Steven F. Maier

Steven F. Maier's AcademicInfluence.com Rankings

Steven F. Maier

Biology

#2842

World Rank

#4444

Historical Rank

Neuroscience

#251

World Rank

#265

Historical Rank

biology Degrees

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Biology

Steven F. Maier's Degrees

PhD Neuroscience University of California, Berkeley
Doctorate Medicine Stanford University

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Steven F. Maier's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Learned helplessness: Theory and evidence. (1976) (2194)
Failure to escape traumatic shock. (1967) (1753)
Cytokines for psychologists: implications of bidirectional immune-to-brain communication for understanding behavior, mood, and cognition. (1998) (1176)
Glial activation: a driving force for pathological pain (2001) (1050)
Learned Helplessness: A Theory for the Age of Personal Control (1993) (949)
Medial prefrontal cortex determines how stressor controllability affects behavior and dorsal raphe nucleus (2005) (886)
Beyond neurons: evidence that immune and glial cells contribute to pathological pain states. (2002) (712)
Pathological pain and the neuroimmune interface (2014) (673)
Immune activation: the role of pro-inflammatory cytokines in inflammation, illness responses and pathological pain states (1995) (672)
Stressor controllability and learned helplessness: The roles of the dorsal raphe nucleus, serotonin, and corticotropin-releasing factor (2005) (670)
GLIA: A novel drug discovery target for clinical pain (2003) (659)
Spinal Glia and Proinflammatory Cytokines Mediate Mirror-Image Neuropathic Pain in Rats (2003) (658)
Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation (2005) (649)
Cytokine-to-brain communication: a review & analysis of alternative mechanisms. (1995) (598)
Microglia serve as a neuroimmune substrate for stress-induced potentiation of CNS pro-inflammatory cytokine responses (2007) (504)
Characterization of cytokine-induced hyperalgesia (1994) (498)
Blockade of interleukin-1 induced hyperthermia by subdiaphragmatic vagotomy: evidence for vagal mediation of immune-brain communication (1995) (492)
Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis (2014) (481)
Exposure to Acute Stress Induces Brain Interleukin-1β Protein in the Rat (1998) (472)
Vagal immune-to-brain communication: a visceral chemosensory pathway (2000) (467)
Coping and immunosuppression: inescapable but not escapable shock suppresses lymphocyte proliferation. (1983) (453)
Evidence that opioids may have toll-like receptor 4 and MD-2 effects (2010) (451)
Unpredictable and Uncontrollable Aversive Events (1971) (447)
The Role of the Vagus Nerve in Cytokine‐to‐Brain Communication (1998) (430)
A Role for Proinflammatory Cytokines and Fractalkine in Analgesia, Tolerance, and Subsequent Pain Facilitation Induced by Chronic Intrathecal Morphine (2004) (406)
Learned helplessness at fifty: Insights from neuroscience. (2016) (394)
The pain of being sick: implications of immune-to-brain communication for understanding pain. (2000) (378)
Non‐stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll‐like receptor 4 (TLR4) (2008) (377)
Psychoneuroimmunology. The interface between behavior, brain, and immunity. (1994) (369)
Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions (2004) (367)
Freewheel Running Prevents Learned Helplessness/Behavioral Depression: Role of Dorsal Raphe Serotonergic Neurons (2003) (365)
The "toll" of opioid-induced glial activation: improving the clinical efficacy of opioids by targeting glia. (2009) (365)
Evidence for the involvement of spinal cord glia in subcutaneous formalin induced hyperalgesia in the rat (1997) (359)
Spinal cord glia: new players in pain (2001) (351)
Immune regulation of central nervous system functions: from sickness responses to pathological pain (2005) (349)
Exploring the Neuroimmunopharmacology of Opioids: An Integrative Review of Mechanisms of Central Immune Signaling and Their Implications for Opioid Analgesia (2011) (341)
Opioid-Induced Glial Activation: Mechanisms of Activation and Implications for Opioid Analgesia, Dependence, and Reward (2007) (325)
Glia as the “bad guys”: Implications for improving clinical pain control and the clinical utility of opioids (2007) (322)
Intrathecal HIV-1 Envelope Glycoprotein gp120 Induces Enhanced Pain States Mediated by Spinal Cord Proinflammatory Cytokines (2001) (318)
Peripheral infection and aging interact to impair hippocampal memory consolidation (2006) (318)
Interleukin-1β in Immune Cells of the Abdominal Vagus Nerve: a Link between the Immune and Nervous Systems? (1999) (314)
Glia: novel counter-regulators of opioid analgesia (2005) (310)
Activation of serotonin-immunoreactive cells in the dorsal raphe nucleus in rats exposed to an uncontrollable stressor (1999) (309)
mRNA up-regulation of MHC II and pivotal pro-inflammatory genes in normal brain aging (2006) (305)
The immune system and memory consolidation: a role for the cytokine IL-1β (2001) (305)
A new model of sciatic inflammatory neuritis (SIN): induction of unilateral and bilateral mechanical allodynia following acute unilateral peri-sciatic immune activation in rats (2001) (304)
Glial proinflammatory cytokines mediate exaggerated pain states: implications for clinical pain. (2003) (297)
Learned helplessness and animal models of depression (1984) (296)
Neurocircuitry of illness-induced hyperalgesia (1994) (289)
Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia (2008) (289)
Vagal Paraganglia Bind Biotinylated Interleukin-1 Receptor Antagonist: A Possible Mechanism for Immune-to-Brain Communication (1997) (288)
Evidence that exogenous and endogenous fractalkine can induce spinal nociceptive facilitation in rats (2004) (286)
Bi-directional immune–brain communication: Implications for understanding stress, pain, and cognition (2003) (284)
Prior Stressor Exposure Sensitizes LPS-Induced Cytokine Production (2002) (272)
Alleviation of learned helplessness in the dog. (1968) (272)
Selective Effects of Peripheral Lipopolysaccharide Administration on Contextual and Auditory-Cue Fear Conditioning (1998) (272)
Failure to learn to escape in rats previously exposed to inescapable shock depends on nature of escape response. (1973) (269)
Prior exposure to glucocorticoids sensitizes the neuroinflammatory and peripheral inflammatory responses to E. coli lipopolysaccharide (2010) (269)
Thermal hyperalgesia and mechanical allodynia produced by intrathecal administration of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein, gp120 (2000) (268)
Glucocorticoids mediate stress-induced priming of microglial pro-inflammatory responses (2012) (264)
Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation (2016) (263)
Glial activation and pathological pain (2004) (262)
Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats (2007) (259)
Long-term stress-induced analgesia and activation of the opiate system. (1981) (257)
Role of the medial prefrontal cortex in coping and resilience (2010) (257)
Role of interleukin-1 beta in impairment of contextual fear conditioning caused by social isolation (1999) (249)
Peripheral and central proinflammatory cytokine response to a severe acute stressor (2003) (248)
Implications of immune-to-brain communication for sickness and pain. (1999) (248)
Memory for context is impaired by a post context exposure injection of interleukin-1 beta into dorsal hippocampus (2002) (242)
Neuroinflammation in the normal aging hippocampus (2015) (240)
The impact of the nonpeptide corticotropin-releasing hormone antagonist antalarmin on behavioral and endocrine responses to stress. (1999) (239)
A long-term increase in basal levels of corticosterone and a decrease in corticosteroid-binding globulin after acute stressor exposure. (1995) (239)
Opioid Activation of Toll-Like Receptor 4 Contributes to Drug Reinforcement (2012) (237)
Reduction of opioid withdrawal and potentiation of acute opioid analgesia by systemic AV411 (ibudilast) (2009) (234)
Previous Experience with Behavioral Control over Stress Blocks the Behavioral and Dorsal Raphe Nucleus Activating Effects of Later Uncontrollable Stress: Role of the Ventral Medial Prefrontal Cortex (2006) (230)
Neonatal Infection-Induced Memory Impairment after Lipopolysaccharide in Adulthood Is Prevented via Caspase-1 Inhibition (2005) (224)
Controlling pathological pain by adenovirally driven spinal production of the anti‐inflammatory cytokine, interleukin‐10 (2005) (218)
Escapable and inescapable stress differentially alter extracellular levels of 5-HT in the basolateral amygdala of the rat (1998) (215)
Brain-derived neurotrophic factor mRNA downregulation produced by social isolation is blocked by intrahippocampal interleukin-1 receptor antagonist (2003) (213)
