Steven Clarke

Q: What Schools Are Affiliated With Steven Clarke

Steven Clarke is affiliated with the following schools: University of California, Berkeley, Princeton University, University of Southern California, University of California, Los Angeles, Rockefeller University, Stanford University, Baylor College of Medicine, University of Washington, University of California, San Francisco, Harvard University

Steven Clarke's AcademicInfluence.com Rankings

Steven Clarke

Biology

#1732

World Rank

#2817

Historical Rank

#831

USA Rank

Biochemistry

#303

World Rank

#370

Historical Rank

#129

USA Rank

biology Degrees

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Biology

Steven Clarke's Degrees

Bachelors Biochemistry University of California, Berkeley
PhD Biochemistry Stanford University

Why Is Steven Clarke Influential?

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According to Wikipedia, Steven G. Clarke, an American biochemist, is a director of the UCLA Molecular Biology Institute, a professor of chemistry and biochemistry at UCLA biochemistry department. Clarke heads a laboratory at UCLA's department of chemistry and biochemistry. Clarke is famous for his work on molecular damage and discoveries of novel molecular repair mechanisms.

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Steven Clarke's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes (2008) (2360)
Protein arginine methylation in mammals: who, what, and why. (2009) (1533)
Deamidation, isomerization, and racemization at asparaginyl and aspartyl residues in peptides. Succinimide-linked reactions that contribute to protein degradation. (1987) (1151)
Human PAD4 Regulates Histone Arginine Methylation Levels via Demethylimination (2004) (993)
Protein isoprenylation and methylation at carboxyl-terminal cysteine residues. (1992) (812)
Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease. (1993) (723)
beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease. (1993) (668)
RNA and protein interactions modulated by protein arginine methylation. (1998) (527)
Widespread occurrence of three sequence motifs in diverse S-adenosylmethionine-dependent methyltransferases suggests a common structure for these enzymes. (1994) (473)
The Mammalian Immediate-early TIS21 Protein and the Leukemia-associated BTG1 Protein Interact with a Protein-arginine N-Methyltransferase* (1996) (473)
Succinimide formation from aspartyl and asparaginyl peptides as a model for the spontaneous degradation of proteins. (1989) (452)
PRMT1 Is the Predominant Type I Protein Arginine Methyltransferase in Mammalian Cells* (2000) (422)
PRMT5 (Janus Kinase-binding Protein 1) Catalyzes the Formation of Symmetric Dimethylarginine Residues in Proteins* (2001) (355)
The Novel Human Protein Arginine N-Methyltransferase PRMT6 Is a Nuclear Enzyme Displaying Unique Substrate Specificity* (2002) (337)
PRMT 3, a Type I Protein Arginine N-Methyltransferase That Differs from PRMT1 in Its Oligomerization, Subcellular Localization, Substrate Specificity, and Regulation* (1998) (316)
Propensity for spontaneous succinimide formation from aspartyl and asparaginyl residues in cellular proteins. (2009) (302)
Posttranslational modification of the Ha-ras oncogene protein: evidence for a third class of protein carboxyl methyltransferases. (1988) (291)
The size and detergent binding of membrane proteins. (1975) (288)
PRMT8, a New Membrane-bound Tissue-specific Member of the Protein Arginine Methyltransferase Family* (2005) (254)
Deficiency of a protein-repair enzyme results in the accumulation of altered proteins, retardation of growth, and fatal seizures in mice. (1997) (253)
Arginine Methylation Inhibits the Binding of Proline-rich Ligands to Src Homology 3, but Not WW, Domains* (2000) (251)
Protein carboxyl methyltransferases: two distinct classes of enzymes. (1985) (243)
Aging as war between chemical and biochemical processes: Protein methylation and the recognition of age-damaged proteins for repair (2003) (241)
S-Adenosylmethionine-dependent Methylation in Saccharomyces cerevisiae (1999) (234)
Uncovering the Human Methyltransferasome* (2010) (218)
The Saccharomyces cerevisiae STE14 gene encodes a methyltransferase that mediates C‐terminal methylation of a‐factor and RAS proteins. (1991) (218)
Exceptional seed longevity and robust growth: ancient Sacred Lotus from China (1995) (218)
Human Protein Arginine Methyltransferase 7 (PRMT7) Is a Type III Enzyme Forming ω-NG-Monomethylated Arginine Residues* (2012) (212)
In vivo differential prenylation of retinal cyclic GMP phosphodiesterase catalytic subunits. (1992) (205)
L-Ascorbate biosynthesis in higher plants: the role of VTC2. (2008) (203)
Protein methylation. (1993) (201)
Sequence of the D-aspartyl/L-isoaspartyl protein methyltransferase from human erythrocytes. Common sequence motifs for protein, DNA, RNA, and small molecule S-adenosylmethionine-dependent methyltransferases. (1989) (201)
The Predominant Protein-arginine Methyltransferase from Saccharomyces cerevisiae(*) (1996) (188)
PRMT7 Is a Member of the Protein Arginine Methyltransferase Family with a Distinct Substrate Specificity* (2004) (186)
Automated Identification of Putative Methyltransferases from Genomic Open Reading Frames*S (2003) (177)
2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling. (2015) (176)
Loss of the major Type I arginine methyltransferase PRMT1 causes substrate scavenging by other PRMTs (2013) (175)
Arabidopsis VTC2 Encodes a GDP-l-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants*♦ (2007) (174)
Membrane receptors for aspartate and serine in bacterial chemotaxis. (1979) (173)
