Steven A Benner

Steven A Benner's AcademicInfluence.com Rankings

Steven A Benner

Chemistry

#2650

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#3583

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Organic Chemistry

#397

World Rank

#469

Historical Rank

chemistry Degrees

Steven A Benner

Biology

#7443

World Rank

#10373

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Evolutionary Biology

#172

World Rank

#193

Historical Rank

Molecular Biology

#862

World Rank

#885

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Biochemistry

#1030

World Rank

#1144

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biology Degrees

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Steven A Benner's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

The potential and challenges of nanopore sequencing (2008) (2197)
Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease. (2007) (982)
Exhaustive matching of the entire protein sequence database. (1992) (854)
Enzymatic incorporation of a new base pair into DNA and RNA extends the genetic alphabet (1990) (498)
Borate Minerals Stabilize Ribose (2004) (486)
Modern metabolism as a palimpsest of the RNA world. (1989) (408)
The missing organic molecules on Mars. (2000) (355)
Understanding nucleic acids using synthetic chemistry. (2004) (326)
Resurrecting ancestral alcohol dehydrogenases from yeast (2005) (306)
Enzymatic incorporation of a new base pair into DNA and RNA (1989) (275)
The challenges of sequencing by synthesis (2009) (260)
Inferring the palaeoenvironment of ancient bacteria on the basis of resurrected proteins (2003) (246)
Reconstructing the evolutionary history of the artiodactyl ribonuclease superfamily (1995) (245)
Hachimoji DNA and RNA: A genetic system with eight building blocks (2019) (243)
In vitro selection with artificial expanded genetic information systems (2013) (231)
Is there a common chemical model for life in the universe (2004) (221)
Amplification, mutation, and sequencing of a six-letter synthetic genetic system. (2011) (220)
Empirical and structural models for insertions and deletions in the divergent evolution of proteins. (1993) (217)
Asphalt, water, and the prebiotic synthesis of ribose, ribonucleosides, and RNA. (2012) (196)
Locked nucleic acid molecular beacons. (2005) (192)
Enzymatic recognition of the base pair between isocytidine and isoguanosine. (1993) (190)
Synthesis of carbohydrates in mineral-guided prebiotic cycles. (2011) (181)
Synthesis, structure and activity of artificial, rationally designed catalytic polypeptides (1993) (179)
Signatures of a shadow biosphere. (2009) (170)
Amino acid substitution during functionally constrained divergent evolution of protein sequences. (1994) (168)
The "strong" RNA world hypothesis: fifty years old. (2013) (166)
Patterns of divergence in homologous proteins as indicators of secondary and tertiary structure: a prediction of the structure of the catalytic domain of protein kinases. (1991) (156)
Predicting functional divergence in protein evolution by site-specific rate shifts. (2002) (152)
Artificially expanded genetic information system: a new base pair with an alternative hydrogen bonding pattern (2006) (152)
Oligonucleotides containing flexible nucleoside analogs (1990) (148)
Evolution of functional six-nucleotide DNA. (2015) (142)
Lessons from comparative physiology: could uric acid represent a physiologic alarm signal gone awry in western society? (2008) (142)
Enzymatic incorporation of a third nucleobase pair (2007) (130)
The NASA Astrobiology Roadmap. (2003) (126)
The use of thymidine analogs to improve the replication of an extra DNA base pair: a synthetic biological system (2005) (122)
Function-structure analysis of proteins using covarion-based evolutionary approaches: Elongation factors. (2001) (114)
Phosphates, DNA, and the search for nonterrean life: a second generation model for genetic molecules. (2002) (112)
Planetary Biology--Paleontological, Geological, and Molecular Histories of Life (2002) (109)
Nucleobase pairing in expanded Watson-Crick-like genetic information systems. (2003) (107)
Defining life. (2010) (107)
Expanded genetic alphabets in the polymerase chain reaction. (2010) (99)
Hominids adapted to metabolize ethanol long before human-directed fermentation (2014) (92)
The ribonuclease from an extinct bovid ruminant (1990) (92)
Structural basis for a six nucleotide genetic alphabet. (2015) (89)
Quantitative analysis of receptors for adenosine nucleotides obtained via in vitro selection from a library incorporating a cationic nucleotide analog. (1999) (89)
A Review: Synthesis of Aryl C-Glycosides Via the Heck Coupling Reaction (2006) (87)
Building blocks for oligonucleotide analogues with dimethylene sulfide, sulfoxide, and sulfone groups replacing phosphodiester linkages (1991) (87)
Point of sampling detection of Zika virus within a multiplexed kit capable of detecting dengue and chikungunya (2017) (87)
Recognition by viral and cellular DNA polymerases of nucleosides bearing bases with nonstandard hydrogen bonding patterns. (1995) (86)
A mechanistic basis for the stereoselectivity of enzymic transfer of hydrogen from nicotinamide cofactors (1983) (85)
The planetary biology of ascorbate and uric acid and their relationship with the epidemic of obesity and cardiovascular disease. (2008) (83)
Empirical analysis of protein insertions and deletions determining parameters for the correct placement of gaps in protein sequence alignments. (2004) (83)
PCR amplification of DNA containing non-standard base pairs by variants of reverse transcriptase from Human Immunodeficiency Virus-1. (2004) (81)
Is there a common chemical model for life in the universe? (2004) (80)