Interleukin-1 mediates the behavioral hyperalgesia produced by lithium chloride and endotoxin (1993) (213)
Mechanisms of tumor necrosis factor-α (TNF-α) hyperalgesia (1995) (213)
Sustained hippocampal IL-1β overexpression impairs contextual and spatial memory in transgenic mice (2010) (212)
Time course of hippocampal IL-1 β and memory consolidation impairments in aging rats following peripheral infection (2009) (207)
Behavioral control, the medial prefrontal cortex, and resilience (2006) (202)
Neonatal infection induces memory impairments following an immune challenge in adulthood. (2005) (201)
Intracisternal Interleukin-1 Receptor Antagonist Prevents Postoperative Cognitive Decline and Neuroinflammatory Response in Aged Rats (2012) (198)
“Listening” and “talking” to neurons: Implications of immune activation for pain control and increasing the efficacy of opioids (2007) (197)
5-Hydroxytryptamine 2C Receptors in the Basolateral Amygdala Are Involved in the Expression of Anxiety After Uncontrollable Traumatic Stress (2010) (195)
Long-term analgesic effects of inescapable shock and learned helplessness. (1979) (194)
Central Proinflammatory Cytokines and Pain Enhancement (2005) (194)
Coping and the stress-induced potentiation of stimulant stereotypy in the rat. (1983) (193)
Differential expression of 5HT‐1A, α1b adrenergic, CRF‐R1, and CRF‐R2 receptor mRNA in serotonergic, γ‐aminobutyric acidergic, and catecholaminergic cells of the rat dorsal raphe nucleus (2004) (192)
BDNF mRNA expression in rat hippocampus following contextual learning is blocked by intrahippocampal IL-1β administration (2004) (188)
Interleukin-1β induced corticosterone elevation and hypothalamic NE depletion is vagally mediated (1995) (188)
Corticotropin Releasing Hormone Type 2 Receptors in the Dorsal Raphe Nucleus Mediate the Behavioral Consequences of Uncontrollable Stress (2003) (182)
Controlling neuropathic pain by adeno-associated virus driven production of the anti-inflammatory cytokine, interleukin-10 (2005) (181)
Intracerebroventricular interleukin-1 receptor antagonist blocks the enhancement of fear conditioning and interference with escape produced by inescapable shock (1995) (180)
Stress Induces the Danger-Associated Molecular Pattern HMGB-1 in the Hippocampus of Male Sprague Dawley Rats: A Priming Stimulus of Microglia and the NLRP3 Inflammasome (2015) (180)
Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia (2008) (178)
The therapeutic potential of interleukin-10 in neuroimmune diseases (2015) (175)
Exposure to inescapable but not escapable shock increases extracellular levels of 5-HT in the dorsal raphe nucleus of the rat (1998) (173)
Microglia inflammatory responses are controlled by an intrinsic circadian clock (2015) (172)
Stress sounds the alarmin: The role of the danger-associated molecular pattern HMGB1 in stress-induced neuroinflammatory priming (2015) (170)
Evidence that intrathecal morphine-3-glucuronide may cause pain enhancement via toll-like receptor 4/MD-2 and interleukin-1β (2010) (170)
Opiate antagonists and long-term analgesic reaction induced by inescapable shock in rats. (1980) (170)
The role of the amygdala and dorsal raphe nucleus in mediating the behavioral consequences of inescapable shock. (1993) (169)
The role of the habenular complex in the elevation of dorsal raphe nucleus serotonin and the changes in the behavioral responses produced by uncontrollable stress (2001) (169)
The Role of Corticotropin-Releasing Hormone in the Dorsal Raphe Nucleus in Mediating the Behavioral Consequences of Uncontrollable Stress (2002) (168)
An initial investigation of spinal mechanisms underlying pain enhancement induced by fractalkine, a neuronally released chemokine (2005) (166)
8-OH-DPAT microinjected in the region of the dorsal raphe nucleus blocks and reverses the enhancement of fear conditioning and interference with escape produced by exposure to inescapable shock. (1995) (165)
DAT isn’t all that: cocaine reward and reinforcement requires Toll Like Receptor 4 signaling (2014) (159)
Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic pain (2006) (159)
Rapid isolation of highly enriched and quiescent microglia from adult rat hippocampus: Immunophenotypic and functional characteristics (2006) (158)
Spinal gap junctions: potential involvement in pain facilitation. (2004) (158)
Escapable and inescapable stress differentially and selectively alter extracellular levels of 5-HT in the ventral hippocampus and dorsal periaqueductal gray of the rat (1998) (157)
Role of fear in mediating shuttle escape learning deficit produced by inescapable shock. (1990) (154)
Sex and estradiol influence glial pro-inflammatory responses to lipopolysaccharide in rats (2012) (154)
The cortical innate immune response increases local neuronal excitability leading to seizures. (2009) (154)
Immune-to-brain communication dynamically modulates pain: Physiological and pathological consequences (2005) (150)
Cholecystokinin antianalgesia: safety cues abolish morphine analgesia. (1992) (146)
Corticosterone: a critical factor in an opioid form of stress-induced analgesia. (1982) (146)
The contribution of the vagus nerve in interleukin-1beta-induced fever is dependent on dose. (2001) (145)
Chronic exposure to exogenous glucocorticoids primes microglia to pro-inflammatory stimuli and induces NLRP3 mRNA in the hippocampus (2014) (145)
“Brain-Specific” Nutrients: A Memory Cure? (2002) (144)
Controllable versus uncontrollable stressors bi-directionally modulate conditioned but not innate fear (2007) (144)
Timecourse and corticosterone sensitivity of the brain, pituitary, and serum interleukin-1β protein response to acute stress (2000) (144)
Activation of the ventral medial prefrontal cortex during an uncontrollable stressor reproduces both the immediate and long-term protective effects of behavioral control (2008) (143)
Involvement of spinal cord nuclear factor κB activation in rat models of proinflammatory cytokine‐mediated pain facilitation (2005) (142)
Librium prevents the analgesia and shuttlebox escape deficit typically observed following inescapable shock (1984) (142)
Stressor Controllability Modulates Stress-Induced Dopamine and Serotonin Efflux and Morphine-Induced Serotonin Efflux in the Medial Prefrontal Cortex (2003) (142)
The consequences of uncontrollable stress are sensitive to duration of prior wheel running (2005) (141)
Further characterization of high mobility group box 1 (HMGB1) as a proinflammatory cytokine: central nervous system effects. (2003) (140)
Interleukin-1 induces c-Fos immunoreactivity in primary afferent neurons of the vagus nerve (1998) (139)
Reduced serum antibodies associated with social defeat in rats (1989) (138)
Chemical lesion of the bed nucleus of the stria terminalis blocks the behavioral consequences of uncontrollable stress. (2004) (137)
Danger Signals and Inflammasomes: Stress-Evoked Sterile Inflammation in Mood Disorders (2017) (137)
Stress-induced glucocorticoids as a neuroendocrine alarm signal of danger (2013) (135)
Controllability, coping behavior, and stress-induced analgesia in the rat (1982) (135)
Stressor controllability and the pituitary-adrenal system. (1986) (135)
Effects of prior stress on LPS-induced cytokine and sickness responses. (2003) (132)
Peri-sciatic proinflammatory cytokines, reactive oxygen species, and complement induce mirror-image neuropathic pain in rats (2004) (130)
Uncontrollable Stress Potentiates Morphine’s Rewarding Properties (1998) (130)
Little Exercise, Big Effects: Reversing Aging and Infection-Induced Memory Deficits, and Underlying Processes (2011) (129)
Learned helplessness, inactivity, and associative deficits: effects of inescapable shock on response choice escape learning. (1980) (129)
Dynamic regulation of the proinflammatory cytokine, interleukin-1beta: molecular biology for non-molecular biologists. (1999) (129)
Blockade of cytokine induced conditioned taste aversion by subdiaphragmatic vagotomy: further evidence for vagal mediation of immune-brain communication (1995) (127)
Exposure to the stressor environment prevents the temporal dissipation of behavioral depression/learned helplessness (2001) (126)
High-fat diet consumption disrupts memory and primes elevations in hippocampal IL-1β, an effect that can be prevented with dietary reversal or IL-1 receptor antagonism (2014) (124)
The estrous cycle and estrogen modulate stress-induced analgesia. (1988) (124)
Learned Helplessness: All of us were Right (And Wrong): Inescapable Shock has Multiple Effects (1979) (123)
High-fat diet and aging interact to produce neuroinflammation and impair hippocampal- and amygdalar-dependent memory (2017) (122)