Protein carboxyl methyltransferase facilitates conversion of atypical L-isoaspartyl peptides to normal L-aspartyl peptides. (1987) (168)
Conversion of isoaspartyl peptides to normal peptides: implications for the cellular repair of damaged proteins. (1987) (166)
Brain G protein gamma subunits contain an all-trans-geranylgeranylcysteine methyl ester at their carboxyl termini. (1990) (162)
PRMT9 is a Type II methyltransferase that methylates the splicing factor SAP145 (2015) (159)
Novel Methyltransferase for Modified Uridine Residues at the Wobble Position of tRNA (2003) (158)
Synthetic peptide substrates for the erythrocyte protein carboxyl methyltransferase. Detection of a new site of methylation at isomerized L-aspartyl residues. (1984) (158)
Protein methylation at the surface and buried deep: thinking outside the histone box. (2013) (150)
RpoS- and OxyR-independent induction of HPI catalase at stationary phase in Escherichia coli and identification of rpoS mutations in common laboratory strains (1997) (143)
Methylation at D-aspartyl residues in erythrocytes: possible step in the repair of aged membrane proteins. (1982) (143)
Mammalian Protein Arginine Methyltransferase 7 (PRMT7) Specifically Targets RXR Sites in Lysine- and Arginine-rich Regions* (2013) (142)
A major polypeptide component of rat liver mitochondria: carbamyl phosphate synthetase. (1976) (134)
Systems and Trans-System Level Analysis Identifies Conserved Iron Deficiency Responses in the Plant Lineage[W][OA] (2012) (125)
Role of ERAB/l-3-Hydroxyacyl-coenzyme A Dehydrogenase Type II Activity in Aβ-induced Cytotoxicity* (1999) (122)
Regulation of Protein Arginine Methyltransferase 8 (PRMT8) Activity by Its N-terminal Domain* (2007) (122)
DAL-1/4.1B tumor suppressor interacts with protein arginine N-methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo (2004) (121)
PRMT3 Is a Distinct Member of the Protein Arginine N-Methyltransferase Family (2000) (121)
Protein phosphatase 2A is reversibly modified by methyl esterification at its C-terminal leucine residue in bovine brain. (1994) (120)
Repair, refold, recycle: how bacteria can deal with spontaneous and environmental damage to proteins (1995) (118)
Identification of a C-terminal protein carboxyl methyltransferase in rat liver membranes utilizing a synthetic farnesyl cysteine-containing peptide substrate. (1990) (116)
Repair of spontaneously deamidated HPr phosphocarrier protein catalyzed by the L-isoaspartate-(D-aspartate) O-methyltransferase. (1994) (116)
Recognition of D-aspartyl residues in polypeptides by the erythrocyte L-isoaspartyl/D-aspartyl protein methyltransferase. Implications for the repair hypothesis. (1992) (115)
ACCELERATED RACEMIZATION OF ASPARTIC ACID AND ASPARAGINE RESIDUES VIA SUCCINIMIDE INTERMEDIATES : AN AB INITIO THEORETICAL EXPLORATION OF MECHANISM (1996) (112)
Structure of Thermotoga maritima stationary phase survival protein SurE: a novel acid phosphatase. (2001) (109)
Spontaneous degradation of polypeptides at aspartyl and asparaginyl residues: Effects of the solvent dielectric (1993) (105)
Identification and characterization of the methyl arginines in the fragile X mental retardation protein Fmrp. (2006) (104)
Neighboring side chain effects on asparaginyl and aspartyl degradation: an ab initio study of the relationship between peptide conformation and backbone NH acidity. (2001) (102)
Farnesyl cysteine C-terminal methyltransferase activity is dependent upon the STE14 gene product in Saccharomyces cerevisiae. (1990) (102)
Impact of Oxidative Stress on Ascorbate Biosynthesis in Chlamydomonas via Regulation of the VTC2 Gene Encoding a GDP-l-galactose Phosphorylase* (2012) (100)
The hydrophobic effect: Formation of micelles and biological membranes, 2nd edition (Tanford, Charles) (1981) (89)
N‐terminal methylation of proteins: Structure, function and specificity (1987) (88)
The l-Isoaspartyl Protein Repair Methyltransferase Enhances Survival of Aging Escherichia coli Subjected to Secondary Environmental Stresses (1998) (87)
A protein methyltransferase specific for altered aspartyl residues is important in Escherichia coli stationary-phase survival and heat-shock resistance. (1992) (86)
Identification of protein N-terminal methyltransferases in yeast and humans. (2010) (85)
Characterization of plant L-isoaspartyl methyltransferases that may be involved in seed survival: purification, cloning, and sequence analysis of the wheat germ enzyme. (1993) (83)
Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells. (2007) (82)
Membrane-binding domain of the small G protein G25K contains an S-(all-trans-geranylgeranyl)cysteine methyl ester at its carboxyl terminus. (1991) (81)
Limited Accumulation of Damaged Proteins inl-Isoaspartyl (d-Aspartyl)O-Methyltransferase-deficient Mice* (2001) (81)
Membrane protein carboxyl methylation increases with human erythrocyte age. Evidence for an increase in the number of methylatable sites. (1983) (80)
Age-dependent accumulation of protein residues which can be hydrolyzed to D-aspartic acid in human erythrocytes. (1986) (76)
Structural elements affecting the recognition of L-isoaspartyl residues by the L-isoaspartyl/D-aspartyl protein methyltransferase. Implications for the repair hypothesis. (1991) (76)
Protein Repair L-Isoaspartyl Methyltransferase in Plants (Phylogenetic Distribution and the Accumulation of Substrate Proteins in Aged Barley Seeds) (1997) (74)
Proteomic Identification of Novel Substrates of a Protein Isoaspartyl Methyltransferase Repair Enzyme* (2006) (72)
Hormonal and environmental responsiveness of a developmentally regulated protein repair L-isoaspartyl methyltransferase in wheat. (1994) (72)