Planetary organic chemistry and the origins of biomolecules. (2010) (74)
The Adaptive Evolution Database (TAED) (2001) (74)
Enzyme kinetics and molecular evolution (1989) (73)
Synthetic biology: Act natural (2003) (73)
Total synthesis and cloning of a gene coding for the ribonuclease S protein. (1984) (72)
Reconstructed evolutionary adaptive paths give polymerases accepting reversible terminators for sequencing and SNP detection (2010) (72)
An analysis of simultaneous variation in protein structures. (1997) (71)
Prebiotic stereoselective synthesis of purine and noncanonical pyrimidine nucleotide from nucleobases and phosphorylated carbohydrates (2017) (69)
Patterns of divergence in homologous proteins as indicators of tertiary and quaternary structure. (1989) (69)
Molecular paleoscience: systems biology from the past. (2007) (69)
Alternative Watson-Crick Synthetic Genetic Systems. (2016) (68)
When Did Life Likely Emerge on Earth in an RNA‐First Process? (2019) (67)
Experimental Evolution of a Facultative Thermophile from a Mesophilic Ancestor (2011) (67)
Pseudogenes in ribonuclease evolution: a source of new biomacromolecular function? (1996) (67)
Detecting compensatory covariation signals in protein evolution using reconstructed ancestral sequences. (2002) (64)
Nonionic Analogs of RNA with Dimethylene Sulfone Bridges (1996) (63)
Aptamers against Cells Overexpressing Glypican 3 from Expanded Genetic Systems Combined with Cell Engineering and Laboratory Evolution. (2016) (63)
Evaporite Borate-Containing Mineral Ensembles Make Phosphate Available and Regiospecifically Phosphorylate Ribonucleosides: Borate as a Multifaceted Problem Solver in Prebiotic Chemistry. (2016) (63)
Natural progression (2001) (62)
Bona fide prediction of aspects of protein conformation. Assigning interior and surface residues from patterns of variation and conservation in homologous protein sequences. (1994) (61)
Natural selection, protein engineering, and the last riboorganism: rational model building in biochemistry. (1987) (61)
Origin of dimeric structure in the ribonuclease superfamily. (1998) (60)
Challenging artificial genetic systems: thymidine analogs with 5-position sulfur functionality. (2002) (60)
Extracellular ‘communicator RNA’ (1988) (59)
The B12-dependent ribonucleotide reductase from the archaebacterium Thermoplasma acidophila: an evolutionary solution to the ribonucleotide reductase conundrum. (1997) (59)
Carbocyclic analogs of nucleosides via modified Mitsunobu reactions (1991) (58)
Synthetic Biology, Tinkering Biology, and Artificial Biology. What are We Learning? (2011) (58)
Functional inferences from reconstructed evolutionary biology involving rectified databases--an evolutionarily grounded approach to functional genomics. (2000) (57)
Expanding the genetic lexicon: incorporating non-standard amino acids into proteins by ribosome-based synthesis. (1994) (57)
Differential discrimination of DNA polymerase for variants of the non-standard nucleobase pair between xanthosine and 2,4-diaminopyrimidine, two components of an expanded genetic alphabet. (1996) (57)
Setting the stage: the history, chemistry, and geobiology behind RNA. (2012) (56)
Laboratory evolution of artificially expanded DNA gives redesignable aptamers that target the toxic form of anthrax protective antigen (2016) (54)
Expanding the genetic alphabet: non-epimerizing nucleoside with the pyDDA hydrogen-bonding pattern. (2003) (53)
Immunosuppressive activity of angiogenin in comparison with bovine seminal ribonuclease and pancreatic ribonuclease. (1995) (53)
Evaluation Measures of Multiple Sequence Alignments (2000) (52)
Multiplexed Genetic Analysis Using an Expanded Genetic Alphabet (2004) (52)
Theodore E. Woodward award. The evolution of obesity: insights from the mid-Miocene. (2010) (52)
A stereochemical imperative in dehydrogenases: new data and criteria for evaluating function-based theories in bioorganic chemistry (1985) (51)
Life after the synthetic cell (2010) (51)
Protein Structure Prediction (1996) (50)
DNA polymerases engineered by directed evolution to incorporate non-standard nucleotides (2014) (50)
Reverse transphosphorylation by ribonuclease A needs an intact p2-binding site. Point mutations at Lys-7 and Arg-10 alter the catalytic properties of the enzyme. (1994) (50)
Directed evolution of polymerases to accept nucleotides with nonstandard hydrogen bond patterns. (2013) (48)
Paradoxes in the Origin of Life (2014) (48)
Analysis of amino acid substitution during divergent evolution: the 400 by 400 dipeptide substitution matrix. (1994) (48)
A Strategy for Origins of Life Research (2015) (47)
Carbocyclic analogs of nucleosides. Part 2.. Synthesis of 2′,3′‐dideoxy‐5′‐homonucleoside analogs (1992) (47)
The return of pancreatic ribonucleases. (1989) (46)
Evolutionary, structural and biochemical evidence for a new interaction site of the leptin obesity protein. (2003) (46)
Fourier transform-ion cyclotron resonance mass spectrometric resolution, identification, and screening of non-covalent complexes of Hck Src homology 2 domain receptor and ligands from a 324-member peptide combinatorial library (2002) (45)
Building blocks for oligonucleotide analogs with dimethylene-sulfide, -sulfoxide, and -sulfone groups replacing phosphodiester linkages (1990) (43)
Interpreting the behavior of enzymes: purpose or pedigree? (1988) (42)
Nonstandard Hydrogen Bonding in Duplex Oligonucleotides. The Base Pair between an Acceptor-Donor-Donor Pyrimidine Analog and a Donor-Acceptor-Acceptor Purine Analog (1994) (42)
Predicted secondary structure for the Src homology 3 domain. (1993) (42)
Artificially Expanded Genetic Information Systems for New Aptamer Technologies (2018) (41)