Enduring consequences of early-life infection on glial and neural cell genesis within cognitive regions of the brain (2010) (122)
Stressor controllability, social interaction, and benzodiazepine systems (1993) (121)
Bacterial Endotoxin Induces Fos Immunoreactivity in Primary Afferent Neurons of the Vagus Nerve (1998) (120)
Microinjection of urocortin 2 into the dorsal raphe nucleus activates serotonergic neurons and increases extracellular serotonin in the basolateral amygdala (2004) (118)
An anxiogenic benzodiazepine receptor ligand induces learned helplessness. (1985) (116)
Thermogenic and corticosterone responses to intravenous cytokines (IL-1β and TNF-α) are attenuated by subdiaphragmatic vagotomy (1998) (116)
Exposure to inescapable shock produces both activity and associative deficits in the rat (1978) (116)
"Brain-specific" nutrients: a memory cure? (2003) (114)
Stressor Controllability, Anxiety, and Serotonin (1998) (113)
Spinal upregulation of glutamate transporter GLT-1 by ceftriaxone: therapeutic efficacy in a range of experimental nervous system disorders (2010) (113)
Prior stressor exposure primes the HPA axis (2002) (113)
Stressor Controllability and Stress‐Induced Analgesia (1986) (113)
Behavioral control blunts reactions to contemporaneous and future adverse events: Medial prefrontal cortex plasticity and a corticostriatal network (2014) (111)
Early-life infection leads to altered BDNF and IL-1β mRNA expression in rat hippocampus following learning in adulthood (2008) (111)
The opioid/nonopioid nature of stress-induced analgesia and learned helplessness. (1983) (110)
Possible involvement of toll-like receptor 4/myeloid differentiation factor-2 activity of opioid inactive isomers causes spinal proinflammation and related behavioral consequences (2010) (110)
The role of IL-1β in stress-induced sensitization of proinflammatory cytokine and corticosterone responses (2004) (110)
A method for increasing the viability of the external portion of lumbar catheters placed in the spinal subarachnoid space of rats (1999) (110)
Immune-to-central nervous system communication and its role in modulating pain and cognition: Implications for cancer and cancer treatment (2003) (109)
Aging and a Peripheral Immune Challenge Interact to Reduce Mature Brain-Derived Neurotrophic Factor and Activation of TrkB, PLCγ1, and ERK in Hippocampal Synaptoneurosomes (2011) (108)
Effects of vagotomy on serum endotoxin, cytokines, and corticosterone after intraperitoneal lipopolysaccharide. (2000) (104)
Spinal pain suppression mechanisms may differ for phasic and tonic pain (1985) (104)
Effects of task-irrelevant cues and reinforcement delay on choice-escape learning following inescapable shock: evidence for a deficit in selective attention. (1984) (103)
Differential expression of 5HT-1A, alpha 1b adrenergic, CRF-R1, and CRF-R2 receptor mRNA in serotonergic, gamma-aminobutyric acidergic, and catecholaminergic cells of the rat dorsal raphe nucleus. (2004) (103)
The redox state of the alarmin HMGB1 is a pivotal factor in neuroinflammatory and microglial priming: A role for the NLRP3 inflammasome (2016) (103)
A behavioural characterization of neonatal infection-facilitated memory impairment in adult rats (2006) (102)
The immune system and memory consolidation: a role for the cytokine IL-1beta. (2001) (102)
Enduring Reversal of Neuropathic Pain by a Single Intrathecal Injection of Adenosine 2A Receptor Agonists: A Novel Therapy for Neuropathic Pain (2009) (102)
Expression of c-fos and BDNF mRNA in subregions of the prefrontal cortex of male and female rats after acute uncontrollable stress (2005) (101)
Subcutaneous formalin produces centrifugal hyperalgesia at a non-injected site via the NMDA-nitric oxide cascade (1994) (101)
Selective activation of dorsal raphe nucleus‐projecting neurons in the ventral medial prefrontal cortex by controllable stress (2009) (100)
The role of prior stressor controllability and the dorsal raphé nucleus in sucrose preference and social exploration (2008) (100)
(+)-naloxone, an opioid-inactive toll-like receptor 4 signaling inhibitor, reverses multiple models of chronic neuropathic pain in rats. (2012) (100)
Intrathecal polymer-based interleukin-10 gene delivery for neuropathic pain. (2006) (100)
HIV-1 gp120 Stimulates proinflammatory cytokine-mediated pain facilitation via activation of nitric oxide synthase-I (nNOS) (2004) (99)
Transituational Immunization and Therapy of Learned Helplessness in the Rat. (1977) (98)
Evidence that tricyclic small molecules may possess toll-like receptor and myeloid differentiation protein 2 activity (2010) (97)
Aging sensitizes rapidly isolated hippocampal microglia to LPS ex vivo (2010) (96)
Uncontrollable, But Not Controllable, Stress Desensitizes 5-HT1A Receptors in the Dorsal Raphe Nucleus (2011) (96)
Suppression of specific antibody production by inescapable shock: Stability under varying conditions (1988) (96)
Differential effects of neonatal handling on early life infection-induced alterations in cognition in adulthood (2007) (96)
Prior voluntary wheel running attenuates neuropathic pain (2016) (95)
Stress-induced neuroinflammatory priming: A liability factor in the etiology of psychiatric disorders (2015) (93)
Medial prefrontal cortical activation modulates the impact of controllable and uncontrollable stressor exposure on a social exploration test of anxiety in the rat (2009) (93)
Anti-inflammatory cytokine gene therapy decreases sensory and motor dysfunction in experimental Multiple Sclerosis: MOG-EAE behavioral and anatomical symptom treatment with cytokine gene therapy (2009) (93)
Memory impairments in healthy aging: Role of aging-induced microglial sensitization. (2010) (92)
Influence of control of shock on subsequent shock-elicited aggression. (1972) (92)
The glial activation inhibitor AV411 reduces morphine-induced nucleus accumbens dopamine release (2009) (92)
A robust activity marking system for exploring active neuronal ensembles (2016) (92)
The Sensory Insular Cortex Mediates the Stress-Buffering Effects of Safety Signals But Not Behavioral Control (2008) (92)
Failure to learn to escape by rats previously exposed to inescapable shock is partly produced by associative interference. (1975) (91)
Stress- and glucocorticoid-induced priming of neuroinflammatory responses: Potential mechanisms of stress-induced vulnerability to drugs of abuse (2011) (90)
Evidence that brief stress may induce the acute phase response in rats. (1997) (90)
Safety Signals Mitigate the Consequences of Uncontrollable Stress Via a Circuit Involving the Sensory Insular Cortex and Bed Nucleus of the Stria Terminalis (2011) (90)
Acute stressor exposure both suppresses acquired immunity and potentiates innate immunity. (1998) (89)
Determinants of the nature of environmentally induced hypoalgesia. (1989) (89)
Aging and infection reduce expression of specific brain-derived neurotrophic factor mRNAs in hippocampus (2012) (88)
Pain intensity and duration can be enhanced by prior challenge: initial evidence suggestive of a role of microglial priming. (2010) (88)
Extent and control of shock affects naltrexone sensitivity of stress-induced analgesia and reactivity to morphine (1982) (87)
Behavioral control over shock blocks behavioral and neurochemical effects of later social defeat (2010) (87)
Nitroxidative Signaling Mechanisms in Pathological Pain (2016) (85)
Inescapable shock activates serotonergic neurons in all raphe nuclei of rat (2004) (84)
The Simplicity Principle in Human Concept Learning (84)
Acute and conditioned hyperalgesic responses to illness (1994) (84)
The dorsal raphe nucleus is a site of action mediating the behavioral effects of the benzodiazepine receptor inverse agonist DMCM. (1995) (83)
Mechanisms of tumor necrosis factor-alpha (TNF-alpha) hyperalgesia. (1995) (82)
IL-1RA blocks E. coli-induced suppression of Arc and long-term memory in aged F344×BN F1 rats (2010) (81)
The Alarmin HMGB1 Mediates Age-Induced Neuroinflammatory Priming (2016) (81)
Human immunodeficiency virus-1 coat protein gp120 impairs contextual fear conditioning: a potential role in AIDS related learning and memory impairments (2000) (80)
Activation of the infralimbic cortex in a fear context enhances extinction learning. (2010) (79)
Failure to escape traumatic electric shock: Incompatible skeletal-motor responses or learned helplessness?☆ (1970) (79)
Sciatic inflammatory neuritis (SIN): Behavioral allodynia is paralleled by peri‐sciatic proinflammatory cytokine and superoxide production (2001) (77)
Comparison of the effects of nucleus tractus solitarius and ventral medial medulla lesions on illness-induced and subcutaneous formalin-induced hyperalgesias (1997) (77)