Multiple Motif Scanning to Identify Methyltransferases from the Yeast Proteome* (2009) (71)
Purification, gene cloning, and sequence analysis of an L-isoaspartyl protein carboxyl methyltransferase from Escherichia coli. (1991) (70)
S-adenosyl-L-methionine synthetase from human erythrocytes: role in the regulation of cellular S-adenosylmethionine levels. (1983) (69)
RAS2 protein of Saccharomyces cerevisiae is methyl-esterified at its carboxyl terminus. (1989) (69)
APP/Aβ structural diversity and Alzheimer's disease pathogenesis (2017) (69)
A gene at 59 minutes on the Escherichia coli chromosome encodes a lipoprotein with unusual amino acid repeat sequences (1994) (68)
Characterization of the Drosophila protein arginine methyltransferases DART1 and DART4. (2004) (68)
Maturation of isoprenylated proteins in Saccharomyces cerevisiae. Multiple activities catalyze the cleavage of the three carboxyl-terminal amino acids from farnesylated substrates in vitro. (1992) (68)
A Novel 3-Methylhistidine Modification of Yeast Ribosomal Protein Rpl3 Is Dependent upon the YIL110W Methyltransferase* (2010) (67)
δ-N-Methylarginine Is a Novel Posttranslational Modification of Arginine Residues in Yeast Proteins* (1998) (66)
Phenotypic Analysis of Seizure-prone Mice Lacking l-Isoaspartate (d-Aspartate)O-Methyltransferase* (1999) (64)
Unique Features of Human Protein Arginine Methyltransferase 9 (PRMT9) and Its Substrate RNA Splicing Factor SF3B2* (2015) (63)
Methyl esterification of C-terminal leucine residues in cytosolic 36-kDa polypeptides of bovine brain. A novel eucaryotic protein carboxyl methylation reaction. (1993) (62)
The membrane binding domain of rod cGMP phosphodiesterase is posttranslationally modified by methyl esterification at a C-terminal cysteine. (1989) (62)
spoIID operon of Bacillus subtilis: cloning and sequence. (1986) (61)
Inhibition of protein carboxyl methylation by S-adenosyl-L-homocysteine in intact erythrocytes. Physiological consequences. (1984) (60)
A Second Protein l-Isoaspartyl Methyltransferase Gene in Arabidopsis Produces Two Transcripts Whose Products Are Sequestered in the Nucleus1[w] (2004) (60)
A Novel SET Domain Methyltransferase in Yeast (2006) (59)
Protein arginine methyltransferase 6 specifically methylates the nonhistone chromatin protein HMGA1a. (2005) (59)
A highly active protein repair enzyme from an extreme thermophile: the L-isoaspartyl methyltransferase from Thermotoga maritima. (1998) (58)
A Novel Automethylation Reaction in the Aspergillus nidulans LaeA Protein Generates S-Methylmethionine* (2013) (57)
Amyloid beta -peptide-binding alcohol dehydrogenase is a component of the cellular response to nutritional stress. (2000) (57)
Crystal structure of a protein repair methyltransferase from Pyrococcus furiosus with its L-isoaspartyl peptide substrate. (2001) (57)
A Second GDP-l-galactose Phosphorylase in Arabidopsis en Route to Vitamin C (2008) (56)
Methylation of membrane proteins in human erythrocytes. Identification and characterization of polypeptides methylated in lysed cells. (1981) (56)
Reversible methylation of cytoskeletal and membrane proteins in intact human erythrocytes. (1981) (56)
Characterization of a rat liver protein carboxyl methyltransferase involved in the maturation of proteins with the -CXXX C-terminal sequence motif. (1992) (56)
7 Postisoprenylation protein processing: CXXX (CaaX) endoproteases and isoprenylcysteine carboxyl methyltransferase (2001) (56)
Effect of adjacent histidine and cysteine residues on the spontaneous degradation of asparaginyl- and aspartyl-containing peptides. (2009) (54)
A Novel SET Domain Methyltransferase Modifies Ribosomal Protein Rpl23ab in Yeast* (2005) (54)
Identification of methylated proteins in the yeast small ribosomal subunit: a role for SPOUT methyltransferases in protein arginine methylation. (2012) (54)
Modification of eukaryotic signaling proteins by C-terminal methylation reactions. (1993) (53)
A Type III Protein Arginine Methyltransferase from the Protozoan Parasite Trypanosoma brucei* (2009) (53)
Does the chemical instability of aspartyl and asparaginyl residues in proteins contribute to erythrocyte aging? The role of protein carboxyl methylation reactions. (1988) (52)
Activation of the PI3K/Akt signal transduction pathway and increased levels of insulin receptor in protein repair‐deficient mice (2005) (51)
Two novel methyltransferases acting upon eukaryotic elongation factor 1A in Saccharomyces cerevisiae. (2010) (50)
Mechanistic studies on transcriptional coactivator protein arginine methyltransferase 1. (2011) (49)
Evidence for an S-farnesylcysteine methyl ester at the carboxyl terminus of the Saccharomyces cerevisiae RAS2 protein. (1990) (49)
Identification of Two SET Domain Proteins Required for Methylation of Lysine Residues in Yeast Ribosomal Protein Rpl42ab* (2008) (48)
Molecular phylogenetics of a protein repair methyltransferase. (1997) (48)
Purification of homologous protein carboxyl methyltransferase isozymes from human and bovine erythrocytes. (1988) (48)
Targeted gene disruption of the Caenorhabditis elegans L-isoaspartyl protein repair methyltransferase impairs survival of dauer stage nematodes. (1997) (47)
Distribution of an L-isoaspartyl protein methyltransferase in eubacteria (1992) (46)
Polymorphic forms of the protein L-isoaspartate (D-aspartate) O-methyltransferase involved in the repair of age-damaged proteins (1999) (46)
Spliceosome Sm proteins D1, D3, and B/B' are asymmetrically dimethylated at arginine residues in the nucleus. (2004) (46)
Bioinformatic Identification of Novel Methyltransferases. (2009) (45)
Epigenetic control via allosteric regulation of mammalian protein arginine methyltransferases (2017) (44)