Predicting de novo the folded structure of proteins (1992) (41)
An Aptamer-Nanotrain Assembled from 6-Letter DNA Delivers Doxorubicin Selectively to Liver Cancer Cells. (2019) (41)
pH-Independent Triple Helix Formation by an Oligonucleotide Containing a Pyrazine Donor-Donor-Acceptor Base (1995) (40)
Correct structure prediction? (1992) (40)
Mars Extant Life: What's Next? Conference Report (2020) (40)
High-throughput multiplexed xMAP Luminex array panel for detection of twenty two medically important mosquito-borne arboviruses based on innovations in synthetic biology. (2015) (40)
Transcription, reverse transcription, and analysis of RNA containing artificial genetic components. (2015) (40)
Dynamic transduction of energy and internal equilibria in enzymes: a reexamination of pyruvate kinase (1985) (40)
Post-genomic science: converting primary structure into physiological function. (1998) (39)
Quantitative analysis of a RNA-cleaving DNA catalyst obtained via in vitro selection. (2004) (39)
Assessing enzyme substrate specificity using combinatorial libraries and electrospray ionization-Fourier transform ion cyclotron resonance mass spectrometry. (1997) (38)
Bona Fide Predictions of Protein Secondary Structure Using Transparent Analyses of Multiple Sequence Alignments. (1997) (38)
The nitrogenase MoFe protein (1993) (38)
Redesigning nucleic acids (1998) (38)
Artificial genetic systems: self-avoiding DNA in PCR and multiplexed PCR. (2010) (38)
N2-Isobutyryl-O6-[2-(p-Nitrophenyl)Ethyl]Guanine: A New Building Block for the Efficient Synthesis of Carbocyclic Guanosine Analogs (1992) (38)
2-Hydroxymethylboronate as a reagent to detect carbohydrates: application to the analysis of the formose reaction. (2006) (37)
Artificial genetic systems: exploiting the "aromaticity" formalism to improve the tautomeric ratio for isoguanosine derivatives. (2004) (36)
Analysis of combinatorial libraries using electrospray Fourier transform ion cyclotron resonance mass spectrometry. (1996) (36)
Site‐directed mutagenesis of bovine pancreatic ribonuclease: Lysine‐41 and aspartate‐121 (1991) (35)
Crystal Structure of a Dimethylene Sulfone-Linked Ribodinucleotide Analog (1995) (35)
A Direct Route to 3‐(D‐Ribofuranosyl)pyridine Nucleosides (1991) (35)
Desorption/ionization on porous silicon mass spectrometry studies on pentose-borate complexes. (2005) (35)
An in vitro screening technique for DNA polymerases that can incorporate modified nucleotides. Pseudo-thymidine as a substrate for thermostable polymerases (1999) (35)
Origin of the catalytic activity of bovine seminal ribonuclease against double-stranded RNA. (1998) (34)
2 Reading the Palimpsest: Contemporary Biochemical Data and the RNA World (1993) (34)
Comment on “The Silicate-Mediated Formose Reaction: Bottom-Up Synthesis of Sugar Silicates” (2010) (34)
Design of a novel molecular beacon: modification of the stem with artificially genetic alphabet. (2008) (33)
Redesigning Genetics (2004) (32)
Recognition of Uncharged Polyamide-Linked Nucleic Acid Analogs by DNA Polymerases and Reverse Transcriptases (1997) (32)
The crystal structure of eEF1A refines the functional predictions of an evolutionary analysis of rate changes among elongation factors. (2002) (32)
Nucleoside alpha-thiotriphosphates, polymerases and the exonuclease III analysis of oligonucleotides containing phosphorothioate linkages (2007) (31)
Rearrangement of a geometrically restricted triepoxide to the first topologically nonplanar molecule: a reaction path elucidated by using oxygen isotope effects on carbon-13 chemical shifts (1981) (31)
Computational biochemistry research at ETH (1991) (31)
The last ribo-organism (1987) (30)
Oligodeoxyribonucleotide analogues with bridging dimethylene sulfide, sulfoxide, and sulfone groups. Toward a second-generation model of nucleic acid structure. (2002) (30)
Recognition of a non-standard base pair by thermostable DNA polymerases. (1998) (30)
Probing minor groove recognition contacts by DNA polymerases and reverse transcriptases using 3-deaza-2'-deoxyadenosine. (2004) (29)
Conversion strategy using an expanded genetic alphabet to assay nucleic acids. (2013) (29)
Synthesis and tautomeric equilibrium of 6-amino-5-benzyl-3-methylpyrazin-2-one. An acceptor-donor-donor nucleoside base analog (1993) (29)
A C-nucleotide base pair: methylpseudouridine-directed incorporation of formycin triphosphate into RNA catalyzed by T7 RNA polymerase. (1991) (28)
Evolutionary history of the uterine serpins. (2000) (28)
Recombinase‐Based Isothermal Amplification of Nucleic Acids with Self‐Avoiding Molecular Recognition Systems (SAMRS) (2014) (28)
2'-deoxycytidines carrying amino and thiol functionality: synthesis and incorporation by Vent (exo-) polymerase. (2004) (28)
A Biomimetic Biotechnological Process for Converting Starch to Fructose: Thermodynamic and Evolutionary Considerations in Applied Enzymology (1992) (28)
Synthesis of Oligonucleotides Containing 2′‐Deoxyisoguanosine and 2′‐Deoxy‐5‐methylisocytidine Using Phosphoramidite Chemistry (1998) (28)
Synthesis of RNA containing inosine: analysis of the sequence requirements for the 5' splice site of the Tetrahymena group I intron. (1991) (28)
Fluorescent charge-neutral analogue of xanthosine: synthesis of a 2'-deoxyribonucleoside bearing a 5-aza-7-deazaxanthine base. (2001) (27)
A predicted consensus structure for the N‐Terminal fragment of the heat shock protein HSP90 family (1997) (27)
Diphenylphosphinodithioic acid: A reagent for the conversion of nitriles to thioamides (1981) (27)
Evolution, language and analogy in functional genomics. (2001) (27)
"Skinny" and "Fat" DNA: Two New Double Helices. (2018) (27)
Predicting the conformation of proteins man versus machine (1993) (27)
Abiotic regioselective phosphorylation of adenosine with borate in formamide. (2015) (26)
Guanosine derivatives bearing an N2-3-imidazolepropionic acid (1994) (26)
Catalysts, Anticatalysts, and Receptors for Unactivated Phosphate Diesters in Water. (1999) (26)
Labeled Nucleoside Triphosphates with Reversibly Terminating Aminoalkoxyl Groups (2010) (26)
The planetary biology of cytochrome P450 aromatases (2004) (25)
From Phosphate to Bis(methylene) Sulfone: Non-Ionic Backbone Linkers in DNA (2002) (25)
Structural determinants of stereospecificity in yeast alcohol dehydrogenase. (1991) (25)
Free energy differences between enzyme bound states. (1987) (24)
Expression of bovine pancreatic ribonuclease A in Escherichia coli. (1987) (24)
6 Did the RNA World Exploit an Expanded Genetic Alphabet (1999) (24)
Probabilistic Ancestral Sequences and Multiple Alignments (1996) (24)
The stereoselectivity of alcohol dehydrogenases: A sterochemical imperative? (1982) (24)
Synthetic biology (2018) (24)
Prebiotic Chemistry that Could Not Not Have Happened (2019) (24)
Phylogenomic approaches to common problems encountered in the analysis of low copy repeats: The sulfotransferase 1A gene family example (2005) (23)
A hybrid of bovine pancreatic ribonuclease and human angiogenin: an external loop as a module controlling substrate specificity? (1991) (23)
Evolution and Structural Theory: The Frontier Between Chemistry and Biology (1990) (23)
Redesigning the Molecules of Life (1988) (23)
Helicase‐Dependent Isothermal Amplification of DNA and RNA by Using Self‐Avoiding Molecular Recognition Systems (2015) (23)
Confluence of Theory and Experiment Reveal the Catalytic Mechanism of the Varkud Satellite Ribozyme (2019) (22)
The evolution of seminal ribonuclease: pseudogene reactivation or multiple gene inactivation events? (2007) (22)
Recognition of an expanded genetic alphabet by type-II restriction endonucleases and their application to analyze polymerase fidelity (2011) (22)
Synthesis, Molecular Recognition, and Enzymology of Oligonucleotides Containing the Non‐standard Base Pair between 5‐Aza‐7‐deazaisoguanine and 6‐Amino‐3‐methylpyrazin‐2(1H)‐one, a Donor‐Acceptor‐Acceptor Purine Analog and an Acceptor‐Donor‐Donor Pyrimidine Analog (1996) (22)
Ribonucleosides for an Artificially Expanded Genetic Information System (2014) (21)
Synthesis of 2′‐Deoxyisoguanosine 5′‐Triphosphate and 2′‐Deoxy‐5‐methylisocytidine 5′‐Triphosphate (1999) (21)
The case for a Martian origin for Earth life (2015) (21)
The stereospecificities of seven dehydrogenases from Acholeplasma laidlawii. The simplest historical model that explains dehydrogenase stereospecificity. (1990) (20)
Detecting Darwinism from Molecules in the Enceladus Plumes, Jupiter's Moons, and Other Planetary Water Lagoons (2017) (20)
Engineering yeast alcohol dehydrogenase. Replacing Trp54 by Leu broadens substrate specificity. (1995) (20)
Adsorption of RNA on mineral surfaces and mineral precipitates (2017) (20)
A Direct Prebiotic Synthesis of Nicotinamide Nucleotide. (2018) (20)
Biophysics of Artificially Expanded Genetic Information Systems. Thermodynamics of DNA Duplexes Containing Matches and Mismatches Involving 2-Amino-3-nitropyridin-6-one (Z) and Imidazo[1,2-a]-1,3,5-triazin-4(8H)one (P). (2017) (20)
Libraries for Receptor-Assisted Combinatorial Synthesis (RACS). The Olefin Metathesis Reaction (1998) (20)
Evaluating predictions of secondary structure in proteins. (1994) (20)
The Donor-Acceptor-Acceptor Purine Analog: Transformation of 5-aza-7-deaza-1H-isoguanine (=4-aminoimidazo-[1,2-a]-1,3,5-triazin-2(1H)-one) to 2′-deoxy-5-aza-7-deaza-isoguanosine using purine nucleoside phosphorylase (1993) (19)
2'-deoxy-1-methylpseudocytidine, a stable analog of 2'-deoxy-5-methylisocytidine. (2009) (19)
A secondary structure prediction of the hemorrhagic metalloprotease family. (1993) (19)
Synthesis and Characterization of Non‐standard Nucleosides and Nucleotides Bearing the Acceptor‐Donor‐Donor Pyrimidine Analog 6‐Amino‐3‐methylpyrazin‐2(1H)‐one (1996) (19)
C-5 Modified Nucleosides: Direct Insertion of Alkynyl-Thio Functionality in Pyrimidines (2003) (18)
Autonomous assembly of synthetic oligonucleotides built from an expanded DNA alphabet. Total synthesis of a gene encoding kanamycin resistance (2014) (18)
The Natural History of Class I Primate Alcohol Dehydrogenases Includes Gene Duplication, Gene Loss, and Gene Conversion (2012) (18)
Interpretive proteomics--finding biological meaning in genome and proteome databases. (2003) (18)
Crystal Structures of Two Simple N-Substituted Dihydronicotinamides: Possible Implications for Stereoelectronic Arguments in Enzymology (1988) (18)
Catalysis: design versus selection. (1993) (18)
The past as the key to the present: Resurrection of ancient proteins from eosinophils (2002) (17)
Optical activity due to isotopic substitution. Vibrational circular dichroism and the absolute configurations of .alpha.-deuterated cyclohexanones (1981) (17)
Predicting protein crystal structures. (1994) (17)
The Adaptive Evolution Database (TAED) (2001) (17)
Synthetic Biology, Tinkering Biology, and Artificial Biology: A Perspective from Chemistry (2011) (16)
Predicted secondary and supersecondary structure for the serine–threonine‐specific protein phosphatase family (1995) (16)
Dynamic assembly of primers on nucleic acid templates (2006) (16)
Detecting respiratory viral RNA using expanded genetic alphabets and self-avoiding DNA (2015) (16)
Distorting Duplex DNA by Dimethylenesulfone Substitution: A New Class of “Transition State Analog” Inhibitors for Restriction Enzymes (1998) (15)