Evidence for a role of heat shock protein-90 in toll like receptor 4 mediated pain enhancement in rats (2009) (77)
Chlordiazepoxide microinjected into the region of the dorsal raphe nucleus eliminates the interference with escape responding produced by inescapable shock whether administered before inescapable shock or escape testing. (1994) (77)
Cross tolerance between morphine and the long-term analgesic reaction to inescapable shock (1981) (77)
Expression of fibroblast growth factor-2 and brain-derived neurotrophic factor mRNA in the medial prefrontal cortex and hippocampus after uncontrollable or controllable stress (2007) (76)
Opioid‐Induced Central Immune Signaling: Implications for Opioid Analgesia (2015) (75)
Long-term effects of inescapable stress on daily running activity and antagonism by desipramine (1988) (75)
Effects of vagotomy on lipopolysaccharide-induced brain interleukin-1β protein in rats (2000) (74)
The amygdala is necessary for the expression of conditioned but not unconditioned analgesia. (1993) (73)
Snake venom phospholipase A2s (Asp49 and Lys49) induce mechanical allodynia upon peri-sciatic administration: involvement of spinal cord glia, proinflammatory cytokines and nitric oxide (2004) (71)
Exercise does not modify spatial memory, brain autoimmunity, or antibody response in aged F-344 rats (1991) (70)
Blocking toll-like receptor 2 and 4 signaling during a stressor prevents stress-induced priming of neuroinflammatory responses to a subsequent immune challenge (2013) (70)
Inescapable shock induces resistance to the effects of dexamethasone (2003) (70)
Synaptic Correlates of Increased Cognitive Vulnerability with Aging: Peripheral Immune Challenge and Aging Interact to Disrupt Theta-Burst Late-Phase Long-Term Potentiation in Hippocampal Area CA1 (2010) (69)
Neuroinflammatory priming to stress is differentially regulated in male and female rats (2018) (69)
Bacterial infection early in life protects against stressor-induced depressive-like symptoms in adult rats (2008) (69)
Impaired escape performance and enhanced conditioned fear in rats following exposure to an uncontrollable stressor are mediated by glutamate and nitric oxide in the dorsal raphe nucleus (2000) (69)
Dynamic regulation of proinflammatory cytokines. (1999) (69)
Long-term changes in mineralocorticoid and glucocorticoid receptor occupancy following exposure to an acute stressor (1999) (68)
Illness-induced hyperalgesia is mediated by spinal neuropeptides and excitatory amino acids (1994) (67)
The neurobiology of the stress-resistant brain (2011) (66)
Preferences for tastes paired with recovery from thiamine deficiency in rats: appetitive conditioning or learned safety? (1974) (65)
Aging-related changes in neuroimmune-endocrine function: Implications for hippocampal-dependent cognition (2012) (65)
Prostaglandins are necessary and sufficient to induce contextual fear learning impairments after interleukin-1 beta injections into the dorsal hippocampus (2007) (65)
Interleukin-6 mediates low-threshold mechanical allodynia induced by intrathecal HIV-1 envelope glycoprotein gp120 (2007) (65)
Subdiaphragmatic vagotomy does not block intraperitoneal lipopolysaccharide-induced fever (2000) (64)
Characterization of the sickness response in young and aging rats following E. coli infection (2009) (64)
Analgesic and opioid involvement in the shock-elicited activity and escape deficits produced by inescapable shock☆ (1983) (63)
Previous Ketamine Produces an Enduring Blockade of Neurochemical and Behavioral Effects of Uncontrollable Stress (2016) (63)
Targeting the Toll of Drug Abuse: The Translational Potential of Toll-Like Receptor 4. (2015) (63)
Conditioned analgesia in the rat (1980) (62)
Role of the ventral medial prefrontal cortex in mediating behavioral control-induced reduction of later conditioned fear. (2008) (61)
Low doses of corticotropin-releasing hormone injected into the dorsal raphe nucleus block the behavioral consequences of uncontrollable stress (2003) (61)
Snake venom components enhance pain upon subcutaneous injection: an initial examination of spinal cord mediators (2004) (60)
Inescapable shock, shock controllability, and mitogen stimulated lymphocyte proliferation (1988) (60)
Activation of the spinal cord complement cascade might contribute to mechanical allodynia induced by three animal models of spinal sensitization. (2005) (59)
Immunization with Mycobacterium vaccae induces an anti-inflammatory milieu in the CNS: Attenuation of stress-induced microglial priming, alarmins and anxiety-like behavior (2018) (59)
Coping and seizure susceptibility: Control over shock protects against bicuculline-induced seizures (1985) (58)
DREADDed microglia in pain: Implications for spinal inflammatory signaling in male rats (2018) (58)
A novel method for modeling facial allodynia associated with migraine in awake and freely moving rats (2010) (58)
Greater glucocorticoid receptor activation in hippocampus of aged rats sensitizes microglia (2015) (58)
Activation of adult rat CNS endothelial cells by opioid-induced toll-like receptor 4 (TLR4) signaling induces proinflammatory, biochemical, morphological, and behavioral sequelae (2014) (58)
Parallel activation of multiple spinal opiate systems appears to mediate ‘non-opiate’ stress-induced analgesias (1992) (58)
Shock controllability and the nature of stress-induced analgesia. (1985) (58)
Caudal Granular Insular Cortex Is Sufficient and Necessary for the Long-Term Maintenance of Allodynic Behavior in the Rat Attributable to Mononeuropathy (2011) (58)
Effect of number of tailshocks on learned helplessness and activation of serotonergic and noradrenergic neurons in the rat (2005) (58)
Stress-induced neuroinflammatory priming is time of day dependent (2016) (57)
Circulating cytokines and endotoxin are not necessary for the activation of the sickness or corticosterone response produced by peripheral E. coli challenge. (2003) (57)
Acute Stress May Facilitate Recovery from a Subcutaneous Bacterial Challenge (1999) (57)
The elevated plus-maze is not sensitive to the effect of stressor controllability in rats (1995) (57)
Conditioned inhibition and the UCS-CS interval (1976) (57)
Elevated IL-1beta contributes to antibody suppression produced by stress. (2002) (56)
Session III: Mechanisms of age-related cognitive change and targets for intervention: inflammatory, oxidative, and metabolic processes. (2012) (55)
Microglia: Neuroimmune-sensors of stress. (2019) (55)
RU-486 blocks differentially suppressive effect of stress on in vivo anti-KLH immunoglobulin response. (1996) (55)
Behavioral control of the stressor modulates stress-induced changes in neurogenesis and fibroblast growth factor-2 (2006) (55)
Control over Stress, But Not Stress Per Se Increases Prefrontal Cortical Pyramidal Neuron Excitability (2012) (55)
Stress disinhibits microglia via down-regulation of CD200R: A mechanism of neuroinflammatory priming (2017) (55)
Morphine amplifies mechanical allodynia via TLR4 in a rat model of spinal cord injury (2016) (54)
Inescapable shock and food-competition dominance in rats (1978) (53)
Neurocircuitry of conditioned inhibition of analgesia: effects of amygdala, dorsal raphe, ventral medullary, and spinal cord lesions on antianalgesia in the rat. (1998) (53)
Stress and aging act through common mechanisms to elicit neuroinflammatory priming (2018) (53)
Opioid and nonopioid interactions in two forms of stress-induced analgesia (1993) (53)
Protraction of neuropathic pain by morphine is mediated by spinal damage associated molecular patterns (DAMPs) in male rats (2017) (53)
Glucocorticoids Mediate Short-Term High-Fat Diet Induction of Neuroinflammatory Priming, the NLRP3 Inflammasome, and the Danger Signal HMGB1 (2016) (52)
A novel immune-to-CNS communication pathway: Cells of the meninges surrounding the spinal cord CSF space produce proinflammatory cytokines in response to an inflammatory stimulus (2007) (52)
SARS-CoV-2 spike S1 subunit induces neuroinflammatory, microglial and behavioral sickness responses: Evidence of PAMP-like properties (2021) (52)
5-hydroxytryptamine 2C receptors in the dorsal striatum mediate stress-induced interference with negatively reinforced instrumental escape behavior (2011) (51)
Specific changes in lymphocyte subpopulations: a potential mechanism for stress-induced immunomodulation (1992) (51)
Operant and Pavlovian factors in cross-response transfer of inhibitory stimulus control (1978) (51)
Prior exposure to glucocorticoids potentiates lipopolysaccharide induced mechanical allodynia and spinal neuroinflammation (2011) (51)
Kappa opiate receptors mediate tail-shock induced antinociception at spinal levels (1992) (51)