A Novel Post-translational Modification of Yeast Elongation Factor 1A (2000) (44)
Protein L-isoaspartyl methyltransferase from the nematode Caenorhabditis elegans: genomic structure and substrate specificity. (1995) (44)
A new gene involved in stationary-phase survival located at 59 minutes on the Escherichia coli chromosome (1994) (44)
The graphite deposit at Borrowdale (UK): a catastrophic mineralizing event associated with Ordovician magmatism (2010) (43)
A mass spectrometric study on the in vitro methylation of HMGA1a and HMGA1b proteins by PRMTs: methylation specificity, the effect of binding to AT-rich duplex DNA, and the effect of C-terminal phosphorylation. (2007) (43)
RNase treatment of yeast and mammalian cell extracts affects in vitro substrate methylation by type I protein arginine N-methyltransferases. (1999) (43)
Chemical conversion of aspartyl peptides to isoaspartyl peptides. A method for generating new methyl-accepting substrates for the erythrocyte D-aspartyl/L-isoaspartyl protein methyltransferase. (1986) (43)
Substrate Specificity of Human Protein Arginine Methyltransferase 7 (PRMT7) (2014) (43)
Replacement of a labile aspartyl residue increases the stability of human epidermal growth factor. (1990) (42)
A glutamate/aspartate switch controls product specificity in a protein arginine methyltransferase (2016) (42)
Purification and Characterization of an Isoaspartyl Dipeptidase from Escherichia coli(*) (1995) (41)
Mutations in the Escherichia coli surE gene increase isoaspartyl accumulation in a strain lacking the pcm repair methyltransferase but suppress stress-survival phenotypes. (1998) (41)
Protein Arginine Methylation in Candida albicans: Role in Nuclear Transport (2007) (41)
A novel methyltransferase required for the formation of the hypermodified nucleoside wybutosine in eucaryotic tRNA. (2005) (41)
Lupus autoimmunity altered by cellular methylation metabolism (2013) (41)
Altered Levels of S-Adenosylmethionine and S-Adenosylhomocysteine in the Brains ofl-Isoaspartyl (d-Aspartyl)O-Methyltransferase-deficient Mice* (2002) (41)
Methylation of chicken fibroblast heat shock proteins at lysyl and arginyl residues. (1982) (40)
Enzymatic methylation of L-isoaspartyl residues derived from aspartyl residues in affinity-purified calmodulin. The role of conformational flexibility in spontaneous isoaspartyl formation. (1989) (40)
Methylation at specific altered aspartyl and asparaginyl residues in glucagon by the erythrocyte protein carboxyl methyltransferase. (1987) (39)
Chemo-enzymatic detection of protein isoaspartate using protein isoaspartate methyltransferase and hydrazine trapping. (2008) (39)
Expression and purification of a human recombinant methyltransferase that repairs damaged proteins. (1995) (38)
PRMT7 as a unique member of the protein arginine methyltransferase family: A review. (2019) (38)
Caenorhabditis elegans Battling Starvation Stress: Low Levels of Ethanol Prolong Lifespan in L1 Larvae (2012) (38)
Specific recognition of altered polypeptides by widely distributed methyltransferases. (1985) (38)
Deamidation and Isoaspartate Formation in Model Synthetic Peptides: The Effects of Sequence and Solution Environment (1995) (37)
Carboxyl methylation of cytosolic proteins in intact human erythrocytes. Identification of numerous methyl-accepting proteins including hemoglobin and carbonic anhydrase. (1984) (37)
Mammalian brain and erythrocyte carboxyl methyltransferases are similar enzymes that recognize both D-aspartyl and L-isoaspartyl residues in structurally altered protein substrates. (1984) (37)
Yeast Ribosomal/Cytochrome c SET Domain Methyltransferase Subfamily (2007) (37)
Methylation of erythrocyte membrane proteins at extracellular and intracellular D-aspartyl sites in vitro. Saturation of intracellular sites in vivo. (1983) (36)
A highly conserved 3-methylhistidine modification is absent in yeast actin. (1999) (36)
The γ subunit of brain G‐proteins is methyl esterified at a C‐terminal cysteine (1990) (36)
Specificity of endoproteinase Asp-N (Pseudomonas fragi): cleavage at glutamyl residues in two proteins. (1989) (36)
Substrates of the Arabidopsis thaliana Protein Isoaspartyl Methyltransferase 1 Identified Using Phage Display and Biopanning* (2010) (36)
TbPRMT6 Is a Type I Protein Arginine Methyltransferase That Contributes to Cytokinesis in Trypanosoma brucei (2010) (35)
An enzymatic activity in bovine brain that catalyzes the reversal of the C-terminal methyl esterification of protein phosphatase 2A. (1994) (35)
Histidine Methylation of Yeast Ribosomal Protein Rpl3p Is Required for Proper 60S Subunit Assembly (2014) (34)
D-aspartate content of erythrocyte membrane proteins is decreased in uremia: implications for the repair of damaged proteins. (1997) (34)
Metabolism of a synthetic L-isoaspartyl-containing hexapeptide in erythrocyte extracts. Enzymatic methyl esterification is followed by nonenzymatic succinimide formation. (1986) (34)
Alternative splicing of the human isoaspartyl protein carboxyl methyltransferase RNA leads to the generation of a C-terminal -RDEL sequence in isozyme II. (1992) (34)
Distinct patterns of expression but similar biochemical properties of protein L-isoaspartyl methyltransferase in higher plants. (2001) (34)
Use of lacZ gene fusions to determine the dependence pattern of the sporulation gene spoIID in spo mutants of Bacillus subtilis. (1986) (34)
Structure of amyloid-β (20-34) with Alzheimer’s-associated isomerization at Asp23 reveals a distinct protofilament interface (2019) (33)
Protein carboxyl methyltransferase and methyl acceptor proteins in aging and cataractous tissue of the human eye lens (1986) (33)
