Stephen T. Smale

Stephen T. Smale's AcademicInfluence.com Rankings

Stephen T. Smale

Mathematics

#6589

World Rank

#9100

Historical Rank

Measure Theory

#1447

World Rank

#1812

Historical Rank

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Mathematics

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Stephen T. Smale's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. (1999) (1821)
The “initiator” as a transcription control element (1989) (1372)
The RNA polymerase II core promoter. (2003) (1178)
Association of Transcriptionally Silent Genes with Ikaros Complexes at Centromeric Heterochromatin (1997) (820)
DNA sequence requirements for transcriptional initiator activity in mammalian cells. (1994) (642)
Transcription initiation from TATA-less promoters within eukaryotic protein-coding genes. (1997) (576)
A Unifying Model for the Selective Regulation of Inducible Transcription by CpG Islands and Nucleosome Remodeling (2009) (574)
A role for Dicer in immune regulation (2006) (560)
T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer (2005) (538)
Transcript Dynamics of Proinflammatory Genes Revealed by Sequence Analysis of Subcellular RNA Fractions (2012) (421)
Selective and antagonistic functions of SWI/SNF and Mi-2beta nucleosome remodeling complexes during an inflammatory response. (2006) (416)
Transcriptional activation by Sp1 as directed through TATA or initiator: specific requirement for mammalian transcription factor IID. (1990) (388)
Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: evidence of functional synergy between C/EBP and Rel proteins (1997) (362)
Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages. (2000) (338)
Chromatin immunoprecipitation (ChIP). (2009) (307)
A Prominent Role for Sp1 During Lipopolysaccharide- Mediated Induction of the IL-10 Promoter in Macrophages1 (2000) (305)
Selective Transcription in Response to an Inflammatory Stimulus (2010) (289)
Transcriptional Regulation in Eukaryotes: Concepts, Strategies and Techniques (2000) (274)
Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros (2008) (266)
Targeting of Ikaros to pericentromeric heterochromatin by direct DNA binding. (2000) (265)
Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin. (1998) (263)
Core promoters: active contributors to combinatorial gene regulation. (2001) (257)
Direct recognition of initiator elements by a component of the transcription factor IID complex. (1994) (248)
Hierarchies of NF-κB target-gene regulation (2011) (242)
The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene. (1994) (237)
LyF-1, a transcriptional regulator that interacts with a novel class of promoters for lymphocyte-specific genes (1991) (205)
Generality of a functional initiator consensus sequence. (1996) (204)
Rapid and selective remodeling of a positioned nucleosome during the induction of IL-12 p40 transcription. (1999) (193)
Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits. (2007) (192)
Principles of dimer-specific gene regulation revealed by a comprehensive characterization of NF-κB family DNA binding (2011) (186)
Nucleosome remodeling at the IL-12 p40 promoter is a TLR-dependent, Rel-independent event (2001) (185)
T-antigen-DNA polymerase alpha complex implicated in simian virus 40 DNA replication (1986) (181)
Roles of TATA and initiator elements in determining the start site location and direction of RNA polymerase II transcription. (1992) (179)
Hematopoietic stem cells and lymphoid progenitors express different Ikaros isoforms, and Ikaros is localized to heterochromatin in immature lymphocytes. (1998) (179)
Transcriptional competence and the active marking of tissue-specific enhancers by defined transcription factors in embryonic and induced pluripotent stem cells. (2009) (175)
Chromatin structure and gene regulation in the immune system. (2002) (167)
Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor. (2003) (163)
Epigenetic characterization of hematopoietic stem cell differentiation using miniChIP and bisulfite sequencing analysis (2007) (162)
Down-regulation of TDT transcription in CD4(+)CD8(+) thymocytes by Ikaros proteins in direct competition with an Ets activator. (2001) (159)
Chromatin contributions to the regulation of innate immunity. (2014) (157)
Restraint of inflammatory signaling by interdependent strata of negative regulatory pathways (2012) (155)
Pioneer factors, genetic competence, and inductive signaling: programming liver and pancreas progenitors from the endoderm. (2008) (153)
Dimer‐specific regulatory mechanisms within the NF‐κB family of transcription factors (2012) (152)
Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA (2018) (147)
Cross-interference of RLR and TLR signaling pathways modulates antibacterial T cell responses (2012) (138)
Selectivity of the NF-{kappa}B response. (2010) (136)
Dynamic assembly of silent chromatin during thymocyte maturation (2004) (135)
Predominant Interaction of Both Ikaros and Helios with the NuRD Complex in Immature Thymocytes* (2007) (132)
A Stringent Systems Approach Uncovers Gene-Specific Mechanisms Regulating Inflammation (2016) (132)
A common mechanism for mitotic inactivation of C2H2 zinc finger DNA-binding domains. (2002) (131)
Transcription of herpes simplex virus tk sequences under the control of wild-type and mutant human RNA polymerase I promoters (1985) (125)
Selective dimerization of a C2H2 zinc finger subfamily. (2003) (125)
Interleukin-10 Inhibits Interleukin-12 p40 Gene Transcription by Targeting a Late Event in the Activation Pathway (2004) (122)
Pioneer factor interactions and unmethylated CpG dinucleotides mark silent tissue-specific enhancers in embryonic stem cells (2007) (122)
Core promoter specificities of the Sp1 and VP16 transcriptional activation domains (1995) (121)
Combinatorial regulation of transcription II: The immunoglobulin mu heavy chain gene. (1995) (119)
Two distinct promoter elements in the human rRNA gene identified by linker scanning mutagenesis (1986) (116)
A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation. (2005) (116)
Mechanism of initiator-mediated transcription: evidence for a functional interaction between the TATA-binding protein and DNA in the absence of a specific recognition sequence. (1993) (110)
IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure (2018) (109)
Pten Null Prostate Epithelium Promotes Localized Myeloid-Derived Suppressor Cell Expansion and Immune Suppression during Tumor Initiation and Progression (2014) (109)
Genome-wide identification of Ikaros targets elucidates its contribution to mouse B-cell lineage specification and pre-B-cell differentiation. (2013) (108)
C/EBPβ Regulation in Lipopolysaccharide-Stimulated Macrophages (2003) (107)
Mechanism of synergy between TATA and initiator: synergistic binding of TFIID following a putative TFIIA-induced isomerization. (1997) (99)
The initiator element: a paradigm for core promoter heterogeneity within metazoan protein-coding genes. (1998) (98)
Combinatorial regulation of transcription. I: General aspects of transcriptional control. (1995) (97)
NFIL3 Is a Regulator of IL-12 p40 in Macrophages and Mucosal Immunity (2011) (97)
Single cell analysis reveals immune cell–adipocyte crosstalk regulating the transcription of thermogenic adipocytes (2019) (92)
Transcriptional control of inflammatory responses. (2014) (91)
Transcriptional regulation in the innate immune system. (2012) (88)
let-7 miRNAs Can Act through Notch to Regulate Human Gliogenesis (2014) (88)
A Macrophage Response to Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage in Leprosy (2017) (83)
Splicing kinetics and transcript release from the chromatin compartment limit the rate of Lipid A-induced gene expression. (2013) (83)
Similar mechanisms for transcription initiation mediated through a TATA box or an initiator element. (1992) (82)
Similarity between a ubiquitous promoter element in an ancient eukaryote and mammalian initiator elements. (1994) (79)
Pioneer factors in embryonic stem cells and differentiation. (2010) (76)
Immune inhibitory ligand CD200 induction by TLRs and NLRs limits macrophage activation to protect the host from meningococcal septicemia. (2010) (74)
Class-specific Regulation of Pro-inflammatory Genes by MyD88 Pathways and IκBζ* (2008) (73)
Sp1 activation of a TATA-less promoter requires a species-specific interaction involving transcription factor IID. (1998) (72)
CIF, an essential cofactor for TFIID-dependent initiator function. (1996) (71)
Evaluation of the Long‐Term Reconstituting Subset of Hematopoietic Stem Cells with CD150 (2009) (70)
CIF150, a Human Cofactor for Transcription Factor IID-Dependent Initiator Function (1998) (69)
Regulation of human ribosomal RNA transcription. (1983) (68)
The establishment and maintenance of lymphocyte identity through gene silencing (2003) (67)
A Distal Enhancer in Il12b Is the Target of Transcriptional Repression by the STAT3 Pathway and Requires the Basic Leucine Zipper (B-ZIP) Protein NFIL3* (2011) (65)
Both LyF-1 and an Ets protein interact with a critical promoter element in the murine terminal transferase gene (1993) (65)
Beta-galactosidase assay. (2010) (62)
A potential role for Elf-1 in terminal transferase gene regulation (1996) (60)
Common Interaction Surfaces of the Toll-Like Receptor 4 Cytoplasmic Domain Stimulate Multiple Nuclear Targets (2003) (58)
HIV-1 core promoter lacks a simple initiator element but contains a bipartite activator at the transcription start site. (1993) (54)
Type I and Type II Interferon Coordinately Regulate Suppressive Dendritic Cell Fate and Function during Viral Persistence (2016) (51)
Toll-Like Receptors Induce Signal-Specific Reprogramming of the Macrophage Lipidome. (2020) (51)
Dignam and Roeder nuclear extract preparation. (2009) (51)
Luciferase assay. (2010) (50)
An Inducible Enhancer Required for Il12b Promoter Activity in an Insulated Chromatin Environment (2007) (50)
Self‐Renewal of the Long‐Term Reconstituting Subset of Hematopoietic Stem Cells Is Regulated by Ikaros (2009) (49)
C/EBPbeta regulation in lipopolysaccharide-stimulated macrophages. (2003) (47)
Opposing roles of Toll-like receptor and cytosolic DNA-STING signaling pathways for Staphylococcus aureus cutaneous host defense (2017) (46)
Nuclear run-on assay. (2009) (45)
Ikaros-family proteins: in search of molecular functions during lymphocyte development. (2005) (44)
Transcription of the lymphocyte-specific terminal deoxynucleotidyltransferase gene requires a specific core promoter structure. (1996) (43)
Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins (2020) (41)
Initiator Recognition in a Primitive Eukaryote: IBP39, an Initiator-Binding Protein from Trichomonas vaginalis (2001) (40)
Experimental strategies for the identification of DNA-binding proteins. (2012) (39)
Alternative pathway for induction of human immunodeficiency virus gene expression: involvement of the general transcription machinery (1991) (38)
Differential regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros (2013) (35)
Transgenic Expression of Helios in B Lineage Cells Alters B Cell Properties and Promotes Lymphomagenesis1 (2005) (35)
Defined Sensing Mechanisms and Signaling Pathways Contribute to the Global Inflammatory Gene Expression Output Elicited by Ionizing Radiation. (2017) (35)
Age-Related Gene Expression Differences in Monocytes from Human Neonates, Young Adults, and Older Adults (2015) (34)
Erratum: Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaos at centromeric heterochromatin (Genes and Development (1998) 12 (782-796)) (1998) (34)
Genetic analysis of Ikaros target genes and tumor suppressor function in BCR-ABL1+ pre–B ALL (2017) (31)
Assembly of silent chromatin during thymocyte development. (2005) (30)
The primer extension assay. (2013) (29)
A common ATP requirement for open complex formation and transcription at promoters containing initiator or TATA elements. (1993) (29)
Regulation of gene expression dynamics during developmental transitions by the Ikaros transcription factor (2015) (28)
The RNase protection assay. (2013) (28)
Upstream of Ikaros. (2003) (27)
Roles of TATA and initiator elements in determining the start site location and direction of RNA polymerase II transcription. (1992) (26)
Transcriptional regulation in the immune system: a status report. (2014) (25)
PCR-mediated site-directed mutagenesis. (2013) (25)
Divergence of transcriptional landscape occurs early in B cell activation (2015) (24)
Introduction to the Peptide Binding Problem of Computational Immunology: New Results (2014) (23)
Towards a Mathematical Foundation of Immunology and Amino Acid Chains (2012) (23)
Regulation of cooperative function of the Il12b enhancer and promoter by the interferon regulatory factors 3 and 5. (2013) (22)
Dissection of acute stimulus-inducible nucleosome remodeling in mammalian cells (2019) (22)
Micrococcal Nuclease-Southern Blot Assay: I. MNase and Restriction Digestions. (2007) (22)
Inhibition of simian virus 40 DNA replication in vitro by poly(ADP-ribosyl)ated diadenosine tetraphosphate. (1987) (21)
Isolation of a murine gene encoding a nucleic acid-binding protein with homology to hnRNP K. (1993) (20)
Restriction of IL-22–Producing T Cell Responses and Differential Regulation of Regulatory T Cell Compartments by Zinc Finger Transcription Factor Ikaros (2014) (19)
Confirming the functional importance of a protein-DNA interaction. (2012) (17)