Glucuronic acid and the ethanol metabolite ethyl-glucuronide cause toll-like receptor 4 activation and enhanced pain (2013) (50)
The danger-associated molecular pattern HMGB1 mediates the neuroinflammatory effects of methamphetamine (2016) (50)
Endogenous Glucocorticoids Play a Positive Regulatory Role in the Anti-Keyhole Limpet Hemocyanin In Vivo Antibody Response (2001) (50)
Bidirectional communication between the brain and the immune system: implications for behaviour (1999) (49)
Systemic administration of CNI-1493, a p38 mitogen-activated protein kinase inhibitor, blocks intrathecal human immunodeficiency virus-1 gp120-induced enhanced pain states in rats. (2001) (49)
Activation of a Habenulo–Raphe Circuit Is Critical for the Behavioral and Neurochemical Consequences of Uncontrollable Stress in the Male Rat (2016) (48)
Systemic administration of an alpha-7 nicotinic acetylcholine agonist reverses neuropathic pain in male Sprague Dawley rats. (2012) (48)
Prior exposure to repeated morphine potentiates mechanical allodynia induced by peripheral inflammation and neuropathy (2012) (48)
Systemic administration of propentofylline, ibudilast, and (+)-naltrexone each reverses mechanical allodynia in a novel rat model of central neuropathic pain. (2014) (47)
Spinal cord glia and interleukin-1 do not appear to mediate persistent allodynia induced by intramuscular acidic saline in rats. (2006) (47)
Stressor controllability modulates stress‐induced serotonin but not dopamine efflux in the nucleus accumbens shell (2003) (47)
Antibodies against N-methyl-D-aspartate receptors in patients with systemic lupus erythematosus without major neuropsychiatric syndromes (2010) (46)
Staphylococcal enterotoxin B induces fever, brain c-Fos expression, and serum corticosterone in rats. (2001) (46)
Thermogenic and corticosterone responses to intravenous cytokines (IL-1beta and TNF-alpha) are attenuated by subdiaphragmatic vagotomy. (1998) (46)
Surgical and pharmacological suppression of glucocorticoids prevents the enhancement of morphine conditioned place preference by uncontrollable stress in rats (2005) (46)
Beyond Depression: Towards a Process-Based Approach to Research, Diagnosis, and Treatment. (2011) (45)
Behavioral assessment of neuropathic pain, fatigue, and anxiety in experimental autoimmune encephalomyelitis (EAE) and attenuation by interleukin-10 gene therapy (2017) (44)
Stress-induced reduction in the rat mixed lymphocyte reaction is due to macrophages and not to changes in T cell phenotypes (1995) (44)
Intrathecal injection of an alpha seven nicotinic acetylcholine receptor agonist attenuates gp120-induced mechanical allodynia and spinal pro-inflammatory cytokine profiles in rats (2010) (44)
Appetitive conditioning with recovery from thiamine deficiency as the unconditioned stimulus (1969) (44)
Diazepam modulation of stress-induced analgesia depends on the type of analgesia. (1990) (44)
Vagotomy does not inhibit high dose lipopolysaccharide-induced interleukin-1β immunoreactivity in rat brain and pituitary gland (2000) (43)
Stress-Induced Sensitization of the Hypothalamic-Pituitary Adrenal Axis Is Associated with Alterations of Hypothalamic and Pituitary Gene Expression (2005) (43)
Suppression of voluntary wheel running in rats is dependent on the site of inflammation: evidence for voluntary running as a measure of hind paw-evoked pain. (2014) (43)
Learned helplessness: Relationships with fear and anxiety. (1993) (43)
The time course of learned helplessness, inactivity, and nociceptive deficits in rats (1979) (43)
Methamphetamine activates Toll-like receptor 4 to induce central immune signaling within the ventral tegmental area and contributes to extracellular dopamine increase in the nucleus accumbens shell. (2019) (42)
Control over a stressor involves the posterior dorsal striatum and the act/outcome circuit (2014) (42)
Diminished circadian rhythms in hippocampal microglia may contribute to age-related neuroinflammatory sensitization (2016) (42)
Inescapable shock and attention to internal versus external cues in a water discrimination escape task. (1988) (42)
Opiate and non-opiate analgesia induced by inescapable tail-shock: Effects of dorsolateral funiculus lesions and decerebration (1984) (42)
The effects of a single exposure to uncontrollable stress on the subsequent conditioned place preference responses to oxycodone, cocaine, and ethanol in rats (2007) (41)
Stressed Rats Fail to Expand the CD45RC+CD4+ (Th1-Like) T-Cell Subset in Response to KLH: Possible Involvement of IFN-γ (1995) (41)
The role of glucocorticoids in the uncontrollable stress-induced potentiation of nucleus accumbens shell dopamine and conditioned place preference responses to morphine (2006) (41)
Monoamine neurotransmitters and metabolites during the estrous cycle, pregnancy, and the postpartum period (1988) (41)
No spatial learning impairment following exposure to inescapable shock (1991) (41)
Morphine-Induced Decreases in in Vivo Antibody Responses (1994) (41)
A role for G protein‐coupled receptor kinase 2 in mechanical allodynia (2007) (41)
Short- and long-term consequences of stressor controllability in adolescent rats (2012) (41)
Blockade of alpha1 adrenoreceptors in the dorsal raphe nucleus prevents enhanced conditioned fear and impaired escape performance following uncontrollable stressor exposure in rats (2002) (40)
Stress, Learned Helplessness, and Brain Interleukin-1β (1999) (40)
Posterior insular cortex is necessary for conditioned inhibition of fear (2016) (39)
Evidence that brief stress may induce the acute phase response in rats. (1997) (39)
The Medial Prefrontal Cortex Regulates the Differential Expression of Morphine-Conditioned Place Preference Following a Single Exposure to Controllable or Uncontrollable Stress (2009) (39)
Widespread Periodic Intrinsic Connections in the Tree Shrew Visual Cortex (2005) (39)
The long term acute phase-like responses that follow acute stressor exposure are blocked by alpha-melanocyte stimulating hormone (1998) (38)
Uncontrollable shock, forebrain norepinephrine, and stimulus selection during choice-escape learning (1988) (38)
The permissive role of glucocorticoids in neuroinflammatory priming: mechanisms and insights (2015) (38)
The nature of conditioned anti-analgesia: spinal cord opiate and anti-opiate neurochemistry (1994) (38)
A permissive role of corticosterone in an opioid form of stress-induced analgesia: blockade of opiate analgesia is not due to stress-induced hormone release (1994) (37)
Electrolytic lesions and pharmacological inhibition of the dorsal raphe nucleus prevent stressor potentiation of morphine conditioned place preference in rats (2003) (37)
Long-term control of neuropathic pain in a non-viral gene therapy paradigm (2009) (37)
Intrathecal injection of adenosine 2A receptor agonists reversed neuropathic allodynia through protein kinase (PK)A/PKC signaling (2013) (37)
Shock signals and the development of stress-induced analgesia. (1987) (36)
Stress-induced activity in the locus coeruleus is not sensitive to stressor controllability (2009) (36)
Mycobacterium vaccae immunization protects aged rats from surgery-elicited neuroinflammation and cognitive dysfunction (2018) (36)
Running Reduces Uncontrollable Stress-Evoked Serotonin and Potentiates Stress-Evoked Dopamine Concentrations in the Rat Dorsal Striatum (2015) (36)
Opioid-dependent effects of inescapable shock on escape behavior and conditioned fear responding are mediated by the dorsal raphe nucleus (1999) (36)
Subdiaphragmatic vagotomy does not prevent fever following intracerebroventricular prostaglandin E2: further evidence for the importance of vagal afferents in immune-to-brain communication (1997) (36)
Dissociation of long-term analgesia and the shuttle box escape deficit caused by inescapable shock. (1982) (36)
Repeated Morphine Prolongs Postoperative Pain in Male Rats (2019) (36)
Associative and non-associative mechanisms of morphine analgesic tolerance are neurochemically distinct in the rat spinal cord (1996) (35)
Opioid and nonopioid forms of stress-induced analgesia: some environmental determinants and characteristics. (1982) (35)
Exploring acute-to-chronic neuropathic pain in rats after contusion spinal cord injury (2017) (34)
A method for measuring multiple cytokines from small samples (2004) (33)
Stress potentiation of morphine-induced dopamine efflux in the nucleus accumbens shell is dependent upon stressor uncontrollability and is mediated by the dorsal raphe nucleus (2004) (33)
Subdiaphragmatic vagotomy blocks interleukin-1β-induced fever but does not reduce IL-1β levels in the circulation (2000) (33)
Neonatal bacterial infection alters fever to live and simulated infections in adulthood (2010) (33)