The protein carboxylmethyltransferase involved in Escherichia coli and Salmonella typhimurium chemotaxis. (1984) (32)
The Ribosomal L1 Protuberance in Yeast Is Methylated on a Lysine Residue Catalyzed by a Seven-β-strand Methyltransferase* (2011) (32)
A Novel GDP-d-glucose Phosphorylase Involved in Quality Control of the Nucleoside Diphosphate Sugar Pool in Caenorhabditis elegans and Mammals* (2011) (31)
Oxidative Modifications in Tissue Pathology and Autoimmune Disease. (2017) (31)
Calcium affects the spontaneous degradation of aspartyl/asparaginyl residues in calmodulin. (1989) (31)
Integrated proteomic analysis of major isoaspartyl-containing proteins in the urine of wild type and protein L-isoaspartate O-methyltransferase-deficient mice. (2013) (31)
Protein-arginine Methyltransferase 1 (PRMT1) Methylates Ash2L, a Shared Component of Mammalian Histone H3K4 Methyltransferase Complexes* (2011) (31)
Protein phosphatase methyltransferase 1 (Ppm1p) is the sole activity responsible for modification of the major forms of protein phosphatase 2A in yeast. (2001) (31)
Recognition of Age-damaged (R,S)-Adenosyl-L-methionine by Two Methyltransferases in the Yeast Saccharomyces cerevisiae* (2007) (30)
An Arabidopsis ATP-Dependent, DEAD-Box RNA Helicase Loses Activity upon IsoAsp Formation but Is Restored by PROTEIN ISOASPARTYL METHYLTRANSFERASE[C][W] (2013) (30)
Enzymatic methylation of 23-29-kDa bovine retinal rod outer segment membrane proteins. Evidence for methyl ester formation at carboxyl-terminal cysteinyl residues. (1989) (30)
Identification of aspartic acid as a site of methylation in human erythrocyte membrane proteins. (1980) (30)
Hsl7 is a substrate-specific type II protein arginine methyltransferase in yeast. (2008) (29)
Non-repair Pathways for Minimizing Protein Isoaspartyl Damage in the Yeast Saccharomyces cerevisiae* (2014) (29)
Arabidopsis Protein Repair L-Isoaspartyl Methyltransferases: Predominant Activities at Lethal Temperatures. (2006) (29)
Production of FAME biodiesel in E. coli by direct methylation with an insect enzyme (2016) (29)
A Novel Methyltransferase Catalyzes the Methyl Esterification of trans-Aconitate in Escherichia coli * (1999) (29)
16 Inhibition of mammalian protein methyltransferases by 5'-methylthioadenosine (MTA): A mechanism of action of dietary same? (2006) (29)
Crystal Structure of Human l-Isoaspartyl Methyltransferase* (2002) (28)
In vitro methylation of bacterial chemotaxis proteins: characterization of protein methyltransferase activity in crude extracts of Salmonella typhimurium. (1980) (28)
Yeast Hsl7 (histone synthetic lethal 7) catalyses the in vitro formation of omega-N(G)-monomethylarginine in calf thymus histone H2A. (2006) (28)
Rmt1 catalyzes zinc-finger independent arginine methylation of ribosomal protein Rps2 in Saccharomyces cerevisiae. (2010) (27)
Improved rotorod performance and hyperactivity in mice deficient in a protein repair methyltransferase (2004) (27)
Structure and function of an archaeal homolog of survival protein E (SurEalpha): an acid phosphatase with purine nucleotide specificity. (2003) (27)
Protein Arginine Methyltransferase Product Specificity Is Mediated by Distinct Active-site Architectures* (2016) (27)
Evolutionarily Divergent Type II Protein Arginine Methyltransferase in Trypanosoma brucei (2007) (27)
Increased cell proliferation and granule cell number in the dentate gyrus of protein repair‐deficient mice (2005) (26)
Two major isozymes of the protein D-aspartyl/L-isoaspartyl methyltransferase from human erythrocytes. (1988) (26)
Do eukaryotic carboxyl methyltransferase regulate protein function (1983) (26)
The L-isoaspartyl-O-methyltransferase in Caenorhabditis elegans larval longevity and autophagy. (2007) (26)
Metabolism of S-adenosyl-L-methionine in intact human erythrocytes. (1986) (25)
Fighting cancer by disrupting C-terminal methylation of signaling proteins. (2004) (25)
A distinctly regulated protein repair L-isoaspartylmethyltransferase from Arabidopsis thaliana (1996) (25)
Approaches to measuring the activities of protein arginine N-methyltransferases. (2010) (25)
The polypeptides of rat liver mitochondria: identification of a 36,000 dalton polypeptide as the subunit of ornithine transcarbamylase. (1976) (24)
Defective responses to oxidative stress in protein l-isoaspartyl repair-deficient Caenorhabditis elegans (2009) (24)
Distinct reactions catalyzed by bacterial and yeast trans-aconitate methyltransferases. (2001) (24)
Intracellular Protein Modification Associated with Altered T Cell Functions in Autoimmunity1 (2006) (24)
Methylation of yeast ribosomal protein Rpl3 promotes translational elongation fidelity (2016) (23)
Translational Roles of Elongation Factor 2 Protein Lysine Methylation* (2014) (23)
Homocysteine Methyltransferases Mht1 and Sam4 Prevent the Accumulation of Age-damaged (R,S)-AdoMet in the Yeast Saccharomyces cerevisiae* (2010) (23)
Multiple sites of methyl esterification of calmodulin in intact human erythrocytes. (1990) (23)
Spontaneous degradation and enzymatic repair of aspartyl and asparaginyl residues in aging red cell proteins analyzed by computer simulation. (1991) (23)
Protein carboxyl methyltransferase from cow eye lens. (1983) (22)
Expression, purification, and characterization of the protein repair l-isoaspartyl methyltransferase from Arabidopsis thaliana. (2000) (22)
Protein carboxyl methylation in Saccharomyces cerevisiae: evidence for STE14-dependent and STE14-independent pathways. (1994) (22)
Purification and characterization of a novel metalloendopeptidase from Saccharomyces cerevisiae. (1993) (22)
Regulation of stage II of sporulation in Bacillus subtilis. (1987) (22)
A Systems Biology Approach Reveals the Role of a Novel Methyltransferase in Response to Chemical Stress and Lipid Homeostasis (2011) (22)
The interaction of Triton X-100 with soluble proteins: possible implications for the transport of proteins across membranes. (1977) (22)
Ethanol-induced differential gene expression and acetyl-CoA metabolism in a longevity model of the nematode Caenorhabditis elegans (2015) (21)
A new technique (COMSPARI) to facilitate the identification of minor compounds in complex mixtures by GC/MS and LC/MS: tools for the visualization of matched datasets (2004) (21)
Chemical modifications of deposited amyloid-beta peptides. (1999) (21)
Protein Repair Methyltransferase from the Hyperthermophilic Archaeon Pyrococcus furiosus (2002) (20)
Identification of the gene and characterization of the activity of the trans-aconitate methyltransferase from Saccharomyces cerevisiae. (2001) (20)
Do damaged proteins accumulate in Caenorhabditis elegans L-isoaspartate methyltransferase (pcm-1) deletion mutants? (1999) (20)
The Major Protein Arginine Methyltransferase in Trypanosoma brucei Functions as an Enzyme-Prozyme Complex* (2016) (20)
PRMT 9 is a Type II methyltransferase that methylates the splicing factor SAP 145 (2015) (19)
Structure of the human gene encoding the protein repair L-isoaspartyl (D-aspartyl) O-methyltransferase. (1996) (19)
The Interplay between Protein L-Isoaspartyl Methyltransferase Activity and Insulin-Like Signaling to Extend Lifespan in Caenorhabditis elegans (2011) (19)
The methylator meets the terminator (2002) (19)
HIV protease inhibitors and nuclear lamin processing: Getting the right bells and whistles (2007) (19)
Analysis of prenylated carboxyl-terminal cysteine methyl esters in proteins (1990) (19)
Analysis of erythrocyte protein methyl esters by two-dimensional gel electrophoresis under acidic separating conditions. (1985) (18)
Thermal-Stable Proteins of Fruit of Long-Living Sacred Lotus Nelumbo nucifera Gaertn var. China Antique (2013) (18)
Methylation of calmodulin at carboxylic acid residues in erythrocytes. A non-regulatory covalent modification? (1986) (18)
Human erythrocyte protein L-isoaspartyl methyltransferase: heritability of basal activity and genetic polymorphism for thermal stability. (1997) (17)
Perspectives on the biological function and enzymology of protein carboxyl methylation reactions in eucaryotic and procaryotic cells. (1988) (17)
A new type of protein lysine methyltransferase trimethylates Lys-79 of elongation factor 1A. (2014) (17)
Intracellular protein modification associated with altered T cell functions in autoimmunity (2006) (17)
Amino acid polymorphisms of the human L-isoaspartyl/D-aspartyl methyltransferase involved in protein repair. (1994) (17)
Enzymatic methylation of band 3 anion transporter in intact human erythrocytes. (1987) (17)
A PROTEIN CARBOXYL METHYLTRANSFERASE THAT RECOGNIZES AGE-DAMAGED PEPTIDES AND PROTEINS AND PARTICIPATES IN THEIR REPAIR (1999) (16)
Computational methods to identify novel methyltransferases (2009) (16)
Ornithine transcarbamylase from Neurospora crassa: purification and properties. (1985) (15)
The ribosome: A hot spot for the identification of new types of protein methyltransferases (2018) (15)
Determining the Mitochondrial Methyl Proteome in Saccharomyces cerevisiae using Heavy Methyl SILAC. (2016) (14)
Distinct C-terminal sequences of isozymes I and II of the human erythrocyte L-isoaspartyl/D-aspartyl protein methyltransferase. (1991) (14)
The L-isoaspartyl/D-aspartyl protein methyltransferase gene (PCMT1) maps to human chromosome 6q22.3-6q24 and the syntenic region of mouse chromosome 10. (1992) (14)
Direct renaturation of the dodecyl sulfate complexes of proteins with Triton X-100. (1981) (14)
Circumventing Embryonic Lethality with Lcmt1 Deficiency: Generation of Hypomorphic Lcmt1 Mice with Reduced Protein Phosphatase 2A Methyltransferase Expression and Defects in Insulin Signaling (2013) (13)
Wortmannin Reduces Insulin Signaling and Death in Seizure-Prone Pcmt1−/− Mice (2012) (13)
A new type of protein methylation activated by tyrphostin A25 and vanadate (2004) (13)
Human erythrocyte D-aspartyl/L-isoaspartyl methyltransferases: enzymes that recognize age-damaged proteins. (1991) (13)
Protein-repair and hormone-signaling pathways specify dauer and adult longevity and dauer development in Caenorhabditis elegans. (2008) (13)
Ribosomal DNA Restriction Fragment Analysis of Some Closely Related Streptomyces Species (1993) (13)
S-adenosylmethionine synthetase in cultured normal and oncogenically-transformed human and rat cells. (1983) (12)
Autophagy and Insulin/TOR Signaling in Caenorhabditis elegans pcm-1 Protein Repair Mutants (2007) (12)
3-Isopropylmalate is the major endogenous substrate of the Saccharomyces cerevisiae trans-aconitate methyltransferase. (2004) (12)
Secreted 3-isopropylmalate methyl ester signals invasive growth during amino acid starvation in Saccharomyces cerevisiae. (2008) (12)
Mechanism of cleavage at Asn 148 during the maturation of jack bean concanavalin A. (1993) (12)
The invertebrate Caenorhabditis elegans biosynthesizes ascorbate (2015) (11)
Caenorhabditis elegans PRMT-7 and PRMT-9 Are Evolutionarily Conserved Protein Arginine Methyltransferases with Distinct Substrate Specificities. (2017) (11)
Brain proteomics supports the role of glutamate metabolism and suggests other metabolic alterations in protein l-isoaspartyl methyltransferase (PIMT)-knockout mice. (2013) (11)
Rapid degradation of D- and L-succinimide-containing peptides by a post-proline endopeptidase from human erythrocytes. (1987) (11)
