Steven G. Younkin

Steven G. Younkin's AcademicInfluence.com Rankings

Steven G. Younkin

Law

#2195

World Rank

#2754

Historical Rank

Common Law

#73

World Rank

#81

Historical Rank

law Degrees

Steven G. Younkin

Biology

#7404

World Rank

#10324

Historical Rank

Neuroscience

#960

World Rank

#1000

Historical Rank

biology Degrees

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Biology

Steven G. Younkin's Degrees

Doctorate Medicine Johns Hopkins University

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Steven G. Younkin's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice (1996) (4216)
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease (2013) (3484)
Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease (1996) (2328)
TREM2 variants in Alzheimer's disease. (2013) (2173)
Common variants in ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer’s disease (2011) (1701)
Common variants in MS4A4/MS4A6E, CD2uAP, CD33, and EPHA1 are associated with late-onset Alzheimer’s disease (2011) (1656)
Letter abstract - Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's Disease (2009) (1644)
Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1 (1996) (1502)
Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo (1996) (1492)
An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants. (1994) (1479)
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease, and shows evidence for additional susceptibility genes (2009) (1441)
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes (1998) (1400)
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease (2013) (1388)
Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease (2014) (1230)
Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase (2004) (1213)
Genome-wide analysis of genetic loci associated with Alzheimer disease. (2010) (1177)
The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Aβ protofibril formation (2001) (1135)
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease (2007) (1112)
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (2019) (1073)
Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice (1999) (960)
Release of excess amyloid beta protein from a mutant amyloid beta protein precursor. (1993) (921)
Age-Dependent Changes in Brain, CSF, and Plasma Amyloid β Protein in the Tg2576 Transgenic Mouse Model of Alzheimer's Disease (2001) (904)
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. (1996) (884)
Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase. (2004) (787)
Processing of the amyloid protein precursor to potentially amyloidogenic derivatives. (1992) (695)
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease (2017) (693)
The Relationship between Aβ and Memory in the Tg2576 Mouse Model of Alzheimer's Disease (2002) (645)
Genetic Evidence Implicates the Immune System and Cholesterol Metabolism in the Aetiology of Alzheimer's Disease (2010) (587)
Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins (1995) (551)
BACE1 Deficiency Rescues Memory Deficits and Cholinergic Dysfunction in a Mouse Model of Alzheimer's Disease (2004) (538)
Environmental Enrichment Mitigates Cognitive Deficits in a Mouse Model of Alzheimer's Disease (2005) (495)
Alzheimery's disease pathology is associated with early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci (2014) (482)
Amyloid beta protein (A beta) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43). (1995) (455)
Reversible Memory Loss in a Mouse Transgenic Model of Alzheimer's Disease (2002) (440)
Expression of β amyloid protein precursor mRNAs: Recognition of a novel alternatively spliced form and quantitation in alzheimer's disease using PCR (1990) (426)
Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease. (2001) (412)
Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci (2014) (402)
SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein (1999) (395)
Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. (2000) (389)
Cholesterol-Dependent γ-Secretase Activity in Buoyant Cholesterol-Rich Membrane Microdomains (2002) (386)
Association of Low Plasma Aβ42/Aβ40 Ratios With Increased Imminent Risk for Mild Cognitive Impairment and Alzheimer Disease (2007) (373)
Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)* (2015) (362)
Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members (2009) (348)
The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease. (2002) (326)
18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease (2009) (326)
Evidence that Aβ42 is the real culprit in alzheimer's disease (1995) (317)
Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein (2008) (311)
TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson’s disease (2013) (311)
Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis (2012) (308)
Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease (2009) (299)
Evidence for glial-mediated inflammation in aged APPSW transgenic mice (1999) (297)
Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias (2014) (295)
Dimeric Amyloid β Protein Rapidly Accumulates in Lipid Rafts followed by Apolipoprotein E and Phosphorylated Tau Accumulation in the Tg2576 Mouse Model of Alzheimer's Disease (2004) (295)
Cerebrovascular autoregulation is profoundly impaired in mice overexpressing amyloid precursor protein. (2002) (277)
Common variants at MS 4 A 4 / MS 4 A 6 E , CD 2 AP , CD 33 and EPHA 1 are associated with late-onset Alzheimer ’ s disease (2011) (274)
Human whole genome genotype and transcriptome data for Alzheimer’s and other neurodegenerative diseases (2016) (266)
APP Processing and Synaptic Plasticity in Presenilin-1 Conditional Knockout Mice (2001) (251)
Association of plasma beta-amyloid level and cognitive reserve with subsequent cognitive decline. (2011) (250)
Biochemical detection of Aβ isoforms: implications for pathogenesis, diagnosis, and treatment of Alzheimer’s disease (2000) (249)
Amyloid protein precursor messenger RNAs: differential expression in Alzheimer's disease. (1988) (245)
