Development (1998) 12 (782-796)) (1998) (34)
- Genetic analysis of Ikaros target genes and tumor suppressor function in BCR-ABL1+ pre–B ALL (2017) (31)
- Assembly of silent chromatin during thymocyte development. (2005) (30)
- The primer extension assay. (2013) (29)
- A common ATP requirement for open complex formation and transcription at promoters containing initiator or TATA elements. (1993) (29)
- Regulation of gene expression dynamics during developmental transitions by the Ikaros transcription factor (2015) (28)
- The RNase protection assay. (2013) (28)
- Upstream of Ikaros. (2003) (27)
- Roles of TATA and initiator elements in determining the start site location and direction of RNA polymerase II transcription. (1992) (26)
- Transcriptional regulation in the immune system: a status report. (2014) (25)
- PCR-mediated site-directed mutagenesis. (2013) (25)
- Divergence of transcriptional landscape occurs early in B cell activation (2015) (24)
- Introduction to the Peptide Binding Problem of Computational Immunology: New Results (2014) (23)
- Towards a Mathematical Foundation of Immunology and Amino Acid Chains (2012) (23)
- Regulation of cooperative function of the Il12b enhancer and promoter by the interferon regulatory factors 3 and 5. (2013) (22)
- Dissection of acute stimulus-inducible nucleosome remodeling in mammalian cells (2019) (22)
- Micrococcal Nuclease-Southern Blot Assay: I. MNase and Restriction Digestions. (2007) (22)
- Inhibition of simian virus 40 DNA replication in vitro by poly(ADP-ribosyl)ated diadenosine tetraphosphate. (1987) (21)
- Isolation of a murine gene encoding a nucleic acid-binding protein with homology to hnRNP K. (1993) (20)
- Restriction of IL-22–Producing T Cell Responses and Differential Regulation of Regulatory T Cell Compartments by Zinc Finger Transcription Factor Ikaros (2014) (19)
- Confirming the functional importance of a protein-DNA interaction. (2012) (17)
- Ikaros Family Members from the Agnathan Myxine glutinosa and the Urochordate Oikopleura dioica: Emergence of an Essential Transcription Factor for Adaptive Immunity 1 (2003) (16)
- Comparison of reprogramming factor targets reveals both species-specific and conserved mechanisms in early iPSC reprogramming (2018) (14)
- Class-specific regulation of pro-inflammatory genes by MyD88 pathways and IκBζ. (2008) (14)
- Seq-ing LPS-induced enhancers. (2010) (12)
- A Th2 cytokine LCR. Adding a new piece to the regulatory puzzle. (2003) (12)
- Transcriptional Control of Inflammatory (2014) (12)
- Selectivity of the NF- k B Response (2010) (12)
- Designing an Enhancer Landscape (2012) (12)
- Hematopoiesis flies high with Ikaros (2006) (11)
- Class-specific regulation of pro-inflammatory genes by MyD88 pathways and IκBζ. (2015) (11)
- Title Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros Permalink (2013) (11)
- Transfection by electroporation of RAW 264.7 macrophages. (2010) (10)
- Selective Dimerization of a C 2 H 2 Zinc Finger (2003) (10)
- Prediction of residue-residue contacts from protein families using similarity kernels and least squares regularization (2013) (10)
- DEAE-dextran transfection of lymphocyte cell lines. (2010) (10)
- Inhibition of simian virus 40 DNA replication by specific modification of T-antigen with oxidized ATP. (1986) (9)
- DNase I footprinting. (2013) (9)
- IL-10 Promoter in Macrophages Lipopolysaccharide-Mediated Induction of A Prominent Role for Sp 1 During (2000) (9)
- Calcium phosphate transfection of 3T3 fibroblasts. (2010) (9)
- Immunity and Tolerance (2013) (9)
- Mechanisms of transcriptional regulation in lymphocyte progenitors: insight from an analysis of the terminal transferase promoter. (1999) (8)
- Electrophoretic mobility-shift assays. (2013) (8)
- MHC binding prediction with KernelRLSpan and its variations. (2014) (8)
- In vivo DNase I, MNase, and restriction enzyme footprinting via ligation-mediated polymerase chain reaction (LM-PCR). (2009) (7)
- Synthesis of 3-deoxy-3-fluoro-d-mannose and 4-deoxy-4- fluoro-d-mannose (1983) (7)
- Chloramphenicol acetyltransferase assay. (2010) (6)
- Identifying cis-acting DNA elements within a control region. (2012) (6)
- Experimental strategies for cloning or identifying genes encoding DNA-binding proteins. (2012) (5)
- Pursuing gene regulation 'logic' via RNA interference and chromatin immunoprecipitation (2006) (5)
- Suppressing fatty acid synthase by type I interferon and chemical inhibitors as a broad spectrum anti-viral strategy against SARS-CoV-2 (2022) (5)
- Methylation interference assay. (2007) (5)
- Toward an understanding of the gene-specific and global logic of inducible gene transcription. (2013) (5)
- What Can Immunologists Learn from Systems Approaches? (2018) (4)
- DNA sequence requirements for transcriptional initiator activity in mammalian cells (1994) (3)
- In vitro transcription using HeLa cell extracts and primer extension. (2009) (3)
- Species-Specific Relationships between DNA and Chromatin Properties of CpG Islands in Embryonic Stem Cells and Differentiated Cells (2021) (3)
- Purification of epitope-tagged transcription factor IID. (2010) (3)
- Mechanism of initiator-mediated transcription: evidence for a functional interaction between the TATA-binding protein and DNA in the absence of a specific recognition sequence (1993) (2)