Ikaros Family Members from the Agnathan Myxine glutinosa and the Urochordate Oikopleura dioica: Emergence of an Essential Transcription Factor for Adaptive Immunity 1 (2003) (16)
Comparison of reprogramming factor targets reveals both species-specific and conserved mechanisms in early iPSC reprogramming (2018) (14)
Class-specific regulation of pro-inflammatory genes by MyD88 pathways and IκBζ. (2008) (14)
Seq-ing LPS-induced enhancers. (2010) (12)
A Th2 cytokine LCR. Adding a new piece to the regulatory puzzle. (2003) (12)
Transcriptional Control of Inflammatory (2014) (12)
Selectivity of the NF- k B Response (2010) (12)
Designing an Enhancer Landscape (2012) (12)
Hematopoiesis flies high with Ikaros (2006) (11)
Class-specific regulation of pro-inflammatory genes by MyD88 pathways and IκBζ. (2015) (11)
Title Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros Permalink (2013) (11)
Transfection by electroporation of RAW 264.7 macrophages. (2010) (10)
Selective Dimerization of a C 2 H 2 Zinc Finger (2003) (10)
Prediction of residue-residue contacts from protein families using similarity kernels and least squares regularization (2013) (10)
DEAE-dextran transfection of lymphocyte cell lines. (2010) (10)
Inhibition of simian virus 40 DNA replication by specific modification of T-antigen with oxidized ATP. (1986) (9)
DNase I footprinting. (2013) (9)
IL-10 Promoter in Macrophages Lipopolysaccharide-Mediated Induction of A Prominent Role for Sp 1 During (2000) (9)
Calcium phosphate transfection of 3T3 fibroblasts. (2010) (9)
Immunity and Tolerance (2013) (9)
Mechanisms of transcriptional regulation in lymphocyte progenitors: insight from an analysis of the terminal transferase promoter. (1999) (8)
Electrophoretic mobility-shift assays. (2013) (8)
MHC binding prediction with KernelRLSpan and its variations. (2014) (8)
In vivo DNase I, MNase, and restriction enzyme footprinting via ligation-mediated polymerase chain reaction (LM-PCR). (2009) (7)
Synthesis of 3-deoxy-3-fluoro-d-mannose and 4-deoxy-4- fluoro-d-mannose (1983) (7)
Chloramphenicol acetyltransferase assay. (2010) (6)
Identifying cis-acting DNA elements within a control region. (2012) (6)
Experimental strategies for cloning or identifying genes encoding DNA-binding proteins. (2012) (5)
Pursuing gene regulation 'logic' via RNA interference and chromatin immunoprecipitation (2006) (5)
Suppressing fatty acid synthase by type I interferon and chemical inhibitors as a broad spectrum anti-viral strategy against SARS-CoV-2 (2022) (5)
Methylation interference assay. (2007) (5)
Toward an understanding of the gene-specific and global logic of inducible gene transcription. (2013) (5)
What Can Immunologists Learn from Systems Approaches? (2018) (4)
DNA sequence requirements for transcriptional initiator activity in mammalian cells (1994) (3)
In vitro transcription using HeLa cell extracts and primer extension. (2009) (3)
Species-Specific Relationships between DNA and Chromatin Properties of CpG Islands in Embryonic Stem Cells and Differentiated Cells (2021) (3)
Purification of epitope-tagged transcription factor IID. (2010) (3)
Mechanism of initiator-mediated transcription: evidence for a functional interaction between the TATA-binding protein and DNA in the absence of a specific recognition sequence (1993) (2)
Purification of mediator from HeLa cell lines expressing a flag-tagged mediator subunit. (2010) (2)
TPL-2 Inhibits IFN-β Expression via an ERK1/2-TCF-FOS Axis in TLR4-Stimulated Macrophages (2022) (2)
Protein complex binding to promoter DNA: immobilized template assay. (2010) (2)
G-less cassette in vitro transcription using HeLa cell nuclear extracts. (2010) (2)
Inhibition of SV40 Replication In Vitro by Poly(ADP-Ribosyl)ated Diadenosine Tetraphosphate (1989) (2)
Preparation of (32)P-end-labeled DNA fragments for performing DNA-binding experiments. (2013) (2)
Magnesium-agarose electrophoretic mobility shift assay (EMSA) of transcription factor IID binding to DNA. (2010) (2)
The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene (1994) (2)
Rapid transcriptional reprogramming of the lipid biosynthesis genes in response to type I interferon (2016) (2)
Global regulation of Toll-like receptor 4-induced inflammatory gene networks by physiologic stress signals in macrophages (INM7P.356) (2015) (1)
In vivo dimethyl sulfate (DMS) footprinting via ligation-mediated polymerase chain reaction (LM-PCR). (2009) (1)