Stereochemical Profile of the Dehydrogenases of Drosophila melanogaster (1988) (15)
Predicting the conformation of proteins from sequences. Progress and future progress (1995) (15)
The stereospecificity of the ferrous-ion-dependent alcohol dehydrogenase from Zymomonas mobilis. (1989) (15)
Models and standards of proof in cross-disciplinary science: the case of arsenic DNA. (2013) (15)
Stereochemical imperative in enzymic decarboxylations. Stereochemical course of the decarboxylation catalyzed by acetoacetate decarboxylase (1984) (15)
Hydroxymethanesulfonate from Volcanic Sulfur Dioxide: A “Mineral” Reservoir for Formaldehyde and Other Simple Carbohydrates in Prebiotic Chemistry (2019) (15)
Synthesis as a Route to Knowledge (2013) (15)
A Crystal Structure of a Functional RNA Molecule Containing an Artificial Nucleobase Pair. (2015) (15)
Interferon‐γ activates the cleavage of double‐stranded RNA by bovine seminal ribonuclease (1990) (14)
Prebiotic glycosylation of uracil with electron-donating substituents. (2015) (14)
The stereospecificity of oxaloacetate decarboxylase: a stereochemical imperative? (1987) (14)
Synthesis and Characterization of Oligonucleotides Containing 2′‐Deoxyxanthosine Using Phosphoramidite Chemistry (2000) (14)
Tautomeric Equilibria of Nucleobases in the Hachimoji Expanded Genetic Alphabet. (2020) (14)
Affinity maturation of a portable Fab–RNA module for chaperone-assisted RNA crystallography (2018) (14)
An improved system for expressing pancreatic ribonuclease in Escherichia coli (1989) (13)
Engineered DNA Polymerases (2014) (13)
Structural changes to ribonuclease A and their effects on biological activity. (1999) (13)
A combinatorial distance-constraint approach to predicting protein tertiary models from known secondary structure. (1998) (13)
Recognition of 2'-deoxyisoguanosine triphosphate by HIV-1 reverse transcriptase and mammalian cellular DNA polymerases. (1998) (13)
Abiotic Synthesis of Nucleoside 5'-Triphosphates with Nickel Borate and Cyclic Trimetaphosphate (CTMP). (2021) (13)
Snapshots of an evolved DNA polymerase pre- and post-incorporation of an unnatural nucleotide (2018) (13)
Nearly Forty Years after Viking: Are We Ready for a New Life-Detection Mission? (2015) (13)
A prediction of the secondary structure of the pleckstrin homology domain (1994) (13)
Synthetic biology (2005) (12)
Synthesis and Properties of Oligodeoxynucleotide Analogs with Bis(methylene) Sulfone Bridges (2003) (12)
Expanding the Genetic Alphabet: Pyrazine Nucleosides That Support a Donor ? Donor ? Acceptor Hydrogen‐Bonding Pattern (2004) (12)
Multiplexed kit based on Luminex technology and achievements in synthetic biology discriminates Zika, chikungunya, and dengue viruses in mosquitoes (2019) (12)
Crystal structure of a hybrid between ribonuclease A and bovine seminal ribonuclease--the basic surface, at 2.0 A resolution. (1999) (12)
Self-Avoiding Molecular Recognition Systems (SAMRS). (2008) (12)
Catalytic Synthesis of Polyribonucleic Acid on Prebiotic Rock Glasses (2022) (12)
Chimera of Dimethylene Sulfone-, Methyl Sulfide-, and Methyl Sulfoxide-Linked Ribonucleotides and DNA. (1996) (12)
Synthesis and properties of 5-cyano-substituted nucleoside analog with a donor-donor-acceptor hydrogen-bonding pattern. (2012) (12)
Oligonucleotide analogs with dimethylenesulfide, -sulfoxide, and -sulfone groups replacing phosphodiester linkages. (1993) (12)
Biology from the bottom up (2008) (12)
Assays To Detect the Formation of Triphosphates of Unnatural Nucleotides: Application to Escherichia coli Nucleoside Diphosphate Kinase. (2016) (12)
Ligand Guided Selection (LIGS) with Artificially Expanded Genetic Information Systems against TCR-CD3ε. (2019) (12)
The challenge of synthetic biology. Synthetic Darwinism and the aperiodic crystal structure. (2018) (11)
1 Setting the Stage: The History, Chemistry, and Geobiology behind RNA (2006) (11)
Selective protection and deprotection procedures for thiol and hydroxyl groups (1993) (11)
Opal Adsorbs and Stabilizes RNA – A Hierarchy of Prebiotic Silica Minerals (2016) (11)
Aesthetics in synthesis and synthetic biology. (2012) (11)
Eliminating primer dimers and improving SNP detection using self-avoiding molecular recognition systems (2020) (11)
Ultra-rapid detection of SARS-CoV-2 in public workspace environments (2020) (11)
A review: synthesis of aryl C-glycosides via the heck coupling reaction. (2007) (11)
Predicting the conformation of proteins from sequences. Progress and future progress. (1994) (11)
A predicted consensus structure for the protein kinase C2 homology (C2H) domain, the repeating unit of synaptotagmin (1995) (11)
Polymerase Interactions with Wobble Mismatches in Synthetic Genetic Systems and Their Evolutionary Implications. (2016) (10)
"Progenote" or "protogenote"? (1990) (10)
Synthesis and Enzymology of 2'-Deoxy-7-deazaisoguanosine Triphosphate and Its Complement: A Second Generation Pair in an Artificially Expanded Genetic Information System. (2016) (10)
Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1. (2018) (10)
STEREOSPECIFICITY AND STEREOCHEMICAL INFIDELITY OF ACETOACETATE DECARBOXYLASE (AAD) (1981) (10)
The design of synthetic genes. (1988) (10)
Unusual Hydrogen Bonding Patterns and the Role of the Backbone in Nucleic Acid Information Transfer (2016) (9)
Combining enzymatic and chemical steps in the synthesis of biochemically valuable compounds: isotopically chiral methyl acetate (1983) (9)
Analogs for acetoacetate as an enzyme substrate. Stereochemical preferences (1981) (9)
A norovirus detection architecture based on isothermal amplification and expanded genetic systems. (2016) (9)
Return of the 'last ribo-organism' (1988) (9)