- Purification of mediator from HeLa cell lines expressing a flag-tagged mediator subunit. (2010) (2)
- TPL-2 Inhibits IFN-β Expression via an ERK1/2-TCF-FOS Axis in TLR4-Stimulated Macrophages (2022) (2)
- Protein complex binding to promoter DNA: immobilized template assay. (2010) (2)
- G-less cassette in vitro transcription using HeLa cell nuclear extracts. (2010) (2)
- Inhibition of SV40 Replication In Vitro by Poly(ADP-Ribosyl)ated Diadenosine Tetraphosphate (1989) (2)
- Preparation of (32)P-end-labeled DNA fragments for performing DNA-binding experiments. (2013) (2)
- Magnesium-agarose electrophoretic mobility shift assay (EMSA) of transcription factor IID binding to DNA. (2010) (2)
- The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene (1994) (2)
- Rapid transcriptional reprogramming of the lipid biosynthesis genes in response to type I interferon (2016) (2)
- Global regulation of Toll-like receptor 4-induced inflammatory gene networks by physiologic stress signals in macrophages (INM7P.356) (2015) (1)
- In vivo dimethyl sulfate (DMS) footprinting via ligation-mediated polymerase chain reaction (LM-PCR). (2009) (1)
- Requirement for Mammalian Transcription Factor IID Transcriptional Activation by SP1 as Directed Through TATA or Initiator: Specific (2006) (1)
- Hydroxyl-radical footprinting. (2007) (1)
- Potassium permanganate probing of Pol II open complexes. (2010) (1)
- PL2-2 Selective regulation of pro-inflammatory genes by chromatin and NF-κB (2010) (1)
- A Future Outlook on Molecular Mechanisms of Immunity. (2020) (1)
- Oct4:Sox2 binding is essential for establishing but not maintaining active and silent states of dynamically regulated genes in pluripotent cells (2022) (1)
- Cold Spring Harbor Laboratory 2022: emerging insights and viewpoints in immunology. (2023) (0)
- Eukaryotic gene regulation: from chromatin to transcription to mRNA processing (2007) (0)
- Transcriptional activation bySpIasdirected through TATAor initiator: Specific requirement formammalian transcription factor HID (1990) (0)
- Erratum for Garcia et al., Pten Null Prostate Epithelium Promotes Localized Myeloid-Derived Suppressor Cell Expansion and Immune Suppression during Tumor Initiation and Progression (2014) (0)
- Abstract 3155: Interferon-gamma-induced melanoma plasticity and response to PD-1 blockade therapy (2020) (0)
- 118 : Modulation of Treg and Th17 fate decision by selective ikaros zinc fingers (2013) (0)
- Analysis of Ikaros tumor suppressor function in BCR-ABL1+ pre-B ALL reveals conserved target genes and biological pathways (2016) (0)
- Comparison of reprogramming factor targets reveals both species-specific and conserved mechanisms in early iPS cells (2017) (0)
- Divergence of transcriptional landscape occurs early in B cell activation (2015) (0)
- Kinetics of mRNA nuclear export regulate innate immune response gene expression (2022) (0)
- Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins (2020) (0)
- Faculty Opinions recommendation of Genome-wide lineage-specific transcriptional networks underscore Ikaros-dependent lymphoid priming in hematopoietic stem cells. (2009) (0)
- Regulation of B cell fate specification and VH gene rearrangements by Ikaros (2008) (0)
- LymphomagenesisCells Alters B Cell Properties and Promotes Transgenic Expression of Helios in B Lineage (2005) (0)
- IKZF2 (IKAROS family zinc finger 2) (2008) (0)
- Dr. Terri Grodzicker: leading Genes & Development through 35 years of rapidly advancing molecular biology research (2023) (0)
- 51: A STRINGENT MOLECULAR SYSTEMS APPROACH TO HUMAN INFLAMMATORY DISTRIBUTIVE SHOCK (2019) (0)
- Abstract 42: Control of Macrophage Cholesterol Efflux and Atherogenesis by the Noncoding RNA MeXis (2017) (0)
- Micrococcal Nuclease-Southern Blot Assay: II. Capillary Transfer and Hybridization. (2007) (0)
- Physiologic stress molecules activate an acute phase response and enhance macrophage antimicrobial activity to Mycobacterium leprae (INM3P.411) (2015) (0)
- The Ly6C(lo)-Down: Targeting Developmental Enhancers for Cell Subset Depletion. (2016) (0)
- Comparison of reprogramming factor targets reveals both species-specific and conserved mechanisms in early iPSC reprogramming (2018) (0)
- Limiting cholesterol biosynthesis acts as a danger signal that engages STING-dependent inflammation (INM2P.349) (2015) (0)
- Abstract 2325: IRF1 displays opposing tumor cell-intrinsic and -extrinsic roles in anti-tumor immunity (2023) (0)
- Role of Ikaros in hematopoiesis and tumor suppression: Selective functions of individual zinc fingers within the DNA-binding domain of Ikaros. (42.3) (2012) (0)
- Allogeneic hematopoietic stem cell transplantation: lessons learned by a molecular immunologist/transplant patient. (2022) (0)
- Hepatic GATA4 regulates cholesterol and triglyceride homeostasis in collaboration with LXRs (2022) (0)
- Abstracts of papers presented at the 2002 Meeting on Gene Expression & Signaling in the Immune System, April 24-April 28, 2002 (2002) (0)
- Phosphate ethylation interference assay. (2007) (0)
- SYNTHESIS OF 3-DEOXY-3-FLUORO-D-MANNOSE AND 4-DEOXY-4-FLUORO-D-MANNOSE (1983) (0)
- Selective requirement of Ikaros zinc fingers in Treg and Th17 fate decision. (P1137) (2013) (0)
This paper list is powered by the following services:
What Schools Are Affiliated With Stephen T. Smale?
Stephen T. Smale is affiliated with the following schools: