Steve Horvath
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German-American aging researcher and geneticist
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Why Is Steve Horvath Influential?
(Suggest an Edit or Addition)According to Wikipedia, Steve Horvath is a German–American aging researcher, geneticist, and biostatistician. He is a professor at the University of California, Los Angeles known for developing the Horvath aging clock, which is a highly accurate molecular biomarker of aging, and for developing weighted correlation network analysis. His work on the genomic biomarkers of aging, the aging process, and many age related diseases/conditions has earned him several research awards. Horvath is a principal investigator at the anti-aging startup Altos Labs and co-founder of nonprofit Clock Foundation.
Steve Horvath's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- WGCNA: an R package for weighted correlation network analysis (2008) (13093)
- A General Framework for Weighted Gene Co-Expression Network Analysis (2005) (4337)
- DNA methylation age of human tissues and cell types (2013) (3942)
- An anatomically comprehensive atlas of the adult human brain transcriptome (2012) (2002)
- Defining clusters from a hierarchical cluster tree: the Dynamic Tree Cut package for R (2008) (1626)
- Transcriptomic Analysis of Autistic Brain Reveals Convergent Molecular Pathology (2011) (1601)
- Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors. (2005) (1455)
- DNA methylation-based biomarkers and the epigenetic clock theory of ageing (2018) (1235)
- An epigenetic biomarker of aging for lifespan and healthspan (2018) (1069)
- Global histone modification patterns predict risk of prostate cancer recurrence (2005) (1064)
- Implementing a unified approach to family‐based tests of association (2000) (915)
- Variations in DNA elucidate molecular networks that cause disease (2008) (901)
- DNA methylation age of blood predicts all-cause mortality in later life (2015) (871)
- Integrative Functional Genomic Analyses Implicate Specific Molecular Pathways and Circuits in Autism (2013) (862)
- Fast R Functions for Robust Correlations and Hierarchical Clustering. (2012) (809)
- Genetic programs in human and mouse early embryos revealed by single-cell RNA sequencing (2013) (804)
- The family based association test method: strategies for studying general genotype–phenotype associations (2001) (777)
- Is My Network Module Preserved and Reproducible? (2011) (749)
- Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap (2016) (742)
- Epigenetic Predictor of Age (2011) (739)
- Gene Expression Profiling of Gliomas Strongly Predicts Survival (2004) (735)
- DNA methylation GrimAge strongly predicts lifespan and healthspan (2019) (727)
- Geometric Interpretation of Gene Coexpression Network Analysis (2008) (720)
- Functional organization of the transcriptome in human brain (2008) (718)
- Eigengene networks for studying the relationships between co-expression modules (2007) (709)
- DNA methylation-based measures of biological age: meta-analysis predicting time to death (2016) (699)
- Carbonic anhydrase IX is an independent predictor of survival in advanced renal clear cell carcinoma: implications for prognosis and therapy. (2003) (665)
- Role of the Murine Reprogramming Factors in the Induction of Pluripotency (2009) (660)
- Conservation and evolution of gene coexpression networks in human and chimpanzee brains (2006) (570)
- Antitumor Activity of Rapamycin in a Phase I Trial for Patients with Recurrent PTEN-Deficient Glioblastoma (2008) (568)
- Obesity accelerates epigenetic aging of human liver (2014) (557)
- Aging effects on DNA methylation modules in human brain and blood tissue (2012) (539)
- Gene network interconnectedness and the generalized topological overlap measure (2007) (537)
- Global analysis of gene activity during Arabidopsis seed development and identification of seed-specific transcription factors (2010) (523)
- Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism (2016) (490)
- Global levels of histone modifications predict prognosis in different cancers. (2009) (489)
- Integrating Genetic and Network Analysis to Characterize Genes Related to Mouse Weight (2006) (462)
- An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease (2016) (456)
- Analysis of the phosphatidylinositol 3'-kinase signaling pathway in glioblastoma patients in vivo. (2003) (449)
- Epigenetic clock analysis of diet, exercise, education, and lifestyle factors (2017) (437)
- Unsupervised Learning With Random Forest Predictors (2006) (430)
- Divergence of human and mouse brain transcriptome highlights Alzheimer disease pathways (2010) (422)
- Understanding network concepts in modules (2007) (419)
- The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936 (2015) (416)
- Family‐based tests for associating haplotypes with general phenotype data: Application to asthma genetics (2004) (410)
- HIV-1 Infection Accelerates Age According to the Epigenetic Clock (2015) (409)
- DNA methylation aging clocks: challenges and recommendations (2019) (393)
- Accelerated epigenetic aging in Down syndrome (2015) (381)
- Comparison of co-expression measures: mutual information, correlation, and model based indices (2012) (357)
- Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target (2006) (357)
- Gene connectivity, function, and sequence conservation: predictions from modular yeast co-expression networks (2006) (342)
- Weighted gene coexpression network analysis strategies applied to mouse weight (2007) (333)
- Sexually dimorphic gene expression in mouse brain precedes gonadal differentiation. (2003) (329)
- Epigenetic age of the pre-frontal cortex is associated with neuritic plaques, amyloid load, and Alzheimer’s disease related cognitive functioning (2015) (325)
- Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance (2010) (319)
- Identification of inflammatory gene modules based on variations of human endothelial cell responses to oxidized lipids (2006) (316)
- Gene expression profiling identifies molecular subtypes of gliomas (2003) (312)
- Increased epigenetic age and granulocyte counts in the blood of Parkinson's disease patients (2015) (311)
- EGFR Signaling Through an Akt-SREBP-1–Dependent, Rapamycin-Resistant Pathway Sensitizes Glioblastomas to Antilipogenic Therapy (2009) (305)
- Menopause accelerates biological aging (2016) (295)
- Strategies for aggregating gene expression data: The collapseRows R function (2011) (294)
- Differential sensitivity of glioma- versus lung cancer-specific EGFR mutations to EGFR kinase inhibitors. (2012) (290)
- Integrated genomics and proteomics to define huntingtin CAG length-dependent networks in HD Mice (2016) (288)
- Kidney Transplant Rejection and Tissue Injury by Gene Profiling of Biopsies and Peripheral Blood Lymphocytes (2004) (283)
- Identification of molecular subtypes of glioblastoma by gene expression profiling (2003) (280)
- Reprogramming to recover youthful epigenetic information and restore vision (2020) (273)
- Mutations in CLCN2 encoding a voltage-gated chloride channel are associated with idiopathic generalized epilepsies (2003) (271)
- Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies (2018) (268)
- A Systems-Level Analysis of the Peripheral Nerve Intrinsic Axonal Growth Program (2016) (267)
- Network Organization of the Huntingtin Proteomic Interactome in Mammalian Brain (2012) (266)
- Reversal of epigenetic aging and immunosenescent trends in humans (2019) (260)
- Decreased epigenetic age of PBMCs from Italian semi-supercentenarians and their offspring (2015) (244)
- When Is Hub Gene Selection Better than Standard Meta-Analysis? (2013) (244)
- Neurosphere Formation Is an Independent Predictor of Clinical Outcome in Malignant Glioma (2009) (234)
- DNA methylation age of blood predicts future onset of lung cancer in the women's health initiative (2015) (234)
- Integrative analysis of the microbiome and metabolome of the human intestinal mucosal surface reveals exquisite inter-relationships (2013) (231)
- Using Protein Expressions to Predict Survival in Clear Cell Renal Carcinoma (2004) (223)
- A discordant-sibship test for disequilibrium and linkage: no need for parental data. (1998) (222)
- DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases (2016) (215)
- Elucidating the role of gonadal hormones in sexually dimorphic gene coexpression networks. (2009) (213)
- Genes and pathways underlying regional and cell type changes in Alzheimer's disease (2013) (208)
- Signed weighted gene co-expression network analysis of transcriptional regulation in murine embryonic stem cells (2009) (208)
- Single-Cell Transcriptome Analyses Reveal Signals to Activate Dormant Neural Stem Cells (2015) (206)
- Gene expression analysis of glioblastomas identifies the major molecular basis for the prognostic benefit of younger age (2008) (206)
- Prostate Stem Cell Antigen Is Overexpressed in Prostate Cancer Metastases (2005) (203)
- Cellular histone modification patterns predict prognosis and treatment response in resectable pancreatic adenocarcinoma: results from RTOG 9704. (2010) (202)
- Genetic analysis of DNA methylation and gene expression levels in whole blood of healthy human subjects (2012) (194)
- Tumor classification by tissue microarray profiling: random forest clustering applied to renal cell carcinoma (2005) (194)
- Prognostic value of carbonic anhydrase IX and KI67 as predictors of survival for renal clear cell carcinoma. (2004) (193)
- Network neighborhood analysis with the multi-node topological overlap measure (2007) (188)
- Using tumor markers to predict the survival of patients with metastatic renal cell carcinoma. (2005) (178)
- Resting-State Quantitative Electroencephalography Reveals Increased Neurophysiologic Connectivity in Depression (2012) (177)
- Prenatal and early life influences on epigenetic age in children: a study of mother–offspring pairs from two cohort studies (2015) (177)
- Insulin growth factor-binding protein 2 is a candidate biomarker for PTEN status and PI3K/Akt pathway activation in glioblastoma and prostate cancer (2007) (176)
- Longitudinal changes of telomere length and epigenetic age related to traumatic stress and post-traumatic stress disorder (2015) (173)
- Integrated Weighted Gene Co-expression Network Analysis with an Application to Chronic Fatigue Syndrome (2008) (172)
- A Systems Genetics Approach Implicates USF1, FADS3, and Other Causal Candidate Genes for Familial Combined Hyperlipidemia (2009) (166)
- Huntington's disease accelerates epigenetic aging of human brain and disrupts DNA methylation levels (2016) (164)
- MCT1 Modulates Cancer Cell Pyruvate Export and Growth of Tumors that Co-express MCT1 and MCT4. (2016) (164)
- An epigenetic clock for gestational age at birth based on blood methylation data (2016) (164)
- Clinicopathologic and molecular correlations of necrosis in the primary tumor of patients with renal cell carcinoma (2005) (163)
- Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells (2008) (160)
- The cerebellum ages slowly according to the epigenetic clock (2015) (158)
- A Modular Organization of the Human Intestinal Mucosal Microbiota and Its Association with Inflammatory Bowel Disease (2013) (156)
- Expression of transcription factor Yin Yang 1 in prostate cancer. (2005) (156)
- Weighted gene co-expression network analysis of the peripheral blood from Amyotrophic Lateral Sclerosis patients (2009) (155)
- Higher levels of GATA3 predict better survival in women with breast cancer. (2010) (153)
- High concentrations of long interspersed nuclear element sequence distinguish monoallelically expressed genes (2003) (150)
- Using genetic markers to orient the edges in quantitative trait networks: The NEO software (2008) (150)
- Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells (2020) (136)
- Maintenance of age in human neurons generated by microRNA-based neuronal conversion of fibroblasts (2016) (133)
- DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation. (2017) (132)
- A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: A cohort study (2018) (132)
- GWAS of epigenetic aging rates in blood reveals a critical role for TERT (2017) (132)
- A Gene Co-Expression Network in Whole Blood of Schizophrenia Patients Is Independent of Antipsychotic-Use and Enriched for Brain-Expressed Genes (2012) (131)
- Prostate stem cell antigen expression is associated with gleason score, seminal vesicle invasion and capsular invasion in prostate cancer. (2004) (130)
- Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism (2014) (129)
- A multi-tissue full lifespan epigenetic clock for mice (2018) (128)
- Epithelial Cell Adhesion Molecule (KSA) Expression (2004) (127)
- Biomarkers to Predict Antidepressant Response (2010) (127)
- DNA methylome analysis identifies accelerated epigenetic ageing associated with postmenopausal breast cancer susceptibility. (2017) (125)
- DNA methylation-based estimator of telomere length (2019) (123)
- Long Term Maturation of Human Cortical Organoids Matches Key Early Postnatal Transitions (2021) (120)
- Epigenetic clock analyses of cellular senescence and ageing (2016) (120)
- The organization of the transcriptional network in specific neuronal classes (2009) (119)
- Air-pollutant chemicals and oxidized lipids exhibit genome-wide synergistic effects on endothelial cells (2007) (119)
- Random generalized linear model: a highly accurate and interpretable ensemble predictor (2013) (116)
- Network methods for describing sample relationships in genomic datasets: application to Huntington’s disease (2012) (116)
- GrimAge outperforms other epigenetic clocks in the prediction of age-related clinical phenotypes and all-cause mortality. (2020) (116)
- Accelerated epigenetic aging in Werner syndrome (2017) (116)
- Molecular Microcircuitry Underlies Functional Specification in a Basal Ganglia Circuit Dedicated to Vocal Learning (2012) (111)
- Relationship between Survival and Edema in Malignant Gliomas: Role of Vascular Endothelial Growth Factor and Neuronal Pentraxin 2 (2007) (107)
- IL-32 is a molecular marker of a host defense network in human tuberculosis (2014) (107)
- Is human blood a good surrogate for brain tissue in transcriptional studies? (2010) (105)
- Erratum to: DNA methylation age of human tissues and cell types (2015) (105)
- Development of a Real-time RT-PCR Assay for Detecting EGFRvIII in Glioblastoma Samples (2008) (104)
- Breast Cancer Molecular Signatures as Determined by SAGE: Correlation with Lymph Node Status (2007) (103)
- Acceleration of Age-Associated Methylation Patterns in HIV-1-Infected Adults (2015) (101)
- Correlation of Ki-67 and gelsolin expression to clinical outcome in renal clear cell carcinoma. (2003) (101)
- Gene Coexpression Network Topology of Cardiac Development, Hypertrophy, and Failure (2011) (100)
- Expression of colony-stimulating factor 1 receptor during prostate development and prostate cancer progression (2002) (99)
- Blood Leukocyte DNA Methylation Predicts Risk of Future Myocardial Infarction and Coronary Heart Disease. (2019) (99)
- Molecular Classifiers for Acute Kidney Transplant Rejection in Peripheral Blood by Whole Genome Gene Expression Profiling (2014) (98)
- p53 is an independent predictor of tumor recurrence and progression after nephrectomy in patients with localized renal cell carcinoma. (2005) (97)
- An epigenetic aging clock for dogs and wolves (2017) (97)
- Parkinson’s disease is associated with DNA methylation levels in human blood and saliva (2017) (97)
- Accelerated epigenetic aging in brain is associated with pre-mortem HIV-associated neurocognitive disorders (2016) (93)
- Transcriptome analyses reveal molecular mechanisms underlying functional recovery after spinal cord injury (2015) (91)
- The PedBE clock accurately estimates DNA methylation age in pediatric buccal cells (2019) (90)
- Universal DNA Methylation Age Across Mammalian Tissues (2021) (89)
- Epigenetic Aging and Immune Senescence in Women With Insomnia Symptoms: Findings From the Women’s Health Initiative Study (2017) (89)
- Retraction: Mutations in CLCN2 encoding a voltage-gated chloride channel are associated with idiopathic generalized epilepsies (2003) (88)
- Tissue microarray analysis of cytoskeletal actin‐associated biomarkers gelsolin and E‐cadherin in urothelial carcinoma (2002) (87)
- Neuropathological and transcriptomic characteristics of the aged brain (2017) (87)
- Expression of X-Linked Inhibitor of Apoptosis Protein Is a Strong Predictor of Human Prostate Cancer Recurrence (2007) (86)
- Analysis of the Na,K‐ATPase α‐ and β‐subunit expression profiles of bladder cancer using tissue microarrays (2003) (86)
- "Good enough solutions" and the genetics of complex diseases. (2012) (86)
- Low CD38 Identifies Progenitor-like Inflammation-Associated Luminal Cells that Can Initiate Human Prostate Cancer and Predict Poor Outcome (2016) (82)
- A mammalian methylation array for profiling methylation levels at conserved sequences (2021) (82)
- Loss of CD10 (neutral endopeptidase) is a frequent and early event in human prostate cancer (2003) (81)
- Systematic evaluation of DNA methylation age estimation with common preprocessing methods and the Infinium MethylationEPIC BeadChip array (2018) (81)
- The epigenetic clock and physical development during childhood and adolescence: longitudinal analysis from a UK birth cohort (2017) (80)
- Biomarkers for Early and Late Stage Chronic Allograft Nephropathy by Proteogenomic Profiling of Peripheral Blood (2009) (79)
- Alteration in basal and depolarization induced transcriptional network in iPSC derived neurons from Timothy syndrome (2014) (79)
- Systems biology analysis of Sjögren's syndrome and mucosa-associated lymphoid tissue lymphoma in parotid glands. (2009) (76)
- Progesterone and estrogen receptor expression and activity in human non-small cell lung cancer (2011) (76)
- Detecting network modules in fMRI time series: A weighted network analysis approach (2010) (73)
- Gene networks associated with conditional fear in mice identified using a systems genetics approach (2011) (73)
- Faster ticking rate of the epigenetic clock is associated with faster pubertal development in girls (2018) (72)
- Flap endonuclease 1 is overexpressed in prostate cancer and is associated with a high Gleason score (2006) (71)
- Genetic architecture of epigenetic and neuronal ageing rates in human brain regions (2017) (68)
- Statistical Methods for Analyzing Tissue Microarray Data (2004) (68)
- Differential expression of anterior gradient gene AGR2 in prostate cancer (2010) (67)
- Epigenetic measures of ageing predict the prevalence and incidence of leading causes of death and disease burden (2020) (67)
- An Epigenetic Signature in Peripheral Blood Associated with the Haplotype on 17q21.31, a Risk Factor for Neurodegenerative Tauopathy (2014) (66)
- Expression levels of estrogen receptor beta in conjunction with aromatase predict survival in non-small cell lung cancer. (2011) (66)
- DNA methylation age is accelerated in alcohol dependence (2018) (65)
- An epigenetic predictor of death captures multi-modal measures of brain health (2019) (64)
- Antibody-Based Profiling of the Phosphoinositide 3-Kinase Pathway in Clinical Prostate Cancer (2004) (63)
- Gene expression signatures affected by alcohol-induced DNA methylomic deregulation in human embryonic stem cells. (2014) (63)
- A meta-analysis of genome-wide association studies of epigenetic age acceleration (2019) (63)
- The transmission/disequilibrium test and parental-genotype reconstruction for X-chromosomal markers. (2000) (62)
- Tracking the Epigenetic Clock Across the Human Life Course: A Meta-analysis of Longitudinal Cohort Data (2018) (62)
- Extreme skewing of X chromosome inactivation in mothers of homosexual men (2006) (62)
- Systems analysis of human brain gene expression: mechanisms for HIV-associated neurocognitive impairment and common pathways with Alzheimer’s disease (2013) (61)
- An epigenome-wide association study meta-analysis of educational attainment (2017) (60)
- Perinatally acquired HIV infection accelerates epigenetic aging in South African adolescents (2018) (60)
- Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients (2021) (60)
- Metabolic and inflammatory biomarkers are associated with epigenetic aging acceleration estimates in the GOLDN study (2018) (60)
- Trefoil factor 3 is overexpressed in human prostate cancer (2004) (58)
- Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum (2016) (57)
- An Integrative Genetics Approach to Identify Candidate Genes Regulating BMD: Combining Linkage, Gene Expression, and Association (2009) (57)
- Glycerol kinase deficiency alters expression of genes involved in lipid metabolism, carbohydrate metabolism, and insulin signaling (2007) (57)
- Presence of a putative tumor-initiating progenitor cell population predicts poor prognosis in smokers with non-small cell lung cancer. (2010) (56)
- Association of genetic variation in the tachykinin receptor 3 locus with hot flashes and night sweats in the Women's Health Initiative Study (2017) (55)
- Repetitive sequence environment distinguishes housekeeping genes. (2007) (54)
- Breast cancer treatment and its effects on aging. (2019) (53)
- Association analysis between the human interleukin 1β (−511) gene polymorphism and susceptibility to febrile convulsions (2002) (53)
- Reg IV: A Promising Marker of Hormone Refractory Metastatic Prostate Cancer (2005) (53)
- Mapping of Gene Expression Reveals CYP27A1 as a Susceptibility Gene for Sporadic ALS (2012) (52)
- DNA methylation predicts age and provides insight into exceptional longevity of bats (2021) (52)
- DNA Methylation Profiling of Human Prefrontal Cortex Neurons in Heroin Users Shows Significant Difference between Genomic Contexts of Hyper- and Hypomethylation and a Younger Epigenetic Age (2017) (52)
- Analysis of the Na,K-ATPase alpha- and beta-subunit expression profiles of bladder cancer using tissue microarrays. (2003) (52)
- Systems analysis of primary Sjögren's syndrome pathogenesis in salivary glands identifies shared pathways in human and a mouse model (2012) (51)
- Epigenetic ageing is distinct from senescence-mediated ageing and is not prevented by telomerase expression (2018) (51)
- Analysis of DNA methylation associates the cystine–glutamate antiporter SLC7A11 with risk of Parkinson’s disease (2020) (50)
- Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging (2021) (48)
- Identification of schizophrenia-associated loci by combining DNA methylation and gene expression data from whole blood (2014) (47)
- DNA methylation age is elevated in breast tissue of healthy women (2017) (46)
- Distinct gene expression profiles in adult mouse heart following targeted MAP kinase activation. (2006) (45)
- Expression of phosphorylated raf kinase inhibitor protein (pRKIP) is a predictor of lung cancer survival (2011) (45)
- An epigenetic clock for human skeletal muscle (2019) (44)
- Current perspectives on the cellular and molecular features of epigenetic ageing (2020) (44)
- Organophosphate pesticide exposure and differential genome-wide DNA methylation. (2018) (43)
- CLCN2 variants in idiopathic generalized epilepsy (2009) (43)
- Protein expression based multimarker analysis of breast cancer samples (2011) (43)
- Methylome-wide association study provides evidence of particulate matter air pollution-associated DNA methylation (2019) (43)
- Epigenetic aging is accelerated in alcohol use disorder and regulated by genetic variation in APOL2 (2019) (42)
- Placental epigenetic clocks: estimating gestational age using placental DNA methylation levels (2019) (41)
- Exosomes and Homeostatic Synaptic Plasticity Are Linked to Each other and to Huntington's, Parkinson's, and Other Neurodegenerative Diseases by Database-Enabled Analyses of Comprehensively Curated Datasets (2017) (41)
- High expression of AGR2 in lung cancer is predictive of poor survival (2015) (41)
- Network module detection: Affinity search technique with the multi-node topological overlap measure (2009) (40)
- Na,K-adenosine triphosphatase alpha1-subunit predicts survival of renal clear cell carcinoma. (2008) (40)
- Incorporation of a nucleoside analog maps genome repair sites in postmitotic human neurons (2021) (40)
- Weighted gene co-expression network analysis identifies biomarkers in glycerol kinase deficient mice. (2009) (39)
- Clonal hematopoiesis associated with epigenetic aging and clinical outcomes (2021) (38)
- In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice (2022) (38)
- The role of epigenetic aging in education and racial/ethnic mortality disparities among older U.S. Women (2019) (38)
- Synchrony and asynchrony between an epigenetic clock and developmental timing (2019) (37)
- Prodynorphin gene promoter polymorphism and temporal lobe epilepsy (2003) (37)
- Cell and tissue type independent age-associated DNA methylation changes are not rare but common (2018) (37)
- Epigenetic age analysis of children who seem to evade aging (2015) (37)
- Leukocyte telomere length, T cell composition and DNA methylation age (2017) (36)
- Specific premature epigenetic aging of cartilage in osteoarthritis (2016) (36)
- Prostate cancer cell phenotypes based on AGR2 and CD10 expression (2012) (36)
- Seasonal changes in gene expression represent cell-type composition in whole blood. (2014) (36)
- DNA Methylation Analysis Validates Organoids as a Viable Model for Studying Human Intestinal Aging (2019) (35)
- MicroRNA signatures of endogenous Huntingtin CAG repeat expansion in mice (2018) (35)
- Epigenetic age acceleration and metabolic syndrome in the coronary artery risk development in young adults study (2019) (35)
- Rapamycin retards epigenetic ageing of keratinocytes independently of its effects on replicative senescence, proliferation and differentiation (2019) (35)
- Adipose Co-expression networks across Finns and Mexicans identify novel triglyceride-associated genes (2012) (35)
- Family-based association test method: age of onset traits and covariates. (2001) (34)
- Making sense of the ageing methylome (2022) (34)
- Increased epigenetic age in normal breast tissue from luminal breast cancer patients (2018) (34)
- Reversing age: dual species measurement of epigenetic age with a single clock (2020) (32)
- Functional modules distinguish human induced pluripotent stem cells from embryonic stem cells. (2011) (32)
- Epithelial membrane protein‐2 expression is an early predictor of endometrial cancer development (2010) (32)
- Review of Weighted Gene Coexpression Network Analysis (2011) (31)
- Epigenetic age is a cell‐intrinsic property in transplanted human hematopoietic cells (2019) (31)
- A systems genetic analysis of high density lipoprotein metabolism and network preservation across mouse models. (2012) (30)
- Psychosocial stress and epigenetic aging. (2020) (29)
- Clinical and Plasma Proteomic Markers Correlating With Chronic Kidney Disease After Liver Transplantation (2011) (29)
- Targeted disruption of glycerol kinase gene in mice: expression analysis in liver shows alterations in network partners related to glycerol kinase activity. (2006) (29)
- Gene expression and tissue microarray analysis of interleukin-2 complete responders in patients with metastatic renal cell carcinoma (2005) (28)
- Multivariate variance-components analysis of longitudinal blood pressure measurements from the Framingham Heart Study (2003) (28)
- Dynamics of epigenetic age following hematopoietic stem cell transplantation (2017) (28)
- Microgeographic Proteomic Networks of the Human Colonic Mucosa and Their Association With Inflammatory Bowel Disease (2016) (28)
- Longitudinal study of surrogate aging measures during human immunodeficiency virus seroconversion (2017) (27)
- Transposon-triggered innate immune response confers cancer resistance to the blind mole rat (2021) (27)
- Human Aging DNA Methylation Signatures are Conserved but Accelerated in Cultured Fibroblasts (2019) (27)
- Elevated MED28 expression predicts poor outcome in women with breast cancer (2010) (26)
- The acute effects of adjuvant radiation and chemotherapy on peripheral blood epigenetic age in early stage breast cancer patients (2020) (26)
- DNA methylation study of Huntington’s disease and motor progression in patients and in animal models (2020) (26)
- Castration delays epigenetic aging and feminizes DNA methylation at androgen-regulated loci (2021) (26)
- Genetic dissection of a major mouse obesity QTL (Carfhg2): integration of gene expression and causality modeling. (2009) (26)
- Distinct Neurogenomic States in Basal Ganglia Subregions Relate Differently to Singing Behavior in Songbirds (2012) (26)
- Multi-species and multi-tissue methylation clocks for age estimation in toothed whales and dolphins (2021) (26)
- DNA methylation clocks tick in naked mole rats but queens age more slowly than nonbreeders (2021) (26)
- ARDD 2020: from aging mechanisms to interventions (2020) (25)
- Ribonucleotide Reductase Subunit M2 Predicts Survival in Subgroups of Patients with Non-Small Cell Lung Carcinoma: Effects of Gender and Smoking Status (2015) (25)
- Longitudinal Epigenome-Wide Methylation Study of Cognitive Decline and Motor Progression in Parkinson's Disease. (2019) (25)
- Genetic, Transcriptomic, and Epigenetic Studies of HIV-Associated Neurocognitive Disorder (2014) (24)
- Transcriptome analysis of HIV-infected peripheral blood monocytes: Gene transcripts and networks associated with neurocognitive functioning (2013) (24)
- Season of Sampling and Season of Birth Influence Serotonin Metabolite Levels in Human Cerebrospinal Fluid (2012) (24)
- The Generalized Topological Overlap Matrix for Detecting Modules in Gene Networks (2006) (24)
- Targeting the vascular endothelial growth factor pathway in renal cell carcinoma: A tissue array based analysis (2005) (24)
- Epigenetic clock and methylation studies in elephants (2020) (23)
- Dynamic Tree Cut : in-depth description , tests and applications (2007) (23)
- Epigenetic clock and methylation studies in the rhesus macaque (2020) (23)
- Coffee consumption is associated with DNA methylation levels of human blood (2017) (23)
- A family-based test for correlation between gene expression and trait values. (2003) (23)
- Genomic Profiles and Predictors of Early Allograft Dysfunction After Human Liver Transplantation (2015) (23)
- Expression of the vascular endothelial growth factor family in tumor dissemination and disease free survival in clear cell renal cell carcinoma (2005) (23)
- Seasonal variation of serotonin turnover in human cerebrospinal fluid, depressive symptoms and the role of the 5-HTTLPR (2013) (23)
- Host methylation predicts SARS-CoV-2 infection and clinical outcome (2021) (22)
- A systematic approach to multifactorial cardiovascular disease: causal analysis. (2012) (22)
- Epigenetic Age Acceleration Reflects Long-Term Cardiovascular Health (2021) (22)
- Epigenetic clock and methylation studies in cats (2020) (21)
- Early life adversity, pubertal timing, and epigenetic age acceleration in adulthood. (2021) (21)
- DNA methylation aging and transcriptomic studies in horses (2021) (21)
- Inhibition of Atm and/or Atr disrupts gene silencing on the inactive X chromosome. (2005) (21)
- Epigenetic clock and DNA methylation analysis of porcine models of aging and obesity (2020) (21)
- Epigenetic age and pregnancy outcomes: GrimAge acceleration is associated with shorter gestational length and lower birthweight (2020) (21)
- Na,K-ATPase is a target of cigarette smoke and reduced expression predicts poor patient outcome of smokers with lung cancer. (2012) (20)
- Higher expression levels of 14-3-3sigma in ductal carcinoma in situ of the breast predict poorer outcome. (2009) (19)
- Title Genetic analysis of DNA methylation and gene expression levels in whole blood of healthy human subjects Permalink (2012) (19)
- Inflammation-related genes are associated with epigenetic aging in HIV (2019) (19)
- Higher diet quality relates to decelerated epigenetic aging. (2021) (18)
- Ridge regression based hybrid genetic algorithms for multi-locus quantitative trait mapping (2005) (18)
- Reversal of ageing- and injury-induced vision loss by Tet-dependent epigenetic reprogramming (2019) (17)
- An epigenetic clock to estimate the age of living beluga whales (2020) (17)
- DNA methylation age analysis of rapamycin in common marmosets (2020) (17)
- Epigenetic clocks predict prevalence and incidence of leading causes of death and disease burden (2020) (16)
- Carbonic Anhydrase IX Is an Independent Predictor of Survival in Advanced Renal Clear Cell Carcinoma (2003) (16)
- A Weighted SNP Correlation Network Method for Estimating Polygenic Risk Scores. (2017) (16)
- Gene expression profiling in C57BL/6J and A/J mouse inbred strains reveals gene networks specific for brain regions independent of genetic background (2010) (16)
- Epigenetic clock analysis of human fibroblasts in vitro: effects of hypoxia, donor age, and expression of hTERT and SV40 largeT (2019) (16)
- Assessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study (2021) (16)
- Epigenome-wide association study of diet quality in the Women's Health Initiative and TwinsUK cohort. (2020) (16)
- Genetic and epigenetic changes in clonal descendants of irradiated human fibroblasts (2018) (16)
- Hibernation slows epigenetic ageing in yellow-bellied marmots (2021) (15)
- The relationship between epigenetic age and the hallmarks of aging in human cells (2022) (15)
- Peripheral blood gene expression profiles linked to monoamine metabolite levels in cerebrospinal fluid (2016) (15)
- Epigenetic clock and methylation study of oocytes from a bovine model of reproductive aging (2020) (15)
- Phenotypic Age: a novel signature of mortality and morbidity risk (2018) (15)
- Meta‐analysis of genome‐wide DNA methylation and integrative omics of age in human skeletal muscle (2021) (14)
- Epigenetic clock and methylation studies in vervet monkeys (2020) (14)
- The Effects of Anti-retroviral Therapy on Epigenetic Age Acceleration Observed in HIV-1-infected Adults (2020) (14)
- Increased Menopausal Age Reduces the Risk of Parkinson's Disease: A Mendelian Randomization Approach (2021) (14)
- Vasomotor symptoms and accelerated epigenetic aging in the Women's Health Initiative (WHI). (2020) (14)
- Ki67, gelsolin and PTEN expression in sarcomatoid renal tumors (2003) (13)
- Small extracellular vesicles from young adipose-derived stem cells prevent frailty, improve health span, and decrease epigenetic age in old mice (2022) (13)
- Coagulation factor VIII: Relationship to cardiovascular disease risk and whole genome sequence and epigenome‐wide analysis in African Americans (2020) (13)
- No evidence for association between the KCNQ3 gene and susceptibility to idiopathic generalized epilepsy (2000) (13)
- Future directions of research in statistical genetics. (2000) (13)
- Specific increase of methylation age in osteoarthritis cartilage (2016) (12)
- Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing (2020) (12)
- Meta-analyses identify DNA methylation associated with kidney function and damage (2021) (12)
- Epigenome-wide association study of leukocyte telomere length (2019) (12)
- Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci (2021) (12)
- Epigenetic aging of the demographically non-aging naked mole-rat (2022) (12)
- Uninterrupted CAG repeat drives striatum-selective transcriptionopathy and nuclear pathogenesis in human Huntingtin BAC mice (2022) (11)
- Epigenetic models developed for plains zebras predict age in domestic horses and endangered equids (2021) (11)
- Leukocyte Traits and Exposure to Ambient Particulate Matter Air Pollution in the Women’s Health Initiative and Atherosclerosis Risk in Communities Study (2020) (11)
- A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids (2021) (11)
- Epigenetic predictors of maximum lifespan and other life history traits in mammals (2021) (11)
- Accelerated Epigenetic Aging and Methylation Disruptions Occur in Human Immunodeficiency Virus Infection Prior to Antiretroviral Therapy. (2020) (11)
- DNA Methylation Networks Underlying Mammalian Traits (2021) (11)
- The genetics of gene expression and gene mapping. (2003) (11)
- Immune epigenetic age in pregnancy and 1 year after birth: Associations with weight change (2020) (10)
- Accelerated epigenetic aging in adolescents from low-income households is associated with altered development of brain structures (2020) (10)
- DNAm-based signatures of accelerated aging and mortality in blood are associated with low renal function (2021) (10)
- Correction: A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: A cohort study (2019) (10)
- The acute effects of adjuvant radiation and chemotherapy on peripheral blood epigenetic age in early stage breast cancer patients (2020) (10)
- An epigenome-wide association study of ambient pyrethroid pesticide exposures in California's central valley. (2020) (10)
- Association of 4 epigenetic clocks with measures of functional health, cognition, and all-cause mortality in The Irish Longitudinal Study on Ageing (TILDA) (2020) (10)
- Airway Aging and Methylation Disruptions in HIV-associated Chronic Obstructive Pulmonary Disease. (2022) (9)
- Accelerated hematopoietic mitotic aging measured by DNA methylation, blood cell lineage, and Parkinson’s disease (2021) (9)
- Estimating breast tissue-specific DNA methylation age using next-generation sequencing data (2020) (9)
- OxPhos Dysfunction Causes Hypermetabolism and Reduces Lifespan in Cells and in Patients with Mitochondrial Diseases (2022) (9)
- Blood DNA methylation sites predict death risk in a longitudinal study of 12,300 individuals (2020) (9)
- Epigenetic mutation load is weakly correlated with epigenetic age acceleration (2020) (9)
- DNA methylation signatures in Blood DNA of Hutchinson–Gilford Progeria syndrome (2022) (8)
- Genome-wide changes in lncRNA, alternative splicing, and cortical patterning in autism (2016) (8)
- Genome‐Wide Linkage Analysis in a General Population Sample Using σ2A Random Effects (SSARs) Fitted by Gibbs Sampling (2001) (8)
- DNA methylation patterns of adult survivors of adolescent/young adult Hodgkin lymphoma compared to their unaffected monozygotic twin (2019) (8)
- Gene expression profiling identifies molecular subtypes of gliomas (2006) (8)
- Genetic loci and metabolic states associated with murine epigenetic aging (2022) (8)
- Epigenetic Age and the Risk of Incident Atrial Fibrillation (2021) (7)
- Development of Epigenetic Clocks for Key Ruminant Species (2021) (7)
- Author Correction: Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism (2018) (7)
- LINE-1 RNA causes heterochromatin erosion and is a target for amelioration of senescent phenotypes in progeroid syndromes (2022) (7)
- Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna (2022) (7)
- DNA methylation biomarker for cumulative lead exposure is associated with Parkinson’s disease (2021) (7)
- A multi-omics longitudinal aging dataset in primary human fibroblasts with mitochondrial perturbations (2021) (7)
- Postpartum sleep loss and accelerated epigenetic aging. (2021) (7)
- DNA methylation as a tool to explore ageing in wild roe deer populations (2021) (7)
- Rapamycin treatment during development extends lifespan and healthspan (2022) (7)
- Associations between DNA methylation and BMI vary by metabolic health status: a potential link to disparate cardiovascular outcomes (2021) (7)
- No reliable gene expression biomarkers of current or impending neurocognitive impairment in peripheral blood monocytes of persons living with HIV (2018) (7)
- Chronic Glucocorticoid Stress Reveals Increased Energy Expenditure and Accelerated Aging as Cellular Features of Allostatic Load (2022) (7)
- DNA methylation clocks for dogs and humans (2022) (6)
- Cluster and propensity based approximation of a network (2013) (6)
- Transient non-integrative nuclear reprogramming promotes multifaceted reversal of aging in human cells (2019) (6)
- Telomere length and epigenetic clocks as markers of cellular aging: a comparative study (2022) (6)
- Text-mining applied to autoimmune disease research: the Sjögren’s syndrome knowledge base (2012) (6)
- Correlation and Gene Co-Expression Networks (2011) (6)
- DNA Methylation Age Is More Closely Associated With Infection Risk Than Chronological Age in Kidney Transplant Recipients (2020) (6)
- DNA methylation clocks show slower progression of aging in naked mole-rat queens (2021) (6)
- Accelerated epigenetic aging in newborns with Down syndrome (2022) (6)
- Tutorials for the WGCNA package for R: WGCNA Background and glossary (2011) (6)
- Accurate Epigenetic Aging in Bottlenose Dolphins (Tursiops truncatus), an Essential Step in the Conservation of at-Risk Dolphins (2021) (6)
- Genome Methylation Predicts Age and Longevity of Bats (2020) (5)
- The Effects of Lifetime Estrogen Exposure on Breast Epigenetic Age (2021) (5)
- Title Gene expression profiling in C 57 BL / 6 J and A / J mouse inbred strains reveals gene networks specific for brain regions independent of genetic background Permalink (2010) (5)
- Multi-omic rejuvenation and lifespan extension upon exposure to youthful circulation (2021) (5)
- Integrated Weighted Correlation Network Analysis of Mouse Liver Gene Expression Data (2011) (5)
- 1651: Molecular Prognostic Modeling Using Protein Expression Profile in Clear Cell Renal Carcinoma (2004) (5)
- Biological age is increased by stress and restored upon recovery (2022) (5)
- Accelerated epigenetic aging in adolescents living with HIV is associated with altered development of brain structures (2021) (5)
- Divergent age-related methylation patterns in long and short-lived mammals (2022) (5)
- Schizophrenia is characterized by age- and sex-specific effects on epigenetic aging (2019) (5)
- Pair bonding slows epigenetic aging and alters methylation in brains of prairie voles (2020) (5)
- Genetic Analyses of Epigenetic Predictors that Estimate Aging, Metabolic Traits, and Lifespan (2021) (5)
- DNA methylation study of age and sex in baboons and four other primates (2020) (5)
- Analysis of epigenetic aging in vivo and in vitro: Factors controlling the speed and direction (2020) (5)
- Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus (2021) (5)
- HIV, pathology and epigenetic age acceleration in different human tissues (2022) (5)
- DNA-methylation-based telomere length estimator: comparisons with measurements from flow FISH and qPCR (2021) (5)
- OxPhos defects cause hypermetabolism and reduce lifespan in cells and in patients with mitochondrial diseases (2023) (5)
- PRC2 clock: a universal epigenetic biomarker of aging and rejuvenation (2022) (4)
- Analysis of Epigenetic Age Acceleration and Healthy Longevity Among Older US Women (2022) (4)
- Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells (2020) (4)
- Methylation studies in Peromyscus: aging, altitude adaptation, and monogamy (2021) (4)
- Predicting COPD status with a random generalized linear model (2013) (4)
- An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease (2016) (4)
- Optimism is not associated with two indicators of DNA methylation aging (2019) (4)
- Meta-analysis of genome-wide DNA methylation and integrative OMICs in human skeletal muscle (2020) (4)
- The disequilibrium maximum-likelihood-binomial test does not replace the transmission/disequilibrium test. (2000) (4)
- The relationship between the epigenetic aging biomarker “grimage” and lung function in both the airway and blood of people living with HIV: An observational cohort study (2022) (4)
- Pan-primate DNA methylation clocks (2021) (4)
- Epigenetic Aging and Hematopoietic Cell Transplantation in Patients With Severe Aplastic Anemia. (2021) (4)
- Increased Rate of Epigenetic Aging in Men Living With HIV Prior to Treatment (2022) (4)
- Causal Epigenetic Age Uncouples Damage and Adaptation (2022) (4)
- An epigenome-wide association study of educational attainment (n = 10,767) (2017) (3)
- Epigenetic age is accelerated in schizophrenia with age- and sex-specific effects and associated with polygenic disease risk (2019) (3)
- Finding the best ridge regression subset by genetic algorithms: applications to multilocus quantitative trait mapping (2004) (3)
- Tutorial for the WGCNA package for R : III . Using simulated data to evaluate different module detection methods and gene screening approaches 7 . Module membership , intramodular connectivity and screening for intramodular hub genes (2011) (3)
- Multi-Tissue Methylation Clocks for Age and Sex Estimation in the Common Bottlenose Dolphin (2021) (3)
- Umbilical cord plasma concentrate has beneficial effects on DNA methylation GrimAge and human clinical biomarkers (2022) (3)
- Accelerated aging with HIV begins at the time of initial HIV infection (2022) (3)
- Combining Multiple Phenotypic Traits Optimally for Detecting Linkage with Sib‐Pair Observations (2001) (3)
- Occurrence of Accelerated Epigenetic Aging and Methylation Disruptions in Human Immunodeficiency Virus Infection Before Antiretroviral Therapy (2021) (3)
- Plasma lipid profiles in early adulthood are associated with epigenetic aging in the Coronary Artery Risk Development in Young Adults (CARDIA) Study (2022) (3)
- Epigenetic age and pregnancy outcomes: GrimAge acceleration is associated with shorter gestational length and lower birthweight (2020) (3)
- A High‐throughput Targeted Bisulfite Sequencing‐based Analysis for Epigenetic Age Quantification and Monitoring (2018) (3)
- Author Correction: DNA methylation predicts age and provides insight into exceptional longevity of bats (2021) (3)
- Epigenetic clock and DNA methylation studies of roe deer in the wild (2020) (3)
- Epigenetic clock and methylation studies in dogs (2021) (3)
- DNA methylation clock DNAmFitAge shows regular exercise is associated with slower aging and systemic adaptation (2022) (3)
- Erratum to: DNA methylation age of human tissues and cell types (2015) (3)
- Premature aging is associated with higher levels of 8‐oxoguanine and increased DNA damage in the Polg mutator mouse (2022) (3)
- Author response: Neuropathological and transcriptomic characteristics of the aged brain (2017) (3)
- A systematic evaluation of 41 DNA methylation predictors across 101 data preprocessing and normalization strategies highlights considerable variation in algorithm performance (2021) (3)
- Refining epigenetic prediction of chronological and biological age (2022) (3)
- Aging the brain: multi-region methylation principal component based clock in the context of Alzheimer’s disease (2022) (3)
- Additive Effects of Stress and Alcohol Exposure on Accelerated Epigenetic Aging in Alcohol Use Disorder (2022) (3)
- Epigenetic clock and methylation studies in marsupials: opossums, Tasmanian devils, kangaroos, and wallabies (2022) (2)
- 621: Molecular Tumor Grading of Clear Cell Renal Cell Carcinoma Using Protein Expression of the Vascular Endothelial Growth Factor (VEGF) Family (2005) (2)
- The Multi-Node Topological Overlap Measure For Gene Neighborhood Analysis (2006) (2)
- Correction to: A candidate gene study of intermediate histopathological phenotypes in HIV-associated neurocognitive disorders (2020) (2)
- DNA methylation aging and transcriptomic studies in horses (2022) (2)
- An epigenetic DNA methylation clock for age estimates in Indo‐Pacific bottlenose dolphins (Tursiops aduncus) (2022) (2)
- Genome-wide association studies identify 137 loci for DNA methylation biomarkers of aging (2020) (2)
- Castration delays epigenetic aging and feminises DNA methylation at androgen-regulated loci (2020) (2)
- DNA methylation-based surrogates of plasma proteins are associated with Parkinson's disease risk (2021) (2)
- Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging (2021) (2)
- DNAmFitAge: Biological Age Indicator Incorporating Physical Fitness (2022) (2)
- Significant variation in the performance of DNA methylation predictors across data preprocessing and normalization strategies (2022) (2)
- Title Network methods for describing sample relationships in genomic datasets : application to Huntington ' s disease Permalink (2012) (2)
- Networks and Fundamental Concepts (2011) (2)
- Association of subjective social status with epigenetic aging among Black and White women (2022) (2)
- Family‐based association for quantitative traits. (2014) (2)
- Tissue Microarrays: Construction and Utilization for Biomarker Studies (2008) (2)
- Inflammation-Related Genes are Associated with Accelerated Aging in HIV (2018) (2)
- Association of Epigenetic Age Acceleration with Incident Mild Cognitive Impairment and Dementia Among Older Women. (2021) (2)
- Marijuana use and DNA methylation-based biological age in young adults (2022) (2)
- Epigenetic models predict age and aging in plains zebras and other equids (2021) (2)
- Author response: Maintenance of age in human neurons generated by microRNA-based neuronal conversion of fibroblasts (2016) (2)
- Comparison of Clustering Methods for Time Course Genomic Data: Applications to Aging Effects (2014) (2)
- Geometric Interpretation of Correlation Networks Using the Singular Value Decomposition (2011) (1)
- Adipose Co-expression networks across Finns and Mexicans identify novel triglyceride-associated genes (2012) (1)
- Erratum to “Increased Menopausal Age Reduces the Risk of Parkinson's Disease: A Mendelian Approach” (2022) (1)
- Leukocyte telomere length , T cell composition and DNA methylation (2017) (1)
- Corrected R code from chapter 12 of the book (2013) (1)
- University of Southern Denmark Prenatal and early life influences on epigenetic age in children (2015) (1)
- Epigenetic age provides insight into tissue origin in endometriosis (2019) (1)
- Epigenome-Wide Analysis of DNA Methylation and Optimism in Women and Men (2022) (1)
- Association Measures and Statistical Significance Measures (2011) (1)
- Random generalized linear model: a highly accurate and interpretable ensemble predictor (2013) (1)
- Clinical, pathological, and molecular correlations of necrosis in the primary tumor of patients with renal cell carcinoma (2004) (1)
- Clustering Procedures and Module Detection (2011) (1)
- The association of epigenetic age acceleration and multimorbidity at age 90 in the Women's Health Initiative. (2022) (1)
- 30 SCHIZOPHRENIA IS CHARACTERIZED BY AGE- AND SEX-SPECIFIC EFFECTS ON EPIGENETIC AGING (2019) (1)
- Genes and pathways underlying regional and cell type changes in Alzheimer's disease (2013) (1)
- An epigenetic clock for gestational age at birth based on blood methylation data (2016) (1)
- Intraindividual variability in neurocognitive performance: No influence due to HIV status or self-reported effort (2018) (1)
- Publisher Correction: A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids (2021) (1)
- A candidate gene study of intermediate histopathological phenotypes in HIV-associated neurocognitive disorders (2020) (1)
- Reversal of aging-induced and glaucoma-induced vision loss by in vivo epigenetic reprogramming (2020) (1)
- Aging effects on DNA methylation modules in human brain and blood tissue (2012) (1)
- Epigenetic clock and methylation studies in gray short-tailed opossums (2021) (1)
- An Analysis of Methylome Evolution in Primates (2021) (1)
- Structural Equation Models and Directed Networks (2011) (1)
- Hippocampal DNA Methylation, Epigenetic Age and Spatial Memory Performance in Young And Old Rats. (2022) (1)
- No strong association among epigenetic modifications by DNA methylation, telomere length, and physical fitness in biological aging (2023) (1)
- Title Ribonucleotide Reductase Subunit M 2 Predicts Survival in Subgroups of Patients with Non-Small Cell Lung Carcinoma : Effects of Gender and Smoking Status Permalink (2015) (1)
- Epigenetics and island-mainland divergence in an insectivorous small mammal (2022) (1)
- Evaluating Whether a Module is Preserved in Another Network (2011) (1)
- Alcohol consumption and epigenetic age acceleration in young adults (2023) (1)
- Genetic analysis of DNA methylation and gene expression levels in whole blood of healthy human subjects (2012) (1)
- Epigenetic profiling and incidence of disrupted development point to gastrulation as aging ground zero in Xenopus laevis (2022) (1)
- AN EPIGENETIC CLOCK FOR AGING AND LIFE EXPECTANCY (2018) (1)
- Stochastic Epigenetic Mutations Influence Parkinson’s Disease Risk, Progression, and Mortality (2021) (1)
- Pesticide Exposure, Systems Biology, and Parkinson’s disease (2021) (1)
- EPIGENETIC AGING OF THE DEMOGRAPHICALLY NONAGING NAKED MOLE RAT (2022) (1)
- Multi-tissue methylation clocks for age estimation in the common bottlenose dolphin (2021) (1)
- Overexpression of inhibitor of apoptosis protein XIAP in human prostate cancer (2005) (1)
- University of Groningen Gene expression profiling in C 57 BL / 6 J and A / J mouse inbred strains reveals gene networks specific for brain regions independent of genetic background (2018) (1)
- Systems Biology Analysis of Sjögren’s Syndrome and MALT Lymphoma Development in Parotid Glands (2008) (1)
- Family-based Association for Quantitative Traits (2005) (1)
- Incorporation of a nucleoside analog maps genome repair sites in post-mitotic human neurons (2020) (1)
- 372: Expression Analysis of the Vascular Endothelial Growth Factor (VEGF) Family in Renal Cell Carcinoma: Targeting the VEGF Pathway (2006) (1)
- 1331: Expression of Vascular Endothelial Growth Factor A (VEGF-A), VEGF Receptor 1 (VEGFR-1) and VEGFR-2 in Clear Cell and Papillary Renal Cell Carcinoma (RCC): Implications for Therapy (2005) (1)
- Abstracts of the AST (American Society of Transplantation) Annual Scientific Exchange. December 2-6, 2009. Orlando, Florida, USA. (2010) (1)
- DNA methylation GrimAge version 2 (2022) (1)
- A molecular signature defining exercise adaptation with ageing and in vivo partial reprogramming in skeletal muscle (2022) (1)
- Alcohol use disorder is associated with DNA methylation-based shortening of telomere length and regulated by TESPA1: implications for aging (2021) (1)
- Adjacency Functions and Their Topological Effects (2011) (1)
- DNA methylation age of blood predicts all-cause mortality in later life (2015) (0)
- The influence of biological and statistical properties of CpGs on epigenetic predictions of eighteen traits (2022) (0)
- Small extracellular vesicles from young mice prevent frailty, improve healthspan and decrease epigenetic age in old mice (2021) (0)
- Estimating breast tissue-specific DNA methylation age using next-generation sequencing data (2020) (0)
- Methylation studies in Peromyscus: aging, altitude adaptation, and monogamy (2021) (0)
- The Blood DNA Methylation Clock GrimAge Is a Robust Surrogate for Airway Epithelia Aging (2022) (0)
- An analysis of methylome evolution in 1 primates 2 (2021) (0)
- Identification of influential probe types in epigenetic predictions of human traits: implications for microarray design (2022) (0)
- Accelerated epigenetic aging in brain is associated with pre-mortem HIV-associated neurocognitive disorders (2015) (0)
- Association of blood‐based epigenetic age acceleration with cognitive impairment and brain outcomes by cardiovascular disease among women (2021) (0)
- DNA methylation-based biomarkers and the epigenetic clock theory of ageing (2018) (0)
- Plasma lipid profiles in early adulthood are associated with epigenetic aging in the Coronary Artery Risk Development in Young Adults (CARDIA) Study (2022) (0)
- Identification of influential probe types in epigenetic predictions of human traits: implications for microarray design (2022) (0)
- Chronic Exposure to Youthful Circulation Leads to Epigenetic Reprogramming and Lifespan Extension (2021) (0)
- DISCOVERY AND VALIDATION OF PERIPHERAL BLOOD DIAGNOSTIC BIOMARKERS FOR ACUTE KIDNEY REJECTION: REPORT OF THE TGCG STUDY.: 688 (2010) (0)
- DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases (2016) (0)
- Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci (2021) (0)
- The impact of reproductive factors on DNA methylation-based telomere length in healthy breast tissue (2022) (0)
- Accelerated hematopoietic mitotic aging measured by DNA methylation, blood cell lineage, and Parkinson’s disease (2021) (0)
- Epigenetic measures of ageing predict the prevalence and incidence of leading causes of death and disease burden (2020) (0)
- Edinburgh Explorer Epigenetic measures of ageing predict prevalence and incidence of leading causes of death and disease burden (2020) (0)
- DNA methylation biomarker for cumulative lead exposure is associated with Parkinson’s disease (2021) (0)
- Systematic evaluation of DNA methylation age estimation with common preprocessing methods and the Infinium MethylationEPIC BeadChip array (2018) (0)
- Metabolic and inflammatory biomarkers are associated with epigenetic aging acceleration estimates in the GOLDN study (2018) (0)
- Author Correction: Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism (2023) (0)
- Epigenetic age acceleration and metabolic syndrome in the coronary artery risk development in young adults study (2019) (0)
- Telomere length and epigenetic clocks as markers of cellular aging: a comparative study (2022) (0)
- Associations between DNA methylation and BMI vary by metabolic health status: a potential link to disparate cardiovascular outcomes (2021) (0)
- DNA methylation profile in beef cattle is influenced by additive genetics and age (2022) (0)
- DNAm-based signatures of accelerated aging and mortality in blood are associated with low renal function (2021) (0)
- Alteration in basal and depolarization induced transcriptional network in iPSC derived neurons from Timothy syndrome (2014) (0)
- DNA methylation aging clocks: challenges and recommendations (2019) (0)
- Synchrony and asynchrony between an epigenetic clock and developmental timing (2019) (0)
- Parkinson’s disease is associated with DNA methylation levels in human blood and saliva (2017) (0)
- Systems analysis of human brain gene expression: mechanisms for HIV-associated neurocognitive impairment and common pathways with Alzheimer’s disease (2013) (0)
- Decision letter: Proteomic and transcriptomic profiling reveal different aspects of aging in the kidney (2020) (0)
- Centenarian clocks: epigenetic clocks for validating claims of exceptional longevity. (2023) (0)
- The Circulating Level of Klotho Is Not Dependent upon Physical Fitness and Age-Associated Methylation Increases at the Promoter Region of the Klotho Gene (2023) (0)
- ERCC1 mice, unlike other premature aging models, display accelerated epigenetic age (2022) (0)
- DNA methylation and cardiovascular disease in humans: a systematic review and database of known CpG methylation sites (2023) (0)
- GWAS of epigenetic aging rates in blood reveals a critical role for TERT (2018) (0)
- Multi-tissue DNA methylation aging clocks for sea lions, walruses and seals (2023) (0)
- Abstract P5-03-09: Cell composition changes in healthy breast tissue is associated with advancing age and epigenetic age acceleration (2023) (0)
- A meta-analysis of genome-wide association studies of epigenetic age 2 acceleration (2019) (0)
- Associations between cardiorespiratory fitness and lifestyle-related factors with DNA methylation-based aging clocks in older men: WASEDA'S Health Study (2023) (0)
- Title: Atherosclerotic plaque epigenetic age acceleration is characterized by mesenchymal reprogramming and poor prognosis Short title: Epigenetic age acceleration in female and male atherosclerotic plaques (2023) (0)
- Corrigendum to “Association of subjective social status with epigenetic aging among Black and White women” [Psychoneuroendocrinology, 141 (2022), 105748] (2022) (0)
- Identification, Control and Prevention of Work-related Psychosocial Hazards and Social Conditions Contributing to Mental Health Disorders and Prolonged Work Absence (2016) (0)
- Pleiotropic Influence of DNA Methylation QTLs on physiological and aging traits (2023) (0)
- Multi-species and multi-tissue methylation clocks for age estimation in toothed whales and dolphins (2021) (0)
- Abstract P2-11-06: Differential gene expression patterns in healthy breast tissue exhibiting epigenetic age acceleration (2022) (0)
- Prostate StemCell Antigen Is Overexpressed in Prostate (2005) (0)
- Abstract P2-04-02: Comparison of DNA methylation patterns in normal breast tissue from women with and without breast cancer (2018) (0)
- 636: Hematogenous Versus Lymphatic Dissemination: The Role of the Vascular Endothelial Growth Factor (VEGF) Family in the Metastatic Process of Clear Cell Renal Cell Carcinoma (2005) (0)
- METHYLATION LANDSCAPES UNDERLYING HUMAN BIOLOGICAL AGING (2018) (0)
- PI 3 K / Akt pathway activation in glioblastoma and prostate cancer Insulin growth factor-binding protein 2 is a candidate biomarker for PTEN status and (2007) (0)
- Abstract 1444: Weighted Gene Co-expression Network Analysis of Adipose and Liver Reveals Gene Modules Related to Plasma HDL Levels and Containing Candidate Genes at Loci Identified in Genome Wide Association Studies (2008) (0)
- Networks Between Categorical or Discretized Numeric Variables (2011) (0)
- ' s response to reviews Title : Adipose Transcript Networks Across Finns and Mexicans Identify Novel Triglyceride-Associated Genes (2012) (0)
- Title No reliable gene expression biomarkers of current or impending neurocognitive impairment in peripheral blood monocytes of persons living with HIV (2018) (0)
- Epigenetics and human aging (2017) (0)
- DNA Methylation Differences in Twins Discordant for Adolescent/Young Adult Hodgkin Lymphoma (2015) (0)
- Additional file 1 : Methods description (2012) (0)
- Epigenomic signature of the progeroid Cockayne syndrome exposes distinct and common features with physiological ageing (2021) (0)
- Author Correction: DNA methylation predicts age and provides insight into exceptional longevity of bats (2022) (0)
- The analysis of epigenomic evolution (2021) (0)
- EPIGENETIC PREDICTORS OF LIFESPAN AND HEALTHSPAN (2019) (0)
- DNA methylation based biomarkers for aging long-lived cetaceans. (2023) (0)
- Development and application of tissue microarrays for biomarker studies (2011) (0)
- A Network-Based Gene Screening Approach For Improving the Validation Success of Microarrays (2006) (0)
- Abstract 4299: Poor prognosis in smokers with non-small cell lung cancer correlates with the presence of a reparative progenitor cell population (2010) (0)
- Genetic And Pharmacological Manipulation Of Stat3 Changes The Epigenetic Age In Articular Chondrocyte Development And Disease (2023) (0)
- Tu1983 Comprehensive Inter-Omic Analysis Reveals Exquisite Metabolite-Driven Microbial Relationships (2013) (0)
- A gene co-expression module in peripheral blood correlates with hippocampal atrophy in elderly subjects (2013) (0)
- Title High expression of AGR 2 in lung cancer is predictive of poor survival (2015) (0)
- DNA methylation age of human tissues and cell types (2013) (0)
- 1332: Complete Reponse to Immunotherapy in Metastatic Renal Cell Carcinoma: Gene Expression and Tissue Microarray Analysis (2005) (0)
- The impact of reproductive factors on DNA methylation-based telomere length in healthy breast tissue (2022) (0)
- Abstract # 3196 Maternal sleep loss in postpartum associated with accelerated epigenetic aging (2019) (0)
- A gene coexpression module in peripheral blood correlates with hippocampal atrophy in elderly individuals (2013) (0)
- Networks Based on Regression Models and Prediction Methods (2011) (0)
- Simulation of gene expression data (2007) (0)
- Development of epigenetic clocks for New Zealand livestock (2021) (0)
- Abstract 4444: DNA methylation age is accelerated in breast tissue of healthy women donors (2016) (0)
- The Relationship Between Intramodular Connectivity and Gene Significance in Co-Expression Networks (2006) (0)
- Abstract A136: A systems approach to the preclinical evaluation of targeted chemoprevention for lung cancer (2008) (0)
- Epigenome-wide Association Study of Diet Quality in the Women's Health Initiative (OR31-06-19). (2019) (0)
- Epigenome-wide meta-analysis of BMI in nine cohorts: examining the utility of epigenetic BMI in predicting metabolic health (2022) (0)
- Identification of shared molecular pathways involved in autism by brain transcriptome profiling (2010) (0)
- 2134 DIFFERENTIAL EXPRESSION OF AGR2 AND CD10 IN PROSTATE CANCER (2013) (0)
- Tumor Clustering and Gene Selection Techniques-A Survey (2016) (0)
- Author response: Castration delays epigenetic aging and feminizes DNA methylation at androgen-regulated loci (2021) (0)
- Abstract PS7-28: Association between epigenetic age acceleration and postmenopausal breast cancer risk in the Women’s Health Initiative (2021) (0)
- Additional File 1 : Single Edge Simulations for Evaluating the NEO software (2008) (0)
- Organophosphate Pesticide Exposure, Differential Genome-Wide DNA Methylation, and Biologic Function (2018) (0)
- DNA methylation clocks for clawed frogs reveal evolutionary conservation of epigenetic ageing (2022) (0)
- Genome-wide DNA methylation and multi-omics study of human chondrocyte ontogeny and an epigenetic clock analysis of adult chondrocytes (2021) (0)
- P1-140 SOLUBLE BACE ACTIVITYAND SAPPb LEVELS DO NOT DIFFERENTIATE ALZHEIMER’S DISEASE AND AGE-MATCHED CONTROL CEREBROSPINAL FLUID IN THEADNI-1 COHORT (2013) (0)
- Ambient ultrafine PM chemicals enhance expression of genes related to vascular inflammation (2011) (0)
- Title Systems analysis of human brain gene expression : mechanisms for HIV-associated neurocognitive impairment and common pathways with Alzheimer ¿ s disease (2013) (0)
- Inflammation-related genes are associated with epigenetic aging in HIV (2019) (0)
- 1337: Endothelial Expression of Vascular Endothelial Growth Factor Receptor 3 (VEGFR-3), but not VEGFR-1 or VEGFR-2, Predicts Survival in Clear Cell Renal Cell Carcinoma (RCC) (2005) (0)
- 2047 DECREASED LEVELS OF AGR2 AND INCREASED LEVELS OF CD10 IN PATIENTS WITH HIGH-STAGE PROSTATE CANCER PREDICT THE POOREST SURVIVAL (2010) (0)
- Identification of seed-specific transcription factors from a global analysis of gene activity during the Arabidopsis life cycle (2005) (0)
- TAMI-39. AGE-DEPENDENT PHENOTYPIC CONVERSION FROM NEURONAL ACTIVITY TO NEURO-INFLAMMATION IN GLIOBLASTOMA PROGRESSION (2020) (0)
- Additional file 6: of An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease (2016) (0)
- 150 THE NATURAL HISTORY OF ULTRASENSITIVE PSA FOLLOWING RADICAL PROSTATECTOMY (2011) (0)
- Empirical evaluation of prediction- and correlation network methods applied to genomic data (2014) (0)
- 521 UTEROPLACENTAL INSUFFICIENCY ALTERS EXPRESSION OF EPH A8 IN THE BRAIN OF INTRAUTERINE GROWTH RESTRICTED RATS. (2004) (0)
- Mammalian Co-methylation Network Analysis of Species Characteristics (2021) (0)
- ischemiaexpression profile in mouse myocardium after (2015) (0)
- Host methylation predicts SARS-CoV-2 infection and clinical outcome. (2021) (0)
- Pathway profiling of obesity using the Weighted Interaction SNP Hub (WISH) network method (2013) (0)
- An Epigenome-Wide Analysis of Ambient Pyrethroid Pesticide Exposures in California's Central Valley (2020) (0)
- Increased epigenetic age in normal breast tissue from luminal breast cancer patients (2018) (0)
- Constructing Networks from Matrices (2011) (0)
- PSIII-7 Relationship of Age and Genetics with the Methylation Profile of Beef Cattle (2021) (0)
- Epigenetically mediated electrocardiographic manifestations of sub-chronic exposures to ambient particulate matter air pollution in the Women's Health Initiative and Atherosclerosis Risk in Communities Study. (2021) (0)
- Abstract P1-09-08: Hormonal factors associated with elevation of DNA methylation age in breast tissue of healthy women (2019) (0)
- STAT3 promotes a youthful epigenetic state in articular chondrocytes (2023) (0)
- Genome-wide DNA methylation and Organophosphate pesticide exposure in Central California Parkinson’s disease patients and healthy controls (2016) (0)
- HIPPOCAMPAL DNA METHYLATION, DNAm AGE AND SPATIAL MEMORY PERFORMANCE IN YOUNG AND OLD RATS (2021) (0)
- Abstract P101: Methylome-wide Association Study Provides Evidence of Particulate Matter Air Pollution-associated Dna Methylation at Cardiovascular Disease-related Genes (2018) (0)
- Epigenetic age analysis of human children who seem to evade aging (2015) (0)
- University of Groningen Mapping of Gene Expression Reveals CYP 27 A 1 as a Susceptibility Gene for Sporadic (2012) (0)
- Epigenome-wide meta-analysis of BMI in nine cohorts: Examining the utility of epigenetically predicted BMI. (2023) (0)
- Comparing Robust Methods for Defining Directed Networks and Their Hub Nodes (2010) (0)
- 972: Clinical, Pathologic, and Molecular Correlations of Necrosis in the Primary Tumor of Patients with Renal Cell Carcinoma (2005) (0)
- 315 Molecular signature of the PTEN tumor suppressor-identification of IGFBP2 as a surrogate marker for PTEN/Akt signaling (2004) (0)
- Different Types of Network Concepts (2011) (0)
- Network Based on the Joint Probability Distribution of Random Variables (2011) (0)
- YOUNG PLASMA REJUVENATES BLOOD DNA METHYLATION PROFILE, PROLONGS MEAN LIFESPAN AND IMPROVES HEALTH IN OLD RATS (2022) (0)
- High expression of AGR2 in lung cancer is predictive of poor survival (2015) (0)
- SAT0002 Specific Premature Epigenetic Aging of Cartilage in Osteoarthritis (2016) (0)
- Comparative epigenome analysis using Infinium DNA methylation BeadChips (2023) (0)
- Accelerated epigenetic aging and DNA methylation alterations in Berardinelli-Seip congenital lipodystrophy. (2023) (0)
- 349: Vascular Endothelial Growth Factor Receptor 3 (VEGFR-3) is Preferentially Expressed in Papillary Renal Cell Carcinoma (RCC). (2005) (0)
- Approximately Factorizable Networks (2011) (0)
- Abstract MP61: A Multi-pollutant, Multi-ethnic, and Methylome-wide Association Study Highlights Epigenetic Effects of Exposure to Ambient Air Pollution Mixtures (2018) (0)
- Comparison of epigenetic aging in normal breast tissue from women with and without breast cancer. (2017) (0)
- 551. Demonstrating the use of a mammalian methylation microarray for epigenome wide association studies in livestock (2022) (0)
- EPIGENETIC CLOCKS OF COMPUTED TOMOGRAPHY MEASURES OF FATTY ORGANS (2019) (0)
- DNA methylation age studies of humpback whales (2022) (0)
- F124EPIGENETIC AGING IN BLOOD IS AFFECTED IN SCHIZOPHRENIA (2019) (0)
- Characterizing Complete Responders to IL-2 Using Gene Expression Analysis and Tissue Array Validation in Patients with Metastatic Renal Cell Carcinoma (2004) (0)
- Higher testosterone and testosterone/estradiol ratio in men are associated with better epigenetic estimators of mortality risk (2023) (0)
- The distribution of genes for different pathways in the gene coexpression network modules (2011) (0)
- Supplementary text S 1 : Methods description and relationships between module preservation statistics (2010) (0)
- Title : Differential expression of anterior gradient gene AGR 2 in prostate cancer (2010) (0)
- Clinical, pathological, and molecular correlations of necrosis in the primary tumor of patients with renal cell carcinoma. (2004) (0)
- Global changes in patterning, splicing and primate specific lncRNAs in autism brain (2016) (0)
- Comparison studies on simulated data (2010) (0)
- following targeted MAP kinase activation Distinct gene expression profiles in adult mouse heart (2015) (0)
- M47 EPIGENETIC AGE ACCELERATION IN ALCOHOL USE DISORDER: EVIDENCE FOR A NOVEL ROLE OF APOL2 (2019) (0)
- 680Hematogenous versus lymphatic dissemination: The role of the vascular endothelial growth factor (VEGF) family in the metastatic process of clear cell renal cell carcinoma (2005) (0)
- Additional file 3 : Polynomial and spline regression models for estimating non-linear relationships in real data application (2012) (0)
- No reliable gene expression biomarkers of current or impending neurocognitive impairment in peripheral blood monocytes of persons living with HIV (2018) (0)
- Gene expression profiling identifies altered networks in late-onset Alzheimer’s disease: Immune response and mitochondrial process (2015) (0)
- 645: Vascular Endothelial Growth Factor Receptor 3 (VEGFR-3) is Highly Expressed in the Tumor Endothelium of Clear Cell but not Papillary Renal Cell Carcinoma (RCC): Implications for Therapy (2005) (0)
- Abstract 903: Expression of estrogen receptor beta together with aromatase predicts survival in non-small cell lung cancer (2011) (0)
- Towards epigenomic and metabolomic profiles of chronic organophosphate exposure in residents of California’ Central Valley (2021) (0)
- ABERRANT GENE PROMOTER HYPERMETHYLATION IN THE URINE AS A BIOMARKER OF ATN DURING KIDNEY (2006) (0)
- P53 is an independent predictor of tumor recurrence and progression after nephrectomy for patients with localized Renal Cell Carcinoma: Implications for surveillance and adjuvant clinical trials. (2004) (0)
- Low CD 38 Identifies Proge nitor-like Inflammation-Associated Luminal Cells that Can Initiate Human Prostate Cancer and Predict Poor Outcome Graphical Abstract Highlights (2016) (0)
- DNA methylation age in paired tumor and adjacent normal breast tissue in Chinese women with breast cancer (2023) (0)
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