The role of Aβ42 in Alzheimer's disease (1998) (243)
Abeta 1-40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation. (2000) (242)
A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43). (1997) (242)
Brain Expression Genome-Wide Association Study (eGWAS) Identifies Human Disease-Associated Variants (2012) (232)
Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides. (1993) (231)
NADPH Oxidase-Derived Reactive Oxygen Species Mediate the Cerebrovascular Dysfunction Induced by the Amyloid β Peptide (2005) (231)
Replication of CLU, CR1, and PICALM associations with alzheimer disease. (2010) (221)
Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity. (2008) (216)
The beta-amyloid protein precursor of Alzheimer disease has soluble derivatives found in human brain and cerebrospinal fluid. (1989) (216)
Amyloid β Protein (Aβ) in Alzheimeri's Disease Brain (1995) (210)
Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains. (2002) (207)
Increased Susceptibility to Ischemic Brain Damage in Transgenic Mice Overexpressing the Amyloid Precursor Protein (1997) (204)
Biochemical markers in persons with preclinical familial Alzheimer disease (2008) (204)
Persistent Amyloidosis following Suppression of Aβ Production in a Transgenic Model of Alzheimer Disease (2005) (203)
Association of low plasma Abeta42/Abeta40 ratios with increased imminent risk for mild cognitive impairment and Alzheimer disease. (2007) (202)
Alterations in Cerebral Blood Flow and Glucose Utilization in Mice Overexpressing the Amyloid Precursor Protein (2002) (198)
Tau Loss Attenuates Neuronal Network Hyperexcitability in Mouse and Drosophila Genetic Models of Epilepsy (2013) (196)
Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study (2019) (194)
The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice (2004) (190)
Acetylcholinesterase promotes beta-amyloid plaques in cerebral cortex (2003) (184)
In situ hybridization of nucleus basalis neurons shows increased beta-amyloid mRNA in Alzheimer disease. (1988) (177)
Amyloid β protein (Aβ) removal by neuroglial cells in culture (1995) (177)
Convergent genetic and expression data implicate immunity in Alzheimer's disease (2014) (172)
Genetic modification of the phenotypes produced by amyloid precursor protein overexpression in transgenic mice. (1997) (172)
Amyloid β protein starting pyroglutamate at position 3 is a major component of the amyloid deposits in the Alzheimer's disease brain (2000) (170)
Amyloids and Are Generated Intracellularly in Cultured Human Neurons and Their Secretion Increases with Maturation (*) (1996) (169)
Ataxin-2 repeat-length variation and neurodegeneration. (2011) (164)
Meta-analysis of the association between variants in SORL1 and Alzheimer disease. (2011) (159)
Reduced effectiveness of Aβ1-42 immunization in APP transgenic mice with significant amyloid deposition (2001) (158)
Cellular localization of the molecular forms of acetylcholinesterase in rat diaphragm. (1982) (158)
Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy (2015) (157)
Novel late-onset Alzheimer disease loci variants associate with brain gene expression (2012) (155)
Transethnic genome-wide scan identifies novel Alzheimer's disease loci (2017) (149)
Astrocytes in Alzheimer's disease gray matter express alpha 1-antichymotrypsin mRNA. (1989) (141)
Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. (2014) (140)
Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's disease. (2004) (135)
Altered metabolism of familial Alzheimer's disease-linked amyloid precursor protein variants in yeast artificial chromosome transgenic mice. (1997) (134)
An Alzheimer's Disease-Linked PS1 Variant Rescues the Developmental Abnormalities of PS1-Deficient Embryos (1998) (129)
Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma. (2010) (129)
Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid-β (2011) (123)
TREM2 Variants in Alz hei mer's Disease (2012) (118)
Brain Perivascular Macrophages Initiate the Neurovascular Dysfunction of Alzheimer A&bgr; Peptides (2017) (117)
APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids (2020) (115)
Differences in the Aβ40/Aβ42 ratio associated with cerebrospinal fluid lipoproteins as a function of apolipoprotein E genotype (2000) (115)
Involvement of β-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity (2007) (115)
APOE &egr;4/&egr;4 diminishes neurotrophic function of human iPSC-derived astrocytes (2017) (115)
Rodent Aβ Modulates the Solubility and Distribution of Amyloid Deposits in Transgenic Mice* (2007) (113)
Innate immunity receptor CD36 promotes cerebral amyloid angiopathy (2013) (113)
Increased Aβ42(43) from cell lines expressing presenilin 1 mutations (1998) (112)
Secretory processing of the Alzheimer amyloid beta/A4 protein precursor is increased by protein phosphorylation. (1992) (110)
The role of A beta 42 in Alzheimer's disease. (1998) (106)
BRI2 (ITM2b) Inhibits Aβ Deposition In Vivo (2008) (105)
ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer's Neuronal Pathology (2016) (104)
A Presenilin 1 Mutation Associated with Familial Frontotemporal Dementia Inhibits γ-Secretase Cleavage of APP and Notch (2002) (103)
Additive Effects of PS1 and APP Mutations on Secretion of the 42-Residue Amyloid β-Protein (1998) (101)
Association of MAPT haplotypes with Alzheimer’s disease risk and MAPT brain gene expression levels (2014) (100)
Genetic variants in a haplotype block spanning IDE are significantly associated with plasma Aβ42 levels and risk for Alzheimer disease (2004) (99)
Biochemical detection of Abeta isoforms: implications for pathogenesis, diagnosis, and treatment of Alzheimer's disease. (2000) (97)
Conserved brain myelination networks are altered in Alzheimer's and other neurodegenerative diseases (2018) (96)
Amyloid β protein levels in cerebrospinal fluid are elevated in early‐onset Alzheimer's disease (1994) (95)
Genome-wide association analysis of age-at-onset in Alzheimer's disease (2012) (93)