Endogenous pain facilitory systems Antianalgesia and hyperalgesia (1992) (32)
Immunological priming potentiates non-viral anti-inflammatory gene therapy treatment of neuropathic pain (2009) (32)
Route of morphine administration modulates conditioned analgesic tolerance and hyperalgesia (1994) (32)
Blockade of the hypothalamic-pituitary-adrenal response to stress by intraventricular injection of dexamethasone: A method for studying the stress-induced peripheral effects of glucocorticoids (1993) (32)
Differential Expression of 5 HT-1 A , α 1 b Adrenergic , CRF-R 1 , and CRF-R 2 Receptor mRNA in Serotonergic , γ-Aminobutyric Acidergic , and Catecholaminergic Cells of the Rat Dorsal Raphe Nucleus (2008) (32)
Learned stressor resistance requires extracellular signal-regulated kinase in the prefrontal cortex (2014) (32)
Characterization of the temporo-spatial effects of chronic bilateral intrahippocampal cannulae on interleukin-1β (2007) (31)
Exposure to uncontrollable stress alters withdrawal from morphine. (1984) (31)
Inhibition of a Descending Prefrontal Circuit Prevents Ketamine-Induced Stress Resilience in Females (2018) (31)
Voluntary wheel running produces resistance to inescapable stress-induced potentiation of morphine conditioned place preference (2011) (31)
Behavioural and neural sequelae of stressor exposure are not modulated by controllability in females (2018) (31)
Controllable stress elicits circuit-specific patterns of prefrontal plasticity in males, but not females (2019) (30)
Anesthesia‐Induced Modulation of In Vivo Antibody Levels: A Study of Pentobarbital, Chloral Hydrate, Methoxyflurane, Halothane, and Ketamine/Xylazine (1993) (30)
The nature of the activity deficit produced by inescapable shock (1982) (30)
Inescapable shock-induced potentiation of morphine analgesia in rats: involvement of opioid, GABAergic, and serotonergic mechanisms in the dorsal raphe nucleus. (1997) (30)
Below level central pain induced by discrete dorsal spinal cord injury. (2010) (30)
Neonatal Escherichia coli infection alters glial, cytokine, and neuronal gene expression in response to acute amphetamine in adolescent rats (2010) (29)
From Helplessness To Hope: The Seminal Career Of Martin Seligman (2000) (28)
Relative novelty of solid and liquid diet during thiamine deficiency determines development of thiamine-specific hunger. (1971) (27)
Delta opiate receptors mediate tail-shock induced antinociception at supraspinal levels (1992) (27)
The nature of the initial coping response and the learned helplessness effect (1977) (27)
TNF-α–Induced Corticosterone Elevation But Not Serum Protein or Corticosteroid Binding Globulin Reduction Is Vagally Mediated (1997) (26)
Proactive interference in rats (1967) (26)
A minocycline derivative reduces nerve injury-induced allodynia, LPS-induced prostaglandin E2 microglial production and signaling via toll-like receptors 2 and 4 (2013) (26)
Factors that modulate inescapable shock-induced reductions in daily activity in the rat (1993) (26)
Behavioral changes in rats after acute, chronic and repeated administration of interleukin-1beta: relevance for affective disorders. (2003) (26)
Sustained reversal of central neuropathic pain induced by a single intrathecal injection of adenosine A2A receptor agonists (2018) (25)
Immunization of opioid analgesia: Effects of prior escapable shock on subsequent shock-induced and morphine-induced antinociception (1983) (25)
Two models of inescapable stress increase tph2 mRNA expression in the anxiety-related dorsomedial part of the dorsal raphe nucleus (2018) (25)
MicroRNA-124 and microRNA-146a both attenuate persistent neuropathic pain induced by morphine in male rats (2018) (25)
Total plasma cholesterol levels of rats are increased following only three sessions of tailshock. (1992) (24)
Pattern recognition receptors mediate pro-inflammatory effects of extracellular mitochondrial transcription factor A (TFAM) (2018) (24)
Active behavioral coping alters the behavioral but not the endocrine response to stress (2012) (24)
Effects of individual housing and stressor exposure upon the acquisition of watermaze escape (1986) (23)
Sciatic inflammatory neuropathy in the rat: surgical procedures, induction of inflammation, and behavioral testing. (2004) (22)
Inescapable but not escapable stress leads to increased struggling behavior and basolateral amygdala c-fos gene expression in response to subsequent novel stress challenge (2010) (22)
Acute stressor exposure both suppresses acquired immunity and potentiates innate immunity. (1998) (22)
A novel platform for in vivo detection of cytokine release within discrete brain regions (2018) (22)
Modulation of the locomotor properties of morphine and amphetamine by uncontrollable stress (2002) (22)
Reversal of spinal cord non-opiate analgesia by conditioned anti-analgesia in the rat (1997) (22)
Controllability and safety signals exert dissimilar proactive effects on nociception and escape performance. (1988) (21)
Therapy and immunization of long-term analgesia in rats (1981) (21)
Potentiation, overshadowing, and prior exposure to inescapable shock. (1987) (21)
Supradural inflammatory soup in awake and freely moving rats induces facial allodynia that is blocked by putative immune modulators (2017) (21)
Could Probiotics Be Used to Mitigate Neuroinflammation? (2019) (21)
Prior laparotomy or corticosterone potentiates lipopolysaccharide-induced fever and sickness behaviors (2011) (20)
Stress-induced glucocorticoids suppress the antisense molecular regulation of FGF-2 expression (2007) (20)
IL-1RA injected intra-cisterna magna confers extended prophylaxis against lipopolysaccharide-induced neuroinflammatory and sickness responses (2012) (20)
Effects of Adolescent Caffeine Consumption on Cocaine Sensitivity (2015) (20)
Acute stress induces chronic neuroinflammatory, microglial and behavioral priming: A role for potentiated NLRP3 inflammasome activation (2020) (20)
Adinazolam both prevents and reverses the long-term reduction of daily activity produced by inescapable shock (1990) (20)
Effects of stressor controllability on diurnal physiological rhythms (2013) (20)
Prefrontal cortex serotonin, stress, and morphine-induced nucleus accumbens dopamine (2004) (20)
Conditioned and unconditioned stress-induced analgesia: Stimulus preexposure and stimulus change (1991) (19)
Stressor Exposure Produces Long-term Reductions in Antigen-specific T and B Cell Responses (2003) (19)
Spinal Cord Injury in Rats Disrupts the Circadian System (2018) (19)
Conditioned inhibition of analgesia (1992) (19)
Cytokines and Pain (1998) (18)
Targeting glia to control clinical pain: an idea whose time has come (2004) (18)
Prior exposure to inescapable electric shock in rats affects extinction behavior after the successful acquisition of an escape response (1974) (18)
The Immune System as a Sensory System (2000) (18)
Postoperative cognitive dysfunction is made persistent with morphine treatment in aged rats (2020) (18)
Inescapable shock-induced potentiation of morphine analgesia. (1997) (17)
Activation of the medial prefrontal cortex by escapable stress is necessary for protection against subsequent inescapable stress‐induced potentiation of morphine conditioned place preference (2012) (17)
Anxiogenic effects of brief swim stress are sensitive to stress history (2013) (17)
Chapter 22 Contribution of glia to pain processing in health and disease. (2006) (17)
D2 dopamine receptors in the rat prefrontal cortex: characterization and alteration by stress (1989) (17)
Oxycodone, fentanyl, and morphine amplify established neuropathic pain in male rats. (2019) (16)
Stress, learned helplessness, and brain interleukin-1 beta. (1999) (16)
The role of the amygdala and dorsal raphe nucleus in mediating the behavioral consequences of inescapable shock (1993) (16)
Understanding stress resilience (2013) (16)
Aging and miR-155 in mice influence survival and neuropathic pain after spinal cord injury (2021) (16)
When Good Pain Turns Bad (2003) (15)
Select steroid hormone glucuronide metabolites can cause toll-like receptor 4 activation and enhanced pain (2015) (15)
Peripheral β-Adrenoreceptors and Stress-Induced Hypercholesterolemia in Rats (1996) (14)
Subdiaphragmatic vagotomy blocks interleukin-1beta-induced fever but does not reduce IL-1beta levels in the circulation. (2000) (14)
Morphine-induced alterations in antibody levels: receptor and immune mechanisms. (1996) (13)
Opioid peptides as neuroregulators: Potential areas for the study of genetic-behavioral mechanisms (1982) (13)
The formalin test and the opioid nature of stress-induced analgesia. (1984) (13)
New tools for understanding coping and resilience (2017) (12)