Identification of isoaspartyl-containing sequences in peptides and proteins that are usually poor substrates for the class II protein carboxyl methyltransferase. (1990) (11)
Size and shape of membrane protein-detergent complexes: hydrodynamic studies. (1989) (11)
Protein asymmetry in the inner membrane of rat liver mitochondria. (1976) (11)
The fidelity of protein synthesis: can mischarging by aspartyl-tRNA(Asp) synthetase lead to the formation of isoaspartyl residues in proteins? (1990) (10)
Extent and Instability of Trimethylation of Histone H3 Lysine Increases With Degree of Malignancy and Methionine Addiction (2021) (10)
The l-isoaspartate modification within protein fragments in the aging lens can promote protein aggregation (2019) (10)
Systems and Trans-System Level Analysis Identi fi es Conserved Iron (2013) (9)
[31] Isolation of d-aspartic acid β-methyl ester from erythrocyte carboxyl methylated proteins (1984) (9)
Protein methylation and translation: Role of lysine modification on the function of yeast elongation factor 1 alpha (2018) (9)
10 Genetic approaches to understanding the physiologic importance of the carboxyl methylation of isoprenylated proteins. (2006) (9)
Protein Methylation at Abnormal Aspartyl Residues (1986) (8)
Adenine ribo- and deoxyribonucleotide metabolism in human erythrocytes, B- and T-lymphocyte cell lines, and monocyte-macrophages. (1985) (8)
Demethylation of protein carboxyl methyl esters: a nonenzymatic process in human erythrocytes? (1985) (8)
A novel small molecule methyltransferase is important for virulence in Candida albicans. (2013) (8)
Protein aging Extracellular amyloid formation and intracellular repair. (1994) (8)
Dissociation of an early event in sporulation from chromosome replication in Bacillus subtilis. (1980) (8)
Yeast, plants, worms, and flies use a methyltransferase to metabolize age-damaged (R,S)-AdoMet, but what do mammals do? (2010) (8)
Deuteration protects asparagine residues against racemization (2016) (8)
The protein l-isoaspartyl-O-methyltransferase functions in the Caenorhabditis elegans stress response (2008) (8)
Can Elevated Plasma Homocysteine Levels Result in the Inhibition of Intracellular Methyltransferases (2002) (7)
Farnesyl cysteine C-terminal methyltransferase activity is dependent upon the STE14 gene product in Saccharomyces cerevisiae (1990) (7)
Yeast Hsl 7 ( histone synthetic lethal 7 ) catalyses the in vitro formation of ω-NG-monomethylarginine in calf thymus histone H 2 A (2006) (6)
Membrane protein carboxyl methylation does not appear to be involved in the response of erythrocytes to cytoskeletal stress. (1984) (6)
Racemized and Isomerized Proteins in Aging Rat Teeth and Eye Lens. (2016) (6)
Diet-dependent survival of protein repair-deficient mice. (2005) (6)
Rmt 1 catalyzes zinc-finger independent arginine methylation of ribosomal protein Rps 2 in Saccharomyces cerevisiae (2010) (6)
The gamma subunit of brain G-proteins is methyl esterified at a C-terminal cysteine. (1990) (5)
Rapid mapping of genomic P1 clones: the mouse L-isoaspartyl/D-aspartyl methyltransferase gene. (1996) (5)
Carboxyl methylation of human erythrocyte band 3 in intact cells. Relation to anion transport activity. (1986) (5)
Membrane-binding domain of the small G protein G 25 K contains an S-( all-trans-geranylgeranyl ) cysteine methyl ester at its carboxyl terminus ( prenylation / carboxyl methylation / signal transduction ) (5)
S-Adenosylmethionine-dependent Protein Methylation in Mammalian Cytosol via Tyrphostin Modification by Catechol-O-methyltransferase* (2007) (4)
Genetic screening reveals phospholipid metabolism as a key regulator of the biosynthesis of the redox-active lipid coenzyme Q (2021) (4)
Ribosomal protein methyltransferases in the yeast Saccharomyces cerevisiae: Roles in ribosome biogenesis and translation. (2016) (4)
Author ' s personal copy Two novel methyltransferases acting upon eukaryotic elongation factor 1 A in Saccharomyces cerevisiae (2010) (3)
Uncovering the Human Methyltransferasome * □ S (2010) (3)
l-galactose Phosphorylase Gene Encoding a VTC 2 Regulation of the via Chlamydomonas Biosynthesis in Impact of Oxidative Stress on Ascorbate Plant Biology : (2012) (3)
The linkage of methionine addiction, overmethylation of histone H3 lysines and malignancy demonstrated when cancer cells revert to methionine-independence (2020) (3)
N-phthaloylation of chloro- and hydroxy-2-amino-acids (1973) (3)
Regulation of Stage I1 of Sporulation in Bacillus subtilis (1987) (3)
Isoaspartyl Dipeptidase (IadA) (2013) (3)
Human ARMT1 structure and substrate specificity indicates that it is a DUF89 family damage-control phosphatase. (2020) (2)
Expression , Purification , and Characterization of the Protein Repair L-Isoaspartyl Methyltransferase rom Arabidopsis thaliana (2000) (2)
The effect of protein modification reagents on the chemotactic response in Salmonella typhimurium. (1979) (2)
A novel SET domain methyltransferase in yeast: Rkm2-dependent trimethylation of ribosomal protein L12ab at the N terminus. VOLUME 281 (2006) PAGES 35835-35845 (2008) (2)
Characterization of the activity and biological function of human protein arginine methyltransferase 9 (555.6) (2014) (2)
Assignment1 of the protein L-isoaspartate (D-aspartate) O-methyltransferase gene (PCMT1) to human chromosome bands 6q24→q25 with radiation hybrid mapping (1999) (2)
Histidine methylation of yeast ribosomal protein Rpl 3 p is 1 required for proper 60 S subunit assembly 2 3 (2014) (2)
Human Protein-l-isoaspartate O-Methyltransferase Domain-Containing Protein 1 (PCMTD1) Associates with Cullin-RING Ligase Proteins. (2022) (1)
l-Isoaspartyl Methyltransferase Deficiency in Zebrafish Leads to Impaired Calcium Signaling in the Brain (2021) (1)