Structure prediction in a post-genomic environment: a secondary and tertiary structural model for the initiation factor 5A family. (1998) (9)
Incorporation of Multiple Sequential Pseudothymidines by DNA Polymerases and Their Impact on DNA Duplex Structure (2008) (9)
The phospho‐β‐galactosidase and synaptotagmin predictions (1995) (9)
The early days of paleogenetics: connecting molecules to the planet (2007) (9)
Application of DETECTER, an evolutionary genomic tool to analyze genetic variation, to the cystic fibrosis gene family (2006) (9)
Reconstructing the Evolution of Proteins (1988) (9)
A consensus prediction of the secondary structure for the 6‐phospho‐β‐D‐galactosidase superfamily (1995) (8)
Detection of chikungunya viral RNA in mosquito bodies on cationic (Q) paper based on innovations in synthetic biology. (2017) (8)
Planetary systems biology. (2005) (8)
Bona Fide Predictions of Protein Secondary Structure Using Transparent Analyses of Multiple Sequence Alignments (1998) (8)
A word in your protein (1993) (8)
Prebiotic plausibility and networks of paradox-resolving independent models (2018) (8)
Molybdenum(VI)-Catalyzed Rearrangement of Prebiotic Carbohydrates in Formamide, a Candidate Prebiotic Solvent. (2018) (8)
X-ray crystal structure of a dimethylene sulfone-bridged ribonucleotide dimer in a single-stranded state (1995) (8)
A Direct Synthesis of Nucleoside Analogs Homologated at the 3′‐ and 5′‐Positions (2003) (8)
A Convenient Synthesis of N,N′-dibenzyl-2,4-diaminopyrimidine-2′-deoxyribonucleoside and 1-Methyl-2′-Deoxypseudoisocytidine (2009) (8)
7 – Evolutionary Reconstructions in the Ribonuclease Family (1997) (8)
Body temperature and the specific heat of water (1986) (8)
Tautomeric equilibria of isoguanine and related purine analogs (2017) (7)
Synthetic biology with artificially expanded genetic information systems. From personalized medicine to extraterrestrial life. (2003) (7)
Synthesis and biodistribution of a short nonionic oligonucleotide analogue in mouse with a potential to mimic peptides. (1998) (7)
Mechanism of the reaction of diphenylphosphinodithioic acid with nitriles (1981) (7)
Preparation of an ecdysone immunogen for radioimmunoassay work. (1980) (7)
Structure and Biophysics for a Six Letter DNA Alphabet that Includes Imidazo[1,2-a]-1,3,5-triazine-2(8H)-4(3H)-dione (X) and 2,4-Diaminopyrimidine (K). (2017) (7)
Carbocyclic Analogs of Nucleosides. Part 4.† Preparation of enantiomerically pure analogs of purine nucleosides for the synthesis of sulfone-linked oligonucleotide analogs (1993) (7)
Standard and AEGIS nicking molecular beacons detect amplicons from the Middle East respiratory syndrome coronavirus (2016) (7)
Anomeric specificity of L-fucose dehydrogenase: a stereochemical imperative in aldopyranose dehydrogenases? (1987) (6)
Building better polymerases: Engineering the replication of expanded genetic alphabets (2020) (6)
OligArch: A software tool to allow artificially expanded genetic information systems (AEGIS) to guide the autonomous self-assembly of long DNA constructs from multiple DNA single strands (2014) (6)
Solubility of polyethers in hydrocarbons at low temperatures. A model for potential genetic backbones on warm titans. (2015) (6)
Interferon-gamma activates the cleavage of double-stranded RNA by bovine seminal ribonuclease. (1990) (6)
Expanded Genetic Alphabets: Managing Nucleotides That Lack Tautomeric, Protonated, or Deprotonated Versions Complementary to Natural Nucleotides. (2017) (6)
Biological phosphorylation of an Unnatural Base Pair (UBP) using a Drosophila melanogaster deoxynucleoside kinase (DmdNK) mutant (2017) (6)
A predicted consensus structure for the C terminus of the beta and gamma chains of fibrinogen (1997) (6)
Building Blocks for Oligonucleotide Analogues with Dimethylene Sulfide, Sulfoxide, and Sulfone Group Replacing Phosphodiester Linkages. (1991) (6)
Synthesis of a monocharged peptide nucleic acid (PNA) analog and its recognition as substrate by DNA polymerases. (1999) (6)
Stereospecificity in Enzymology: Its Place in Evolution (2007) (5)
Uniting Natural History with the Molecular Sciences. The Ultimate Multidisciplinarity. (2017) (5)
Deducing the Composition of Venus Cloud Particles with the Autofluorescence Nephelometer (AFN) (2022) (5)
Optimization of cationic (Q)-paper for detection of arboviruses in infected mosquitoes. (2018) (5)
A Direct Route to 3‐(D‐Ribofuranosyl)pyridine Nucleosides. (1991) (5)
The IAIMS--an essential infrastructure for increasing the competitiveness of health care practices. (1997) (5)
Reduction of 2-substituted 3-oxoglutarates mediated by Baker's yeast. Variation in enantioselectivity without corresponding variation in diastereoselectivity (1993) (5)
Next-generation DNA in pathogen detection, surveillance, and CLIA-waivable diagnostics (2015) (5)
Evolutionary, mechanistic, and predictive analyses of the hydroxymethyldihydropterin pyrophosphokinase family of proteins. (1999) (4)
Nucleoside analogs to manage sequence divergence in nucleic acid amplification and SNP detection (2018) (4)
The surprising pairing of 2-aminoimidazo[1,2-a][1,3,5]triazin-4-one, a component of an expanded DNA alphabet. (2019) (4)
New Insights into Boron Essentiality in Humans and Animals (2022) (4)
Fluorescent Charge-Neutral Analogue of Xanthosine: Synthesis of a 2′-Deoxyribonucleoside (I) Bearing a 5-Aza-7-deazaxanthine Base. (2001) (4)
Reconstructing Ancient Forms of Life (1998) (4)
Synthetic biology for improved personalized medicine. (2008) (4)
Developing new synthetic catalysts. How nature does it. (1996) (4)
Old Views of Ancient Events (1999) (4)
A Single Deoxynucleoside Kinase Variant from Drosophila melanogaster Synthesizes Monophosphates of Nucleosides That Are Components of an Expanded Genetic System. (2017) (4)
Designed enzymes: new peptides that fold in aqueous solution and catalyze reactions (1990) (4)
Rethinking nucleic acids from their origins to their applications (2023) (3)
RNA world [5] (1991) (3)
Four step synthesis of a 5′-deoxy-5′-iodomethylthymidine (1996) (3)
Q&A: Life, synthetic biology and risk (2010) (3)
Determination of the Absolute Configuration of Dimethyl (2S,3S)-2-Allyl-3-hydroxyglutarate: A Chiral Building Block for Preparing Branched-Chain Nucleoside Analogues (1993) (3)
Synthesis of an N-Alkyl Derivative of 2′-Deoxyisoguanosine. (1997) (3)
In vitro evolution of ribonucleases from expanded genetic alphabets (2022) (3)
Front Cover: When Did Life Likely Emerge on Earth in an RNA‐First Process? (ChemSystemsChem 2/2020) (2020) (3)
Mineral-Organic Interactions in Prebiotic Synthesis (2018) (3)
Uncertainty in ancient phylogenies (1995) (3)
SYNTHESIS OF AN N-ALKYL DERIVATIVE OF 2'-DEOXYISOGUANOSINE (1997) (3)
The resurrection of ribonucleases from mammals: from ecology to medicine (2007) (3)
Analysis of transitions at two-fold redundant sites in mammalian genomes. Transition redundant approach-to-equilibrium (TREx) distance metrics (2006) (3)
Simple one-pot synthesis of a 2'-tritium labeled C-deoxynucleoside. (1999) (3)
Electrochemical Reduction and Oxidation of Eight Unnatural 2'-Deoxynucleosides at a Pyrolytic Graphite Electrode. (2020) (3)
Unite Efforts and Conquer Mysteries of Artificial Genetics (2000) (3)
Comment on “A Bacterium That Can Grow by Using Arsenic Instead of Phosphorus” (2011) (2)
Visualizing "Alternative Isoinformational Engineered" DNA in A- and B-Forms at High Resolution. (2022) (2)
Chemistry. Redesigning genetics. (2004) (2)
Synthesis of Oligonucleotides Containing 2′‐Deoxyisoguanosine and 2′‐Deoxy‐5‐methylisocytidine Using Phosphoramidite Chemistry. (2010) (2)
Integrating protein structures and precomputed genealogies in the Magnum database: Examples with cellular retinoid binding proteins (2006) (2)
Libraries for Receptor-Assisted Combinatorial Synthesis (RACS). The Olefin Metathesis Reaction. (1998) (2)
Synthesis of Pyrophosphates for In Vitro Selection of Catalytic RNA Molecules (2008) (2)
Chemistry, life, and the search for aliens (2010) (2)
Protein structure prediction. (1996) (2)
Use of codon models in molecular dating and functional analysis (2012) (2)
Water: Constraining Biological Chemistry and the Origin of Life (2010) (2)
RNA world. (1991) (2)
Functionalization of nucleoside analogs: regiospecific conversion of 4"-hydroxyl groups to thioesters and deoxygenation of 3'-hydroxyl groups. (1998) (2)
The phospho-beta-galactosidase and synaptotagmin predictions. (1995) (1)
A Convenient Synthesis of N,N′-Dibenzyl-2,4-diaminopyrimidine-2′-deoxyribonucleoside and 1-Methyl-2′-deoxypseudoisocytidine. (2009) (1)
Crystal structures of deprotonated nucleobases from an expanded DNA alphabet. (2016) (1)
Nonionic Analogues of RNA with Dimethylene Sulfone Bridges. (1996) (1)
Reduction of 2-Substituted 3-Oxoglutarates Mediated by Bakers′ Yeast. Variation in Enantioselectivity without Corresponding Variation in Diastereoselectivity. (1993) (1)
A Direct Synthesis of Nucleoside Analogues Homologated at the 3′- and 5′-Positions. (2003) (1)
Chemical Guidance in the Search for Past and Extant Life on Mars (2020) (1)
Crystal structures of ‘ALternative Isoinformational ENgineered’ DNA in B-form (2023) (1)
Developing New Synthetic Catalysts. How Nature Does It (1996) (1)
Computational and Interpretive Genomics (2002) (1)
Agnostic Life Finder (ALF) for Large-Scale Screening of Martian Life During In Situ Refueling. (2022) (1)
APredicted Consensus Structure for the N-Terminal Fragment of the Heat Shock Protein HSP 90 Family (1997) (1)
The role of thrifty genes in the origin of alcoholism: A narrative review and hypothesis. (2021) (1)
Clay minerals as a formation catalyst and a stabilizer of ribose on the prebiotic EarthClay minerals as a formation catalyst and a stabilizer of ribose on the prebiotic Earth (2018) (1)
Evolutionary Guidance and the Engineering of Enzymes (1986) (0)
Thermophile from a Mesophilic Ancestor Experimental Evolution of a Facultative (2014) (0)
PCR ampliﬁcation of DNA containing non-standard base pairs by variants of reverse transcriptase from Human Immunodeﬁciency Virus-1 (0)
Transformation Rules Approximate Patterns and Queries 7.1 Complexity (1995) (0)
Synthesis, Molecular Recognition, and Enzymology of Oligonucleotides Containing the Non‐Standard Base Pair Between 5‐Aza‐7‐deazaisoguanine and 6‐Amino‐3‐methylpyrazin‐2(1H)‐one, a Donor‐Acceptor‐Acceptor Purine Analogue and an Acceptor‐Donor‐Donor Pyrimidine Analogue. (1997) (0)
Cover Picture: Evaporite Borate-Containing Mineral Ensembles Make Phosphate Available and Regiospecifically Phosphorylate Ribonucleosides: Borate as a Multifaceted Problem Solver in Prebiotic Chemistry (Angew. Chem. Int. Ed. 51/2016) (2016) (0)
From Genomes to Life to the Planet and the Cosmos: In Appreciation of Carl Sagan (2002) (0)
Book Review: Artificial Life II. A Proceedings Volume in the Santa Fe Institute Studies on the Sciences of Complexity. Edited by C. G. Langton, C. Taylor, J.D. Farmer, and S. Rasmussen (1993) (0)
A New Molecular Encoding System (1995) (0)
Selective Protection and Deprotection Procedures for Thiol and Hydroxyl Group. (1994) (0)
Design Automation Software for DNA-Based Nano-Sensor Architecture (2012) (0)
Inside Back Cover: A Crystal Structure of a Functional RNA Molecule Containing an Artificial Nucleobase Pair (Angew. Chem. Int. Ed. 34/2015) (2015) (0)
Efficient Regioselective Synthesis of Guanosine Analogs. (1993) (0)