Systematic analysis of dark and camouflaged genes reveals disease-relevant genes hiding in plain sight (2019) (92)
Late-onset Alzheimer’s risk variants in memory decline, incident mild cognitive impairment, and Alzheimer’s disease (2015) (92)
Evidence that A beta 42 is the real culprit in Alzheimer's disease. (1995) (92)
Plasma amyloid-β and risk of Alzheimer's disease in the Framingham Heart Study (2015) (89)
Twofold overexpression of human β‐amyloid precursor proteins in transgenic mice does not affect the neuromotor, cognitive, or neurodegenerative sequelae following experimental brain injury (1998) (89)
Flemish and Dutch Mutations in Amyloid β Precursor Protein Have Different Effects on Amyloid β Secretion (1998) (87)
Substances moved by axonal transport and released by nerve stimulation have an innervation-like effect on muscle. (1978) (86)
Decreased neprilysin immunoreactivity in Alzheimer disease, but not in pathological aging. (2005) (82)
TMEM106B risk variant is implicated in the pathologic presentation of Alzheimer disease (2012) (81)
Genetic background regulates β-amyloid precursor protein processing and β-amyloid deposition in the mouse (2003) (80)
Neuronal Expression of β-Amyloid Precursor Protein Alzheimer Mutations Causes Intracellular Accumulation of a C-terminal Fragment Containing Both the Amyloid β and Cytoplasmic Domains* (1997) (78)
Soluble derivatives of the β amyloid protein precursor of Alzheimer's disease are labeled by antisera to the β amyloid protein (1989) (78)
Amyloids beta40 and beta42 are generated intracellularly in cultured human neurons and their secretion increases with maturation. (1996) (77)
Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications (2012) (75)
Antisera to an amino-terminal peptide detect the amyloid protein precursor of Alzheimer's disease and recognize senile plaques. (1988) (72)
Detection of soluble forms of the β-amyloid precursor protein in human plasma (1990) (72)
An analysis of the role of calcium in facilitation at the frog neuromuscular junction (1974) (71)
Serum creatinine levels correlate with plasma amyloid β protein (2002) (71)
THE ROLE OF ABETA 42 IN ALZHEIMER'S DISEASE (1998) (70)
Amyloid beta protein (A beta) removal by neuroglial cells in culture. (1995) (68)
Selective increase in cellular Aβ42 is related to apoptosis but not necrosis (2000) (67)
TYROBP genetic variants in early-onset Alzheimer's disease (2016) (67)
The Alternatively Spliced Kunitz Protease Inhibitor Domain Alters Amyloid β Protein Precursor Processing and Amyloid β Protein Production in Cultured Cells* (1996) (66)
Replication of EPHA1 and CD33 associations with late-onset Alzheimer's disease: a multi-centre case-control study (2011) (66)
Replication of BIN1 association with Alzheimer's disease and evaluation of genetic interactions. (2011) (66)
Molecular forms of acetylcholinesterases in Alzheimer's disease. (1986) (65)
High levels of circulating β-amyloid peptide do not cause cerebral β-amyloidosis in transgenic mice (1996) (65)
Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease (2009) (64)
Investigation of 15 of the top candidate genes for late-onset Alzheimer’s disease (2010) (63)
Elevated amyloid beta protein (Abeta42) and late onset Alzheimer's disease are associated with single nucleotide polymorphisms in the urokinase-type plasminogen activator gene. (2005) (63)
Accumulation of β-Amyloid fibrils in pancreas of transgenic mice (1996) (63)
Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer’s disease resilience (2017) (61)
The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease. (2012) (61)
Late-onset Alzheimer disease risk variants mark brain regulatory loci (2015) (60)
Genetics of CD33 in Alzheimer's disease and acute myeloid leukemia. (2015) (60)
Molecular biology of Alzheimer's disease. (1993) (59)
Brain Aβ amyloidosis in APPsw mice induces accumulation of presenilin‐1 and tau (2001) (59)
Genetic background regulates beta-amyloid precursor protein processing and beta-amyloid deposition in the mouse. (2003) (58)
Spatial and temporal features of afferent inhibition of thalamocortical relay cells. (1979) (58)
Expression of SORL1 and a novel SORL1 splice variant in normal and Alzheimers disease brain (2009) (58)
Genetic variants influencing human aging from late-onset Alzheimer's disease (LOAD) genome-wide association studies (GWAS) (2012) (57)
Memory deficits correlating with acetylcholinesterase splice shift and amyloid burden in doubly transgenic mice. (2005) (57)
Association of common KIBRA variants with episodic memory and AD risk (2011) (55)
Plasma amyloid beta protein is elevated in late-onset Alzheimer disease families. (2008) (55)
Shared genetic contribution to ischemic stroke and Alzheimer's disease (2016) (55)
Heritability of plasma amyloid β in typical late‐onset Alzheimer’s disease pedigrees (2001) (54)
Expression and processing analyses of wild type and p.R47H TREM2 variant in Alzheimer’s disease brains (2016) (53)
Differences in the Abeta40/Abeta42 ratio associated with cerebrospinal fluid lipoproteins as a function of apolipoprotein E genotype. (2000) (52)
C9ORF72 repeat expansions and other FTD gene mutations in a clinical AD patient series from Mayo Clinic. (2012) (52)
Age-Dependent Changes in Brain , CSF , and Plasma Amyloid b Protein in the Tg 2576 Transgenic Mouse Model of Alzheimer ’ s Disease (2001) (50)
Alzheimer's amyloid precursor protein produced by recombinant baculovirus expression. Proteolytic processing and protease inhibitory properties. (1991) (49)
Presenilins as therapeutic targets for the treatment of Alzheimer's disease. (2001) (48)
A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression (2016) (47)
Glycosylphosphatidylinositol-anchored Proteins Play an Important Role in the Biogenesis of the Alzheimer’s Amyloid β-Protein* (1999) (47)
Co-expression of β-amyloid precursor protein (βAPP) and apolipoprotein E in cell culture: analysis of βAPP processing (1995) (47)
Late-onset Alzheimer disease genetic variants in posterior cortical atrophy and posterior AD (2014) (47)
Effect of denervation on the molecular forms of acetylcholinesterase in rat diaphragm. (1982) (45)
Serum Creatinine Levels Correlate With Plasma Amyloid &bgr; Protein (2002) (44)
Evaluation of memory endophenotypes for association with CLU, CR1, and PICALM variants in black and white subjects (2014) (44)
ApoE variant p.V236E is associated with markedly reduced risk of Alzheimer’s disease (2014) (44)
Increased aggression in males in transgenic Tg2576 mouse model of Alzheimer's disease (2011) (44)
Neurotrophic regulation of resting membrane potential and acetylcholine sensitivity in rat extensor digitorum longus muscle (1977) (44)
Gene expression, methylation and neuropathology correlations at progressive supranuclear palsy risk loci (2016) (43)
Decreased level of brain acetylcholine and memory disturbance in APPsw mice (2004) (43)
A multi-center study of ACE and the risk of late-onset Alzheimer's disease. (2011) (42)
High throughput screens for the identification of compounds that alter the accumulation of the Alzheimer's amyloid β peptide (Aβ) (2001) (42)
Cellular localization of the molecular forms of acetylcholinesterase in cultured embryonic rat myotubes (1982) (41)
Divergent brain gene expression patterns associate with distinct cell-specific tau neuropathology traits in progressive supranuclear palsy (2018) (41)
Effect of nerve stump length on cholinesterase in denervated rat diaphragm (1978) (40)
Altered Amyloid-β Metabolism and Deposition in Genomic-based β-Secretase Transgenic Mice* (2004) (40)
TLR5 decoy receptor as a novel anti-amyloid therapeutic for Alzheimer’s disease (2018) (39)
Rarity of the Alzheimer disease-protective APP A673T variant in the United States. (2015) (39)
Plasmin deficiency does not alter endogenous murine amyloid beta levels in mice (2004) (39)
Assembly of monomeric acetylcholinesterase into tetrameric and asymmetric forms. (1986) (38)
Accelerated degradation of junctional acetylcholine receptor-α-bungarotoxin complexes in denervated rat diaphragm (1982) (34)
Soluble derivatives of the beta amyloid protein precursor in cerebrospinal fluid: alterations in normal aging and in Alzheimer's disease. (1990) (34)
Uncoupling of endothelial nitric oxide synthase in cerebral vasculature of Tg2576 mice (2015) (32)
Normal Processing of the Alzheimer's Disease Amyloid β Protein Precursor Generates Potentially Amyloidogenic Carboxyl‐Terminal Derivatives (1992) (32)
High levels of circulating beta-amyloid peptide do not cause cerebral beta-amyloidosis in transgenic mice. (1996) (31)
Amyloid β vaccination: reduced plaques and improved cognition (2001) (31)
Hereditary cerebral hemorrhage with amyloidosis dutch type (AβPP 693): decreased plasma amyloid-β 42 concentration (2003) (29)
The effect of spontaneous electromechanical activity on the metabolism of acetylcholinesterase in cultured embryonic rat myotubes (1984) (28)
Bosentan preserves endothelial function in mice overexpressing APP (2006) (28)
Plasma Levels of Aβ42 and Aβ40 in Alzheimer Patients during Treatment with the Acetylcholinesterase Inhibitor Tacrine (2002) (28)
Whole exome sequence-based association analyses of plasma amyloid-β in African and European Americans; the Atherosclerosis Risk in Communities-Neurocognitive Study (2017) (28)
In situ hybridization of nucleus basalis neurons shows increased β-amyloid mRNA in Alzheimerʼs disease (1988) (27)
APOE3-Jacksonville (V236E) variant reduces self-aggregation and risk of dementia (2021) (26)
Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (2019) (26)
Activation of PPARδ prevents endothelial dysfunction induced by overexpression of amyloid-β precursor protein. (2012) (26)
Co-expression of beta-amyloid precursor protein (betaAPP) and apolipoprotein E in cell culture: analysis of betaAPP processing. (1995) (25)
Association and heterogeneity at the GAPDH locus in Alzheimer's disease (2012) (25)
Characterization by radiosequencing of the carboxyl-terminal derivatives produced from normal and mutant amyloid β protein precursors (1994) (25)
Identification of loci determining susceptibility to the lethal effects of amyloid precursor protein transgene overexpression. (2004) (25)
The amyloid beta protein precursor mutations linked to familial Alzheimer's disease alter processing in a way that fosters amyloid deposition. (1994) (24)
Network-driven plasma proteomics expose molecular changes in the Alzheimer’s brain (2016) (24)
Meta-analysis of the Association Between Variants in SORL 1 and Alzheimer Disease (2011) (23)
African American exome sequencing identifies potential risk variants at Alzheimer disease loci (2017) (23)
MAPT haplotype diversity in multiple system atrophy. (2016) (23)
Hereditary cerebral hemorrhage with amyloidosis Dutch type (AbetaPP 693): decreased plasma amyloid-beta 42 concentration. (2003) (23)
THE β AMYLOID PROTEIN PRECURSOR OF ALZHEIMERʼS DISEASE HAS SOLUBLE DERIVATIVES FOUND IN HUMAN BRAIN AND CEREBROSPINAL FLUID: 231 (1989) (22)
Amyloid beta protein levels in cerebrospinal fluid are elevated in early-onset Alzheimer's disease. (1994) (21)
Selective increase in cellular A beta 42 is related to apoptosis but not necrosis. (2000) (20)
Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer’s disease (2018) (20)
The alternatively spliced Kunitz protease inhibitor domain alters amyloid beta protein precursor processing and amyloid beta protein production in cultured cells. (1996) (20)
Using peptide nucleic acids as gene-expression modifiers to reduce β-amyloid levels (2002) (19)
Truncated presenilin 2 derived from differentially spliced mRNAs does not affect the ratio of amyloid β‐peptide 1‐42/1‐40 (1998) (19)
MOLECULAR FORMS OF ACETYLCHOLINESTERASE IN ALZHEIMERʼS DISEASE (1986) (19)
Amyloid beta vaccination: reduced plaques and improved cognition. (2001) (19)
Type-specific evolution of amyloid plaque and angiopathy in APPsw mice (2006) (17)
Evaluating pathogenic dementia variants in posterior cortical atrophy (2016) (17)
Accumulation of beta-amyloid fibrils in pancreas of transgenic mice. (1996) (17)
Linking Protective GAB2 Variants, Increased Cortical GAB2 Expression and Decreased Alzheimer’s Disease Pathology (2013) (16)
High throughput screens for the identification of compounds that alter the accumulation of the Alzheimer's amyloid beta peptide (Abeta). (2001) (16)
Evaluation of the global association between cholesterol-associated polymorphisms and Alzheimer's disease suggests a role for rs3846662 and HMGCR splicing in disease risk (2011) (16)
Production of amyloid beta protein from normal amyloid beta-protein precursor (beta APP) and the mutated beta APPS linked to familial Alzheimer's disease. (1993) (15)
An intronic PICALM polymorphism, rs588076, is associated with allelic expression of a PICALM isoform (2014) (15)
Altered amyloid-beta metabolism and deposition in genomic-based beta-secretase transgenic mice. (2004) (14)
Processing of the amyloid β-protein precursor (1995) (14)
Plasma levels of Abeta42 and Abeta40 in Alzheimer patients during treatment with the acetylcholinesterase inhibitor tacrine. (2002) (14)
Plasma amyloid β levels are driven by genetic variants near APOE, BACE1, APP, PSEN2: A genome‐wide association study in over 12,000 non‐demented participants (2021) (12)
Replication of EPHA 1 and CD 33 associations with late-onset Alzheimer ’ s disease : a multi-centre case-control study (2011) (12)
Turnover of acetylcholinesterase in innervated and denervated rat diaphragm. (1984) (12)
Apolipoprotein E regulates lipid metabolism and α-synuclein pathology in human iPSC-derived cerebral organoids (2021) (11)
Systematic analysis of dark and camouflaged genes: disease-relevant genes hiding in plain sight (2019) (11)
Lack of association of hepatic lipase polymorphisms with late-onset Alzheimer's disease (2008) (11)
Plasma beta-amyloid peptide, transforming growth factor-beta 1, and risk for cerebral amyloid angiopathy. (2000) (11)
Role of elevated amyloid β protein in patients with typical late onset Alzheimer's disease (2000) (9)
Investigating statistical epistasis in complex disorders. (2011) (9)
Detection of soluble forms of the beta-amyloid precursor protein in human plasma. (1990) (9)
Neural control of chloride conductance in rat extensor digitorum longus muscle (1978) (7)
Soluble derivatives of the beta amyloid protein precursor of Alzheimer's disease are labeled by antisera to the beta amyloid protein. (1989) (7)
Processing of the Alzheimer's disease beta A4 amyloid protein precursor (APP). (1991) (7)
Evaluation of Associations of Alzheimer's Disease Risk Variants that Are Highly Expressed in Microglia with Neuropathological Outcome Measures. (2019) (7)
[The AAP and PS1/2 mutations linked to early onset familial Alzheimer's disease increase the extracellular concentration and A beta 1-42 (43)]. (1997) (7)
Expression and processing analyses of wild type and p.R47H TREM2 variant in Alzheimer’s disease brains (2016) (7)
Functional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus (2012) (7)
Erratum: Accumulation of β-amyloid fibrils in pancreas of transgenic mice (Neurobiology of Aging (1996) 17 (215-222)) (1996) (6)
Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer’s disease resilience (2017) (6)
P3-011 Analysis of plasma Aβ42 ASA premorbid biomarker for late onset Alzheimer's disease (2004) (6)
Current concepts in alzheimer's disease (2010) (6)
A transient increase in junctional acetylcholine receptors after denervation (1981) (6)
Association study between multiple system atrophy and TREM2 p.R47H (2018) (6)
Association of Midlife Plasma Amyloid-β Levels With Cognitive Impairment in Late Life (2021) (5)
Correction to: Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer’s disease resilience (2018) (5)
Effect of leuprolide on serum amyloid-β peptide levels and memory in patients with prostate cancer with biochemical recurrence. (2013) (5)
Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions (2020) (5)
Activation of PPAR d prevents endothelial dysfunction induced by overexpression of amyloid- b precursor protein (2012) (5)
Alzheimer’s disease and progressive supranuclear palsy share similar transcriptomic changes in distinct brain regions (2021) (5)
Rheumatoid arthritis-associated polymorphisms are not protective against Alzheimer's disease (2011) (4)
Manifestations of Alzheimer’s disease genetic risk in the blood are evident in a multiomic analysis in healthy adults aged 18 to 90 (2022) (4)
Effect of fibrillation on the secretion of acetylcholinesterase from cultured embryonic rat myotubes (1986) (4)
Genome-wide association study of age at onset of Alzheimer's disease (2009) (4)
Peptide nucleic acids targeted to the amyloid precursor protein (2007) (4)
PROCESSING OF NEURONALLY-GENERATED ßAPP BY MACROPHAGES AND MICROGLIA (1993) (4)
Comprehensive Screening for Disease Risk Variants in Early-Onset Alzheimer's Disease Genes in African Americans Identifies Novel PSEN Variants. (2017) (3)
TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson’s disease (2013) (3)
Effect of fibrillation on acetylcholinesterase mRNA in cultured embryonic rat myotubes. (1988) (3)
Multiple Insulin Degrading Enzyme Variants Alter In Vitro Reporter Gene Expression (2011) (3)
DETECTION OF CIRCULATING FORMS OF THE β-AMYLOID PRECURSOR PROTEIN (BAPP) IN HUMAN PLASMA: 230 (1989) (3)
The Arctic APP mutation (E693G) causes Alzheimer's disease through a novel mechanism: Increased amyloid βprotfibril formation and decreased amyloid βlevels in plasma and conditioned media (2000) (3)
Partial purification by vacuum distillation of a factor that increases the junctional acetylcholinesterase of organ cultured rat diaphragm (1982) (3)
149 The Presenilin 1 and 2 mutations linked to familial Alzheimer's Disease increase the extracellular concentration of amyloid 0 protein (Aβ) ending at Aβ42(43) (1996) (3)
Genome-wide exploration of DNA methylation in the aging brain and its relation to Alzheimer's disease (2012) (3)
MORPHOMETRY OF CHOLINERGIC NEURONS IN ALZHEIMERʼS DISEASE (1986) (3)
Environmental enrichment mitigates cognitive deficits in APP/PS1 transgenic mice (2005) (2)
Correction: Genetic Evidence Implicates the Immune System and Cholesterol Metabolism in the Aetiology of Alzheimer's Disease (2011) (2)
Impact of variant-level batch effects on identification of genetic risk factors in large sequencing studies (2020) (2)
Cytokine and Leukocyte Profiling Reveal Pro-Inflammatory and Autoimmune Features in Frontotemporal Dementia Patients (2016) (2)
Erratum to: Network-driven plasma proteomics expose molecular changes in the Alzheimer’s brain (2016) (2)
Blood type gene locus has no influence on ACE association with Alzheimer's disease (2015) (2)
Role of GPI-anchored proteins in β-secretase processing (2000) (2)
87 Hydrogen peroxide treatment induces selective deposition of Aß42(43) in primary neurons of mixed fetal guinea pig brain cultures (1996) (2)
eSNPs within VAMP1 show genetic association with late onset Alzheimer's disease (2010) (1)
The effect of brief exposure of rat sciatic nerve to high concentrations of colchicine (1976) (1)
Identification of novel Alzheimer’s disease genes co-expressed with TREM2 (2020) (1)
Production of Amyloid β Protein from Normal and Mutated Amyloid β Protein Precursors (1994) (1)
An intronic PICALM polymorphism, rs588076, is associated with allelic expression of a PICALMisoform (2014) (1)
Linkage analysis of plasma amyloid β protein in typical late onset Alzheimer disease (load) (2000) (1)
Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer’s disease (2018) (1)
Plasma Aβ40 and Aβ42 in Alzheimer's patients during treatment with tacrine (2000) (1)
Meta-analysis of the association between SORL1 variants and Alzheimer's disease (2010) (1)
Evaluation of Memory Endophenotypes for Association with CLU, CR1 and PICALM variants in African-American and Caucasian Subjects (2014) (1)
Assessing the effect of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism on mRNA transcript levels, Alzheimer’s disease (AD) risk and cognitive performance (P2.163) (2015) (1)
Association of a missense cathepsin D (CTSD) SNP with risk of Alzheimer's disease (2009) (1)
Association of MAPT haplotypes with Alzheimer’s disease risk and MAPT brain gene expression levels (2014) (1)
Genetic association of variants with late-onset Alzheimer's disease risk and brain gene expression (2012) (1)
Mayo and the mouse (2000) (1)
Genome-wide Association Study Links APOEɛ4 and BACE1 Variants with Plasma Amyloid β Levels (2017) (1)
PL-01-02 Genetics (2006) (1)
Conserved Architecture of Brain Transcriptome Changes between Alzheimer’s Disease and Progressive Supranuclear Palsy in Pathologically Affected and Unaffected Regions (2021) (1)
ApoE variant p.V236E is associated with markedly reduced risk of Alzheimer’s disease (2014) (1)
Systematic analysis of dark and camouflaged genes reveals disease-relevant genes hiding in plain sight (2019) (1)
Concordant association of functional IDE variant with IDE mRNA, Aß, and Alzheimer's disease (2009) (0)
STOP-GAIN AND NON-SYNONYMOUS VARIANTS IN NOVEL GENES OF AN IMMUNE CO-REGULATORY NETWORK SHOW STRONG ASSOCIATION WITH ALZHEIMER’S DISEASE (2019) (0)
P3-244: Insulin degrading enzyme and the risk of late-onset Alzheimer's disease: A large replication study in a European population (2008) (0)
Association of glyceraldehyde-3-phosphate dehydrogenase locus variant with late-onset Alzheimer's disease (2010) (0)
the Environment Reaching the Limits of Genome-wide Significance in Alzheimer Disease : Back to (2010) (0)
ANALYSIS OF CEREBROSPINAL FLUID REVEALS THAT SOLUBLE DERIVATIVES OF THE β AMYLOID PROTEIN PRECURSOR ARE ALTERED IN NORMAL AGING AND TO A GREATER EXTENT IN ALZHEIMERʼS DISEASE: 145 (1990) (0)
The ΔNL Alzheimer Mutation (Swedish) Increases Plasma Amyloid B Protein Concentration: 6 (1995) (0)
The plasma Aβ42/Aβ40 ratio: A promising biomarker for cognitive decline (2010) (0)
BLOOD GENE EXPRESSION CHANGES IMPLICATED IN ALZHEIMER’S DISEASE (2016) (0)
Trophic Regulation of Skeletal Muscle Acetylcholinesterase (2020) (0)
Effect of APOE4 Status and Alzheimer's Disease on Posterior Cingulate Connectivity (2010) (0)
Replication of LOAD GWAS Associations (2011) (0)
Association of common KIBRA variants with episodic memory and Alzheimer risk (2010) (0)
P1-310 Late onset Alzheimer’s disease (LOAD) susceptibility alleles in the insulin-degrading-enzyme gene (IDE) and other Aβ-degrading enzymes (2006) (0)
Association study of late-onset Alzheimer's disease risk variants and risk for posterior cortical atrophy (2013) (0)
Oral Sessions: O3-04: Genetics: Transcriptomic and Epigenetic Changes in Alzheimer’s Disease and Related Traits (2014) (0)
Erratum to: Network-driven plasma proteomics expose molecular changes in the Alzheimer’s brain (2016) (0)
Haplotypes at the MAPT locus associate with risk for LOAD and brain gene expression (2013) (0)
An examination of previously reported Alzheimer candidate genes within a large genome-wide association dataset (2009) (0)
Current concepts in Alzheimer's Disease. [Emerging Frontiers in Brain Research: Crossroads of metabolic regulaltion, stress response and disease. The 11th Meeting of Hirosaki International Forum of Medical Science. Communication Center of Hirosaki University School of Medicine. March 27-28,2009. Hir (2010) (0)
POLYGENIC SCORE ANALYSIS OF EXONIC VARIANTS IN AN IMMUNE CO-REGULATORY NETWORK IDENTIFIES NOVEL PROTEIN-ALTERING VARIANTS THAT ASSOCIATE WITH ALZHEIMER’S DISEASE (2018) (0)
Explorer Concordant Association of Insulin Degrading Enzyme Gene ( IDE ) Variants with IDE mRNA , A beta , and Alzheimer ' s Disease (2017) (0)
MAPPING REGULATORY VARIANTS IN THE ALZHEIMER'S DISEASE CANDIDATE GENE ABCA7 (2016) (0)
The genetics of cognitively healthy aging (2012) (0)
A REGULATORY VARIANT AT THE TREM GENE CLUSTER ASSOCIATES WITH DECREASED ALZHEIMER’S DISEASE RISK AND INCREASED TREML1 AND TREM2 BRAIN GENE EXPRESSION (2016) (0)
CONSTRUCTION OF RETROVIRAL VECTORS DESIGNED TO INCREASE EXPRESSION OF THE β AMYLOID PROTEIN AND ITS PRECURSOR: 122 (1989) (0)
ANALYSIS OF WILD TYPE AND R47H MUTANT TREM2 EXPRESSION IN ALZHEIMER'S DISEASE BRAINS (2016) (0)
P2-037 Genetic evidence for therapeutic inhibition of BACE1 in an Alzheimer's mouse model (2004) (0)
O2-06-04: Identification of late-onset Alzheimer's disease (LOAD) susceptibility alleles in the PAI-1 gene (2008) (0)
NEXT-GENERATION RNA SEQUENCING IN ALZHEIMER'S DISEASE AND PROGRESSIVE SUPRANUCLEAR PALSY (2014) (0)
GENE EXPRESSION PROFILING AND DNA METHYLATION IN ALZHEIMER'S DISEASE BRAINS (2014) (0)
P3-258: Further evidence of genetic association between SORL1 and Alzheimer's disease (2008) (0)
Association of Aβ42, Aβ40 and Aβ2/Aβ40 with cognitive impairment not demented (CIND) and dementia in persons of mexican ancestry (SALSA study): Different for diabetics versus non-diabetics? (2010) (0)
PS1 , PS2 , and APP mutations that cause Alzheimer’s disease increase Aβ42 (2006) (0)
TRANSCRIPTIONAL REGULATION OF GENES AT THE ALZHEIMER'S DISEASE RISK LOCI (2014) (0)
Abstract 10075: Mechanisms of Endothelial Dysfunction in Amyloid-{beta} Precursor Protein Transgenic Mice (2011) (0)
P3-216: Identification of CIS variants associating with expression levels of 12 late-onset Alzheimer's disease (LOAD) candidate genes in a Genome-Wide Association Study (GWAS) (2008) (0)
IN SITU HYBRIDIZATION IN HUMAN NUCLEUS BASALIS OF MEYNERT: 99 (1987) (0)
CONVERGENT ANALYSIS OF ENDOPHENOTYPES IN PROGRESSIVE SUPRANUCLEAR PALSY (2016) (0)
ARE PLASMA Aβ MEASURES ASSOCIATED WITH LONGITUDINAL CHANGE IN HIPPOCAMPAL VOLUME? (2014) (0)
Investigating blood gene expression levels as a biomarker for LOAD. (P5.028) (2015) (0)
ASSESSMENT OF THE KNOWN AND CANDIDATE ALZHEIMER'S DISEASE GENES IN AFRICAN-AMERICANS (2016) (0)
FROM SYSTEMS LEVEL TRANSCRIPTOMICS TO NEW IMMUNE TARGETS FOR ALZHEIMER’S DISEASE (2016) (0)
Effect of APOE4 status and Alzheimer's disease on posterior cingulate connectivity (2010) (0)
Exploring alternative splicing and gene expression of load candidate genes in blood (2015) (0)
P1-370: Reduction of interference in sandwich ELISAs measuring the amyloid β protein in human plasma (2008) (0)
LINKAGE AND WHOLE GENOME SEQUENCE ANALYSIS OF ALZHEIMER'S DISEASE RESILIENCE AND RISK (2016) (0)
P1-360 Analysis of variants in UBQLN1 for association with late onset Alzheimer’s disease (LOAD) (2006) (0)
Association study of late-onset Alzheimer's disease risk variants and memory decline (2013) (0)
Plasma β‐Amyloid as a Surrogate Genetic Marker in Late‐Onset Alzheimer's Disease (2002) (0)
O1-04-06 Identification of loci determining susceptibility to the lethal effects of APP transgene overexpression (2004) (0)
Correction to: Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer’s disease resilience (2018) (0)
P3-276: BRI2 (ITM2B) shows genetic association with late-onset Alzheimer's disease (2008) (0)
P3-208: Genetic variation in PCDH11X associates with Alzheimer's disease in a two-stage GWAS study (2008) (0)
Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study (2020) (0)
P4-368 NSAIDS improve amyloid beta protein-induced deficits in memory and synaptic plasticity (2004) (0)
Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications (2012) (0)
Brain Expression Genome-Wide Association Study (eGWAS) Identifies Human Disease-Associated Variants (P05.069) (2012) (0)
AMYLOID PROTEIN PRECURSOR mRNA LACKING THE KUNITZ PROTEASE INHIBITOR SEQUENCE INCREASES IN AD NUCLEUS BASALIS AND LOCUS CERULEUS NEURONS (1988) (0)
of variant-level batch effects on identification large sequencing studies (2020) (0)
Correlative MemoryDeficits, AP3 Elevation, and Amyloid Plaques inTransgenic Mice (1996) (0)
23 Analysis of soluble, extracellular amyloid ß protein concentration in Alzheimer's disease (1996) (0)
Exploiting blood transcriptome for gene and pathway identification in Alzheimer's disease (2015) (0)
Identification of human disease-associated variants in a brain expression genome-wide association study (eGWAS) (2012) (0)
THE ROLE OF AMYLOID β PEPTIDE TERMINATING AT AMINO ACID 42 IN EARLY ONSET ALZHEIMER’S DISEASE (1998) (0)
Abstract 25: Peroxisome Proliferator Activated Receptor - δ Agonist GW501516 Restores Bioavailability Of Tetrahydrobiopterin And Prevents Cerebral Vascular Dysfunction In Tg2576 Mice Overexpressing Amyloid Precursor Protein (2012) (0)
INTEGRATIVE SYSTEMS BIOLOGY APPROACH TO IDENTIFY NOVEL RISK FACTORS FOR PSP (2017) (0)
Association of ACE SNPs including covariates age , gender and APOE (2016) (0)
Infusion of Intravenous Immunoglobulin (IVIg) Containing anti-Abeta Antibodies is Associated with a Decrease of Abeta in Cerebrospinal Fluid (CSF) and Increase of Abeta in Blood from 8 Patients with Mild Alzheimer's Disease (AD) (2008) (0)
PROTEASES IN ALZHEIMERʼS DISEASE AND CONTROL CEREBROSPINAL FLUID: 13 (1990) (0)
Differential association of memory endophenotypes to APOE alleles (2011) (0)
Correction to: Apolipoprotein E regulates lipid metabolism and α‑synuclein pathology in human iPSC‑derived cerebral organoids (2021) (0)
Expression QTL Studies in LOAD and PSP Brains by Next-Generation RNA Sequencing (P2.147) (2014) (0)
Neurox associations with Alzheimer's disease in african americans (2015) (0)
Genetic Variants Influencing Human Longevity from Late-Onset Alzheimer’s Disease (LOAD) Genome-Wide Association Studies (GWAS) (2011) (0)
Metabolism and Function of Presenilin 1 (1998) (0)
atrophy and posterior AD Late-onset Alzheimer disease genetic variants in posterior cortical (0)
Natural history of amyloid-beta peptides in the CNS and periphery (2005) (0)
Acetylcholinesterase promotes beta-amyloid plaque formation in vivo (2001) (0)
813 Quantitative analysis of amyloid B protein with amino-terminal pyroglutamate 3 in alzheimer's disease brains (1997) (0)
Investigating cis-SNP/mRNA level associations of candidate Alzheimer genes in different brain regions of patients and controls (2010) (0)
CHARACTERIZATION OF SOLUBLE TRUNCATED FORMS OF THE AMYLOID PRECURSOR PROTEIN FROM HUMAN PLASMA: 148 (1990) (0)
High plasma Aβ40 levels are associated with incident Cognitive Impairment not Demented (CIND) and dementia cases in persons of Mexican ancestry (SALSA study) (2009) (0)
Genetic association of progressive supranuclear palsy (PSP) risk loci variants with brain gene expression and neuropathology endophenotypes (2012) (0)
1027-189 Chronic endothelin receptor antagonism preserves endothelial function in a transgenic mouse model of alzheimer's disease (2004) (0)
O2-07-04 COPY NUMBER POLYMORPHISM AT CHROMOSOME 19 LOCUS ASSOCIATED WITH LATE-ONSET ALZHEIMER’S DISEASE (2010) (0)
Plasma AB levels as a premorbid biomarker for cognitive decline, mild cognitive impairment (MCI) and Alzheimer disease (AD) (2005) (0)
Association of plasma beta-amyloid levels and risk of dementia, Alzheimer's disease, brain structure and cognitive functions in the Framingham Heart Study (2013) (0)
216. The effect of amyloid precursor protein and presenilin mutations on amyloid beta protein (1996) (0)
Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease (2018) (0)
New Therapies for Alzheimer's Disease (2001) (0)
The β amyloid protein precursor: Analysis of mRNAs in ad and control brains and of soluble derivatives in human cerebrospinal fluid (1990) (0)
IC-P-087 Annualized decrease in plasma Aβ42 correlates with annualized decrease in hippocampal volume (2006) (0)
TRANSCRIPTIONAL REGULATION AT THE TREM GENE CLUSTER IN AD BRAINS (2014) (0)
Gene‐based polygenic score analysis identifies novel immune genes with deleterious variants that associate with Alzheimer’s disease (2022) (0)
AWARDS (2006) (0)
Transcript Profiling Analysis Of Alzheimer’s Disease Brains. (I5-1.003) (2014) (0)
The X-chromosome and Alzheimer's disease (2010) (0)
P2-012 Dietary fatty acid source: effects on Aβ, copper and iron metabolism (2004) (0)
Network-driven plasma proteomics expose molecular changes in the Alzheimer’s brain (2016) (0)
Cognitive Performance Correlates with Resting State Connectivity and is Effected by APOE Status (2010) (0)
Genome-Wide Association Study of Brain Gene Expression Levels (eGWAS) (2011) (0)
Differential Epistatic Interactions with Alternative APOE Alleles in Late-Onset Alzheimer’s Disease (2011) (0)
S2-01-05 Genetics 5 (2004) (0)
＜Symposium IV＞Genetic variation in PCDH11X is associated with susceptibility to late onset Alzheimer's disease (2010) (0)
630 Accumulation of ß amyloid in transgenic mice (1996) (0)
Characterization of brain region- and disease-specific IDE expression in Alzheimer patients and controls (2010) (0)
Evaluation of Cognitive Endophenotypes for Association with CLU, CR1 and PICALM LOAD Risk Genes (2011) (0)
f8-amyloid protein precursor of Alzheimer disease has soluble derivatives found in human brain and cerebrospinal fluid (0)
MULTIPLE ABCA7 MISSENSE VARIANTS MINED FROM THE EXOME VARIANT SERVER SHOW INDEPENDENT ASSOCIATION WITH INCREASED OR DECREASED RISK OF LATE-ONSET ALZHEIMER'S DISEASE (LOAD) (2014) (0)
Accumulation of amyloid β protein in the detergent-insoluble membrane compartment (2000) (0)
Evaluation of known Alzheimer's genes for SNPs that influence their brain expression (eSNPs) (2011) (0)
Thef8-amyloid protein precursor ofAlzheimer disease hassoluble derivatives foundinhumanbrain andcerebrospinal fluid (1989) (0)
Investigation of established Alzheimer's disease–risk SNPs for association with Alzheimer's disease in an African-American case control series (2012) (0)
Genome-wide association study of Alzheimer's with psychotic symptoms (2009) (0)
Regulation of endogenous amyloid β-protein production by APOE in a human cortical culture model (2000) (0)
Accumulation of of (3-Amyloid Fibrils in Pancreas Transgenic Mice (1996) (0)
＜Luncheon Seminar＞Current concepts in Alzheimer's disease (2010) (0)
Genome-Wide Association Study (GWAS) of plasma Aß levels in the dalmatian islands of Vis and korcula (2009) (0)
P4-095 Analysis of Alzheimer's disease candidate genes on chromosome 10 (2004) (0)
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (2019) (0)
Aβ42 deposition is selectively altered in brains of Aβ1–42 immunized TG2576 mice (2000) (0)
INCREASED ASYMMETRIC ACETYLCHOLINESTERASE IN ALZHEIMER'S DISEASE IS LOCALIZED IN NEURITIC PLAQUES: 17 (1987) (0)
Conserved architecture of brain transcriptome changes between Alzheimer's disease and progressive supranuclear palsy in pathologically affected and unaffected regions (2021) (0)
Author Correction: APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids (2021) (0)
Investigation Of Transcriptional Regulation At The Alzheimer’s Disease Risk Loci. (S28.006) (2014) (0)
Genetic and epigenetic influences on brain gene expression in psp (2015) (0)
P4-167: Investigation of mitochondrial DNA damage in late-onset Alzheimer's disease (2008) (0)
Cognitive Performance Correlates with Resting State Connectivity and is Effected by APOE Status (2010) (0)
A multi-centre study of ACE and the risk of late-onset Alzheimer ’ s disease (2013) (0)
Relationship of plasma amyloid beta fragments to serum cholesterol HDL, albumin, body mass index and apoe genotype (2000) (0)
Novel Progressive Supranuclear Palsy (PSP) Risk Loci Variants Associate with Brain Gene Expression Levels (S54.002) (2012) (0)
NOVEL CANDIDATE AD-RISK LOCI IDENTIFIED THROUGH WHOLE EXOME SEQUENCING IN AFRICAN-AMERICANS (2017) (0)
PROTEINS IN THE −38–48 kDA SIZE RANGE ARE SPECIFICALLY LABELED BY AN ANTISERUM TO BAPP695 THAT DETECTS KNOWN MEMBRANE-ASSOCIATED AND SOLUBLE FORMS OF THE B AMYLOID PROTEIN PRECURSOR: 12 (1990) (0)
USING TISSUE-BASED TRANSCRIPTOMICS TO PROFILE CELL TYPE VARIABILITY IN THE BRAIN (2017) (0)
CHOLINERGIC PROTEINS IN ALZHEIMERʼS DISEASE (1985) (0)
P3-102 Annualized decrease in plasma Aβ42 correlates with annualized decrease in hippocampal volume (2006) (0)

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