Proactive inhibition in rats after prior partial reversal: A critique of the spontaneous recovery hypothesis (1967) (12)
Modulation of the in vivo antibody response by a benzodiazepine inverse agonist (DMCM) administered centrally or peripherally (1993) (12)
Post-conditioning experience with acute or chronic inflammatory pain reduces contextual fear conditioning in the rat (2012) (12)
OPIOID AND NONOPIOID MECHANISMS OF STRESS-INDUCED ANALGESIA (1981) (11)
A single peri-sciatic nerve administration of the adenosine 2A receptor agonist ATL313 produces long-lasting anti-allodynia and anti-inflammatory effects in male rats (2019) (11)
Adenosine 2A receptor agonism: A single intrathecal administration attenuates motor paralysis in experimental autoimmune encephalopathy in rats (2015) (11)
Learned helplessness and the schedule-shift hypotheses (1980) (11)
Circadian misalignment has differential effects on affective behavior following exposure to controllable or uncontrollable stress (2019) (11)
The decrement in conditioned fear with increased trials of simultaneous conditioning is not specific to the simultaneous procedure (1978) (11)
Glucocorticoids mediate stress induction of the alarmin HMGB1 and reduction of the microglia checkpoint receptor CD200R1 in limbic brain structures (2019) (11)
Molecular changes during learning: behavioral strategy--a comment on Gaito and Bonnet. (1972) (10)
Experimental autoimmune encephalopathy (EAE)-induced hippocampal neuroinflammation and memory deficits are prevented with the non-opioid TLR2/TLR4 antagonist (+)-naltrexone (2020) (10)
The case of the missing brain: Arguments for a role of brain-to-spinal cord pathways in pain facilitation (1997) (10)
Spinal Cord Injury in Rats Dysregulates Diurnal Rhythms of Fecal Output and Liver Metabolic Indicators. (2019) (10)
The benzodiazepine receptor antagonists flumazenil and CGS8216 block the enhancement of fear conditioning and interference with escape behavior produced by inescapable shock (1995) (10)
Review: neuronal-glial interactions in central sensitization (2003) (9)
The role of hepatic and splenic macrophages in E. coli-induced memory impairments in aged rats (2015) (9)
Fear, Stimulus Feedback, and Stressor Controllability (1989) (8)
Dissociation of interference with the speed and accuracy of escape produced by inescapable shock. (1993) (8)
Escape learning deficit after overcrowded rearing in rats: Test of a helplessness hypothesis (1974) (8)
Aging and an Immune Challenge Interact to Produce Prolonged, but Not Permanent, Reductions in Hippocampal L-LTP and mBDNF in a Rodent Model with Features of Delirium (2018) (8)
Stable, long-term, spatial memory in young and aged rats achieved with a one day Morris water maze training protocol (2016) (7)
Toll-like receptor 2 and 4 antagonism for the treatment of experimental autoimmune encephalomyelitis (EAE)-related pain (2020) (7)
Mechanisms of Glial Activation after Nerve Injury (2008) (7)
Comparing the effects of two different strains of mycobacteria, Mycobacterium vaccae NCTC 11659 and M. vaccae ATCC 15483, on stress-resilient behaviors and lipid-immune signaling in rats (2020) (7)
Competing Motor Responses: A Reply to Black. (1977) (7)
The Impact of the Nonpeptide Corticotropin-Releasing Hormone Antagonist Antalarmin on Behavioral and Endocrine Responses to Stress* *This research was supported by NIMH Grant MH-50479 and the Undergraduate Research Opportunities Program at the University of Colorado at Boulder. (1999) (7)
Illness-induced hyperalgesia: Mediators, mechanisms and implications (1999) (7)
Suppression of active phase voluntary wheel running in male rats by unilateral chronic constriction injury: Enduring therapeutic effects of a brief treatment of morphine combined with TLR4 or P2X7 antagonists (2020) (6)
Animal Models of Chronic Pain: Chronic Constriction Injury induced pathological pain states are controlled long term via intrathecal administration of a non-viral vector (NVV) encoding the anti-inflammatory cytokine Interleukin-10 (IL-10) (2004) (6)
CHAPTER 18 – Neuroimmune Interactions and Pain: The Role of Immune and Glial Cells (2007) (6)
Indwelling supradural catheters for induction of facial allodynia: surgical procedures, application of inflammatory stimuli, and behavioral testing. (2012) (5)
Macrophage stimulation reduces the cholesterol levels of stressed and unstressed rats. (1996) (5)
Control vs. lack of control over aversive stimuli: nonopioid-opioid analgesic consequences. (1986) (5)
Evidence for a role of heat shock protein-90 (HSP90) in TLR4 mediated pain enhancement in rats (2009) (5)
Glia: a Novel Drug Discovery Target for Glia: a Novel Drug Discovery Target for Clinical Pain Clinical Pain (2003) (5)
Unilateral T13 and L1 dorsal root avulsion: methods for a novel model of central neuropathic pain. (2012) (5)
Novel toll like receptor 4 (TLR4) involvement in drug reward (2011) (4)
Consequences of the Inflamed Brain (2012) (4)
Proinflammatory cytokines and specific immune function (1996) (4)
Serum cholesterol levels and stressor controllability in rats (2003) (4)
Preconditioning by voluntary wheel running attenuates later neuropathic pain via Nrf2 antioxidant signaling in rats. (2022) (4)
The effects of a single session of inescapable tailshock on the subsequent locomotor response to brief footshock and cocaine administration in rats (2007) (4)
Preconditioning by voluntary wheel running attenuates later neuropathic pain via Nrf2 antioxidant signaling in rats (2021) (4)
Acute stress induces the rapid and transient induction of caspase-1, gasdermin D and release of constitutive IL-1β protein in dorsal hippocampus (2020) (4)
Peripheral beta-adrenoreceptors and stress-induced hypercholesterolemia in rats. (1996) (4)
Inescapable shock-induced potentiation of morphine analgesia in rats: sites of action. (1999) (4)
Constriction of the buccal branch of the facial nerve produces unilateral craniofacial allodynia (2017) (3)
7. The role of microglia in stress-induced depression (2014) (3)
The behavioral and neurochemical effects of an inescapable stressor are time of day dependent (2019) (3)
Selective manipulation of spinal microglia by chemogenetics: Implications for allodynia and inflammatory signaling (2015) (3)
Opiate antagonists and long-term analgesic reaction induced by inescapable shock in rats F. Maier, S. Davies, J.W. Grau, R.L. Jackson, D.H. Morrison, T. Moye, J. Madden, IV and J.D. Barchas, J. comp. physiol. Psychol., 94 (1980) 1172–1183 (1981) (3)
39. Cytokines, antiphospholipids, and cognition in nonNPSLE (2008) (2)
Maternal care modulation of neonatal infection-facilitated cognitive impairment in adulthood (2006) (2)
The role of the medial prefrontal cortex in mediating resistance and vulnerability to the impact of adverse events (2009) (2)
Cytokines and the Brain 2. A Satellite Symposium to the Society for Neuroscience (30th) Annual Meeting Held in New Orleans, Louisiana on November 2-4, 2000 (2000) (2)
Alzheimer's Disease: Protective Effects of Mycobacterium vaccae, a Soil-Derived Mycobacterium with Anti-Inflammatory and Anti-Tubercular Properties, on the Proteomic Profiles of Plasma and Cerebrospinal Fluid in Rats. (2020) (2)
( 1 )-Naloxone , an Opioid-Inactive Toll-Like Receptor 4 Signaling Inhibitor , ReversesMultipleModels of Chronic Neuropathic Pain in Rats (2012) (2)
Endogenous pain facilitory systemsnext term Antianalgesia and hyperalgesia (1992) (2)
12. Rats infected early in life with bacteria exhibit exaggerated fever, sickness behavior, and lack of endotoxin tolerance in adulthood (2008) (2)
259. Plasmid DNA Encoding the Anti-Inflammatory Cytokine Gene, Interleukin-10 (IL-10) for Chronic Pain Control: Taking Advantage of Nuclear Scaffold/Matrix Attachment Regions* (2006) (2)
Elevated prefrontal dopamine interferes with the stress-buffering properties of behavioral control in female rats (2022) (2)
Cholecystokinin Antianalgesia: Safety Cues Abolish Morphine Analgesia (1992) (2)
Antianalgesia and Hyperalgesia (1992) (1)
644. Gene Delivery for Chronic Pain Control: Micrcroencapsulated Plasmid DNA Encoding the Anti-Inflammatory Cytokine Gene, Interleukin-10 (IL-10) (2005) (1)
No . 1 MAY 1967 FAILURE TO ESCAPE TRAUMATIC SHOCK (2005) (1)
Controllable stress elicits circuit-specific patterns of prefrontal plasticity in males, but not females (2019) (1)
Immunization with a heat-killed preparation of Mycobacterium vaccae NCTC 11659 enhances auditory-cued fear extinction in a stress-dependent manner (2022) (1)
Research report The long term acute phase-like responses that follow acute stressor exposure are blocked by alpha-melanocyte stimulating hormone (1998) (1)
Hemocyanin In Vivo Antibody Response Regulatory Role in the Anti-Keyhole Limpet Endogenous Glucocorticoids Play a Positive (2001) (1)