Next-Generation Tools for Extracting Function from Genomic Sequence Data. A Working Synthetic Biology (2010) (0)
Novel Biopolymers Based on an Expanded Genetic Alphabet (1999) (0)
Functionalization of Nucleoside Analogues: Regiospecific Conversion of 4′′‐Hydroxyl Groups to Thioesters and Deoxygenation of 3′‐Hydroxyl Groups. (1998) (0)
Organic Minerals in the Origin of Life (2017) (0)
Oligonucleotide Analogues with Dimethylenesulfide, -sulfoxide, and - sulfone Groups Replacing Phosphodiester Linkages (1994) (0)
Frank Henry Westheimer. 15 January 1912—14 April 2007 (2018) (0)
Determination of the Absolute Configuration of Dimethyl (2S,3S)‐2‐ Allyl‐3‐hydroxyglutarate: A Chiral Building Block for Preparing Branched‐Chain Nucleoside Analogues. (1994) (0)
Thermodynamic Parameters and Design Considerations for Expanded Alphabet P-Z and G-Z Base Pairs in DNA (2021) (0)
Gene duplication can generate “whole gene” and “chimeric gene” paralogs. (2012) (0)
Synthesis and Properties of Oligodeoxynucleotide Analogues with Bis(methylene) Sulfone Bridges. (2003) (0)
Borate, Silicate, and Molybdate Control of Prebiotic Carbohydrate Synthesis (2010) (0)
DNA Duplex with Novel ZP Base Pair (2015) (0)
5'-monophosphate Z:P Guanine Riboswitch bound to hypoxanthine. (2015) (0)
Structure and Thermodynamics of Aegis Nucleotides P and Z in DNA (2015) (0)
The exhaustive genome comparison effort. A quarter-century later (2014) (0)
Prebiotic plausibility and networks of paradox-resolving independent models (2018) (0)
Joining Astrobiology to Medicine, Resurrecting Ancient Alcohol Metabolism (2010) (0)
Q U E S T I O N & A N S W E R Open Access (2010) (0)
Dating the pig duplication events (2011) (0)
Simple One-Pot Synthesis of a 2′-Tritium Labeled C-Deoxynucleoside. (2010) (0)
Alien life – not necessarily as we know it (2015) (0)
C-Glycoside DNA bases from an artificially expanded genetic information system reduce processivity in a SF2 helicase as revealed by nanopore tweezers (2022) (0)
Innenrücktitelbild: A Crystal Structure of a Functional RNA Molecule Containing an Artificial Nucleobase Pair (Angew. Chem. 34/2015) (2015) (0)
Structure Prediction with Combinatorial Distance Constraints (1997) (0)
Response : Computer Speed and Sequence Comparison (1992) (0)
C-5 Modified Nucleosides: Direct Insertion of Alkynyl-Thio Functionality in Pyrimidines. (2003) (0)
Synthesis as a Route to Knowledge (2013) (0)
Locked nucleic acid molecular beacons for intracellular mRNA monitoring (2006) (0)
Why Geology is the Key to Genomics. A Natural History Perspective on Function in Biology (2001) (0)
Other Genetic Alphabets (2018) (0)
Paradoxes in the Origin of Life (2014) (0)
Boron and the RNA world (2019) (0)
EVOLUTION-BASED GENOME ANALYSIS: AN ALTERNATIVE TO ANALYZE FOLDING AND FUNCTION IN PROTEINS (2004) (0)
Acknowledgment of Reviewers, 2019 (2019) (0)
In Search for Alternative Genetic Material (2019) (0)
Restriction enzymes cleave DNA immobilized on micron-sized diamond crystallites (2015) (0)
Supplementary material from "Frank Henry Westheimer. 15 January 1912 — 14 April 2007" (2018) (0)
Redesigning the Molecules of Life: Conference Papers of the International Symposium on Bioorganic Chemistry Interlaken, May 4-6, 1988 (1988) (0)
Carbocyclic Analogs of Nucleosides, e.g. (III), via Modified Mitsunobu Reactions. (1992) (0)
Fluorinated oil-surfactant mixtures with the density of water: Artificial cells for synthetic biology (2021) (0)
From Phosphate to Bis(methylene) Sulfone: Non-Ionic Backbone Linkers in DNA. (2003) (0)
EFFICIENT METHODOLOGY FOR THE SYNTHESIS OF 2,4-BENZODIAZEPIN-1- ONES, SULFONYLBENZOTRIAZOLES, SULFONAMIDES, ETHYLENE SULFONAMIDES, THIOCARBAMATES, DITHIOCARBAMATES AND THIOAMIDES By VALERIE RODRIGUEZ-GARCIA A DISSERTATION PRESENTED TO THE GRADUATE SCHOOL OF THE UNIVERSITY OF FLORIDA IN PARTIAL FULFI (2004) (0)
Frontiers of Astrobiology: Towards a Theory of Life (2012) (0)
Titelbild: Evaporite Borate-Containing Mineral Ensembles Make Phosphate Available and Regiospecifically Phosphorylate Ribonucleosides: Borate as a Multifaceted Problem Solver in Prebiotic Chemistry (Angew. Chem. 51/2016) (2016) (0)
Carbocyclic Analogues of Nucleosides. Part 4. Preparation of Enantiomerically Pure Analogues of Purine Nucleosides for the Synthesis of Sulfone‐Linked Oligonucleotide Analogues. (1993) (0)
The Chemical Details of How Life Could Have, Would Have, and Should Have Started on Mars (2019) (0)
The first self-replicating molecule and the origin of life (2014) (0)
Synthesis and Characterization of Non‐Standard Nucleosides and Nucleotides Bearing the Acceptor‐Donor‐Donor Pyrimidine Analogue 6‐ Amino‐3‐methylpyrazin‐2(1H)‐one. (1997) (0)
Structural properties of alien DNA, an alternative genetic system (2021) (0)
Assessing Readability of an 8-Letter Expanded Deoxyribonucleic Acid Alphabet with Nanopores. (2023) (0)
Four‐Step Synthesis of a 5′‐Deoxy‐5′‐iodomethylthymidine. (1996) (0)
Cladogram of the order Artiodactyla showing the extant families and some selected extinct ones (2011) (0)
Carbocyclic Analogues of Nucleosides. Part 2. Synthesis of 2′,3′- Dideoxy-5′-homonucleoside Analogues. (2010) (0)
volutionary , Mechanistic , and Predictive Analyses f the Hydroxymethyldihydropterin Pyrophosphokinase amily of Proteins (1998) (0)
Detection of Mosquito-borne Arboviruses by Twenty TwoMultiplexed xMAP Luminex Arrays Panel (2018) (0)
Building better polymerases: Engineering the replication of expanded genetic alphabets. (2020) (0)
Donor-Acceptor-Acceptor Purine Analogue: Transformation of 5-Aza-7- deaza-1H-isoguanine (= 4-Aminoimidazo(1,2-a)-1,3,5-triazin-2(1H)-one) to 2′-Deoxy-5-aza-7-deaza-isoguanosine Using Purine Nucleoside Phosphorylase. (1993) (0)

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