Requirement for Mammalian Transcription Factor IID Transcriptional Activation by SP1 as Directed Through TATA or Initiator: Specific (2006) (1)
Hydroxyl-radical footprinting. (2007) (1)
Potassium permanganate probing of Pol II open complexes. (2010) (1)
PL2-2 Selective regulation of pro-inflammatory genes by chromatin and NF-κB (2010) (1)
A Future Outlook on Molecular Mechanisms of Immunity. (2020) (1)
Oct4:Sox2 binding is essential for establishing but not maintaining active and silent states of dynamically regulated genes in pluripotent cells (2022) (1)
Cold Spring Harbor Laboratory 2022: emerging insights and viewpoints in immunology. (2023) (0)
Eukaryotic gene regulation: from chromatin to transcription to mRNA processing (2007) (0)
Transcriptional activation bySpIasdirected through TATAor initiator: Specific requirement formammalian transcription factor HID (1990) (0)
Erratum for Garcia et al., Pten Null Prostate Epithelium Promotes Localized Myeloid-Derived Suppressor Cell Expansion and Immune Suppression during Tumor Initiation and Progression (2014) (0)
Abstract 3155: Interferon-gamma-induced melanoma plasticity and response to PD-1 blockade therapy (2020) (0)
118 : Modulation of Treg and Th17 fate decision by selective ikaros zinc fingers (2013) (0)
Analysis of Ikaros tumor suppressor function in BCR-ABL1+ pre-B ALL reveals conserved target genes and biological pathways (2016) (0)
Comparison of reprogramming factor targets reveals both species-specific and conserved mechanisms in early iPS cells (2017) (0)
Divergence of transcriptional landscape occurs early in B cell activation (2015) (0)
Kinetics of mRNA nuclear export regulate innate immune response gene expression (2022) (0)
Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins (2020) (0)
Faculty Opinions recommendation of Genome-wide lineage-specific transcriptional networks underscore Ikaros-dependent lymphoid priming in hematopoietic stem cells. (2009) (0)
Regulation of B cell fate specification and VH gene rearrangements by Ikaros (2008) (0)
LymphomagenesisCells Alters B Cell Properties and Promotes Transgenic Expression of Helios in B Lineage (2005) (0)
IKZF2 (IKAROS family zinc finger 2) (2008) (0)
Dr. Terri Grodzicker: leading Genes & Development through 35 years of rapidly advancing molecular biology research (2023) (0)
51: A STRINGENT MOLECULAR SYSTEMS APPROACH TO HUMAN INFLAMMATORY DISTRIBUTIVE SHOCK (2019) (0)
Abstract 42: Control of Macrophage Cholesterol Efflux and Atherogenesis by the Noncoding RNA MeXis (2017) (0)
Micrococcal Nuclease-Southern Blot Assay: II. Capillary Transfer and Hybridization. (2007) (0)
Physiologic stress molecules activate an acute phase response and enhance macrophage antimicrobial activity to Mycobacterium leprae (INM3P.411) (2015) (0)
The Ly6C(lo)-Down: Targeting Developmental Enhancers for Cell Subset Depletion. (2016) (0)
Comparison of reprogramming factor targets reveals both species-specific and conserved mechanisms in early iPSC reprogramming (2018) (0)
Limiting cholesterol biosynthesis acts as a danger signal that engages STING-dependent inflammation (INM2P.349) (2015) (0)
Abstract 2325: IRF1 displays opposing tumor cell-intrinsic and -extrinsic roles in anti-tumor immunity (2023) (0)
Role of Ikaros in hematopoiesis and tumor suppression: Selective functions of individual zinc fingers within the DNA-binding domain of Ikaros. (42.3) (2012) (0)
Allogeneic hematopoietic stem cell transplantation: lessons learned by a molecular immunologist/transplant patient. (2022) (0)
Hepatic GATA4 regulates cholesterol and triglyceride homeostasis in collaboration with LXRs (2022) (0)
Abstracts of papers presented at the 2002 Meeting on Gene Expression & Signaling in the Immune System, April 24-April 28, 2002 (2002) (0)
Phosphate ethylation interference assay. (2007) (0)
SYNTHESIS OF 3-DEOXY-3-FLUORO-D-MANNOSE AND 4-DEOXY-4-FLUORO-D-MANNOSE (1983) (0)
Selective requirement of Ikaros zinc fingers in Treg and Th17 fate decision. (P1137) (2013) (0)

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What Schools Are Affiliated With Stephen T. Smale?

Stephen T. Smale is affiliated with the following schools:

University of California, San Diego
University of California, Los Angeles
Cornell University

Stephen T. Smale's Academic­Influence.com Rankings

Why Is Stephen T. Smale Influential?

Stephen T. Smale's Published Works

Published Works

What Schools Are Affiliated With Stephen T. Smale?

Stephen T. Smale's AcademicInfluence.com Rankings