Comparing the effects of two different strains of Mycobacterium vaccae , M. vaccae NCTC 11659 and M. vaccae ATCC 15483, on stress-resilient behaviors and lipid-immune signaling in rats (2020) (1)
Author response: A robust activity marking system for exploring active neuronal ensembles (2016) (1)
Involvement of TLR2–TLR4, NLRP3, and IL-17 in pain induced by a novel Sprague-Dawley rat model of experimental autoimmune encephalomyelitis (2022) (1)
(250) Selective manipulation of spinal microglia by chemogenetics: implications for allodynia and inflammatory signaling (2015) (1)
Novel approaches to control paclitaxel-induced neuropathic pain: Efficacy of interleukin-10 gene therapy and the blood–brain barrier permeable glial modulator, AV411 (2006) (1)
Stressor Controllability and Immune Function (1986) (1)
Long-term stress-induced analgesia blocked by scopolamine (2004) (1)
Learned Helplessness: Event Covariation and Cognitive Changes (2019) (1)
Evidence that tricyclic small molecules may possess Toll-like receptor and MD-2 activity (2010) (1)
(623): Spinal cord gene transfer using naked plasmid DNA coding the anti-inflammatory gene, Interleukin-10 (IL10) leads to long-term reversal of thermal hyperalgesia in chronic constriction injury (CCI) rats (2006) (1)
Sciatic Inflammatory Neuropathy in the Rat (2004) (1)
(464) Prior voluntary wheel running is protective for neuropathic-like pain. (2016) (1)
Stressor Con trollability, An xiety, an d Seroton in (1998) (1)
MODELS BASED ON THE LEARNED HELPLESSNESS HYPOTHESIS (1992) (0)
The Role of Glucocorticoids and Neuroinflammation in Mediating the Effects of Stress on Drug Abuse (2013) (0)
CO2, Ed Board (2014) (0)
218. Elevated hippocampal corticosterone levels may be responsible for sensitizing microglia of healthy aged rats (2011) (0)
CO2, Ed Board (2013) (0)
Selective TLR4 Antagonism Prevents and Reverses Morphine-Induced Persistent Postoperative Cognitive Dysfunction, Dysregulation of Synaptic Elements, and Impaired BDNF Signaling in Aged Male Rats (2022) (0)
Abstract # 3188 Spinal cord injury perturbs circadian rhythms (2019) (0)
CO2, Ed Board (2012) (0)
The interaction effects of surgery and morphine treatment on neuroinflammation and cognitive function in aged rats (2015) (0)
Adenosine 2A receptor agonist produces long-duration reversal of neuropathic pain via sustained release of spinal interleukin-10 (2009) (0)
Current Issues in Animal Learning. A Colloquium, James H. Reynierse (Ed.). University of Nebraska Press, Lincoln (1970) (1972) (0)
CO2, Ed Board (2015) (0)
CO2, Ed Board (2017) (0)
B. Systems (physiology, anatomy, animal models)Animal Models of Chronic Pain: Gene Therapy using naked plasmid DNA coding the anti-inflammatory gene, Interleukin-10 (IL10): repeated injections lead to long-term pain control in chronic constriction injury (CCI) rats (2004) (0)
170. Characterization of the neuroendocrine system in healthy aged rats (2012) (0)
CO1, changing art (2015) (0)
CO2, Editorial Board (2017) (0)
Post-surgical morphine prolongs hippocampal dysfunction in aged rats: Implications for neuroinflammation and neuronal structure (2021) (0)
Peripheral inflammation sensitizes dorsal spinal cord glia: Enhanced glial responsiveness & pain facilitation (2005) (0)
CO2, Ed Board (2011) (0)
CO2, Editorial Board (2017) (0)
The Other "Brain Boosters". (2003) (0)
Editorial Board (2018) (0)
#5 Differences in IL1β expression in brain and periphery between young and aging rats 2h to 2 week following an ip E. coli injection (2005) (0)
Editorial Board (2018) (0)
Abstract # 2044 Glucocorticoids mediate stress-induced upregulation of the alarmin HMGB1 and downregulation of the inhibitory receptor CD200R1 in hippocampus and amygdala: A mechanism of neuroinflammatory priming (2019) (0)
Journal of Experimental Psychology Failure to Escape Traumatic Shock (2010) (0)
55. The role of the liver in E. coli-induced memory impairments in aged rats (2013) (0)
CO2, Ed Board (2013) (0)
210. Rethinking CNS innate immune responses: Sex, pain and drugs of abuse (2011) (0)
CO2, Ed Board (2011) (0)
CO2, Ed Board (2012) (0)
CO2, Ed Board (2015) (0)
CO1, changing art (2016) (0)
Pro-inflammatory signaling in endothelial cells and oligodendrocytes: new players in chronic pain and dysregulation of opioid efficacy (2010) (0)
CO2, Ed Board (2015) (0)
OpioidActivationofToll-LikeReceptor4Contributesto DrugReinforcement (2012) (0)
#42 Uncontrollable stress potentiates hippocampal microglia responses to lipopolysaccharide ex vivo (2005) (0)
CO2, Ed Board (2013) (0)
Editorial Board (2014) (0)
CO2, Editorial Board (2016) (0)
Coping and Immune Function (1991) (0)
#75 IL-1β-induced reduction in spinal cord GRK2 as an underlying mechanism for chronic, inflammatory hyperalgesia (2005) (0)
CO2, Editorial Board (2016) (0)
43. The role of dynamic microglial alterations in stress-induced depression and suppressed neurogenesis (2013) (0)
CO2, Ed Board (2013) (0)
CO2, Ed Board (2011) (0)
TLR4 antagonism ameliorates persistent post-operative cognitive decline (2021) (0)
Monoamine and metabolite content in the rat brain during the estrous cycle pregnancy and postpartum (1987) (0)
Contents of Volume 28 (1987) (0)
CO2, Ed Board (2011) (0)
CO2, Ed Board (2011) (0)
CO1, changing art (2017) (0)
From helplessness to controllability: toward a neuroscience of resilience (2023) (0)
CO2, Ed Board (2014) (0)
(299) Therapeutic morphine prolongs neuropathic pain in Fischer 344 rats: a role for TLR4 and inflammasome signaling in the lumbar spinal cord (2014) (0)
CO2, Ed Board (2012) (0)
Exploring the immunogenic properties of SARS-CoV-2 structural proteins: PAMP:TLR signaling in the mediation of the neuroinflammatory and neurologic sequelae of COVID-19 (2023) (0)
CO2, Ed Board (2014) (0)
The expression of escape deficits produced by uncontrollable stress are mediated by 5-HT 2C receptors in the dorsal striatum (2010) (0)
Diminished circadian rhythms in microglia may contribute to age-related neuroinflammatory sensitization (2015) (0)
CO2, Editorial Board (2016) (0)
CO2, Editorial Board (2016) (0)
CO2, Ed Board (2013) (0)
Commentary on the commentaries (1992) (0)
9. The effects of voluntary wheel running on infection-induced memory deficits and hippocampal BDNF mRNA in aging rats (2009) (0)
CO2, Editorial Board (2017) (0)
31. Therapeutic morphine prolongs neuropathic pain in rats: A role for TLR4 and inflammasome signaling in the lumbar spinal cord (2014) (0)
18. Repeated morphine enhances peripheral nerve injury-induced allodynia via central immune mechanisms (2013) (0)
(624): Polymer-based spinal cord gene transfer of plasmid DNA encoding the anti-inflammatory cytokine, interleukin-10 (IL-10) controls chronic neuropathic pain in rats (2006) (0)
CO2, Ed Board (2012) (0)
80. Long-duration reversal of neuropathic pain via sustained release of spinal interleukin-10 is mediated by adenosine 2A receptor activation (2009) (0)
530. Spinal interleukin-10 (IL-10) gene therapy using viral and non-viral vectors controls inflammatory- and chronic constriction injury-induced pain states in rats (2004) (0)
Abstract # 3170 The TLR2/4 antagonist (+)-naltrexone blocks contextual long-term memory deficits in experimental autoimmune encephalitis and associated neuroinflammation in hippocampus (2019) (0)
CO2, Ed Board (2018) (0)
(330/619): AV411, a blood-brain barrier permeable glial inhibitor, attenuates chronic constriction injury (CCI)- and paclitaxel-induced neuropathic pain (2006) (0)
#130 Prior peripheral challenge may exacerbate later immune responses (2005) (0)
CO2, Ed Board (2013) (0)
CO2, Ed Board (2011) (0)
Abstract # 3175 Mycobacterium vaccae immunization protects aged rats from surgery-elicited neuroinflammation and cognitive dysfunction (2019) (0)
Animal memory and cognition (1987) (0)
CO2, Ed Board (2017) (0)
Editorial Board (2018) (0)
Responding to the Challenges of the Environment: Stressors, the Brain, and Work (2011) (0)
Short communication Subdiaphragmatic vagotomy blocks interleukin-1b-induced fever but does not reduce IL-1b levels in the circulation (2000) (0)
AWARD NUMBER: W81XWH-12-1-0345 PROJECT TITLE: Combating drug abuse by targeting toll-like receptor 4 (TLR) PRINCIPAL INVESTIGATOR: Dr. Linda Watkins CONTRACTING ORGANIZATION: University of Colorado, Boulder (2016) (0)
Combating Drug Abuse by Targeting Toll-Like Receptor 4 (TLR4) (2014) (0)
CO2, Ed Board (2014) (0)
38. Anti-NMDA receptor antibodies and cognition in nonNPSLE (2008) (0)
CO2, Editorial Board (2016) (0)
CO2, Ed Board (2013) (0)
CO2, Ed Board (2012) (0)
CO2, Ed Board (2011) (0)
Editorial Board (2018) (0)
CO2, Editorial Board (2015) (0)
CO2, Ed Board (2013) (0)

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