Carbonyl Post-Translational Modification Associated with Early Onset Type 1 Diabetes Autoimmunity (2021) (1)
ErratumErratum to “Structure and Function of an Archaeal Homolog of Survival Protein E (SurEα): An Acid Phosphatase with Purine Nucleotide Specificity”: J. Mol. Biol. (2003) 326, 1559–1575 (2003) (1)
AI-13 Protein modifications that trigger T cell autoimmunity (2016) (1)
Mammalian protein arginine methyltransferase 7 (PRMT7) specifically targets R‐X‐R sites in lysine and arginine‐rich regions (555.1) (2014) (1)
IadA β-aspartyl dipeptidase (2004) (1)
The stereospecificity of protein kinases. (1987) (1)
Homocysteine Methyltransferases Mht 1 and Sam 4 Prevent the Accumulation of Age-damaged ( R , S )-AdoMet in the Yeast Saccharomyces cerevisiae * (2010) (1)
Methylation of Erythrocyte Membrane Intracellular D-Aspartyl Sites in Vitro (2001) (0)
Abstract 1783: Probing protein arginine methyltransferase (PRMT) activity in mammalian cell lysates (2023) (0)
Amyloid-Beta (20-34) wild type (2019) (0)
Rmt1 catalyzes zinc-finger independent arginine methylation of the small ribosomal protein Rps2 in Saccharomyces cerevisiae (2010) (0)
Crystal Structure of L-isoaspartyl (D-aspartyl) O-methyltransferase with S-ADENOSYL-L-HOMOCYSTEINE (2001) (0)
Abstract 2648: Can we predict coenzyme Q deficiency in patients? The case of COQ5, a C-methyltransferase in coenzyme Q biosynthesis (2023) (0)
The 2.0-Angstrom resolution crystal structure of a survival protein E (SurE) homolog from Pyrobaculum aerophilum (2003) (0)
Wortmannin Reduces Insulin Signaling and Death in Seizure-Prone Pcmt 1 2 / 2 Mice (2012) (0)
ole of Methionine Adenosyltransferase 2 A and S-adenosylmethionine in itogen-Induced Growth of Human Colon Cancer Cells (2007) (0)
Amyloid-Beta (20-34) with L-isoaspartate 23 (2019) (0)
Crystal Structure of L-isoaspartyl (D-aspartyl) O-methyltransferase with S-adenosylmethionine (2001) (0)
Lipoprotein with Unusual Amino Acid Repeat Sequences (0)
An acidic loop within the human soluble CD23 protein may direct the interaction between sCD23 and the αXβ2 integrin. (2019) (0)
Purification and Characterization of a Novel Metalloendopeptidase from Saccharomyces cerevisiaet (2001) (0)
Accelerated Racemization of Aspartic Acid and Asparagine Residues via Succinimide Intermediates: An ab initio Theoretical Exploration of Mechanism. (1997) (0)
Isolation of D-aspartic acid beta-methyl ester from erythrocyte carboxyl methylated proteins. (1984) (0)
Ellagic Acid and Urolithin A Improve Insulin Sensitivity in Diet-Induced Insulin Resistant Mice and Reduce Detrimental Effects of Palmitate Administration in Differentiated C2C12 Myotubes (2018) (0)
Visualization of the core of a modified Amyloid-β polymorph with MicroED (2019) (0)
Thermal-Stable Proteins of Fruit of Long-Living Sacred Lotus Nelumbo nucifera Gaertn var. China Antique (2013) (0)
A New Gene Involved in Stationary-Phase Survival Located at 59 Minutes on the Escherichia coli Chromosome (1996) (0)
Correction: The Interplay between Protein L-Isoaspartyl Methyltransferase Activity and Insulin-Like Signaling to Extend Lifespan in Caenorhabditis elegans (2013) (0)
The methylator meets the tel (2016) (0)
Enzymatic ethyla at ion of 23-29-kDa Bovine Retinal Rod Outer Segment Membrane Proteins (2001) (0)
The Impact of Various Genetic Manipulations on the Phenetic Identification of Streptomyces Species (1995) (0)
A b structural diversity and Alzheimer ' s disease pathogenesis (2017) (0)
Enzymatic methylation at specific altered aspartyl and asparaginyl residues in glucagon (1986) (0)
Chemical modification of the 6'-amino cyclopropyl of abacavir eliminates HLA-B*57:01-restricted CD8+ T-cell activation without loss of antiviral activity (2014) (0)
2-Hydroxyglutarate Inhibit s ATP Synthase andmTOR Signaling Graphical (2015) (0)
Crystal Structure of L-isoaspartyl (D-aspartyl) O-methyltransferase with adenosine (2001) (0)
Saccharomyces cerevisiae Protein Isoaspartyl Damage in the Yeast Non-Repair Pathways for Minimizing Protein Synthesis and Degradation : (2014) (0)
Characterization of the Activity and Biological Function of Human Protein Arginine Methyltransferase 9 (PRMT9) (2015) (0)
Design, synthesis and biological evaluation of new selective arginine methyltransferases (PRMTs) Inhibitors (2018) (0)
Deuteration protects asparagine residues against racemization (2016) (0)
Isolation of a Housefly Head Protein Fraction that Exhibits High Affinity Binding of Cholinergic Ligands (2018) (0)
Chapter 12 Why are proteins methylated (1995) (0)
Regulation of Stage I 1 of Sporulation in Bacillus subtilis (2008) (0)
A Glycine-Dependent Riboswitch That Uses Cooperative Binding to Control Gene Expression (0)
MULTIPLE ACTIVITIES CATALYZE THE CLEAVAGE OF THE THREE CARBOXYL-TERMINAL AMINO ACIDS FROM FARNESYLATED SUBSTRATES (2001) (0)
A Combined Small Molecule and shRNA High-content Screen of Chromatin Modifiers Identifies an Acetyl-lysine Binding Protein as a Suppressor of the DNA Damage Response to Ionizing Radiation (2009) (0)
Impact of Oxidative Stress on Ascorbate Biosynthesis in Chlamydomonas via Regulation of the VTC2 Gene Encoding a (2012) (0)
Abstract 1754: Can Aged-Damaged Proteins Be Targeted for Degradation? Early Insights in the Structural and Molecular Characterization of Human Protein-L-Isoaspartate O-Methyltransferase Domain-Containing Protein 1 (PCMTD1) (2023) (0)
Isoaspartyl modification of ZAP70 signaling molecule alters T cell responses (555.9) (2014) (0)
Crystal Structure of L-isoaspartyl (D-aspartyl) O-methyltransferase with adenosine & VYP(ISP)HA substrate (2001) (0)

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